longtext: 2VAT-pdb

content
HEADER    TRANSFERASE                             04-SEP-07   2VAT
TITLE     CRYSTAL STRUCTURE OF DEACETYLCEPHALOSPORIN C
TITLE    2 ACETYLTRANSFERASE IN COMPLEX WITH COENZYME A
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: ACETYL-COA--DEACETYLCEPHALOSPORIN C
COMPND   3  ACETYLTRANSFERASE;
COMPND   4 CHAIN: A, B, C, D, E, F, G, H, I, J, K, L;
COMPND   5 SYNONYM: DCPC-ATF, DAC ACETYLTRANSFERASE, DAC-AT,
COMPND   6  DEACETYLCEPHALOSPORIN C ACETYLTRANSFERASE;
COMPND   7 EC: 2.3.1.175;
COMPND   8 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: ACREMONIUM CHRYSOGENUM;
SOURCE   3 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   4 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);
SOURCE   5 EXPRESSION_SYSTEM_PLASMID: PTWIN
KEYWDS    ACETYL TRANSFERASE, A/B- HYDROLASE FOLD, TRANSFERASE,
KEYWDS   2 ACYLTRANSFERASE, ACETYL COENZYME A, ANTIBIOTIC
KEYWDS   3 BIOSYNTHESIS, CEPHALOSPORIN BIOSYNTHESIS
EXPDTA    X-RAY DIFFRACTION
AUTHOR    S.LEJON,J.ELLIS,K.VALEGARD
REVDAT   1   23-SEP-08 2VAT    0
JRNL        AUTH   S.LEJON,J.ELLIS,K.VALEGARD
JRNL        TITL   THE LAST STEP IN CEPHALOSPORIN C FORMATION
JRNL        TITL 2 REVEALED: CRYSTAL STRUCTURES OF
JRNL        TITL 3 DEACETYLCEPHALOSPORIN C ACETYLTRANSFERASE FROM
JRNL        TITL 4 ACREMONIUM CHRYSOGENUM IN COMPLEXES WITH REACTION
JRNL        TITL 5 INTERMEDIATES.
JRNL        REF    J.MOL.BIOL.                   V. 377   935 2008
JRNL        REFN   ASTM JMOBAK  UK ISSN 0022-2836
REMARK   2
REMARK   2 RESOLUTION. 2.2  ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.2.0019
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3   REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.20
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 122.17
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NONE
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.53
REMARK   3   NUMBER OF REFLECTIONS             : 253887
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.20063
REMARK   3   R VALUE            (WORKING SET) : 0.20006
REMARK   3   FREE R VALUE                     : 0.23034
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 1.7
REMARK   3   FREE R VALUE TEST SET COUNT      : 4405
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.200
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.257
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 18133
REMARK   3   BIN R VALUE           (WORKING SET) : 0.243
REMARK   3   BIN FREE R VALUE SET COUNT          : 321
REMARK   3   BIN FREE R VALUE                    : 0.308
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 32804
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 636
REMARK   3   SOLVENT ATOMS            :   1573
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 24.458
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -0.86
REMARK   3    B22 (A**2) : 2.10
REMARK   3    B33 (A**2) : -1.24
REMARK   3    B12 (A**2) : 0.00
REMARK   3    B13 (A**2) : -0.09
REMARK   3    B23 (A**2) : 0.00
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.247
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.190
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.144
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 5.616
REMARK   3
REMARK   3  CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.937
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.913
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES    COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED           (A): 34275 ; 0.019 ; 0.022
REMARK   3   BOND LENGTHS OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   BOND ANGLES REFINED      (DEGREES): 46567 ; 1.435 ; 1.960
REMARK   3   BOND ANGLES OTHERS       (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   TORSION ANGLES, PERIOD 1 (DEGREES):  4170 ; 6.223 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2 (DEGREES):  1650 ;30.782 ;22.582
REMARK   3   TORSION ANGLES, PERIOD 3 (DEGREES):  5393 ;15.607 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4 (DEGREES):   342 ;18.729 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS    (A**3):  4929 ; 0.126 ; 0.200
REMARK   3   GENERAL PLANES REFINED         (A): 26450 ; 0.007 ; 0.020
REMARK   3   GENERAL PLANES OTHERS          (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS REFINED    (A): 15329 ; 0.207 ; 0.200
REMARK   3   NON-BONDED CONTACTS OTHERS     (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED     (A): 23387 ; 0.310 ; 0.200
REMARK   3   NON-BONDED TORSION OTHERS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED         (A):  1832 ; 0.173 ; 0.200
REMARK   3   SYMMETRY VDW REFINED           (A):   274 ; 0.233 ; 0.200
REMARK   3   SYMMETRY VDW OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED        (A):    47 ; 0.281 ; 0.200
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT  RMS   WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED   (A**2): 21221 ; 1.087 ; 1.500
REMARK   3   MAIN-CHAIN ANGLE REFINED  (A**2): 33347 ; 1.731 ; 2.000
REMARK   3   SIDE-CHAIN BOND REFINED   (A**2): 14840 ; 2.749 ; 3.000
REMARK   3   SIDE-CHAIN ANGLE REFINED  (A**2): 13186 ; 4.321 ; 4.500
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF NCS GROUPS : 10
REMARK   3
REMARK   3  NCS GROUP NUMBER               :   1
REMARK   3     CHAIN NAMES                    : A B C D E F G H I J K L
REMARK   3     NUMBER OF COMPONENTS NCS GROUP :    1
REMARK   3       COMPONENT C  SSSEQI  TO  C   SSSEQI   CODE
REMARK   3           1     A      7       A      32      1
REMARK   3           1     B      7       B      32      1
REMARK   3           1     C      7       C      32      1
REMARK   3           1     D      7       D      32      1
REMARK   3           1     E      7       E      32      1
REMARK   3           1     F      7       F      32      1
REMARK   3           1     G      7       G      32      1
REMARK   3           1     H      7       H      32      1
REMARK   3           1     I      7       I      32      1
REMARK   3           1     J      7       J      32      1
REMARK   3           1     K      7       K      32      1
REMARK   3           1     L      7       L      32      1
REMARK   3                   GROUP CHAIN        COUNT   RMS     WEIGHT
REMARK   3   TIGHT POSITIONAL   1    A    (A):    194 ;   .08 ;   .05
REMARK   3   TIGHT POSITIONAL   1    B    (A):    194 ;   .22 ;   .05
REMARK   3   TIGHT POSITIONAL   1    C    (A):    194 ;   .09 ;   .05
REMARK   3   TIGHT POSITIONAL   1    D    (A):    194 ;   .18 ;   .05
REMARK   3   TIGHT POSITIONAL   1    E    (A):    194 ;   .09 ;   .05
REMARK   3   TIGHT POSITIONAL   1    F    (A):    194 ;   .08 ;   .05
REMARK   3   TIGHT POSITIONAL   1    G    (A):    194 ;   .09 ;   .05
REMARK   3   TIGHT POSITIONAL   1    H    (A):    194 ;   .10 ;   .05
REMARK   3   TIGHT POSITIONAL   1    I    (A):    194 ;   .09 ;   .05
REMARK   3   TIGHT POSITIONAL   1    J    (A):    194 ;   .17 ;   .05
REMARK   3   TIGHT POSITIONAL   1    K    (A):    194 ;   .09 ;   .05
REMARK   3   TIGHT POSITIONAL   1    L    (A):    194 ;   .08 ;   .05
REMARK   3   TIGHT THERMAL      1    A (A**2):    194 ;   .46 ;   .50
REMARK   3   TIGHT THERMAL      1    B (A**2):    194 ;   .48 ;   .50
REMARK   3   TIGHT THERMAL      1    C (A**2):    194 ;   .25 ;   .50
REMARK   3   TIGHT THERMAL      1    D (A**2):    194 ;   .26 ;   .50
REMARK   3   TIGHT THERMAL      1    E (A**2):    194 ;   .47 ;   .50
REMARK   3   TIGHT THERMAL      1    F (A**2):    194 ;   .40 ;   .50
REMARK   3   TIGHT THERMAL      1    G (A**2):    194 ;   .23 ;   .50
REMARK   3   TIGHT THERMAL      1    H (A**2):    194 ;   .24 ;   .50
REMARK   3   TIGHT THERMAL      1    I (A**2):    194 ;   .49 ;   .50
REMARK   3   TIGHT THERMAL      1    J (A**2):    194 ;   .67 ;   .50
REMARK   3   TIGHT THERMAL      1    K (A**2):    194 ;   .63 ;   .50
REMARK   3   TIGHT THERMAL      1    L (A**2):    194 ;   .40 ;   .50
REMARK   3
REMARK   3  NCS GROUP NUMBER               :   2
REMARK   3     CHAIN NAMES                    : A B C D E F G H I J K L
REMARK   3     NUMBER OF COMPONENTS NCS GROUP :    1
REMARK   3       COMPONENT C  SSSEQI  TO  C   SSSEQI   CODE
REMARK   3           1     A     35       A      46      1
REMARK   3           1     B     35       B      46      1
REMARK   3           1     C     35       C      46      1
REMARK   3           1     D     35       D      46      1
REMARK   3           1     E     35       E      46      1
REMARK   3           1     F     35       F      46      1
REMARK   3           1     G     35       G      46      1
REMARK   3           1     H     35       H      46      1
REMARK   3           1     I     35       I      46      1
REMARK   3           1     J     35       J      46      1
REMARK   3           1     K     35       K      46      1
REMARK   3           1     L     35       L      46      1
REMARK   3                   GROUP CHAIN        COUNT   RMS     WEIGHT
REMARK   3   TIGHT POSITIONAL   2    A    (A):     98 ;   .06 ;   .05
REMARK   3   TIGHT POSITIONAL   2    B    (A):     98 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL   2    C    (A):     98 ;   .06 ;   .05
REMARK   3   TIGHT POSITIONAL   2    D    (A):     98 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL   2    E    (A):     98 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL   2    F    (A):     98 ;   .08 ;   .05
REMARK   3   TIGHT POSITIONAL   2    G    (A):     98 ;   .08 ;   .05
REMARK   3   TIGHT POSITIONAL   2    H    (A):     98 ;   .09 ;   .05
REMARK   3   TIGHT POSITIONAL   2    I    (A):     98 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL   2    J    (A):     98 ;   .08 ;   .05
REMARK   3   TIGHT POSITIONAL   2    K    (A):     98 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL   2    L    (A):     98 ;   .08 ;   .05
REMARK   3   TIGHT THERMAL      2    A (A**2):     98 ;   .34 ;   .50
REMARK   3   TIGHT THERMAL      2    B (A**2):     98 ;   .35 ;   .50
REMARK   3   TIGHT THERMAL      2    C (A**2):     98 ;   .38 ;   .50
REMARK   3   TIGHT THERMAL      2    D (A**2):     98 ;   .38 ;   .50
REMARK   3   TIGHT THERMAL      2    E (A**2):     98 ;   .31 ;   .50
REMARK   3   TIGHT THERMAL      2    F (A**2):     98 ;   .32 ;   .50
REMARK   3   TIGHT THERMAL      2    G (A**2):     98 ;   .36 ;   .50
REMARK   3   TIGHT THERMAL      2    H (A**2):     98 ;   .33 ;   .50
REMARK   3   TIGHT THERMAL      2    I (A**2):     98 ;   .37 ;   .50
REMARK   3   TIGHT THERMAL      2    J (A**2):     98 ;   .72 ;   .50
REMARK   3   TIGHT THERMAL      2    K (A**2):     98 ;   .66 ;   .50
REMARK   3   TIGHT THERMAL      2    L (A**2):     98 ;   .31 ;   .50
REMARK   3
REMARK   3  NCS GROUP NUMBER               :   3
REMARK   3     CHAIN NAMES                    : A B C D E F G H I J K L
REMARK   3     NUMBER OF COMPONENTS NCS GROUP :    1
REMARK   3       COMPONENT C  SSSEQI  TO  C   SSSEQI   CODE
REMARK   3           1     A     48       A     127      1
REMARK   3           1     B     48       B     127      1
REMARK   3           1     C     48       C     127      1
REMARK   3           1     D     48       D     127      1
REMARK   3           1     E     48       E     127      1
REMARK   3           1     F     48       F     127      1
REMARK   3           1     G     48       G     127      1
REMARK   3           1     H     48       H     127      1
REMARK   3           1     I     48       I     127      1
REMARK   3           1     J     48       J     127      1
REMARK   3           1     K     48       K     127      1
REMARK   3           1     L     48       L     127      1
REMARK   3                   GROUP CHAIN        COUNT   RMS     WEIGHT
REMARK   3   TIGHT POSITIONAL   3    A    (A):    557 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL   3    B    (A):    557 ;   .06 ;   .05
REMARK   3   TIGHT POSITIONAL   3    C    (A):    557 ;   .09 ;   .05
REMARK   3   TIGHT POSITIONAL   3    D    (A):    557 ;   .09 ;   .05
