longtext: 2ROQ-pdb

content
HEADER    TRANSFERASE                             05-APR-08   2ROQ
TITLE     SOLUTION STRUCTURE OF THE THIOLATION-THIOESTERASE DI-DOMAIN
TITLE    2 OF ENTEROBACTIN SYNTHETASE COMPONENT F
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: ENTEROBACTIN SYNTHETASE COMPONENT F;
COMPND   3 CHAIN: A;
COMPND   4 FRAGMENT: TTE, UNP RESIDUES 960-1293;
COMPND   5 SYNONYM: ENTEROCHELIN SYNTHASE F, SERINE-ACTIVATING ENZYME,
COMPND   6 SERYL-AMP LIGASE;
COMPND   7 EC: 2.7.7.-;
COMPND   8 ENGINEERED: YES;
COMPND   9 MUTATION: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI;
SOURCE   3 GENE: ENT;
SOURCE   4 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   5 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);
SOURCE   6 EXPRESSION_SYSTEM_VECTOR_TYPE: VECTOR;
SOURCE   7 EXPRESSION_SYSTEM_VECTOR: PET30A+
KEYWDS    ENTF, T-TE, PCP, THIOESTERASE, PEPTIDYL CARRIER PROTEIN,
KEYWDS   2 THIOLATION DOMAIN, ENTEROBACTIN, NON-RIBOSOMAL PEPTIDE
KEYWDS   3 SYNTHETASE, NRPS, ALPHA/BETA-HYDROLASE, DIDOMAIN,
KEYWDS   4 ENTEROBACTIN BIOSYNTHESIS, ION TRANSPORT, IRON, IRON
KEYWDS   5 TRANSPORT, LIGASE, MULTIFUNCTIONAL ENZYME,
KEYWDS   6 PHOSPHOPANTETHEINE, TRANSFERASE, TRANSPORT
EXPDTA    NMR, 20 STRUCTURES
AUTHOR    D.P.FRUEH,H.ARTHANARI,A.KOGLIN,D.A.VOSBURG,A.E.BENNETT,
AUTHOR   2 C.T.WALSH,G.WAGNER
REVDAT   1   12-AUG-08 2ROQ    0
JRNL        AUTH   D.P.FRUEH,H.ARTHANARI,A.KOGLIN,D.A.VOSBURG,
JRNL        AUTH 2 A.E.BENNETT,C.T.WALSH,G.WAGNER
JRNL        TITL   DYNAMIC THIOLATION-THIOESTERASE DI-DOMAIN
JRNL        TITL 2 STRUCTURE OF A NON-RIBOSOMAL PEPTIDE SYNTHETASE
JRNL        REF    NATURE                                     2008
JRNL        REFN   ASTM NATUAS  UK ESSN 1476-4687
REMARK   1
REMARK   2
REMARK   2 RESOLUTION. NOT APPLICABLE.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : CNS
REMARK   3   AUTHORS     : BRUNGER, ADAMS, CLORE, GROS, NILGES AND READ
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 2ROQ COMPLIES WITH FORMAT V. 3.1, 01-AUG-2007
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ.
REMARK 100 THE RCSB ID CODE IS RCSB150103.
REMARK 210
REMARK 210 EXPERIMENTAL DETAILS
REMARK 210  EXPERIMENT TYPE                : NMR
REMARK 210  TEMPERATURE           (KELVIN) : 298
REMARK 210  PH                             : 6.72
REMARK 210  IONIC STRENGTH                 : 150 MM NACL, 20 MM NAPI
REMARK 210  PRESSURE                       : AMBIENT
REMARK 210  SAMPLE CONTENTS                : 0.3 MM [U-100% 15N] TTE, 20
REMARK 210                                   MM SODIUM PHOSPHATE, 150 MM
REMARK 210                                   SODIUM CHLORIDE, 1 MM EDTA, 1
REMARK 210                                   MM DTT, 95% H2O/5% D2O; 0.3 MM
REMARK 210                                   [U-13C; U-15N; U-2H] TTE, 20
REMARK 210                                   MM SODIUM PHOSPHATE, 150 MM
REMARK 210                                   SODIUM CHLORIDE, 1 MM EDTA, 1
REMARK 210                                   MM DTT, 95% H2O/5% D2O; 0.3 MM
REMARK 210                                   1H-ME-ILV-U-2H-U13C-U15N TTE,
REMARK 210                                   20 MM SODIUM PHOSPHATE, 150 MM
REMARK 210                                   SODIUM CHLORIDE, 1 MM EDTA, 1
REMARK 210                                   MM DTT, 95% H2O/5% D2O; 0.3 MM
REMARK 210                                   1H-13C-ME-ILV-U-2H-U12C-U15N
REMARK 210                                   TTE, 20 MM SODIUM PHOSPHATE,
REMARK 210                                   150 MM SODIUM CHLORIDE, 1 MM
REMARK 210                                   EDTA, 1 MM DTT, 95% H2O/5%
REMARK 210                                   D2O; 0.3 MM [U-98% 13C; U-98%
REMARK 210                                   15N] TTE, 20 MM SODIUM
REMARK 210                                   PHOSPHATE, 150 MM SODIUM
REMARK 210                                   CHLORIDE, 1 MM EDTA, 1 MM DTT,
REMARK 210                                   95% H2O/5% D2O; 0.1 MM 15N-
REMARK 210                                   SELECTIVE-K OR ILVYFG TTE, 20
REMARK 210                                   MM SODIUM PHOSPHATE, 150 MM
REMARK 210                                   SODIUM CHLORIDE, 1 MM EDTA, 1
REMARK 210                                   MM DTT, 95% H2O/5% D2O; 0.3 MM
REMARK 210                                   13C'-PRO-U-15N TTE, 20 MM
REMARK 210                                   SODIUM PHOSPHATE, 150 MM
REMARK 210                                   SODIUM CHLORIDE, 1 MM EDTA, 1
REMARK 210                                   MM DTT, 95% H2O/5% D2O; 0.3 MM
REMARK 210                                   70%2H-U15-U13C TTE, 20 MM
REMARK 210                                   SODIUM PHOSPHATE, 150 MM
REMARK 210                                   SODIUM CHLORIDE, 1 MM EDTA, 1
REMARK 210                                   MM DTT, 95% H2O/5% D2O; 0.3 MM
REMARK 210                                   [U-13C; U-15N] TTE, 20 MM
REMARK 210                                   SODIUM PHOSPHATE, 150 MM
REMARK 210                                   SODIUM CHLORIDE, 1 MM EDTA, 1
REMARK 210                                   MM DTT, 100% D2O
REMARK 210
REMARK 210  NMR EXPERIMENTS CONDUCTED      : 2D 1H-15N HSQC, 3D HNCO, 3D
REMARK 210                                   HNCA, 3D HNCACB, 3D HN(CO)CA,
REMARK 210                                   3D HN(CA)CO, 3D HNCO-NUS, 3D
REMARK 210                                   HNCA-NUS, 3D 13CDET-MQ-HACACO,
REMARK 210                                   3D C(CO)NH, 3D H(CCO)NH, 3D
REMARK 210                                   HCCH-COSY, 3D 1H-15N NOESY, 3D
REMARK 210                                   HCCH-TOCSY, 3D-TS-NOESY-HSQC,
REMARK 210                                   4D-TS-HSQC-NOESY-HSQC, 3D-HSQC
REMARK 210                                   -NOESY, 3D-HN(CA)NH-NUS, 3D-
REMARK 210                                   HNCOCACB
REMARK 210  SPECTROMETER FIELD STRENGTH    : 900 MHZ, 750 MHZ, 600 MHZ,
REMARK 210                                   500 MHZ
REMARK 210  SPECTROMETER MODEL             : AVANCE II
REMARK 210  SPECTROMETER MANUFACTURER      : BRUKER
REMARK 210
REMARK 210  STRUCTURE DETERMINATION.
REMARK 210   SOFTWARE USED                 : CYANA 2.1, CARA 1.8.2, TALOS,
REMARK 210                                   NMRPIPE 05, MOLMOL 2K
REMARK 210   METHOD USED                   : NULL
REMARK 210
REMARK 210 CONFORMERS, NUMBER CALCULATED   : 200
REMARK 210 CONFORMERS, NUMBER SUBMITTED    : 20
REMARK 210 CONFORMERS, SELECTION CRITERIA  : STRUCTURES WITH THE LOWEST
REMARK 210                                   ENERGY
REMARK 210
REMARK 210 BEST REPRESENTATIVE CONFORMER IN THIS ENSEMBLE : 1
REMARK 210
REMARK 210 REMARK: NUS: NON-UNIFORMLY SAMPLED. TS: TIME-SHARED. ALL
REMARK 210  EXPERIMENTS ARE TROSY EXCEPT FOR THE TS-HSQC-NOESY.HN(CA)NH IS
REMARK 210  DOUBLE TROSY.
