| content |
HEADER VIRAL PROTEIN 07-JAN-26 22DX
TITLE CRYO-EM STRUCTURE OF MERS-COV S PROTEIN BOUND WITH RECEPTOR DPP4 IN
TITLE 2 THE CONFORMATION 1 (1 UP RBD AND 1 DPP4 BOUND).
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: DIPEPTIDYL PEPTIDASE 4 MEMBRANE FORM;
COMPND 3 CHAIN: A, B;
COMPND 4 SYNONYM: DIPEPTIDYL PEPTIDASE IV MEMBRANE FORM;
COMPND 5 ENGINEERED: YES;
COMPND 6 MOL_ID: 2;
COMPND 7 MOLECULE: SPIKE GLYCOPROTEIN;
COMPND 8 CHAIN: F, G, C;
COMPND 9 SYNONYM: S GLYCOPROTEIN,E2,PEPLOMER PROTEIN;
COMPND 10 ENGINEERED: YES
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 3 ORGANISM_COMMON: HUMAN;
SOURCE 4 ORGANISM_TAXID: 9606;
SOURCE 5 GENE: DPP4, ADCP2, CD26;
SOURCE 6 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE 7 EXPRESSION_SYSTEM_TAXID: 9606;
SOURCE 8 MOL_ID: 2;
SOURCE 9 ORGANISM_SCIENTIFIC: MIDDLE EAST RESPIRATORY SYNDROME-RELATED
SOURCE 10 CORONAVIRUS (ISOLATE UNITED KINGDOM/H123990006/2012);
SOURCE 11 ORGANISM_COMMON: MERS-COV, BETACORONAVIRUS ENGLAND 1;
SOURCE 12 ORGANISM_TAXID: 1263720;
SOURCE 13 GENE: S, 3;
SOURCE 14 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE 15 EXPRESSION_SYSTEM_TAXID: 9606
KEYWDS MERS-COV, SPIKE TRIMER, DPP4, VIRAL PROTEIN, VIRAL PROTEIN-RECEPTOR
KEYWDS 2 COMPLEX
EXPDTA ELECTRON MICROSCOPY
AUTHOR Y.J.WANG,L.SUN
REVDAT 1 02-SEP-26 22DX 0
JRNL AUTH Y.J.WANG,L.SUN
JRNL TITL CRYO-EM STRUCTURE OF MERS-COV S PROTEIN BOUND WITH RECEPTOR
JRNL TITL 2 DPP4 IN THE CONFORMATION 1 (1 UP RBD AND 1 DPP4 BOUND)
JRNL REF TO BE PUBLISHED
JRNL REFN
REMARK 2
REMARK 2 RESOLUTION. 3.29 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 SOFTWARE PACKAGES : CRYOSPARC, PHENIX, CRYOSPARC
REMARK 3 RECONSTRUCTION SCHEMA : NULL
REMARK 3
REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT
REMARK 3 PDB ENTRY : NULL
REMARK 3 REFINEMENT SPACE : NULL
REMARK 3 REFINEMENT PROTOCOL : NULL
REMARK 3 REFINEMENT TARGET : NULL
REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL
REMARK 3
REMARK 3 FITTING PROCEDURE : NULL
REMARK 3
REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS
REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.290
REMARK 3 NUMBER OF PARTICLES : 28966
REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE
REMARK 3 CORRECTION
REMARK 3
REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL
REMARK 3
REMARK 3 OTHER DETAILS: NULL
REMARK 4
REMARK 4 22DX COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBC ON 10-JAN-26.
REMARK 100 THE DEPOSITION ID IS D_1300066704.
REMARK 245
REMARK 245 EXPERIMENTAL DETAILS
REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE
REMARK 245 SPECIMEN TYPE : NULL
REMARK 245
REMARK 245 ELECTRON MICROSCOPE SAMPLE
REMARK 245 SAMPLE TYPE : PARTICLE
REMARK 245 PARTICLE TYPE : POINT
REMARK 245 NAME OF SAMPLE : CRYO-EM STRUCTURE OF MERS-COV S
REMARK 245 PROTEIN BOUND WITH RECEPTOR
REMARK 245 DPP4 IN THE CONFORMATION 1 (1
REMARK 245 UP RBD AND 1 DPP4 BOUND).
REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL
REMARK 245 SAMPLE SUPPORT DETAILS : NULL
REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL
REMARK 245 SAMPLE BUFFER : NULL
REMARK 245 PH : 8.00
REMARK 245 SAMPLE DETAILS : NULL
REMARK 245
REMARK 245 DATA ACQUISITION
REMARK 245 DATE OF EXPERIMENT : NULL
REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL
REMARK 245 TEMPERATURE (KELVIN) : NULL
REMARK 245 MICROSCOPE MODEL : TFS KRIOS
REMARK 245 DETECTOR TYPE : FEI FALCON IV (4K X 4K)
REMARK 245 MINIMUM DEFOCUS (NM) : 1200.00
REMARK 245 MAXIMUM DEFOCUS (NM) : 2200.00
REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 NOMINAL CS : NULL
REMARK 245 IMAGING MODE : BRIGHT FIELD
REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5000.00
REMARK 245 ILLUMINATION MODE : FLOOD BEAM
REMARK 245 NOMINAL MAGNIFICATION : NULL
REMARK 245 CALIBRATED MAGNIFICATION : NULL
REMARK 245 SOURCE : FIELD EMISSION GUN
REMARK 245 ACCELERATION VOLTAGE (KV) : 300
REMARK 245 IMAGING DETAILS : NULL
REMARK 247
REMARK 247 ELECTRON MICROSCOPY
REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON
REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE
REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES
REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION
REMARK 247 OF THE STRUCTURE FACTORS.
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: PENTAMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: PENTAMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, F, G, C
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 MET A -14
REMARK 465 LEU A -13
REMARK 465 LEU A -12
REMARK 465 VAL A -11
REMARK 465 ASN A -10
REMARK 465 GLN A -9
REMARK 465 SER A -8
REMARK 465 HIS A -7
REMARK 465 GLN A -6
REMARK 465 GLY A -5
REMARK 465 PHE A -4
REMARK 465 ASN A -3
REMARK 465 LYS A -2
REMARK 465 GLU A -1
REMARK 465 HIS A 0
REMARK 465 THR A 1
REMARK 465 SER A 2
REMARK 465 LYS A 3
REMARK 465 MET A 4
REMARK 465 VAL A 5
REMARK 465 SER A 6
REMARK 465 ALA A 7
REMARK 465 ILE A 8
REMARK 465 VAL A 9
REMARK 465 LEU A 10
REMARK 465 TYR A 11
REMARK 465 VAL A 12
REMARK 465 LEU A 13
REMARK 465 LEU A 14
REMARK 465 ALA A 15
REMARK 465 ALA A 16
REMARK 465 ALA A 17
REMARK 465 ALA A 18
REMARK 465 HIS A 19
REMARK 465 SER A 20
REMARK 465 ALA A 21
REMARK 465 PHE A 22
REMARK 465 ALA A 23
REMARK 465 ALA A 24
REMARK 465 ASP A 25
REMARK 465 MET A 26
REMARK 465 GLY A 27
REMARK 465 SER A 28
REMARK 465 ASN A 29
REMARK 465 LYS A 30
REMARK 465 GLY A 31
REMARK 465 THR A 32
REMARK 465 ASP A 33
REMARK 465 ASP A 34
REMARK 465 ALA A 35
REMARK 465 THR A 36
REMARK 465 ALA A 37
REMARK 465 ASP A 38
REMARK 465 GLY A 767
REMARK 465 SER A 768
REMARK 465 HIS A 769
REMARK 465 HIS A 770
REMARK 465 HIS A 771
REMARK 465 HIS A 772
REMARK 465 HIS A 773
REMARK 465 HIS A 774
REMARK 465 HIS A 775
REMARK 465 HIS A 776
REMARK 465 MET B -14
REMARK 465 LEU B -13
REMARK 465 LEU B -12
REMARK 465 VAL B -11
REMARK 465 ASN B -10
REMARK 465 GLN B -9
REMARK 465 SER B -8
REMARK 465 HIS B -7
REMARK 465 GLN B -6
REMARK 465 GLY B -5
REMARK 465 PHE B -4
REMARK 465 ASN B -3
REMARK 465 LYS B -2
REMARK 465 GLU B -1
REMARK 465 HIS B 0
REMARK 465 THR B 1
REMARK 465 SER B 2
REMARK 465 LYS B 3
REMARK 465 MET B 4
REMARK 465 VAL B 5
REMARK 465 SER B 6
REMARK 465 ALA B 7
REMARK 465 ILE B 8
REMARK 465 VAL B 9
REMARK 465 LEU B 10
REMARK 465 TYR B 11
REMARK 465 VAL B 12
REMARK 465 LEU B 13
REMARK 465 LEU B 14
REMARK 465 ALA B 15
REMARK 465 ALA B 16
REMARK 465 ALA B 17
REMARK 465 ALA B 18
REMARK 465 HIS B 19
REMARK 465 SER B 20
REMARK 465 ALA B 21
REMARK 465 PHE B 22
REMARK 465 ALA B 23
REMARK 465 ALA B 24
REMARK 465 ASP B 25
REMARK 465 MET B 26
REMARK 465 GLY B 27
REMARK 465 SER B 28
REMARK 465 ASN B 29
REMARK 465 LYS B 30
REMARK 465 GLY B 31
REMARK 465 THR B 32
REMARK 465 ASP B 33
REMARK 465 ASP B 34
REMARK 465 ALA B 35
REMARK 465 THR B 36
REMARK 465 ALA B 37
REMARK 465 ASP B 38
REMARK 465 GLY B 767
REMARK 465 SER B 768
REMARK 465 HIS B 769
REMARK 465 HIS B 770
REMARK 465 HIS B 771
REMARK 465 HIS B 772
REMARK 465 HIS B 773
REMARK 465 HIS B 774
REMARK 465 HIS B 775
REMARK 465 HIS B 776
REMARK 465 MET F 1
REMARK 465 ILE F 2
REMARK 465 HIS F 3
REMARK 465 SER F 4
REMARK 465 VAL F 5
REMARK 465 PHE F 6
REMARK 465 LEU F 7
REMARK 465 LEU F 8
REMARK 465 MET F 9
REMARK 465 PHE F 10
REMARK 465 LEU F 11
REMARK 465 LEU F 12
REMARK 465 THR F 13
REMARK 465 PRO F 14
REMARK 465 THR F 15
REMARK 465 GLU F 16
REMARK 465 SER F 17
REMARK 465 ASN F 1225
REMARK 465 SER F 1226
REMARK 465 THR F 1227
REMARK 465 GLY F 1228
REMARK 465 ILE F 1229
REMARK 465 ASP F 1230
REMARK 465 PHE F 1231
REMARK 465 GLN F 1232
REMARK 465 ASP F 1233
REMARK 465 GLU F 1234
REMARK 465 LEU F 1235
REMARK 465 ASP F 1236
REMARK 465 GLU F 1237
REMARK 465 PHE F 1238
REMARK 465 PHE F 1239
REMARK 465 LYS F 1240
REMARK 465 ASN F 1241
REMARK 465 VAL F 1242
REMARK 465 SER F 1243
REMARK 465 THR F 1244
REMARK 465 SER F 1245
REMARK 465 ILE F 1246
REMARK 465 PRO F 1247
REMARK 465 ASN F 1248
REMARK 465 PHE F 1249
REMARK 465 GLY F 1250
REMARK 465 SER F 1251
REMARK 465 LEU F 1252
REMARK 465 THR F 1253
REMARK 465 GLN F 1254
REMARK 465 ILE F 1255
REMARK 465 ASN F 1256
REMARK 465 THR F 1257
REMARK 465 THR F 1258
REMARK 465 LEU F 1259
REMARK 465 LEU F 1260
REMARK 465 ASP F 1261
REMARK 465 LEU F 1262
REMARK 465 THR F 1263
REMARK 465 TYR F 1264
REMARK 465 GLU F 1265
REMARK 465 MET F 1266
REMARK 465 LEU F 1267
REMARK 465 SER F 1268
REMARK 465 LEU F 1269
REMARK 465 GLN F 1270
REMARK 465 GLN F 1271
REMARK 465 VAL F 1272
REMARK 465 VAL F 1273
REMARK 465 LYS F 1274
REMARK 465 ALA F 1275
REMARK 465 LEU F 1276
REMARK 465 ASN F 1277
REMARK 465 GLU F 1278
REMARK 465 SER F 1279
REMARK 465 TYR F 1280
REMARK 465 ILE F 1281
REMARK 465 ASP F 1282
REMARK 465 LEU F 1283
REMARK 465 LYS F 1284
REMARK 465 GLU F 1285
REMARK 465 LEU F 1286
REMARK 465 GLY F 1287
REMARK 465 ASN F 1288
REMARK 465 TYR F 1289
REMARK 465 THR F 1290
REMARK 465 TYR F 1291
REMARK 465 GLY F 1292
REMARK 465 SER F 1293
REMARK 465 GLY F 1294
REMARK 465 TYR F 1295
REMARK 465 ILE F 1296
REMARK 465 PRO F 1297
REMARK 465 GLU F 1298
REMARK 465 ALA F 1299
REMARK 465 PRO F 1300
REMARK 465 ARG F 1301
REMARK 465 ASP F 1302
REMARK 465 GLY F 1303
REMARK 465 GLN F 1304
REMARK 465 ALA F 1305
REMARK 465 TYR F 1306
REMARK 465 VAL F 1307
REMARK 465 ARG F 1308
REMARK 465 LYS F 1309
REMARK 465 ASP F 1310
REMARK 465 GLY F 1311
REMARK 465 GLU F 1312
REMARK 465 TRP F 1313
REMARK 465 VAL F 1314
REMARK 465 LEU F 1315
REMARK 465 LEU F 1316
REMARK 465 SER F 1317
REMARK 465 THR F 1318
REMARK 465 PHE F 1319
REMARK 465 LEU F 1320
REMARK 465 GLY F 1321
REMARK 465 ARG F 1322
REMARK 465 SER F 1323
REMARK 465 LEU F 1324
REMARK 465 GLU F 1325
REMARK 465 VAL F 1326
REMARK 465 LEU F 1327
REMARK 465 PHE F 1328
REMARK 465 GLN F 1329
REMARK 465 GLY F 1330
REMARK 465 PRO F 1331
REMARK 465 GLY F 1332
REMARK 465 HIS F 1333
REMARK 465 HIS F 1334
REMARK 465 HIS F 1335
REMARK 465 HIS F 1336
REMARK 465 HIS F 1337
REMARK 465 HIS F 1338
REMARK 465 HIS F 1339
REMARK 465 HIS F 1340
REMARK 465 MET G 1
REMARK 465 ILE G 2
REMARK 465 HIS G 3
REMARK 465 SER G 4
REMARK 465 VAL G 5
REMARK 465 PHE G 6
REMARK 465 LEU G 7
REMARK 465 LEU G 8
REMARK 465 MET G 9
REMARK 465 PHE G 10
REMARK 465 LEU G 11
REMARK 465 LEU G 12
REMARK 465 THR G 13
REMARK 465 PRO G 14
REMARK 465 THR G 15
REMARK 465 GLU G 16
REMARK 465 SER G 17
REMARK 465 ASN G 1225
REMARK 465 SER G 1226
REMARK 465 THR G 1227
REMARK 465 GLY G 1228
REMARK 465 ILE G 1229
REMARK 465 ASP G 1230
REMARK 465 PHE G 1231
REMARK 465 GLN G 1232
REMARK 465 ASP G 1233
REMARK 465 GLU G 1234