REMARK   3   TIGHT POSITIONAL   3    E    (A):    557 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL   3    F    (A):    557 ;   .08 ;   .05
REMARK   3   TIGHT POSITIONAL   3    G    (A):    557 ;   .09 ;   .05
REMARK   3   TIGHT POSITIONAL   3    H    (A):    557 ;   .09 ;   .05
REMARK   3   TIGHT POSITIONAL   3    I    (A):    557 ;   .06 ;   .05
REMARK   3   TIGHT POSITIONAL   3    J    (A):    557 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL   3    K    (A):    557 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL   3    L    (A):    557 ;   .08 ;   .05
REMARK   3   TIGHT THERMAL      3    A (A**2):    557 ;   .34 ;   .50
REMARK   3   TIGHT THERMAL      3    B (A**2):    557 ;   .41 ;   .50
REMARK   3   TIGHT THERMAL      3    C (A**2):    557 ;   .36 ;   .50
REMARK   3   TIGHT THERMAL      3    D (A**2):    557 ;   .33 ;   .50
REMARK   3   TIGHT THERMAL      3    E (A**2):    557 ;   .35 ;   .50
REMARK   3   TIGHT THERMAL      3    F (A**2):    557 ;   .33 ;   .50
REMARK   3   TIGHT THERMAL      3    G (A**2):    557 ;   .29 ;   .50
REMARK   3   TIGHT THERMAL      3    H (A**2):    557 ;   .31 ;   .50
REMARK   3   TIGHT THERMAL      3    I (A**2):    557 ;   .40 ;   .50
REMARK   3   TIGHT THERMAL      3    J (A**2):    557 ;   .70 ;   .50
REMARK   3   TIGHT THERMAL      3    K (A**2):    557 ;   .65 ;   .50
REMARK   3   TIGHT THERMAL      3    L (A**2):    557 ;   .33 ;   .50
REMARK   3
REMARK   3  NCS GROUP NUMBER               :   4
REMARK   3     CHAIN NAMES                    : A B C D E F G H I J K L
REMARK   3     NUMBER OF COMPONENTS NCS GROUP :    1
REMARK   3       COMPONENT C  SSSEQI  TO  C   SSSEQI   CODE
REMARK   3           1     A    129       A     139      1
REMARK   3           1     B    129       B     139      1
REMARK   3           1     C    129       C     139      1
REMARK   3           1     D    129       D     139      1
REMARK   3           1     E    129       E     139      1
REMARK   3           1     F    129       F     139      1
REMARK   3           1     G    129       G     139      1
REMARK   3           1     H    129       H     139      1
REMARK   3           1     I    129       I     139      1
REMARK   3           1     J    129       J     139      1
REMARK   3           1     K    129       K     139      1
REMARK   3           1     L    129       L     139      1
REMARK   3                   GROUP CHAIN        COUNT   RMS     WEIGHT
REMARK   3   TIGHT POSITIONAL   4    A    (A):     75 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL   4    B    (A):     75 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL   4    C    (A):     75 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL   4    D    (A):     75 ;   .08 ;   .05
REMARK   3   TIGHT POSITIONAL   4    E    (A):     75 ;   .06 ;   .05
REMARK   3   TIGHT POSITIONAL   4    F    (A):     75 ;   .09 ;   .05
REMARK   3   TIGHT POSITIONAL   4    G    (A):     75 ;   .09 ;   .05
REMARK   3   TIGHT POSITIONAL   4    H    (A):     75 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL   4    I    (A):     75 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL   4    J    (A):     75 ;   .10 ;   .05
REMARK   3   TIGHT POSITIONAL   4    K    (A):     75 ;   .10 ;   .05
REMARK   3   TIGHT POSITIONAL   4    L    (A):     75 ;   .09 ;   .05
REMARK   3   TIGHT THERMAL      4    A (A**2):     75 ;   .38 ;   .50
REMARK   3   TIGHT THERMAL      4    B (A**2):     75 ;   .55 ;   .50
REMARK   3   TIGHT THERMAL      4    C (A**2):     75 ;   .35 ;   .50
REMARK   3   TIGHT THERMAL      4    D (A**2):     75 ;   .34 ;   .50
REMARK   3   TIGHT THERMAL      4    E (A**2):     75 ;   .36 ;   .50
REMARK   3   TIGHT THERMAL      4    F (A**2):     75 ;   .29 ;   .50
REMARK   3   TIGHT THERMAL      4    G (A**2):     75 ;   .30 ;   .50
REMARK   3   TIGHT THERMAL      4    H (A**2):     75 ;   .29 ;   .50
REMARK   3   TIGHT THERMAL      4    I (A**2):     75 ;   .51 ;   .50
REMARK   3   TIGHT THERMAL      4    J (A**2):     75 ;   .75 ;   .50
REMARK   3   TIGHT THERMAL      4    K (A**2):     75 ;   .71 ;   .50
REMARK   3   TIGHT THERMAL      4    L (A**2):     75 ;   .32 ;   .50
REMARK   3
REMARK   3  NCS GROUP NUMBER               :   5
REMARK   3     CHAIN NAMES                    : A B C D E F G H I J K L
REMARK   3     NUMBER OF COMPONENTS NCS GROUP :    1
REMARK   3       COMPONENT C  SSSEQI  TO  C   SSSEQI   CODE
REMARK   3           1     A    141       A     268      1
REMARK   3           1     B    141       B     268      1
REMARK   3           1     C    141       C     268      1
REMARK   3           1     D    141       D     268      1
REMARK   3           1     E    141       E     268      1
REMARK   3           1     F    141       F     268      1
REMARK   3           1     G    141       G     268      1
REMARK   3           1     H    141       H     268      1
REMARK   3           1     I    141       I     268      1
REMARK   3           1     J    141       J     268      1
REMARK   3           1     K    141       K     268      1
REMARK   3           1     L    141       L     268      1
REMARK   3                   GROUP CHAIN        COUNT   RMS     WEIGHT
REMARK   3   TIGHT POSITIONAL   5    A    (A):    757 ;   .12 ;   .05
REMARK   3   TIGHT POSITIONAL   5    B    (A):    757 ;   .18 ;   .05
REMARK   3   TIGHT POSITIONAL   5    C    (A):    757 ;   .17 ;   .05
REMARK   3   TIGHT POSITIONAL   5    D    (A):    757 ;   .11 ;   .05
REMARK   3   TIGHT POSITIONAL   5    E    (A):    757 ;   .10 ;   .05
REMARK   3   TIGHT POSITIONAL   5    F    (A):    757 ;   .16 ;   .05
REMARK   3   TIGHT POSITIONAL   5    G    (A):    757 ;   .11 ;   .05
REMARK   3   TIGHT POSITIONAL   5    H    (A):    757 ;   .11 ;   .05
REMARK   3   TIGHT POSITIONAL   5    I    (A):    757 ;   .10 ;   .05
REMARK   3   TIGHT POSITIONAL   5    J    (A):    757 ;   .11 ;   .05
REMARK   3   TIGHT POSITIONAL   5    K    (A):    757 ;   .10 ;   .05
REMARK   3   TIGHT POSITIONAL   5    L    (A):    757 ;   .09 ;   .05
REMARK   3   TIGHT THERMAL      5    A (A**2):    757 ;   .37 ;   .50
REMARK   3   TIGHT THERMAL      5    B (A**2):    757 ;   .36 ;   .50
REMARK   3   TIGHT THERMAL      5    C (A**2):    757 ;   .28 ;   .50
REMARK   3   TIGHT THERMAL      5    D (A**2):    757 ;   .28 ;   .50
REMARK   3   TIGHT THERMAL      5    E (A**2):    757 ;   .35 ;   .50
REMARK   3   TIGHT THERMAL      5    F (A**2):    757 ;   .28 ;   .50
REMARK   3   TIGHT THERMAL      5    G (A**2):    757 ;   .27 ;   .50
REMARK   3   TIGHT THERMAL      5    H (A**2):    757 ;   .27 ;   .50
REMARK   3   TIGHT THERMAL      5    I (A**2):    757 ;   .37 ;   .50
REMARK   3   TIGHT THERMAL      5    J (A**2):    757 ;   .49 ;   .50
REMARK   3   TIGHT THERMAL      5    K (A**2):    757 ;   .47 ;   .50
REMARK   3   TIGHT THERMAL      5    L (A**2):    757 ;   .29 ;   .50
REMARK   3
REMARK   3  NCS GROUP NUMBER               :   6
REMARK   3     CHAIN NAMES                    : A B C D E F G H I J K L
REMARK   3     NUMBER OF COMPONENTS NCS GROUP :    1
REMARK   3       COMPONENT C  SSSEQI  TO  C   SSSEQI   CODE
REMARK   3           1     A    272       A     309      1
REMARK   3           1     B    272       B     309      1
REMARK   3           1     C    272       C     309      1
REMARK   3           1     D    272       D     309      1
REMARK   3           1     E    272       E     309      1
REMARK   3           1     F    272       F     309      1
REMARK   3           1     G    272       G     309      1
REMARK   3           1     H    272       H     309      1
REMARK   3           1     I    272       I     309      1
REMARK   3           1     J    272       J     309      1
REMARK   3           1     K    272       K     309      1
REMARK   3           1     L    272       L     309      1
REMARK   3                   GROUP CHAIN        COUNT   RMS     WEIGHT
REMARK   3   TIGHT POSITIONAL   6    A    (A):    295 ;   .09 ;   .05
REMARK   3   TIGHT POSITIONAL   6    B    (A):    295 ;   .09 ;   .05
REMARK   3   TIGHT POSITIONAL   6    C    (A):    295 ;   .10 ;   .05
REMARK   3   TIGHT POSITIONAL   6    D    (A):    295 ;   .10 ;   .05
REMARK   3   TIGHT POSITIONAL   6    E    (A):    295 ;   .09 ;   .05
REMARK   3   TIGHT POSITIONAL   6    F    (A):    295 ;   .09 ;   .05
REMARK   3   TIGHT POSITIONAL   6    G    (A):    295 ;   .15 ;   .05
REMARK   3   TIGHT POSITIONAL   6    H    (A):    295 ;   .14 ;   .05
REMARK   3   TIGHT POSITIONAL   6    I    (A):    295 ;   .08 ;   .05
REMARK   3   TIGHT POSITIONAL   6    J    (A):    295 ;   .08 ;   .05
REMARK   3   TIGHT POSITIONAL   6    K    (A):    295 ;   .08 ;   .05
REMARK   3   TIGHT POSITIONAL   6    L    (A):    295 ;   .09 ;   .05
REMARK   3   TIGHT THERMAL      6    A (A**2):    295 ;   .39 ;   .50
REMARK   3   TIGHT THERMAL      6    B (A**2):    295 ;   .38 ;   .50
REMARK   3   TIGHT THERMAL      6    C (A**2):    295 ;   .30 ;   .50
REMARK   3   TIGHT THERMAL      6    D (A**2):    295 ;   .30 ;   .50
REMARK   3   TIGHT THERMAL      6    E (A**2):    295 ;   .39 ;   .50
REMARK   3   TIGHT THERMAL      6    F (A**2):    295 ;   .32 ;   .50
REMARK   3   TIGHT THERMAL      6    G (A**2):    295 ;   .26 ;   .50
REMARK   3   TIGHT THERMAL      6    H (A**2):    295 ;   .27 ;   .50
REMARK   3   TIGHT THERMAL      6    I (A**2):    295 ;   .43 ;   .50
REMARK   3   TIGHT THERMAL      6    J (A**2):    295 ;   .51 ;   .50
REMARK   3   TIGHT THERMAL      6    K (A**2):    295 ;   .51 ;   .50
REMARK   3   TIGHT THERMAL      6    L (A**2):    295 ;   .36 ;   .50
REMARK   3
REMARK   3  NCS GROUP NUMBER               :   7
REMARK   3     CHAIN NAMES                    : A B C D E F G H I J K L
REMARK   3     NUMBER OF COMPONENTS NCS GROUP :    1
REMARK   3       COMPONENT C  SSSEQI  TO  C   SSSEQI   CODE
REMARK   3           1     A    311       A     330      1
REMARK   3           1     B    311       B     330      1
REMARK   3           1     C    311       C     330      1
REMARK   3           1     D    311       D     330      1
REMARK   3           1     E    311       E     330      1
REMARK   3           1     F    311       F     330      1
REMARK   3           1     G    311       G     330      1
REMARK   3           1     H    311       H     330      1
REMARK   3           1     I    311       I     330      1
REMARK   3           1     J    311       J     330      1
REMARK   3           1     K    311       K     330      1
REMARK   3           1     L    311       L     330      1
REMARK   3                   GROUP CHAIN        COUNT   RMS     WEIGHT
REMARK   3   TIGHT POSITIONAL   7    A    (A):    136 ;   .23 ;   .05
REMARK   3   TIGHT POSITIONAL   7    B    (A):    136 ;   .06 ;   .05
REMARK   3   TIGHT POSITIONAL   7    C    (A):    136 ;   .06 ;   .05
REMARK   3   TIGHT POSITIONAL   7    D    (A):    136 ;   .06 ;   .05
REMARK   3   TIGHT POSITIONAL   7    E    (A):    136 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL   7    F    (A):    136 ;   .06 ;   .05
REMARK   3   TIGHT POSITIONAL   7    G    (A):    136 ;   .08 ;   .05
REMARK   3   TIGHT POSITIONAL   7    H    (A):    136 ;   .09 ;   .05
REMARK   3   TIGHT POSITIONAL   7    I    (A):    136 ;   .06 ;   .05
REMARK   3   TIGHT POSITIONAL   7    J    (A):    136 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL   7    K    (A):    136 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL   7    L    (A):    136 ;   .06 ;   .05
REMARK   3   TIGHT THERMAL      7    A (A**2):    136 ;   .26 ;   .50
REMARK   3   TIGHT THERMAL      7    B (A**2):    136 ;   .31 ;   .50
REMARK   3   TIGHT THERMAL      7    C (A**2):    136 ;   .26 ;   .50
REMARK   3   TIGHT THERMAL      7    D (A**2):    136 ;   .21 ;   .50
REMARK   3   TIGHT THERMAL      7    E (A**2):    136 ;   .27 ;   .50
REMARK   3   TIGHT THERMAL      7    F (A**2):    136 ;   .20 ;   .50
REMARK   3   TIGHT THERMAL      7    G (A**2):    136 ;   .22 ;   .50
REMARK   3   TIGHT THERMAL      7    H (A**2):    136 ;   .26 ;   .50
REMARK   3   TIGHT THERMAL      7    I (A**2):    136 ;   .31 ;   .50
