longtext: 2QR5-pdb

content
HEADER    HYDROLASE                               27-JUL-07   2QR5
TITLE     AEROPYRUM PERNIX ACYLAMINOACYL PEPTIDASE, H367A MUTANT
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: ACYLAMINO-ACID-RELEASING ENZYME;
COMPND   3 CHAIN: A, B;
COMPND   4 SYNONYM: ACYLAMINOACYL-PEPTIDASE; AARE; ACYL-PEPTIDE
COMPND   5 HYDROLASE; APH;
COMPND   6 EC: 3.4.19.1;
COMPND   7 ENGINEERED: YES;
COMPND   8 MUTATION: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: AEROPYRUM PERNIX;
SOURCE   3 ORGANISM_COMMON: ARCHAEA;
SOURCE   4 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   5 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE   6 EXPRESSION_SYSTEM_PLASMID: PET22B
KEYWDS    ACYLAMINOACYL PEPTIDASE, THERMOPHILIC ENZYME, OXYANION
KEYWDS   2 BINDING SITE, CATALYTIC ACTIVITY, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    V.HARMAT,A.PALLO,A.L.KISS,L.POLGAR
REVDAT   1   20-MAY-08 2QR5    0
JRNL        AUTH   A.L.KISS,A.PALLO,G.NARAY-SZABO,V.HARMAT,L.POLGAR
JRNL        TITL   STRUCTURAL AND KINETIC CONTRIBUTIONS OF THE
JRNL        TITL 2 OXYANION BINDING SITE TO THE CATALYTIC ACTIVITY OF
JRNL        TITL 3 ACYLAMINOACYL PEPTIDASE
JRNL        REF    J.STRUCT.BIOL.                V. 162   312 2008
JRNL        REFN   ASTM JSBIEM  US ISSN 1047-8477
REMARK   1
REMARK   2
REMARK   2 RESOLUTION. 2.20 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.2
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.20
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 19.69
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000
REMARK   3   COMPLETENESS FOR RANGE        (%) : 93.3
REMARK   3   NUMBER OF REFLECTIONS             : 55723
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.180
REMARK   3   R VALUE            (WORKING SET) : 0.177
REMARK   3   FREE R VALUE                     : 0.222
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.100
REMARK   3   FREE R VALUE TEST SET COUNT      : 2982
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH           : 2.20
REMARK   3   BIN RESOLUTION RANGE LOW            : 2.26
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 3921
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 90.95
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2590
REMARK   3   BIN FREE R VALUE SET COUNT          : 229
REMARK   3   BIN FREE R VALUE                    : 0.3420
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   ALL ATOMS                : 8861
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 38.14
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 35.78
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : 0.01000
REMARK   3    B22 (A**2) : 0.01000
REMARK   3    B33 (A**2) : -0.02000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.269
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.203
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.150
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 12.619
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.956
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.929
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  8866 ; 0.014 ; 0.022
REMARK   3   BOND LENGTHS OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 12030 ; 1.502 ; 1.975
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  1158 ; 6.954 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   356 ;35.370 ;22.697
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  1420 ;16.015 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    81 ;21.238 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  1346 ; 0.091 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  6746 ; 0.006 ; 0.020
REMARK   3   GENERAL PLANES OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  3726 ; 0.212 ; 0.200
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  6109 ; 0.314 ; 0.200
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):   468 ; 0.157 ; 0.200
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):    22 ; 0.109 ; 0.200
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):     7 ; 0.276 ; 0.200
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  5805 ; 1.592 ; 2.000