REMARK 465 LEU G 1235
REMARK 465 ASP G 1236
REMARK 465 GLU G 1237
REMARK 465 PHE G 1238
REMARK 465 PHE G 1239
REMARK 465 LYS G 1240
REMARK 465 ASN G 1241
REMARK 465 VAL G 1242
REMARK 465 SER G 1243
REMARK 465 THR G 1244
REMARK 465 SER G 1245
REMARK 465 ILE G 1246
REMARK 465 PRO G 1247
REMARK 465 ASN G 1248
REMARK 465 PHE G 1249
REMARK 465 GLY G 1250
REMARK 465 SER G 1251
REMARK 465 LEU G 1252
REMARK 465 THR G 1253
REMARK 465 GLN G 1254
REMARK 465 ILE G 1255
REMARK 465 ASN G 1256
REMARK 465 THR G 1257
REMARK 465 THR G 1258
REMARK 465 LEU G 1259
REMARK 465 LEU G 1260
REMARK 465 ASP G 1261
REMARK 465 LEU G 1262
REMARK 465 THR G 1263
REMARK 465 TYR G 1264
REMARK 465 GLU G 1265
REMARK 465 MET G 1266
REMARK 465 LEU G 1267
REMARK 465 SER G 1268
REMARK 465 LEU G 1269
REMARK 465 GLN G 1270
REMARK 465 GLN G 1271
REMARK 465 VAL G 1272
REMARK 465 VAL G 1273
REMARK 465 LYS G 1274
REMARK 465 ALA G 1275
REMARK 465 LEU G 1276
REMARK 465 ASN G 1277
REMARK 465 GLU G 1278
REMARK 465 SER G 1279
REMARK 465 TYR G 1280
REMARK 465 ILE G 1281
REMARK 465 ASP G 1282
REMARK 465 LEU G 1283
REMARK 465 LYS G 1284
REMARK 465 GLU G 1285
REMARK 465 LEU G 1286
REMARK 465 GLY G 1287
REMARK 465 ASN G 1288
REMARK 465 TYR G 1289
REMARK 465 THR G 1290
REMARK 465 TYR G 1291
REMARK 465 GLY G 1292
REMARK 465 SER G 1293
REMARK 465 GLY G 1294
REMARK 465 TYR G 1295
REMARK 465 ILE G 1296
REMARK 465 PRO G 1297
REMARK 465 GLU G 1298
REMARK 465 ALA G 1299
REMARK 465 PRO G 1300
REMARK 465 ARG G 1301
REMARK 465 ASP G 1302
REMARK 465 GLY G 1303
REMARK 465 GLN G 1304
REMARK 465 ALA G 1305
REMARK 465 TYR G 1306
REMARK 465 VAL G 1307
REMARK 465 ARG G 1308
REMARK 465 LYS G 1309
REMARK 465 ASP G 1310
REMARK 465 GLY G 1311
REMARK 465 GLU G 1312
REMARK 465 TRP G 1313
REMARK 465 VAL G 1314
REMARK 465 LEU G 1315
REMARK 465 LEU G 1316
REMARK 465 SER G 1317
REMARK 465 THR G 1318
REMARK 465 PHE G 1319
REMARK 465 LEU G 1320
REMARK 465 GLY G 1321
REMARK 465 ARG G 1322
REMARK 465 SER G 1323
REMARK 465 LEU G 1324
REMARK 465 GLU G 1325
REMARK 465 VAL G 1326
REMARK 465 LEU G 1327
REMARK 465 PHE G 1328
REMARK 465 GLN G 1329
REMARK 465 GLY G 1330
REMARK 465 PRO G 1331
REMARK 465 GLY G 1332
REMARK 465 HIS G 1333
REMARK 465 HIS G 1334
REMARK 465 HIS G 1335
REMARK 465 HIS G 1336
REMARK 465 HIS G 1337
REMARK 465 HIS G 1338
REMARK 465 HIS G 1339
REMARK 465 HIS G 1340
REMARK 465 MET C 1
REMARK 465 ILE C 2
REMARK 465 HIS C 3
REMARK 465 SER C 4
REMARK 465 VAL C 5
REMARK 465 PHE C 6
REMARK 465 LEU C 7
REMARK 465 LEU C 8
REMARK 465 MET C 9
REMARK 465 PHE C 10
REMARK 465 LEU C 11
REMARK 465 LEU C 12
REMARK 465 THR C 13
REMARK 465 PRO C 14
REMARK 465 THR C 15
REMARK 465 GLU C 16
REMARK 465 SER C 17
REMARK 465 ASN C 1225
REMARK 465 SER C 1226
REMARK 465 THR C 1227
REMARK 465 GLY C 1228
REMARK 465 ILE C 1229
REMARK 465 ASP C 1230
REMARK 465 PHE C 1231
REMARK 465 GLN C 1232
REMARK 465 ASP C 1233
REMARK 465 GLU C 1234
REMARK 465 LEU C 1235
REMARK 465 ASP C 1236
REMARK 465 GLU C 1237
REMARK 465 PHE C 1238
REMARK 465 PHE C 1239
REMARK 465 LYS C 1240
REMARK 465 ASN C 1241
REMARK 465 VAL C 1242
REMARK 465 SER C 1243
REMARK 465 THR C 1244
REMARK 465 SER C 1245
REMARK 465 ILE C 1246
REMARK 465 PRO C 1247
REMARK 465 ASN C 1248
REMARK 465 PHE C 1249
REMARK 465 GLY C 1250
REMARK 465 SER C 1251
REMARK 465 LEU C 1252
REMARK 465 THR C 1253
REMARK 465 GLN C 1254
REMARK 465 ILE C 1255
REMARK 465 ASN C 1256
REMARK 465 THR C 1257
REMARK 465 THR C 1258
REMARK 465 LEU C 1259
REMARK 465 LEU C 1260
REMARK 465 ASP C 1261
REMARK 465 LEU C 1262
REMARK 465 THR C 1263
REMARK 465 TYR C 1264
REMARK 465 GLU C 1265
REMARK 465 MET C 1266
REMARK 465 LEU C 1267
REMARK 465 SER C 1268
REMARK 465 LEU C 1269
REMARK 465 GLN C 1270
REMARK 465 GLN C 1271
REMARK 465 VAL C 1272
REMARK 465 VAL C 1273
REMARK 465 LYS C 1274
REMARK 465 ALA C 1275
REMARK 465 LEU C 1276
REMARK 465 ASN C 1277
REMARK 465 GLU C 1278
REMARK 465 SER C 1279
REMARK 465 TYR C 1280
REMARK 465 ILE C 1281
REMARK 465 ASP C 1282
REMARK 465 LEU C 1283
REMARK 465 LYS C 1284
REMARK 465 GLU C 1285
REMARK 465 LEU C 1286
REMARK 465 GLY C 1287
REMARK 465 ASN C 1288
REMARK 465 TYR C 1289
REMARK 465 THR C 1290
REMARK 465 TYR C 1291
REMARK 465 GLY C 1292
REMARK 465 SER C 1293
REMARK 465 GLY C 1294
REMARK 465 TYR C 1295
REMARK 465 ILE C 1296
REMARK 465 PRO C 1297
REMARK 465 GLU C 1298
REMARK 465 ALA C 1299
REMARK 465 PRO C 1300
REMARK 465 ARG C 1301
REMARK 465 ASP C 1302
REMARK 465 GLY C 1303
REMARK 465 GLN C 1304
REMARK 465 ALA C 1305
REMARK 465 TYR C 1306
REMARK 465 VAL C 1307
REMARK 465 ARG C 1308
REMARK 465 LYS C 1309
REMARK 465 ASP C 1310
REMARK 465 GLY C 1311
REMARK 465 GLU C 1312
REMARK 465 TRP C 1313
REMARK 465 VAL C 1314
REMARK 465 LEU C 1315
REMARK 465 LEU C 1316
REMARK 465 SER C 1317
REMARK 465 THR C 1318
REMARK 465 PHE C 1319
REMARK 465 LEU C 1320
REMARK 465 GLY C 1321
REMARK 465 ARG C 1322
REMARK 465 SER C 1323
REMARK 465 LEU C 1324
REMARK 465 GLU C 1325
REMARK 465 VAL C 1326
REMARK 465 LEU C 1327
REMARK 465 PHE C 1328
REMARK 465 GLN C 1329
REMARK 465 GLY C 1330
REMARK 465 PRO C 1331
REMARK 465 GLY C 1332
REMARK 465 HIS C 1333
REMARK 465 HIS C 1334
REMARK 465 HIS C 1335
REMARK 465 HIS C 1336
REMARK 465 HIS C 1337
REMARK 465 HIS C 1338
REMARK 465 HIS C 1339
REMARK 465 HIS C 1340
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 TRP A 124 -169.85 -127.62
REMARK 500 ILE A 193 -59.35 -122.45
REMARK 500 LYS A 423 15.65 59.13
REMARK 500 ASN A 450 78.47 -159.54
REMARK 500 SER A 630 -5.96 71.52
REMARK 500 PRO A 674 48.91 -79.28
REMARK 500 ASP A 678 -60.92 -94.32
REMARK 500 ALA A 743 -9.71 -59.97
REMARK 500 TRP B 124 -169.21 -127.31
REMARK 500 ILE B 193 -56.37 -124.67
REMARK 500 VAL B 207 -60.49 -95.35
REMARK 500 ARG B 343 31.78 -98.50
REMARK 500 ASN B 450 76.91 -159.22
REMARK 500 SER B 630 -6.27 71.56
REMARK 500 TYR B 631 -30.02 -131.38
REMARK 500 SER B 686 31.77 -97.24
REMARK 500 ALA B 707 32.28 -98.47
REMARK 500 THR F 38 1.40 -68.77
REMARK 500 GLN F 98 -90.94 -117.98
REMARK 500 ALA F 103 -139.90 -95.61
REMARK 500 ASN F 104 59.20 -118.49
REMARK 500 LYS F 110 -169.02 -127.48
REMARK 500 ALA F 113 173.23 179.13
REMARK 500 ASN F 199 51.95 -91.48
REMARK 500 SER F 200 10.85 -142.46
REMARK 500 ASN F 222 31.92 -140.05
REMARK 500 GLN F 304 51.34 -91.93
REMARK 500 PHE F 341 -166.75 -126.86
REMARK 500 THR F 412 46.96 -82.56
REMARK 500 GLN F 427 46.84 -99.11
REMARK 500 PHE F 467 12.65 -142.24
REMARK 500 PRO F 531 -176.48 -69.48
REMARK 500 PRO F 586 -178.54 -67.01
REMARK 500 ASP F 593 54.21 -93.54
REMARK 500 TYR F 689 -167.58 -121.63
REMARK 500 TYR F 704 32.14 -99.61
REMARK 500 SER F 743 -70.71 -73.89
REMARK 500 SER F 752 37.15 -97.49
REMARK 500 GLN F 772 -178.50 -68.97
REMARK 500 PHE F 778 -7.85 71.65
REMARK 500 ILE F 782 64.11 32.36
REMARK 500 GLN F 826 59.13 -93.92
REMARK 500 PHE F1012 30.26 -94.13
REMARK 500 THR F1014 -4.37 69.18
REMARK 500 CYS F1117 56.85 -92.35
REMARK 500 SER F1144 -72.54 -64.22
REMARK 500 ASN F1145 -64.59 -124.35
REMARK 500 HIS F1146 171.43 177.61
REMARK 500 SER G 28 30.35 -96.46
REMARK 500 THR G 38 2.88 -69.16
REMARK 500
REMARK 500 THIS ENTRY HAS 111 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: EMD-68188 RELATED DB: EMDB
REMARK 900 CRYO-EM STRUCTURE OF MERS-COV S PROTEIN BOUND WITH RECEPTOR DPP4 IN
REMARK 900 THE CONFORMATION 1 (1 UP RBD AND 1 DPP4 BOUND).
DBREF 22DX A 29 766 UNP P27487 DPP4_HUMAN 29 766
DBREF 22DX B 29 766 UNP P27487 DPP4_HUMAN 29 766
DBREF 22DX F 1 1291 UNP K9N5Q8 SPIKE_MERS1 1 1291
DBREF 22DX G 1 1291 UNP K9N5Q8 SPIKE_MERS1 1 1291
DBREF 22DX C 1 1291 UNP K9N5Q8 SPIKE_MERS1 1 1291
SEQADV 22DX MET A -14 UNP P27487 INITIATING METHIONINE
SEQADV 22DX LEU A -13 UNP P27487 EXPRESSION TAG
SEQADV 22DX LEU A -12 UNP P27487 EXPRESSION TAG
SEQADV 22DX VAL A -11 UNP P27487 EXPRESSION TAG
SEQADV 22DX ASN A -10 UNP P27487 EXPRESSION TAG
SEQADV 22DX GLN A -9 UNP P27487 EXPRESSION TAG
SEQADV 22DX SER A -8 UNP P27487 EXPRESSION TAG
SEQADV 22DX HIS A -7 UNP P27487 EXPRESSION TAG
SEQADV 22DX GLN A -6 UNP P27487 EXPRESSION TAG
SEQADV 22DX GLY A -5 UNP P27487 EXPRESSION TAG
SEQADV 22DX PHE A -4 UNP P27487 EXPRESSION TAG
SEQADV 22DX ASN A -3 UNP P27487 EXPRESSION TAG
SEQADV 22DX LYS A -2 UNP P27487 EXPRESSION TAG
SEQADV 22DX GLU A -1 UNP P27487 EXPRESSION TAG
SEQADV 22DX HIS A 0 UNP P27487 EXPRESSION TAG
SEQADV 22DX THR A 1 UNP P27487 EXPRESSION TAG
SEQADV 22DX SER A 2 UNP P27487 EXPRESSION TAG
SEQADV 22DX LYS A 3 UNP P27487 EXPRESSION TAG
SEQADV 22DX MET A 4 UNP P27487 EXPRESSION TAG
SEQADV 22DX VAL A 5 UNP P27487 EXPRESSION TAG
SEQADV 22DX SER A 6 UNP P27487 EXPRESSION TAG
SEQADV 22DX ALA A 7 UNP P27487 EXPRESSION TAG
SEQADV 22DX ILE A 8 UNP P27487 EXPRESSION TAG
SEQADV 22DX VAL A 9 UNP P27487 EXPRESSION TAG
SEQADV 22DX LEU A 10 UNP P27487 EXPRESSION TAG
SEQADV 22DX TYR A 11 UNP P27487 EXPRESSION TAG
SEQADV 22DX VAL A 12 UNP P27487 EXPRESSION TAG
SEQADV 22DX LEU A 13 UNP P27487 EXPRESSION TAG
SEQADV 22DX LEU A 14 UNP P27487 EXPRESSION TAG
SEQADV 22DX ALA A 15 UNP P27487 EXPRESSION TAG
SEQADV 22DX ALA A 16 UNP P27487 EXPRESSION TAG
SEQADV 22DX ALA A 17 UNP P27487 EXPRESSION TAG
SEQADV 22DX ALA A 18 UNP P27487 EXPRESSION TAG
SEQADV 22DX HIS A 19 UNP P27487 EXPRESSION TAG
SEQADV 22DX SER A 20 UNP P27487 EXPRESSION TAG
SEQADV 22DX ALA A 21 UNP P27487 EXPRESSION TAG
SEQADV 22DX PHE A 22 UNP P27487 EXPRESSION TAG
SEQADV 22DX ALA A 23 UNP P27487 EXPRESSION TAG
SEQADV 22DX ALA A 24 UNP P27487 EXPRESSION TAG
SEQADV 22DX ASP A 25 UNP P27487 EXPRESSION TAG
SEQADV 22DX MET A 26 UNP P27487 EXPRESSION TAG
SEQADV 22DX GLY A 27 UNP P27487 EXPRESSION TAG
SEQADV 22DX SER A 28 UNP P27487 EXPRESSION TAG
SEQADV 22DX GLY A 767 UNP P27487 EXPRESSION TAG
SEQADV 22DX SER A 768 UNP P27487 EXPRESSION TAG
SEQADV 22DX HIS A 769 UNP P27487 EXPRESSION TAG
SEQADV 22DX HIS A 770 UNP P27487 EXPRESSION TAG
SEQADV 22DX HIS A 771 UNP P27487 EXPRESSION TAG
SEQADV 22DX HIS A 772 UNP P27487 EXPRESSION TAG
SEQADV 22DX HIS A 773 UNP P27487 EXPRESSION TAG
SEQADV 22DX HIS A 774 UNP P27487 EXPRESSION TAG
SEQADV 22DX HIS A 775 UNP P27487 EXPRESSION TAG
SEQADV 22DX HIS A 776 UNP P27487 EXPRESSION TAG
SEQADV 22DX MET B -14 UNP P27487 INITIATING METHIONINE
SEQADV 22DX LEU B -13 UNP P27487 EXPRESSION TAG
SEQADV 22DX LEU B -12 UNP P27487 EXPRESSION TAG
SEQADV 22DX VAL B -11 UNP P27487 EXPRESSION TAG
SEQADV 22DX ASN B -10 UNP P27487 EXPRESSION TAG
SEQADV 22DX GLN B -9 UNP P27487 EXPRESSION TAG
SEQADV 22DX SER B -8 UNP P27487 EXPRESSION TAG
SEQADV 22DX HIS B -7 UNP P27487 EXPRESSION TAG