REMARK 215
REMARK 215 NMR STUDY
REMARK 215 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM SOLUTION
REMARK 215 NMR DATA.  PROTEIN DATA BANK CONVENTIONS REQUIRE THAT
REMARK 215 CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES ON
REMARK 215 THESE RECORDS ARE MEANINGLESS.
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500  1 LEU A   2      154.70     64.25
REMARK 500  1 ALA A   7      -77.25     68.99
REMARK 500  1 GLN A   8       86.88     60.29
REMARK 500  1 ALA A  13       66.87     64.61
REMARK 500  1 PRO A  14     -170.45    -69.73
REMARK 500  1 LYS A  15     -169.35    -70.23
REMARK 500  1 LEU A  29      -67.55    -97.70
REMARK 500  1 ASP A  33       31.91    175.38
REMARK 500  1 GLN A  35       32.63   -163.94
REMARK 500  1 THR A  67      -58.12    173.22
REMARK 500  1 VAL A  71      -75.32   -149.45
REMARK 500  1 VAL A  73      -38.59   -157.67
REMARK 500  1 SER A  75      -74.83    179.43
REMARK 500  1 THR A  76     -172.93   -173.97
REMARK 500  1 ALA A  86      -76.92    -92.80
REMARK 500  1 GLU A  87      153.08    179.85
REMARK 500  1 GLU A  88      -75.30    -53.22
REMARK 500  1 ARG A  93      100.03    -50.85
REMARK 500  1 MET A  94      174.96    -57.92
REMARK 500  1 GLU A  97     -169.94    -70.25
REMARK 500  1 ASN A 106      -73.74   -119.72
REMARK 500  1 HIS A 114       56.81     70.12
REMARK 500  1 GLN A 133       40.81    179.79
REMARK 500  1 TRP A 134     -173.28    -58.85
REMARK 500  1 ASN A 145       43.87   -179.63
REMARK 500  1 SER A 180      -81.08     66.73
REMARK 500  1 PHE A 202      123.24   -173.46
REMARK 500  1 ASP A 207      -77.88    175.84
REMARK 500  1 THR A 208      119.03    179.22
REMARK 500  1 TRP A 209       75.17   -175.29
REMARK 500  1 PRO A 211       93.71    -69.71
REMARK 500  1 GLU A 212      -69.67   -170.90
REMARK 500  1 GLN A 214     -175.39    -58.05
REMARK 500  1 LYS A 219       86.31   -153.10
REMARK 500  1 LEU A 224       97.27    -64.36
REMARK 500  1 SER A 248      -76.35    -49.98
REMARK 500  1 ASP A 275       52.08    -91.76
REMARK 500  1 ALA A 283       77.14   -110.81
REMARK 500  1 SER A 292       72.18   -157.46
REMARK 500  1 PRO A 293     -179.64    -69.76
REMARK 500  1 GLU A 294       77.11   -161.14
REMARK 500  1 SER A 298       73.64     61.75
REMARK 500  1 TRP A 300      -73.78    -51.99
REMARK 500  1 ASP A 310       92.68    -63.99
REMARK 500  1 ILE A 325       50.87    -98.46
REMARK 500  1 HIS A 339     -178.32     60.66
REMARK 500  2 ALA A   9      -61.46   -179.22
REMARK 500  2 ALA A  13      154.53     66.33
REMARK 500  2 LYS A  15      -32.31    178.19
REMARK 500  2 CYS A  32      117.90     66.57
REMARK 500  2 ASP A  33      -32.77    176.77
REMARK 500  2 GLN A  35       20.46   -152.25
REMARK 500  2 HIS A  47      -61.31   -175.04
REMARK 500  2 LEU A  50      -52.23   -122.34
REMARK 500  2 PRO A  68       79.10    -69.81
REMARK 500  2 MET A  72       39.06    -98.11
REMARK 500  2 VAL A  73      -32.06   -168.35
REMARK 500  2 SER A  75      -68.45    173.91
REMARK 500  2 ALA A  86      -69.78   -107.86
REMARK 500  2 GLU A  87      148.99   -171.79
REMARK 500  2 GLU A  88       38.43    -94.87
REMARK 500  2 ARG A  92      -69.93    -98.56
REMARK 500  2 ARG A  93      -65.30    -99.37
REMARK 500  2 ASN A 106      -76.28   -128.67
REMARK 500  2 HIS A 114       60.82     75.31
REMARK 500  2 SER A 117      124.96   -174.43
REMARK 500  2 PHE A 119       97.54     58.96
REMARK 500  2 ALA A 120       46.66   -103.79
REMARK 500  2 ASP A 131       82.89    166.31
REMARK 500  2 PRO A 142     -176.55    -69.72
REMARK 500  2 ASN A 145      -32.28   -130.88
REMARK 500  2 SER A 180      -88.01     62.86
REMARK 500  2 PHE A 202      110.02   -173.06
REMARK 500  2 THR A 208      -39.86   -144.80
REMARK 500  2 TRP A 209      160.26     62.02
REMARK 500  2 THR A 213      -73.97    -56.24
REMARK 500  2 LYS A 219       93.54   -162.98
REMARK 500  2 ASN A 222       36.64   -171.27
REMARK 500  2 PHE A 239      -60.63    -97.86
REMARK 500  2 GLN A 244      148.20   -176.66
REMARK 500  2 THR A 247      102.73    -50.61
REMARK 500  2 THR A 249       20.44   -159.26
REMARK 500  2 THR A 254      -70.31    -66.24
REMARK 500  2 ALA A 269     -174.66    -59.98
REMARK 500  2 GLN A 288       60.51   -105.61
REMARK 500  2 ARG A 295      -74.41    -99.27
REMARK 500  2 TRP A 297      133.28   -176.29
REMARK 500  2 PRO A 299     -170.68    -69.72
REMARK 500  2 TRP A 300      -75.87    -95.12
REMARK 500  2 ILE A 301      145.05     66.01
REMARK 500  2 HIS A 338      -62.80   -165.88
REMARK 500  3 PRO A   3     -171.84    -69.74
REMARK 500  3 ALA A   9       66.14   -178.63
REMARK 500  3 PRO A  14      -89.02    -69.73
REMARK 500  3 LYS A  15      -68.60    178.20
REMARK 500  3 LEU A  29      -66.61    -96.46
REMARK 500  3 CYS A  32      -58.10     74.46
REMARK 500  3 GLN A  35       30.70   -160.03
REMARK 500  3 PHE A  41      -70.21    -49.02
REMARK 500  3 HIS A  47       58.26   -178.69
REMARK 500  3 ALA A  48      -71.05     71.02
REMARK 500  3 VAL A  71      -51.29   -122.86
REMARK 500  3 MET A  72       33.65    -95.63
REMARK 500  3 VAL A  73      -32.24   -168.55
REMARK 500  3 SER A  75      -76.18   -175.74
REMARK 500  3 ALA A  86       80.73   -168.84
REMARK 500  3 GLU A  88     -169.82    -78.03
REMARK 500  3 ASP A  89      -73.47    -51.21
REMARK 500  3 THR A  91      113.23   -174.36
REMARK 500  3 ASN A 106      -75.10   -124.94
REMARK 500  3 PRO A 115     -166.35    -69.75
REMARK 500  3 SER A 117      -70.29   -102.36
REMARK 500  3 GLN A 133       87.47    179.55
REMARK 500  3 ASN A 145       67.01   -177.24
REMARK 500  3 SER A 180      -85.89     61.65
REMARK 500  3 PHE A 202      114.57   -172.08
REMARK 500  3 ASP A 207       76.67     51.30
REMARK 500  3 THR A 208      -52.62   -161.33
REMARK 500  3 TRP A 209       76.54     63.45
REMARK 500  3 PRO A 211     -172.61    -69.71
REMARK 500  3 ASN A 215     -176.16    -58.88
REMARK 500  3 ASN A 222       -7.70     86.14
REMARK 500  3 PHE A 239      -63.50    -97.72
REMARK 500  3 GLN A 244      -74.07    -92.25
REMARK 500  3 ALA A 269      177.10    -55.89
REMARK 500  3 GLN A 288      -51.05   -124.28
REMARK 500  3 GLU A 294      -72.52   -147.40
REMARK 500  3 ALA A 296       84.13     63.84
REMARK 500  3 TRP A 297      115.01   -173.36
REMARK 500  3 PRO A 299     -171.11    -69.75
REMARK 500  3 TRP A 300       45.37    -95.15
REMARK 500  3 HIS A 339      110.42   -162.78
REMARK 500  3 HIS A 341      147.08   -171.75
REMARK 500  4 LYS A   6      -74.48    -66.93