REMARK   3   TIGHT THERMAL      7    J (A**2):    136 ;   .44 ;   .50
REMARK   3   TIGHT THERMAL      7    K (A**2):    136 ;   .42 ;   .50
REMARK   3   TIGHT THERMAL      7    L (A**2):    136 ;   .24 ;   .50
REMARK   3
REMARK   3  NCS GROUP NUMBER               :   8
REMARK   3     CHAIN NAMES                    : A B C D E F G H I J K L
REMARK   3     NUMBER OF COMPONENTS NCS GROUP :    1
REMARK   3       COMPONENT C  SSSEQI  TO  C   SSSEQI   CODE
REMARK   3           1     A    332       A     345      1
REMARK   3           1     B    332       B     345      1
REMARK   3           1     C    332       C     345      1
REMARK   3           1     D    332       D     345      1
REMARK   3           1     E    332       E     345      1
REMARK   3           1     F    332       F     345      1
REMARK   3           1     G    332       G     345      1
REMARK   3           1     H    332       H     345      1
REMARK   3           1     I    332       I     345      1
REMARK   3           1     J    332       J     345      1
REMARK   3           1     K    332       K     345      1
REMARK   3           1     L    332       L     345      1
REMARK   3                   GROUP CHAIN        COUNT   RMS     WEIGHT
REMARK   3   TIGHT POSITIONAL   8    A    (A):    110 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL   8    B    (A):    110 ;   .06 ;   .05
REMARK   3   TIGHT POSITIONAL   8    C    (A):    110 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL   8    D    (A):    110 ;   .26 ;   .05
REMARK   3   TIGHT POSITIONAL   8    E    (A):    110 ;   .08 ;   .05
REMARK   3   TIGHT POSITIONAL   8    F    (A):    110 ;   .08 ;   .05
REMARK   3   TIGHT POSITIONAL   8    G    (A):    110 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL   8    H    (A):    110 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL   8    I    (A):    110 ;   .06 ;   .05
REMARK   3   TIGHT POSITIONAL   8    J    (A):    110 ;   .06 ;   .05
REMARK   3   TIGHT POSITIONAL   8    K    (A):    110 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL   8    L    (A):    110 ;   .07 ;   .05
REMARK   3   TIGHT THERMAL      8    A (A**2):    110 ;   .29 ;   .50
REMARK   3   TIGHT THERMAL      8    B (A**2):    110 ;   .27 ;   .50
REMARK   3   TIGHT THERMAL      8    C (A**2):    110 ;   .27 ;   .50
REMARK   3   TIGHT THERMAL      8    D (A**2):    110 ;   .27 ;   .50
REMARK   3   TIGHT THERMAL      8    E (A**2):    110 ;   .33 ;   .50
REMARK   3   TIGHT THERMAL      8    F (A**2):    110 ;   .25 ;   .50
REMARK   3   TIGHT THERMAL      8    G (A**2):    110 ;   .26 ;   .50
REMARK   3   TIGHT THERMAL      8    H (A**2):    110 ;   .26 ;   .50
REMARK   3   TIGHT THERMAL      8    I (A**2):    110 ;   .29 ;   .50
REMARK   3   TIGHT THERMAL      8    J (A**2):    110 ;   .41 ;   .50
REMARK   3   TIGHT THERMAL      8    K (A**2):    110 ;   .40 ;   .50
REMARK   3   TIGHT THERMAL      8    L (A**2):    110 ;   .26 ;   .50
REMARK   3
REMARK   3  NCS GROUP NUMBER               :   9
REMARK   3     CHAIN NAMES                    : A B C D E F G H I J K L
REMARK   3     NUMBER OF COMPONENTS NCS GROUP :    1
REMARK   3       COMPONENT C  SSSEQI  TO  C   SSSEQI   CODE
REMARK   3           1     A    347       A     359      1
REMARK   3           1     B    347       B     359      1
REMARK   3           1     C    347       C     359      1
REMARK   3           1     D    347       D     359      1
REMARK   3           1     E    347       E     359      1
REMARK   3           1     F    347       F     359      1
REMARK   3           1     G    347       G     359      1
REMARK   3           1     H    347       H     359      1
REMARK   3           1     I    347       I     359      1
REMARK   3           1     J    347       J     359      1
REMARK   3           1     K    347       K     359      1
REMARK   3           1     L    347       L     359      1
REMARK   3                   GROUP CHAIN        COUNT   RMS     WEIGHT
REMARK   3   TIGHT POSITIONAL   9    A    (A):     97 ;   .09 ;   .05
REMARK   3   TIGHT POSITIONAL   9    B    (A):     97 ;   .06 ;   .05
REMARK   3   TIGHT POSITIONAL   9    C    (A):     97 ;   .08 ;   .05
REMARK   3   TIGHT POSITIONAL   9    D    (A):     97 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL   9    E    (A):     97 ;   .09 ;   .05
REMARK   3   TIGHT POSITIONAL   9    F    (A):     97 ;   .08 ;   .05
REMARK   3   TIGHT POSITIONAL   9    G    (A):     97 ;   .08 ;   .05
REMARK   3   TIGHT POSITIONAL   9    H    (A):     97 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL   9    I    (A):     97 ;   .06 ;   .05
REMARK   3   TIGHT POSITIONAL   9    J    (A):     97 ;   .06 ;   .05
REMARK   3   TIGHT POSITIONAL   9    K    (A):     97 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL   9    L    (A):     97 ;   .08 ;   .05
REMARK   3   TIGHT THERMAL      9    A (A**2):     97 ;   .25 ;   .50
REMARK   3   TIGHT THERMAL      9    B (A**2):     97 ;   .29 ;   .50
REMARK   3   TIGHT THERMAL      9    C (A**2):     97 ;   .25 ;   .50
REMARK   3   TIGHT THERMAL      9    D (A**2):     97 ;   .23 ;   .50
REMARK   3   TIGHT THERMAL      9    E (A**2):     97 ;   .26 ;   .50
REMARK   3   TIGHT THERMAL      9    F (A**2):     97 ;   .20 ;   .50
REMARK   3   TIGHT THERMAL      9    G (A**2):     97 ;   .21 ;   .50
REMARK   3   TIGHT THERMAL      9    H (A**2):     97 ;   .22 ;   .50
REMARK   3   TIGHT THERMAL      9    I (A**2):     97 ;   .24 ;   .50
REMARK   3   TIGHT THERMAL      9    J (A**2):     97 ;   .33 ;   .50
REMARK   3   TIGHT THERMAL      9    K (A**2):     97 ;   .34 ;   .50
REMARK   3   TIGHT THERMAL      9    L (A**2):     97 ;   .22 ;   .50
REMARK   3
REMARK   3  NCS GROUP NUMBER               :  10
REMARK   3     CHAIN NAMES                    : A B C D E F G H I J K L
REMARK   3     NUMBER OF COMPONENTS NCS GROUP :    1
REMARK   3       COMPONENT C  SSSEQI  TO  C   SSSEQI   CODE
REMARK   3           1     A    361       A     382      1
REMARK   3           1     B    361       B     382      1
REMARK   3           1     C    361       C     382      1
REMARK   3           1     D    361       D     382      1
REMARK   3           1     E    361       E     382      1
REMARK   3           1     F    361       F     382      1
REMARK   3           1     G    361       G     382      1
REMARK   3           1     H    361       H     382      1
REMARK   3           1     I    361       I     382      1
REMARK   3           1     J    361       J     382      1
REMARK   3           1     K    361       K     382      1
REMARK   3           1     L    361       L     382      1
REMARK   3                   GROUP CHAIN        COUNT   RMS     WEIGHT
REMARK   3   TIGHT POSITIONAL  10    A    (A):    163 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL  10    B    (A):    163 ;   .23 ;   .05
REMARK   3   TIGHT POSITIONAL  10    C    (A):    163 ;   .21 ;   .05
REMARK   3   TIGHT POSITIONAL  10    D    (A):    163 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL  10    E    (A):    163 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL  10    F    (A):    163 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL  10    G    (A):    163 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL  10    H    (A):    163 ;   .07 ;   .05
REMARK   3   TIGHT POSITIONAL  10    I    (A):    163 ;   .08 ;   .05
REMARK   3   TIGHT POSITIONAL  10    J    (A):    163 ;   .08 ;   .05
REMARK   3   TIGHT POSITIONAL  10    K    (A):    163 ;   .09 ;   .05
REMARK   3   TIGHT POSITIONAL  10    L    (A):    163 ;   .07 ;   .05
REMARK   3   TIGHT THERMAL     10    A (A**2):    163 ;   .22 ;   .50
REMARK   3   TIGHT THERMAL     10    B (A**2):    163 ;   .37 ;   .50
REMARK   3   TIGHT THERMAL     10    C (A**2):    163 ;   .27 ;   .50
REMARK   3   TIGHT THERMAL     10    D (A**2):    163 ;   .24 ;   .50
REMARK   3   TIGHT THERMAL     10    E (A**2):    163 ;   .22 ;   .50
REMARK   3   TIGHT THERMAL     10    F (A**2):    163 ;   .24 ;   .50
REMARK   3   TIGHT THERMAL     10    G (A**2):    163 ;   .23 ;   .50
REMARK   3   TIGHT THERMAL     10    H (A**2):    163 ;   .24 ;   .50
REMARK   3   TIGHT THERMAL     10    I (A**2):    163 ;   .35 ;   .50
REMARK   3   TIGHT THERMAL     10    J (A**2):    163 ;   .45 ;   .50
REMARK   3   TIGHT THERMAL     10    K (A**2):    163 ;   .49 ;   .50
REMARK   3   TIGHT THERMAL     10    L (A**2):    163 ;   .21 ;   .50
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.40
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE
REMARK   3   RIDING POSITIONS. RESIDUES 242-267 ARE DISORDERED.
REMARK   3   ACETYL MOIETY WAS LEFT UNMODELLED.
REMARK   3   RESIDUAL DENSITY NEAR SER149, POSSIBLY INDICATING MULTIPLE
REMARK   3   REACTION STATES WITH PARTIAL OCCUPANCIES, WAS LEFT
REMARK   3   UNMODELLED.
REMARK   4
REMARK   4 2VAT COMPLIES WITH FORMAT V. 3.1, 01-AUG-2007
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY EBI  ON  4-SEP-2007.
REMARK 100 THE EBI ID CODE IS EBI-33680.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 22-APR-2004
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : NULL
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y ; Y
REMARK 200  RADIATION SOURCE               : ESRF ; MAX II
REMARK 200  BEAMLINE                       : ID14-1 ; I911-3
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M ; M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.934 ; 0.978
REMARK 200  MONOCHROMATOR                  : DIAMOND (111), GE(220)
REMARK 200  OPTICS                         : TOROIDAL MIRROR
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : MOSFLM
REMARK 200  DATA SCALING SOFTWARE          : SCALA
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 258318
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.20
REMARK 200  RESOLUTION RANGE LOW       (A) : 60.97
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 6.0
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.6
REMARK 200  DATA REDUNDANCY                : 3.1
REMARK 200  R MERGE                    (I) : 0.09
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 10.60
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.20
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.32
REMARK 200  COMPLETENESS FOR SHELL     (%) : 95.8
REMARK 200  DATA REDUNDANCY IN SHELL       : 2.9
REMARK 200  R MERGE FOR SHELL          (I) : 0.25
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 3.70
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: SAD
REMARK 200 SOFTWARE USED: SHELX, AUTOSHARP
REMARK 200 STARTING MODEL: NONE
REMARK 200
REMARK 200 REMARK: NONE
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 52
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.56
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 18-19% PEG 4000, 0.1M IMIDAZOLE,
REMARK 280   0.5M NACL, 0.2M SODIUM ACETATE
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       54.63900
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 295
REMARK 295 NON-CRYSTALLOGRAPHIC SYMMETRY
REMARK 295 THE TRANSFORMATIONS PRESENTED ON THE MTRIX RECORDS BELOW
REMARK 295 DESCRIBE NON-CRYSTALLOGRAPHIC RELATIONSHIPS AMONG ATOMS
REMARK 295 IN THIS ENTRY.  APPLYING THE APPROPRIATE MTRIX
REMARK 295 TRANSFORMATION TO THE RESIDUES LISTED FIRST WILL YIELD
REMARK 295 APPROXIMATE COORDINATES FOR THE RESIDUES LISTED SECOND.
REMARK 295 CHAIN IDENTIFIERS GIVEN AS "?" REFER TO CHAINS FOR WHICH
REMARK 295 ATOMS ARE NOT FOUND IN THIS ENTRY.
REMARK 295
REMARK 295               APPLIED TO          TRANSFORMED TO
REMARK 295   TRANSFORM CHAIN  RESIDUES       CHAIN  RESIDUES     RMSD
REMARK 295    M  1       B    7 .. 382         A    7 .. 382     0.362
REMARK 295    M  2       C    7 .. 382         A    7 .. 382     0.517
REMARK 295    M  3       D    7 .. 382         A    7 .. 382     0.520
REMARK 295    M  4       E    7 .. 382         A    7 .. 382     0.195
REMARK 295    M  5       F    7 .. 382         A    7 .. 382     0.515
REMARK 295    M  6       G    7 .. 382         A    7 .. 382     0.584
REMARK 295    M  7       H    7 .. 382         A    7 .. 382     0.520