SEQADV 22DX GLN B -6 UNP P27487 EXPRESSION TAG
SEQADV 22DX GLY B -5 UNP P27487 EXPRESSION TAG
SEQADV 22DX PHE B -4 UNP P27487 EXPRESSION TAG
SEQADV 22DX ASN B -3 UNP P27487 EXPRESSION TAG
SEQADV 22DX LYS B -2 UNP P27487 EXPRESSION TAG
SEQADV 22DX GLU B -1 UNP P27487 EXPRESSION TAG
SEQADV 22DX HIS B 0 UNP P27487 EXPRESSION TAG
SEQADV 22DX THR B 1 UNP P27487 EXPRESSION TAG
SEQADV 22DX SER B 2 UNP P27487 EXPRESSION TAG
SEQADV 22DX LYS B 3 UNP P27487 EXPRESSION TAG
SEQADV 22DX MET B 4 UNP P27487 EXPRESSION TAG
SEQADV 22DX VAL B 5 UNP P27487 EXPRESSION TAG
SEQADV 22DX SER B 6 UNP P27487 EXPRESSION TAG
SEQADV 22DX ALA B 7 UNP P27487 EXPRESSION TAG
SEQADV 22DX ILE B 8 UNP P27487 EXPRESSION TAG
SEQADV 22DX VAL B 9 UNP P27487 EXPRESSION TAG
SEQADV 22DX LEU B 10 UNP P27487 EXPRESSION TAG
SEQADV 22DX TYR B 11 UNP P27487 EXPRESSION TAG
SEQADV 22DX VAL B 12 UNP P27487 EXPRESSION TAG
SEQADV 22DX LEU B 13 UNP P27487 EXPRESSION TAG
SEQADV 22DX LEU B 14 UNP P27487 EXPRESSION TAG
SEQADV 22DX ALA B 15 UNP P27487 EXPRESSION TAG
SEQADV 22DX ALA B 16 UNP P27487 EXPRESSION TAG
SEQADV 22DX ALA B 17 UNP P27487 EXPRESSION TAG
SEQADV 22DX ALA B 18 UNP P27487 EXPRESSION TAG
SEQADV 22DX HIS B 19 UNP P27487 EXPRESSION TAG
SEQADV 22DX SER B 20 UNP P27487 EXPRESSION TAG
SEQADV 22DX ALA B 21 UNP P27487 EXPRESSION TAG
SEQADV 22DX PHE B 22 UNP P27487 EXPRESSION TAG
SEQADV 22DX ALA B 23 UNP P27487 EXPRESSION TAG
SEQADV 22DX ALA B 24 UNP P27487 EXPRESSION TAG
SEQADV 22DX ASP B 25 UNP P27487 EXPRESSION TAG
SEQADV 22DX MET B 26 UNP P27487 EXPRESSION TAG
SEQADV 22DX GLY B 27 UNP P27487 EXPRESSION TAG
SEQADV 22DX SER B 28 UNP P27487 EXPRESSION TAG
SEQADV 22DX GLY B 767 UNP P27487 EXPRESSION TAG
SEQADV 22DX SER B 768 UNP P27487 EXPRESSION TAG
SEQADV 22DX HIS B 769 UNP P27487 EXPRESSION TAG
SEQADV 22DX HIS B 770 UNP P27487 EXPRESSION TAG
SEQADV 22DX HIS B 771 UNP P27487 EXPRESSION TAG
SEQADV 22DX HIS B 772 UNP P27487 EXPRESSION TAG
SEQADV 22DX HIS B 773 UNP P27487 EXPRESSION TAG
SEQADV 22DX HIS B 774 UNP P27487 EXPRESSION TAG
SEQADV 22DX HIS B 775 UNP P27487 EXPRESSION TAG
SEQADV 22DX HIS B 776 UNP P27487 EXPRESSION TAG
SEQADV 22DX GLY F 1292 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX SER F 1293 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLY F 1294 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX TYR F 1295 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX ILE F 1296 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX PRO F 1297 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLU F 1298 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX ALA F 1299 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX PRO F 1300 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX ARG F 1301 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX ASP F 1302 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLY F 1303 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLN F 1304 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX ALA F 1305 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX TYR F 1306 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX VAL F 1307 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX ARG F 1308 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX LYS F 1309 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX ASP F 1310 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLY F 1311 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLU F 1312 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX TRP F 1313 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX VAL F 1314 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX LEU F 1315 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX LEU F 1316 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX SER F 1317 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX THR F 1318 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX PHE F 1319 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX LEU F 1320 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLY F 1321 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX ARG F 1322 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX SER F 1323 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX LEU F 1324 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLU F 1325 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX VAL F 1326 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX LEU F 1327 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX PHE F 1328 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLN F 1329 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLY F 1330 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX PRO F 1331 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLY F 1332 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX HIS F 1333 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX HIS F 1334 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX HIS F 1335 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX HIS F 1336 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX HIS F 1337 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX HIS F 1338 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX HIS F 1339 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX HIS F 1340 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLY G 1292 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX SER G 1293 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLY G 1294 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX TYR G 1295 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX ILE G 1296 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX PRO G 1297 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLU G 1298 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX ALA G 1299 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX PRO G 1300 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX ARG G 1301 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX ASP G 1302 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLY G 1303 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLN G 1304 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX ALA G 1305 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX TYR G 1306 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX VAL G 1307 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX ARG G 1308 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX LYS G 1309 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX ASP G 1310 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLY G 1311 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLU G 1312 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX TRP G 1313 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX VAL G 1314 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX LEU G 1315 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX LEU G 1316 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX SER G 1317 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX THR G 1318 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX PHE G 1319 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX LEU G 1320 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLY G 1321 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX ARG G 1322 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX SER G 1323 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX LEU G 1324 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLU G 1325 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX VAL G 1326 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX LEU G 1327 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX PHE G 1328 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLN G 1329 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLY G 1330 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX PRO G 1331 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLY G 1332 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX HIS G 1333 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX HIS G 1334 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX HIS G 1335 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX HIS G 1336 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX HIS G 1337 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX HIS G 1338 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX HIS G 1339 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX HIS G 1340 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLY C 1292 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX SER C 1293 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLY C 1294 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX TYR C 1295 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX ILE C 1296 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX PRO C 1297 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLU C 1298 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX ALA C 1299 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX PRO C 1300 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX ARG C 1301 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX ASP C 1302 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLY C 1303 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLN C 1304 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX ALA C 1305 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX TYR C 1306 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX VAL C 1307 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX ARG C 1308 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX LYS C 1309 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX ASP C 1310 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLY C 1311 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLU C 1312 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX TRP C 1313 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX VAL C 1314 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX LEU C 1315 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX LEU C 1316 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX SER C 1317 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX THR C 1318 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX PHE C 1319 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX LEU C 1320 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLY C 1321 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX ARG C 1322 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX SER C 1323 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX LEU C 1324 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLU C 1325 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX VAL C 1326 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX LEU C 1327 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX PHE C 1328 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLN C 1329 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLY C 1330 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX PRO C 1331 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX GLY C 1332 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX HIS C 1333 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX HIS C 1334 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX HIS C 1335 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX HIS C 1336 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX HIS C 1337 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX HIS C 1338 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX HIS C 1339 UNP K9N5Q8 EXPRESSION TAG
