longtext: 2HDW-pdb

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HEADER    HYDROLASE                               21-JUN-06   2HDW
TITLE     CRYSTAL STRUCTURE OF HYPOTHETICAL PROTEIN PA2218 FROM
TITLE    2 PSEUDOMONAS AERUGINOSA
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: HYPOTHETICAL PROTEIN PA2218;
COMPND   3 CHAIN: A, B;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: PSEUDOMONAS AERUGINOSA;
SOURCE   3 ORGANISM_COMMON: BACTERIA;
SOURCE   4 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   5 EXPRESSION_SYSTEM_COMMON: BACTERIA
KEYWDS    PA2218, ALPHA/BETA HYDROLASE FOLD, STRUCTURAL GENOMICS, PSI,
KEYWDS   2 PROTEIN STRUCTURE INITIATIVE, NEW YORK STRUCTURAL GENOMIX
KEYWDS   3 RESEARCH CONSORTIUM, NYSGXRC
EXPDTA    X-RAY DIFFRACTION
AUTHOR    A.A.FEDOROV,E.V.FEDOROV,U.RAMAGOPAL,S.C.ALMO,S.K.BURLEY,NEW
AUTHOR   2 YORK STRUCTURAL GENOMIX RESEARCH CONSORTIUM (NYSGXRC)
REVDAT   1   28-NOV-06 2HDW    0
JRNL        AUTH   A.A.FEDOROV,E.V.FEDOROV,U.RAMAGOPAL,S.C.ALMO
JRNL        TITL   CRYSTAL STRUCTURE OF HYPOTHETICAL PROTEIN PA2218
JRNL        TITL 2 FROM PSEUDOMONAS AERUGINOSA
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   1
REMARK   2
REMARK   2 RESOLUTION. 2.00 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : CNS 1.1
REMARK   3   AUTHORS     : BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE-
REMARK   3               : KUNSTLEVE,JIANG,KUSZEWSKI,NILGES, PANNU,
REMARK   3               : READ,RICE,SIMONSON,WARREN
REMARK   3
REMARK   3  REFINEMENT TARGET : ENGH & HUBER
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.00
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 22.72
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.100
REMARK   3   DATA CUTOFF HIGH         (ABS(F)) : 261609.240
REMARK   3   DATA CUTOFF LOW          (ABS(F)) : 0.0000
REMARK   3   COMPLETENESS (WORKING+TEST)   (%) : 98.5
REMARK   3   NUMBER OF REFLECTIONS             : 37451
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE            (WORKING SET) : 0.198
REMARK   3   FREE R VALUE                     : 0.231
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.100
REMARK   3   FREE R VALUE TEST SET COUNT      : 1904
REMARK   3   ESTIMATED ERROR OF FREE R VALUE  : 0.005
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 10
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.00
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.07
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 97.20
REMARK   3   REFLECTIONS IN BIN    (WORKING SET) : 3491
REMARK   3   BIN R VALUE           (WORKING SET) : 0.1980
REMARK   3   BIN FREE R VALUE                    : 0.2460
REMARK   3   BIN FREE R VALUE TEST SET SIZE  (%) : 5.10
REMARK   3   BIN FREE R VALUE TEST SET COUNT     : 187
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE : 0.018
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 5027
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 0
REMARK   3   SOLVENT ATOMS            : 194
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 6.40
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 14.20
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : 9.50000
REMARK   3    B22 (A**2) : -7.37000
REMARK   3    B33 (A**2) : -2.13000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 2.05000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED COORDINATE ERROR.
REMARK   3   ESD FROM LUZZATI PLOT        (A) : 0.22
REMARK   3   ESD FROM SIGMAA              (A) : 0.08
REMARK   3   LOW RESOLUTION CUTOFF        (A) : 5.00
REMARK   3
REMARK   3  CROSS-VALIDATED ESTIMATED COORDINATE ERROR.
REMARK   3   ESD FROM C-V LUZZATI PLOT    (A) : 0.27
REMARK   3   ESD FROM C-V SIGMAA          (A) : 0.16
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES.
