longtext: 1ZOI-pdb

content
HEADER    HYDROLASE                               13-MAY-05   1ZOI
TITLE     CRYSTAL STRUCTURE OF A STEREOSELECTIVE ESTERASE FROM
TITLE    2 PSEUDOMONAS PUTIDA IFO12996
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: ESTERASE;
COMPND   3 CHAIN: A, B, C;
COMPND   4 EC: 3.1.-.-;
COMPND   5 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: PSEUDOMONAS PUTIDA;
SOURCE   3 ORGANISM_COMMON: BATERIA;
SOURCE   4 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   5 EXPRESSION_SYSTEM_COMMON: BACTERIA
KEYWDS    ESTERASE, PSEUDOMONAS PUTIDA, ALPHA/BETA HYDROLASE FOLD
EXPDTA    X-RAY DIFFRACTION
AUTHOR    F.ELMI,H.T.LEE,J.Y.HUANG,Y.C.HSIEH,Y.L.WANG,Y.J.CHEN,
AUTHOR   2 S.Y.SHAW,C.J.CHEN
REVDAT   1   02-MAY-06 1ZOI    0
JRNL        AUTH   F.ELMI,H.T.LEE,J.Y.HUANG,Y.C.HSIEH,Y.L.WANG,
JRNL        AUTH 2 Y.J.CHEN,S.Y.SHAW,C.J.CHEN
JRNL        TITL   STEREOSELECTIVE ESTERASE FROM PSEUDOMONAS PUTIDA
JRNL        TITL 2 IFO12996 REVEALS ALPHA/BETA HYDROLASE FOLDS FOR
JRNL        TITL 3 D-BETA-ACETYLTHIOISOBUTYRIC ACID SYNTHESIS
JRNL        REF    J.BACTERIOL.                  V. 187  8470 2005
JRNL        REFN   ASTM JOBAAY  US ISSN 0021-9193
REMARK   1
REMARK   2
REMARK   2 RESOLUTION. 1.60 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : CNS 1.1
REMARK   3   AUTHORS     : BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE-
REMARK   3               : KUNSTLEVE,JIANG,KUSZEWSKI,NILGES, PANNU,
REMARK   3               : READ,RICE,SIMONSON,WARREN
REMARK   3
REMARK   3  REFINEMENT TARGET : ENGH & HUBER
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.60
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 25.00
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 2.000
REMARK   3   DATA CUTOFF HIGH         (ABS(F)) : NULL
REMARK   3   DATA CUTOFF LOW          (ABS(F)) : NULL
REMARK   3   COMPLETENESS (WORKING+TEST)   (%) : NULL
REMARK   3   NUMBER OF REFLECTIONS             : 93768
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : NULL
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE            (WORKING SET) : 0.220
REMARK   3   FREE R VALUE                     : 0.239
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : NULL
REMARK   3   FREE R VALUE TEST SET COUNT      : 9413
REMARK   3   ESTIMATED ERROR OF FREE R VALUE  : NULL
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : NULL
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : NULL
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : NULL
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : NULL
REMARK   3   REFLECTIONS IN BIN    (WORKING SET) : NULL
REMARK   3   BIN R VALUE           (WORKING SET) : NULL
REMARK   3   BIN FREE R VALUE                    : NULL
REMARK   3   BIN FREE R VALUE TEST SET SIZE  (%) : NULL
REMARK   3   BIN FREE R VALUE TEST SET COUNT     : NULL
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE : NULL
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 6377
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 0
REMARK   3   SOLVENT ATOMS            : 317
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  ESTIMATED COORDINATE ERROR.
REMARK   3   ESD FROM LUZZATI PLOT        (A) : 0.21
REMARK   3   ESD FROM SIGMAA              (A) : 0.07
REMARK   3   LOW RESOLUTION CUTOFF        (A) : 5.00
REMARK   3
REMARK   3  CROSS-VALIDATED ESTIMATED COORDINATE ERROR.
REMARK   3   ESD FROM C-V LUZZATI PLOT    (A) : 0.23
REMARK   3   ESD FROM C-V SIGMAA          (A) : 0.11
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES.
