longtext: 2PL5-pdb

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HEADER    TRANSFERASE                             19-APR-07   2PL5
TITLE     CRYSTAL STRUCTURE OF HOMOSERINE O-ACETYLTRANSFERASE FROM
TITLE    2 LEPTOSPIRA INTERROGANS
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: HOMOSERINE O-ACETYLTRANSFERASE;
COMPND   3 CHAIN: A;
COMPND   4 SYNONYM: HOMOSERINE O-TRANS-ACETYLASE, HOMOSERINE
COMPND   5 TRANSACETYLASE, HTA;
COMPND   6 EC: 2.3.1.31;
COMPND   7 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: LEPTOSPIRA INTERROGANS;
SOURCE   3 ORGANISM_COMMON: BACTERIA;
SOURCE   4 GENE: METX;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_STRAIN: BL21;
SOURCE   7 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE   8 EXPRESSION_SYSTEM_PLASMID: PET22B
KEYWDS    HOMOSERINE O-ACETYLTRANSFERASE, ALPHA/BETA HYDROLASE
KEYWDS   2 SUPERFAMILY
EXPDTA    X-RAY DIFFRACTION
AUTHOR    L.LIU,M.WANG,Y.WANG,Z.WEI,H.XU,W.GONG
REVDAT   1   20-NOV-07 2PL5    0
JRNL        AUTH   M.WANG,L.LIU,Y.WANG,Z.WEI,P.ZHANG,Y.LI,X.JIANG,
JRNL        AUTH 2 H.XU,W.GONG
JRNL        TITL   CRYSTAL STRUCTURE OF HOMOSERINE
JRNL        TITL 2 O-ACETYLTRANSFERASE FROM LEPTOSPIRA INTERROGANS
JRNL        REF    BIOCHEM.BIOPHYS.RES.COMMUN.   V. 363  1050 2007
JRNL        REFN   ASTM BBRCA9  US ISSN 0006-291X
REMARK   1
REMARK   2
REMARK   2 RESOLUTION. 2.20 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.2.0019
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.20
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 50.00
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.7
REMARK   3   NUMBER OF REFLECTIONS             : 21656
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.218
REMARK   3   R VALUE            (WORKING SET) : 0.216
REMARK   3   FREE R VALUE                     : 0.258
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.100
REMARK   3   FREE R VALUE TEST SET COUNT      : 1108
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH           : 2.20
REMARK   3   BIN RESOLUTION RANGE LOW            : 2.26
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 1485
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 100.00
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2410
REMARK   3   BIN FREE R VALUE SET COUNT          : 78
REMARK   3   BIN FREE R VALUE                    : 0.3450
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   ALL ATOMS                : 3043
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 39.63
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : 0.27000
REMARK   3    B22 (A**2) : 0.27000
REMARK   3    B33 (A**2) : -0.54000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.290
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.222
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.161
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 6.205
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.942
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.930
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  2917 ; 0.008 ; 0.022
REMARK   3   BOND LENGTHS OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES):  3963 ; 1.059 ; 1.957
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):   378 ; 5.371 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   127 ;34.398 ;24.567
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):   476 ;14.843 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    11 ;17.390 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):   426 ; 0.074 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  2244 ; 0.003 ; 0.020
REMARK   3   GENERAL PLANES OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  1382 ; 0.183 ; 0.200
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  1977 ; 0.302 ; 0.200
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):   234 ; 0.145 ; 0.200
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):   106 ; 0.167 ; 0.200
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):    13 ; 0.165 ; 0.200
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  1881 ; 0.498 ; 1.500
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  2938 ; 0.882 ; 2.000
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  1194 ; 1.065 ; 3.000
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  1019 ; 1.559 ; 4.500
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : 0
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 0
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE
REMARK   3  RIDING POSITIONS
REMARK   4
REMARK   4 2PL5 COMPLIES WITH FORMAT V. 3.1, 1-AUG-2007
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ.