REMARK 295    M  8       I    7 .. 382         A    7 .. 382     0.351
REMARK 295    M  9       J    7 .. 382         A    7 .. 382     0.408
REMARK 295    M 10       K    7 .. 382         A    7 .. 382     0.392
REMARK 295    M 11       L    7 .. 382         A    7 .. 382     0.500
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3, 4, 5, 6
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY.  THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 GENERATING THE BIOMOLECULE
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 4900 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 31460 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -38.9 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, I
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 4950 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 31280 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -30.1 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, E
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350 BIOMOLECULE: 3
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 4260 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 31170 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -24.4 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D, K
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350 BIOMOLECULE: 4
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 3460 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 30580 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -30.2 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: F, H
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350 BIOMOLECULE: 5
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 4300 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 30380 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -24.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: G, L
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350 BIOMOLECULE: 6
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 4220 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 31320 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -23.5 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, J
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A   -58
REMARK 465     LEU A   -57
REMARK 465     PRO A   -56
REMARK 465     SER A   -55
REMARK 465     ALA A   -54
REMARK 465     GLN A   -53
REMARK 465     VAL A   -52
REMARK 465     ALA A   -51
REMARK 465     ARG A   -50
REMARK 465     LEU A   -49
REMARK 465     LYS A   -48
REMARK 465     PRO A   -47
REMARK 465     ASP A   -46
REMARK 465     PRO A   -45
REMARK 465     PHE A   -44
REMARK 465     PRO A   -43
REMARK 465     PRO A   -42
REMARK 465     SER A   -41
REMARK 465     LEU A   -40
REMARK 465     SER A   -39
REMARK 465     PRO A   -38
REMARK 465     ILE A   -37
REMARK 465     PRO A   -36
REMARK 465     HIS A   -35
REMARK 465     GLY A   -34
REMARK 465     ALA A   -33
REMARK 465     VAL A   -32
REMARK 465     THR A   -31
REMARK 465     PHE A   -30
REMARK 465     ALA A   -29
REMARK 465     ALA A   -28
REMARK 465     LEU A   -27
REMARK 465     ALA A   -26
REMARK 465     PRO A   -25
REMARK 465     CYS A   -24
REMARK 465     HIS A   -23
REMARK 465     ASN A   -22
REMARK 465     LEU A   -21
REMARK 465     PRO A   -20
REMARK 465     ILE A   -19
REMARK 465     PHE A   -18
REMARK 465     SER A   -17
REMARK 465     SER A   -16
REMARK 465     ARG A   -15
REMARK 465     GLN A   -14
REMARK 465     MET A   -13
REMARK 465     LEU A   -12
REMARK 465     ARG A   -11
REMARK 465     ASP A   -10
REMARK 465     SER A    -9
REMARK 465     LEU A    -8
REMARK 465     THR A    -7
REMARK 465     TYR A    -6
REMARK 465     SER A    -5
REMARK 465     HIS A    -4
REMARK 465     THR A    -3
REMARK 465     SER A    -2
REMARK 465     PRO A    -1
REMARK 465     THR A     0
REMARK 465     MET A     1
REMARK 465     SER A     2
REMARK 465     PRO A     3
REMARK 465     GLN A     4
REMARK 465     ILE A     5
REMARK 465     ALA A     6
REMARK 465     GLY A   110
REMARK 465     GLN A   111
REMARK 465     GLN A   242
REMARK 465     ALA A   243
REMARK 465     GLY A   244
REMARK 465     ARG A   245
REMARK 465     ASN A   246
REMARK 465     ILE A   247
REMARK 465     SER A   248
REMARK 465     SER A   249
REMARK 465     GLN A   250
REMARK 465     ASP A   251
REMARK 465     ALA A   252
REMARK 465     LYS A   253
REMARK 465     LYS A   254
REMARK 465     GLU A   255
REMARK 465     ILE A   256
REMARK 465     ASN A   257
REMARK 465     GLY A   258
REMARK 465     THR A   259
REMARK 465     ASP A   260
REMARK 465     SER A   261
REMARK 465     GLY A   262
REMARK 465     ASN A   263
REMARK 465     SER A   264
REMARK 465     HIS A   265
REMARK 465     ARG A   266
REMARK 465     ALA A   267
REMARK 465     GLY A   268
REMARK 465     SER A   383
REMARK 465     LEU A   384
REMARK 465     MET A   385
REMARK 465     MET B   -58
REMARK 465     LEU B   -57
REMARK 465     PRO B   -56
REMARK 465     SER B   -55
REMARK 465     ALA B   -54
REMARK 465     GLN B   -53
REMARK 465     VAL B   -52
REMARK 465     ALA B   -51
REMARK 465     ARG B   -50
REMARK 465     LEU B   -49
REMARK 465     LYS B   -48
REMARK 465     PRO B   -47
REMARK 465     ASP B   -46
REMARK 465     PRO B   -45
REMARK 465     PHE B   -44
REMARK 465     PRO B   -43
REMARK 465     PRO B   -42
REMARK 465     SER B   -41
REMARK 465     LEU B   -40
REMARK 465     SER B   -39
REMARK 465     PRO B   -38
REMARK 465     ILE B   -37
REMARK 465     PRO B   -36
REMARK 465     HIS B   -35
REMARK 465     GLY B   -34
REMARK 465     ALA B   -33
REMARK 465     VAL B   -32
REMARK 465     THR B   -31
REMARK 465     PHE B   -30
REMARK 465     ALA B   -29
REMARK 465     ALA B   -28
REMARK 465     LEU B   -27
REMARK 465     ALA B   -26
REMARK 465     PRO B   -25
REMARK 465     CYS B   -24
REMARK 465     HIS B   -23
REMARK 465     ASN B   -22
REMARK 465     LEU B   -21
REMARK 465     PRO B   -20
REMARK 465     ILE B   -19
REMARK 465     PHE B   -18
REMARK 465     SER B   -17
REMARK 465     SER B   -16
REMARK 465     ARG B   -15
REMARK 465     GLN B   -14
REMARK 465     MET B   -13
REMARK 465     LEU B   -12
REMARK 465     ARG B   -11
REMARK 465     ASP B   -10
REMARK 465     SER B    -9
REMARK 465     LEU B    -8
REMARK 465     THR B    -7
REMARK 465     TYR B    -6
REMARK 465     SER B    -5
REMARK 465     HIS B    -4
REMARK 465     THR B    -3
REMARK 465     SER B    -2
REMARK 465     PRO B    -1
REMARK 465     THR B     0
REMARK 465     MET B     1
REMARK 465     SER B     2
REMARK 465     PRO B     3
REMARK 465     GLN B     4
REMARK 465     ILE B     5
REMARK 465     ALA B     6
REMARK 465     GLU B   109
REMARK 465     GLY B   110
REMARK 465     GLN B   111
REMARK 465     GLN B   242
REMARK 465     ALA B   243
REMARK 465     GLY B   244
REMARK 465     ARG B   245
REMARK 465     ASN B   246
REMARK 465     ILE B   247
REMARK 465     SER B   248
REMARK 465     SER B   249
REMARK 465     GLN B   250
REMARK 465     ASP B   251
REMARK 465     ALA B   252
REMARK 465     LYS B   253
REMARK 465     LYS B   254
REMARK 465     GLU B   255
REMARK 465     ILE B   256
REMARK 465     ASN B   257
REMARK 465     GLY B   258
REMARK 465     THR B   259
REMARK 465     ASP B   260
REMARK 465     SER B   261
REMARK 465     GLY B   262
REMARK 465     ASN B   263
REMARK 465     SER B   264
REMARK 465     HIS B   265
REMARK 465     ARG B   266
REMARK 465     ALA B   267
REMARK 465     SER B   383
REMARK 465     LEU B   384
REMARK 465     MET B   385
REMARK 465     MET C   -58
REMARK 465     LEU C   -57
REMARK 465     PRO C   -56
REMARK 465     SER C   -55
REMARK 465     ALA C   -54
REMARK 465     GLN C   -53
REMARK 465     VAL C   -52
REMARK 465     ALA C   -51
REMARK 465     ARG C   -50
REMARK 465     LEU C   -49
REMARK 465     LYS C   -48
REMARK 465     PRO C   -47
REMARK 465     ASP C   -46
REMARK 465     PRO C   -45
REMARK 465     PHE C   -44
REMARK 465     PRO C   -43
REMARK 465     PRO C   -42
REMARK 465     SER C   -41
REMARK 465     LEU C   -40
REMARK 465     SER C   -39
REMARK 465     PRO C   -38
REMARK 465     ILE C   -37
REMARK 465     PRO C   -36
REMARK 465     HIS C   -35
REMARK 465     GLY C   -34
REMARK 465     ALA C   -33
REMARK 465     VAL C   -32
REMARK 465     THR C   -31
REMARK 465     PHE C   -30
REMARK 465     ALA C   -29
REMARK 465     ALA C   -28
REMARK 465     LEU C   -27
REMARK 465     ALA C   -26
REMARK 465     PRO C   -25
REMARK 465     CYS C   -24
REMARK 465     HIS C   -23
REMARK 465     ASN C   -22
REMARK 465     LEU C   -21
REMARK 465     PRO C   -20
REMARK 465     ILE C   -19
REMARK 465     PHE C   -18
REMARK 465     SER C   -17
REMARK 465     SER C   -16
REMARK 465     ARG C   -15
REMARK 465     GLN C   -14
REMARK 465     MET C   -13
REMARK 465     LEU C   -12
REMARK 465     ARG C   -11
REMARK 465     ASP C   -10
REMARK 465     SER C    -9
REMARK 465     LEU C    -8
REMARK 465     THR C    -7
REMARK 465     TYR C    -6
REMARK 465     SER C    -5
REMARK 465     HIS C    -4
REMARK 465     THR C    -3
REMARK 465     SER C    -2
REMARK 465     PRO C    -1
REMARK 465     THR C     0
REMARK 465     MET C     1
REMARK 465     SER C     2
REMARK 465     PRO C     3
REMARK 465     GLN C     4
REMARK 465     ILE C     5
REMARK 465     ALA C     6
REMARK 465     ALA C   238
REMARK 465     PRO C   239
REMARK 465     GLY C   240
REMARK 465     VAL C   241
REMARK 465     GLN C   242
REMARK 465     ALA C   243
REMARK 465     GLY C   244
REMARK 465     ARG C   245
REMARK 465     ASN C   246
REMARK 465     ILE C   247
REMARK 465     SER C   248
REMARK 465     SER C   249
REMARK 465     GLN C   250
REMARK 465     ASP C   251
REMARK 465     ALA C   252
REMARK 465     LYS C   253
REMARK 465     LYS C   254
REMARK 465     GLU C   255
REMARK 465     ILE C   256
REMARK 465     ASN C   257
REMARK 465     GLY C   258
REMARK 465     THR C   259
REMARK 465     ASP C   260
REMARK 465     SER C   261
REMARK 465     GLY C   262
REMARK 465     ASN C   263
REMARK 465     SER C   264
REMARK 465     HIS C   265
REMARK 465     ARG C   266
REMARK 465     ALA C   267
REMARK 465     GLY C   268
REMARK 465     SER C   383
REMARK 465     LEU C   384
REMARK 465     MET C   385
REMARK 465     MET D   -58
REMARK 465     LEU D   -57
REMARK 465     PRO D   -56
REMARK 465     SER D   -55
REMARK 465     ALA D   -54
REMARK 465     GLN D   -53
REMARK 465     VAL D   -52
REMARK 465     ALA D   -51
REMARK 465     ARG D   -50
REMARK 465     LEU D   -49
REMARK 465     LYS D   -48
REMARK 465     PRO D   -47
REMARK 465     ASP D   -46
REMARK 465     PRO D   -45
REMARK 465     PHE D   -44
REMARK 465     PRO D   -43
REMARK 465     PRO D   -42
REMARK 465     SER D   -41
REMARK 465     LEU D   -40
REMARK 465     SER D   -39
REMARK 465     PRO D   -38
REMARK 465     ILE D   -37
REMARK 465     PRO D   -36
REMARK 465     HIS D   -35
REMARK 465     GLY D   -34
REMARK 465     ALA D   -33
REMARK 465     VAL D   -32
REMARK 465     THR D   -31
REMARK 465     PHE D   -30
REMARK 465     ALA D   -29
REMARK 465     ALA D   -28
REMARK 465     LEU D   -27
REMARK 465     ALA D   -26
REMARK 465     PRO D   -25
REMARK 465     CYS D   -24
REMARK 465     HIS D   -23
REMARK 465     ASN D   -22
REMARK 465     LEU D   -21
REMARK 465     PRO D   -20
REMARK 465     ILE D   -19
REMARK 465     PHE D   -18
REMARK 465     SER D   -17
REMARK 465     SER D   -16
REMARK 465     ARG D   -15
REMARK 465     GLN D   -14
REMARK 465     MET D   -13
REMARK 465     LEU D   -12
REMARK 465     ARG D   -11
REMARK 465     ASP D   -10
REMARK 465     SER D    -9
REMARK 465     LEU D    -8
REMARK 465     THR D    -7
REMARK 465     TYR D    -6
REMARK 465     SER D    -5
REMARK 465     HIS D    -4
REMARK 465     THR D    -3
REMARK 465     SER D    -2
REMARK 465     PRO D    -1
REMARK 465     THR D     0
REMARK 465     MET D     1
REMARK 465     SER D     2
REMARK 465     PRO D     3
REMARK 465     GLN D     4
REMARK 465     ILE D     5
REMARK 465     ALA D     6
REMARK 465     ALA D   238
REMARK 465     PRO D   239
REMARK 465     GLY D   240
REMARK 465     VAL D   241
REMARK 465     GLN D   242
REMARK 465     ALA D   243
REMARK 465     GLY D   244
