longtext: 2D81-pdb

content
HEADER    HYDROLASE                               30-NOV-05   2D81
TITLE     PHB DEPOLYMERASE (S39A) COMPLEXED WITH R3HB TRIMER
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: PHB DEPOLYMERASE;
COMPND   3 CHAIN: A;
COMPND   4 EC: 3.1.1.75;
COMPND   5 ENGINEERED: YES;
COMPND   6 MUTATION: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: PENICILLIUM FUNICULOSUM;
SOURCE   3 ORGANISM_COMMON: FUNGI;
SOURCE   4 STRAIN: IFO 6345;
SOURCE   5 GENE: PHAZ;
SOURCE   6 EXPRESSION_SYSTEM: PICHIA PASTORIS;
SOURCE   7 EXPRESSION_SYSTEM_COMMON: YEAST;
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: KM71H;
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PPICZAB
KEYWDS    ALPHA/BETA HYDROLASE FOLD, CIRCULAR PERMUTATION
EXPDTA    X-RAY DIFFRACTION
AUTHOR    T.HISANO,K.KASUYA,T.SAITO,T.IWATA,K.MIKI
REVDAT   1   31-JAN-06 2D81    0
JRNL        AUTH   T.HISANO,K.KASUYA,Y.TEZUKA,N.ISHII,T.KOBAYASHI,
JRNL        AUTH 2 M.SHIRAKI,E.OROUDJEV,H.HANSMA,T.IWATA,Y.DOI,
JRNL        AUTH 3 T.SAITO,K.MIKI
JRNL        TITL   THE CRYSTAL STRUCTURE OF POLYHYDROXYBUTYRATE
JRNL        TITL 2 DEPOLYMERASE FROM PENICILLIUM FUNICULOSUM PROVIDES
JRNL        TITL 3 INSIGHTS INTO THE RECOGNITION AND DEGRADATION OF
JRNL        TITL 4 BIOPOLYESTERS
JRNL        REF    J.MOL.BIOL.                                2006
JRNL        REFN   ASTM JMOBAK  UK ESSN 1089-8638
REMARK   1
REMARK   2
REMARK   2 RESOLUTION. 1.66 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : CNS 1.1
REMARK   3   AUTHORS     : BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE-
REMARK   3               : KUNSTLEVE,JIANG,KUSZEWSKI,NILGES, PANNU,
REMARK   3               : READ,RICE,SIMONSON,WARREN
REMARK   3
REMARK   3  REFINEMENT TARGET : ENGH & HUBER
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.66
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 40.84
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000
REMARK   3   DATA CUTOFF HIGH         (ABS(F)) : 1501929.570
REMARK   3   DATA CUTOFF LOW          (ABS(F)) : 0.0000
REMARK   3   COMPLETENESS (WORKING+TEST)   (%) : 97.9
REMARK   3   NUMBER OF REFLECTIONS             : 29362
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE            (WORKING SET) : 0.176
REMARK   3   FREE R VALUE                     : 0.203
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 10.000
REMARK   3   FREE R VALUE TEST SET COUNT      : 2930
REMARK   3   ESTIMATED ERROR OF FREE R VALUE  : 0.004
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 6
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 1.66
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 1.76
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 87.50
REMARK   3   REFLECTIONS IN BIN    (WORKING SET) : 3916
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2070
REMARK   3   BIN FREE R VALUE                    : 0.2610
REMARK   3   BIN FREE R VALUE TEST SET SIZE  (%) : 10.50
REMARK   3   BIN FREE R VALUE TEST SET COUNT     : 461
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE : 0.012
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 2356
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 33
REMARK   3   SOLVENT ATOMS            : 237
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 11.30
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 10.40
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -1.66000
REMARK   3    B22 (A**2) : -1.61000
REMARK   3    B33 (A**2) : 3.27000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 3.68000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED COORDINATE ERROR.
REMARK   3   ESD FROM LUZZATI PLOT        (A) : 0.16
REMARK   3   ESD FROM SIGMAA              (A) : 0.07
REMARK   3   LOW RESOLUTION CUTOFF        (A) : 5.00
REMARK   3
REMARK   3  CROSS-VALIDATED ESTIMATED COORDINATE ERROR.