REMARK   3   BOND LENGTHS                 (A) : 0.007
REMARK   3   BOND ANGLES            (DEGREES) : 1.40
REMARK   3   DIHEDRAL ANGLES        (DEGREES) : 23.40
REMARK   3   IMPROPER ANGLES        (DEGREES) : 0.86
REMARK   3
REMARK   3  ISOTROPIC THERMAL MODEL : RESTRAINED
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.    RMS    SIGMA
REMARK   3   MAIN-CHAIN BOND              (A**2) : 1.090 ; 1.500
REMARK   3   MAIN-CHAIN ANGLE             (A**2) : 1.530 ; 2.000
REMARK   3   SIDE-CHAIN BOND              (A**2) : 2.100 ; 2.000
REMARK   3   SIDE-CHAIN ANGLE             (A**2) : 2.530 ; 2.500
REMARK   3
REMARK   3  BULK SOLVENT MODELING.
REMARK   3   METHOD USED : FLAT MODEL
REMARK   3   KSOL        : 0.39
REMARK   3   BSOL        : 41.99
REMARK   3
REMARK   3  NCS MODEL : NULL
REMARK   3
REMARK   3  NCS RESTRAINTS.                         RMS   SIGMA/WEIGHT
REMARK   3   GROUP  1  POSITIONAL            (A) : NULL  ; NULL
REMARK   3   GROUP  1  B-FACTOR           (A**2) : NULL  ; NULL
REMARK   3
REMARK   3  PARAMETER FILE  1  : PROTEIN_REP.PARAM
REMARK   3  PARAMETER FILE  2  : WATER_REP.PARAM
REMARK   3  PARAMETER FILE  3  : ION.PARAM
REMARK   3  PARAMETER FILE  4  : NULL
REMARK   3  TOPOLOGY FILE  1   : PROTEIN.TOP
REMARK   3  TOPOLOGY FILE  2   : WATER.TOP
REMARK   3  TOPOLOGY FILE  3   : ION.TOP
REMARK   3  TOPOLOGY FILE  4   : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 2HDW COMPLIES WITH FORMAT V. 3.0, 1-DEC-2006
REMARK   4
REMARK   4 THIS IS THE REMEDIATED VERSION OF THIS PDB ENTRY.
REMARK   4 REMEDIATED DATA FILE REVISION 3.100 (2007-03-18)
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB .
REMARK 100 THE RCSB ID CODE IS RCSB038239.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : NULL
REMARK 200  TEMPERATURE           (KELVIN) : 100.0
REMARK 200  PH                             : 6.50
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : NSLS
REMARK 200  BEAMLINE                       : X4A
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.979, 0.97934, 0.97911,
REMARK 200                                   0.97166
REMARK 200  MONOCHROMATOR                  : GRAPHITE
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : NULL
REMARK 200  DETECTOR MANUFACTURER          : NULL
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : NULL
REMARK 200  DATA SCALING SOFTWARE          : NULL
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 37451
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.000
REMARK 200  RESOLUTION RANGE LOW       (A) : 23.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 0.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.5
REMARK 200  DATA REDUNDANCY                : NULL
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : NULL
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.00
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.07
REMARK 200  COMPLETENESS FOR SHELL     (%) : 97.2
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: MAD
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MAD
REMARK 200 SOFTWARE USED: SHELXD
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): NULL
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): NULL
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 20% PEG3350, 0.1M BIS-TRIS, 0.1M
REMARK 280  NACL, PH 6.5, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,1/2+Y,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       68.16850
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT
REMARK 300 WHICH CONSISTS OF 2 CHAIN(S). SEE REMARK 350 FOR
REMARK 300 INFORMATION ON GENERATING THE BIOLOGICAL MOLECULE(S).
