longtext: 2QXT-pdb

content
HEADER    HYDROLASE                               13-AUG-07   2QXT
TITLE     CRYSTAL STRUCTURE ANALYSIS OF THE BACILLUS SUBTILIS LIPASE
TITLE    2 CRYSTALLIZED AT PH 4.5
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: LIPASE;
COMPND   3 CHAIN: A, B;
COMPND   4 SYNONYM: TRIACYLGLYCEROL LIPASE;
COMPND   5 EC: 3.1.1.3;
COMPND   6 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;
SOURCE   3 GENE: LIPA;
SOURCE   4 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   5 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);
SOURCE   6 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE   7 EXPRESSION_SYSTEM_PLASMID: PET-21B
KEYWDS    ALPHA/BETA HYDROLASE FOLD, LIPID DEGRADATION, SECRETED,
KEYWDS   2 HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    E.RAJAKUMARA,R.SANKARANARAYANAN
REVDAT   1   18-DEC-07 2QXT    0
JRNL        AUTH   E.RAJAKUMARA,P.ACHARYA,S.AHMAD,R.SANKARANARYANAN,
JRNL        AUTH 2 N.M.RAO
JRNL        TITL   STRUCTURAL BASIS FOR THE REMARKABLE STABILITY OF
JRNL        TITL 2 BACILLUS SUBTILIS LIPASE (LIP A) AT LOW PH
JRNL        REF    BIOCHIM.BIOPHYS.ACTA                       2007
JRNL        REFN   ASTM BBACAQ  NE ISSN 0006-3002
REMARK   1
REMARK   2
REMARK   2 RESOLUTION. 2.00 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : CNS 1.1
REMARK   3   AUTHORS     : BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE-
REMARK   3               : KUNSTLEVE,JIANG,KUSZEWSKI,NILGES, PANNU,
REMARK   3               : READ,RICE,SIMONSON,WARREN
REMARK   3
REMARK   3  REFINEMENT TARGET : ENGH & HUBER
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.00
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 24.94
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000
REMARK   3   DATA CUTOFF HIGH         (ABS(F)) : 2543611.470
REMARK   3   DATA CUTOFF LOW          (ABS(F)) : 0.0000
REMARK   3   COMPLETENESS (WORKING+TEST)   (%) : 97.7
REMARK   3   NUMBER OF REFLECTIONS             : 21661
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE            (WORKING SET) : 0.208
REMARK   3   FREE R VALUE                     : 0.250
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000
REMARK   3   FREE R VALUE TEST SET COUNT      : 1093
REMARK   3   ESTIMATED ERROR OF FREE R VALUE  : 0.008
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 10
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.00
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.07
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 91.50
REMARK   3   REFLECTIONS IN BIN    (WORKING SET) : 1888
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2960
REMARK   3   BIN FREE R VALUE                    : 0.3470
REMARK   3   BIN FREE R VALUE TEST SET SIZE  (%) : 4.70
REMARK   3   BIN FREE R VALUE TEST SET COUNT     : 94
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE : 0.036
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 2702
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 0
REMARK   3   SOLVENT ATOMS            : 280
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 17.30
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 20.60
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : 2.26000
REMARK   3    B22 (A**2) : 2.26000
REMARK   3    B33 (A**2) : -4.52000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED COORDINATE ERROR.
REMARK   3   ESD FROM LUZZATI PLOT        (A) : 0.23
REMARK   3   ESD FROM SIGMAA              (A) : 0.20
REMARK   3   LOW RESOLUTION CUTOFF        (A) : 5.00
REMARK   3
REMARK   3  CROSS-VALIDATED ESTIMATED COORDINATE ERROR.
REMARK   3   ESD FROM C-V LUZZATI PLOT    (A) : 0.27
REMARK   3   ESD FROM C-V SIGMAA          (A) : 0.23
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES.
REMARK   3   BOND LENGTHS                 (A) : 0.005
REMARK   3   BOND ANGLES            (DEGREES) : 1.20
REMARK   3   DIHEDRAL ANGLES        (DEGREES) : 24.40
REMARK   3   IMPROPER ANGLES        (DEGREES) : 0.67
REMARK   3
REMARK   3  ISOTROPIC THERMAL MODEL : RESTRAINED
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.    RMS    SIGMA
REMARK   3   MAIN-CHAIN BOND              (A**2) : 1.180 ; 1.500
REMARK   3   MAIN-CHAIN ANGLE             (A**2) : 1.720 ; 2.000
REMARK   3   SIDE-CHAIN BOND              (A**2) : 1.980 ; 2.000
REMARK   3   SIDE-CHAIN ANGLE             (A**2) : 2.770 ; 2.500
REMARK   3
REMARK   3  BULK SOLVENT MODELING.