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  9125 ; 2.457 ; 3.000
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  3414 ; 2.052 ; 2.000
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  2901 ; 3.067 ; 3.000
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : 1
REMARK   3
REMARK   3  NCS GROUP NUMBER               : 1
REMARK   3     CHAIN NAMES                    : A B
REMARK   3     NUMBER OF COMPONENTS NCS GROUP : 13
REMARK   3       COMPONENT C  SSSEQI  TO  C   SSSEQI   CODE
REMARK   3           1     A      7       A      88      2
REMARK   3           1     B      7       B      88      2
REMARK   3           2     A     90       A     106      2
REMARK   3           2     B     90       B     106      2
REMARK   3           3     A    108       A     109      2
REMARK   3           3     B    108       B     109      2
REMARK   3           4     A    111       A     221      2
REMARK   3           4     B    111       B     221      2
REMARK   3           5     A    223       A     233      2
REMARK   3           5     B    223       B     233      2
REMARK   3           6     A    235       A     309      2
REMARK   3           6     B    235       B     309      2
REMARK   3           7     A    311       A     323      2
REMARK   3           7     B    311       B     323      2
REMARK   3           8     A    325       A     327      2
REMARK   3           8     B    325       B     327      2
REMARK   3           9     A    329       A     365      2
REMARK   3           9     B    329       B     365      2
REMARK   3          10     A    371       A     430      2
REMARK   3          10     B    371       B     430      2
REMARK   3          11     A    432       A     496      2
REMARK   3          11     B    432       B     496      2
REMARK   3          12     A    498       A     566      2
REMARK   3          12     B    498       B     566      2
REMARK   3          13     A    568       A     579      2
REMARK   3          13     B    568       B     579      2
REMARK   3                   GROUP CHAIN        COUNT   RMS     WEIGHT
REMARK   3   TIGHT POSITIONAL   1    A    (A):   2220 ;  0.05 ;  0.05
REMARK   3   MEDIUM POSITIONAL  1    A    (A):   1919 ;  0.14 ;  0.50
REMARK   3   TIGHT THERMAL      1    A (A**2):   2220 ;  0.26 ;  0.50
REMARK   3   MEDIUM THERMAL     1    A (A**2):   1919 ;  0.93 ;  2.00
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 2
REMARK   3
REMARK   3   TLS GROUP : 1
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A     6        A   581
REMARK   3    ORIGIN FOR THE GROUP (A):   2.5937  81.7629 -14.2593
REMARK   3    T TENSOR
REMARK   3      T11:  -0.0974 T22:  -0.0640
REMARK   3      T33:  -0.0451 T12:   0.0132
REMARK   3      T13:  -0.0033 T23:  -0.0041
REMARK   3    L TENSOR
REMARK   3      L11:   0.7834 L22:   0.3717
REMARK   3      L33:   1.5107 L12:   0.0246
REMARK   3      L13:   0.0111 L23:   0.0090
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0296 S12:   0.1545 S13:   0.0445
REMARK   3      S21:  -0.0321 S22:   0.0065 S23:   0.0012
REMARK   3      S31:  -0.0363 S32:  -0.0149 S33:   0.0230
REMARK   3
REMARK   3   TLS GROUP : 2
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   B     6        B   581
REMARK   3    ORIGIN FOR THE GROUP (A):   7.7446  88.1611  35.3097
REMARK   3    T TENSOR
REMARK   3      T11:  -0.0505 T22:  -0.1322
REMARK   3      T33:  -0.0558 T12:  -0.0256
REMARK   3      T13:   0.0001 T23:  -0.0257
REMARK   3    L TENSOR
REMARK   3      L11:   0.8490 L22:   0.7707
REMARK   3      L33:   1.1431 L12:   0.0005
REMARK   3      L13:   0.0040 L23:  -0.1619
REMARK   3    S TENSOR
REMARK   3      S11:   0.0125 S12:  -0.1391 S13:   0.0232
REMARK   3      S21:   0.1015 S22:  -0.0403 S23:  -0.0227
REMARK   3      S31:  -0.0951 S32:  -0.0334 S33:   0.0278
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : BABINET MODEL WITH MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.40
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE
REMARK   3  RIDING POSITIONS
REMARK   4
REMARK   4 2QR5 COMPLIES WITH FORMAT V. 3.1, 01-AUG-2007
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB.