SEQADV 22DX HIS C 1340 UNP K9N5Q8 EXPRESSION TAG
SEQRES 1 A 791 MET LEU LEU VAL ASN GLN SER HIS GLN GLY PHE ASN LYS
SEQRES 2 A 791 GLU HIS THR SER LYS MET VAL SER ALA ILE VAL LEU TYR
SEQRES 3 A 791 VAL LEU LEU ALA ALA ALA ALA HIS SER ALA PHE ALA ALA
SEQRES 4 A 791 ASP MET GLY SER ASN LYS GLY THR ASP ASP ALA THR ALA
SEQRES 5 A 791 ASP SER ARG LYS THR TYR THR LEU THR ASP TYR LEU LYS
SEQRES 6 A 791 ASN THR TYR ARG LEU LYS LEU TYR SER LEU ARG TRP ILE
SEQRES 7 A 791 SER ASP HIS GLU TYR LEU TYR LYS GLN GLU ASN ASN ILE
SEQRES 8 A 791 LEU VAL PHE ASN ALA GLU TYR GLY ASN SER SER VAL PHE
SEQRES 9 A 791 LEU GLU ASN SER THR PHE ASP GLU PHE GLY HIS SER ILE
SEQRES 10 A 791 ASN ASP TYR SER ILE SER PRO ASP GLY GLN PHE ILE LEU
SEQRES 11 A 791 LEU GLU TYR ASN TYR VAL LYS GLN TRP ARG HIS SER TYR
SEQRES 12 A 791 THR ALA SER TYR ASP ILE TYR ASP LEU ASN LYS ARG GLN
SEQRES 13 A 791 LEU ILE THR GLU GLU ARG ILE PRO ASN ASN THR GLN TRP
SEQRES 14 A 791 VAL THR TRP SER PRO VAL GLY HIS LYS LEU ALA TYR VAL
SEQRES 15 A 791 TRP ASN ASN ASP ILE TYR VAL LYS ILE GLU PRO ASN LEU
SEQRES 16 A 791 PRO SER TYR ARG ILE THR TRP THR GLY LYS GLU ASP ILE
SEQRES 17 A 791 ILE TYR ASN GLY ILE THR ASP TRP VAL TYR GLU GLU GLU
SEQRES 18 A 791 VAL PHE SER ALA TYR SER ALA LEU TRP TRP SER PRO ASN
SEQRES 19 A 791 GLY THR PHE LEU ALA TYR ALA GLN PHE ASN ASP THR GLU
SEQRES 20 A 791 VAL PRO LEU ILE GLU TYR SER PHE TYR SER ASP GLU SER
SEQRES 21 A 791 LEU GLN TYR PRO LYS THR VAL ARG VAL PRO TYR PRO LYS
SEQRES 22 A 791 ALA GLY ALA VAL ASN PRO THR VAL LYS PHE PHE VAL VAL
SEQRES 23 A 791 ASN THR ASP SER LEU SER SER VAL THR ASN ALA THR SER
SEQRES 24 A 791 ILE GLN ILE THR ALA PRO ALA SER MET LEU ILE GLY ASP
SEQRES 25 A 791 HIS TYR LEU CYS ASP VAL THR TRP ALA THR GLN GLU ARG
SEQRES 26 A 791 ILE SER LEU GLN TRP LEU ARG ARG ILE GLN ASN TYR SER
SEQRES 27 A 791 VAL MET ASP ILE CYS ASP TYR ASP GLU SER SER GLY ARG
SEQRES 28 A 791 TRP ASN CYS LEU VAL ALA ARG GLN HIS ILE GLU MET SER
SEQRES 29 A 791 THR THR GLY TRP VAL GLY ARG PHE ARG PRO SER GLU PRO
SEQRES 30 A 791 HIS PHE THR LEU ASP GLY ASN SER PHE TYR LYS ILE ILE
SEQRES 31 A 791 SER ASN GLU GLU GLY TYR ARG HIS ILE CYS TYR PHE GLN
SEQRES 32 A 791 ILE ASP LYS LYS ASP CYS THR PHE ILE THR LYS GLY THR
SEQRES 33 A 791 TRP GLU VAL ILE GLY ILE GLU ALA LEU THR SER ASP TYR
SEQRES 34 A 791 LEU TYR TYR ILE SER ASN GLU TYR LYS GLY MET PRO GLY
SEQRES 35 A 791 GLY ARG ASN LEU TYR LYS ILE GLN LEU SER ASP TYR THR
SEQRES 36 A 791 LYS VAL THR CYS LEU SER CYS GLU LEU ASN PRO GLU ARG
SEQRES 37 A 791 CYS GLN TYR TYR SER VAL SER PHE SER LYS GLU ALA LYS
SEQRES 38 A 791 TYR TYR GLN LEU ARG CYS SER GLY PRO GLY LEU PRO LEU
SEQRES 39 A 791 TYR THR LEU HIS SER SER VAL ASN ASP LYS GLY LEU ARG
SEQRES 40 A 791 VAL LEU GLU ASP ASN SER ALA LEU ASP LYS MET LEU GLN
SEQRES 41 A 791 ASN VAL GLN MET PRO SER LYS LYS LEU ASP PHE ILE ILE
SEQRES 42 A 791 LEU ASN GLU THR LYS PHE TRP TYR GLN MET ILE LEU PRO
SEQRES 43 A 791 PRO HIS PHE ASP LYS SER LYS LYS TYR PRO LEU LEU LEU
SEQRES 44 A 791 ASP VAL TYR ALA GLY PRO CYS SER GLN LYS ALA ASP THR
SEQRES 45 A 791 VAL PHE ARG LEU ASN TRP ALA THR TYR LEU ALA SER THR
SEQRES 46 A 791 GLU ASN ILE ILE VAL ALA SER PHE ASP GLY ARG GLY SER
SEQRES 47 A 791 GLY TYR GLN GLY ASP LYS ILE MET HIS ALA ILE ASN ARG
SEQRES 48 A 791 ARG LEU GLY THR PHE GLU VAL GLU ASP GLN ILE GLU ALA
SEQRES 49 A 791 ALA ARG GLN PHE SER LYS MET GLY PHE VAL ASP ASN LYS
SEQRES 50 A 791 ARG ILE ALA ILE TRP GLY TRP SER TYR GLY GLY TYR VAL
SEQRES 51 A 791 THR SER MET VAL LEU GLY SER GLY SER GLY VAL PHE LYS
SEQRES 52 A 791 CYS GLY ILE ALA VAL ALA PRO VAL SER ARG TRP GLU TYR
SEQRES 53 A 791 TYR ASP SER VAL TYR THR GLU ARG TYR MET GLY LEU PRO
SEQRES 54 A 791 THR PRO GLU ASP ASN LEU ASP HIS TYR ARG ASN SER THR
SEQRES 55 A 791 VAL MET SER ARG ALA GLU ASN PHE LYS GLN VAL GLU TYR
SEQRES 56 A 791 LEU LEU ILE HIS GLY THR ALA ASP ASP ASN VAL HIS PHE
SEQRES 57 A 791 GLN GLN SER ALA GLN ILE SER LYS ALA LEU VAL ASP VAL
SEQRES 58 A 791 GLY VAL ASP PHE GLN ALA MET TRP TYR THR ASP GLU ASP
SEQRES 59 A 791 HIS GLY ILE ALA SER SER THR ALA HIS GLN HIS ILE TYR
SEQRES 60 A 791 THR HIS MET SER HIS PHE ILE LYS GLN CYS PHE SER LEU
SEQRES 61 A 791 PRO GLY SER HIS HIS HIS HIS HIS HIS HIS HIS
SEQRES 1 B 791 MET LEU LEU VAL ASN GLN SER HIS GLN GLY PHE ASN LYS
SEQRES 2 B 791 GLU HIS THR SER LYS MET VAL SER ALA ILE VAL LEU TYR
SEQRES 3 B 791 VAL LEU LEU ALA ALA ALA ALA HIS SER ALA PHE ALA ALA
SEQRES 4 B 791 ASP MET GLY SER ASN LYS GLY THR ASP ASP ALA THR ALA
SEQRES 5 B 791 ASP SER ARG LYS THR TYR THR LEU THR ASP TYR LEU LYS
SEQRES 6 B 791 ASN THR TYR ARG LEU LYS LEU TYR SER LEU ARG TRP ILE
SEQRES 7 B 791 SER ASP HIS GLU TYR LEU TYR LYS GLN GLU ASN ASN ILE
SEQRES 8 B 791 LEU VAL PHE ASN ALA GLU TYR GLY ASN SER SER VAL PHE
SEQRES 9 B 791 LEU GLU ASN SER THR PHE ASP GLU PHE GLY HIS SER ILE
SEQRES 10 B 791 ASN ASP TYR SER ILE SER PRO ASP GLY GLN PHE ILE LEU
SEQRES 11 B 791 LEU GLU TYR ASN TYR VAL LYS GLN TRP ARG HIS SER TYR
SEQRES 12 B 791 THR ALA SER TYR ASP ILE TYR ASP LEU ASN LYS ARG GLN
SEQRES 13 B 791 LEU ILE THR GLU GLU ARG ILE PRO ASN ASN THR GLN TRP
SEQRES 14 B 791 VAL THR TRP SER PRO VAL GLY HIS LYS LEU ALA TYR VAL
SEQRES 15 B 791 TRP ASN ASN ASP ILE TYR VAL LYS ILE GLU PRO ASN LEU
SEQRES 16 B 791 PRO SER TYR ARG ILE THR TRP THR GLY LYS GLU ASP ILE
SEQRES 17 B 791 ILE TYR ASN GLY ILE THR ASP TRP VAL TYR GLU GLU GLU
SEQRES 18 B 791 VAL PHE SER ALA TYR SER ALA LEU TRP TRP SER PRO ASN
SEQRES 19 B 791 GLY THR PHE LEU ALA TYR ALA GLN PHE ASN ASP THR GLU
SEQRES 20 B 791 VAL PRO LEU ILE GLU TYR SER PHE TYR SER ASP GLU SER
SEQRES 21 B 791 LEU GLN TYR PRO LYS THR VAL ARG VAL PRO TYR PRO LYS
SEQRES 22 B 791 ALA GLY ALA VAL ASN PRO THR VAL LYS PHE PHE VAL VAL
SEQRES 23 B 791 ASN THR ASP SER LEU SER SER VAL THR ASN ALA THR SER
SEQRES 24 B 791 ILE GLN ILE THR ALA PRO ALA SER MET LEU ILE GLY ASP
SEQRES 25 B 791 HIS TYR LEU CYS ASP VAL THR TRP ALA THR GLN GLU ARG
SEQRES 26 B 791 ILE SER LEU GLN TRP LEU ARG ARG ILE GLN ASN TYR SER
SEQRES 27 B 791 VAL MET ASP ILE CYS ASP TYR ASP GLU SER SER GLY ARG
SEQRES 28 B 791 TRP ASN CYS LEU VAL ALA ARG GLN HIS ILE GLU MET SER
SEQRES 29 B 791 THR THR GLY TRP VAL GLY ARG PHE ARG PRO SER GLU PRO
SEQRES 30 B 791 HIS PHE THR LEU ASP GLY ASN SER PHE TYR LYS ILE ILE
SEQRES 31 B 791 SER ASN GLU GLU GLY TYR ARG HIS ILE CYS TYR PHE GLN
SEQRES 32 B 791 ILE ASP LYS LYS ASP CYS THR PHE ILE THR LYS GLY THR
SEQRES 33 B 791 TRP GLU VAL ILE GLY ILE GLU ALA LEU THR SER ASP TYR
SEQRES 34 B 791 LEU TYR TYR ILE SER ASN GLU TYR LYS GLY MET PRO GLY
SEQRES 35 B 791 GLY ARG ASN LEU TYR LYS ILE GLN LEU SER ASP TYR THR
SEQRES 36 B 791 LYS VAL THR CYS LEU SER CYS GLU LEU ASN PRO GLU ARG
SEQRES 37 B 791 CYS GLN TYR TYR SER VAL SER PHE SER LYS GLU ALA LYS
SEQRES 38 B 791 TYR TYR GLN LEU ARG CYS SER GLY PRO GLY LEU PRO LEU
SEQRES 39 B 791 TYR THR LEU HIS SER SER VAL ASN ASP LYS GLY LEU ARG
SEQRES 40 B 791 VAL LEU GLU ASP ASN SER ALA LEU ASP LYS MET LEU GLN
SEQRES 41 B 791 ASN VAL GLN MET PRO SER LYS LYS LEU ASP PHE ILE ILE
SEQRES 42 B 791 LEU ASN GLU THR LYS PHE TRP TYR GLN MET ILE LEU PRO
SEQRES 43 B 791 PRO HIS PHE ASP LYS SER LYS LYS TYR PRO LEU LEU LEU
SEQRES 44 B 791 ASP VAL TYR ALA GLY PRO CYS SER GLN LYS ALA ASP THR
SEQRES 45 B 791 VAL PHE ARG LEU ASN TRP ALA THR TYR LEU ALA SER THR
SEQRES 46 B 791 GLU ASN ILE ILE VAL ALA SER PHE ASP GLY ARG GLY SER
SEQRES 47 B 791 GLY TYR GLN GLY ASP LYS ILE MET HIS ALA ILE ASN ARG
SEQRES 48 B 791 ARG LEU GLY THR PHE GLU VAL GLU ASP GLN ILE GLU ALA
SEQRES 49 B 791 ALA ARG GLN PHE SER LYS MET GLY PHE VAL ASP ASN LYS
SEQRES 50 B 791 ARG ILE ALA ILE TRP GLY TRP SER TYR GLY GLY TYR VAL
SEQRES 51 B 791 THR SER MET VAL LEU GLY SER GLY SER GLY VAL PHE LYS
SEQRES 52 B 791 CYS GLY ILE ALA VAL ALA PRO VAL SER ARG TRP GLU TYR
SEQRES 53 B 791 TYR ASP SER VAL TYR THR GLU ARG TYR MET GLY LEU PRO
SEQRES 54 B 791 THR PRO GLU ASP ASN LEU ASP HIS TYR ARG ASN SER THR
SEQRES 55 B 791 VAL MET SER ARG ALA GLU ASN PHE LYS GLN VAL GLU TYR
SEQRES 56 B 791 LEU LEU ILE HIS GLY THR ALA ASP ASP ASN VAL HIS PHE
SEQRES 57 B 791 GLN GLN SER ALA GLN ILE SER LYS ALA LEU VAL ASP VAL
SEQRES 58 B 791 GLY VAL ASP PHE GLN ALA MET TRP TYR THR ASP GLU ASP
SEQRES 59 B 791 HIS GLY ILE ALA SER SER THR ALA HIS GLN HIS ILE TYR
SEQRES 60 B 791 THR HIS MET SER HIS PHE ILE LYS GLN CYS PHE SER LEU
SEQRES 61 B 791 PRO GLY SER HIS HIS HIS HIS HIS HIS HIS HIS
SEQRES 1 F 1340 MET ILE HIS SER VAL PHE LEU LEU MET PHE LEU LEU THR
SEQRES 2 F 1340 PRO THR GLU SER TYR VAL ASP VAL GLY PRO ASP SER VAL
SEQRES 3 F 1340 LYS SER ALA CYS ILE GLU VAL ASP ILE GLN GLN THR PHE
SEQRES 4 F 1340 PHE ASP LYS THR TRP PRO ARG PRO ILE ASP VAL SER LYS
SEQRES 5 F 1340 ALA ASP GLY ILE ILE TYR PRO GLN GLY ARG THR TYR SER
SEQRES 6 F 1340 ASN ILE THR ILE THR TYR GLN GLY LEU PHE PRO TYR GLN
SEQRES 7 F 1340 GLY ASP HIS GLY ASP MET TYR VAL TYR SER ALA GLY HIS
SEQRES 8 F 1340 ALA THR GLY THR THR PRO GLN LYS LEU PHE VAL ALA ASN
SEQRES 9 F 1340 TYR SER GLN ASP VAL LYS GLN PHE ALA ASN GLY PHE VAL
SEQRES 10 F 1340 VAL ARG ILE GLY ALA ALA ALA ASN SER THR GLY THR VAL
SEQRES 11 F 1340 ILE ILE SER PRO SER THR SER ALA THR ILE ARG LYS ILE
SEQRES 12 F 1340 TYR PRO ALA PHE MET LEU GLY SER SER VAL GLY ASN PHE
SEQRES 13 F 1340 SER ASP GLY LYS MET GLY ARG PHE PHE ASN HIS THR LEU