REMARK   3   ESD FROM C-V LUZZATI PLOT    (A) : 0.19
REMARK   3   ESD FROM C-V SIGMAA          (A) : 0.13
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES.
REMARK   3   BOND LENGTHS                 (A) : 0.004
REMARK   3   BOND ANGLES            (DEGREES) : 0.90
REMARK   3   DIHEDRAL ANGLES        (DEGREES) : 25.00
REMARK   3   IMPROPER ANGLES        (DEGREES) : 0.71
REMARK   3
REMARK   3  ISOTROPIC THERMAL MODEL : RESTRAINED
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.    RMS    SIGMA
REMARK   3   MAIN-CHAIN BOND              (A**2) : 1.010 ; 1.500
REMARK   3   MAIN-CHAIN ANGLE             (A**2) : 1.420 ; 2.000
REMARK   3   SIDE-CHAIN BOND              (A**2) : 1.690 ; 2.000
REMARK   3   SIDE-CHAIN ANGLE             (A**2) : 2.330 ; 2.500
REMARK   3
REMARK   3  BULK SOLVENT MODELING.
REMARK   3   METHOD USED : FLAT MODEL
REMARK   3   KSOL        : 0.39
REMARK   3   BSOL        : 43.13
REMARK   3
REMARK   3  NCS MODEL : NULL
REMARK   3
REMARK   3  NCS RESTRAINTS.                         RMS   SIGMA/WEIGHT
REMARK   3   GROUP  1  POSITIONAL            (A) : NULL  ; NULL
REMARK   3   GROUP  1  B-FACTOR           (A**2) : NULL  ; NULL
REMARK   3
REMARK   3  PARAMETER FILE  1  : PROTEIN_REP.PARAM_DIH
REMARK   3  PARAMETER FILE  2  : WATER_REP.PARAM
REMARK   3  PARAMETER FILE  3  : CARBOHYDRATE.PARAM
REMARK   3  PARAMETER FILE  4  : R3HBTRI2_PRODRG.PARAM_DIH
REMARK   3  PARAMETER FILE  5  : NULL
REMARK   3  TOPOLOGY FILE  1   : PROTEIN.TOP_DIH
REMARK   3  TOPOLOGY FILE  2   : WATER.TOP
REMARK   3  TOPOLOGY FILE  3   : CARBOHYDRATE.TOP
REMARK   3  TOPOLOGY FILE  4   : R3HBTRI2_PRODRG.TOP
REMARK   3  TOPOLOGY FILE  5   : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 2D81 COMPLIES WITH FORMAT V. 2.3, 09-JULY-1998
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 12-DEC-2005.
REMARK 100 THE RCSB ID CODE IS RCSB025102.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 12-JUL-2005
REMARK 200  TEMPERATURE           (KELVIN) : 90.0
REMARK 200  PH                             : 4.50
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SPRING-8
REMARK 200  BEAMLINE                       : BL44B2
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.0000
REMARK 200  MONOCHROMATOR                  : SI 111
REMARK 200  OPTICS                         : MIRRORS
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 4
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : MOSFLM
REMARK 200  DATA SCALING SOFTWARE          : SCALEPACK
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 29362
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.660
REMARK 200  RESOLUTION RANGE LOW       (A) : 40.840
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 0.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.3
REMARK 200  DATA REDUNDANCY                : NULL
REMARK 200  R MERGE                    (I) : 0.08400
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 25.9000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.66
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.72
REMARK 200  COMPLETENESS FOR SHELL     (%) : 89.9
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : 0.26200
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 0.262
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: MOLREP
REMARK 200 STARTING MODEL: PDB ENTRY 2D80
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 35.64
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 1.91
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 2.0M SODIUM CHLORIDE, 0.1M ACETATE-
REMARK 280  NAOH, 5% 1,4-DIOXANE, PH 4.5, VAPOR DIFFUSION, SITTING DROP,
REMARK 280  TEMPERATURE 294K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 1 2 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y,-Z
REMARK 290       3555   1/2+X,1/2+Y,Z
REMARK 290       4555   1/2-X,1/2+Y,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   3  1.000000  0.000000  0.000000       40.96700
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       24.43150
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000       40.96700
REMARK 290   SMTRY2   4  0.000000  1.000000  0.000000       24.43150
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT
REMARK 300 WHICH CONSISTS OF 1 CHAIN(S). SEE REMARK 350 FOR
REMARK 300 INFORMATION ON GENERATING THE BIOLOGICAL MOLECULE(S).