REMARK 100 THE RCSB ID CODE IS RCSB043950.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 20-FEB-2006
REMARK 200  TEMPERATURE           (KELVIN) : 293.0
REMARK 200  PH                             : 6.35
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : N
REMARK 200  RADIATION SOURCE               : ROTATING ANODE
REMARK 200  BEAMLINE                       : NULL
REMARK 200  X-RAY GENERATOR MODEL          : RIGAKU RU200
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.5418
REMARK 200  MONOCHROMATOR                  : GRAPHITE
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : IMAGE PLATE
REMARK 200  DETECTOR MANUFACTURER          : RIGAKU RAXIS IIC
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : XSCALE
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 58729
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.200
REMARK 200  RESOLUTION RANGE LOW       (A) : 20.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : -3.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 93.2
REMARK 200  DATA REDUNDANCY                : 3.710
REMARK 200  R MERGE                    (I) : 0.11800
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 11.5000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.20
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.50
REMARK 200  COMPLETENESS FOR SHELL     (%) : 93.6
REMARK 200  DATA REDUNDANCY IN SHELL       : 3.42
REMARK 200  R MERGE FOR SHELL          (I) : 0.46700
REMARK 200  R SYM FOR SHELL            (I) : 0.46700
REMARK 200   FOR SHELL         : 3.610
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: MOLREP
REMARK 200 STARTING MODEL: PDB ENTRY 1VE6 (ONE MONOMER)
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 49.33
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.43
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 169 MM SODIUM ACETATE, 0.4 MM EDTA,
REMARK 280  2% PEG 4000 0.51% BETA-OCTYL-GLUCOSIDE, PH 6.35, VAPOR
REMARK 280  DIFFUSION, HANGING DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   1/2-X,-Y,1/2+Z
REMARK 290       3555   -X,1/2+Y,1/2-Z
REMARK 290       4555   1/2+X,1/2-Y,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       51.13500
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       57.01000
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       52.52000
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       57.01000
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       51.13500
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       52.52000
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 300
REMARK 300 REMARK: THE BIOLOGICAL ASSEMBLY IS A DIMER BUILT UP BY
REMARK 300 CHAINS A AND B OF THE ASYMMETRIC UNIT.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 2650 ANGSTROM**2
REMARK 350 TOTAL SURFACE AREA FOR THE COMPLEX: 38440 ANGSTROM**2
REMARK 350 GAIN IN SOLVENT FREE ENERGY: -18 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C  SSEQI
REMARK 465     MET A     1
REMARK 465     ARG A     2
REMARK 465     ILE A     3
REMARK 465     ILE A     4
REMARK 465     MET A     5
REMARK 465     ARG A   582
REMARK 465     MET B     1
REMARK 465     ARG B     2
REMARK 465     ILE B     3
REMARK 465     ILE B     4
REMARK 465     MET B     5
REMARK 465     ARG B   582
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS(M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     VAL A   7    CG1   CG2