REMARK 465     ARG D   245
REMARK 465     ASN D   246
REMARK 465     ILE D   247
REMARK 465     SER D   248
REMARK 465     SER D   249
REMARK 465     GLN D   250
REMARK 465     ASP D   251
REMARK 465     ALA D   252
REMARK 465     LYS D   253
REMARK 465     LYS D   254
REMARK 465     GLU D   255
REMARK 465     ILE D   256
REMARK 465     ASN D   257
REMARK 465     GLY D   258
REMARK 465     THR D   259
REMARK 465     ASP D   260
REMARK 465     SER D   261
REMARK 465     GLY D   262
REMARK 465     ASN D   263
REMARK 465     SER D   264
REMARK 465     HIS D   265
REMARK 465     ARG D   266
REMARK 465     ALA D   267
REMARK 465     GLY D   268
REMARK 465     SER D   383
REMARK 465     LEU D   384
REMARK 465     MET D   385
REMARK 465     MET E   -58
REMARK 465     LEU E   -57
REMARK 465     PRO E   -56
REMARK 465     SER E   -55
REMARK 465     ALA E   -54
REMARK 465     GLN E   -53
REMARK 465     VAL E   -52
REMARK 465     ALA E   -51
REMARK 465     ARG E   -50
REMARK 465     LEU E   -49
REMARK 465     LYS E   -48
REMARK 465     PRO E   -47
REMARK 465     ASP E   -46
REMARK 465     PRO E   -45
REMARK 465     PHE E   -44
REMARK 465     PRO E   -43
REMARK 465     PRO E   -42
REMARK 465     SER E   -41
REMARK 465     LEU E   -40
REMARK 465     SER E   -39
REMARK 465     PRO E   -38
REMARK 465     ILE E   -37
REMARK 465     PRO E   -36
REMARK 465     HIS E   -35
REMARK 465     GLY E   -34
REMARK 465     ALA E   -33
REMARK 465     VAL E   -32
REMARK 465     THR E   -31
REMARK 465     PHE E   -30
REMARK 465     ALA E   -29
REMARK 465     ALA E   -28
REMARK 465     LEU E   -27
REMARK 465     ALA E   -26
REMARK 465     PRO E   -25
REMARK 465     CYS E   -24
REMARK 465     HIS E   -23
REMARK 465     ASN E   -22
REMARK 465     LEU E   -21
REMARK 465     PRO E   -20
REMARK 465     ILE E   -19
REMARK 465     PHE E   -18
REMARK 465     SER E   -17
REMARK 465     SER E   -16
REMARK 465     ARG E   -15
REMARK 465     GLN E   -14
REMARK 465     MET E   -13
REMARK 465     LEU E   -12
REMARK 465     ARG E   -11
REMARK 465     ASP E   -10
REMARK 465     SER E    -9
REMARK 465     LEU E    -8
REMARK 465     THR E    -7
REMARK 465     TYR E    -6
REMARK 465     SER E    -5
REMARK 465     HIS E    -4
REMARK 465     THR E    -3
REMARK 465     SER E    -2
REMARK 465     PRO E    -1
REMARK 465     THR E     0
REMARK 465     MET E     1
REMARK 465     SER E     2
REMARK 465     PRO E     3
REMARK 465     GLN E     4
REMARK 465     ILE E     5
REMARK 465     ALA E     6
REMARK 465     GLU E   109
REMARK 465     GLY E   110
REMARK 465     GLN E   111
REMARK 465     ARG E   112
REMARK 465     GLN E   242
REMARK 465     ALA E   243
REMARK 465     GLY E   244
REMARK 465     ARG E   245
REMARK 465     ASN E   246
REMARK 465     ILE E   247
REMARK 465     SER E   248
REMARK 465     SER E   249
REMARK 465     GLN E   250
REMARK 465     ASP E   251
REMARK 465     ALA E   252
REMARK 465     LYS E   253
REMARK 465     LYS E   254
REMARK 465     GLU E   255
REMARK 465     ILE E   256
REMARK 465     ASN E   257
REMARK 465     GLY E   258
REMARK 465     THR E   259
REMARK 465     ASP E   260
REMARK 465     SER E   261
REMARK 465     GLY E   262
REMARK 465     ASN E   263
REMARK 465     SER E   264
REMARK 465     HIS E   265
REMARK 465     ARG E   266
REMARK 465     ALA E   267
REMARK 465     SER E   383
REMARK 465     LEU E   384
REMARK 465     MET E   385
REMARK 465     MET F   -58
REMARK 465     LEU F   -57
REMARK 465     PRO F   -56
REMARK 465     SER F   -55
REMARK 465     ALA F   -54
REMARK 465     GLN F   -53
REMARK 465     VAL F   -52
REMARK 465     ALA F   -51
REMARK 465     ARG F   -50
REMARK 465     LEU F   -49
REMARK 465     LYS F   -48
REMARK 465     PRO F   -47
REMARK 465     ASP F   -46
REMARK 465     PRO F   -45
REMARK 465     PHE F   -44
REMARK 465     PRO F   -43
REMARK 465     PRO F   -42
REMARK 465     SER F   -41
REMARK 465     LEU F   -40
REMARK 465     SER F   -39
REMARK 465     PRO F   -38
REMARK 465     ILE F   -37
REMARK 465     PRO F   -36
REMARK 465     HIS F   -35
REMARK 465     GLY F   -34
REMARK 465     ALA F   -33
REMARK 465     VAL F   -32
REMARK 465     THR F   -31
REMARK 465     PHE F   -30
REMARK 465     ALA F   -29
REMARK 465     ALA F   -28
REMARK 465     LEU F   -27
REMARK 465     ALA F   -26
REMARK 465     PRO F   -25
REMARK 465     CYS F   -24
REMARK 465     HIS F   -23
REMARK 465     ASN F   -22
REMARK 465     LEU F   -21
REMARK 465     PRO F   -20
REMARK 465     ILE F   -19
REMARK 465     PHE F   -18
REMARK 465     SER F   -17
REMARK 465     SER F   -16
REMARK 465     ARG F   -15
REMARK 465     GLN F   -14
REMARK 465     MET F   -13
REMARK 465     LEU F   -12
REMARK 465     ARG F   -11
REMARK 465     ASP F   -10
REMARK 465     SER F    -9
REMARK 465     LEU F    -8
REMARK 465     THR F    -7
REMARK 465     TYR F    -6
REMARK 465     SER F    -5
REMARK 465     HIS F    -4
REMARK 465     THR F    -3
REMARK 465     SER F    -2
REMARK 465     PRO F    -1
REMARK 465     THR F     0
REMARK 465     MET F     1
REMARK 465     SER F     2
REMARK 465     PRO F     3
REMARK 465     GLN F     4
REMARK 465     ILE F     5
REMARK 465     ALA F     6
REMARK 465     GLU F   109
REMARK 465     GLY F   110
REMARK 465     GLN F   111
REMARK 465     ARG F   112
REMARK 465     ALA F   238
REMARK 465     PRO F   239
REMARK 465     GLY F   240
REMARK 465     VAL F   241
REMARK 465     GLN F   242
REMARK 465     ALA F   243
REMARK 465     GLY F   244
REMARK 465     ARG F   245
REMARK 465     ASN F   246
REMARK 465     ILE F   247
REMARK 465     SER F   248
REMARK 465     SER F   249
REMARK 465     GLN F   250
REMARK 465     ASP F   251
REMARK 465     ALA F   252
REMARK 465     LYS F   253
REMARK 465     LYS F   254
REMARK 465     GLU F   255
REMARK 465     ILE F   256
REMARK 465     ASN F   257
REMARK 465     GLY F   258
REMARK 465     THR F   259
REMARK 465     ASP F   260
REMARK 465     SER F   261
REMARK 465     GLY F   262
REMARK 465     ASN F   263
REMARK 465     SER F   264
REMARK 465     HIS F   265
REMARK 465     ARG F   266
REMARK 465     ALA F   267
REMARK 465     SER F   383
REMARK 465     LEU F   384
REMARK 465     MET F   385
REMARK 465     MET G   -58
REMARK 465     LEU G   -57
REMARK 465     PRO G   -56
REMARK 465     SER G   -55
REMARK 465     ALA G   -54
REMARK 465     GLN G   -53
REMARK 465     VAL G   -52
REMARK 465     ALA G   -51
REMARK 465     ARG G   -50
REMARK 465     LEU G   -49
REMARK 465     LYS G   -48
REMARK 465     PRO G   -47
REMARK 465     ASP G   -46
REMARK 465     PRO G   -45
REMARK 465     PHE G   -44
REMARK 465     PRO G   -43
REMARK 465     PRO G   -42
REMARK 465     SER G   -41
REMARK 465     LEU G   -40
REMARK 465     SER G   -39
REMARK 465     PRO G   -38
REMARK 465     ILE G   -37
REMARK 465     PRO G   -36
REMARK 465     HIS G   -35
REMARK 465     GLY G   -34
REMARK 465     ALA G   -33
REMARK 465     VAL G   -32
REMARK 465     THR G   -31
REMARK 465     PHE G   -30
REMARK 465     ALA G   -29
REMARK 465     ALA G   -28
REMARK 465     LEU G   -27
REMARK 465     ALA G   -26
REMARK 465     PRO G   -25
REMARK 465     CYS G   -24
REMARK 465     HIS G   -23
REMARK 465     ASN G   -22
REMARK 465     LEU G   -21
REMARK 465     PRO G   -20
REMARK 465     ILE G   -19
REMARK 465     PHE G   -18
REMARK 465     SER G   -17
REMARK 465     SER G   -16
REMARK 465     ARG G   -15
REMARK 465     GLN G   -14
REMARK 465     MET G   -13
REMARK 465     LEU G   -12
REMARK 465     ARG G   -11
REMARK 465     ASP G   -10
REMARK 465     SER G    -9
REMARK 465     LEU G    -8
REMARK 465     THR G    -7
REMARK 465     TYR G    -6
REMARK 465     SER G    -5
REMARK 465     HIS G    -4
REMARK 465     THR G    -3
REMARK 465     SER G    -2
REMARK 465     PRO G    -1
REMARK 465     THR G     0
REMARK 465     MET G     1
REMARK 465     SER G     2
REMARK 465     PRO G     3
REMARK 465     GLN G     4
REMARK 465     ILE G     5
REMARK 465     ALA G     6
REMARK 465     GLU G   109
REMARK 465     GLY G   110
REMARK 465     GLN G   111
REMARK 465     ALA G   238
REMARK 465     PRO G   239
REMARK 465     GLY G   240
REMARK 465     VAL G   241
REMARK 465     GLN G   242
REMARK 465     ALA G   243
REMARK 465     GLY G   244
REMARK 465     ARG G   245
REMARK 465     ASN G   246
REMARK 465     ILE G   247
REMARK 465     SER G   248
REMARK 465     SER G   249
REMARK 465     GLN G   250
REMARK 465     ASP G   251
REMARK 465     ALA G   252
REMARK 465     LYS G   253
REMARK 465     LYS G   254
REMARK 465     GLU G   255
REMARK 465     ILE G   256
REMARK 465     ASN G   257
REMARK 465     GLY G   258
REMARK 465     THR G   259
REMARK 465     ASP G   260
REMARK 465     SER G   261
REMARK 465     GLY G   262
REMARK 465     ASN G   263
REMARK 465     SER G   264
REMARK 465     HIS G   265
REMARK 465     ARG G   266
REMARK 465     ALA G   267
REMARK 465     GLY G   268
REMARK 465     SER G   383
REMARK 465     LEU G   384
REMARK 465     MET G   385
REMARK 465     MET H   -58
REMARK 465     LEU H   -57
REMARK 465     PRO H   -56
REMARK 465     SER H   -55
REMARK 465     ALA H   -54
REMARK 465     GLN H   -53
REMARK 465     VAL H   -52
REMARK 465     ALA H   -51
REMARK 465     ARG H   -50
REMARK 465     LEU H   -49
REMARK 465     LYS H   -48
REMARK 465     PRO H   -47
REMARK 465     ASP H   -46
REMARK 465     PRO H   -45
REMARK 465     PHE H   -44
REMARK 465     PRO H   -43
REMARK 465     PRO H   -42
REMARK 465     SER H   -41
REMARK 465     LEU H   -40
REMARK 465     SER H   -39
REMARK 465     PRO H   -38
REMARK 465     ILE H   -37
REMARK 465     PRO H   -36
REMARK 465     HIS H   -35
REMARK 465     GLY H   -34
REMARK 465     ALA H   -33
REMARK 465     VAL H   -32
REMARK 465     THR H   -31
REMARK 465     PHE H   -30
REMARK 465     ALA H   -29
REMARK 465     ALA H   -28
REMARK 465     LEU H   -27
REMARK 465     ALA H   -26
REMARK 465     PRO H   -25
REMARK 465     CYS H   -24
REMARK 465     HIS H   -23
REMARK 465     ASN H   -22
REMARK 465     LEU H   -21
REMARK 465     PRO H   -20
REMARK 465     ILE H   -19
REMARK 465     PHE H   -18
REMARK 465     SER H   -17
REMARK 465     SER H   -16
REMARK 465     ARG H   -15
REMARK 465     GLN H   -14
REMARK 465     MET H   -13
REMARK 465     LEU H   -12
REMARK 465     ARG H   -11
REMARK 465     ASP H   -10
REMARK 465     SER H    -9
REMARK 465     LEU H    -8
REMARK 465     THR H    -7
REMARK 465     TYR H    -6
REMARK 465     SER H    -5
REMARK 465     HIS H    -4
REMARK 465     THR H    -3
REMARK 465     SER H    -2
REMARK 465     PRO H    -1
REMARK 465     THR H     0
REMARK 465     MET H     1
REMARK 465     SER H     2
REMARK 465     PRO H     3
REMARK 465     GLN H     4
REMARK 465     ILE H     5
REMARK 465     ALA H     6
REMARK 465     GLU H   109
REMARK 465     GLY H   110
REMARK 465     GLN H   111
REMARK 465     VAL H   241
REMARK 465     GLN H   242
REMARK 465     ALA H   243
REMARK 465     GLY H   244
REMARK 465     ARG H   245
REMARK 465     ASN H   246
REMARK 465     ILE H   247
REMARK 465     SER H   248
REMARK 465     SER H   249
REMARK 465     GLN H   250
REMARK 465     ASP H   251
REMARK 465     ALA H   252
REMARK 465     LYS H   253
REMARK 465     LYS H   254
REMARK 465     GLU H   255
REMARK 465     ILE H   256
REMARK 465     ASN H   257
REMARK 465     GLY H   258
REMARK 465     THR H   259
REMARK 465     ASP H   260
REMARK 465     SER H   261
REMARK 465     GLY H   262
REMARK 465     ASN H   263
REMARK 465     SER H   264
REMARK 465     HIS H   265
REMARK 465     ARG H   266
REMARK 465     ALA H   267
REMARK 465     GLY H   268
REMARK 465     SER H   383
REMARK 465     LEU H   384
REMARK 465     MET H   385
REMARK 465     MET I   -58
REMARK 465     LEU I   -57
REMARK 465     PRO I   -56
REMARK 465     SER I   -55
REMARK 465     ALA I   -54
REMARK 465     GLN I   -53
REMARK 465     VAL I   -52
REMARK 465     ALA I   -51
REMARK 465     ARG I   -50
REMARK 465     LEU I   -49
REMARK 465     LYS I   -48
REMARK 465     PRO I   -47
REMARK 465     ASP I   -46
REMARK 465     PRO I   -45
REMARK 465     PHE I   -44
REMARK 465     PRO I   -43
REMARK 465     PRO I   -42
REMARK 465     SER I   -41
REMARK 465     LEU I   -40
