longtext: 2B20-pdb

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HEADER    TRANSPORT PROTEIN                       16-SEP-05   2B20
TITLE     CRYSTAL STRUCTURE OF ENTEROCHELIN ESTERASE FROM SHIGELLA
TITLE    2 FLEXNERI ENTEROCHELIN ESTERASE
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: ENTEROCHELIN ESTERASE;
COMPND   3 CHAIN: A;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: SHIGELLA FLEXNERI 2A STR. 2457T;
SOURCE   3 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   4 EXPRESSION_SYSTEM_COMMON: BACTERIA;
SOURCE   5 EXPRESSION_SYSTEM_STRAIN: BL21DE3;
SOURCE   6 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE   7 EXPRESSION_SYSTEM_PLASMID: PMCSG7
KEYWDS    ALPHA-BETA-ALPHA-SANDWICH, STRUCTURAL GENOMICS, PSI,
KEYWDS   2 PROTEIN STRUCTURE INITIATIVE, MIDWEST CENTER FOR STRUCTURAL
KEYWDS   3 GENOMICS, MCSG
EXPDTA    X-RAY DIFFRACTION
AUTHOR    Y.KIM,N.MALTSEVA,I.DEMENTIEVA,P.QUARTEY,D.HOLZLE,F.COLLART,
AUTHOR   2 A.JOACHIMIAK,MIDWEST CENTER FOR STRUCTURAL GENOMICS (MCSG)
REVDAT   1   01-NOV-05 2B20    0
JRNL        AUTH   Y.KIM,N.MALTSEVA,I.DEMENTIEVA,P.QUARTEY,D.HOLZLE,
JRNL        AUTH 2 F.COLLART,A.JOACHIMIAK
JRNL        TITL   CRYSTAL STRUCTURE OF ENTEROCHELIN ESTERASE FROM
JRNL        TITL 2 SHIGELLA FLEXNERI ENTEROCHELIN ESTERASE
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   1
REMARK   2
REMARK   2 RESOLUTION. 2.95 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : CNS,REFMAC 5.2.0005
REMARK   3   AUTHORS     : BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE-
REMARK   3               : KUNSTLEVE,JIANG,KUSZEWSKI,NILGES, PANNU,
REMARK   3               : READ,RICE,SIMONSON,WARREN
REMARK   3
REMARK   3  REFINEMENT TARGET : MAXIMUM LIKELIHOOD WITH PHASES
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.95
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 40.11
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000
REMARK   3   DATA CUTOFF HIGH         (ABS(F)) : NULL
REMARK   3   DATA CUTOFF LOW          (ABS(F)) : NULL
REMARK   3   COMPLETENESS (WORKING+TEST)   (%) : 99.7
REMARK   3   NUMBER OF REFLECTIONS             : 11946
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE            (WORKING SET) : 0.222
REMARK   3   FREE R VALUE                     : 0.277
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.900
REMARK   3   FREE R VALUE TEST SET COUNT      : 611
REMARK   3   ESTIMATED ERROR OF FREE R VALUE  : NULL
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.95
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 3.03
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 98.67
REMARK   3   REFLECTIONS IN BIN    (WORKING SET) : 841
REMARK   3   BIN R VALUE           (WORKING SET) : 0.3140
REMARK   3   BIN FREE R VALUE                    : 0.3520
REMARK   3   BIN FREE R VALUE TEST SET SIZE  (%) : NULL
REMARK   3   BIN FREE R VALUE TEST SET COUNT     : 47
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE : NULL
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 3218
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 10
REMARK   3   SOLVENT ATOMS            : 50
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 81.51
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : 0.46000
REMARK   3    B22 (A**2) : 0.46000
REMARK   3    B33 (A**2) : -0.91000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED COORDINATE ERROR.
REMARK   3   ESD FROM LUZZATI PLOT        (A) : NULL
REMARK   3   ESD FROM SIGMAA              (A) : NULL
REMARK   3   LOW RESOLUTION CUTOFF        (A) : NULL
REMARK   3
REMARK   3  CROSS-VALIDATED ESTIMATED COORDINATE ERROR.