REMARK   3   METHOD USED : FLAT MODEL
REMARK   3   KSOL        : 0.35
REMARK   3   BSOL        : 43.11
REMARK   3
REMARK   3  NCS MODEL : NULL
REMARK   3
REMARK   3  NCS RESTRAINTS.                         RMS   SIGMA/WEIGHT
REMARK   3   GROUP  1  POSITIONAL            (A) : NULL  ; NULL
REMARK   3   GROUP  1  B-FACTOR           (A**2) : NULL  ; NULL
REMARK   3
REMARK   3  PARAMETER FILE  1  : PROTEIN_REP.PARAM
REMARK   3  PARAMETER FILE  2  : WATER_REP.PARAM
REMARK   3  PARAMETER FILE  3  : NULL
REMARK   3  TOPOLOGY FILE  1   : PROTEIN.TOP
REMARK   3  TOPOLOGY FILE  2   : WATER.TOP
REMARK   3  TOPOLOGY FILE  3   : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 2QXT COMPLIES WITH FORMAT V. 3.1, 1-AUG-2007
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ.
REMARK 100 THE RCSB ID CODE IS RCSB044179.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 10-SEP-2003
REMARK 200  TEMPERATURE           (KELVIN) : 100.0
REMARK 200  PH                             : 4.50
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : N
REMARK 200  RADIATION SOURCE               : ROTATING ANODE
REMARK 200  BEAMLINE                       : NULL
REMARK 200  X-RAY GENERATOR MODEL          : RIGAKU RUH3R
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.5418
REMARK 200  MONOCHROMATOR                  : OSMIC MIRROR SYSTEM
REMARK 200  OPTICS                         : MIRRORS
REMARK 200
REMARK 200  DETECTOR TYPE                  : IMAGE PLATE
REMARK 200  DETECTOR MANUFACTURER          : MAR SCANNER 345 MM PLATE
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : DENZO
REMARK 200  DATA SCALING SOFTWARE          : SCALEPACK
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 21687
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.000
REMARK 200  RESOLUTION RANGE LOW       (A) : 25.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 0.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 97.7
REMARK 200  DATA REDUNDANCY                : 4.200
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : 0.10600
REMARK 200   FOR THE DATA SET  : 11.1000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.00
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.07
REMARK 200  COMPLETENESS FOR SHELL     (%) : 95.4
REMARK 200  DATA REDUNDANCY IN SHELL       : 4.00
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : 0.45700
REMARK 200   FOR SHELL         : 2.300
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: MOLREP
REMARK 200 STARTING MODEL: PDB ENTRY 1I6W
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 39.98
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.05
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 26% PEG 4000, 50MM SODIUM CITRATE
REMARK 280  PH 4.5, 50MM AMMONIUM SULFATE, VAPOR DIFFUSION, TEMPERATURE
REMARK 280  298K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 43 21 2
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,-Y,1/2+Z
REMARK 290       3555   1/2-Y,1/2+X,3/4+Z
REMARK 290       4555   1/2+Y,1/2-X,1/4+Z
REMARK 290       5555   1/2-X,1/2+Y,3/4-Z
REMARK 290       6555   1/2+X,1/2-Y,1/4-Z
REMARK 290       7555   Y,X,-Z
REMARK 290       8555   -Y,-X,1/2-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       56.00800
REMARK 290   SMTRY1   3  0.000000 -1.000000  0.000000       37.46800
REMARK 290   SMTRY2   3  1.000000  0.000000  0.000000       37.46800
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000       84.01200
REMARK 290   SMTRY1   4  0.000000  1.000000  0.000000       37.46800
REMARK 290   SMTRY2   4 -1.000000  0.000000  0.000000       37.46800
REMARK 290   SMTRY3   4  0.000000  0.000000  1.000000       28.00400
REMARK 290   SMTRY1   5 -1.000000  0.000000  0.000000       37.46800
REMARK 290   SMTRY2   5  0.000000  1.000000  0.000000       37.46800
REMARK 290   SMTRY3   5  0.000000  0.000000 -1.000000       84.01200
REMARK 290   SMTRY1   6  1.000000  0.000000  0.000000       37.46800
REMARK 290   SMTRY2   6  0.000000 -1.000000  0.000000       37.46800
REMARK 290   SMTRY3   6  0.000000  0.000000 -1.000000       28.00400
REMARK 290   SMTRY1   7  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY2   7  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   7  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   8  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY2   8 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   8  0.000000  0.000000 -1.000000       56.00800
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMER
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMER
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 3
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMER
REMARK 350 SOFTWARE USED: PISA
REMARK 350 AVERAGE BURIED SURFACE AREA: 990 ANGSTROM**2
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   2  0.000000  1.000000  0.000000      -74.93600
REMARK 350   BIOMT2   2  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT3   2  0.000000  0.000000 -1.000000      112.01600
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS
REMARK 500
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.