REMARK 100 THE RCSB ID CODE IS RCSB042498.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 10-MAY-2005
REMARK 200  TEMPERATURE           (KELVIN) : 100.0
REMARK 200  PH                             : 6.50
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : N
REMARK 200  RADIATION SOURCE               : ROTATING ANODE
REMARK 200  BEAMLINE                       : NULL
REMARK 200  X-RAY GENERATOR MODEL          : RIGAKU
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.5418
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : AREA DETECTOR
REMARK 200  DETECTOR MANUFACTURER          : RIGAKU RAXIS IV
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 21812
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.200
REMARK 200  RESOLUTION RANGE LOW       (A) : 58.820
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.6
REMARK 200  DATA REDUNDANCY                : NULL
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : NULL
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.20
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.28
REMARK 200  COMPLETENESS FOR SHELL     (%) : 100.0
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: SAD
REMARK 200 SOFTWARE USED: SHELXD
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 50.82
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.50
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 10% PEG 20000, 0.1M MES, PH 6.5,
REMARK 280  VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 43 21 2
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,-Y,1/2+Z
REMARK 290       3555   1/2-Y,1/2+X,3/4+Z
REMARK 290       4555   1/2+Y,1/2-X,1/4+Z
REMARK 290       5555   1/2-X,1/2+Y,3/4-Z
REMARK 290       6555   1/2+X,1/2-Y,1/4-Z
REMARK 290       7555   Y,X,-Z
REMARK 290       8555   -Y,-X,1/2-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000      107.57150
REMARK 290   SMTRY1   3  0.000000 -1.000000  0.000000       30.56200
REMARK 290   SMTRY2   3  1.000000  0.000000  0.000000       30.56200
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000      161.35725
REMARK 290   SMTRY1   4  0.000000  1.000000  0.000000       30.56200
REMARK 290   SMTRY2   4 -1.000000  0.000000  0.000000       30.56200
REMARK 290   SMTRY3   4  0.000000  0.000000  1.000000       53.78575
REMARK 290   SMTRY1   5 -1.000000  0.000000  0.000000       30.56200
REMARK 290   SMTRY2   5  0.000000  1.000000  0.000000       30.56200
REMARK 290   SMTRY3   5  0.000000  0.000000 -1.000000      161.35725
REMARK 290   SMTRY1   6  1.000000  0.000000  0.000000       30.56200
REMARK 290   SMTRY2   6  0.000000 -1.000000  0.000000       30.56200
REMARK 290   SMTRY3   6  0.000000  0.000000 -1.000000       53.78575
REMARK 290   SMTRY1   7  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY2   7  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   7  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   8  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY2   8 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   8  0.000000  0.000000 -1.000000      107.57150
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMER
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350   BIOMT1   2  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT2   2  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT3   2  0.000000  0.000000 -1.000000      215.14300
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C  SSEQI
REMARK 465     MET A     1
REMARK 465     ASN A     2
REMARK 465     GLU A     3
REMARK 465     THR A     4
REMARK 480
REMARK 480 ZERO OCCUPANCY ATOM
REMARK 480 THE FOLLOWING RESIDUES HAVE ATOMS MODELED WITH ZERO
REMARK 480 OCCUPANCY. THE LOCATION AND PROPERTIES OF THESE ATOMS
REMARK 480 MAY NOT BE RELIABLE. (M=MODEL NUMBER; RES=RESIDUE NAME;
REMARK 480 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 480   M RES C SSEQI ATOMS
REMARK 480     LYS A   70   CG    CD    CE    NZ
REMARK 480     LYS A   71   CG    CD    CE    NZ
REMARK 480     LYS A  290   CG    CD    CE    NZ
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI
REMARK 500   CE1  TYR A   228     OD1  ASP A   345              1.53
REMARK 500   CE1  TYR A   228     CG   ASP A   345              2.19
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    PRO A  72     -162.68    -78.01
REMARK 500    SER A 153     -118.48     65.02
REMARK 500    ASN A 205       18.39     53.66
REMARK 500    LEU A 207       30.38    -99.39
REMARK 500    ASP A 209      -54.10   -151.72
REMARK 500    VAL A 254       54.71    -91.82
REMARK 500    ASP A 267       96.33    -60.86