REMARK   3   BOND LENGTHS                 (A) : 0.005
REMARK   3   BOND ANGLES            (DEGREES) : 1.30
REMARK   3   DIHEDRAL ANGLES        (DEGREES) : NULL
REMARK   3   IMPROPER ANGLES        (DEGREES) : NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL MODEL : NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.    RMS    SIGMA
REMARK   3   MAIN-CHAIN BOND              (A**2) : NULL  ; NULL
REMARK   3   MAIN-CHAIN ANGLE             (A**2) : NULL  ; NULL
REMARK   3   SIDE-CHAIN BOND              (A**2) : NULL  ; NULL
REMARK   3   SIDE-CHAIN ANGLE             (A**2) : NULL  ; NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELING.
REMARK   3   METHOD USED : NULL
REMARK   3   KSOL        : NULL
REMARK   3   BSOL        : NULL
REMARK   3
REMARK   3  NCS MODEL : NULL
REMARK   3
REMARK   3  NCS RESTRAINTS.                         RMS   SIGMA/WEIGHT
REMARK   3   GROUP  1  POSITIONAL            (A) : NULL  ; NULL
REMARK   3   GROUP  1  B-FACTOR           (A**2) : NULL  ; NULL
REMARK   3
REMARK   3  PARAMETER FILE  1  : NULL
REMARK   3  TOPOLOGY FILE  1   : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 1ZOI COMPLIES WITH FORMAT V. 2.3, 09-JULY-1998
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 19-MAY-2005.
REMARK 100 THE RCSB ID CODE IS RCSB032958.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 27-OCT-2004
REMARK 200  TEMPERATURE           (KELVIN) : 100.0
REMARK 200  PH                             : 4.00
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SPRING-8
REMARK 200  BEAMLINE                       : BL12B2
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1
REMARK 200  MONOCHROMATOR                  : SI 111 CHANNEL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 4
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000
REMARK 200  DATA SCALING SOFTWARE          : SCALA
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 93768
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.600
REMARK 200  RESOLUTION RANGE LOW       (A) : 25.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 2.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 92.3
REMARK 200  DATA REDUNDANCY                : 6.300
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : NULL
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.60
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.66
REMARK 200  COMPLETENESS FOR SHELL     (%) : 82.3
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: CNS
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 40.09
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.09
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: AMMONIUM SULPHATE, CITRIC ACID, PH
REMARK 280  4.0, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 291K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   1/2-X,-Y,1/2+Z
REMARK 290       3555   -X,1/2+Y,1/2-Z
REMARK 290       4555   1/2+X,1/2-Y,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       25.27800
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       76.81500
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       49.05400
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       76.81500
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       25.27800
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       49.05400
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT
REMARK 300 WHICH CONSISTS OF 3 CHAIN(S). SEE REMARK 350 FOR
REMARK 300 INFORMATION ON GENERATING THE BIOLOGICAL MOLECULE(S).