REMARK 465     SER I   -39
REMARK 465     PRO I   -38
REMARK 465     ILE I   -37
REMARK 465     PRO I   -36
REMARK 465     HIS I   -35
REMARK 465     GLY I   -34
REMARK 465     ALA I   -33
REMARK 465     VAL I   -32
REMARK 465     THR I   -31
REMARK 465     PHE I   -30
REMARK 465     ALA I   -29
REMARK 465     ALA I   -28
REMARK 465     LEU I   -27
REMARK 465     ALA I   -26
REMARK 465     PRO I   -25
REMARK 465     CYS I   -24
REMARK 465     HIS I   -23
REMARK 465     ASN I   -22
REMARK 465     LEU I   -21
REMARK 465     PRO I   -20
REMARK 465     ILE I   -19
REMARK 465     PHE I   -18
REMARK 465     SER I   -17
REMARK 465     SER I   -16
REMARK 465     ARG I   -15
REMARK 465     GLN I   -14
REMARK 465     MET I   -13
REMARK 465     LEU I   -12
REMARK 465     ARG I   -11
REMARK 465     ASP I   -10
REMARK 465     SER I    -9
REMARK 465     LEU I    -8
REMARK 465     THR I    -7
REMARK 465     TYR I    -6
REMARK 465     SER I    -5
REMARK 465     HIS I    -4
REMARK 465     THR I    -3
REMARK 465     SER I    -2
REMARK 465     PRO I    -1
REMARK 465     THR I     0
REMARK 465     MET I     1
REMARK 465     SER I     2
REMARK 465     PRO I     3
REMARK 465     GLN I     4
REMARK 465     ILE I     5
REMARK 465     ALA I     6
REMARK 465     GLU I   109
REMARK 465     GLY I   110
REMARK 465     GLN I   111
REMARK 465     GLN I   242
REMARK 465     ALA I   243
REMARK 465     GLY I   244
REMARK 465     ARG I   245
REMARK 465     ASN I   246
REMARK 465     ILE I   247
REMARK 465     SER I   248
REMARK 465     SER I   249
REMARK 465     GLN I   250
REMARK 465     ASP I   251
REMARK 465     ALA I   252
REMARK 465     LYS I   253
REMARK 465     LYS I   254
REMARK 465     GLU I   255
REMARK 465     ILE I   256
REMARK 465     ASN I   257
REMARK 465     GLY I   258
REMARK 465     THR I   259
REMARK 465     ASP I   260
REMARK 465     SER I   261
REMARK 465     GLY I   262
REMARK 465     ASN I   263
REMARK 465     SER I   264
REMARK 465     HIS I   265
REMARK 465     ARG I   266
REMARK 465     ALA I   267
REMARK 465     SER I   383
REMARK 465     LEU I   384
REMARK 465     MET I   385
REMARK 465     MET J   -58
REMARK 465     LEU J   -57
REMARK 465     PRO J   -56
REMARK 465     SER J   -55
REMARK 465     ALA J   -54
REMARK 465     GLN J   -53
REMARK 465     VAL J   -52
REMARK 465     ALA J   -51
REMARK 465     ARG J   -50
REMARK 465     LEU J   -49
REMARK 465     LYS J   -48
REMARK 465     PRO J   -47
REMARK 465     ASP J   -46
REMARK 465     PRO J   -45
REMARK 465     PHE J   -44
REMARK 465     PRO J   -43
REMARK 465     PRO J   -42
REMARK 465     SER J   -41
REMARK 465     LEU J   -40
REMARK 465     SER J   -39
REMARK 465     PRO J   -38
REMARK 465     ILE J   -37
REMARK 465     PRO J   -36
REMARK 465     HIS J   -35
REMARK 465     GLY J   -34
REMARK 465     ALA J   -33
REMARK 465     VAL J   -32
REMARK 465     THR J   -31
REMARK 465     PHE J   -30
REMARK 465     ALA J   -29
REMARK 465     ALA J   -28
REMARK 465     LEU J   -27
REMARK 465     ALA J   -26
REMARK 465     PRO J   -25
REMARK 465     CYS J   -24
REMARK 465     HIS J   -23
REMARK 465     ASN J   -22
REMARK 465     LEU J   -21
REMARK 465     PRO J   -20
REMARK 465     ILE J   -19
REMARK 465     PHE J   -18
REMARK 465     SER J   -17
REMARK 465     SER J   -16
REMARK 465     ARG J   -15
REMARK 465     GLN J   -14
REMARK 465     MET J   -13
REMARK 465     LEU J   -12
REMARK 465     ARG J   -11
REMARK 465     ASP J   -10
REMARK 465     SER J    -9
REMARK 465     LEU J    -8
REMARK 465     THR J    -7
REMARK 465     TYR J    -6
REMARK 465     SER J    -5
REMARK 465     HIS J    -4
REMARK 465     THR J    -3
REMARK 465     SER J    -2
REMARK 465     PRO J    -1
REMARK 465     THR J     0
REMARK 465     MET J     1
REMARK 465     SER J     2
REMARK 465     PRO J     3
REMARK 465     GLN J     4
REMARK 465     ILE J     5
REMARK 465     ALA J     6
REMARK 465     GLU J   109
REMARK 465     GLY J   110
REMARK 465     GLN J   111
REMARK 465     ARG J   112
REMARK 465     ALA J   238
REMARK 465     PRO J   239
REMARK 465     GLY J   240
REMARK 465     VAL J   241
REMARK 465     GLN J   242
REMARK 465     ALA J   243
REMARK 465     GLY J   244
REMARK 465     ARG J   245
REMARK 465     ASN J   246
REMARK 465     ILE J   247
REMARK 465     SER J   248
REMARK 465     SER J   249
REMARK 465     GLN J   250
REMARK 465     ASP J   251
REMARK 465     ALA J   252
REMARK 465     LYS J   253
REMARK 465     LYS J   254
REMARK 465     GLU J   255
REMARK 465     ILE J   256
REMARK 465     ASN J   257
REMARK 465     GLY J   258
REMARK 465     THR J   259
REMARK 465     ASP J   260
REMARK 465     SER J   261
REMARK 465     GLY J   262
REMARK 465     ASN J   263
REMARK 465     SER J   264
REMARK 465     HIS J   265
REMARK 465     ARG J   266
REMARK 465     ALA J   267
REMARK 465     MET J   385
REMARK 465     MET K   -58
REMARK 465     LEU K   -57
REMARK 465     PRO K   -56
REMARK 465     SER K   -55
REMARK 465     ALA K   -54
REMARK 465     GLN K   -53
REMARK 465     VAL K   -52
REMARK 465     ALA K   -51
REMARK 465     ARG K   -50
REMARK 465     LEU K   -49
REMARK 465     LYS K   -48
REMARK 465     PRO K   -47
REMARK 465     ASP K   -46
REMARK 465     PRO K   -45
REMARK 465     PHE K   -44
REMARK 465     PRO K   -43
REMARK 465     PRO K   -42
REMARK 465     SER K   -41
REMARK 465     LEU K   -40
REMARK 465     SER K   -39
REMARK 465     PRO K   -38
REMARK 465     ILE K   -37
REMARK 465     PRO K   -36
REMARK 465     HIS K   -35
REMARK 465     GLY K   -34
REMARK 465     ALA K   -33
REMARK 465     VAL K   -32
REMARK 465     THR K   -31
REMARK 465     PHE K   -30
REMARK 465     ALA K   -29
REMARK 465     ALA K   -28
REMARK 465     LEU K   -27
REMARK 465     ALA K   -26
REMARK 465     PRO K   -25
REMARK 465     CYS K   -24
REMARK 465     HIS K   -23
REMARK 465     ASN K   -22
REMARK 465     LEU K   -21
REMARK 465     PRO K   -20
REMARK 465     ILE K   -19
REMARK 465     PHE K   -18
REMARK 465     SER K   -17
REMARK 465     SER K   -16
REMARK 465     ARG K   -15
REMARK 465     GLN K   -14
REMARK 465     MET K   -13
REMARK 465     LEU K   -12
REMARK 465     ARG K   -11
REMARK 465     ASP K   -10
REMARK 465     SER K    -9
REMARK 465     LEU K    -8
REMARK 465     THR K    -7
REMARK 465     TYR K    -6
REMARK 465     SER K    -5
REMARK 465     HIS K    -4
REMARK 465     THR K    -3
REMARK 465     SER K    -2
REMARK 465     PRO K    -1
REMARK 465     THR K     0
REMARK 465     MET K     1
REMARK 465     SER K     2
REMARK 465     PRO K     3
REMARK 465     GLN K     4
REMARK 465     ILE K     5
REMARK 465     ALA K     6
REMARK 465     GLU K   109
REMARK 465     GLY K   110
REMARK 465     GLN K   111
REMARK 465     ARG K   112
REMARK 465     ALA K   238
REMARK 465     PRO K   239
REMARK 465     GLY K   240
REMARK 465     VAL K   241
REMARK 465     GLN K   242
REMARK 465     ALA K   243
REMARK 465     GLY K   244
REMARK 465     ARG K   245
REMARK 465     ASN K   246
REMARK 465     ILE K   247
REMARK 465     SER K   248
REMARK 465     SER K   249
REMARK 465     GLN K   250
REMARK 465     ASP K   251
REMARK 465     ALA K   252
REMARK 465     LYS K   253
REMARK 465     LYS K   254
REMARK 465     GLU K   255
REMARK 465     ILE K   256
REMARK 465     ASN K   257
REMARK 465     GLY K   258
REMARK 465     THR K   259
REMARK 465     ASP K   260
REMARK 465     SER K   261
REMARK 465     GLY K   262
REMARK 465     ASN K   263
REMARK 465     SER K   264
REMARK 465     HIS K   265
REMARK 465     ARG K   266
REMARK 465     ALA K   267
REMARK 465     MET K   385
REMARK 465     MET L   -58
REMARK 465     LEU L   -57
REMARK 465     PRO L   -56
REMARK 465     SER L   -55
REMARK 465     ALA L   -54
REMARK 465     GLN L   -53
REMARK 465     VAL L   -52
REMARK 465     ALA L   -51
REMARK 465     ARG L   -50
REMARK 465     LEU L   -49
REMARK 465     LYS L   -48
REMARK 465     PRO L   -47
REMARK 465     ASP L   -46
REMARK 465     PRO L   -45
REMARK 465     PHE L   -44
REMARK 465     PRO L   -43
REMARK 465     PRO L   -42
REMARK 465     SER L   -41
REMARK 465     LEU L   -40
REMARK 465     SER L   -39
REMARK 465     PRO L   -38
REMARK 465     ILE L   -37
REMARK 465     PRO L   -36
REMARK 465     HIS L   -35
REMARK 465     GLY L   -34
REMARK 465     ALA L   -33
REMARK 465     VAL L   -32
REMARK 465     THR L   -31
REMARK 465     PHE L   -30
REMARK 465     ALA L   -29
REMARK 465     ALA L   -28
REMARK 465     LEU L   -27
REMARK 465     ALA L   -26
REMARK 465     PRO L   -25
REMARK 465     CYS L   -24
REMARK 465     HIS L   -23
REMARK 465     ASN L   -22
REMARK 465     LEU L   -21
REMARK 465     PRO L   -20
REMARK 465     ILE L   -19
REMARK 465     PHE L   -18
REMARK 465     SER L   -17
REMARK 465     SER L   -16
REMARK 465     ARG L   -15
REMARK 465     GLN L   -14
REMARK 465     MET L   -13
REMARK 465     LEU L   -12
REMARK 465     ARG L   -11
REMARK 465     ASP L   -10
REMARK 465     SER L    -9
REMARK 465     LEU L    -8
REMARK 465     THR L    -7
REMARK 465     TYR L    -6
REMARK 465     SER L    -5
REMARK 465     HIS L    -4
REMARK 465     THR L    -3
REMARK 465     SER L    -2
REMARK 465     PRO L    -1
REMARK 465     THR L     0
REMARK 465     MET L     1
REMARK 465     SER L     2
REMARK 465     PRO L     3
REMARK 465     GLN L     4
REMARK 465     ILE L     5
REMARK 465     ALA L     6
REMARK 465     ALA L   108
REMARK 465     GLU L   109
REMARK 465     GLY L   110
REMARK 465     GLN L   111
REMARK 465     ARG L   112
REMARK 465     ALA L   238
REMARK 465     PRO L   239
REMARK 465     GLY L   240
REMARK 465     VAL L   241
REMARK 465     GLN L   242
REMARK 465     ALA L   243
REMARK 465     GLY L   244
REMARK 465     ARG L   245
REMARK 465     ASN L   246
REMARK 465     ILE L   247
REMARK 465     SER L   248
REMARK 465     SER L   249
REMARK 465     GLN L   250
REMARK 465     ASP L   251
REMARK 465     ALA L   252
REMARK 465     LYS L   253
REMARK 465     LYS L   254
REMARK 465     GLU L   255
REMARK 465     ILE L   256
REMARK 465     ASN L   257
REMARK 465     GLY L   258
REMARK 465     THR L   259
REMARK 465     ASP L   260
REMARK 465     SER L   261
REMARK 465     GLY L   262
REMARK 465     ASN L   263
REMARK 465     SER L   264
REMARK 465     HIS L   265
REMARK 465     ARG L   266
REMARK 465     ALA L   267
REMARK 465     SER L   383
REMARK 465     LEU L   384
REMARK 465     MET L   385
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   OG1  THR B   303  -  O    HOH B  2124              2.16
REMARK 500   O    ARG C    20  -  NH1  ARG C   136              2.08
REMARK 500   NE1  TRP D    68  -  O    HOH D  2029              2.18
REMARK 500   OD1  ASP E    14  -  O    HOH E  2005              1.72
REMARK 500   N    GLY E   268  -  N6A  COA E  1383              2.03
REMARK 500   OG   SER F   332  -  O    GLU F   360              2.05
REMARK 500   OG   SER G   332  -  O    GLU G   360              2.13
REMARK 500   OG1  THR H   303  -  O    HOH H  2117              1.67
REMARK 500   OG   SER H   332  -  O    GLU H   360              2.01
REMARK 500   OH   TYR J   280  -  O7A  COA J  1385              2.17
REMARK 500   O    GLU J   360  -  O    HOH J  2076              1.89
REMARK 500   OG   SER L   332  -  O    GLU L   360              2.06
REMARK 500   O9A  COA B  1383  -  O    HOH B  2170              2.01
REMARK 500   O2B  COA H  1383  -  O    HOH H  2144              2.04
REMARK 500   O    HOH I  2042  -  O    HOH I  2160              2.07
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,1X,2(A4,A1,3X),12X,F5.3)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCELIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION
REMARK 500    LEU A 326   CG    LEU A 326   CD2    -0.313
REMARK 500    ARG B   8   CZ    ARG B   8   NH1    -0.121
REMARK 500    ARG B   8   CZ    ARG B   8   NH2    -0.110
REMARK 500    PHE B 186   CE1   PHE B 186   CZ     -0.223
REMARK 500    PHE B 186   CE2   PHE B 186   CZ     -0.188
REMARK 500    PHE B 186   CG    PHE B 186   CD1    -0.140
REMARK 500    PHE B 186   CG    PHE B 186   CD2    -0.168
REMARK 500    ASN B 373   CG    ASN B 373   OD1    -0.133
REMARK 500    GLN C 189   CD    GLN C 189   NE2    -0.158