REMARK 500  4 ALA A  13       74.66   -179.47
REMARK 500  4 CYS A  32     -169.93     69.50
REMARK 500  4 GLN A  35       46.56   -147.39
REMARK 500  4 HIS A  47     -168.68    177.90
REMARK 500  4 THR A  67      -58.42    177.51
REMARK 500  4 PRO A  68       94.10    -69.72
REMARK 500  4 VAL A  73      -31.76   -174.62
REMARK 500  4 SER A  75      -72.41    173.75
REMARK 500  4 THR A  76     -171.84   -173.27
REMARK 500  4 ALA A  86       78.84   -172.97
REMARK 500  4 GLU A  87       99.46    -64.16
REMARK 500  4 ARG A  93      -70.96    -51.81
REMARK 500  4 ARG A 103      110.55   -165.39
REMARK 500  4 ASN A 106      -75.42   -121.36
REMARK 500  4 GLN A 133       33.96    179.97
REMARK 500  4 TRP A 134     -165.54   -117.55
REMARK 500  4 SER A 141      107.13   -161.40
REMARK 500  4 PRO A 142       89.76    -69.73
REMARK 500  4 ASN A 145       61.08    177.33
REMARK 500  4 SER A 180      -86.33     63.16
REMARK 500  4 GLU A 212     -168.72   -177.72
REMARK 500  4 GLN A 214     -176.35    179.79
REMARK 500  4 ASN A 215      -72.75   -101.72
REMARK 500  4 PHE A 239      -65.50    -98.26
REMARK 500  4 GLN A 244      -73.41   -116.37
REMARK 500  4 THR A 249      -76.56   -155.79
REMARK 500  4 ALA A 269     -174.91    -58.90
REMARK 500  4 ASP A 275       60.94   -107.60
REMARK 500  4 GLN A 288      -71.78   -119.48
REMARK 500  4 SER A 292       70.45     58.46
REMARK 500  4 PRO A 293       78.86    -69.75
REMARK 500  4 ARG A 295     -175.57     59.21
REMARK 500  4 ALA A 296       84.94     60.61
REMARK 500  4 TRP A 297      -51.64   -139.24
REMARK 500  4 SER A 298       70.41     58.06
REMARK 500  4 ASP A 310       94.35    -65.31
REMARK 500  4 HIS A 338      -61.98   -145.44
REMARK 500  4 HIS A 341       48.59   -144.41
REMARK 500  4 HIS A 342     -171.37     59.63
REMARK 500  5 LEU A   2       73.21   -155.56
REMARK 500  5 GLN A   8       88.61     62.96
REMARK 500  5 ALA A   9       63.38     66.26
REMARK 500  5 LYS A  15       28.97   -173.69
REMARK 500  5 ASP A  33       40.50    167.02
REMARK 500  5 ASP A  36      -84.67   -179.65
REMARK 500  5 HIS A  47       64.85   -168.70
REMARK 500  5 ALA A  48      -77.86     67.79
REMARK 500  5 GLN A  70       33.99    -95.29
REMARK 500  5 VAL A  71      -51.02   -146.84
REMARK 500  5 VAL A  73       15.82   -147.86
REMARK 500  5 SER A  75      -72.07    171.22
REMARK 500  5 ALA A  86       35.88    -94.95
REMARK 500  5 SER A  90      100.21    -59.85
REMARK 500  5 PHE A  96      106.09    -49.78
REMARK 500  5 ASN A 106      -41.16   -140.59
REMARK 500  5 PRO A 115     -164.27    -69.76
REMARK 500  5 ALA A 116      -75.95    -39.78
REMARK 500  5 ASP A 131       88.50    169.07
REMARK 500  5 ASN A 145       15.19   -145.79
REMARK 500  5 PRO A 147      -86.39    -69.74
REMARK 500  5 SER A 180      -82.69     65.51
REMARK 500  5 PHE A 202      114.62   -161.26
REMARK 500  5 ASP A 207       63.13     66.49
REMARK 500  5 GLU A 212       70.84   -174.55
REMARK 500  5 LYS A 219       86.93   -155.64
REMARK 500  5 ASN A 222       28.06   -151.90
REMARK 500  5 SER A 248      -72.11    -49.99
REMARK 500  5 THR A 249       15.96   -147.84
REMARK 500  5 ALA A 269     -174.73    -59.14
REMARK 500  5 SER A 292       73.19   -178.98
REMARK 500  5 PRO A 293       94.52    -69.74
REMARK 500  5 SER A 298       69.68   -172.69
REMARK 500  5 TRP A 300       59.38   -119.64
REMARK 500  5 ILE A 325       39.16    -93.56
REMARK 500  5 HIS A 340       60.28   -152.28
REMARK 500  5 HIS A 341       98.20   -163.11
REMARK 500  6 LEU A   2       70.34   -151.63
REMARK 500  6 LYS A   6       70.99     52.42
REMARK 500  6 ALA A   9       66.32   -179.38
REMARK 500  6 ALA A  13      155.57     64.06
REMARK 500  6 PRO A  14     -170.46    -69.78
REMARK 500  6 CYS A  32      123.52     68.83
REMARK 500  6 ASP A  33      -30.25    176.97
REMARK 500  6 ASP A  38       34.65    -92.92
REMARK 500  6 HIS A  47     -179.75    177.78
REMARK 500  6 VAL A  71      -34.52   -133.08
REMARK 500  6 GLU A  97     -179.84   -172.99
REMARK 500  6 ARG A 103      106.10   -176.11
REMARK 500  6 ASN A 106      -75.16    -62.37
REMARK 500  6 HIS A 114      154.91    -49.88
REMARK 500  6 PRO A 115     -172.14    -69.76
REMARK 500  6 ALA A 116       46.51    -90.84
REMARK 500  6 SER A 117      -75.42   -104.75
REMARK 500  6 ALA A 120       54.81   -100.56
REMARK 500  6 LEU A 130      -83.22    -59.78
REMARK 500  6 ASP A 131      142.24    176.75
REMARK 500  6 TRP A 134      109.90    -47.66
REMARK 500  6 SER A 141      106.58   -165.62
REMARK 500  6 PRO A 142     -164.92    -69.74
REMARK 500  6 PRO A 147       66.53    -69.79
REMARK 500  6 THR A 150       -9.62    -59.84
REMARK 500  6 ASN A 153      -77.30    -37.70
REMARK 500  6 PRO A 170        6.17    -69.73
REMARK 500  6 LEU A 177      118.21   -169.77
REMARK 500  6 SER A 180      -83.13     65.07
REMARK 500  6 PHE A 202      109.31   -164.12
REMARK 500  6 ASP A 207      157.87    177.30
REMARK 500  6 ALA A 221       50.86   -179.17
REMARK 500  6 PHE A 239      -60.59    -97.61
REMARK 500  6 GLN A 243       23.49   -157.62
REMARK 500  6 GLN A 244       19.45     59.25
REMARK 500  6 SER A 246      -74.86   -128.87
REMARK 500  6 THR A 249      -76.74   -157.99
REMARK 500  6 ALA A 269     -175.21    -63.69
REMARK 500  6 ALA A 283       77.13   -110.76
REMARK 500  6 GLN A 288      -62.66   -141.50
REMARK 500  6 GLU A 289       42.11   -104.00
REMARK 500  6 SER A 292       69.80   -172.43
REMARK 500  6 ARG A 295       49.09   -158.53
REMARK 500  6 ALA A 296      -70.60   -100.04
REMARK 500  6 TRP A 297       90.14   -178.65
REMARK 500  6 SER A 298       73.28     56.59
REMARK 500  6 ILE A 301      152.11     65.26
REMARK 500  6 HIS A 338      -59.93   -168.98
REMARK 500  6 HIS A 339       95.66   -163.76
REMARK 500  6 HIS A 342      -55.05   -162.40
REMARK 500  7 GLN A   8       82.30     55.00
REMARK 500  7 ALA A   9       63.49     66.36
REMARK 500  7 PRO A  14     -173.04    -69.76
REMARK 500  7 LYS A  15      -78.10   -179.01
REMARK 500  7 ASP A  36      -77.83    170.25
REMARK 500  7 HIS A  47      138.03    179.19
REMARK 500  7 ALA A  48       83.91     65.50
REMARK 500  7 LEU A  49       30.65     71.00
REMARK 500  7 LEU A  50      -54.08   -141.94
REMARK 500  7 VAL A  71      -41.95   -143.46
REMARK 500  7 VAL A  73      -39.46     75.55
REMARK 500  7 SER A  75      -77.43   -179.70
REMARK 500  7 THR A  76     -174.10   -177.00
REMARK 500  7 ALA A  86      -75.22    -67.78