REMARK 350
REMARK 350 GENERATING THE BIOMOLECULE
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A     1
REMARK 465     MET B     1
REMARK 465     SER B   276
REMARK 465     MET C     1
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),F6.3)
REMARK 500
REMARK 500 EXPECTED VALUES: ENGH AND HUBER, 1991
REMARK 500
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION
REMARK 500    PRO A  32   CG    PRO A  32   CD     0.038
REMARK 500    MET A  72   SD    MET A  72   CE    -0.059
REMARK 500    MET A 189   CG    MET A 189   SD     0.040
REMARK 500    MET A 222   SD    MET A 222   CE    -0.042
REMARK 500    PRO B  32   CB    PRO B  32   CG     0.050
REMARK 500    PRO B  32   CG    PRO B  32   CD     0.046
REMARK 500    PRO C  32   CG    PRO C  32   CD     0.032
REMARK 500    MET C 107   CG    MET C 107   SD    -0.033
REMARK 500    MET C 189   CG    MET C 189   SD     0.037
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES: ENGH AND HUBER, 1991
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    GLY A   9   N   -  CA  -  C   ANGL. DEV. =  7.8 DEGREES
REMARK 500    VAL A  24   N   -  CA  -  C   ANGL. DEV. =  8.6 DEGREES
REMARK 500    PRO A  32   C   -  N   -  CA  ANGL. DEV. =  9.6 DEGREES
REMARK 500    LEU A  33   N   -  CA  -  C   ANGL. DEV. =  8.0 DEGREES
REMARK 500    ARG A  51   N   -  CA  -  C   ANGL. DEV. =-12.0 DEGREES
REMARK 500    VAL A  92   N   -  CA  -  C   ANGL. DEV. = -7.9 DEGREES
REMARK 500    PRO A 165   N   -  CA  -  C   ANGL. DEV. =  9.6 DEGREES
REMARK 500    GLY B   9   N   -  CA  -  C   ANGL. DEV. =  8.3 DEGREES
REMARK 500    ILE B  25   N   -  CA  -  C   ANGL. DEV. = -7.9 DEGREES
REMARK 500    PRO B  32   C   -  N   -  CA  ANGL. DEV. =  9.1 DEGREES
REMARK 500    LEU B  33   N   -  CA  -  C   ANGL. DEV. =  7.6 DEGREES
REMARK 500    GLY B  49   N   -  CA  -  C   ANGL. DEV. =  9.9 DEGREES
REMARK 500    ARG B  51   N   -  CA  -  C   ANGL. DEV. =-13.7 DEGREES
REMARK 500    VAL B  92   N   -  CA  -  C   ANGL. DEV. = -8.6 DEGREES
REMARK 500    VAL B 124   N   -  CA  -  C   ANGL. DEV. =  7.7 DEGREES
REMARK 500    SER B 152   N   -  CA  -  C   ANGL. DEV. =  9.0 DEGREES
REMARK 500    ARG B 159   N   -  CA  -  C   ANGL. DEV. = -7.7 DEGREES
REMARK 500    PRO B 165   N   -  CA  -  C   ANGL. DEV. =  9.8 DEGREES
REMARK 500    GLY C   9   N   -  CA  -  C   ANGL. DEV. =  9.3 DEGREES
REMARK 500    VAL C  24   N   -  CA  -  C   ANGL. DEV. =  8.3 DEGREES
REMARK 500    ILE C  25   N   -  CA  -  C   ANGL. DEV. = -7.7 DEGREES
REMARK 500    PRO C  32   C   -  N   -  CA  ANGL. DEV. =  9.5 DEGREES
REMARK 500    LEU C  33   N   -  CA  -  C   ANGL. DEV. =  7.7 DEGREES
REMARK 500    GLY C  49   N   -  CA  -  C   ANGL. DEV. =  9.9 DEGREES
REMARK 500    ARG C  51   N   -  CA  -  C   ANGL. DEV. =-13.0 DEGREES
REMARK 500    SER C 152   N   -  CA  -  C   ANGL. DEV. =  7.8 DEGREES
REMARK 500    PRO C 165   N   -  CA  -  C   ANGL. DEV. =  9.2 DEGREES