REMARK 350
REMARK 350 GENERATING THE BIOMOLECULE
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),F6.3)
REMARK 500
REMARK 500 EXPECTED VALUES: ENGH AND HUBER, 1991
REMARK 500
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION
REMARK 500    PRO A 281   CB    PRO A 281   CG     0.029
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES: ENGH AND HUBER, 1991
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    PRO A 175   C   -  N   -  CA  ANGL. DEV. =  5.8 DEGREES
REMARK 500    ILE A 177   N   -  CA  -  C   ANGL. DEV. = -5.2 DEGREES
REMARK 500    CYS A 250   CA  -  CB  -  SG  ANGL. DEV. =  5.9 DEGREES
REMARK 500    CYS A 304   CA  -  CB  -  SG  ANGL. DEV. =  5.4 DEGREES
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ALA A  39     -115.44     61.22
REMARK 600
REMARK 600 HETEROGEN
REMARK 600 THE METHYL GROUP LINKED TO THE TERMINAL CARBOXYL OXYGEN
REMARK 600 (O1M) IS NOT INCLUDED IN THE MODEL DUE TO DISORDER.
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 2D80   RELATED DB: PDB
REMARK 900 THE SAME PROTEIN OF WILD TYPE
REMARK 999
REMARK 999 SEQUENCE
REMARK 999 A SEQUENCE DATABASE REFERENCE FOR THIS PROTEIN DOES
REMARK 999  NOT CURRENTLY EXIST.
REMARK 999 THIS SEQUENCE WILL BE DEPOSITED IN THE SEQUENCE DATABASE.
SEQRES   1 A  318  THR ALA LEU PRO ALA PHE ASN VAL ASN PRO ASN SER VAL
SEQRES   2 A  318  SER VAL SER GLY LEU ALA SER GLY GLY TYR MET ALA ALA
SEQRES   3 A  318  GLN LEU GLY VAL ALA TYR SER ASP VAL PHE ASN VAL GLY
SEQRES   4 A  318  PHE GLY VAL PHE ALA GLY GLY PRO TYR ASP CYS ALA ARG
SEQRES   5 A  318  ASN GLN TYR TYR THR SER CYS MET TYR ASN GLY TYR PRO
SEQRES   6 A  318  SER ILE THR THR PRO THR ALA ASN MET LYS SER TRP SER
SEQRES   7 A  318  GLY ASN GLN ILE ALA SER VAL ALA ASN LEU GLY GLN ARG
SEQRES   8 A  318  LYS ILE TYR MET TRP THR GLY SER SER ASP THR THR VAL
SEQRES   9 A  318  GLY PRO ASN VAL MET ASN GLN LEU LYS ALA GLN LEU GLY
SEQRES  10 A  318  ASN PHE ASP ASN SER ALA ASN VAL SER TYR VAL THR THR
SEQRES  11 A  318  THR GLY ALA VAL HIS THR PHE PRO THR ASP PHE ASN GLY
SEQRES  12 A  318  ALA GLY ASP ASN SER CYS SER LEU SER THR SER PRO TYR
SEQRES  13 A  318  ILE SER ASN CYS ASN TYR ASP GLY ALA GLY ALA ALA LEU
SEQRES  14 A  318  LYS TRP ILE TYR GLY SER LEU ASN ALA ARG ASN THR GLY
SEQRES  15 A  318  THR LEU SER GLY SER VAL LEU SER PHE ALA GLN SER GLY
SEQRES  16 A  318  SER TYR GLY ALA ASN GLY MET ASP THR THR GLY TYR LEU
SEQRES  17 A  318  TYR VAL PRO GLN SER CYS ALA SER GLY ALA THR VAL CYS
SEQRES  18 A  318  SER LEU HIS VAL ALA LEU HIS GLY CYS LEU GLN SER TYR
SEQRES  19 A  318  SER SER ILE GLY SER ARG PHE ILE GLN ASN THR GLY TYR
SEQRES  20 A  318  ASN LYS TRP ALA ASP THR ASN ASN MET ILE ILE LEU TYR
SEQRES  21 A  318  PRO GLN ALA ILE PRO ASP TYR THR ILE HIS ALA ILE TRP
SEQRES  22 A  318  ASN GLY GLY VAL LEU SER ASN PRO ASN GLY CYS TRP ASP
SEQRES  23 A  318  TRP VAL GLY TRP TYR GLY SER ASN ALA ASP GLN ILE GLY
SEQRES  24 A  318  GLY VAL GLN MET ALA ALA ILE VAL GLY GLN VAL LYS GLN