REMARK 350
REMARK 350 GENERATING THE BIOMOLECULE
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350 BIOMOLECULE: 2
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A     1
REMARK 465     GLU A     2
REMARK 465     THR A     3
REMARK 465     LYS A     4
REMARK 465     HIS A     5
REMARK 465     SER A     6
REMARK 465     ASN A     7
REMARK 465     ARG A     8
REMARK 465     ALA A     9
REMARK 465     ARG A    10
REMARK 465     SER A    11
REMARK 465     ARG A    12
REMARK 465     LYS A    13
REMARK 465     GLY A    14
REMARK 465     ALA A    15
REMARK 465     LEU A    16
REMARK 465     ARG A    17
REMARK 465     GLY A    18
REMARK 465     ALA A    19
REMARK 465     VAL A    20
REMARK 465     LEU A    21
REMARK 465     ALA A    22
REMARK 465     GLY A    23
REMARK 465     ALA A    24
REMARK 465     LEU A    25
REMARK 465     MET A    26
REMARK 465     ALA A    27
REMARK 465     LEU A    28
REMARK 465     VAL A    29
REMARK 465     GLY A    30
REMARK 465     CYS A    31
REMARK 465     GLN A    32
REMARK 465     THR A    33
REMARK 465     SER A    34
REMARK 465     PRO A    35
REMARK 465     ALA A    36
REMARK 465     ALA A    37
REMARK 465     THR A    38
REMARK 465     THR A    39
REMARK 465     SER A    40
REMARK 465     SER A    41
REMARK 465     ASN A    42
REMARK 465     THR A    43
REMARK 465     GLY A    44
REMARK 465     GLY A    45
REMARK 465     THR A    46
REMARK 465     MET B     1
REMARK 465     GLU B     2
REMARK 465     THR B     3
REMARK 465     LYS B     4
REMARK 465     HIS B     5
REMARK 465     SER B     6
REMARK 465     ASN B     7
REMARK 465     ARG B     8
REMARK 465     ALA B     9
REMARK 465     ARG B    10
REMARK 465     SER B    11
REMARK 465     ARG B    12
REMARK 465     LYS B    13
REMARK 465     GLY B    14
REMARK 465     ALA B    15
REMARK 465     LEU B    16
REMARK 465     ARG B    17
REMARK 465     GLY B    18
REMARK 465     ALA B    19
REMARK 465     VAL B    20
REMARK 465     LEU B    21
REMARK 465     ALA B    22
REMARK 465     GLY B    23
REMARK 465     ALA B    24
REMARK 465     LEU B    25
REMARK 465     MET B    26
REMARK 465     ALA B    27
REMARK 465     LEU B    28
REMARK 465     VAL B    29
REMARK 465     GLY B    30
REMARK 465     CYS B    31
REMARK 465     GLN B    32
REMARK 465     THR B    33
REMARK 465     SER B    34
REMARK 465     PRO B    35
REMARK 465     ALA B    36
REMARK 465     ALA B    37
REMARK 465     THR B    38
REMARK 465     THR B    39
REMARK 465     SER B    40
REMARK 465     SER B    41
REMARK 465     ASN B    42
REMARK 465     THR B    43
REMARK 465     GLY B    44
REMARK 465     GLY B    45
REMARK 465     THR B    46
REMARK 465     ASN B    47
REMARK 465     MET B    48
REMARK 465     GLN B    49
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),F6.3)
REMARK 500
REMARK 500 EXPECTED VALUES: ENGH AND HUBER, 1991
REMARK 500
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION
REMARK 500    MET A 120   SD    MET A 120   CE    -0.093
REMARK 500    MET A 203   CG    MET A 203   SD     0.043
REMARK 500    MET A 206   CG    MET A 206   SD     0.042
REMARK 500    MET A 210   SD    MET A 210   CE    -0.046
REMARK 500    MET A 268   SD    MET A 268   CE     0.040