SEQRES 14 F 1340 VAL LEU LEU PRO ASP GLY CYS GLY THR LEU LEU ARG ALA
SEQRES 15 F 1340 PHE TYR CYS ILE LEU GLU PRO ARG SER GLY ASN HIS CYS
SEQRES 16 F 1340 PRO ALA GLY ASN SER TYR THR SER PHE ALA THR TYR HIS
SEQRES 17 F 1340 THR PRO ALA THR ASP CYS SER ASP GLY ASN TYR ASN ARG
SEQRES 18 F 1340 ASN ALA SER LEU ASN SER PHE LYS GLU TYR PHE ASN LEU
SEQRES 19 F 1340 ARG ASN CYS THR PHE MET TYR THR TYR ASN ILE THR GLU
SEQRES 20 F 1340 ASP GLU ILE LEU GLU TRP PHE GLY ILE THR GLN THR ALA
SEQRES 21 F 1340 GLN GLY VAL HIS LEU PHE SER SER ARG TYR VAL ASP LEU
SEQRES 22 F 1340 TYR GLY GLY ASN MET PHE GLN PHE ALA THR LEU PRO VAL
SEQRES 23 F 1340 TYR ASP THR ILE LYS TYR TYR SER ILE ILE PRO HIS SER
SEQRES 24 F 1340 ILE ARG SER ILE GLN SER ASP ARG LYS ALA TRP ALA ALA
SEQRES 25 F 1340 PHE TYR VAL TYR LYS LEU GLN PRO LEU THR PHE LEU LEU
SEQRES 26 F 1340 ASP PHE SER VAL ASP GLY TYR ILE ARG ARG ALA ILE ASP
SEQRES 27 F 1340 CYS GLY PHE ASN ASP LEU SER GLN LEU HIS CYS SER TYR
SEQRES 28 F 1340 GLU SER PHE ASP VAL GLU SER GLY VAL TYR SER VAL SER
SEQRES 29 F 1340 SER PHE GLU ALA LYS PRO SER GLY SER VAL VAL GLU GLN
SEQRES 30 F 1340 ALA GLU GLY VAL GLU CYS ASP PHE SER PRO LEU LEU SER
SEQRES 31 F 1340 GLY THR PRO PRO GLN VAL TYR ASN PHE LYS ARG LEU VAL
SEQRES 32 F 1340 PHE THR ASN CYS ASN TYR ASN LEU THR LYS LEU LEU SER
SEQRES 33 F 1340 LEU PHE SER VAL ASN ASP PHE THR CYS SER GLN ILE SER
SEQRES 34 F 1340 PRO ALA ALA ILE ALA SER ASN CYS TYR SER SER LEU ILE
SEQRES 35 F 1340 LEU ASP TYR PHE SER TYR PRO LEU SER MET LYS SER ASP
SEQRES 36 F 1340 LEU SER VAL SER SER ALA GLY PRO ILE SER GLN PHE ASN
SEQRES 37 F 1340 TYR LYS GLN SER PHE SER ASN PRO THR CYS LEU ILE LEU
SEQRES 38 F 1340 ALA THR VAL PRO HIS ASN LEU THR THR ILE THR LYS PRO
SEQRES 39 F 1340 LEU LYS TYR SER TYR ILE ASN LYS CYS SER ARG PHE LEU
SEQRES 40 F 1340 SER ASP ASP ARG THR GLU VAL PRO GLN LEU VAL ASN ALA
SEQRES 41 F 1340 ASN GLN TYR SER PRO CYS VAL SER ILE VAL PRO SER THR
SEQRES 42 F 1340 VAL TRP GLU ASP GLY ASP TYR TYR ARG LYS GLN LEU SER
SEQRES 43 F 1340 PRO LEU GLU GLY GLY GLY TRP LEU VAL ALA SER GLY SER
SEQRES 44 F 1340 THR VAL ALA MET THR GLU GLN LEU GLN MET GLY PHE GLY
SEQRES 45 F 1340 ILE THR VAL GLN TYR GLY THR ASP THR ASN SER VAL CYS
SEQRES 46 F 1340 PRO LYS LEU GLU PHE ALA ASN ASP THR LYS ILE ALA SER
SEQRES 47 F 1340 GLN LEU GLY ASN CYS VAL GLU TYR SER LEU TYR GLY VAL
SEQRES 48 F 1340 SER GLY ARG GLY VAL PHE GLN ASN CYS THR ALA VAL GLY
SEQRES 49 F 1340 VAL ARG GLN GLN ARG PHE VAL TYR ASP ALA TYR GLN ASN
SEQRES 50 F 1340 LEU VAL GLY TYR TYR SER ASP ASP GLY ASN TYR TYR CYS
SEQRES 51 F 1340 LEU ARG ALA CYS VAL SER VAL PRO VAL SER VAL ILE TYR
SEQRES 52 F 1340 ASP LYS GLU THR LYS THR HIS ALA THR LEU PHE GLY SER
SEQRES 53 F 1340 VAL ALA CYS GLU HIS ILE SER SER THR MET SER GLN TYR
SEQRES 54 F 1340 SER ARG SER THR ARG SER MET LEU LYS ARG ARG ASP SER
SEQRES 55 F 1340 THR TYR GLY PRO LEU GLN THR PRO VAL GLY CYS VAL LEU
SEQRES 56 F 1340 GLY LEU VAL ASN SER SER LEU PHE VAL GLU ASP CYS LYS
SEQRES 57 F 1340 LEU PRO LEU GLY GLN SER LEU CYS ALA LEU PRO ASP THR
SEQRES 58 F 1340 PRO SER THR LEU THR PRO ARG SER VAL ARG SER VAL PRO
SEQRES 59 F 1340 GLY GLU MET ARG LEU ALA SER ILE ALA PHE ASN HIS PRO
SEQRES 60 F 1340 ILE GLN VAL ASP GLN LEU ASN SER SER TYR PHE LYS LEU
SEQRES 61 F 1340 SER ILE PRO THR ASN PHE SER PHE GLY VAL THR GLN GLU
SEQRES 62 F 1340 TYR ILE GLN THR THR ILE GLN LYS VAL THR VAL ASP CYS
SEQRES 63 F 1340 LYS GLN TYR VAL CYS ASN GLY PHE GLN LYS CYS GLU GLN
SEQRES 64 F 1340 LEU LEU ARG GLU TYR GLY GLN PHE CYS SER LYS ILE ASN
SEQRES 65 F 1340 GLN ALA LEU HIS GLY ALA ASN LEU ARG GLN ASP ASP SER
SEQRES 66 F 1340 VAL ARG ASN LEU PHE ALA SER VAL LYS SER SER GLN SER
SEQRES 67 F 1340 SER PRO ILE ILE PRO GLY PHE GLY GLY ASP PHE ASN LEU
SEQRES 68 F 1340 THR LEU LEU GLU PRO VAL SER ILE SER THR GLY SER ARG
SEQRES 69 F 1340 SER ALA ARG SER ALA ILE GLU ASP LEU LEU PHE ASP LYS
SEQRES 70 F 1340 VAL THR ILE ALA ASP PRO GLY TYR MET GLN GLY TYR ASP
SEQRES 71 F 1340 ASP CYS MET GLN GLN GLY PRO ALA SER ALA ARG ASP LEU
SEQRES 72 F 1340 ILE CYS ALA GLN TYR VAL ALA GLY TYR LYS VAL LEU PRO
SEQRES 73 F 1340 PRO LEU MET ASP VAL ASN MET GLU ALA ALA TYR THR SER
SEQRES 74 F 1340 SER LEU LEU GLY SER ILE ALA GLY VAL GLY TRP THR ALA
SEQRES 75 F 1340 GLY LEU SER SER PHE ALA ALA ILE PRO PHE ALA GLN SER
SEQRES 76 F 1340 ILE PHE TYR ARG LEU ASN GLY VAL GLY ILE THR GLN GLN
SEQRES 77 F 1340 VAL LEU SER GLU ASN GLN LYS LEU ILE ALA ASN LYS PHE
SEQRES 78 F 1340 ASN GLN ALA LEU GLY ALA MET GLN THR GLY PHE THR THR
SEQRES 79 F 1340 THR ASN GLU ALA PHE HIS LYS VAL GLN ASP ALA VAL ASN
SEQRES 80 F 1340 ASN ASN ALA GLN ALA LEU SER LYS LEU ALA SER GLU LEU
SEQRES 81 F 1340 SER ASN THR PHE GLY ALA ILE SER ALA SER ILE GLY ASP
SEQRES 82 F 1340 ILE ILE GLN ARG LEU ASP VAL LEU GLU GLN ASP ALA GLN
SEQRES 83 F 1340 ILE ASP ARG LEU ILE ASN GLY ARG LEU THR THR LEU ASN
SEQRES 84 F 1340 ALA PHE VAL ALA GLN GLN LEU VAL ARG SER GLU SER ALA
SEQRES 85 F 1340 ALA LEU SER ALA GLN LEU ALA LYS ASP LYS VAL ASN GLU
SEQRES 86 F 1340 CYS VAL LYS ALA GLN SER LYS ARG SER GLY PHE CYS GLY
SEQRES 87 F 1340 GLN GLY THR HIS ILE VAL SER PHE VAL VAL ASN ALA PRO
SEQRES 88 F 1340 ASN GLY LEU TYR PHE MET HIS VAL GLY TYR TYR PRO SER
SEQRES 89 F 1340 ASN HIS ILE GLU VAL VAL SER ALA TYR GLY LEU CYS ASP
SEQRES 90 F 1340 ALA ALA ASN PRO THR ASN CYS ILE ALA PRO VAL ASN GLY
SEQRES 91 F 1340 TYR PHE ILE LYS THR ASN ASN THR ARG ILE VAL ASP GLU
SEQRES 92 F 1340 TRP SER TYR THR GLY SER SER PHE TYR ALA PRO GLU PRO
SEQRES 93 F 1340 ILE THR SER LEU ASN THR LYS TYR VAL ALA PRO GLN VAL
SEQRES 94 F 1340 THR TYR GLN ASN ILE SER THR ASN LEU PRO PRO PRO LEU
SEQRES 95 F 1340 LEU GLY ASN SER THR GLY ILE ASP PHE GLN ASP GLU LEU
SEQRES 96 F 1340 ASP GLU PHE PHE LYS ASN VAL SER THR SER ILE PRO ASN
SEQRES 97 F 1340 PHE GLY SER LEU THR GLN ILE ASN THR THR LEU LEU ASP
SEQRES 98 F 1340 LEU THR TYR GLU MET LEU SER LEU GLN GLN VAL VAL LYS
SEQRES 99 F 1340 ALA LEU ASN GLU SER TYR ILE ASP LEU LYS GLU LEU GLY
SEQRES 100 F 1340 ASN TYR THR TYR GLY SER GLY TYR ILE PRO GLU ALA PRO
SEQRES 101 F 1340 ARG ASP GLY GLN ALA TYR VAL ARG LYS ASP GLY GLU TRP
SEQRES 102 F 1340 VAL LEU LEU SER THR PHE LEU GLY ARG SER LEU GLU VAL
SEQRES 103 F 1340 LEU PHE GLN GLY PRO GLY HIS HIS HIS HIS HIS HIS HIS
SEQRES 104 F 1340 HIS
SEQRES 1 G 1340 MET ILE HIS SER VAL PHE LEU LEU MET PHE LEU LEU THR
SEQRES 2 G 1340 PRO THR GLU SER TYR VAL ASP VAL GLY PRO ASP SER VAL
SEQRES 3 G 1340 LYS SER ALA CYS ILE GLU VAL ASP ILE GLN GLN THR PHE
SEQRES 4 G 1340 PHE ASP LYS THR TRP PRO ARG PRO ILE ASP VAL SER LYS
SEQRES 5 G 1340 ALA ASP GLY ILE ILE TYR PRO GLN GLY ARG THR TYR SER
SEQRES 6 G 1340 ASN ILE THR ILE THR TYR GLN GLY LEU PHE PRO TYR GLN
SEQRES 7 G 1340 GLY ASP HIS GLY ASP MET TYR VAL TYR SER ALA GLY HIS
SEQRES 8 G 1340 ALA THR GLY THR THR PRO GLN LYS LEU PHE VAL ALA ASN
SEQRES 9 G 1340 TYR SER GLN ASP VAL LYS GLN PHE ALA ASN GLY PHE VAL
SEQRES 10 G 1340 VAL ARG ILE GLY ALA ALA ALA ASN SER THR GLY THR VAL
SEQRES 11 G 1340 ILE ILE SER PRO SER THR SER ALA THR ILE ARG LYS ILE
SEQRES 12 G 1340 TYR PRO ALA PHE MET LEU GLY SER SER VAL GLY ASN PHE
SEQRES 13 G 1340 SER ASP GLY LYS MET GLY ARG PHE PHE ASN HIS THR LEU
SEQRES 14 G 1340 VAL LEU LEU PRO ASP GLY CYS GLY THR LEU LEU ARG ALA
SEQRES 15 G 1340 PHE TYR CYS ILE LEU GLU PRO ARG SER GLY ASN HIS CYS
SEQRES 16 G 1340 PRO ALA GLY ASN SER TYR THR SER PHE ALA THR TYR HIS
SEQRES 17 G 1340 THR PRO ALA THR ASP CYS SER ASP GLY ASN TYR ASN ARG
SEQRES 18 G 1340 ASN ALA SER LEU ASN SER PHE LYS GLU TYR PHE ASN LEU
SEQRES 19 G 1340 ARG ASN CYS THR PHE MET TYR THR TYR ASN ILE THR GLU
SEQRES 20 G 1340 ASP GLU ILE LEU GLU TRP PHE GLY ILE THR GLN THR ALA
SEQRES 21 G 1340 GLN GLY VAL HIS LEU PHE SER SER ARG TYR VAL ASP LEU
SEQRES 22 G 1340 TYR GLY GLY ASN MET PHE GLN PHE ALA THR LEU PRO VAL
SEQRES 23 G 1340 TYR ASP THR ILE LYS TYR TYR SER ILE ILE PRO HIS SER
SEQRES 24 G 1340 ILE ARG SER ILE GLN SER ASP ARG LYS ALA TRP ALA ALA
SEQRES 25 G 1340 PHE TYR VAL TYR LYS LEU GLN PRO LEU THR PHE LEU LEU
SEQRES 26 G 1340 ASP PHE SER VAL ASP GLY TYR ILE ARG ARG ALA ILE ASP
SEQRES 27 G 1340 CYS GLY PHE ASN ASP LEU SER GLN LEU HIS CYS SER TYR
SEQRES 28 G 1340 GLU SER PHE ASP VAL GLU SER GLY VAL TYR SER VAL SER
SEQRES 29 G 1340 SER PHE GLU ALA LYS PRO SER GLY SER VAL VAL GLU GLN
SEQRES 30 G 1340 ALA GLU GLY VAL GLU CYS ASP PHE SER PRO LEU LEU SER
SEQRES 31 G 1340 GLY THR PRO PRO GLN VAL TYR ASN PHE LYS ARG LEU VAL
SEQRES 32 G 1340 PHE THR ASN CYS ASN TYR ASN LEU THR LYS LEU LEU SER
SEQRES 33 G 1340 LEU PHE SER VAL ASN ASP PHE THR CYS SER GLN ILE SER
SEQRES 34 G 1340 PRO ALA ALA ILE ALA SER ASN CYS TYR SER SER LEU ILE
SEQRES 35 G 1340 LEU ASP TYR PHE SER TYR PRO LEU SER MET LYS SER ASP
SEQRES 36 G 1340 LEU SER VAL SER SER ALA GLY PRO ILE SER GLN PHE ASN
SEQRES 37 G 1340 TYR LYS GLN SER PHE SER ASN PRO THR CYS LEU ILE LEU
SEQRES 38 G 1340 ALA THR VAL PRO HIS ASN LEU THR THR ILE THR LYS PRO
SEQRES 39 G 1340 LEU LYS TYR SER TYR ILE ASN LYS CYS SER ARG PHE LEU
SEQRES 40 G 1340 SER ASP ASP ARG THR GLU VAL PRO GLN LEU VAL ASN ALA
SEQRES 41 G 1340 ASN GLN TYR SER PRO CYS VAL SER ILE VAL PRO SER THR
SEQRES 42 G 1340 VAL TRP GLU ASP GLY ASP TYR TYR ARG LYS GLN LEU SER
SEQRES 43 G 1340 PRO LEU GLU GLY GLY GLY TRP LEU VAL ALA SER GLY SER
SEQRES 44 G 1340 THR VAL ALA MET THR GLU GLN LEU GLN MET GLY PHE GLY
SEQRES 45 G 1340 ILE THR VAL GLN TYR GLY THR ASP THR ASN SER VAL CYS
SEQRES 46 G 1340 PRO LYS LEU GLU PHE ALA ASN ASP THR LYS ILE ALA SER
SEQRES 47 G 1340 GLN LEU GLY ASN CYS VAL GLU TYR SER LEU TYR GLY VAL
SEQRES 48 G 1340 SER GLY ARG GLY VAL PHE GLN ASN CYS THR ALA VAL GLY
SEQRES 49 G 1340 VAL ARG GLN GLN ARG PHE VAL TYR ASP ALA TYR GLN ASN
SEQRES 50 G 1340 LEU VAL GLY TYR TYR SER ASP ASP GLY ASN TYR TYR CYS
SEQRES 51 G 1340 LEU ARG ALA CYS VAL SER VAL PRO VAL SER VAL ILE TYR
SEQRES 52 G 1340 ASP LYS GLU THR LYS THR HIS ALA THR LEU PHE GLY SER
SEQRES 53 G 1340 VAL ALA CYS GLU HIS ILE SER SER THR MET SER GLN TYR
SEQRES 54 G 1340 SER ARG SER THR ARG SER MET LEU LYS ARG ARG ASP SER
SEQRES 55 G 1340 THR TYR GLY PRO LEU GLN THR PRO VAL GLY CYS VAL LEU
SEQRES 56 G 1340 GLY LEU VAL ASN SER SER LEU PHE VAL GLU ASP CYS LYS
SEQRES 57 G 1340 LEU PRO LEU GLY GLN SER LEU CYS ALA LEU PRO ASP THR
SEQRES 58 G 1340 PRO SER THR LEU THR PRO ARG SER VAL ARG SER VAL PRO
SEQRES 59 G 1340 GLY GLU MET ARG LEU ALA SER ILE ALA PHE ASN HIS PRO
SEQRES 60 G 1340 ILE GLN VAL ASP GLN LEU ASN SER SER TYR PHE LYS LEU
SEQRES 61 G 1340 SER ILE PRO THR ASN PHE SER PHE GLY VAL THR GLN GLU