REMARK 500    TYR A 314       77.74   -118.55
REMARK 500    HIS A 344      -38.97   -166.69
REMARK 500    ASP A 345       40.00    -97.38
REMARK 500
REMARK 500 REMARK: NULL
DBREF  2PL5 A    1   366  UNP    Q8F4I0   METX_LEPIN       1    366
SEQRES   1 A  366  MET ASN GLU THR GLY SER ILE GLY ILE ILE GLU THR LYS
SEQRES   2 A  366  TYR ALA GLU PHE LYS GLU LEU ILE LEU ASN ASN GLY SER
SEQRES   3 A  366  VAL LEU SER PRO VAL VAL ILE ALA TYR GLU THR TYR GLY
SEQRES   4 A  366  THR LEU SER SER SER LYS ASN ASN ALA ILE LEU ILE CYS
SEQRES   5 A  366  HIS ALA LEU SER GLY ASP ALA HIS ALA ALA GLY TYR HIS
SEQRES   6 A  366  SER GLY SER ASP LYS LYS PRO GLY TRP TRP ASP ASP TYR
SEQRES   7 A  366  ILE GLY PRO GLY LYS SER PHE ASP THR ASN GLN TYR PHE
SEQRES   8 A  366  ILE ILE CYS SER ASN VAL ILE GLY GLY CYS LYS GLY SER
SEQRES   9 A  366  SER GLY PRO LEU SER ILE HIS PRO GLU THR SER THR PRO
SEQRES  10 A  366  TYR GLY SER ARG PHE PRO PHE VAL SER ILE GLN ASP MET
SEQRES  11 A  366  VAL LYS ALA GLN LYS LEU LEU VAL GLU SER LEU GLY ILE
SEQRES  12 A  366  GLU LYS LEU PHE CYS VAL ALA GLY GLY SER MET GLY GLY
SEQRES  13 A  366  MET GLN ALA LEU GLU TRP SER ILE ALA TYR PRO ASN SER
SEQRES  14 A  366  LEU SER ASN CYS ILE VAL MET ALA SER THR ALA GLU HIS
SEQRES  15 A  366  SER ALA MET GLN ILE ALA PHE ASN GLU VAL GLY ARG GLN
SEQRES  16 A  366  ALA ILE LEU SER ASP PRO ASN TRP LYS ASN GLY LEU TYR
SEQRES  17 A  366  ASP GLU ASN SER PRO ARG LYS GLY LEU ALA LEU ALA ARG
SEQRES  18 A  366  MET VAL GLY HIS ILE THR TYR LEU SER ASP ASP LYS MET
SEQRES  19 A  366  ARG GLU LYS PHE GLY ARG ASN PRO PRO ARG GLY ASN ILE
SEQRES  20 A  366  LEU SER THR ASP PHE ALA VAL GLY SER TYR LEU ILE TYR
SEQRES  21 A  366  GLN GLY GLU SER PHE VAL ASP ARG PHE ASP ALA ASN SER
SEQRES  22 A  366  TYR ILE TYR VAL THR LYS ALA LEU ASP HIS TYR SER LEU
SEQRES  23 A  366  GLY LYS GLY LYS GLU LEU THR ALA ALA LEU SER ASN ALA
SEQRES  24 A  366  THR CYS ARG PHE LEU VAL VAL SER TYR SER SER ASP TRP
SEQRES  25 A  366  LEU TYR PRO PRO ALA GLN SER ARG GLU ILE VAL LYS SER
SEQRES  26 A  366  LEU GLU ALA ALA ASP LYS ARG VAL PHE TYR VAL GLU LEU
SEQRES  27 A  366  GLN SER GLY GLU GLY HIS ASP SER PHE LEU LEU LYS ASN
SEQRES  28 A  366  PRO LYS GLN ILE GLU ILE LEU LYS GLY PHE LEU GLU ASN
SEQRES  29 A  366  PRO ASN
HET    GOL  A 400       6
HET    GOL  A 500       6
HETNAM     GOL GLYCEROL
FORMUL   2  GOL    2(C3 H8 O3)
FORMUL   4  HOH   *188(H2 O)
HELIX    1   1 TYR A  118  PHE A  122  5                                   5
HELIX    2   2 SER A  126  LEU A  141  1                                  16
HELIX    3   3 SER A  153  TYR A  166  1                                  14
HELIX    4   4 SER A  183  SER A  199  1                                  17
HELIX    5   5 TRP A  203  LEU A  207  5                                   5
HELIX    6   6 PRO A  213  THR A  227  1                                  15
HELIX    7   7 SER A  230  GLY A  239  1                                  10
HELIX    8   8 GLY A  255  TYR A  260  5                                   6
HELIX    9   9 ASP A  270  TYR A  284  1                                  15
HELIX   10  10 LYS A  288  SER A  297  1                                  10
HELIX   11  11 PRO A  315  ALA A  329  1                                  15
HELIX   12  12 HIS A  344  LEU A  349  5                                   6
HELIX   13  13 ASN A  351  ASN A  364  1                                  14
SHEET    1   A 8 LYS A  13  PHE A  17  0
SHEET    2   A 8 VAL A  31  GLY A  39 -1  O  TYR A  35   N  LYS A  13
SHEET    3   A 8 PHE A  91  SER A  95 -1  O  ILE A  92   N  TYR A  38
SHEET    4   A 8 ALA A  48  CYS A  52  1  N  ILE A  51   O  ILE A  93
SHEET    5   A 8 LEU A 146  GLY A 152  1  O  ALA A 150   N  CYS A  52
SHEET    6   A 8 LEU A 170  MET A 176  1  O  ILE A 174   N  VAL A 149
SHEET    7   A 8 ARG A 302  TYR A 308  1  O  LEU A 304   N  VAL A 175
SHEET    8   A 8 VAL A 333  LEU A 338  1  O  LEU A 338   N  SER A 307
SHEET    1   B 2 LEU A  20  ILE A  21  0
SHEET    2   B 2 VAL A  27  LEU A  28 -1  O  LEU A  28   N  LEU A  20
SHEET    1   C 2 ILE A  79  GLY A  80  0
SHEET    2   C 2 PHE A  85  ASP A  86  1  O  PHE A  85   N  GLY A  80
CISPEP   1 SER A   29    PRO A   30          0        -1.61
CRYST1   61.124   61.124  215.143  90.00  90.00  90.00 P 43 21 2     8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.016360  0.000000  0.000000        0.00000
SCALE2      0.000000  0.016360  0.000000        0.00000
SCALE3      0.000000  0.000000  0.004648        0.00000
TER    2844      ASN A 366
MASTER      304    0    2   13   12    0    0    6 3043    1   12   29
END