SEQRES  25 A  318  ILE VAL SER GLY PHE GLN
MODRES 2D81 ASN A  144  ASN  GLYCOSYLATION SITE
HET    NAG  A 401      14
HET    RB3    451      19
HETNAM     NAG N-ACETYL-D-GLUCOSAMINE
HETNAM     RB3 (1R)-3-{[(1R)-3-METHOXY-1-METHYL-3-OXOPROPYL]OXY}-1-
HETNAM   2 RB3  METHYL-3-OXOPROPYL (3R)-3-HYDROXYBUTANOATE
HETSYN     NAG NAG
HETSYN     RB3 METHYL (3R)-3-{[(3R)-3-{[(3R)-3-
HETSYN   2 RB3  HYDROXYBUTANOYL]OXY}BUTANOYL]OXY}BUTANOATE
FORMUL   2  NAG    C8 H15 N1 O6
FORMUL   3  RB3    C13 H22 O7
FORMUL   4  HOH   *237(H2 O1)
HELIX    1   1 ALA A   39  TYR A   52  1                                  14
HELIX    2   2 TYR A   75  MET A   80  5                                   6
HELIX    3   3 ILE A   87  SER A   98  1                                  12
HELIX    4   4 SER A  104  ARG A  111  5                                   8
HELIX    5   5 GLY A  125  GLY A  137  1                                  13
HELIX    6   6 ASN A  141  ALA A  143  5                                   3
HELIX    7   7 ASP A  183  GLY A  194  1                                  12
HELIX    8   8 SER A  214  GLY A  218  5                                   5
HELIX    9   9 PRO A  231  SER A  236  1                                   6
HELIX   10  10 SER A  253  GLY A  258  1                                   6
HELIX   11  11 SER A  259  THR A  265  1                                   7
HELIX   12  12 GLY A  266  ASP A  272  1                                   7
HELIX   13  13 GLY A  320  SER A  335  1                                  16
SHEET    1   A 8 VAL A 145  THR A 150  0
SHEET    2   A 8 LYS A 112  GLY A 118  1  N  MET A 115   O  VAL A 148
SHEET    3   A 8 GLY A  59  PHE A  63  1  N  VAL A  62   O  TYR A 114
SHEET    4   A 8 VAL A  28  LEU A  38  1  N  GLY A  37   O  PHE A  63
SHEET    5   A 8 CYS A 241  LEU A 247  1  O  VAL A 245   N  SER A  36
SHEET    6   A 8 MET A 276  TYR A 280  1  O  LEU A 279   N  ALA A 246
SHEET    7   A 8 THR A 225  VAL A 230 -1  N  TYR A 227   O  TYR A 280
SHEET    8   A 8 SER A 207  ALA A 212 -1  N  PHE A 211   O  GLY A 226
SHEET    1   B 2 PHE A 157  THR A 159  0
SHEET    2   B 2 ILE A 177  ASN A 179  1  O  SER A 178   N  PHE A 157
SHEET    1   C 2 ASP A 286  ALA A 291  0
SHEET    2   C 2 VAL A 297  ASN A 300 -1  O  ASN A 300   N  ASP A 286
SSBOND   1 CYS A   70    CYS A   79
SSBOND   2 CYS A  169    CYS A  180
SSBOND   3 CYS A  234    CYS A  241
SSBOND   4 CYS A  250    CYS A  304
LINK         ND2 ASN A 144                 C1  NAG A 401
CISPEP   1 SER A  174    PRO A  175          0         0.37
CRYST1   81.934   48.863   64.198  90.00  94.45  90.00 C 1 2 1       4
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.012205  0.000000  0.000950        0.00000
SCALE2      0.000000  0.020465  0.000000        0.00000
SCALE3      0.000000  0.000000  0.015624        0.00000
TER    2357      GLN A 338
MASTER      277    0    2   13   12    0    0    6 2626    1   42   25
END