REMARK 470     ASP A  32    OD1   OD2
REMARK 470     GLU A  55    CD    OE1   OE2
REMARK 470     ARG A  61    NH2
REMARK 470     LYS A  85    NZ
REMARK 470     LYS A  94    NZ
REMARK 470     ASN A  96    CG    OD1   ND2
REMARK 470     ARG A  99    NH1   NH2
REMARK 470     GLU A 131    CD    OE1   OE2
REMARK 470     ARG A 174    NE    CZ    NH1   NH2
REMARK 470     ARG A 216    CD    NE    CZ    NH1   NH2
REMARK 470     GLU A 217    CD    OE1   OE2
REMARK 470     LYS A 238    NZ
REMARK 470     ARG A 244    NE    CZ    NH1   NH2
REMARK 470     ARG A 327    NH1   NH2
REMARK 470     ARG A 345    NH1   NH2
REMARK 470     ASP A 510    OD1   OD2
REMARK 470     ILE A 567    CD1
REMARK 470     VAL B   7    CG1   CG2
REMARK 470     ARG B  11    CD    NE    CZ    NH1   NH2
REMARK 470     ASP B  32    OD1   OD2
REMARK 470     ASP B  34    CG    OD1   OD2
REMARK 470     ARG B  61    CZ    NH1   NH2
REMARK 470     LYS B  85    NZ
REMARK 470     LYS B  94    NZ
REMARK 470     ASN B  96    OD1   ND2
REMARK 470     ARG B  99    CZ    NH1   NH2
REMARK 470     GLU B 131    CG    CD    OE1   OE2
REMARK 470     ARG B 174    NH1   NH2
REMARK 470     ARG B 216    CG    CD    NE    CZ    NH1   NH2
REMARK 470     GLU B 217    CD    OE1   OE2
REMARK 470     GLU B 231    CG    CD    OE1   OE2
REMARK 470     LYS B 238    CD    CE    NZ
REMARK 470     ARG B 327    CZ    NH1   NH2
REMARK 470     ARG B 328    CZ    NH1   NH2
REMARK 470     ARG B 345    CZ    NH1   NH2
REMARK 470     GLU B 479    CD    OE1   OE2
REMARK 470     ILE B 567    CD1
REMARK 470     GLU B 580    CG    CD    OE1   OE2
REMARK 470     ARG B 581    CG    CD    NE    CZ    NH1   NH2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCELIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    GLY B  33   N   -  CA  -  C   ANGL. DEV. = -24.8 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    VAL A   7       80.81     21.18
REMARK 500    ASP A  32       46.08     29.49
REMARK 500    ASP A  34       35.41   -141.67
REMARK 500    ARG A  61      -86.92    -84.13
REMARK 500    SER A  66     -179.37   -170.89
REMARK 500    THR A 130     -168.50   -116.10
REMARK 500    ASP A 140     -161.79   -126.47
REMARK 500    ASP A 414       48.74   -140.78
REMARK 500    SER A 445     -126.45     66.17
REMARK 500    ASP B  32       42.22     21.83
REMARK 500    ARG B  61      -84.58    -84.45
REMARK 500    ASP B 140     -161.88   -122.36
REMARK 500    ASP B 158      148.17   -170.06
REMARK 500    THR B 214     -169.98   -103.74
REMARK 500    ASP B 414       53.30   -143.30
REMARK 500    SER B 445     -120.05     59.31
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500                                 MODEL     OMEGA
REMARK 500 PRO A    6    VAL A    7                   66.02
REMARK 500 GLY A   53    GLY A   54                   65.39
REMARK 500 GLY A   54    GLU A   55                  149.32
REMARK 500 ASP B   32    GLY B   33                   69.84
REMARK 500
REMARK 500 REMARK: NULL
DBREF  2QR5 A    1   582  UNP    Q9YBQ2   APEH_AERPE       1    582
DBREF  2QR5 B    1   582  UNP    Q9YBQ2   APEH_AERPE       1    582
SEQADV 2QR5 ALA A  367  UNP  Q9YBQ2    HIS   367 ENGINEERED
SEQADV 2QR5 ALA B  367  UNP  Q9YBQ2    HIS   367 ENGINEERED
SEQRES   1 A  582  MET ARG ILE ILE MET PRO VAL GLU PHE SER ARG ILE VAL
SEQRES   2 A  582  ARG ASP VAL GLU ARG LEU ILE ALA VAL GLU LYS TYR SER
SEQRES   3 A  582  LEU GLN GLY VAL VAL ASP GLY ASP LYS LEU LEU VAL VAL