REMARK 500  7 GLU A  87     -169.55   -165.12
REMARK 500  7 THR A  91       99.14   -162.90
REMARK 500  7 ARG A  92      101.94    -51.92
REMARK 500  7 ARG A  93       33.13    -86.43
REMARK 500  7 MET A  94     -174.68    -58.10
REMARK 500  7 PRO A 101       99.87    -69.80
REMARK 500  7 ARG A 103      105.79   -171.93
REMARK 500  7 ASN A 106       21.85   -156.15
REMARK 500  7 PRO A 115       60.21    -69.79
REMARK 500  7 SER A 117      -75.30    -94.49
REMARK 500  7 LEU A 130      -75.23    -96.10
REMARK 500  7 GLN A 133       67.94   -177.75
REMARK 500  7 TRP A 134     -167.44   -106.35
REMARK 500  7 ASN A 145       65.61   -176.40
REMARK 500  7 SER A 180      -74.28     69.84
REMARK 500  7 LEU A 185      -71.17    -62.65
REMARK 500  7 GLU A 212      -44.34   -163.08
REMARK 500  7 ASN A 215      -76.22   -103.80
REMARK 500  7 ASN A 222       41.14   -151.82
REMARK 500  7 GLN A 243      -35.21   -179.99
REMARK 500  7 GLN A 244       62.03     65.86
REMARK 500  7 THR A 247       46.62     36.96
REMARK 500  7 SER A 271      148.11   -170.99
REMARK 500  7 PRO A 293       83.54    -69.77
REMARK 500  7 SER A 298      160.93     63.08
REMARK 500  7 ILE A 301      -60.29   -136.46
REMARK 500  7 GLU A 303      119.13   -167.43
REMARK 500  7 ASP A 310       93.46    -63.84
REMARK 500  7 HIS A 339       96.19     58.39
REMARK 500  7 HIS A 340       60.11   -169.96
REMARK 500  8 LEU A   2      154.67     64.20
REMARK 500  8 ALA A   7      127.99   -174.70
REMARK 500  8 ALA A  13       75.66   -178.58
REMARK 500  8 PRO A  14       91.07    -69.80
REMARK 500  8 LYS A  15       33.34   -179.17
REMARK 500  8 LEU A  30      -31.09   -130.22
REMARK 500  8 CYS A  32      -62.11     73.41
REMARK 500  8 GLN A  35       30.77   -165.00
REMARK 500  8 ARG A  64     -169.46   -116.47
REMARK 500  8 PRO A  68       73.23    -69.83
REMARK 500  8 GLN A  70       45.23    -89.94
REMARK 500  8 VAL A  71      -51.47   -135.82
REMARK 500  8 SER A  75      -75.55   -176.90
REMARK 500  8 THR A  76     -171.31   -176.08
REMARK 500  8 ALA A  86       75.49   -178.41
REMARK 500  8 GLU A  88      -53.90   -121.24
REMARK 500  8 MET A  94      -74.29   -141.25
REMARK 500  8 ARG A 103      122.32   -176.88
REMARK 500  8 HIS A 114       79.67   -115.55
REMARK 500  8 ALA A 116     -174.93    -58.74
REMARK 500  8 LEU A 130      -98.21   -104.81
REMARK 500  8 GLN A 133       37.36   -161.15
REMARK 500  8 HIS A 161      -72.96    -66.17
REMARK 500  8 PRO A 170        2.02    -69.74
REMARK 500  8 SER A 180      -84.90     61.48
REMARK 500  8 ASP A 207       91.99     63.87
REMARK 500  8 THR A 208       82.11   -161.45
REMARK 500  8 GLU A 212      -75.45   -170.75
REMARK 500  8 LYS A 219       93.79   -167.01
REMARK 500  8 ALA A 221      -60.86    -96.95
REMARK 500  8 ASN A 222       45.52    -93.12
REMARK 500  8 PHE A 239      -62.62    -98.83
REMARK 500  8 THR A 249      -74.68   -108.09
REMARK 500  8 ASP A 275       76.38   -106.98
REMARK 500  8 GLU A 289       77.99     56.79
REMARK 500  8 GLU A 294       83.45     62.97
REMARK 500  8 ALA A 296      143.76   -174.02
REMARK 500  8 PRO A 299     -170.69    -69.74
REMARK 500  8 ALA A 302      -62.19    -99.59
REMARK 500  8 HIS A 338      -74.45   -179.36
REMARK 500  8 HIS A 339       34.25   -178.32
REMARK 500  9 GLN A   8     -179.74   -170.87
REMARK 500  9 ALA A   9      -61.32   -179.37
REMARK 500  9 PRO A  14       84.46    -69.80
REMARK 500  9 LYS A  15       32.52   -177.58
REMARK 500  9 CYS A  32     -167.18   -115.29
REMARK 500  9 VAL A  34       99.54    -62.10
REMARK 500  9 GLN A  35       36.21   -140.66
REMARK 500  9 ASP A  36     -169.37   -104.45
REMARK 500  9 HIS A  47     -168.10    179.04
REMARK 500  9 ALA A  48       46.16    -87.69
REMARK 500  9 LEU A  49      -49.42   -146.01
REMARK 500  9 VAL A  71      -65.07     72.55
REMARK 500  9 SER A  75      -62.68    171.69
REMARK 500  9 THR A  76     -172.40   -174.66
REMARK 500  9 GLU A  88      -71.41   -100.91
REMARK 500  9 SER A  90      -68.94    -94.92
REMARK 500  9 ARG A  92      -60.57   -104.81
REMARK 500  9 GLU A  97     -165.67   -116.01
REMARK 500  9 ARG A 103      107.25   -178.56
REMARK 500  9 ASN A 106      -77.37    -65.25
REMARK 500  9 HIS A 114       57.91     74.46
REMARK 500  9 LEU A 130      -77.37    -55.74
REMARK 500  9 ASP A 131      108.70    178.70
REMARK 500  9 TRP A 134     -169.48   -121.20
REMARK 500  9 SER A 180      -84.52     62.89
REMARK 500  9 PHE A 202      109.26   -173.78
REMARK 500  9 ASP A 207     -161.02     66.03
REMARK 500  9 THR A 208       31.19     75.40
REMARK 500  9 TRP A 209      162.04     62.07
REMARK 500  9 PRO A 211       77.27    -69.73
REMARK 500  9 GLU A 212      -67.94   -174.18
REMARK 500  9 ASN A 222       41.18   -109.08
REMARK 500  9 ALA A 241      -60.28    -99.77
REMARK 500  9 ALA A 242      108.36   -178.77
REMARK 500  9 SER A 246      -63.76   -145.23
REMARK 500  9 SER A 248       37.93    -93.68
REMARK 500  9 THR A 249      -75.15   -136.82
REMARK 500  9 ALA A 269     -179.41    -58.08
REMARK 500  9 ALA A 283       77.05   -119.33
REMARK 500  9 GLN A 288      -58.83   -141.87
REMARK 500  9 TRP A 297       98.66     63.50
REMARK 500  9 ILE A 301      159.35     64.93
REMARK 500  9 GLU A 303      118.90   -165.80
REMARK 500  9 HIS A 338      115.86   -162.72
REMARK 500 10 ALA A   9       66.36   -178.57
REMARK 500 10 CYS A  32     -164.83    162.81
REMARK 500 10 GLN A  35       30.27   -171.94
REMARK 500 10 HIS A  47       85.50   -179.43
REMARK 500 10 LEU A  49       20.71   -153.93
REMARK 500 10 LEU A  50      -55.32   -153.00
REMARK 500 10 THR A  67      -57.43    162.55
REMARK 500 10 PRO A  68      -92.17    -69.80
REMARK 500 10 GLN A  70       32.88    177.65
REMARK 500 10 VAL A  71      -73.99   -152.15
REMARK 500 10 SER A  75      -65.51    167.16
REMARK 500 10 ARG A 103      110.85   -178.91
REMARK 500 10 PRO A 115     -170.81    -69.82
REMARK 500 10 TRP A 121      102.47    -51.28
REMARK 500 10 LEU A 130      -79.89    -60.69
REMARK 500 10 ASP A 131      139.89    170.26
REMARK 500 10 GLN A 133       31.87    -94.76
REMARK 500 10 ASN A 145       70.72   -176.25
REMARK 500 10 SER A 180      -78.03     67.77
REMARK 500 10 PHE A 202      132.36   -173.06
REMARK 500 10 ASP A 207      155.26     64.71
REMARK 500 10 TRP A 209      134.78   -172.27
REMARK 500 10 THR A 213      102.65    -50.93
REMARK 500 10 ASN A 222      -33.78    179.34
REMARK 500 10 LEU A 224       97.82    -65.50
REMARK 500 10 GLN A 243      -74.62    -99.50