REMARK 500    PRO C 259   C   -  N   -  CA  ANGL. DEV. = -7.7 DEGREES
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    SER A  97     -118.81     50.24
REMARK 500    SER B  97     -118.90     51.65
DBREF  1ZOI A    1   276  GB     1110542  AAB35246         1    276
DBREF  1ZOI B    1   276  GB     1110542  AAB35246         1    276
DBREF  1ZOI C    1   276  GB     1110542  AAB35246         1    276
SEQADV 1ZOI LEU A   42  GB   1110542   MET    42 CONFLICT
SEQADV 1ZOI GLU A  112  GB   1110542   ALA   112 CONFLICT
SEQADV 1ZOI GLY A  133  GB   1110542   ASP   133 CONFLICT
SEQADV 1ZOI GLU A  175  GB   1110542   ASP   175 CONFLICT
SEQADV 1ZOI GLN A  216  GB   1110542   THR   216 CONFLICT
SEQADV 1ZOI VAL A  237  GB   1110542   LEU   237 CONFLICT
SEQADV 1ZOI ALA A  247  GB   1110542   THR   247 CONFLICT
SEQADV 1ZOI LYS A  252  GB   1110542   GLN   252 CONFLICT
SEQADV 1ZOI LEU B   42  GB   1110542   MET    42 CONFLICT
SEQADV 1ZOI GLU B  112  GB   1110542   ALA   112 CONFLICT
SEQADV 1ZOI GLY B  133  GB   1110542   ASP   133 CONFLICT
SEQADV 1ZOI GLU B  175  GB   1110542   ASP   175 CONFLICT
SEQADV 1ZOI GLN B  216  GB   1110542   THR   216 CONFLICT
SEQADV 1ZOI VAL B  237  GB   1110542   LEU   237 CONFLICT
SEQADV 1ZOI ALA B  247  GB   1110542   THR   247 CONFLICT
SEQADV 1ZOI LYS B  252  GB   1110542   GLN   252 CONFLICT
SEQADV 1ZOI LEU C   42  GB   1110542   MET    42 CONFLICT
SEQADV 1ZOI GLU C  112  GB   1110542   ALA   112 CONFLICT
SEQADV 1ZOI GLY C  133  GB   1110542   ASP   133 CONFLICT
SEQADV 1ZOI GLU C  175  GB   1110542   ASP   175 CONFLICT
SEQADV 1ZOI GLN C  216  GB   1110542   THR   216 CONFLICT
SEQADV 1ZOI VAL C  237  GB   1110542   LEU   237 CONFLICT
SEQADV 1ZOI ALA C  247  GB   1110542   THR   247 CONFLICT
SEQADV 1ZOI LYS C  252  GB   1110542   GLN   252 CONFLICT
SEQRES   1 A  276  MET SER TYR VAL THR THR LYS ASP GLY VAL GLN ILE PHE
SEQRES   2 A  276  TYR LYS ASP TRP GLY PRO ARG ASP ALA PRO VAL ILE HIS
SEQRES   3 A  276  PHE HIS HIS GLY TRP PRO LEU SER ALA ASP ASP TRP ASP
SEQRES   4 A  276  ALA GLN LEU LEU PHE PHE LEU ALA HIS GLY TYR ARG VAL
SEQRES   5 A  276  VAL ALA HIS ASP ARG ARG GLY HIS GLY ARG SER SER GLN
SEQRES   6 A  276  VAL TRP ASP GLY HIS ASP MET ASP HIS TYR ALA ASP ASP
SEQRES   7 A  276  VAL ALA ALA VAL VAL ALA HIS LEU GLY ILE GLN GLY ALA
SEQRES   8 A  276  VAL HIS VAL GLY HIS SER THR GLY GLY GLY GLU VAL VAL
SEQRES   9 A  276  ARG TYR MET ALA ARG HIS PRO GLU ASP LYS VAL ALA LYS
SEQRES  10 A  276  ALA VAL LEU ILE ALA ALA VAL PRO PRO LEU MET VAL GLN
SEQRES  11 A  276  THR PRO GLY ASN PRO GLY GLY LEU PRO LYS SER VAL PHE
SEQRES  12 A  276  ASP GLY PHE GLN ALA GLN VAL ALA SER ASN ARG ALA GLN
SEQRES  13 A  276  PHE TYR ARG ASP VAL PRO ALA GLY PRO PHE TYR GLY TYR
SEQRES  14 A  276  ASN ARG PRO GLY VAL GLU ALA SER GLU GLY ILE ILE GLY
SEQRES  15 A  276  ASN TRP TRP ARG GLN GLY MET ILE GLY SER ALA LYS ALA