SEQRES   4 A  582  GLY PHE SER GLU GLY SER VAL ASN ALA TYR LEU TYR ASP
SEQRES   5 A  582  GLY GLY GLU THR VAL LYS LEU ASN ARG GLU PRO ILE ASN
SEQRES   6 A  582  SER VAL LEU ASP PRO HIS TYR GLY VAL GLY ARG VAL ILE
SEQRES   7 A  582  LEU VAL ARG ASP VAL SER LYS GLY ALA GLU GLN HIS ALA
SEQRES   8 A  582  LEU PHE LYS VAL ASN THR SER ARG PRO GLY GLU GLU GLN
SEQRES   9 A  582  ARG LEU GLU ALA VAL LYS PRO MET ARG ILE LEU SER GLY
SEQRES  10 A  582  VAL ASP THR GLY GLU ALA VAL VAL PHE THR GLY ALA THR
SEQRES  11 A  582  GLU ASP ARG VAL ALA LEU TYR ALA LEU ASP GLY GLY GLY
SEQRES  12 A  582  LEU ARG GLU LEU ALA ARG LEU PRO GLY PHE GLY PHE VAL
SEQRES  13 A  582  SER ASP ILE ARG GLY ASP LEU ILE ALA GLY LEU GLY PHE
SEQRES  14 A  582  PHE GLY GLY GLY ARG VAL SER LEU PHE THR SER ASN LEU
SEQRES  15 A  582  SER SER GLY GLY LEU ARG VAL PHE ASP SER GLY GLU GLY
SEQRES  16 A  582  SER PHE SER SER ALA SER ILE SER PRO GLY MET LYS VAL
SEQRES  17 A  582  THR ALA GLY LEU GLU THR ALA ARG GLU ALA ARG LEU VAL
SEQRES  18 A  582  THR VAL ASP PRO ARG ASP GLY SER VAL GLU ASP LEU GLU
SEQRES  19 A  582  LEU PRO SER LYS ASP PHE SER SER TYR ARG PRO THR ALA
SEQRES  20 A  582  ILE THR TRP LEU GLY TYR LEU PRO ASP GLY ARG LEU ALA
SEQRES  21 A  582  VAL VAL ALA ARG ARG GLU GLY ARG SER ALA VAL PHE ILE
SEQRES  22 A  582  ASP GLY GLU ARG VAL GLU ALA PRO GLN GLY ASN HIS GLY
SEQRES  23 A  582  ARG VAL VAL LEU TRP ARG GLY LYS LEU VAL THR SER HIS
SEQRES  24 A  582  THR SER LEU SER THR PRO PRO ARG ILE VAL SER LEU PRO
SEQRES  25 A  582  SER GLY GLU PRO LEU LEU GLU GLY GLY LEU PRO GLU ASP
SEQRES  26 A  582  LEU ARG ARG SER ILE ALA GLY SER ARG LEU VAL TRP VAL
SEQRES  27 A  582  GLU SER PHE ASP GLY SER ARG VAL PRO THR TYR VAL LEU
SEQRES  28 A  582  GLU SER GLY ARG ALA PRO THR PRO GLY PRO THR VAL VAL
SEQRES  29 A  582  LEU VAL ALA GLY GLY PRO PHE ALA GLU ASP SER ASP SER
SEQRES  30 A  582  TRP ASP THR PHE ALA ALA SER LEU ALA ALA ALA GLY PHE
SEQRES  31 A  582  HIS VAL VAL MET PRO ASN TYR ARG GLY SER THR GLY TYR
SEQRES  32 A  582  GLY GLU GLU TRP ARG LEU LYS ILE ILE GLY ASP PRO CYS
SEQRES  33 A  582  GLY GLY GLU LEU GLU ASP VAL SER ALA ALA ALA ARG TRP
SEQRES  34 A  582  ALA ARG GLU SER GLY LEU ALA SER GLU LEU TYR ILE MET
SEQRES  35 A  582  GLY TYR SER TYR GLY GLY TYR MET THR LEU CYS ALA LEU
SEQRES  36 A  582  THR MET LYS PRO GLY LEU PHE LYS ALA GLY VAL ALA GLY
SEQRES  37 A  582  ALA SER VAL VAL ASP TRP GLU GLU MET TYR GLU LEU SER
SEQRES  38 A  582  ASP ALA ALA PHE ARG ASN PHE ILE GLU GLN LEU THR GLY
SEQRES  39 A  582  GLY SER ARG GLU ILE MET ARG SER ARG SER PRO ILE ASN
SEQRES  40 A  582  HIS VAL ASP ARG ILE LYS GLU PRO LEU ALA LEU ILE HIS
SEQRES  41 A  582  PRO GLN ASN ASP SER ARG THR PRO LEU LYS PRO LEU LEU
SEQRES  42 A  582  ARG LEU MET GLY GLU LEU LEU ALA ARG GLY LYS THR PHE
SEQRES  43 A  582  GLU ALA HIS ILE ILE PRO ASP ALA GLY HIS ALA ILE ASN
SEQRES  44 A  582  THR MET GLU ASP ALA VAL LYS ILE LEU LEU PRO ALA VAL
SEQRES  45 A  582  PHE PHE LEU ALA THR GLN ARG GLU ARG ARG
SEQRES   1 B  582  MET ARG ILE ILE MET PRO VAL GLU PHE SER ARG ILE VAL
SEQRES   2 B  582  ARG ASP VAL GLU ARG LEU ILE ALA VAL GLU LYS TYR SER
SEQRES   3 B  582  LEU GLN GLY VAL VAL ASP GLY ASP LYS LEU LEU VAL VAL
SEQRES   4 B  582  GLY PHE SER GLU GLY SER VAL ASN ALA TYR LEU TYR ASP
SEQRES   5 B  582  GLY GLY GLU THR VAL LYS LEU ASN ARG GLU PRO ILE ASN
SEQRES   6 B  582  SER VAL LEU ASP PRO HIS TYR GLY VAL GLY ARG VAL ILE