REMARK 500    MET A 293   SD    MET A 293   CE    -0.051
REMARK 500    MET B 120   SD    MET B 120   CE    -0.152
REMARK 500    MET B 203   CG    MET B 203   SD     0.047
REMARK 500    MET B 286   SD    MET B 286   CE    -0.048
REMARK 500    MET B 293   SD    MET B 293   CE    -0.049
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES: ENGH AND HUBER, 1991
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    PRO A  97   N   -  CA  -  C   ANGL. DEV. = -9.0 DEGREES
REMARK 500    VAL A 126   N   -  CA  -  C   ANGL. DEV. =-11.6 DEGREES
REMARK 500    VAL A 145   N   -  CA  -  C   ANGL. DEV. = -9.4 DEGREES
REMARK 500    TYR A 204   N   -  CA  -  C   ANGL. DEV. = -9.7 DEGREES
REMARK 500    ASP A 205   N   -  CA  -  C   ANGL. DEV. =-15.6 DEGREES
REMARK 500    ILE A 304   N   -  CA  -  C   ANGL. DEV. = -9.1 DEGREES
REMARK 500    PRO A 306   C   -  N   -  CA  ANGL. DEV. =  8.4 DEGREES
REMARK 500    PRO B  97   N   -  CA  -  C   ANGL. DEV. = -9.3 DEGREES
REMARK 500    SER B 112   N   -  CA  -  C   ANGL. DEV. =  8.4 DEGREES
REMARK 500    VAL B 126   N   -  CA  -  C   ANGL. DEV. =-11.6 DEGREES
REMARK 500    VAL B 145   N   -  CA  -  C   ANGL. DEV. =-10.4 DEGREES
REMARK 500    MET B 203   N   -  CA  -  C   ANGL. DEV. =  9.0 DEGREES
REMARK 500    TYR B 204   N   -  CA  -  C   ANGL. DEV. = -8.6 DEGREES
REMARK 500    ASP B 205   N   -  CA  -  C   ANGL. DEV. =-15.0 DEGREES
REMARK 500    ILE B 304   N   -  CA  -  C   ANGL. DEV. = -8.8 DEGREES
REMARK 500    ASP B 349   N   -  CA  -  C   ANGL. DEV. =  8.4 DEGREES
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: NYSGXRC-2896C   RELATED DB: TARGETDB
DBREF  2HDW A    1   367  UNP    Q01609   Y2218_PSEAE      5    371
DBREF  2HDW B    1   367  UNP    Q01609   Y2218_PSEAE      5    371
SEQRES   1 A  367  MET GLU THR LYS HIS SER ASN ARG ALA ARG SER ARG LYS
SEQRES   2 A  367  GLY ALA LEU ARG GLY ALA VAL LEU ALA GLY ALA LEU MET
SEQRES   3 A  367  ALA LEU VAL GLY CYS GLN THR SER PRO ALA ALA THR THR
SEQRES   4 A  367  SER SER ASN THR GLY GLY THR ASN MET GLN LEU GLN LEU
SEQRES   5 A  367  THR GLN GLU TRP ASP LYS THR PHE PRO LEU SER ALA LYS
SEQRES   6 A  367  VAL GLU HIS ARG LYS VAL THR PHE ALA ASN ARG TYR GLY
SEQRES   7 A  367  ILE THR LEU ALA ALA ASP LEU TYR LEU PRO LYS ASN ARG
SEQRES   8 A  367  GLY GLY ASP ARG LEU PRO ALA ILE VAL ILE GLY GLY PRO
SEQRES   9 A  367  PHE GLY ALA VAL LYS GLU GLN SER SER GLY LEU TYR ALA
SEQRES  10 A  367  GLN THR MET ALA GLU ARG GLY PHE VAL THR LEU ALA PHE
SEQRES  11 A  367  ASP PRO SER TYR THR GLY GLU SER GLY GLY GLN PRO ARG
SEQRES  12 A  367  ASN VAL ALA SER PRO ASP ILE ASN THR GLU ASP PHE SER
SEQRES  13 A  367  ALA ALA VAL ASP PHE ILE SER LEU LEU PRO GLU VAL ASN
SEQRES  14 A  367  ARG GLU ARG ILE GLY VAL ILE GLY ILE CYS GLY TRP GLY
SEQRES  15 A  367  GLY MET ALA LEU ASN ALA VAL ALA VAL ASP LYS ARG VAL
SEQRES  16 A  367  LYS ALA VAL VAL THR SER THR MET TYR ASP MET THR ARG
SEQRES  17 A  367  VAL MET SER LYS GLY TYR ASN ASP SER VAL THR LEU GLU
SEQRES  18 A  367  GLN ARG THR ARG THR LEU GLU GLN LEU GLY GLN GLN ARG
SEQRES  19 A  367  TRP LYS ASP ALA GLU SER GLY THR PRO ALA TYR GLN PRO
SEQRES  20 A  367  PRO TYR ASN GLU LEU LYS GLY GLY GLU ALA GLN PHE LEU