SEQRES 62 G 1340 TYR ILE GLN THR THR ILE GLN LYS VAL THR VAL ASP CYS
SEQRES 63 G 1340 LYS GLN TYR VAL CYS ASN GLY PHE GLN LYS CYS GLU GLN
SEQRES 64 G 1340 LEU LEU ARG GLU TYR GLY GLN PHE CYS SER LYS ILE ASN
SEQRES 65 G 1340 GLN ALA LEU HIS GLY ALA ASN LEU ARG GLN ASP ASP SER
SEQRES 66 G 1340 VAL ARG ASN LEU PHE ALA SER VAL LYS SER SER GLN SER
SEQRES 67 G 1340 SER PRO ILE ILE PRO GLY PHE GLY GLY ASP PHE ASN LEU
SEQRES 68 G 1340 THR LEU LEU GLU PRO VAL SER ILE SER THR GLY SER ARG
SEQRES 69 G 1340 SER ALA ARG SER ALA ILE GLU ASP LEU LEU PHE ASP LYS
SEQRES 70 G 1340 VAL THR ILE ALA ASP PRO GLY TYR MET GLN GLY TYR ASP
SEQRES 71 G 1340 ASP CYS MET GLN GLN GLY PRO ALA SER ALA ARG ASP LEU
SEQRES 72 G 1340 ILE CYS ALA GLN TYR VAL ALA GLY TYR LYS VAL LEU PRO
SEQRES 73 G 1340 PRO LEU MET ASP VAL ASN MET GLU ALA ALA TYR THR SER
SEQRES 74 G 1340 SER LEU LEU GLY SER ILE ALA GLY VAL GLY TRP THR ALA
SEQRES 75 G 1340 GLY LEU SER SER PHE ALA ALA ILE PRO PHE ALA GLN SER
SEQRES 76 G 1340 ILE PHE TYR ARG LEU ASN GLY VAL GLY ILE THR GLN GLN
SEQRES 77 G 1340 VAL LEU SER GLU ASN GLN LYS LEU ILE ALA ASN LYS PHE
SEQRES 78 G 1340 ASN GLN ALA LEU GLY ALA MET GLN THR GLY PHE THR THR
SEQRES 79 G 1340 THR ASN GLU ALA PHE HIS LYS VAL GLN ASP ALA VAL ASN
SEQRES 80 G 1340 ASN ASN ALA GLN ALA LEU SER LYS LEU ALA SER GLU LEU
SEQRES 81 G 1340 SER ASN THR PHE GLY ALA ILE SER ALA SER ILE GLY ASP
SEQRES 82 G 1340 ILE ILE GLN ARG LEU ASP VAL LEU GLU GLN ASP ALA GLN
SEQRES 83 G 1340 ILE ASP ARG LEU ILE ASN GLY ARG LEU THR THR LEU ASN
SEQRES 84 G 1340 ALA PHE VAL ALA GLN GLN LEU VAL ARG SER GLU SER ALA
SEQRES 85 G 1340 ALA LEU SER ALA GLN LEU ALA LYS ASP LYS VAL ASN GLU
SEQRES 86 G 1340 CYS VAL LYS ALA GLN SER LYS ARG SER GLY PHE CYS GLY
SEQRES 87 G 1340 GLN GLY THR HIS ILE VAL SER PHE VAL VAL ASN ALA PRO
SEQRES 88 G 1340 ASN GLY LEU TYR PHE MET HIS VAL GLY TYR TYR PRO SER
SEQRES 89 G 1340 ASN HIS ILE GLU VAL VAL SER ALA TYR GLY LEU CYS ASP
SEQRES 90 G 1340 ALA ALA ASN PRO THR ASN CYS ILE ALA PRO VAL ASN GLY
SEQRES 91 G 1340 TYR PHE ILE LYS THR ASN ASN THR ARG ILE VAL ASP GLU
SEQRES 92 G 1340 TRP SER TYR THR GLY SER SER PHE TYR ALA PRO GLU PRO
SEQRES 93 G 1340 ILE THR SER LEU ASN THR LYS TYR VAL ALA PRO GLN VAL
SEQRES 94 G 1340 THR TYR GLN ASN ILE SER THR ASN LEU PRO PRO PRO LEU
SEQRES 95 G 1340 LEU GLY ASN SER THR GLY ILE ASP PHE GLN ASP GLU LEU
SEQRES 96 G 1340 ASP GLU PHE PHE LYS ASN VAL SER THR SER ILE PRO ASN
SEQRES 97 G 1340 PHE GLY SER LEU THR GLN ILE ASN THR THR LEU LEU ASP
SEQRES 98 G 1340 LEU THR TYR GLU MET LEU SER LEU GLN GLN VAL VAL LYS
SEQRES 99 G 1340 ALA LEU ASN GLU SER TYR ILE ASP LEU LYS GLU LEU GLY
SEQRES 100 G 1340 ASN TYR THR TYR GLY SER GLY TYR ILE PRO GLU ALA PRO
SEQRES 101 G 1340 ARG ASP GLY GLN ALA TYR VAL ARG LYS ASP GLY GLU TRP
SEQRES 102 G 1340 VAL LEU LEU SER THR PHE LEU GLY ARG SER LEU GLU VAL
SEQRES 103 G 1340 LEU PHE GLN GLY PRO GLY HIS HIS HIS HIS HIS HIS HIS
SEQRES 104 G 1340 HIS
SEQRES 1 C 1340 MET ILE HIS SER VAL PHE LEU LEU MET PHE LEU LEU THR
SEQRES 2 C 1340 PRO THR GLU SER TYR VAL ASP VAL GLY PRO ASP SER VAL
SEQRES 3 C 1340 LYS SER ALA CYS ILE GLU VAL ASP ILE GLN GLN THR PHE
SEQRES 4 C 1340 PHE ASP LYS THR TRP PRO ARG PRO ILE ASP VAL SER LYS
SEQRES 5 C 1340 ALA ASP GLY ILE ILE TYR PRO GLN GLY ARG THR TYR SER
SEQRES 6 C 1340 ASN ILE THR ILE THR TYR GLN GLY LEU PHE PRO TYR GLN
SEQRES 7 C 1340 GLY ASP HIS GLY ASP MET TYR VAL TYR SER ALA GLY HIS
SEQRES 8 C 1340 ALA THR GLY THR THR PRO GLN LYS LEU PHE VAL ALA ASN
SEQRES 9 C 1340 TYR SER GLN ASP VAL LYS GLN PHE ALA ASN GLY PHE VAL
SEQRES 10 C 1340 VAL ARG ILE GLY ALA ALA ALA ASN SER THR GLY THR VAL
SEQRES 11 C 1340 ILE ILE SER PRO SER THR SER ALA THR ILE ARG LYS ILE
SEQRES 12 C 1340 TYR PRO ALA PHE MET LEU GLY SER SER VAL GLY ASN PHE
SEQRES 13 C 1340 SER ASP GLY LYS MET GLY ARG PHE PHE ASN HIS THR LEU
SEQRES 14 C 1340 VAL LEU LEU PRO ASP GLY CYS GLY THR LEU LEU ARG ALA
SEQRES 15 C 1340 PHE TYR CYS ILE LEU GLU PRO ARG SER GLY ASN HIS CYS
SEQRES 16 C 1340 PRO ALA GLY ASN SER TYR THR SER PHE ALA THR TYR HIS
SEQRES 17 C 1340 THR PRO ALA THR ASP CYS SER ASP GLY ASN TYR ASN ARG
SEQRES 18 C 1340 ASN ALA SER LEU ASN SER PHE LYS GLU TYR PHE ASN LEU
SEQRES 19 C 1340 ARG ASN CYS THR PHE MET TYR THR TYR ASN ILE THR GLU
SEQRES 20 C 1340 ASP GLU ILE LEU GLU TRP PHE GLY ILE THR GLN THR ALA
SEQRES 21 C 1340 GLN GLY VAL HIS LEU PHE SER SER ARG TYR VAL ASP LEU
SEQRES 22 C 1340 TYR GLY GLY ASN MET PHE GLN PHE ALA THR LEU PRO VAL
SEQRES 23 C 1340 TYR ASP THR ILE LYS TYR TYR SER ILE ILE PRO HIS SER
SEQRES 24 C 1340 ILE ARG SER ILE GLN SER ASP ARG LYS ALA TRP ALA ALA
SEQRES 25 C 1340 PHE TYR VAL TYR LYS LEU GLN PRO LEU THR PHE LEU LEU
SEQRES 26 C 1340 ASP PHE SER VAL ASP GLY TYR ILE ARG ARG ALA ILE ASP
SEQRES 27 C 1340 CYS GLY PHE ASN ASP LEU SER GLN LEU HIS CYS SER TYR
SEQRES 28 C 1340 GLU SER PHE ASP VAL GLU SER GLY VAL TYR SER VAL SER
SEQRES 29 C 1340 SER PHE GLU ALA LYS PRO SER GLY SER VAL VAL GLU GLN
SEQRES 30 C 1340 ALA GLU GLY VAL GLU CYS ASP PHE SER PRO LEU LEU SER
SEQRES 31 C 1340 GLY THR PRO PRO GLN VAL TYR ASN PHE LYS ARG LEU VAL
SEQRES 32 C 1340 PHE THR ASN CYS ASN TYR ASN LEU THR LYS LEU LEU SER
SEQRES 33 C 1340 LEU PHE SER VAL ASN ASP PHE THR CYS SER GLN ILE SER
SEQRES 34 C 1340 PRO ALA ALA ILE ALA SER ASN CYS TYR SER SER LEU ILE
SEQRES 35 C 1340 LEU ASP TYR PHE SER TYR PRO LEU SER MET LYS SER ASP
SEQRES 36 C 1340 LEU SER VAL SER SER ALA GLY PRO ILE SER GLN PHE ASN
SEQRES 37 C 1340 TYR LYS GLN SER PHE SER ASN PRO THR CYS LEU ILE LEU
SEQRES 38 C 1340 ALA THR VAL PRO HIS ASN LEU THR THR ILE THR LYS PRO
SEQRES 39 C 1340 LEU LYS TYR SER TYR ILE ASN LYS CYS SER ARG PHE LEU
SEQRES 40 C 1340 SER ASP ASP ARG THR GLU VAL PRO GLN LEU VAL ASN ALA
SEQRES 41 C 1340 ASN GLN TYR SER PRO CYS VAL SER ILE VAL PRO SER THR
SEQRES 42 C 1340 VAL TRP GLU ASP GLY ASP TYR TYR ARG LYS GLN LEU SER
SEQRES 43 C 1340 PRO LEU GLU GLY GLY GLY TRP LEU VAL ALA SER GLY SER
SEQRES 44 C 1340 THR VAL ALA MET THR GLU GLN LEU GLN MET GLY PHE GLY
SEQRES 45 C 1340 ILE THR VAL GLN TYR GLY THR ASP THR ASN SER VAL CYS
SEQRES 46 C 1340 PRO LYS LEU GLU PHE ALA ASN ASP THR LYS ILE ALA SER
SEQRES 47 C 1340 GLN LEU GLY ASN CYS VAL GLU TYR SER LEU TYR GLY VAL
SEQRES 48 C 1340 SER GLY ARG GLY VAL PHE GLN ASN CYS THR ALA VAL GLY
SEQRES 49 C 1340 VAL ARG GLN GLN ARG PHE VAL TYR ASP ALA TYR GLN ASN
SEQRES 50 C 1340 LEU VAL GLY TYR TYR SER ASP ASP GLY ASN TYR TYR CYS
SEQRES 51 C 1340 LEU ARG ALA CYS VAL SER VAL PRO VAL SER VAL ILE TYR
SEQRES 52 C 1340 ASP LYS GLU THR LYS THR HIS ALA THR LEU PHE GLY SER
SEQRES 53 C 1340 VAL ALA CYS GLU HIS ILE SER SER THR MET SER GLN TYR
SEQRES 54 C 1340 SER ARG SER THR ARG SER MET LEU LYS ARG ARG ASP SER
SEQRES 55 C 1340 THR TYR GLY PRO LEU GLN THR PRO VAL GLY CYS VAL LEU
SEQRES 56 C 1340 GLY LEU VAL ASN SER SER LEU PHE VAL GLU ASP CYS LYS
SEQRES 57 C 1340 LEU PRO LEU GLY GLN SER LEU CYS ALA LEU PRO ASP THR
SEQRES 58 C 1340 PRO SER THR LEU THR PRO ARG SER VAL ARG SER VAL PRO
SEQRES 59 C 1340 GLY GLU MET ARG LEU ALA SER ILE ALA PHE ASN HIS PRO
SEQRES 60 C 1340 ILE GLN VAL ASP GLN LEU ASN SER SER TYR PHE LYS LEU
SEQRES 61 C 1340 SER ILE PRO THR ASN PHE SER PHE GLY VAL THR GLN GLU
SEQRES 62 C 1340 TYR ILE GLN THR THR ILE GLN LYS VAL THR VAL ASP CYS
SEQRES 63 C 1340 LYS GLN TYR VAL CYS ASN GLY PHE GLN LYS CYS GLU GLN
SEQRES 64 C 1340 LEU LEU ARG GLU TYR GLY GLN PHE CYS SER LYS ILE ASN
SEQRES 65 C 1340 GLN ALA LEU HIS GLY ALA ASN LEU ARG GLN ASP ASP SER
SEQRES 66 C 1340 VAL ARG ASN LEU PHE ALA SER VAL LYS SER SER GLN SER
SEQRES 67 C 1340 SER PRO ILE ILE PRO GLY PHE GLY GLY ASP PHE ASN LEU
SEQRES 68 C 1340 THR LEU LEU GLU PRO VAL SER ILE SER THR GLY SER ARG
SEQRES 69 C 1340 SER ALA ARG SER ALA ILE GLU ASP LEU LEU PHE ASP LYS
SEQRES 70 C 1340 VAL THR ILE ALA ASP PRO GLY TYR MET GLN GLY TYR ASP
SEQRES 71 C 1340 ASP CYS MET GLN GLN GLY PRO ALA SER ALA ARG ASP LEU
SEQRES 72 C 1340 ILE CYS ALA GLN TYR VAL ALA GLY TYR LYS VAL LEU PRO
SEQRES 73 C 1340 PRO LEU MET ASP VAL ASN MET GLU ALA ALA TYR THR SER
SEQRES 74 C 1340 SER LEU LEU GLY SER ILE ALA GLY VAL GLY TRP THR ALA
SEQRES 75 C 1340 GLY LEU SER SER PHE ALA ALA ILE PRO PHE ALA GLN SER
SEQRES 76 C 1340 ILE PHE TYR ARG LEU ASN GLY VAL GLY ILE THR GLN GLN
SEQRES 77 C 1340 VAL LEU SER GLU ASN GLN LYS LEU ILE ALA ASN LYS PHE
SEQRES 78 C 1340 ASN GLN ALA LEU GLY ALA MET GLN THR GLY PHE THR THR
SEQRES 79 C 1340 THR ASN GLU ALA PHE HIS LYS VAL GLN ASP ALA VAL ASN
SEQRES 80 C 1340 ASN ASN ALA GLN ALA LEU SER LYS LEU ALA SER GLU LEU
SEQRES 81 C 1340 SER ASN THR PHE GLY ALA ILE SER ALA SER ILE GLY ASP
SEQRES 82 C 1340 ILE ILE GLN ARG LEU ASP VAL LEU GLU GLN ASP ALA GLN
SEQRES 83 C 1340 ILE ASP ARG LEU ILE ASN GLY ARG LEU THR THR LEU ASN
SEQRES 84 C 1340 ALA PHE VAL ALA GLN GLN LEU VAL ARG SER GLU SER ALA
SEQRES 85 C 1340 ALA LEU SER ALA GLN LEU ALA LYS ASP LYS VAL ASN GLU
SEQRES 86 C 1340 CYS VAL LYS ALA GLN SER LYS ARG SER GLY PHE CYS GLY
SEQRES 87 C 1340 GLN GLY THR HIS ILE VAL SER PHE VAL VAL ASN ALA PRO
SEQRES 88 C 1340 ASN GLY LEU TYR PHE MET HIS VAL GLY TYR TYR PRO SER
SEQRES 89 C 1340 ASN HIS ILE GLU VAL VAL SER ALA TYR GLY LEU CYS ASP
SEQRES 90 C 1340 ALA ALA ASN PRO THR ASN CYS ILE ALA PRO VAL ASN GLY
SEQRES 91 C 1340 TYR PHE ILE LYS THR ASN ASN THR ARG ILE VAL ASP GLU
SEQRES 92 C 1340 TRP SER TYR THR GLY SER SER PHE TYR ALA PRO GLU PRO
SEQRES 93 C 1340 ILE THR SER LEU ASN THR LYS TYR VAL ALA PRO GLN VAL
SEQRES 94 C 1340 THR TYR GLN ASN ILE SER THR ASN LEU PRO PRO PRO LEU
SEQRES 95 C 1340 LEU GLY ASN SER THR GLY ILE ASP PHE GLN ASP GLU LEU
SEQRES 96 C 1340 ASP GLU PHE PHE LYS ASN VAL SER THR SER ILE PRO ASN
SEQRES 97 C 1340 PHE GLY SER LEU THR GLN ILE ASN THR THR LEU LEU ASP
SEQRES 98 C 1340 LEU THR TYR GLU MET LEU SER LEU GLN GLN VAL VAL LYS
SEQRES 99 C 1340 ALA LEU ASN GLU SER TYR ILE ASP LEU LYS GLU LEU GLY
SEQRES 100 C 1340 ASN TYR THR TYR GLY SER GLY TYR ILE PRO GLU ALA PRO
SEQRES 101 C 1340 ARG ASP GLY GLN ALA TYR VAL ARG LYS ASP GLY GLU TRP
SEQRES 102 C 1340 VAL LEU LEU SER THR PHE LEU GLY ARG SER LEU GLU VAL
SEQRES 103 C 1340 LEU PHE GLN GLY PRO GLY HIS HIS HIS HIS HIS HIS HIS
SEQRES 104 C 1340 HIS
HELIX 1 AA1 THR A 44 LYS A 50 1 7
HELIX 2 AA2 GLU A 91 PHE A 95 5 5
HELIX 3 AA3 ASP A 200 VAL A 207 1 8
HELIX 4 AA4 GLU A 421 MET A 425 5 5
HELIX 5 AA5 ASN A 497 ASN A 506 1 10
HELIX 6 AA6 ASN A 562 THR A 570 1 9
HELIX 7 AA7 GLY A 587 HIS A 592 1 6
HELIX 8 AA8 ALA A 593 ASN A 595 5 3
HELIX 9 AA9 THR A 600 LYS A 615 1 16