SEQRES   7 B  582  LEU VAL ARG ASP VAL SER LYS GLY ALA GLU GLN HIS ALA
SEQRES   8 B  582  LEU PHE LYS VAL ASN THR SER ARG PRO GLY GLU GLU GLN
SEQRES   9 B  582  ARG LEU GLU ALA VAL LYS PRO MET ARG ILE LEU SER GLY
SEQRES  10 B  582  VAL ASP THR GLY GLU ALA VAL VAL PHE THR GLY ALA THR
SEQRES  11 B  582  GLU ASP ARG VAL ALA LEU TYR ALA LEU ASP GLY GLY GLY
SEQRES  12 B  582  LEU ARG GLU LEU ALA ARG LEU PRO GLY PHE GLY PHE VAL
SEQRES  13 B  582  SER ASP ILE ARG GLY ASP LEU ILE ALA GLY LEU GLY PHE
SEQRES  14 B  582  PHE GLY GLY GLY ARG VAL SER LEU PHE THR SER ASN LEU
SEQRES  15 B  582  SER SER GLY GLY LEU ARG VAL PHE ASP SER GLY GLU GLY
SEQRES  16 B  582  SER PHE SER SER ALA SER ILE SER PRO GLY MET LYS VAL
SEQRES  17 B  582  THR ALA GLY LEU GLU THR ALA ARG GLU ALA ARG LEU VAL
SEQRES  18 B  582  THR VAL ASP PRO ARG ASP GLY SER VAL GLU ASP LEU GLU
SEQRES  19 B  582  LEU PRO SER LYS ASP PHE SER SER TYR ARG PRO THR ALA
SEQRES  20 B  582  ILE THR TRP LEU GLY TYR LEU PRO ASP GLY ARG LEU ALA
SEQRES  21 B  582  VAL VAL ALA ARG ARG GLU GLY ARG SER ALA VAL PHE ILE
SEQRES  22 B  582  ASP GLY GLU ARG VAL GLU ALA PRO GLN GLY ASN HIS GLY
SEQRES  23 B  582  ARG VAL VAL LEU TRP ARG GLY LYS LEU VAL THR SER HIS
SEQRES  24 B  582  THR SER LEU SER THR PRO PRO ARG ILE VAL SER LEU PRO
SEQRES  25 B  582  SER GLY GLU PRO LEU LEU GLU GLY GLY LEU PRO GLU ASP
SEQRES  26 B  582  LEU ARG ARG SER ILE ALA GLY SER ARG LEU VAL TRP VAL
SEQRES  27 B  582  GLU SER PHE ASP GLY SER ARG VAL PRO THR TYR VAL LEU
SEQRES  28 B  582  GLU SER GLY ARG ALA PRO THR PRO GLY PRO THR VAL VAL
SEQRES  29 B  582  LEU VAL ALA GLY GLY PRO PHE ALA GLU ASP SER ASP SER
SEQRES  30 B  582  TRP ASP THR PHE ALA ALA SER LEU ALA ALA ALA GLY PHE
SEQRES  31 B  582  HIS VAL VAL MET PRO ASN TYR ARG GLY SER THR GLY TYR
SEQRES  32 B  582  GLY GLU GLU TRP ARG LEU LYS ILE ILE GLY ASP PRO CYS
SEQRES  33 B  582  GLY GLY GLU LEU GLU ASP VAL SER ALA ALA ALA ARG TRP
SEQRES  34 B  582  ALA ARG GLU SER GLY LEU ALA SER GLU LEU TYR ILE MET
SEQRES  35 B  582  GLY TYR SER TYR GLY GLY TYR MET THR LEU CYS ALA LEU
SEQRES  36 B  582  THR MET LYS PRO GLY LEU PHE LYS ALA GLY VAL ALA GLY
SEQRES  37 B  582  ALA SER VAL VAL ASP TRP GLU GLU MET TYR GLU LEU SER
SEQRES  38 B  582  ASP ALA ALA PHE ARG ASN PHE ILE GLU GLN LEU THR GLY
SEQRES  39 B  582  GLY SER ARG GLU ILE MET ARG SER ARG SER PRO ILE ASN
SEQRES  40 B  582  HIS VAL ASP ARG ILE LYS GLU PRO LEU ALA LEU ILE HIS
SEQRES  41 B  582  PRO GLN ASN ASP SER ARG THR PRO LEU LYS PRO LEU LEU
SEQRES  42 B  582  ARG LEU MET GLY GLU LEU LEU ALA ARG GLY LYS THR PHE
SEQRES  43 B  582  GLU ALA HIS ILE ILE PRO ASP ALA GLY HIS ALA ILE ASN
SEQRES  44 B  582  THR MET GLU ASP ALA VAL LYS ILE LEU LEU PRO ALA VAL
SEQRES  45 B  582  PHE PHE LEU ALA THR GLN ARG GLU ARG ARG
FORMUL   3  HOH   *183(H2 O)
HELIX    1   1 GLU A    8  VAL A   22  1                                  15
HELIX    2   2 LYS A  238  ARG A  244  1                                   7
HELIX    3   3 PRO A  323  ARG A  328  1                                   6
HELIX    4   4 ASP A  379  ALA A  388  1                                  10
HELIX    5   5 GLY A  404  LYS A  410  1                                   7
HELIX    6   6 GLY A  417  SER A  433  1                                  17
HELIX    7   7 SER A  445  LYS A  458  1                                  14
HELIX    8   8 ASP A  473  SER A  481  1                                   9
HELIX    9   9 ASP A  482  GLY A  494  1                                  13