SEQRES  16 A  276  HIS TYR ASP GLY ILE VAL ALA PHE SER GLN THR ASP PHE
SEQRES  17 A  276  THR GLU ASP LEU LYS GLY ILE GLN GLN PRO VAL LEU VAL
SEQRES  18 A  276  MET HIS GLY ASP ASP ASP GLN ILE VAL PRO TYR GLU ASN
SEQRES  19 A  276  SER GLY VAL LEU SER ALA LYS LEU LEU PRO ASN GLY ALA
SEQRES  20 A  276  LEU LYS THR TYR LYS GLY TYR PRO HIS GLY MET PRO THR
SEQRES  21 A  276  THR HIS ALA ASP VAL ILE ASN ALA ASP LEU LEU ALA PHE
SEQRES  22 A  276  ILE ARG SER
SEQRES   1 B  276  MET SER TYR VAL THR THR LYS ASP GLY VAL GLN ILE PHE
SEQRES   2 B  276  TYR LYS ASP TRP GLY PRO ARG ASP ALA PRO VAL ILE HIS
SEQRES   3 B  276  PHE HIS HIS GLY TRP PRO LEU SER ALA ASP ASP TRP ASP
SEQRES   4 B  276  ALA GLN LEU LEU PHE PHE LEU ALA HIS GLY TYR ARG VAL
SEQRES   5 B  276  VAL ALA HIS ASP ARG ARG GLY HIS GLY ARG SER SER GLN
SEQRES   6 B  276  VAL TRP ASP GLY HIS ASP MET ASP HIS TYR ALA ASP ASP
SEQRES   7 B  276  VAL ALA ALA VAL VAL ALA HIS LEU GLY ILE GLN GLY ALA
SEQRES   8 B  276  VAL HIS VAL GLY HIS SER THR GLY GLY GLY GLU VAL VAL
SEQRES   9 B  276  ARG TYR MET ALA ARG HIS PRO GLU ASP LYS VAL ALA LYS
SEQRES  10 B  276  ALA VAL LEU ILE ALA ALA VAL PRO PRO LEU MET VAL GLN
SEQRES  11 B  276  THR PRO GLY ASN PRO GLY GLY LEU PRO LYS SER VAL PHE
SEQRES  12 B  276  ASP GLY PHE GLN ALA GLN VAL ALA SER ASN ARG ALA GLN
SEQRES  13 B  276  PHE TYR ARG ASP VAL PRO ALA GLY PRO PHE TYR GLY TYR
SEQRES  14 B  276  ASN ARG PRO GLY VAL GLU ALA SER GLU GLY ILE ILE GLY
SEQRES  15 B  276  ASN TRP TRP ARG GLN GLY MET ILE GLY SER ALA LYS ALA
SEQRES  16 B  276  HIS TYR ASP GLY ILE VAL ALA PHE SER GLN THR ASP PHE
SEQRES  17 B  276  THR GLU ASP LEU LYS GLY ILE GLN GLN PRO VAL LEU VAL
SEQRES  18 B  276  MET HIS GLY ASP ASP ASP GLN ILE VAL PRO TYR GLU ASN
SEQRES  19 B  276  SER GLY VAL LEU SER ALA LYS LEU LEU PRO ASN GLY ALA
SEQRES  20 B  276  LEU LYS THR TYR LYS GLY TYR PRO HIS GLY MET PRO THR
SEQRES  21 B  276  THR HIS ALA ASP VAL ILE ASN ALA ASP LEU LEU ALA PHE
SEQRES  22 B  276  ILE ARG SER
SEQRES   1 C  276  MET SER TYR VAL THR THR LYS ASP GLY VAL GLN ILE PHE
SEQRES   2 C  276  TYR LYS ASP TRP GLY PRO ARG ASP ALA PRO VAL ILE HIS
SEQRES   3 C  276  PHE HIS HIS GLY TRP PRO LEU SER ALA ASP ASP TRP ASP
SEQRES   4 C  276  ALA GLN LEU LEU PHE PHE LEU ALA HIS GLY TYR ARG VAL
SEQRES   5 C  276  VAL ALA HIS ASP ARG ARG GLY HIS GLY ARG SER SER GLN
SEQRES   6 C  276  VAL TRP ASP GLY HIS ASP MET ASP HIS TYR ALA ASP ASP
SEQRES   7 C  276  VAL ALA ALA VAL VAL ALA HIS LEU GLY ILE GLN GLY ALA
SEQRES   8 C  276  VAL HIS VAL GLY HIS SER THR GLY GLY GLY GLU VAL VAL
SEQRES   9 C  276  ARG TYR MET ALA ARG HIS PRO GLU ASP LYS VAL ALA LYS
SEQRES  10 C  276  ALA VAL LEU ILE ALA ALA VAL PRO PRO LEU MET VAL GLN
SEQRES  11 C  276  THR PRO GLY ASN PRO GLY GLY LEU PRO LYS SER VAL PHE
SEQRES  12 C  276  ASP GLY PHE GLN ALA GLN VAL ALA SER ASN ARG ALA GLN
SEQRES  13 C  276  PHE TYR ARG ASP VAL PRO ALA GLY PRO PHE TYR GLY TYR