REMARK   3   ESD FROM C-V LUZZATI PLOT    (A) : NULL
REMARK   3   ESD FROM C-V SIGMAA          (A) : NULL
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES.
REMARK   3   BOND LENGTHS                 (A) : NULL
REMARK   3   BOND ANGLES            (DEGREES) : NULL
REMARK   3   DIHEDRAL ANGLES        (DEGREES) : NULL
REMARK   3   IMPROPER ANGLES        (DEGREES) : NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL MODEL : NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.    RMS    SIGMA
REMARK   3   MAIN-CHAIN BOND              (A**2) : NULL  ; NULL
REMARK   3   MAIN-CHAIN ANGLE             (A**2) : NULL  ; NULL
REMARK   3   SIDE-CHAIN BOND              (A**2) : NULL  ; NULL
REMARK   3   SIDE-CHAIN ANGLE             (A**2) : NULL  ; NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELING.
REMARK   3   METHOD USED : MASK
REMARK   3   KSOL        : NULL
REMARK   3   BSOL        : NULL
REMARK   3
REMARK   3  NCS MODEL : NULL
REMARK   3
REMARK   3  NCS RESTRAINTS.                         RMS   SIGMA/WEIGHT
REMARK   3   GROUP  1  POSITIONAL            (A) : NULL  ; NULL
REMARK   3   GROUP  1  B-FACTOR           (A**2) : NULL  ; NULL
REMARK   3
REMARK   3  PARAMETER FILE  1  : NULL
REMARK   3  TOPOLOGY FILE  1   : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE
REMARK   3  RIDING POSITIONS
REMARK   4
REMARK   4 2B20 COMPLIES WITH FORMAT V. 2.3, 09-JULY-1998
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 19-SEP-2005.
REMARK 100 THE RCSB ID CODE IS RCSB034576.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 11-MAR-2005
REMARK 200  TEMPERATURE           (KELVIN) : 100.0
REMARK 200  PH                             : 9.50
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : APS
REMARK 200  BEAMLINE                       : 19ID
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9794
REMARK 200  MONOCHROMATOR                  : DOUBLE CRYSTAL MONOCHROMATOR
REMARK 200  OPTICS                         : MIRRORS
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC Q315
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : SBCCOLLECT
REMARK 200  DATA SCALING SOFTWARE          : HKL2000
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 12690
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.950
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 0.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.8
REMARK 200  DATA REDUNDANCY                : 20.600
REMARK 200  R MERGE                    (I) : 0.11000
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 8.4000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.95
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 3.06
REMARK 200  COMPLETENESS FOR SHELL     (%) : 99.0
REMARK 200  DATA REDUNDANCY IN SHELL       : 16.60
REMARK 200  R MERGE FOR SHELL          (I) : 0.96900
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 2.900
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: SAD
REMARK 200 SOFTWARE USED: HKL2000_PH, SHELX,SOLVE
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 60.80
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.10
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: POTASSIUM/SODIUM TARTRATE, CHES,
REMARK 280  LITIUM SULFATE, PH 9.5, VAPOR DIFFUSION, SITTING DROP,
REMARK 280  TEMPERATURE 277K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 43 21 2
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,-Y,1/2+Z
REMARK 290       3555   1/2-Y,1/2+X,3/4+Z
REMARK 290       4555   1/2+Y,1/2-X,1/4+Z
REMARK 290       5555   1/2-X,1/2+Y,3/4-Z
REMARK 290       6555   1/2+X,1/2-Y,1/4-Z
REMARK 290       7555   Y,X,-Z
REMARK 290       8555   -Y,-X,1/2-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000      126.06250
REMARK 290   SMTRY1   3  0.000000 -1.000000  0.000000       33.08650
REMARK 290   SMTRY2   3  1.000000  0.000000  0.000000       33.08650
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000      189.09375
REMARK 290   SMTRY1   4  0.000000  1.000000  0.000000       33.08650
REMARK 290   SMTRY2   4 -1.000000  0.000000  0.000000       33.08650
REMARK 290   SMTRY3   4  0.000000  0.000000  1.000000       63.03125
REMARK 290   SMTRY1   5 -1.000000  0.000000  0.000000       33.08650
REMARK 290   SMTRY2   5  0.000000  1.000000  0.000000       33.08650
REMARK 290   SMTRY3   5  0.000000  0.000000 -1.000000      189.09375
REMARK 290   SMTRY1   6  1.000000  0.000000  0.000000       33.08650
REMARK 290   SMTRY2   6  0.000000 -1.000000  0.000000       33.08650
REMARK 290   SMTRY3   6  0.000000  0.000000 -1.000000       63.03125
REMARK 290   SMTRY1   7  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY2   7  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   7  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   8  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY2   8 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   8  0.000000  0.000000 -1.000000      126.06250
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT
REMARK 300 WHICH CONSISTS OF 1 CHAIN(S). SEE REMARK 350 FOR
REMARK 300 INFORMATION ON GENERATING THE BIOLOGICAL MOLECULE(S).