SEQRES  21 A  367  VAL ASP TYR HIS ASP TYR TYR MET THR PRO ARG GLY TYR
SEQRES  22 A  367  HIS PRO ARG ALA VAL ASN SER GLY ASN ALA TRP THR MET
SEQRES  23 A  367  THR THR PRO LEU SER PHE MET ASN MET PRO ILE LEU THR
SEQRES  24 A  367  TYR ILE LYS GLU ILE SER PRO ARG PRO ILE LEU LEU ILE
SEQRES  25 A  367  HIS GLY GLU ARG ALA HIS SER ARG TYR PHE SER GLU THR
SEQRES  26 A  367  ALA TYR ALA ALA ALA ALA GLU PRO LYS GLU LEU LEU ILE
SEQRES  27 A  367  VAL PRO GLY ALA SER HIS VAL ASP LEU TYR ASP ARG LEU
SEQRES  28 A  367  ASP ARG ILE PRO PHE ASP ARG ILE ALA GLY PHE PHE ASP
SEQRES  29 A  367  GLU HIS LEU
SEQRES   1 B  367  MET GLU THR LYS HIS SER ASN ARG ALA ARG SER ARG LYS
SEQRES   2 B  367  GLY ALA LEU ARG GLY ALA VAL LEU ALA GLY ALA LEU MET
SEQRES   3 B  367  ALA LEU VAL GLY CYS GLN THR SER PRO ALA ALA THR THR
SEQRES   4 B  367  SER SER ASN THR GLY GLY THR ASN MET GLN LEU GLN LEU
SEQRES   5 B  367  THR GLN GLU TRP ASP LYS THR PHE PRO LEU SER ALA LYS
SEQRES   6 B  367  VAL GLU HIS ARG LYS VAL THR PHE ALA ASN ARG TYR GLY
SEQRES   7 B  367  ILE THR LEU ALA ALA ASP LEU TYR LEU PRO LYS ASN ARG
SEQRES   8 B  367  GLY GLY ASP ARG LEU PRO ALA ILE VAL ILE GLY GLY PRO
SEQRES   9 B  367  PHE GLY ALA VAL LYS GLU GLN SER SER GLY LEU TYR ALA
SEQRES  10 B  367  GLN THR MET ALA GLU ARG GLY PHE VAL THR LEU ALA PHE
SEQRES  11 B  367  ASP PRO SER TYR THR GLY GLU SER GLY GLY GLN PRO ARG
SEQRES  12 B  367  ASN VAL ALA SER PRO ASP ILE ASN THR GLU ASP PHE SER
SEQRES  13 B  367  ALA ALA VAL ASP PHE ILE SER LEU LEU PRO GLU VAL ASN
SEQRES  14 B  367  ARG GLU ARG ILE GLY VAL ILE GLY ILE CYS GLY TRP GLY
SEQRES  15 B  367  GLY MET ALA LEU ASN ALA VAL ALA VAL ASP LYS ARG VAL
SEQRES  16 B  367  LYS ALA VAL VAL THR SER THR MET TYR ASP MET THR ARG
SEQRES  17 B  367  VAL MET SER LYS GLY TYR ASN ASP SER VAL THR LEU GLU
SEQRES  18 B  367  GLN ARG THR ARG THR LEU GLU GLN LEU GLY GLN GLN ARG
SEQRES  19 B  367  TRP LYS ASP ALA GLU SER GLY THR PRO ALA TYR GLN PRO
SEQRES  20 B  367  PRO TYR ASN GLU LEU LYS GLY GLY GLU ALA GLN PHE LEU
SEQRES  21 B  367  VAL ASP TYR HIS ASP TYR TYR MET THR PRO ARG GLY TYR
SEQRES  22 B  367  HIS PRO ARG ALA VAL ASN SER GLY ASN ALA TRP THR MET
SEQRES  23 B  367  THR THR PRO LEU SER PHE MET ASN MET PRO ILE LEU THR
SEQRES  24 B  367  TYR ILE LYS GLU ILE SER PRO ARG PRO ILE LEU LEU ILE
SEQRES  25 B  367  HIS GLY GLU ARG ALA HIS SER ARG TYR PHE SER GLU THR
SEQRES  26 B  367  ALA TYR ALA ALA ALA ALA GLU PRO LYS GLU LEU LEU ILE
SEQRES  27 B  367  VAL PRO GLY ALA SER HIS VAL ASP LEU TYR ASP ARG LEU
SEQRES  28 B  367  ASP ARG ILE PRO PHE ASP ARG ILE ALA GLY PHE PHE ASP
SEQRES  29 B  367  GLU HIS LEU
FORMUL   3  HOH   *194(H2 O)
HELIX    1   1 GLN A  111  ARG A  123  1                                  13
HELIX    2   2 SER A  147  LEU A  165  1                                  19
HELIX    3   3 GLY A  180  ASP A  192  1                                  13
HELIX    4   4 ASP A  205  GLY A  213  1                                   9
HELIX    5   5 THR A  219  GLY A  241  1                                  23
HELIX    6   6 ALA A  257  MET A  268  1                                  12
HELIX    7   7 THR A  288  MET A  293  1                                   6