HELIX   10  10 SER A  496  ARG A  503  1                                   8
HELIX   11  11 SER A  504  ILE A  512  5                                   9
HELIX   12  12 LEU A  529  ARG A  542  1                                  14
HELIX   13  13 THR A  560  ARG A  581  1                                  22
HELIX   14  14 GLU B    8  VAL B   22  1                                  15
HELIX   15  15 LYS B  238  ARG B  244  1                                   7
HELIX   16  16 PRO B  323  SER B  329  1                                   7
HELIX   17  17 ASP B  379  ALA B  388  1                                  10
HELIX   18  18 GLY B  404  LYS B  410  1                                   7
HELIX   19  19 GLY B  417  SER B  433  1                                  17
HELIX   20  20 SER B  445  LYS B  458  1                                  14
HELIX   21  21 ASP B  473  SER B  481  1                                   9
HELIX   22  22 ASP B  482  GLY B  494  1                                  13
HELIX   23  23 SER B  496  ARG B  503  1                                   8
HELIX   24  24 SER B  504  ILE B  512  5                                   9
HELIX   25  25 LEU B  529  ARG B  542  1                                  14
HELIX   26  26 THR B  560  GLU B  580  1                                  21
SHEET    1   A 4 LYS A  24  VAL A  31  0
SHEET    2   A 4 LYS A  35  SER A  42 -1  O  VAL A  39   N  SER A  26
SHEET    3   A 4 SER A  45  TYR A  51 -1  O  TYR A  49   N  VAL A  38
SHEET    4   A 4 THR A  56  LYS A  58 -1  O  VAL A  57   N  LEU A  50
SHEET    1   B 4 SER A  66  VAL A  67  0
SHEET    2   B 4 ARG A  76  ASP A  82 -1  O  VAL A  80   N  SER A  66
SHEET    3   B 4 HIS A  90  ASN A  96 -1  O  PHE A  93   N  LEU A  79
SHEET    4   B 4 GLU A 103  ARG A 105 -1  O  GLN A 104   N  LYS A  94
SHEET    1   C 5 ASP A  69  PRO A  70  0
SHEET    2   C 5 ARG A 113  ASP A 119  1  O  ASP A 119   N  ASP A  69
SHEET    3   C 5 VAL A 124  ALA A 129 -1  O  VAL A 125   N  VAL A 118
SHEET    4   C 5 VAL A 134  ASP A 140 -1  O  LEU A 139   N  VAL A 124
SHEET    5   C 5 GLY A 143  LEU A 150 -1  O  ALA A 148   N  LEU A 136
SHEET    1   D 4 GLY A 154  ARG A 160  0
SHEET    2   D 4 LEU A 163  GLY A 171 -1  O  ALA A 165   N  ASP A 158
SHEET    3   D 4 ARG A 174  ASN A 181 -1  O  SER A 176   N  GLY A 168
SHEET    4   D 4 ARG A 188  PHE A 190 -1  O  PHE A 190   N  LEU A 177
SHEET    1   E 4 GLY A 195  ILE A 202  0
SHEET    2   E 4 VAL A 208  THR A 214 -1  O  GLU A 213   N  SER A 196
SHEET    3   E 4 ALA A 218  VAL A 223 -1  O  ARG A 219   N  LEU A 212
SHEET    4   E 4 VAL A 230  ASP A 232 -1  O  GLU A 231   N  THR A 222
SHEET    1   F 4 ALA A 247  TYR A 253  0
SHEET    2   F 4 LEU A 259  ARG A 265 -1  O  VAL A 262   N  TRP A 250
SHEET    3   F 4 ARG A 268  ILE A 273 -1  O  PHE A 272   N  VAL A 261
SHEET    4   F 4 GLU A 276  VAL A 278 -1  O  VAL A 278   N  VAL A 271
SHEET    1   G 4 ASN A 284  TRP A 291  0
SHEET    2   G 4 LYS A 294  SER A 301 -1  O  LYS A 294   N  TRP A 291
SHEET    3   G 4 THR A 304  LEU A 311 -1  O  LEU A 311   N  LEU A 295
SHEET    4   G 4 GLU A 315  LEU A 318 -1  O  LEU A 317   N  ILE A 308
SHEET    1   H16 ILE A 330  GLU A 339  0
SHEET    2   H16 ARG A 345  SER A 353 -1  O  VAL A 346   N  VAL A 338
SHEET    3   H16 HIS A 391  PRO A 395 -1  O  MET A 394   N  TYR A 349
SHEET    4   H16 GLY A 360  ALA A 367  1  N  VAL A 363   O  HIS A 391