HELIX 10 AB1 TYR A 631 GLY A 641 1 11
HELIX 11 AB2 ASP A 663 GLY A 672 1 10
HELIX 12 AB3 ASN A 679 SER A 686 1 8
HELIX 13 AB4 VAL A 688 ALA A 692 5 5
HELIX 14 AB5 GLU A 693 VAL A 698 5 6
HELIX 15 AB6 PHE A 713 GLY A 727 1 15
HELIX 16 AB7 SER A 744 SER A 764 1 21
HELIX 17 AB8 THR B 44 LYS B 50 1 7
HELIX 18 AB9 ASP B 200 VAL B 207 1 8
HELIX 19 AC1 ASP B 274 LEU B 276 5 3
HELIX 20 AC2 PRO B 290 LEU B 294 5 5
HELIX 21 AC3 GLU B 421 MET B 425 5 5
HELIX 22 AC4 ASN B 497 ASN B 506 1 10
HELIX 23 AC5 ASN B 562 THR B 570 1 9
HELIX 24 AC6 GLY B 587 HIS B 592 1 6
HELIX 25 AC7 ALA B 593 ASN B 595 5 3
HELIX 26 AC8 THR B 600 GLY B 617 1 18
HELIX 27 AC9 TYR B 631 GLY B 641 1 11
HELIX 28 AD1 ASP B 663 GLY B 672 1 10
HELIX 29 AD2 ASN B 679 SER B 686 1 8
HELIX 30 AD3 VAL B 688 VAL B 698 5 11
HELIX 31 AD4 PHE B 713 GLY B 727 1 15
HELIX 32 AD5 SER B 744 PHE B 763 1 20
HELIX 33 AD6 ASP F 49 ALA F 53 5 5
HELIX 34 AD7 ASN F 222 TYR F 231 1 10
HELIX 35 AD8 SER F 345 GLU F 352 1 8
HELIX 36 AD9 PHE F 385 SER F 390 1 6
HELIX 37 AE1 ASN F 410 PHE F 418 1 9
HELIX 38 AE2 ALA F 431 SER F 435 5 5
HELIX 39 AE3 SER F 607 VAL F 611 5 5
HELIX 40 AE4 ALA F 678 ILE F 682 5 5
HELIX 41 AE5 THR F 693 ARG F 699 1 7
HELIX 42 AE6 ASP F 805 CYS F 811 1 7
HELIX 43 AE7 PHE F 814 ARG F 822 1 9
HELIX 44 AE8 GLN F 826 SER F 852 1 27
HELIX 45 AE9 SER F 878 ARG F 884 5 7
HELIX 46 AF1 SER F 888 VAL F 898 1 11
HELIX 47 AF2 GLN F 907 MET F 913 1 7
HELIX 48 AF3 ALA F 926 GLY F 931 1 6
HELIX 49 AF4 ASP F 940 SER F 954 1 15
HELIX 50 AF5 PRO F 971 GLY F 982 1 12
HELIX 51 AF6 THR F 986 ASN F 993 1 8
HELIX 52 AF7 ASN F 993 GLY F 1006 1 14
HELIX 53 AF8 ALA F 1007 GLN F 1009 5 3
HELIX 54 AF9 ASN F 1016 SER F 1038 1 23
HELIX 55 AG1 SER F 1050 GLN F 1056 1 7
HELIX 56 AG2 ASP F 1059 VAL F 1107 1 49
HELIX 57 AG3 ASN F 1177 ASP F 1182 1 6
HELIX 58 AG4 ASP G 49 ALA G 53 5 5
HELIX 59 AG5 ASN G 222 TYR G 231 1 10
HELIX 60 AG6 SER G 345 GLU G 352 1 8
HELIX 61 AG7 SER G 386 SER G 390 5 5
HELIX 62 AG8 GLN G 395 PHE G 399 5 5
HELIX 63 AG9 ASN G 410 LEU G 415 1 6
HELIX 64 AH1 PRO G 449 LEU G 456 5 8
HELIX 65 AH2 PRO G 463 ASN G 468 1 6
HELIX 66 AH3 SER G 524 ILE G 529 5 6
HELIX 67 AH4 SER G 546 GLY G 550 5 5
HELIX 68 AH5 LYS G 595 GLN G 599 5 5
HELIX 69 AH6 ALA G 678 ILE G 682 5 5
HELIX 70 AH7 THR G 693 LYS G 698 1 6
HELIX 71 AH8 ASP G 805 CYS G 811 1 7
HELIX 72 AH9 PHE G 814 ARG G 822 1 9
HELIX 73 AI1 GLN G 826 SER G 852 1 27
HELIX 74 AI2 SER G 888 ASP G 896 1 9
HELIX 75 AI3 GLN G 907 CYS G 912 1 6
HELIX 76 AI4 ALA G 926 GLY G 931 1 6
HELIX 77 AI5 ASP G 940 SER G 954 1 15
HELIX 78 AI6 PRO G 971 GLY G 982 1 12
HELIX 79 AI7 THR G 986 ASN G 993 1 8
HELIX 80 AI8 ASN G 993 GLY G 1006 1 14
HELIX 81 AI9 ALA G 1007 GLN G 1009 5 3
HELIX 82 AJ1 ASN G 1016 SER G 1038 1 23
HELIX 83 AJ2 SER G 1050 ILE G 1055 1 6
HELIX 84 AJ3 ASP G 1059 ASP G 1064 1 6
HELIX 85 AJ4 GLN G 1066 CYS G 1106 1 41
HELIX 86 AJ5 ASN G 1177 ASP G 1182 1 6
HELIX 87 AJ6 ASP C 49 ALA C 53 5 5
HELIX 88 AJ7 ASN C 222 TYR C 231 1 10
HELIX 89 AJ8 SER C 345 GLU C 352 1 8
HELIX 90 AJ9 PHE C 385 SER C 390 1 6
HELIX 91 AK1 ASN C 410 LEU C 417 1 8
HELIX 92 AK2 ALA C 432 ASN C 436 5 5
HELIX 93 AK3 ALA C 678 ILE C 682 5 5
HELIX 94 AK4 THR C 693 ARG C 699 1 7
HELIX 95 AK5 ASP C 805 CYS C 811 1 7
HELIX 96 AK6 PHE C 814 ARG C 822 1 9
HELIX 97 AK7 GLN C 826 SER C 852 1 27
HELIX 98 AK8 ILE C 879 ARG C 884 5 6
HELIX 99 AK9 SER C 888 VAL C 898 1 11
HELIX 100 AL1 GLN C 907 MET C 913 1 7
HELIX 101 AL2 ALA C 926 GLY C 931 1 6
HELIX 102 AL3 ASP C 940 SER C 954 1 15
HELIX 103 AL4 PRO C 971 GLY C 982 1 12
HELIX 104 AL5 THR C 986 ASN C 993 1 8
HELIX 105 AL6 ASN C 993 GLY C 1006 1 14
HELIX 106 AL7 ALA C 1007 GLN C 1009 5 3
HELIX 107 AL8 ASN C 1016 SER C 1038 1 23
HELIX 108 AL9 SER C 1050 LEU C 1058 1 9
HELIX 109 AM1 ASP C 1059 VAL C 1107 1 49
HELIX 110 AM2 ASN C 1177 ASP C 1182 1 6
SHEET 1 AA1 4 LEU A 60 TRP A 62 0
SHEET 2 AA1 4 GLU A 67 GLN A 72 -1 O LEU A 69 N ARG A 61
SHEET 3 AA1 4 ASN A 75 ASN A 80 -1 O ASN A 75 N GLN A 72
SHEET 4 AA1 4 SER A 86 LEU A 90 -1 O LEU A 90 N ILE A 76
SHEET 1 AA2 4 ILE A 102 ILE A 107 0
SHEET 2 AA2 4 PHE A 113 LYS A 122 -1 O GLU A 117 N ASN A 103
SHEET 3 AA2 4 TYR A 128 ASP A 136 -1 O THR A 129 N VAL A 121
SHEET 4 AA2 4 LEU A 142 ILE A 143 -1 O ILE A 143 N ILE A 134
SHEET 1 AA3 4 TRP A 154 TRP A 157 0
SHEET 2 AA3 4 LEU A 164 VAL A 167 -1 O VAL A 167 N TRP A 154
SHEET 3 AA3 4 ILE A 172 LYS A 175 -1 O LYS A 175 N LEU A 164
SHEET 4 AA3 4 TYR A 183 ARG A 184 -1 O TYR A 183 N VAL A 174
SHEET 1 AA4 3 ILE A 194 ASN A 196 0
SHEET 2 AA4 3 PHE A 222 ASN A 229 -1 O PHE A 228 N TYR A 195
SHEET 3 AA4 3 TRP A 215 TRP A 216 -1 N TRP A 215 O ALA A 224
SHEET 1 AA5 4 ILE A 194 ASN A 196 0
SHEET 2 AA5 4 PHE A 222 ASN A 229 -1 O PHE A 228 N TYR A 195
SHEET 3 AA5 4 THR A 265 ASN A 272 -1 O LYS A 267 N GLN A 227
SHEET 4 AA5 4 ILE A 285 GLN A 286 -1 O ILE A 285 N VAL A 270
SHEET 1 AA6 2 LEU A 235 PHE A 240 0
SHEET 2 AA6 2 LYS A 250 PRO A 255 -1 O VAL A 254 N ILE A 236
SHEET 1 AA7 4 HIS A 298 THR A 307 0
SHEET 2 AA7 4 ARG A 310 ARG A 317 -1 O LEU A 316 N TYR A 299
SHEET 3 AA7 4 TYR A 322 ASP A 331 -1 O ASP A 326 N LEU A 313
SHEET 4 AA7 4 ARG A 336 CYS A 339 -1 O ASN A 338 N ASP A 329
SHEET 1 AA8 4 HIS A 298 THR A 307 0
SHEET 2 AA8 4 ARG A 310 ARG A 317 -1 O LEU A 316 N TYR A 299
SHEET 3 AA8 4 TYR A 322 ASP A 331 -1 O ASP A 326 N LEU A 313
SHEET 4 AA8 4 HIS A 345 MET A 348 -1 O HIS A 345 N MET A 325
SHEET 1 AA9 4 HIS A 363 PHE A 364 0
SHEET 2 AA9 4 PHE A 371 SER A 376 -1 O TYR A 372 N HIS A 363
SHEET 3 AA9 4 ARG A 382 TYR A 386 -1 O HIS A 383 N ILE A 375
SHEET 4 AA9 4 THR A 395 PHE A 396 -1 O THR A 395 N TYR A 386
SHEET 1 AB1 4 VAL A 404 LEU A 410 0
SHEET 2 AB1 4 TYR A 414 SER A 419 -1 O ILE A 418 N ILE A 405
SHEET 3 AB1 4 ASN A 430 GLN A 435 -1 O TYR A 432 N TYR A 417
SHEET 4 AB1 4 VAL A 442 CYS A 444 -1 O THR A 443 N LYS A 433
SHEET 1 AB2 4 VAL A 459 PHE A 461 0
SHEET 2 AB2 4 TYR A 467 ARG A 471 -1 O GLN A 469 N SER A 460
SHEET 3 AB2 4 TYR A 480 SER A 484 -1 O HIS A 483 N TYR A 468
SHEET 4 AB2 4 GLY A 490 GLU A 495 -1 O GLU A 495 N TYR A 480
SHEET 1 AB3 5 SER A 511 ILE A 518 0
SHEET 2 AB3 5 LYS A 523 LEU A 530 -1 O TYR A 526 N ASP A 515
SHEET 3 AB3 5 ILE A 574 PHE A 578 -1 O VAL A 575 N ILE A 529
SHEET 4 AB3 5 TYR A 540 ASP A 545 1 N LEU A 543 O ILE A 574
SHEET 5 AB3 5 VAL A 619 TRP A 627 1 O ALA A 625 N LEU A 544
SHEET 1 AB4 3 CYS A 649 VAL A 653 0
SHEET 2 AB4 3 GLU A 699 GLY A 705 1 O ILE A 703 N ALA A 652
SHEET 3 AB4 3 GLN A 731 TYR A 735 1 O GLN A 731 N LEU A 702
SHEET 1 AB5 4 ARG B 61 TRP B 62 0
SHEET 2 AB5 4 GLU B 67 GLN B 72 -1 O LEU B 69 N ARG B 61
SHEET 3 AB5 4 ASN B 75 ASN B 80 -1 O ASN B 75 N GLN B 72
SHEET 4 AB5 4 SER B 86 LEU B 90 -1 O LEU B 90 N ILE B 76
SHEET 1 AB6 4 ASP B 104 ILE B 107 0
SHEET 2 AB6 4 PHE B 113 LYS B 122 -1 O LEU B 115 N SER B 106
SHEET 3 AB6 4 TYR B 128 ASP B 136 -1 O THR B 129 N VAL B 121
SHEET 4 AB6 4 GLN B 141 LEU B 142 -1 O GLN B 141 N ASP B 136
SHEET 1 AB7 4 TRP B 154 TRP B 157 0
SHEET 2 AB7 4 LEU B 164 VAL B 167 -1 O VAL B 167 N TRP B 154
SHEET 3 AB7 4 ILE B 172 LYS B 175 -1 O LYS B 175 N LEU B 164
SHEET 4 AB7 4 TYR B 183 ARG B 184 -1 O TYR B 183 N VAL B 174
SHEET 1 AB8 3 ILE B 194 ASN B 196 0
SHEET 2 AB8 3 PHE B 222 ASN B 229 -1 O PHE B 228 N TYR B 195
SHEET 3 AB8 3 LEU B 214 TRP B 216 -1 N TRP B 215 O ALA B 224
SHEET 1 AB9 4 ILE B 194 ASN B 196 0
SHEET 2 AB9 4 PHE B 222 ASN B 229 -1 O PHE B 228 N TYR B 195
SHEET 3 AB9 4 THR B 265 ASN B 272 -1 O LYS B 267 N GLN B 227
SHEET 4 AB9 4 SER B 284 GLN B 286 -1 O ILE B 285 N VAL B 270
SHEET 1 AC1 2 LEU B 235 PHE B 240 0
SHEET 2 AC1 2 LYS B 250 PRO B 255 -1 O VAL B 254 N ILE B 236
SHEET 1 AC2 4 HIS B 298 THR B 307 0
SHEET 2 AC2 4 ARG B 310 ARG B 317 -1 O LEU B 316 N TYR B 299
SHEET 3 AC2 4 TYR B 322 TYR B 330 -1 O ASP B 326 N LEU B 313
SHEET 4 AC2 4 TRP B 337 CYS B 339 -1 O ASN B 338 N ASP B 329
SHEET 1 AC3 4 HIS B 298 THR B 307 0
SHEET 2 AC3 4 ARG B 310 ARG B 317 -1 O LEU B 316 N TYR B 299
SHEET 3 AC3 4 TYR B 322 TYR B 330 -1 O ASP B 326 N LEU B 313
SHEET 4 AC3 4 HIS B 345 MET B 348 -1 O GLU B 347 N SER B 323
SHEET 1 AC4 3 SER B 370 SER B 376 0
SHEET 2 AC4 3 ARG B 382 GLN B 388 -1 O PHE B 387 N PHE B 371
SHEET 3 AC4 3 LYS B 391 PHE B 396 -1 O THR B 395 N TYR B 386
SHEET 1 AC5 4 VAL B 404 LEU B 410 0
SHEET 2 AC5 4 TYR B 414 SER B 419 -1 O ILE B 418 N ILE B 405
SHEET 3 AC5 4 ASN B 430 GLN B 435 -1 O ILE B 434 N LEU B 415
SHEET 4 AC5 4 VAL B 442 CYS B 444 -1 O THR B 443 N LYS B 433
SHEET 1 AC6 4 TYR B 457 PHE B 461 0
SHEET 2 AC6 4 TYR B 467 CYS B 472 -1 O ARG B 471 N SER B 458
SHEET 3 AC6 4 TYR B 480 SER B 484 -1 O HIS B 483 N TYR B 468
SHEET 4 AC6 4 GLY B 490 GLU B 495 -1 O LEU B 494 N TYR B 480
SHEET 1 AC7 5 SER B 511 ILE B 518 0
SHEET 2 AC7 5 LYS B 523 LEU B 530 -1 O TYR B 526 N ASP B 515
SHEET 3 AC7 5 ILE B 574 PHE B 578 -1 O VAL B 575 N ILE B 529
SHEET 4 AC7 5 TYR B 540 ASP B 545 1 N LEU B 543 O ILE B 574
SHEET 5 AC7 5 VAL B 619 TRP B 627 1 O ALA B 625 N LEU B 544
SHEET 1 AC8 3 CYS B 649 VAL B 653 0
SHEET 2 AC8 3 GLU B 699 ILE B 703 1 O ILE B 703 N ALA B 652
SHEET 3 AC8 3 GLN B 731 MET B 733 1 O GLN B 731 N LEU B 702
SHEET 1 AC9 2 VAL F 33 ILE F 35 0
SHEET 2 AC9 2 LEU F 100 VAL F 102 1 O LEU F 100 N ASP F 34
SHEET 1 AD1 3 THR F 68 PHE F 75 0
SHEET 2 AD1 3 GLN F 319 PHE F 327 -1 O PHE F 323 N TYR F 71
SHEET 3 AD1 3 ILE F 333 ASP F 338 -1 O ILE F 337 N LEU F 324
SHEET 1 AD2 6 ASP F 83 TYR F 85 0
SHEET 2 AD2 6 PHE F 313 LYS F 317 -1 O VAL F 315 N ASP F 83
SHEET 3 AD2 6 PHE F 116 ILE F 120 -1 N VAL F 117 O TYR F 316
SHEET 4 AD2 6 GLU F 252 THR F 259 -1 O PHE F 254 N VAL F 118
SHEET 5 AD2 6 GLY F 262 SER F 267 -1 O PHE F 266 N GLY F 255
SHEET 6 AD2 6 PHE F 279 LEU F 284 -1 O PHE F 279 N SER F 267
SHEET 1 AD3 2 ILE F 140 ARG F 141 0
SHEET 2 AD3 2 ALA F 309 TRP F 310 1 O ALA F 309 N ARG F 141
SHEET 1 AD4 3 LEU F 169 LEU F 171 0
SHEET 2 AD4 3 PHE F 147 GLY F 150 -1 N PHE F 147 O LEU F 171
SHEET 3 AD4 3 TYR F 292 SER F 294 -1 O TYR F 292 N GLY F 150
SHEET 1 AD5 2 VAL F 153 ASN F 155 0
SHEET 2 AD5 2 MET F 161 PHE F 164 -1 O ARG F 163 N GLY F 154
SHEET 1 AD6 2 LEU F 179 ARG F 181 0
SHEET 2 AD6 2 THR F 242 ASN F 244 -1 O TYR F 243 N LEU F 180
SHEET 1 AD7 2 GLU F 188 PRO F 189 0
SHEET 2 AD7 2 PHE F 232 ASN F 233 -1 O ASN F 233 N GLU F 188
SHEET 1 AD8 2 THR F 206 HIS F 208 0
SHEET 2 AD8 2 HIS F 298 ILE F 300 1 O SER F 299 N THR F 206
SHEET 1 AD9 5 GLY F 359 VAL F 363 0
SHEET 2 AD9 5 VAL F 659 TYR F 663 -1 O VAL F 661 N TYR F 361
SHEET 3 AD9 5 THR F 672 LEU F 673 -1 O LEU F 673 N SER F 660