SEQRES  14 C  276  ASN ARG PRO GLY VAL GLU ALA SER GLU GLY ILE ILE GLY
SEQRES  15 C  276  ASN TRP TRP ARG GLN GLY MET ILE GLY SER ALA LYS ALA
SEQRES  16 C  276  HIS TYR ASP GLY ILE VAL ALA PHE SER GLN THR ASP PHE
SEQRES  17 C  276  THR GLU ASP LEU LYS GLY ILE GLN GLN PRO VAL LEU VAL
SEQRES  18 C  276  MET HIS GLY ASP ASP ASP GLN ILE VAL PRO TYR GLU ASN
SEQRES  19 C  276  SER GLY VAL LEU SER ALA LYS LEU LEU PRO ASN GLY ALA
SEQRES  20 C  276  LEU LYS THR TYR LYS GLY TYR PRO HIS GLY MET PRO THR
SEQRES  21 C  276  THR HIS ALA ASP VAL ILE ASN ALA ASP LEU LEU ALA PHE
SEQRES  22 C  276  ILE ARG SER
FORMUL   4  HOH   *317(H2 O1)
HELIX    1   1 SER A   34  ASP A   37  5                                   4
HELIX    2   2 TRP A   38  HIS A   48  1                                  11
HELIX    3   3 ASP A   71  GLY A   87  1                                  17
HELIX    4   4 THR A   98  HIS A  110  1                                  13
HELIX    5   5 PRO A  139  ASN A  153  1                                  15
HELIX    6   6 ASN A  153  GLY A  164  1                                  12
HELIX    7   7 SER A  177  GLY A  191  1                                  15
HELIX    8   8 SER A  192  GLN A  205  1                                  14
HELIX    9   9 PHE A  208  ILE A  215  1                                   8
HELIX   10  10 SER A  235  LEU A  243  1                                   9
HELIX   11  11 GLY A  257  HIS A  262  1                                   6
HELIX   12  12 HIS A  262  ARG A  275  1                                  14
HELIX   13  13 SER B   34  ASP B   37  5                                   4
HELIX   14  14 TRP B   38  ALA B   47  1                                  10
HELIX   15  15 ASP B   71  GLY B   87  1                                  17
HELIX   16  16 THR B   98  HIS B  110  1                                  13
HELIX   17  17 PRO B  139  ASN B  153  1                                  15
HELIX   18  18 ASN B  153  GLY B  164  1                                  12
HELIX   19  19 SER B  177  GLY B  191  1                                  15
HELIX   20  20 SER B  192  GLN B  205  1                                  14
HELIX   21  21 PHE B  208  ILE B  215  1                                   8
HELIX   22  22 SER B  235  LEU B  243  1                                   9
HELIX   23  23 GLY B  257  HIS B  262  1                                   6
HELIX   24  24 HIS B  262  ARG B  275  1                                  14
HELIX   25  25 SER C   34  ASP C   37  5                                   4
HELIX   26  26 TRP C   38  ALA C   47  1                                  10
HELIX   27  27 ASP C   71  GLY C   87  1                                  17
HELIX   28  28 THR C   98  HIS C  110  1                                  13
HELIX   29  29 PRO C  139  ASN C  153  1                                  15