REMARK 500 10 GLN A 244      115.70   -168.29
REMARK 500 10 THR A 247      -69.11    -99.58
REMARK 500 10 THR A 249      -72.20   -155.92
REMARK 500 10 THR A 254      -70.77    -65.95
REMARK 500 10 ALA A 269      171.87    -54.65
REMARK 500 10 PRO A 293     -170.95    -69.72
REMARK 500 10 GLU A 294       22.20   -149.92
REMARK 500 10 SER A 298      160.36     62.99
REMARK 500 10 PRO A 299       78.64    -69.73
REMARK 500 10 TRP A 300      -64.33   -139.52
REMARK 500 10 HIS A 341      167.21     63.38
REMARK 500 11 ALA A   7      -75.60   -177.39
REMARK 500 11 ALA A  13       66.90   -178.63
REMARK 500 11 PRO A  14     -176.47    -69.70
REMARK 500 11 CYS A  32     -169.82     73.02
REMARK 500 11 GLN A  35       45.75   -152.48
REMARK 500 11 ALA A  39      175.24    -56.98
REMARK 500 11 HIS A  47     -167.00   -179.03
REMARK 500 11 THR A  67      -60.28    178.81
REMARK 500 11 PRO A  68      -91.05    -69.76
REMARK 500 11 VAL A  71      -42.34   -150.94
REMARK 500 11 VAL A  73       13.61   -152.95
REMARK 500 11 SER A  75      -72.42    165.35
REMARK 500 11 THR A  76     -161.76    179.59
REMARK 500 11 ILE A  83      -62.19    -97.46
REMARK 500 11 SER A  90      -66.70    -97.32
REMARK 500 11 ARG A 103      105.91   -161.54
REMARK 500 11 ASN A 106      -74.76    -68.49
REMARK 500 11 PRO A 115     -170.42    -69.78
REMARK 500 11 ASP A 131      101.71    170.32
REMARK 500 11 GLN A 133      -66.90    -90.67
REMARK 500 11 TRP A 134      155.13    -47.96
REMARK 500 11 ASN A 145       36.60   -171.16
REMARK 500 11 SER A 180      -81.02     65.89
REMARK 500 11 PHE A 202      110.47   -168.41
REMARK 500 11 ASP A 207      -77.60    179.74
REMARK 500 11 THR A 208      152.38    177.11
REMARK 500 11 TRP A 209       71.73   -176.36
REMARK 500 11 GLU A 212     -162.69    -65.81
REMARK 500 11 THR A 213     -170.66    -58.55
REMARK 500 11 GLN A 214      -71.87    -46.30
REMARK 500 11 ALA A 221       81.95    178.73
REMARK 500 11 PHE A 239      -61.81    -98.20
REMARK 500 11 GLN A 243      -63.44   -120.95
REMARK 500 11 GLN A 244      119.35   -175.70
REMARK 500 11 SER A 246       89.24   -153.12
REMARK 500 11 THR A 247       59.66     70.99
REMARK 500 11 THR A 249      -64.18    -98.47
REMARK 500 11 GLN A 288       37.39   -159.86
REMARK 500 11 SER A 292       68.27   -174.55
REMARK 500 11 ARG A 295       62.39     63.21
REMARK 500 11 ILE A 301      144.11     66.24
REMARK 500 11 ASP A 310       92.70    -68.46
REMARK 500 11 HIS A 338       94.12     56.98
REMARK 500 11 HIS A 339     -175.84     57.79
REMARK 500 11 HIS A 342      -40.53   -130.60
REMARK 500 12 PRO A   3       85.83    -69.72
REMARK 500 12 LEU A   5      101.90    -54.31
REMARK 500 12 LYS A   6      104.56   -163.29
REMARK 500 12 ALA A   7     -168.96   -115.95
REMARK 500 12 CYS A  32     -168.91   -129.96
REMARK 500 12 ASP A  33       69.54   -101.01
REMARK 500 12 GLN A  35       42.60   -144.47
REMARK 500 12 HIS A  47      -72.32   -175.00
REMARK 500 12 VAL A  71      -61.08   -133.78
REMARK 500 12 SER A  75      -65.74    174.10
REMARK 500 12 THR A  76     -176.36   -175.79
REMARK 500 12 ARG A 103      122.83   -172.63
REMARK 500 12 ASN A 106      -75.11    -72.93
REMARK 500 12 PRO A 115     -170.44    -69.77
REMARK 500 12 SER A 117      114.04   -179.67
REMARK 500 12 LEU A 130      -95.09    -55.58
REMARK 500 12 ASP A 131      -63.05    168.28
REMARK 500 12 ASN A 145       45.13   -178.37
REMARK 500 12 ASN A 153      -75.95    -51.60
REMARK 500 12 SER A 180      -79.13     67.77
REMARK 500 12 PHE A 202      115.77   -161.66
REMARK 500 12 ASP A 207      -80.30   -179.19
REMARK 500 12 PRO A 211     -163.82    -69.68
REMARK 500 12 GLU A 212      -69.88     73.48
REMARK 500 12 GLN A 214       54.77   -176.18
REMARK 500 12 ASN A 215     -166.19   -125.49
REMARK 500 12 LYS A 219       75.07     89.20
REMARK 500 12 ASN A 222       -4.95     78.66
REMARK 500 12 PHE A 239      -69.74    -99.79
REMARK 500 12 SER A 246      -39.34   -130.09
REMARK 500 12 SER A 248      -77.49    -47.78
REMARK 500 12 THR A 249       12.06   -148.35
REMARK 500 12 GLU A 289      108.66    -56.06
REMARK 500 12 SER A 292       73.19     52.25
REMARK 500 12 PRO A 293       97.49    -69.74
REMARK 500 12 GLU A 294      179.29     63.35
REMARK 500 12 PRO A 299     -176.72    -69.78
REMARK 500 12 ALA A 302      -61.92   -103.67
REMARK 500 12 HIS A 339       44.27    -96.94
REMARK 500 12 HIS A 342       99.49     61.47
REMARK 500 13 LEU A   5      -71.62     70.77
REMARK 500 13 LYS A   6      104.70     63.38
REMARK 500 13 ALA A   7     -168.55   -124.86
REMARK 500 13 GLN A   8       74.14     63.99
REMARK 500 13 ALA A   9       65.62   -179.16
REMARK 500 13 ALA A  13       65.46     66.61
REMARK 500 13 PRO A  14     -166.96    -69.77
REMARK 500 13 CYS A  32      116.71     66.75
REMARK 500 13 ASP A  33      -32.36    176.14
REMARK 500 13 GLN A  35       26.79   -163.82
REMARK 500 13 ALA A  48      -74.02     71.61
REMARK 500 13 THR A  67      -59.79    176.55
REMARK 500 13 VAL A  71      -46.58   -150.40
REMARK 500 13 SER A  75      -75.04    178.07
REMARK 500 13 THR A  76     -174.93   -171.09
REMARK 500 13 MET A  94      108.84    -50.93
REMARK 500 13 ARG A 103      106.83   -175.53
REMARK 500 13 ASN A 106      -75.26    -60.34
REMARK 500 13 HIS A 114       66.28     76.05
REMARK 500 13 PRO A 115     -166.49    -69.77
REMARK 500 13 PHE A 119     -168.56   -107.03
REMARK 500 13 ALA A 120       14.15   -145.20
REMARK 500 13 ASP A 131       89.89    168.71
REMARK 500 13 ASN A 145       68.21   -176.71
REMARK 500 13 SER A 180      -87.44     61.06
REMARK 500 13 PHE A 202      109.75   -170.51
REMARK 500 13 ASP A 207       93.84     63.90
REMARK 500 13 THR A 213      140.63   -171.59
REMARK 500 13 ASN A 222       23.83   -156.28
REMARK 500 13 LEU A 224       97.39    -63.47
REMARK 500 13 GLN A 244      -74.67    -51.57
REMARK 500 13 THR A 247       49.06     36.82
REMARK 500 13 ALA A 269     -175.28    -65.93
REMARK 500 13 SER A 271      131.29   -177.93
REMARK 500 13 GLU A 289       44.23    -92.04
REMARK 500 13 PRO A 293     -170.78    -69.74
REMARK 500 13 GLU A 294     -174.85     63.32
REMARK 500 13 ARG A 295      162.62     63.19
REMARK 500 13 SER A 298       73.92     63.14
REMARK 500 13 PRO A 299       95.86    -69.73
REMARK 500 13 ILE A 301      110.17     64.82
REMARK 500 13 HIS A 340      170.35     62.71
REMARK 500 13 HIS A 341       94.49     62.85
REMARK 500 14 LEU A   2       73.56   -170.68
REMARK 500 14 PRO A   3     -172.02    -69.79