HELIX    8   8 TYR A  300  SER A  305  5                                   6
HELIX    9   9 SER A  319  ALA A  330  1                                  12
HELIX   10  10 VAL A  345  ARG A  350  1                                   6
HELIX   11  11 PRO A  355  LEU A  367  1                                  13
HELIX   12  12 GLN B  111  ARG B  123  1                                  13
HELIX   13  13 SER B  147  SER B  163  1                                  17
HELIX   14  14 GLY B  180  ASP B  192  1                                  13
HELIX   15  15 ASP B  205  GLY B  213  1                                   9
HELIX   16  16 TYR B  214  SER B  217  5                                   4
HELIX   17  17 THR B  219  GLY B  241  1                                  23
HELIX   18  18 ALA B  257  MET B  268  1                                  12
HELIX   19  19 THR B  288  MET B  293  1                                   6
HELIX   20  20 TYR B  300  ILE B  304  5                                   5
HELIX   21  21 SER B  319  ALA B  330  1                                  12
HELIX   22  22 VAL B  345  ARG B  350  1                                   6
HELIX   23  23 PRO B  355  LEU B  367  1                                  13
SHEET    1   A 8 VAL A  66  ALA A  74  0
SHEET    2   A 8 THR A  80  PRO A  88 -1  O  LEU A  81   N  PHE A  73
SHEET    3   A 8 VAL A 126  PHE A 130 -1  O  THR A 127   N  TYR A  86
SHEET    4   A 8 LEU A  96  GLY A 102  1  N  ILE A 101   O  LEU A 128
SHEET    5   A 8 VAL A 168  ILE A 178  1  O  ARG A 172   N  ALA A  98
SHEET    6   A 8 ALA A 197  SER A 201  1  O  SER A 201   N  GLY A 177
SHEET    7   A 8 ILE A 309  GLY A 314  1  O  ILE A 312   N  THR A 200
SHEET    8   A 8 LYS A 334  VAL A 339  1  O  LEU A 337   N  LEU A 311
SHEET    1   B 8 VAL B  66  ALA B  74  0
SHEET    2   B 8 THR B  80  PRO B  88 -1  O  LEU B  81   N  PHE B  73
SHEET    3   B 8 VAL B 126  PHE B 130 -1  O  ALA B 129   N  ASP B  84
SHEET    4   B 8 LEU B  96  GLY B 102  1  N  ILE B 101   O  LEU B 128
SHEET    5   B 8 VAL B 168  ILE B 178  1  O  ILE B 178   N  GLY B 102
SHEET    6   B 8 VAL B 195  SER B 201  1  O  LYS B 196   N  ILE B 173
SHEET    7   B 8 ILE B 309  GLY B 314  1  O  ILE B 312   N  THR B 200
SHEET    8   B 8 LYS B 334  VAL B 339  1  O  LEU B 337   N  LEU B 311
CISPEP   1 GLY A  103    PRO A  104          0        -0.36
CISPEP   2 GLN A  141    PRO A  142          0        -0.03
CISPEP   3 SER A  305    PRO A  306          0         0.20
CISPEP   4 GLU A  332    PRO A  333          0         0.00
CISPEP   5 GLY B  103    PRO B  104          0        -0.23
CISPEP   6 GLN B  141    PRO B  142          0         0.27
CISPEP   7 SER B  305    PRO B  306          0         0.21
CISPEP   8 GLU B  332    PRO B  333          0         0.02
CRYST1   46.264  136.337   48.134  90.00 108.74  90.00 P 1 21 1      4
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.021615  0.000000  0.007333        0.00000
SCALE2      0.000000  0.007335  0.000000        0.00000
SCALE3      0.000000  0.000000  0.021938        0.00000
TER    2527      LEU A 367
TER    5029      LEU B 367
MASTER      375    0    0   23   16    0    0    6 5221    2    0   58
END