REMARK 500    GLN C 191   CD    GLN C 191   NE2    -0.154
REMARK 500    GLU D  27   CD    GLU D  27   OE1    -0.108
REMARK 500    GLU D  27   CD    GLU D  27   OE2    -0.081
REMARK 500    LEU D 200   CG    LEU D 200   CD2    -0.235
REMARK 500    GLU D 340   CD    GLU D 340   OE1    -0.117
REMARK 500    GLU D 340   CD    GLU D 340   OE2    -0.116
REMARK 500    ARG F 190   CZ    ARG F 190   NH1    -0.120
REMARK 500    ARG F 190   CZ    ARG F 190   NH2    -0.092
REMARK 500    GLU J  27   CD    GLU J  27   OE1    -0.096
REMARK 500    GLU J  27   CD    GLU J  27   OE2    -0.081
REMARK 500    CYS F 176   CB    CYS F 176   SG     -0.103
REMARK 500    CYS G 102   CB    CYS G 102   SG     -0.098
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCELIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    ARG A 177   NE  -  CZ  -  NH1 ANGL. DEV. =   5.7 DEGREES
REMARK 500    ARG A 177   NE  -  CZ  -  NH2 ANGL. DEV. =  -4.2 DEGREES
REMARK 500    LEU A 326   CD1 -  CG  -  CD2 ANGL. DEV. = -23.6 DEGREES
REMARK 500    ARG B   8   NE  -  CZ  -  NH1 ANGL. DEV. =   3.7 DEGREES
REMARK 500    ARG B   8   NE  -  CZ  -  NH2 ANGL. DEV. =   5.2 DEGREES
REMARK 500    ARG B   8   NH1 -  CZ  -  NH2 ANGL. DEV. =  -8.9 DEGREES
REMARK 500    ARG C 310   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.4 DEGREES
REMARK 500    GLU D  27   OE1 -  CD  -  OE2 ANGL. DEV. = -11.9 DEGREES
REMARK 500    GLU D 340   OE1 -  CD  -  OE2 ANGL. DEV. = -12.0 DEGREES
REMARK 500    ARG F 190   NE  -  CZ  -  NH1 ANGL. DEV. =   4.6 DEGREES
REMARK 500    ARG F 190   NE  -  CZ  -  NH2 ANGL. DEV. =   3.6 DEGREES
REMARK 500    ARG F 190   NH1 -  CZ  -  NH2 ANGL. DEV. =  -8.2 DEGREES
REMARK 500    MET G 297   CG  -  SD  -  CE  ANGL. DEV. =  10.5 DEGREES
REMARK 500    MET H 297   CG  -  SD  -  CE  ANGL. DEV. =  10.4 DEGREES
REMARK 500    ARG H 310   NE  -  CZ  -  NH1 ANGL. DEV. =   3.0 DEGREES
REMARK 500    ARG H 310   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.2 DEGREES
REMARK 500    GLU J  27   OE1 -  CD  -  OE2 ANGL. DEV. = -11.7 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ALA A 108       -5.92   -158.66
REMARK 500    SER A 149     -122.56     67.66
REMARK 500    LYS A 226     -158.01   -104.90
REMARK 500    ASP A 305      102.71   -172.02
REMARK 500    ASN A 350       73.41   -115.92
REMARK 500    GLU A 368       41.00   -106.24
REMARK 500    SER B 149     -119.59     65.60
REMARK 500    LYS B 226     -165.32   -104.73
REMARK 500    GLN B 269      -29.60   -153.48
REMARK 500    ASP B 305      109.94   -169.11
REMARK 500    ASN B 350       70.44   -115.91
REMARK 500    GLU B 368       40.64   -102.91
REMARK 500    ASP C 107       30.72    -82.98
REMARK 500    ALA C 108       16.27   -154.62
REMARK 500    SER C 149     -122.63     67.35
REMARK 500    LYS C 226     -169.00   -107.41
REMARK 500    ASP C 305      106.01   -173.99
REMARK 500    ASN C 350       71.58   -119.15
REMARK 500    SER D 149     -120.12     65.22
REMARK 500    LYS D 226     -167.17   -101.06
REMARK 500    ASP D 305      109.74   -170.94
REMARK 500    ASN D 350       72.73   -118.11
REMARK 500    ASP D 363       -9.32    -56.78
REMARK 500    SER E 149     -123.70     65.35
REMARK 500    LYS E 226     -159.87   -107.69
REMARK 500    GLN E 269      -26.56   -149.81
REMARK 500    ASP E 305      102.09   -171.18
REMARK 500    ASN E 350       72.28   -116.44
REMARK 500    ASP E 363       -6.84    -58.91
REMARK 500    THR F  81        0.02    -69.18
REMARK 500    SER F 149     -124.07     65.00
REMARK 500    LYS F 226     -169.54   -108.24
REMARK 500    ASP F 305      108.31   -167.87
REMARK 500    ASN F 350       74.00   -111.50
REMARK 500    ASP F 363      -13.65    -48.81
REMARK 500    ASP G  14      171.41    -59.39
REMARK 500    SER G 149     -121.57     67.32
REMARK 500    ASP G 305      110.71   -167.33
REMARK 500    ASN G 350       70.86   -114.18
REMARK 500    GLU G 368       43.79   -106.42
REMARK 500    SER H 149     -121.48     67.04
REMARK 500    ASP H 305      108.59   -167.02
REMARK 500    ASN H 350       69.97   -113.82
REMARK 500    GLU H 368       45.72   -106.79
REMARK 500    SER I 149     -118.95     67.04
REMARK 500    LYS I 226     -164.81   -104.03
REMARK 500    GLN I 269      -21.38   -150.56
REMARK 500    ASP I 305      107.95   -169.29
REMARK 500    ASN I 350       74.55   -113.10
REMARK 500    GLU I 368       43.70   -102.78
REMARK 500    ASN J  46     -168.35    -77.42
REMARK 500    SER J 149     -117.89     72.62
REMARK 500    ASP J 305      105.91   -172.02
REMARK 500    ASN J 350       64.64   -112.39
REMARK 500    SER K 149     -121.90     70.00
REMARK 500    LYS K 226     -169.32   -100.40
REMARK 500    ASP K 305      107.43   -169.50
REMARK 500    ASN K 350       63.28   -110.86
REMARK 500    ASP K 363       -7.44    -58.57
REMARK 500    GLU K 368       41.34   -105.70
REMARK 500    THR L  81        2.04    -69.69
REMARK 500    SER L 149     -122.58     63.61
REMARK 500    LYS L 226     -165.90   -103.81
REMARK 500    GLN L 269      -35.20   -141.48
REMARK 500    ASP L 305      107.81   -168.08
REMARK 500    ASN L 350       76.07   -110.65
REMARK 500    GLU L 368       43.41   -107.28
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500                                 MODEL     OMEGA
REMARK 500 GLY L  268     GLN L  269          0       147.64
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE COA A 1383
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE COA B 1383
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE COA C 1383
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE COA D 1383
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE COA E 1383
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE COA F 1383
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE COA G 1383
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE COA H 1383
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC9
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE COA I 1383
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC1
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE COA J 1385
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC2
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE COA K 1385
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC3
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE COA L 1383
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC4
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 1384
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC5
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL I 1384
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC6
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT A 1384
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC7
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT B 1385
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC8
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT E 1384
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC9
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT I 1385
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC1
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT H 1384
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC2
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT G 1384
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC3
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT D 1384
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC4
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT C 1384
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC5
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT F 1384
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC6
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT J 1386
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC7
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT K 1386
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC8
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT L 1384
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 2VAV   RELATED DB: PDB
REMARK 900  CRYSTAL STRUCTURE OF DEACETYLCEPHALOSPORIN C
REMARK 900  ACETYLTRANSFERASE (COMPLEX I)
REMARK 900 RELATED ID: 2VAX   RELATED DB: PDB
REMARK 900  CRYSTAL STRUCTURE OF DEACETYLCEPHALOSPORIN C
REMARK 900  ACETYLTRANSFERASE (COMPLEX II)
DBREF  2VAT A  -58   385  UNP    P39058   CEFG_CEPAC       1    444
DBREF  2VAT B  -58   385  UNP    P39058   CEFG_CEPAC       1    444
DBREF  2VAT C  -58   385  UNP    P39058   CEFG_CEPAC       1    444
DBREF  2VAT D  -58   385  UNP    P39058   CEFG_CEPAC       1    444
DBREF  2VAT E  -58   385  UNP    P39058   CEFG_CEPAC       1    444
DBREF  2VAT F  -58   385  UNP    P39058   CEFG_CEPAC       1    444
DBREF  2VAT G  -58   385  UNP    P39058   CEFG_CEPAC       1    444
DBREF  2VAT H  -58   385  UNP    P39058   CEFG_CEPAC       1    444
DBREF  2VAT I  -58   385  UNP    P39058   CEFG_CEPAC       1    444
DBREF  2VAT J  -58   385  UNP    P39058   CEFG_CEPAC       1    444
DBREF  2VAT K  -58   385  UNP    P39058   CEFG_CEPAC       1    444
DBREF  2VAT L  -58   385  UNP    P39058   CEFG_CEPAC       1    444
SEQRES   1 A  444  MET LEU PRO SER ALA GLN VAL ALA ARG LEU LYS PRO ASP
SEQRES   2 A  444  PRO PHE PRO PRO SER LEU SER PRO ILE PRO HIS GLY ALA
SEQRES   3 A  444  VAL THR PHE ALA ALA LEU ALA PRO CYS HIS ASN LEU PRO
SEQRES   4 A  444  ILE PHE SER SER ARG GLN MET LEU ARG ASP SER LEU THR
SEQRES   5 A  444  TYR SER HIS THR SER PRO THR MET SER PRO GLN ILE ALA
SEQRES   6 A  444  ASN ARG PHE GLU ALA SER LEU ASP ALA GLN ASP ILE ALA
SEQRES   7 A  444  ARG ILE SER LEU PHE THR LEU GLU SER GLY VAL ILE LEU
SEQRES   8 A  444  ARG ASP VAL PRO VAL ALA TYR LYS SER TRP GLY ARG MET
SEQRES   9 A  444  ASN VAL SER ARG ASP ASN CYS VAL ILE VAL CYS HIS THR
SEQRES  10 A  444  LEU THR SER SER ALA HIS VAL THR SER TRP TRP PRO THR
SEQRES  11 A  444  LEU PHE GLY GLN GLY ARG ALA PHE ASP THR SER ARG TYR
SEQRES  12 A  444  PHE ILE ILE CYS LEU ASN TYR LEU GLY SER PRO PHE GLY
SEQRES  13 A  444  SER ALA GLY PRO CYS SER PRO ASP PRO ASP ALA GLU GLY
SEQRES  14 A  444  GLN ARG PRO TYR GLY ALA LYS PHE PRO ARG THR THR ILE
SEQRES  15 A  444  ARG ASP ASP VAL ARG ILE HIS ARG GLN VAL LEU ASP ARG
SEQRES  16 A  444  LEU GLY VAL ARG GLN ILE ALA ALA VAL VAL GLY ALA SER
SEQRES  17 A  444  MET GLY GLY MET HIS THR LEU GLU TRP ALA PHE PHE GLY
SEQRES  18 A  444  PRO GLU TYR VAL ARG LYS ILE VAL PRO ILE ALA THR SER
SEQRES  19 A  444  CYS ARG GLN SER GLY TRP CYS ALA ALA TRP PHE GLU THR
SEQRES  20 A  444  GLN ARG GLN CYS ILE TYR ASP ASP PRO LYS TYR LEU ASP
SEQRES  21 A  444  GLY GLU TYR ASP VAL ASP ASP GLN PRO VAL ARG GLY LEU
SEQRES  22 A  444  GLU THR ALA ARG LYS ILE ALA ASN LEU THR TYR LYS SER
SEQRES  23 A  444  LYS PRO ALA MET ASP GLU ARG PHE HIS MET ALA PRO GLY
SEQRES  24 A  444  VAL GLN ALA GLY ARG ASN ILE SER SER GLN ASP ALA LYS
SEQRES  25 A  444  LYS GLU ILE ASN GLY THR ASP SER GLY ASN SER HIS ARG
SEQRES  26 A  444  ALA GLY GLN PRO ILE GLU ALA VAL SER SER TYR LEU ARG
SEQRES  27 A  444  TYR GLN ALA GLN LYS PHE ALA ALA SER PHE ASP ALA ASN
SEQRES  28 A  444  CYS TYR ILE ALA MET THR LEU LYS PHE ASP THR HIS ASP
SEQRES  29 A  444  ILE SER ARG GLY ARG ALA GLY SER ILE PRO GLU ALA LEU
SEQRES  30 A  444  ALA MET ILE THR GLN PRO ALA LEU ILE ILE CYS ALA ARG
SEQRES  31 A  444  SER ASP GLY LEU TYR SER PHE ASP GLU HIS VAL GLU MET
SEQRES  32 A  444  GLY ARG SER ILE PRO ASN SER ARG LEU CYS VAL VAL ASP
SEQRES  33 A  444  THR ASN GLU GLY HIS ASP PHE PHE VAL MET GLU ALA ASP
SEQRES  34 A  444  LYS VAL ASN ASP ALA VAL ARG GLY PHE LEU ASP GLN SER
SEQRES  35 A  444  LEU MET
SEQRES   1 B  444  MET LEU PRO SER ALA GLN VAL ALA ARG LEU LYS PRO ASP
SEQRES   2 B  444  PRO PHE PRO PRO SER LEU SER PRO ILE PRO HIS GLY ALA
SEQRES   3 B  444  VAL THR PHE ALA ALA LEU ALA PRO CYS HIS ASN LEU PRO
SEQRES   4 B  444  ILE PHE SER SER ARG GLN MET LEU ARG ASP SER LEU THR
SEQRES   5 B  444  TYR SER HIS THR SER PRO THR MET SER PRO GLN ILE ALA
SEQRES   6 B  444  ASN ARG PHE GLU ALA SER LEU ASP ALA GLN ASP ILE ALA
SEQRES   7 B  444  ARG ILE SER LEU PHE THR LEU GLU SER GLY VAL ILE LEU