REMARK 500 14 LYS A   6       95.62     58.13
REMARK 500 14 PRO A  14     -170.25    -69.77
REMARK 500 14 CYS A  32     -119.27    173.03
REMARK 500 14 ASP A  33      -63.78     72.54
REMARK 500 14 ASP A  36      -82.78   -173.69
REMARK 500 14 ALA A  37       29.79   -175.96
REMARK 500 14 THR A  67      -57.98    171.49
REMARK 500 14 VAL A  73      -33.37   -160.57
REMARK 500 14 SER A  75      -66.84    172.76
REMARK 500 14 ASP A  89      -67.97   -120.70
REMARK 500 14 SER A  90       60.31     63.73
REMARK 500 14 ARG A  93      -75.13   -101.25
REMARK 500 14 THR A  98      -44.79   -134.45
REMARK 500 14 ARG A 103      116.60   -179.29
REMARK 500 14 ASN A 106      -77.44    -84.83
REMARK 500 14 PRO A 115     -177.50    -69.71
REMARK 500 14 SER A 117      -71.90    -69.08
REMARK 500 14 LEU A 130      -78.84    -48.56
REMARK 500 14 GLN A 133       53.70    179.20
REMARK 500 14 SER A 141      107.30   -161.45
REMARK 500 14 ASN A 145       53.94   -178.49
REMARK 500 14 LEU A 165      -76.46    -58.19
REMARK 500 14 SER A 180      -83.85     62.38
REMARK 500 14 PHE A 202      125.58   -173.67
REMARK 500 14 ASP A 207     -175.65    179.43
REMARK 500 14 TRP A 209       74.70     63.27
REMARK 500 14 GLU A 218       43.37    -78.05
REMARK 500 14 ASN A 222      -34.78   -175.89
REMARK 500 14 PRO A 226        0.34    -69.80
REMARK 500 14 GLN A 243      -74.97    -48.24
REMARK 500 14 GLN A 244      -59.36   -126.91
REMARK 500 14 THR A 249      -22.65    176.35
REMARK 500 14 PRO A 293       78.65    -69.75
REMARK 500 14 GLU A 294     -170.06   -178.49
REMARK 500 14 ALA A 296      105.32     63.52
REMARK 500 14 SER A 298       71.91   -159.76
REMARK 500 14 TRP A 300      -42.96   -167.02
REMARK 500 14 ALA A 302      -62.17    -94.03
REMARK 500 14 ILE A 328      -71.93    -75.51
REMARK 500 14 HIS A 338     -169.85     64.15
REMARK 500 14 HIS A 340      101.32   -164.44
REMARK 500 14 HIS A 341      136.67   -171.12
REMARK 500 15 LYS A   6      -50.24   -159.82
REMARK 500 15 LYS A  15       78.64     51.86
REMARK 500 15 CYS A  32     -169.31   -123.32
REMARK 500 15 ASP A  33       46.58   -100.33
REMARK 500 15 GLN A  35       36.99   -141.57
REMARK 500 15 HIS A  47     -176.53   -179.38
REMARK 500 15 VAL A  71      -51.36   -138.89
REMARK 500 15 SER A  75      -75.06    175.00
REMARK 500 15 GLU A  87     -178.61    178.87
REMARK 500 15 SER A  90      -75.03    -51.77
REMARK 500 15 THR A  91       40.98     38.43
REMARK 500 15 ARG A  92      -69.72   -108.56
REMARK 500 15 GLU A  97     -169.52    -62.09
REMARK 500 15 ARG A 103      117.92   -174.24
REMARK 500 15 ASN A 106      -76.59    -79.63
REMARK 500 15 HIS A 114       71.47   -114.46
REMARK 500 15 PHE A 119     -167.11   -118.46
REMARK 500 15 LEU A 130      -80.45    -56.22
REMARK 500 15 GLN A 133      101.75   -178.75
REMARK 500 15 PRO A 142       57.15    -69.78
REMARK 500 15 ASN A 145       34.97    176.03
REMARK 500 15 GLN A 149      -73.13    -69.13
REMARK 500 15 THR A 150      -74.79   -123.42
REMARK 500 15 ALA A 151      -62.54   -152.61
REMARK 500 15 ASN A 153       17.08     57.41
REMARK 500 15 LEU A 177      118.36   -169.38
REMARK 500 15 SER A 180      -82.00     65.41
REMARK 500 15 PHE A 202      111.22   -173.42
REMARK 500 15 ASP A 207      136.22     73.40
REMARK 500 15 THR A 208     -169.84   -164.96
REMARK 500 15 TRP A 209      -62.43   -174.58
REMARK 500 15 PRO A 211       70.30    -69.73
REMARK 500 15 GLU A 218       43.97    -77.53
REMARK 500 15 ASN A 222      -32.23    178.68
REMARK 500 15 PRO A 226        0.32    -69.71
REMARK 500 15 PHE A 239      -68.67    -97.93
REMARK 500 15 GLN A 244      166.01    179.90
REMARK 500 15 THR A 247      103.43    -49.25
REMARK 500 15 THR A 249      -27.20    172.68
REMARK 500 15 ALA A 283       76.68   -109.32
REMARK 500 15 GLN A 288     -167.97    -68.17
REMARK 500 15 PRO A 293     -174.18    -69.72
REMARK 500 15 ARG A 295     -178.05   -179.09
REMARK 500 15 ALA A 296     -169.32   -173.36
REMARK 500 15 TRP A 297       87.70   -167.69
REMARK 500 15 SER A 298      142.56    179.85
REMARK 500 15 PRO A 299       68.74    -69.74
REMARK 500 15 TRP A 300       85.20    177.53
REMARK 500 15 ASP A 310       93.88    -66.65
REMARK 500 15 HIS A 341     -171.07   -172.78
REMARK 500 15 HIS A 342      -73.92   -133.44
REMARK 500 16 PRO A   3     -179.78    -69.75
REMARK 500 16 LYS A   6      100.44     63.37
REMARK 500 16 ALA A  13      -63.18   -164.06
REMARK 500 16 LYS A  15       91.93     52.01
REMARK 500 16 LEU A  29      -63.44    -90.55
REMARK 500 16 CYS A  32     -177.89     73.20
REMARK 500 16 ASP A  36     -174.28     58.80
REMARK 500 16 ALA A  37      -59.12     74.63
REMARK 500 16 HIS A  47      111.79   -177.98
REMARK 500 16 LEU A  49      -70.65   -144.44
REMARK 500 16 VAL A  71      -56.46   -126.67
REMARK 500 16 SER A  75      -70.47    174.97
REMARK 500 16 THR A  76     -171.97   -175.52
REMARK 500 16 GLU A  88      170.79    -51.98
REMARK 500 16 GLU A  97      -75.32    -85.48
REMARK 500 16 ARG A 103      106.21   -176.41
REMARK 500 16 ASN A 106      -77.91    -93.47
REMARK 500 16 HIS A 114       45.57   -156.47
REMARK 500 16 ALA A 116      -77.46    -51.60
REMARK 500 16 ALA A 120       58.66   -175.37
REMARK 500 16 TRP A 121       51.79    -91.45
REMARK 500 16 LEU A 130     -126.76    -66.53
REMARK 500 16 ASP A 131      -60.01    168.14
REMARK 500 16 PRO A 144       74.49    -69.75
REMARK 500 16 HIS A 161      -70.59    -56.38
REMARK 500 16 GLN A 169       79.71   -112.81
REMARK 500 16 SER A 180      -88.80     53.08
REMARK 500 16 PHE A 202      113.58   -170.32
REMARK 500 16 ASP A 207       88.68     51.58
REMARK 500 16 TRP A 209       71.80     52.20
REMARK 500 16 GLU A 212      -73.81    -98.15
REMARK 500 16 GLN A 214      178.03    -56.29
REMARK 500 16 ASN A 215       78.21     63.41
REMARK 500 16 GLN A 243       37.33   -142.29
REMARK 500 16 GLN A 244      154.47    -49.69
REMARK 500 16 THR A 249      -26.43    172.92
REMARK 500 16 GLN A 288      -58.43   -129.84
REMARK 500 16 SER A 292       72.02   -174.17
REMARK 500 16 ALA A 296       96.55   -172.14
REMARK 500 16 TRP A 297       47.36   -172.86
REMARK 500 16 HIS A 339       71.18     54.25
REMARK 500 16 HIS A 340       92.35    -65.98
REMARK 500 16 HIS A 342      -61.24   -123.67
REMARK 500 17 LEU A   5      108.71    -51.82
REMARK 500 17 LYS A   6      -73.09    -87.47
REMARK 500 17 ALA A   7      135.09   -177.89
REMARK 500 17 ALA A  13      -62.37   -175.09
REMARK 500 17 PRO A  14       76.18    -69.76