REMARK 350
REMARK 350 GENERATING THE BIOMOLECULE
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     SER A    -2
REMARK 465     ASN A    -1
REMARK 465     ALA A     0
REMARK 465     MSE A     1
REMARK 465     THR A     2
REMARK 465     ASN A    62
REMARK 465     SER A    63
REMARK 465     ALA A   191
REMARK 465     GLU A   192
REMARK 465     ASP A   398
REMARK 465     ARG A   399
REMARK 465     SER A   400
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI
REMARK 500   N    ILE A   235     O    HOH      16              1.95
REMARK 500   NH2  ARG A   369     OD1  ASP A   390              2.02
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES: ENGH AND HUBER, 1991
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    HIS A  60   N   -  CA  -  C   ANGL. DEV. = 11.9 DEGREES
REMARK 500    ASP A 188   N   -  CA  -  C   ANGL. DEV. = 10.3 DEGREES
REMARK 500    ALA A 234   N   -  CA  -  C   ANGL. DEV. =-11.7 DEGREES
REMARK 500    LEU A 335   CA  -  CB  -  CG  ANGL. DEV. = 10.7 DEGREES
REMARK 500    GLU A 345   N   -  CA  -  C   ANGL. DEV. = 13.0 DEGREES
REMARK 500    PRO A 346   N   -  CA  -  C   ANGL. DEV. = -9.1 DEGREES
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    SER A 281     -116.05     41.19
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500                                 MODEL     OMEGA
REMARK 500 GLU A  345    PRO A  346                  -78.51
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: APC27316   RELATED DB: TARGETDB
DBREF  2B20 A    1   400  GB     30040286 AAP16019         1    400
SEQADV 2B20 SER A   -2  GB   30040286            CLONING ARTIFACT
SEQADV 2B20 ASN A   -1  GB   30040286            CLONING ARTIFACT
SEQADV 2B20 ALA A    0  GB   30040286            CLONING ARTIFACT
SEQADV 2B20 MSE A    1  GB   30040286  MET     1 MODIFIED RESIDUE
SEQADV 2B20 MSE A   27  GB   30040286  MET    27 MODIFIED RESIDUE
SEQADV 2B20 MSE A   68  GB   30040286  MET    68 MODIFIED RESIDUE
SEQADV 2B20 MSE A  146  GB   30040286  MET   146 MODIFIED RESIDUE
SEQADV 2B20 MSE A  209  GB   30040286  MET   209 MODIFIED RESIDUE
SEQADV 2B20 MSE A  347  GB   30040286  MET   347 MODIFIED RESIDUE
SEQADV 2B20 MSE A  349  GB   30040286  MET   349 MODIFIED RESIDUE
SEQADV 2B20 MSE A  385  GB   30040286  MET   385 MODIFIED RESIDUE
SEQRES   1 A  403  SER ASN ALA MSE THR ALA LEU LYS VAL GLY SER GLU SER
SEQRES   2 A  403  TRP TRP GLN SER LYS HIS GLY PRO GLU TRP GLN ARG LEU
SEQRES   3 A  403  ASN ASP GLU MSE PHE GLU VAL THR PHE TRP TRP ARG ASP
SEQRES   4 A  403  PRO GLN GLY SER GLU GLU TYR SER THR ILE LYS ARG VAL
SEQRES   5 A  403  TRP VAL TYR ILE THR GLY VAL THR ASP HIS HIS GLN ASN