REMARK 500
REMARK 500 DISTANCE CUTOFF:
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE
REMARK 500   NE2  GLN B   178     NE2  GLN B   178     8775     1.52
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    SER A  77     -121.39     49.17
REMARK 500    LEU A  90     -148.36   -103.32
REMARK 500    ALA A  97      -67.43   -107.65
REMARK 500    ALA A 105       47.53    -90.26
REMARK 500    GLN A 121      116.48   -163.82
REMARK 500    SER B  77     -123.67     50.45
REMARK 500    LEU B  90     -147.94   -106.24
REMARK 500    ALA B 105       49.81    -92.53
REMARK 500    GLN B 121      116.85   -163.38
REMARK 500    ASN B 179       96.33   -163.71
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M=MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH B 276        DISTANCE =  6.72 ANGSTROMS
REMARK 525    HOH B 279        DISTANCE =  6.75 ANGSTROMS
REMARK 525    HOH B 316        DISTANCE =  5.91 ANGSTROMS
REMARK 525    HOH B 317        DISTANCE =  6.09 ANGSTROMS
REMARK 525    HOH B 319        DISTANCE =  5.62 ANGSTROMS
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 2QXU   RELATED DB: PDB
REMARK 900 THE SAME PROTEIN CRYSTALLIZED AT PH 5.0
DBREF  2QXT A    3   181  UNP    P37957   LIP_BACSU       34    212
DBREF  2QXT B    3   181  UNP    P37957   LIP_BACSU       34    212
SEQRES   1 A  179  HIS ASN PRO VAL VAL MET VAL HIS GLY ILE GLY GLY ALA
SEQRES   2 A  179  SER PHE ASN PHE ALA GLY ILE LYS SER TYR LEU VAL SER
SEQRES   3 A  179  GLN GLY TRP SER ARG ASP LYS LEU TYR ALA VAL ASP PHE
SEQRES   4 A  179  TRP ASP LYS THR GLY THR ASN TYR ASN ASN GLY PRO VAL
SEQRES   5 A  179  LEU SER ARG PHE VAL GLN LYS VAL LEU ASP GLU THR GLY
SEQRES   6 A  179  ALA LYS LYS VAL ASP ILE VAL ALA HIS SER MET GLY GLY
SEQRES   7 A  179  ALA ASN THR LEU TYR TYR ILE LYS ASN LEU ASP GLY GLY
SEQRES   8 A  179  ASN LYS VAL ALA ASN VAL VAL THR LEU GLY GLY ALA ASN
SEQRES   9 A  179  ARG LEU THR THR GLY LYS ALA LEU PRO GLY THR ASP PRO
SEQRES  10 A  179  ASN GLN LYS ILE LEU TYR THR SER ILE TYR SER SER ALA
SEQRES  11 A  179  ASP MET ILE VAL MET ASN TYR LEU SER ARG LEU ASP GLY
SEQRES  12 A  179  ALA ARG ASN VAL GLN ILE HIS GLY VAL GLY HIS ILE GLY
SEQRES  13 A  179  LEU LEU TYR SER SER GLN VAL ASN SER LEU ILE LYS GLU
SEQRES  14 A  179  GLY LEU ASN GLY GLY GLY GLN ASN THR ASN
SEQRES   1 B  179  HIS ASN PRO VAL VAL MET VAL HIS GLY ILE GLY GLY ALA
SEQRES   2 B  179  SER PHE ASN PHE ALA GLY ILE LYS SER TYR LEU VAL SER
SEQRES   3 B  179  GLN GLY TRP SER ARG ASP LYS LEU TYR ALA VAL ASP PHE
SEQRES   4 B  179  TRP ASP LYS THR GLY THR ASN TYR ASN ASN GLY PRO VAL
SEQRES   5 B  179  LEU SER ARG PHE VAL GLN LYS VAL LEU ASP GLU THR GLY
SEQRES   6 B  179  ALA LYS LYS VAL ASP ILE VAL ALA HIS SER MET GLY GLY
SEQRES   7 B  179  ALA ASN THR LEU TYR TYR ILE LYS ASN LEU ASP GLY GLY
SEQRES   8 B  179  ASN LYS VAL ALA ASN VAL VAL THR LEU GLY GLY ALA ASN
SEQRES   9 B  179  ARG LEU THR THR GLY LYS ALA LEU PRO GLY THR ASP PRO
SEQRES  10 B  179  ASN GLN LYS ILE LEU TYR THR SER ILE TYR SER SER ALA