SHEET    5   H16 ALA A 436  TYR A 444  1  O  TYR A 440   N  VAL A 364
SHEET    6   H16 GLY A 465  GLY A 468  1  O  GLY A 468   N  GLY A 443
SHEET    7   H16 LEU A 516  PRO A 521  1  O  ALA A 517   N  ALA A 467
SHEET    8   H16 PHE A 546  ILE A 551  1  O  GLU A 547   N  LEU A 518
SHEET    9   H16 PHE B 546  ILE B 551 -1  O  ILE B 550   N  ALA A 548
SHEET   10   H16 LEU B 516  PRO B 521  1  N  LEU B 518   O  GLU B 547
SHEET   11   H16 GLY B 465  GLY B 468  1  N  ALA B 467   O  ALA B 517
SHEET   12   H16 ALA B 436  TYR B 444  1  N  GLY B 443   O  GLY B 468
SHEET   13   H16 GLY B 360  ALA B 367  1  N  VAL B 364   O  TYR B 440
SHEET   14   H16 HIS B 391  PRO B 395  1  O  HIS B 391   N  VAL B 363
SHEET   15   H16 ARG B 345  SER B 353 -1  N  TYR B 349   O  MET B 394
SHEET   16   H16 ILE B 330  GLU B 339 -1  N  VAL B 338   O  VAL B 346
SHEET    1   I 4 LYS B  24  VAL B  31  0
SHEET    2   I 4 LYS B  35  SER B  42 -1  O  LEU B  37   N  GLN B  28
SHEET    3   I 4 SER B  45  TYR B  51 -1  O  TYR B  49   N  VAL B  38
SHEET    4   I 4 THR B  56  LYS B  58 -1  O  VAL B  57   N  LEU B  50
SHEET    1   J 4 SER B  66  VAL B  67  0
SHEET    2   J 4 ARG B  76  ASP B  82 -1  O  VAL B  80   N  SER B  66
SHEET    3   J 4 HIS B  90  ASN B  96 -1  O  PHE B  93   N  LEU B  79
SHEET    4   J 4 GLU B 103  ARG B 105 -1  O  GLN B 104   N  LYS B  94
SHEET    1   K 5 ASP B  69  PRO B  70  0
SHEET    2   K 5 ARG B 113  ASP B 119  1  O  GLY B 117   N  ASP B  69
SHEET    3   K 5 VAL B 124  ALA B 129 -1  O  VAL B 125   N  VAL B 118
SHEET    4   K 5 VAL B 134  ASP B 140 -1  O  TYR B 137   N  PHE B 126
SHEET    5   K 5 GLY B 143  LEU B 150 -1  O  LEU B 150   N  VAL B 134
SHEET    1   L 4 GLY B 154  ARG B 160  0
SHEET    2   L 4 LEU B 163  GLY B 171 -1  O  ALA B 165   N  SER B 157
SHEET    3   L 4 ARG B 174  ASN B 181 -1  O  SER B 176   N  GLY B 168
SHEET    4   L 4 ARG B 188  PHE B 190 -1  O  PHE B 190   N  LEU B 177
SHEET    1   M 4 GLY B 195  ILE B 202  0
SHEET    2   M 4 VAL B 208  THR B 214 -1  O  GLU B 213   N  SER B 196
SHEET    3   M 4 ALA B 218  VAL B 223 -1  O  ARG B 219   N  LEU B 212
SHEET    4   M 4 VAL B 230  ASP B 232 -1  O  GLU B 231   N  THR B 222
SHEET    1   N 4 ALA B 247  TYR B 253  0
SHEET    2   N 4 LEU B 259  ARG B 265 -1  O  VAL B 262   N  TRP B 250
SHEET    3   N 4 ARG B 268  ILE B 273 -1  O  PHE B 272   N  VAL B 261
SHEET    4   N 4 GLU B 276  VAL B 278 -1  O  VAL B 278   N  VAL B 271
SHEET    1   O 4 ASN B 284  TRP B 291  0
SHEET    2   O 4 LYS B 294  SER B 301 -1  O  THR B 300   N  ASN B 284
SHEET    3   O 4 THR B 304  LEU B 311 -1  O  LEU B 311   N  LEU B 295
SHEET    4   O 4 GLU B 315  LEU B 318 -1  O  LEU B 317   N  ILE B 308
CISPEP   1 LEU A  311    PRO A  312          0         0.99
CISPEP   2 THR A  358    PRO A  359          0         3.47
CISPEP   3 GLY A  369    PRO A  370          0        -8.83
CISPEP   4 LEU B  311    PRO B  312          0         2.19
CISPEP   5 THR B  358    PRO B  359          0         1.44
CISPEP   6 GLY B  369    PRO B  370          0       -10.61
CRYST1  102.270  105.040  114.020  90.00  90.00  90.00 P 21 21 21    8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.009778  0.000000  0.000000        0.00000
SCALE2      0.000000  0.009520  0.000000        0.00000
SCALE3      0.000000  0.000000  0.008770        0.00000
TER    4357      ARG A 581
TER    8680      ARG B 581
MASTER      439    0    0   26   74    0    0    6 8861    2    0   90
END