SEQRES   6 A  403  SER GLN PRO GLN SER MSE GLN ARG ILE ALA GLY THR ASP
SEQRES   7 A  403  VAL TRP GLN TRP THR THR GLN LEU ASN ALA ASN TRP ARG
SEQRES   8 A  403  GLY SER TYR CYS PHE ILE PRO THR GLU ARG ASP ASP ILE
SEQRES   9 A  403  PHE SER ALA PRO SER PRO ASP ARG LEU GLU LEU ARG GLU
SEQRES  10 A  403  GLY TRP ARG LYS LEU LEU PRO GLN ALA ILE ALA ASP PRO
SEQRES  11 A  403  LEU ASN PRO GLN SER TRP LYS GLY GLY LEU GLY HIS ALA
SEQRES  12 A  403  VAL SER ALA LEU GLU MSE PRO GLN ALA PRO LEU GLN PRO
SEQRES  13 A  403  GLY TRP ASP CYS PRO GLN ALA PRO GLU ILE PRO ALA LYS
SEQRES  14 A  403  GLU ILE ILE TRP LYS SER GLU ARG LEU LYS ASN SER ARG
SEQRES  15 A  403  ARG VAL TRP ILE PHE THR THR GLY ASP VAL THR ALA GLU
SEQRES  16 A  403  GLU ARG PRO LEU ALA VAL LEU LEU ASP GLY GLU PHE TRP
SEQRES  17 A  403  ALA GLN SER MSE PRO VAL TRP PRO VAL LEU THR SER LEU
SEQRES  18 A  403  THR HIS ARG GLN GLN LEU PRO PRO ALA VAL TYR VAL LEU
SEQRES  19 A  403  ILE ASP ALA ILE ASP THR THR HIS ARG ALA HIS GLU LEU
SEQRES  20 A  403  PRO CYS ASN ALA ASP PHE TRP LEU ALA VAL GLN GLN GLU
SEQRES  21 A  403  LEU LEU PRO LEU VAL LYS VAL ILE ALA PRO PHE SER ASP
SEQRES  22 A  403  ARG ALA ASP ARG THR VAL VAL ALA GLY GLN SER PHE GLY
SEQRES  23 A  403  GLY LEU SER ALA LEU TYR ALA GLY LEU HIS TRP PRO GLU
SEQRES  24 A  403  ARG PHE GLY CYS VAL LEU SER GLN SER GLY SER TYR TRP
SEQRES  25 A  403  TRP PRO HIS ARG GLY GLY GLN GLN GLU GLY VAL LEU LEU
SEQRES  26 A  403  GLU LYS LEU LYS ALA GLY GLU VAL SER ALA GLU GLY LEU
SEQRES  27 A  403  ARG ILE VAL LEU GLU ALA GLY ILE ARG GLU PRO MSE ILE
SEQRES  28 A  403  MSE ARG ALA ASN GLN ALA LEU TYR ALA GLN LEU HIS PRO
SEQRES  29 A  403  ILE LYS GLU SER ILE PHE TRP ARG GLN VAL ASP GLY GLY
SEQRES  30 A  403  HIS ASP ALA LEU CYS TRP ARG GLY GLY LEU MSE GLN GLY
SEQRES  31 A  403  LEU ILE ASP LEU TRP GLN PRO LEU PHE HIS ASP ARG SER
MODRES 2B20 MSE A   27  MET  SELENOMETHIONINE
MODRES 2B20 MSE A   68  MET  SELENOMETHIONINE
MODRES 2B20 MSE A  146  MET  SELENOMETHIONINE
MODRES 2B20 MSE A  209  MET  SELENOMETHIONINE
MODRES 2B20 MSE A  347  MET  SELENOMETHIONINE
MODRES 2B20 MSE A  349  MET  SELENOMETHIONINE
MODRES 2B20 MSE A  385  MET  SELENOMETHIONINE
HET    MSE  A  27       8
HET    MSE  A  68       8
HET    MSE  A 146       8
HET    MSE  A 209       8
HET    MSE  A 347       8
HET    MSE  A 349       8
HET    MSE  A 385       8
HET    TAR    501      10
HETNAM     MSE SELENOMETHIONINE
HETNAM     TAR D(-)-TARTARIC ACID
FORMUL   1  MSE    7(C5 H11 N1 O2 SE1)
FORMUL   2  TAR    C4 H6 O6
FORMUL   3  HOH   *50(H2 O1)
HELIX    1   1 SER A    8  SER A   14  1                                   7
HELIX    2   2 VAL A   56  HIS A   60  5                                   5