REMARK 500 17 CYS A  32     -168.90   -119.53
REMARK 500 17 ASP A  33       44.44   -101.42
REMARK 500 17 GLN A  35       34.51   -143.06
REMARK 500 17 THR A  67      -56.84   -168.27
REMARK 500 17 GLN A  70       89.27     67.32
REMARK 500 17 VAL A  71      159.02    -49.88
REMARK 500 17 MET A  72      -31.51     80.21
REMARK 500 17 SER A  75      -54.70    175.11
REMARK 500 17 THR A  76     -175.74    179.45
REMARK 500 17 ASP A  89     -178.56    -64.90
REMARK 500 17 ARG A 103      104.96   -179.57
REMARK 500 17 PRO A 115     -169.71    -69.80
REMARK 500 17 SER A 117      -72.32    -64.10
REMARK 500 17 ALA A 120       44.44   -105.90
REMARK 500 17 TRP A 121       50.16   -117.33
REMARK 500 17 GLN A 122       14.89   -145.70
REMARK 500 17 TRP A 134     -170.56     42.07
REMARK 500 17 PRO A 142     -178.00    -69.76
REMARK 500 17 PRO A 147       63.89    -69.82
REMARK 500 17 SER A 180      -80.84     63.46
REMARK 500 17 ASP A 207      150.98    175.87
REMARK 500 17 TRP A 209      161.72     62.39
REMARK 500 17 PRO A 211      -86.65    -69.76
REMARK 500 17 GLN A 214      100.17   -179.26
REMARK 500 17 LYS A 219       89.93   -169.68
REMARK 500 17 ASN A 222       48.64    -94.76
REMARK 500 17 GLN A 244     -167.54     54.52
REMARK 500 17 ASP A 275      -74.46   -105.11
REMARK 500 17 SER A 292       73.55     61.92
REMARK 500 17 PRO A 293     -171.51    -69.83
REMARK 500 17 TRP A 297      106.97   -165.45
REMARK 500 17 ILE A 301      -71.56   -121.05
REMARK 500 17 ALA A 302      -62.26   -109.34
REMARK 500 17 ASP A 310       90.37    -69.40
REMARK 500 17 ILE A 325       59.76    -98.24
REMARK 500 17 HIS A 338      -73.57    177.13
REMARK 500 17 HIS A 339       34.85    179.45
REMARK 500 18 LEU A   2       71.88   -119.71
REMARK 500 18 PRO A   3       84.07    -69.78
REMARK 500 18 ALA A   7      152.54     65.27
REMARK 500 18 GLN A   8       98.64     63.45
REMARK 500 18 ALA A   9       66.72   -178.83
REMARK 500 18 PRO A  14     -170.89    -69.74
REMARK 500 18 CYS A  32       -0.67     68.40
REMARK 500 18 ASP A  33       33.17    170.49
REMARK 500 18 GLN A  35       29.61   -156.77
REMARK 500 18 HIS A  47     -169.32    179.03
REMARK 500 18 LEU A  49      -39.82   -158.27
REMARK 500 18 PRO A  68       63.68    -69.75
REMARK 500 18 VAL A  73      -58.00   -120.30
REMARK 500 18 ALA A  86      -76.11    -70.74
REMARK 500 18 THR A  91       97.51   -165.83
REMARK 500 18 MET A  94      -75.66   -130.40
REMARK 500 18 PRO A 115      -87.33    -69.72
REMARK 500 18 ALA A 120      103.27    -51.73
REMARK 500 18 TRP A 121      106.38    -31.01
REMARK 500 18 GLN A 122       44.37    -87.16
REMARK 500 18 GLN A 133      -39.99   -139.21
REMARK 500 18 TRP A 134      172.42    -52.27
REMARK 500 18 SER A 141      108.80   -166.09
REMARK 500 18 PRO A 147      -86.86    -69.73
REMARK 500 18 ASN A 153      -76.65    -52.54
REMARK 500 18 GLU A 156      -70.40    -61.12
REMARK 500 18 HIS A 161      -72.59    -61.32
REMARK 500 18 PRO A 170        3.68    -69.72
REMARK 500 18 SER A 180      -84.42     61.82
REMARK 500 18 PHE A 202      114.61   -170.07
REMARK 500 18 ASP A 207      109.38     64.08
REMARK 500 18 THR A 208       49.59   -168.73
REMARK 500 18 GLU A 212       81.51   -166.86
REMARK 500 18 GLU A 218       47.04    -87.87
REMARK 500 18 PHE A 239      -66.08    -98.15
REMARK 500 18 GLN A 244      -74.45    -69.10
REMARK 500 18 SER A 248      -76.03    -51.31
REMARK 500 18 THR A 249       11.77   -142.75
REMARK 500 18 GLN A 288      -74.39    -56.83
REMARK 500 18 GLU A 289       86.19   -179.45
REMARK 500 18 ALA A 296       87.23     57.93
REMARK 500 18 SER A 298       69.04   -118.97
REMARK 500 18 TRP A 300      -73.07   -132.61
REMARK 500 18 HIS A 339      170.64     63.16
REMARK 500 18 HIS A 340      -68.93   -120.16
REMARK 500 18 HIS A 342      -52.71   -122.55
REMARK 500 19 LYS A   6      104.32   -167.18
REMARK 500 19 ALA A   7      130.68   -175.08
REMARK 500 19 GLN A   8      156.42     64.45
REMARK 500 19 ALA A  13       64.84     67.10
REMARK 500 19 LYS A  15       34.31    176.20
REMARK 500 19 ASP A  36     -169.07   -178.27
REMARK 500 19 HIS A  47     -171.86    177.65
REMARK 500 19 THR A  67      -58.62    174.05
REMARK 500 19 PRO A  68       85.01    -69.76
REMARK 500 19 VAL A  71      -55.01   -151.75
REMARK 500 19 SER A  75      -66.48    169.79
REMARK 500 19 THR A  76     -171.24   -174.08
REMARK 500 19 ALA A  86       80.62   -178.54
REMARK 500 19 GLU A  88      -73.98    -53.56
REMARK 500 19 ASN A 106      -78.33   -108.41
REMARK 500 19 SER A 135       96.38    -56.25
REMARK 500 19 SER A 141      108.49   -160.69
REMARK 500 19 ASN A 145       48.09   -175.44
REMARK 500 19 GLN A 169       75.89   -156.11
REMARK 500 19 SER A 180      -81.10     63.59
REMARK 500 19 PHE A 202      131.12   -173.30
REMARK 500 19 ASP A 207     -162.10     63.77
REMARK 500 19 TRP A 209      161.89     60.74
REMARK 500 19 GLU A 212      -54.35   -133.84
REMARK 500 19 THR A 213      -43.74   -142.45
REMARK 500 19 ASN A 222      -34.14   -179.95
REMARK 500 19 THR A 249      -58.55     75.12
REMARK 500 19 ALA A 269     -177.75    -57.26
REMARK 500 19 ASP A 275       61.42   -114.39
REMARK 500 19 GLN A 288      -67.76   -155.34
REMARK 500 19 SER A 292       69.45   -162.21
REMARK 500 19 ARG A 295      -67.60   -139.16
REMARK 500 19 ILE A 301      -72.02   -122.59
REMARK 500 19 ALA A 302      -61.95   -109.77
REMARK 500 19 GLU A 303      119.06   -164.93
REMARK 500 19 HIS A 338      -72.60   -172.91
REMARK 500 19 HIS A 339       48.08   -170.34
REMARK 500 19 HIS A 341      172.11    -59.72
REMARK 500 20 ALA A   7     -169.61   -163.69
REMARK 500 20 ALA A  13       66.15    179.04
REMARK 500 20 PRO A  14       94.56    -69.72
REMARK 500 20 LYS A  15       28.76   -172.56
REMARK 500 20 GLN A  35      -79.10    -38.34
REMARK 500 20 ASP A  36      -80.45    168.76
REMARK 500 20 HIS A  47      157.73     66.90
REMARK 500 20 ALA A  48      -80.63     69.86
REMARK 500 20 THR A  67      -56.73   -169.44
REMARK 500 20 GLN A  70      -47.12     75.26
REMARK 500 20 VAL A  71      -67.47     68.63
REMARK 500 20 SER A  75      -59.03    169.42
REMARK 500 20 ASP A  85      -54.41   -125.56
REMARK 500 20 ALA A  86     -162.42    -73.09
REMARK 500 20 ARG A  93      148.63   -179.44
REMARK 500 20 MET A  94      126.44   -171.00
REMARK 500 20 THR A  98      -52.48   -124.48
REMARK 500 20 ARG A 103      103.89   -161.57
REMARK 500 20 PRO A 115     -168.90    -69.75
REMARK 500 20 SER A 117      118.54   -163.90