HELIX   30  30 ASN C  153  GLY C  164  1                                  12
HELIX   31  31 SER C  177  ILE C  190  1                                  14
HELIX   32  32 SER C  192  GLN C  205  1                                  14
HELIX   33  33 PHE C  208  ILE C  215  1                                   8
HELIX   34  34 SER C  235  LEU C  243  1                                   9
HELIX   35  35 GLY C  257  HIS C  262  1                                   6
HELIX   36  36 HIS C  262  ARG C  275  1                                  14
SHEET    1   A 8 TYR A   3  THR A   5  0
SHEET    2   A 8 GLN A  11  TRP A  17 -1  O  ILE A  12   N  VAL A   4
SHEET    3   A 8 ARG A  51  HIS A  55 -1  O  VAL A  52   N  TRP A  17
SHEET    4   A 8 VAL A  24  HIS A  28  1  N  PHE A  27   O  VAL A  53
SHEET    5   A 8 VAL A  92  HIS A  96  1  O  VAL A  92   N  HIS A  26
SHEET    6   A 8 ALA A 118  ILE A 121  1  O  ILE A 121   N  GLY A  95
SHEET    7   A 8 VAL A 219  GLY A 224  1  O  LEU A 220   N  LEU A 120
SHEET    8   A 8 GLY A 246  TYR A 251  1  O  ALA A 247   N  VAL A 221
SHEET    1   B 8 TYR B   3  THR B   5  0
SHEET    2   B 8 GLN B  11  TRP B  17 -1  O  ILE B  12   N  VAL B   4
SHEET    3   B 8 ARG B  51  HIS B  55 -1  O  VAL B  52   N  TRP B  17
SHEET    4   B 8 VAL B  24  HIS B  28  1  N  PHE B  27   O  VAL B  53
SHEET    5   B 8 VAL B  92  HIS B  96  1  O  VAL B  92   N  HIS B  26
SHEET    6   B 8 ALA B 118  ILE B 121  1  O  ILE B 121   N  GLY B  95
SHEET    7   B 8 VAL B 219  GLY B 224  1  O  MET B 222   N  LEU B 120
SHEET    8   B 8 GLY B 246  TYR B 251  1  O  ALA B 247   N  VAL B 221
SHEET    1   C 8 TYR C   3  THR C   5  0
SHEET    2   C 8 GLN C  11  TRP C  17 -1  O  ILE C  12   N  VAL C   4
SHEET    3   C 8 ARG C  51  HIS C  55 -1  O  VAL C  52   N  TRP C  17
SHEET    4   C 8 VAL C  24  HIS C  28  1  N  PHE C  27   O  VAL C  53
SHEET    5   C 8 VAL C  92  HIS C  96  1  O  VAL C  92   N  HIS C  26
SHEET    6   C 8 ALA C 118  ILE C 121  1  O  ILE C 121   N  GLY C  95
SHEET    7   C 8 VAL C 219  GLY C 224  1  O  LEU C 220   N  LEU C 120
SHEET    8   C 8 GLY C 246  TYR C 251  1  O  ALA C 247   N  VAL C 221
CISPEP   1 TRP A   31    PRO A   32          0        -0.40
CISPEP   2 PRO A  125    PRO A  126          0         0.16
CISPEP   3 TRP B   31    PRO B   32          0        -0.49
CISPEP   4 PRO B  125    PRO B  126          0         0.27
CISPEP   5 TRP C   31    PRO C   32          0        -0.49
CISPEP   6 PRO C  125    PRO C  126          0         0.02
CRYST1   50.556   98.108  153.630  90.00  90.00  90.00 P 21 21 21   12
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.019780  0.000000  0.000000        0.00000
SCALE2      0.000000  0.010193  0.000000        0.00000
SCALE3      0.000000  0.000000  0.006509        0.00000
TER    2129      SER A 276
TER    4251      ARG B 275
TER    6380      SER C 276
MASTER      299    0    0   36   24    0    0    6 6694    3    0   66
END