SEQRES  11 B  179  ASP MET ILE VAL MET ASN TYR LEU SER ARG LEU ASP GLY
SEQRES  12 B  179  ALA ARG ASN VAL GLN ILE HIS GLY VAL GLY HIS ILE GLY
SEQRES  13 B  179  LEU LEU TYR SER SER GLN VAL ASN SER LEU ILE LYS GLU
SEQRES  14 B  179  GLY LEU ASN GLY GLY GLY GLN ASN THR ASN
FORMUL   3  HOH   *280(H2 O)
HELIX    1   1 ALA A   15  ASN A   18  5                                   4
HELIX    2   2 PHE A   19  GLN A   29  1                                  11
HELIX    3   3 SER A   32  ASP A   34  5                                   3
HELIX    4   4 THR A   47  GLY A   67  1                                  21
HELIX    5   5 MET A   78  ASN A   89  1                                  12
HELIX    6   6 ALA A  105  THR A  109  5                                   5
HELIX    7   7 MET A  137  ARG A  142  1                                   6
HELIX    8   8 ILE A  157  TYR A  161  5                                   5
HELIX    9   9 SER A  162  ASN A  174  1                                  13
HELIX   10  10 ALA B   15  ASN B   18  5                                   4
HELIX   11  11 PHE B   19  SER B   28  1                                  10
HELIX   12  12 SER B   32  ASP B   34  5                                   3
HELIX   13  13 THR B   47  GLY B   67  1                                  21
HELIX   14  14 MET B   78  ASN B   89  1                                  12
HELIX   15  15 ASP B   91  ASN B   94  5                                   4
HELIX   16  16 ALA B  105  THR B  109  5                                   5
HELIX   17  17 MET B  137  ARG B  142  1                                   6
HELIX   18  18 ILE B  157  TYR B  161  5                                   5
HELIX   19  19 SER B  162  ASN B  174  1                                  13
SHEET    1   A 6 LEU A  36  ALA A  38  0
SHEET    2   A 6 VAL A   6  VAL A   9  1  N  VAL A   6   O  TYR A  37
SHEET    3   A 6 VAL A  71  HIS A  76  1  O  ASP A  72   N  VAL A   7
SHEET    4   A 6 VAL A  96  LEU A 102  1  O  LEU A 102   N  ALA A  75
SHEET    5   A 6 LEU A 124  SER A 130  1  O  ILE A 128   N  THR A 101
SHEET    6   A 6 ARG A 147  ILE A 151  1  O  ILE A 151   N  TYR A 129
SHEET    1   B 6 LEU B  36  ALA B  38  0
SHEET    2   B 6 VAL B   6  VAL B   9  1  N  VAL B   6   O  TYR B  37
SHEET    3   B 6 VAL B  71  HIS B  76  1  O  ASP B  72   N  VAL B   7
SHEET    4   B 6 VAL B  96  LEU B 102  1  O  ASN B  98   N  ILE B  73
SHEET    5   B 6 LEU B 124  SER B 130  1  O  LEU B 124   N  VAL B  99
SHEET    6   B 6 ARG B 147  ILE B 151  1  O  VAL B 149   N  SER B 127
CRYST1   74.936   74.936  112.016  90.00  90.00  90.00 P 43 21 2    16
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.013345  0.000000  0.000000        0.00000
SCALE2      0.000000  0.013345  0.000000        0.00000
SCALE3      0.000000  0.000000  0.008927        0.00000
TER    1352      ASN A 181
TER    2704      ASN B 181
MASTER      317    0    0   19   12    0    0    6 2982    2    0   28
END