HELIX    3   3 ASP A  108  LEU A  120  1                                  13
HELIX    4   4 PRO A  121  ALA A  123  5                                   3
HELIX    5   5 ASP A  201  SER A  208  1                                   8
HELIX    6   6 VAL A  211  ARG A  221  1                                  11
HELIX    7   7 ASP A  236  LEU A  244  1                                   9
HELIX    8   8 ASN A  247  GLU A  257  1                                  11
HELIX    9   9 GLU A  257  ALA A  266  1                                  10
HELIX   10  10 ARG A  271  ARG A  274  5                                   4
HELIX   11  11 SER A  281  TRP A  294  1                                  14
HELIX   12  12 LEU A  321  ALA A  327  1                                   7
HELIX   13  13 PRO A  346  GLN A  358  1                                  13
HELIX   14  14 LEU A  359  HIS A  360  5                                   2
HELIX   15  15 PRO A  361  GLU A  364  5                                   4
HELIX   16  16 ASP A  376  TRP A  392  1                                  17
HELIX   17  17 GLN A  393  PHE A  396  5                                   4
SHEET    1   A 4 GLU A  19  ARG A  22  0
SHEET    2   A 4 MSE A  27  ARG A  35 -1  O  GLU A  29   N  GLN A  21
SHEET    3   A 4 VAL A  76  ASN A  84 -1  O  TRP A  79   N  PHE A  32
SHEET    4   A 4 GLN A  69  ARG A  70 -1  N  GLN A  69   O  GLN A  78
SHEET    1   B 4 ARG A  48  ILE A  53  0
SHEET    2   B 4 ARG A  88  THR A  96 -1  O  THR A  96   N  ARG A  48
SHEET    3   B 4 ALA A 140  GLU A 145 -1  O  SER A 142   N  TYR A  91
SHEET    4   B 4 SER A 132  LYS A 134 -1  N  TRP A 133   O  VAL A 141
SHEET    1   C 8 LYS A 166  SER A 172  0
SHEET    2   C 8 ASN A 177  THR A 185 -1  O  VAL A 181   N  ILE A 168
SHEET    3   C 8 VAL A 228  ILE A 232 -1  O  TYR A 229   N  PHE A 184
SHEET    4   C 8 LEU A 196  LEU A 200  1  N  ALA A 197   O  VAL A 230
SHEET    5   C 8 VAL A 276  GLN A 280  1  O  ALA A 278   N  VAL A 198
SHEET    6   C 8 CYS A 300  GLN A 304  1  O  CYS A 300   N  VAL A 277
SHEET    7   C 8 ARG A 336  GLY A 342  1  O  VAL A 338   N  VAL A 301
SHEET    8   C 8 ILE A 366  VAL A 371  1  O  PHE A 367   N  LEU A 339
CISPEP   1 SER A  106    PRO A  107          0       -28.74
CISPEP   2 TRP A  310    PRO A  311          0        -1.81
CRYST1   66.173   66.173  252.125  90.00  90.00  90.00 P 43 21 2     8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.015112  0.000000  0.000000        0.00000
SCALE2      0.000000  0.015112  0.000000        0.00000
SCALE3      0.000000  0.000000  0.003966        0.00000
TER    3219      HIS A 397
MASTER      300    0    8   17   16    0    0    6 3278    1   66   31
END