SHEET 4 AD9 5 GLY F 712 LEU F 715 -1 O LEU F 715 N THR F 672
SHEET 5 AD9 5 LEU F 707 THR F 709 -1 N LEU F 707 O VAL F 714
SHEET 1 AE1 3 LYS F 400 PHE F 404 0
SHEET 2 AE1 3 LEU F 441 SER F 447 -1 O LEU F 441 N PHE F 404
SHEET 3 AE1 3 MET F 569 GLY F 570 -1 O GLY F 570 N PHE F 446
SHEET 1 AE2 2 THR F 424 CYS F 425 0
SHEET 2 AE2 2 CYS F 478 LEU F 479 -1 O LEU F 479 N THR F 424
SHEET 1 AE3 3 TYR F 497 ILE F 500 0
SHEET 2 AE3 3 ALA F 556 VAL F 561 -1 O VAL F 561 N TYR F 497
SHEET 3 AE3 3 TYR F 540 TYR F 541 -1 N TYR F 541 O ALA F 556
SHEET 1 AE4 2 SER F 504 PHE F 506 0
SHEET 2 AE4 2 GLU F 513 PRO F 515 -1 O VAL F 514 N ARG F 505
SHEET 1 AE5 2 VAL F 604 GLU F 605 0
SHEET 2 AE5 2 ARG F 614 GLY F 615 -1 O GLY F 615 N VAL F 604
SHEET 1 AE6 3 VAL F 631 TYR F 632 0
SHEET 2 AE6 3 LEU F 638 TYR F 642 -1 O GLY F 640 N VAL F 631
SHEET 3 AE6 3 TYR F 648 TYR F 649 -1 O TYR F 649 N TYR F 641
SHEET 1 AE7 3 LEU F 717 VAL F 724 0
SHEET 2 AE7 3 MET F 757 ILE F 762 1 O SER F 761 N VAL F 724
SHEET 3 AE7 3 LEU F 735 CYS F 736 -1 N CYS F 736 O ALA F 760
SHEET 1 AE8 3 PHE F 788 GLN F 796 0
SHEET 2 AE8 3 GLY F1133 TYR F1141 -1 O PHE F1136 N GLU F 793
SHEET 3 AE8 3 THR F1121 ASN F1129 -1 N VAL F1124 O VAL F1139
SHEET 1 AE9 2 VAL F 802 VAL F 804 0
SHEET 2 AE9 2 TYR F 932 VAL F 934 -1 O LYS F 933 N THR F 803
SHEET 1 AF1 2 LEU F1155 ASP F1157 0
SHEET 2 AF1 2 GLN F1212 ILE F1214 1 O GLN F1212 N CYS F1156
SHEET 1 AF2 3 GLY F1170 LYS F1174 0
SHEET 2 AF2 3 TRP F1184 GLY F1188 -1 O SER F1185 N ILE F1173
SHEET 3 AF2 3 GLU F1195 PRO F1196 -1 O GLU F1195 N TYR F1186
SHEET 1 AF3 2 VAL G 33 ILE G 35 0
SHEET 2 AF3 2 LEU G 100 VAL G 102 1 O VAL G 102 N ASP G 34
SHEET 1 AF4 3 THR G 68 PHE G 75 0
SHEET 2 AF4 3 GLN G 319 PHE G 327 -1 O PHE G 323 N TYR G 71
SHEET 3 AF4 3 ILE G 333 ASP G 338 -1 O ARG G 335 N ASP G 326
SHEET 1 AF5 6 ASP G 83 TYR G 85 0
SHEET 2 AF5 6 PHE G 313 LYS G 317 -1 O VAL G 315 N ASP G 83
SHEET 3 AF5 6 PHE G 116 ARG G 119 -1 N ARG G 119 O TYR G 314
SHEET 4 AF5 6 PHE G 254 THR G 259 -1 O PHE G 254 N VAL G 118
SHEET 5 AF5 6 GLY G 262 SER G 267 -1 O PHE G 266 N GLY G 255
SHEET 6 AF5 6 PHE G 279 LEU G 284 -1 O PHE G 279 N SER G 267
SHEET 1 AF6 2 ILE G 140 ARG G 141 0
SHEET 2 AF6 2 ALA G 309 TRP G 310 1 O ALA G 309 N ARG G 141
SHEET 1 AF7 4 PHE G 147 LEU G 149 0
SHEET 2 AF7 4 THR G 168 LEU G 171 -1 O LEU G 171 N PHE G 147
SHEET 3 AF7 4 PHE G 183 PRO G 189 -1 O CYS G 185 N THR G 168
SHEET 4 AF7 4 PHE G 232 ARG G 235 -1 O ASN G 233 N GLU G 188
SHEET 1 AF8 2 VAL G 153 ASN G 155 0
SHEET 2 AF8 2 MET G 161 PHE G 164 -1 O ARG G 163 N GLY G 154
SHEET 1 AF9 2 LEU G 179 ARG G 181 0
SHEET 2 AF9 2 THR G 242 ASN G 244 -1 O TYR G 243 N LEU G 180
SHEET 1 AG1 2 THR G 206 HIS G 208 0
SHEET 2 AG1 2 HIS G 298 ILE G 300 1 O SER G 299 N THR G 206
SHEET 1 AG2 5 GLY G 359 VAL G 363 0
SHEET 2 AG2 5 VAL G 659 TYR G 663 -1 O VAL G 661 N TYR G 361
SHEET 3 AG2 5 THR G 672 LEU G 673 -1 O LEU G 673 N SER G 660
SHEET 4 AG2 5 GLY G 712 LEU G 715 -1 O LEU G 715 N THR G 672
SHEET 5 AG2 5 LEU G 707 THR G 709 -1 N LEU G 707 O VAL G 714
SHEET 1 AG3 3 SER G 373 GLU G 376 0
SHEET 2 AG3 3 VAL G 604 LEU G 608 1 O SER G 607 N GLU G 376
SHEET 3 AG3 3 VAL G 611 GLY G 615 -1 O VAL G 611 N LEU G 608
SHEET 1 AG4 5 LEU G 402 PHE G 404 0
SHEET 2 AG4 5 SER G 440 SER G 447 -1 O LEU G 441 N PHE G 404
SHEET 3 AG4 5 GLN G 568 GLN G 576 -1 O GLY G 570 N PHE G 446
SHEET 4 AG4 5 CYS G 478 THR G 483 -1 N ILE G 480 O PHE G 571
SHEET 5 AG4 5 SER G 419 CYS G 425 -1 N THR G 424 O LEU G 479
SHEET 1 AG5 4 GLU G 513 PRO G 515 0
SHEET 2 AG5 4 TYR G 497 PHE G 506 -1 N ARG G 505 O VAL G 514
SHEET 3 AG5 4 TRP G 553 VAL G 561 -1 O VAL G 561 N TYR G 497
SHEET 4 AG5 4 TYR G 540 GLN G 544 -1 N LYS G 543 O LEU G 554
SHEET 1 AG6 2 TYR G 641 TYR G 642 0
SHEET 2 AG6 2 TYR G 648 TYR G 649 -1 O TYR G 649 N TYR G 641
SHEET 1 AG7 3 LEU G 717 VAL G 724 0
SHEET 2 AG7 3 MET G 757 ILE G 762 1 O SER G 761 N VAL G 724
SHEET 3 AG7 3 LEU G 735 CYS G 736 -1 N CYS G 736 O ALA G 760
SHEET 1 AG8 3 PHE G 788 GLN G 796 0
SHEET 2 AG8 3 GLY G1133 TYR G1141 -1 O PHE G1136 N GLU G 793
SHEET 3 AG8 3 THR G1121 ALA G1130 -1 N VAL G1124 O VAL G1139
SHEET 1 AG9 2 VAL G 802 VAL G 804 0
SHEET 2 AG9 2 TYR G 932 VAL G 934 -1 O LYS G 933 N THR G 803
SHEET 1 AH1 2 LEU G1155 ASP G1157 0
SHEET 2 AH1 2 GLN G1212 ILE G1214 1 O GLN G1212 N CYS G1156
SHEET 1 AH2 2 GLY G1170 LYS G1174 0
SHEET 2 AH2 2 TRP G1184 GLY G1188 -1 O SER G1185 N ILE G1173
SHEET 1 AH3 2 VAL C 33 ILE C 35 0
SHEET 2 AH3 2 LEU C 100 VAL C 102 1 O LEU C 100 N ASP C 34
SHEET 1 AH4 3 THR C 68 PHE C 75 0
SHEET 2 AH4 3 GLN C 319 PHE C 327 -1 O PHE C 323 N TYR C 71
SHEET 3 AH4 3 ILE C 333 ASP C 338 -1 O ILE C 337 N LEU C 324
SHEET 1 AH5 6 ASP C 83 TYR C 85 0
SHEET 2 AH5 6 PHE C 313 LYS C 317 -1 O VAL C 315 N ASP C 83
SHEET 3 AH5 6 PHE C 116 ILE C 120 -1 N VAL C 117 O TYR C 316
SHEET 4 AH5 6 GLU C 252 THR C 259 -1 O PHE C 254 N VAL C 118
SHEET 5 AH5 6 GLY C 262 SER C 267 -1 O PHE C 266 N GLY C 255
SHEET 6 AH5 6 PHE C 279 LEU C 284 -1 O PHE C 279 N SER C 267
SHEET 1 AH6 2 ALA C 92 THR C 93 0
SHEET 2 AH6 2 THR C 96 PRO C 97 -1 O THR C 96 N THR C 93
SHEET 1 AH7 2 ILE C 140 ARG C 141 0
SHEET 2 AH7 2 ALA C 309 TRP C 310 1 O ALA C 309 N ARG C 141
SHEET 1 AH8 3 LEU C 169 LEU C 171 0
SHEET 2 AH8 3 PHE C 147 GLY C 150 -1 N PHE C 147 O LEU C 171
SHEET 3 AH8 3 TYR C 292 SER C 294 -1 O TYR C 292 N GLY C 150
SHEET 1 AH9 2 GLY C 154 ASN C 155 0
SHEET 2 AH9 2 MET C 161 ARG C 163 -1 O GLY C 162 N GLY C 154
SHEET 1 AI1 2 LEU C 179 ARG C 181 0
SHEET 2 AI1 2 THR C 242 ASN C 244 -1 O TYR C 243 N LEU C 180
SHEET 1 AI2 2 GLU C 188 PRO C 189 0
SHEET 2 AI2 2 PHE C 232 ASN C 233 -1 O ASN C 233 N GLU C 188
SHEET 1 AI3 2 THR C 206 HIS C 208 0
SHEET 2 AI3 2 HIS C 298 ILE C 300 1 O SER C 299 N THR C 206
SHEET 1 AI4 5 GLY C 359 VAL C 363 0
SHEET 2 AI4 5 VAL C 659 TYR C 663 -1 O VAL C 661 N TYR C 361
SHEET 3 AI4 5 THR C 672 LEU C 673 -1 O LEU C 673 N SER C 660
SHEET 4 AI4 5 GLY C 712 LEU C 715 -1 O LEU C 715 N THR C 672
SHEET 5 AI4 5 LEU C 707 THR C 709 -1 N LEU C 707 O VAL C 714
SHEET 1 AI5 3 LYS C 400 PHE C 404 0
SHEET 2 AI5 3 LEU C 441 TYR C 445 -1 O LEU C 441 N PHE C 404
SHEET 3 AI5 3 PHE C 571 GLY C 572 -1 O GLY C 572 N ASP C 444
SHEET 1 AI6 2 TYR C 497 SER C 504 0
SHEET 2 AI6 2 VAL C 555 VAL C 561 -1 O SER C 557 N LYS C 502
SHEET 1 AI7 2 VAL C 604 LEU C 608 0
SHEET 2 AI7 2 VAL C 611 GLY C 615 -1 O GLY C 613 N TYR C 606
SHEET 1 AI8 2 VAL C 631 TYR C 632 0
SHEET 2 AI8 2 LEU C 638 GLY C 640 -1 O GLY C 640 N VAL C 631
SHEET 1 AI9 3 LEU C 717 VAL C 724 0
SHEET 2 AI9 3 MET C 757 ILE C 762 1 O SER C 761 N VAL C 724
SHEET 3 AI9 3 LEU C 735 CYS C 736 -1 N CYS C 736 O ALA C 760
SHEET 1 AJ1 3 PHE C 788 GLN C 796 0
SHEET 2 AJ1 3 GLY C1133 TYR C1141 -1 O HIS C1138 N THR C 791
SHEET 3 AJ1 3 THR C1121 ASN C1129 -1 N VAL C1124 O VAL C1139
SHEET 1 AJ2 2 VAL C 802 VAL C 804 0
SHEET 2 AJ2 2 TYR C 932 VAL C 934 -1 O LYS C 933 N THR C 803
SHEET 1 AJ3 4 SER C1151 ALA C1152 0
SHEET 2 AJ3 4 GLY C1170 LYS C1174 -1 O PHE C1172 N ALA C1152
SHEET 3 AJ3 4 TRP C1184 GLY C1188 -1 O SER C1185 N ILE C1173
SHEET 4 AJ3 4 GLU C1195 PRO C1196 -1 O GLU C1195 N TYR C1186
SHEET 1 AJ4 2 LEU C1155 ASP C1157 0
SHEET 2 AJ4 2 GLN C1212 ILE C1214 1 O GLN C1212 N CYS C1156
SHEET 1 AJ5 2 CYS C1164 PRO C1167 0
SHEET 2 AJ5 2 THR C1202 VAL C1205 -1 O LYS C1203 N ALA C1166
SSBOND 1 CYS A 328 CYS A 339 1555 1555 2.03
SSBOND 2 CYS A 385 CYS A 394 1555 1555 2.03
SSBOND 3 CYS A 444 CYS A 447 1555 1555 2.03
SSBOND 4 CYS A 454 CYS A 472 1555 1555 2.03
SSBOND 5 CYS A 649 CYS A 762 1555 1555 2.03
SSBOND 6 CYS B 328 CYS B 339 1555 1555 2.03
SSBOND 7 CYS B 385 CYS B 394 1555 1555 2.03
SSBOND 8 CYS B 444 CYS B 447 1555 1555 2.03
SSBOND 9 CYS B 454 CYS B 472 1555 1555 2.03
SSBOND 10 CYS B 649 CYS B 762 1555 1555 2.03
SSBOND 11 CYS F 30 CYS F 195 1555 1555 2.03
SSBOND 12 CYS F 176 CYS F 214 1555 1555 2.03
SSBOND 13 CYS F 185 CYS F 237 1555 1555 2.03
SSBOND 14 CYS F 339 CYS F 349 1555 1555 2.03
SSBOND 15 CYS F 383 CYS F 407 1555 1555 2.03
SSBOND 16 CYS F 425 CYS F 478 1555 1555 2.03
SSBOND 17 CYS F 437 CYS F 585 1555 1555 2.03
SSBOND 18 CYS F 503 CYS F 526 1555 1555 2.03
SSBOND 19 CYS F 603 CYS F 654 1555 1555 2.03
SSBOND 20 CYS F 620 CYS F 650 1555 1555 2.03
SSBOND 21 CYS F 679 CYS F 713 1555 1555 2.03
SSBOND 22 CYS F 727 CYS F 736 1555 1555 2.03
SSBOND 23 CYS F 806 CYS F 828 1555 1555 2.03
SSBOND 24 CYS F 811 CYS F 817 1555 1555 2.03
SSBOND 25 CYS F 912 CYS F 925 1555 1555 2.03
SSBOND 26 CYS F 1106 CYS F 1117 1555 1555 2.03
SSBOND 27 CYS F 1156 CYS F 1164 1555 1555 2.03
SSBOND 28 CYS G 30 CYS G 195 1555 1555 2.03
SSBOND 29 CYS G 176 CYS G 214 1555 1555 2.03
SSBOND 30 CYS G 185 CYS G 237 1555 1555 2.03
SSBOND 31 CYS G 339 CYS G 349 1555 1555 2.03
SSBOND 32 CYS G 383 CYS G 407 1555 1555 2.02
SSBOND 33 CYS G 425 CYS G 478 1555 1555 2.03
SSBOND 34 CYS G 437 CYS G 585 1555 1555 2.03
SSBOND 35 CYS G 503 CYS G 526 1555 1555 2.03
SSBOND 36 CYS G 603 CYS G 654 1555 1555 2.03
SSBOND 37 CYS G 620 CYS G 650 1555 1555 2.03
SSBOND 38 CYS G 679 CYS G 713 1555 1555 2.03
SSBOND 39 CYS G 727 CYS G 736 1555 1555 2.03
SSBOND 40 CYS G 806 CYS G 828 1555 1555 2.03
SSBOND 41 CYS G 811 CYS G 817 1555 1555 2.03
SSBOND 42 CYS G 912 CYS G 925 1555 1555 2.03
SSBOND 43 CYS G 1106 CYS G 1117 1555 1555 2.03
SSBOND 44 CYS G 1156 CYS G 1164 1555 1555 2.03
SSBOND 45 CYS C 30 CYS C 195 1555 1555 2.03
SSBOND 46 CYS C 176 CYS C 214 1555 1555 2.03
SSBOND 47 CYS C 185 CYS C 237 1555 1555 2.03
SSBOND 48 CYS C 339 CYS C 349 1555 1555 2.03
SSBOND 49 CYS C 383 CYS C 407 1555 1555 2.03
SSBOND 50 CYS C 425 CYS C 478 1555 1555 2.03
SSBOND 51 CYS C 437 CYS C 585 1555 1555 2.03
SSBOND 52 CYS C 503 CYS C 526 1555 1555 2.03
SSBOND 53 CYS C 603 CYS C 654 1555 1555 2.03
SSBOND 54 CYS C 620 CYS C 650 1555 1555 2.03
SSBOND 55 CYS C 679 CYS C 713 1555 1555 2.03
SSBOND 56 CYS C 727 CYS C 736 1555 1555 2.03
SSBOND 57 CYS C 806 CYS C 828 1555 1555 2.03
SSBOND 58 CYS C 811 CYS C 817 1555 1555 2.03
SSBOND 59 CYS C 912 CYS C 925 1555 1555 2.03
SSBOND 60 CYS C 1106 CYS C 1117 1555 1555 2.03
SSBOND 61 CYS C 1156 CYS C 1164 1555 1555 2.03
CISPEP 1 GLY A 474 PRO A 475 0 -1.60
CISPEP 2 GLY B 474 PRO B 475 0 -0.59
CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 1.000000 0.000000 0.000000 0.00000
SCALE2 0.000000 1.000000 0.000000 0.00000
SCALE3 0.000000 0.000000 1.000000 0.00000
TER 5964 PRO A 766
TER 11928 PRO B 766
TER 21261 GLY F1224
TER 30594 GLY G1224
TER 39927 GLY C1224
MASTER 704 0 0 110 264 0 0 639922 5 122 434
END |