REMARK 500 20 ASP A 131       89.87    169.08
REMARK 500 20 SER A 141      108.00   -165.56
REMARK 500 20 HIS A 161      -72.22    -51.71
REMARK 500 20 GLN A 169       77.22   -153.51
REMARK 500 20 SER A 180      -80.62     64.22
REMARK 500 20 PHE A 202      115.10   -172.39
REMARK 500 20 ASP A 207      135.59     67.10
REMARK 500 20 THR A 208      -75.03   -161.47
REMARK 500 20 GLU A 212      162.44    -49.92
REMARK 500 20 ASN A 222       40.21    -96.77
REMARK 500 20 PRO A 226        0.06    -69.73
REMARK 500 20 GLN A 243       37.04   -145.17
REMARK 500 20 THR A 249       17.14   -148.60
REMARK 500 20 ASP A 275       70.95   -113.70
REMARK 500 20 GLN A 288       37.79   -160.22
REMARK 500 20 SER A 292       70.73     51.61
REMARK 500 20 GLU A 294       85.79    178.99
REMARK 500 20 ARG A 295      -76.23   -167.19
REMARK 500 20 ALA A 296     -169.82     51.31
REMARK 500 20 TRP A 297       80.20     60.99
REMARK 500 20 SER A 298      159.36    179.90
REMARK 500 20 ASP A 310       93.61    -67.22
REMARK 500 20 HIS A 338      -68.59   -164.13
REMARK 500 20 HIS A 339       96.07   -168.25
REMARK 500
REMARK 500 REMARK: NULL
DBREF  2ROQ A    2   335  UNP    P11454   ENTF_ECOLI     960   1293
SEQADV 2ROQ MET A    1  UNP  P11454              EXPRESSION TAG
SEQADV 2ROQ ALA A   48  UNP  P11454    SER  1006 ENGINEERED
SEQADV 2ROQ LEU A  336  UNP  P11454              EXPRESSION TAG
SEQADV 2ROQ GLU A  337  UNP  P11454              EXPRESSION TAG
SEQADV 2ROQ HIS A  338  UNP  P11454              EXPRESSION TAG
SEQADV 2ROQ HIS A  339  UNP  P11454              EXPRESSION TAG
SEQADV 2ROQ HIS A  340  UNP  P11454              EXPRESSION TAG
SEQADV 2ROQ HIS A  341  UNP  P11454              EXPRESSION TAG
SEQADV 2ROQ HIS A  342  UNP  P11454              EXPRESSION TAG
SEQADV 2ROQ HIS A  343  UNP  P11454              EXPRESSION TAG
SEQRES   1 A  343  MET LEU PRO GLU LEU LYS ALA GLN ALA PRO GLY ARG ALA
SEQRES   2 A  343  PRO LYS ALA GLY SER GLU THR ILE ILE ALA ALA ALA PHE
SEQRES   3 A  343  SER SER LEU LEU GLY CYS ASP VAL GLN ASP ALA ASP ALA
SEQRES   4 A  343  ASP PHE PHE ALA LEU GLY GLY HIS ALA LEU LEU ALA MET
SEQRES   5 A  343  LYS LEU ALA ALA GLN LEU SER ARG GLN VAL ALA ARG GLN
SEQRES   6 A  343  VAL THR PRO GLY GLN VAL MET VAL ALA SER THR VAL ALA
SEQRES   7 A  343  LYS LEU ALA THR ILE ILE ASP ALA GLU GLU ASP SER THR
SEQRES   8 A  343  ARG ARG MET GLY PHE GLU THR ILE LEU PRO LEU ARG GLU
SEQRES   9 A  343  GLY ASN GLY PRO THR LEU PHE CYS PHE HIS PRO ALA SER
SEQRES  10 A  343  GLY PHE ALA TRP GLN PHE SER VAL LEU SER ARG TYR LEU
SEQRES  11 A  343  ASP PRO GLN TRP SER ILE ILE GLY ILE GLN SER PRO ARG
SEQRES  12 A  343  PRO ASN GLY PRO MET GLN THR ALA ALA ASN LEU ASP GLU
SEQRES  13 A  343  VAL CYS GLU ALA HIS LEU ALA THR LEU LEU GLU GLN GLN
SEQRES  14 A  343  PRO HIS GLY PRO TYR TYR LEU LEU GLY TYR SER LEU GLY
SEQRES  15 A  343  GLY THR LEU ALA GLN GLY ILE ALA ALA ARG LEU ARG ALA
SEQRES  16 A  343  ARG GLY GLU GLN VAL ALA PHE LEU GLY LEU LEU ASP THR
SEQRES  17 A  343  TRP PRO PRO GLU THR GLN ASN TRP GLN GLU LYS GLU ALA
SEQRES  18 A  343  ASN GLY LEU ASP PRO GLU VAL LEU ALA GLU ILE ASN ARG
SEQRES  19 A  343  GLU ARG GLU ALA PHE LEU ALA ALA GLN GLN GLY SER THR
SEQRES  20 A  343  SER THR GLU LEU PHE THR THR ILE GLU GLY ASN TYR ALA
SEQRES  21 A  343  ASP ALA VAL ARG LEU LEU THR THR ALA HIS SER VAL PRO
SEQRES  22 A  343  PHE ASP GLY LYS ALA THR LEU PHE VAL ALA GLU ARG THR
SEQRES  23 A  343  LEU GLN GLU GLY MET SER PRO GLU ARG ALA TRP SER PRO
SEQRES  24 A  343  TRP ILE ALA GLU LEU ASP ILE TYR ARG GLN ASP CYS ALA
SEQRES  25 A  343  HIS VAL ASP ILE ILE SER PRO GLY THR PHE GLU LYS ILE
SEQRES  26 A  343  GLY PRO ILE ILE ARG ALA THR LEU ASN ARG LEU GLU HIS
SEQRES  27 A  343  HIS HIS HIS HIS HIS
HELIX    1   1 GLY A   17  LEU A   30  1                                  14
HELIX    2   2 ASP A   40  GLY A   45  1                                   6
HELIX    3   3 LEU A   49  VAL A   62  1                                  14
HELIX    4   4 THR A   76  ASP A   85  1                                  10
HELIX    5   5 PHE A  123  ASP A  131  1                                   9
HELIX    6   6 ALA A  152  GLN A  169  1                                  18
HELIX    7   7 LEU A  181  GLY A  197  1                                  17
HELIX    8   8 ASN A  215  GLY A  223  5                                   9
HELIX    9   9 GLU A  227  LEU A  240  1                                  14
HELIX   10  10 THR A  249  LEU A  266  1                                  18
HELIX   11  11 ARG A  285  LEU A  287  5                                   3
HELIX   12  12 SER A  318  ILE A  325  1                                   8
HELIX   13  13 PRO A  327  HIS A  338  1                                  12
SHEET    1   A 7 LEU A 100  ARG A 103  0
SHEET    2   A 7 SER A 135  GLY A 138 -1  O  ILE A 136   N  ARG A 103
SHEET    3   A 7 THR A 109  CYS A 112  1  N  LEU A 110   O  SER A 135
SHEET    4   A 7 TYR A 175  TYR A 179  1  O  LEU A 177   N  PHE A 111
SHEET    5   A 7 PHE A 202  LEU A 206  1  O  GLY A 204   N  LEU A 176
SHEET    6   A 7 LYS A 277  ALA A 283  1  O  THR A 279   N  LEU A 205
SHEET    7   A 7 GLU A 303  GLN A 309  1  O  TYR A 307   N  VAL A 282
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      1.000000  0.000000  0.000000        0.00000
SCALE2      0.000000  1.000000  0.000000        0.00000
SCALE3      0.000000  0.000000  1.000000        0.00000
MODEL        1
TER    5228      HIS A 343
ENDMDL
MODEL        2
TER    5228      HIS A 343
ENDMDL
MODEL        3
TER    5228      HIS A 343
ENDMDL
MODEL        4
TER    5228      HIS A 343
ENDMDL
MODEL        5
TER    5228      HIS A 343
ENDMDL
MODEL        6
TER    5228      HIS A 343
ENDMDL
MODEL        7
TER    5228      HIS A 343
ENDMDL
MODEL        8
TER    5228      HIS A 343
ENDMDL
MODEL        9
TER    5228      HIS A 343
ENDMDL
MODEL       10
TER    5228      HIS A 343
ENDMDL
MODEL       11
TER    5228      HIS A 343
ENDMDL
MODEL       12
TER    5228      HIS A 343
ENDMDL
MODEL       13
TER    5228      HIS A 343
ENDMDL
MODEL       14
TER    5228      HIS A 343
ENDMDL
MODEL       15
TER    5228      HIS A 343
ENDMDL
MODEL       16
TER    5228      HIS A 343
ENDMDL
MODEL       17
TER    5228      HIS A 343
ENDMDL
MODEL       18
TER    5228      HIS A 343
ENDMDL
MODEL       19
TER    5228      HIS A 343
ENDMDL
MODEL       20
TER    5228      HIS A 343
ENDMDL
MASTER      974    0    0   13    7    0    0    610454   20    0   27
END