SEQRES   8 B  444  ARG ASP VAL PRO VAL ALA TYR LYS SER TRP GLY ARG MET
SEQRES   9 B  444  ASN VAL SER ARG ASP ASN CYS VAL ILE VAL CYS HIS THR
SEQRES  10 B  444  LEU THR SER SER ALA HIS VAL THR SER TRP TRP PRO THR
SEQRES  11 B  444  LEU PHE GLY GLN GLY ARG ALA PHE ASP THR SER ARG TYR
SEQRES  12 B  444  PHE ILE ILE CYS LEU ASN TYR LEU GLY SER PRO PHE GLY
SEQRES  13 B  444  SER ALA GLY PRO CYS SER PRO ASP PRO ASP ALA GLU GLY
SEQRES  14 B  444  GLN ARG PRO TYR GLY ALA LYS PHE PRO ARG THR THR ILE
SEQRES  15 B  444  ARG ASP ASP VAL ARG ILE HIS ARG GLN VAL LEU ASP ARG
SEQRES  16 B  444  LEU GLY VAL ARG GLN ILE ALA ALA VAL VAL GLY ALA SER
SEQRES  17 B  444  MET GLY GLY MET HIS THR LEU GLU TRP ALA PHE PHE GLY
SEQRES  18 B  444  PRO GLU TYR VAL ARG LYS ILE VAL PRO ILE ALA THR SER
SEQRES  19 B  444  CYS ARG GLN SER GLY TRP CYS ALA ALA TRP PHE GLU THR
SEQRES  20 B  444  GLN ARG GLN CYS ILE TYR ASP ASP PRO LYS TYR LEU ASP
SEQRES  21 B  444  GLY GLU TYR ASP VAL ASP ASP GLN PRO VAL ARG GLY LEU
SEQRES  22 B  444  GLU THR ALA ARG LYS ILE ALA ASN LEU THR TYR LYS SER
SEQRES  23 B  444  LYS PRO ALA MET ASP GLU ARG PHE HIS MET ALA PRO GLY
SEQRES  24 B  444  VAL GLN ALA GLY ARG ASN ILE SER SER GLN ASP ALA LYS
SEQRES  25 B  444  LYS GLU ILE ASN GLY THR ASP SER GLY ASN SER HIS ARG
SEQRES  26 B  444  ALA GLY GLN PRO ILE GLU ALA VAL SER SER TYR LEU ARG
SEQRES  27 B  444  TYR GLN ALA GLN LYS PHE ALA ALA SER PHE ASP ALA ASN
SEQRES  28 B  444  CYS TYR ILE ALA MET THR LEU LYS PHE ASP THR HIS ASP
SEQRES  29 B  444  ILE SER ARG GLY ARG ALA GLY SER ILE PRO GLU ALA LEU
SEQRES  30 B  444  ALA MET ILE THR GLN PRO ALA LEU ILE ILE CYS ALA ARG
SEQRES  31 B  444  SER ASP GLY LEU TYR SER PHE ASP GLU HIS VAL GLU MET
SEQRES  32 B  444  GLY ARG SER ILE PRO ASN SER ARG LEU CYS VAL VAL ASP
SEQRES  33 B  444  THR ASN GLU GLY HIS ASP PHE PHE VAL MET GLU ALA ASP
SEQRES  34 B  444  LYS VAL ASN ASP ALA VAL ARG GLY PHE LEU ASP GLN SER
SEQRES  35 B  444  LEU MET
SEQRES   1 C  444  MET LEU PRO SER ALA GLN VAL ALA ARG LEU LYS PRO ASP
SEQRES   2 C  444  PRO PHE PRO PRO SER LEU SER PRO ILE PRO HIS GLY ALA
SEQRES   3 C  444  VAL THR PHE ALA ALA LEU ALA PRO CYS HIS ASN LEU PRO
SEQRES   4 C  444  ILE PHE SER SER ARG GLN MET LEU ARG ASP SER LEU THR
SEQRES   5 C  444  TYR SER HIS THR SER PRO THR MET SER PRO GLN ILE ALA
SEQRES   6 C  444  ASN ARG PHE GLU ALA SER LEU ASP ALA GLN ASP ILE ALA
SEQRES   7 C  444  ARG ILE SER LEU PHE THR LEU GLU SER GLY VAL ILE LEU
SEQRES   8 C  444  ARG ASP VAL PRO VAL ALA TYR LYS SER TRP GLY ARG MET
SEQRES   9 C  444  ASN VAL SER ARG ASP ASN CYS VAL ILE VAL CYS HIS THR
SEQRES  10 C  444  LEU THR SER SER ALA HIS VAL THR SER TRP TRP PRO THR
SEQRES  11 C  444  LEU PHE GLY GLN GLY ARG ALA PHE ASP THR SER ARG TYR
SEQRES  12 C  444  PHE ILE ILE CYS LEU ASN TYR LEU GLY SER PRO PHE GLY
SEQRES  13 C  444  SER ALA GLY PRO CYS SER PRO ASP PRO ASP ALA GLU GLY
SEQRES  14 C  444  GLN ARG PRO TYR GLY ALA LYS PHE PRO ARG THR THR ILE
SEQRES  15 C  444  ARG ASP ASP VAL ARG ILE HIS ARG GLN VAL LEU ASP ARG
SEQRES  16 C  444  LEU GLY VAL ARG GLN ILE ALA ALA VAL VAL GLY ALA SER
SEQRES  17 C  444  MET GLY GLY MET HIS THR LEU GLU TRP ALA PHE PHE GLY
SEQRES  18 C  444  PRO GLU TYR VAL ARG LYS ILE VAL PRO ILE ALA THR SER
SEQRES  19 C  444  CYS ARG GLN SER GLY TRP CYS ALA ALA TRP PHE GLU THR
SEQRES  20 C  444  GLN ARG GLN CYS ILE TYR ASP ASP PRO LYS TYR LEU ASP
SEQRES  21 C  444  GLY GLU TYR ASP VAL ASP ASP GLN PRO VAL ARG GLY LEU
SEQRES  22 C  444  GLU THR ALA ARG LYS ILE ALA ASN LEU THR TYR LYS SER
SEQRES  23 C  444  LYS PRO ALA MET ASP GLU ARG PHE HIS MET ALA PRO GLY
SEQRES  24 C  444  VAL GLN ALA GLY ARG ASN ILE SER SER GLN ASP ALA LYS
SEQRES  25 C  444  LYS GLU ILE ASN GLY THR ASP SER GLY ASN SER HIS ARG
SEQRES  26 C  444  ALA GLY GLN PRO ILE GLU ALA VAL SER SER TYR LEU ARG
SEQRES  27 C  444  TYR GLN ALA GLN LYS PHE ALA ALA SER PHE ASP ALA ASN
SEQRES  28 C  444  CYS TYR ILE ALA MET THR LEU LYS PHE ASP THR HIS ASP
SEQRES  29 C  444  ILE SER ARG GLY ARG ALA GLY SER ILE PRO GLU ALA LEU
SEQRES  30 C  444  ALA MET ILE THR GLN PRO ALA LEU ILE ILE CYS ALA ARG
SEQRES  31 C  444  SER ASP GLY LEU TYR SER PHE ASP GLU HIS VAL GLU MET
SEQRES  32 C  444  GLY ARG SER ILE PRO ASN SER ARG LEU CYS VAL VAL ASP
SEQRES  33 C  444  THR ASN GLU GLY HIS ASP PHE PHE VAL MET GLU ALA ASP
SEQRES  34 C  444  LYS VAL ASN ASP ALA VAL ARG GLY PHE LEU ASP GLN SER
SEQRES  35 C  444  LEU MET
SEQRES   1 D  444  MET LEU PRO SER ALA GLN VAL ALA ARG LEU LYS PRO ASP
SEQRES   2 D  444  PRO PHE PRO PRO SER LEU SER PRO ILE PRO HIS GLY ALA
SEQRES   3 D  444  VAL THR PHE ALA ALA LEU ALA PRO CYS HIS ASN LEU PRO
SEQRES   4 D  444  ILE PHE SER SER ARG GLN MET LEU ARG ASP SER LEU THR
SEQRES   5 D  444  TYR SER HIS THR SER PRO THR MET SER PRO GLN ILE ALA
SEQRES   6 D  444  ASN ARG PHE GLU ALA SER LEU ASP ALA GLN ASP ILE ALA
SEQRES   7 D  444  ARG ILE SER LEU PHE THR LEU GLU SER GLY VAL ILE LEU
SEQRES   8 D  444  ARG ASP VAL PRO VAL ALA TYR LYS SER TRP GLY ARG MET
SEQRES   9 D  444  ASN VAL SER ARG ASP ASN CYS VAL ILE VAL CYS HIS THR
SEQRES  10 D  444  LEU THR SER SER ALA HIS VAL THR SER TRP TRP PRO THR
SEQRES  11 D  444  LEU PHE GLY GLN GLY ARG ALA PHE ASP THR SER ARG TYR
SEQRES  12 D  444  PHE ILE ILE CYS LEU ASN TYR LEU GLY SER PRO PHE GLY
SEQRES  13 D  444  SER ALA GLY PRO CYS SER PRO ASP PRO ASP ALA GLU GLY
SEQRES  14 D  444  GLN ARG PRO TYR GLY ALA LYS PHE PRO ARG THR THR ILE
SEQRES  15 D  444  ARG ASP ASP VAL ARG ILE HIS ARG GLN VAL LEU ASP ARG
SEQRES  16 D  444  LEU GLY VAL ARG GLN ILE ALA ALA VAL VAL GLY ALA SER
SEQRES  17 D  444  MET GLY GLY MET HIS THR LEU GLU TRP ALA PHE PHE GLY
SEQRES  18 D  444  PRO GLU TYR VAL ARG LYS ILE VAL PRO ILE ALA THR SER
SEQRES  19 D  444  CYS ARG GLN SER GLY TRP CYS ALA ALA TRP PHE GLU THR
SEQRES  20 D  444  GLN ARG GLN CYS ILE TYR ASP ASP PRO LYS TYR LEU ASP
SEQRES  21 D  444  GLY GLU TYR ASP VAL ASP ASP GLN PRO VAL ARG GLY LEU
SEQRES  22 D  444  GLU THR ALA ARG LYS ILE ALA ASN LEU THR TYR LYS SER
SEQRES  23 D  444  LYS PRO ALA MET ASP GLU ARG PHE HIS MET ALA PRO GLY
SEQRES  24 D  444  VAL GLN ALA GLY ARG ASN ILE SER SER GLN ASP ALA LYS
SEQRES  25 D  444  LYS GLU ILE ASN GLY THR ASP SER GLY ASN SER HIS ARG
SEQRES  26 D  444  ALA GLY GLN PRO ILE GLU ALA VAL SER SER TYR LEU ARG
SEQRES  27 D  444  TYR GLN ALA GLN LYS PHE ALA ALA SER PHE ASP ALA ASN
SEQRES  28 D  444  CYS TYR ILE ALA MET THR LEU LYS PHE ASP THR HIS ASP
SEQRES  29 D  444  ILE SER ARG GLY ARG ALA GLY SER ILE PRO GLU ALA LEU
SEQRES  30 D  444  ALA MET ILE THR GLN PRO ALA LEU ILE ILE CYS ALA ARG
SEQRES  31 D  444  SER ASP GLY LEU TYR SER PHE ASP GLU HIS VAL GLU MET
SEQRES  32 D  444  GLY ARG SER ILE PRO ASN SER ARG LEU CYS VAL VAL ASP
SEQRES  33 D  444  THR ASN GLU GLY HIS ASP PHE PHE VAL MET GLU ALA ASP
SEQRES  34 D  444  LYS VAL ASN ASP ALA VAL ARG GLY PHE LEU ASP GLN SER
SEQRES  35 D  444  LEU MET
SEQRES   1 E  444  MET LEU PRO SER ALA GLN VAL ALA ARG LEU LYS PRO ASP
SEQRES   2 E  444  PRO PHE PRO PRO SER LEU SER PRO ILE PRO HIS GLY ALA
SEQRES   3 E  444  VAL THR PHE ALA ALA LEU ALA PRO CYS HIS ASN LEU PRO
SEQRES   4 E  444  ILE PHE SER SER ARG GLN MET LEU ARG ASP SER LEU THR
SEQRES   5 E  444  TYR SER HIS THR SER PRO THR MET SER PRO GLN ILE ALA
SEQRES   6 E  444  ASN ARG PHE GLU ALA SER LEU ASP ALA GLN ASP ILE ALA
SEQRES   7 E  444  ARG ILE SER LEU PHE THR LEU GLU SER GLY VAL ILE LEU
SEQRES   8 E  444  ARG ASP VAL PRO VAL ALA TYR LYS SER TRP GLY ARG MET
SEQRES   9 E  444  ASN VAL SER ARG ASP ASN CYS VAL ILE VAL CYS HIS THR
SEQRES  10 E  444  LEU THR SER SER ALA HIS VAL THR SER TRP TRP PRO THR
SEQRES  11 E  444  LEU PHE GLY GLN GLY ARG ALA PHE ASP THR SER ARG TYR
SEQRES  12 E  444  PHE ILE ILE CYS LEU ASN TYR LEU GLY SER PRO PHE GLY
SEQRES  13 E  444  SER ALA GLY PRO CYS SER PRO ASP PRO ASP ALA GLU GLY
SEQRES  14 E  444  GLN ARG PRO TYR GLY ALA LYS PHE PRO ARG THR THR ILE
SEQRES  15 E  444  ARG ASP ASP VAL ARG ILE HIS ARG GLN VAL LEU ASP ARG
SEQRES  16 E  444  LEU GLY VAL ARG GLN ILE ALA ALA VAL VAL GLY ALA SER
SEQRES  17 E  444  MET GLY GLY MET HIS THR LEU GLU TRP ALA PHE PHE GLY
SEQRES  18 E  444  PRO GLU TYR VAL ARG LYS ILE VAL PRO ILE ALA THR SER
SEQRES  19 E  444  CYS ARG GLN SER GLY TRP CYS ALA ALA TRP PHE GLU THR
SEQRES  20 E  444  GLN ARG GLN CYS ILE TYR ASP ASP PRO LYS TYR LEU ASP
SEQRES  21 E  444  GLY GLU TYR ASP VAL ASP ASP GLN PRO VAL ARG GLY LEU
SEQRES  22 E  444  GLU THR ALA ARG LYS ILE ALA ASN LEU THR TYR LYS SER
SEQRES  23 E  444  LYS PRO ALA MET ASP GLU ARG PHE HIS MET ALA PRO GLY
SEQRES  24 E  444  VAL GLN ALA GLY ARG ASN ILE SER SER GLN ASP ALA LYS
SEQRES  25 E  444  LYS GLU ILE ASN GLY THR ASP SER GLY ASN SER HIS ARG
SEQRES  26 E  444  ALA GLY GLN PRO ILE GLU ALA VAL SER SER TYR LEU ARG
SEQRES  27 E  444  TYR GLN ALA GLN LYS PHE ALA ALA SER PHE ASP ALA ASN
SEQRES  28 E  444  CYS TYR ILE ALA MET THR LEU LYS PHE ASP THR HIS ASP
SEQRES  29 E  444  ILE SER ARG GLY ARG ALA GLY SER ILE PRO GLU ALA LEU
SEQRES  30 E  444  ALA MET ILE THR GLN PRO ALA LEU ILE ILE CYS ALA ARG
SEQRES  31 E  444  SER ASP GLY LEU TYR SER PHE ASP GLU HIS VAL GLU MET
SEQRES  32 E  444  GLY ARG SER ILE PRO ASN SER ARG LEU CYS VAL VAL ASP
SEQRES  33 E  444  THR ASN GLU GLY HIS ASP PHE PHE VAL MET GLU ALA ASP
SEQRES  34 E  444  LYS VAL ASN ASP ALA VAL ARG GLY PHE LEU ASP GLN SER
SEQRES  35 E  444  LEU MET
SEQRES   1 F  444  MET LEU PRO SER ALA GLN VAL ALA ARG LEU LYS PRO ASP
SEQRES   2 F  444  PRO PHE PRO PRO SER LEU SER PRO ILE PRO HIS GLY ALA
SEQRES   3 F  444  VAL THR PHE ALA ALA LEU ALA PRO CYS HIS ASN LEU PRO
SEQRES   4 F  444  ILE PHE SER SER ARG GLN MET LEU ARG ASP SER LEU THR
SEQRES   5 F  444  TYR SER HIS THR SER PRO THR MET SER PRO GLN ILE ALA
SEQRES   6 F  444  ASN ARG PHE GLU ALA SER LEU ASP ALA GLN ASP ILE ALA
SEQRES   7 F  444  ARG ILE SER LEU PHE THR LEU GLU SER GLY VAL ILE LEU
SEQRES   8 F  444  ARG ASP VAL PRO VAL ALA TYR LYS SER TRP GLY ARG MET
SEQRES   9 F  444  ASN VAL SER ARG ASP ASN CYS VAL ILE VAL CYS HIS THR
SEQRES  10 F  444  LEU THR SER SER ALA HIS VAL THR SER TRP TRP PRO THR
SEQRES  11 F  444  LEU PHE GLY GLN GLY ARG ALA PHE ASP THR SER ARG TYR
SEQRES  12 F  444  PHE ILE ILE CYS LEU ASN TYR LEU GLY SER PRO PHE GLY
SEQRES  13 F  444  SER ALA GLY PRO CYS SER PRO ASP PRO ASP ALA GLU GLY
SEQRES  14 F  444  GLN ARG PRO TYR GLY ALA LYS PHE PRO ARG THR THR ILE
SEQRES  15 F  444  ARG ASP ASP VAL ARG ILE HIS ARG GLN VAL LEU ASP ARG
SEQRES  16 F  444  LEU GLY VAL ARG GLN ILE ALA ALA VAL VAL GLY ALA SER
SEQRES  17 F  444  MET GLY GLY MET HIS THR LEU GLU TRP ALA PHE PHE GLY
SEQRES  18 F  444  PRO GLU TYR VAL ARG LYS ILE VAL PRO ILE ALA THR SER
SEQRES  19 F  444  CYS ARG GLN SER GLY TRP CYS ALA ALA TRP PHE GLU THR
SEQRES  20 F  444  GLN ARG GLN CYS ILE TYR ASP ASP PRO LYS TYR LEU ASP
SEQRES  21 F  444  GLY GLU TYR ASP VAL ASP ASP GLN PRO VAL ARG GLY LEU
SEQRES  22 F  444  GLU THR ALA ARG LYS ILE ALA ASN LEU THR TYR LYS SER
SEQRES  23 F  444  LYS PRO ALA MET ASP GLU ARG PHE HIS MET ALA PRO GLY
SEQRES  24 F  444  VAL GLN ALA GLY ARG ASN ILE SER SER GLN ASP ALA LYS
SEQRES  25 F  444  LYS GLU ILE ASN GLY THR ASP SER GLY ASN SER HIS ARG
SEQRES  26 F  444  ALA GLY GLN PRO ILE GLU ALA VAL SER SER TYR LEU ARG
SEQRES  27 F  444  TYR GLN ALA GLN LYS PHE ALA ALA SER PHE ASP ALA ASN
SEQRES  28 F  444  CYS TYR ILE ALA MET THR LEU LYS PHE ASP THR HIS ASP
SEQRES  29 F  444  ILE SER ARG GLY ARG ALA GLY SER ILE PRO GLU ALA LEU
SEQRES  30 F  444  ALA MET ILE THR GLN PRO ALA LEU ILE ILE CYS ALA ARG
SEQRES  31 F  444  SER ASP GLY LEU TYR SER PHE ASP GLU HIS VAL GLU MET
SEQRES  32 F  444  GLY ARG SER ILE PRO ASN SER ARG LEU CYS VAL VAL ASP
SEQRES  33 F  444  THR ASN GLU GLY HIS ASP PHE PHE VAL MET GLU ALA ASP
SEQRES  34 F  444  LYS VAL ASN ASP ALA VAL ARG GLY PHE LEU ASP GLN SER
SEQRES  35 F  444  LEU MET
SEQRES   1 G  444  MET LEU PRO SER ALA GLN VAL ALA ARG LEU LYS PRO ASP
SEQRES   2 G  444  PRO PHE PRO PRO SER LEU SER PRO ILE PRO HIS GLY ALA
SEQRES   3 G  444  VAL THR PHE ALA ALA LEU ALA PRO CYS HIS ASN LEU PRO
SEQRES   4 G  444  ILE PHE SER SER ARG GLN MET LEU ARG ASP SER LEU THR
SEQRES   5 G  444  TYR SER HIS THR SER PRO THR MET SER PRO GLN ILE ALA
SEQRES   6 G  444  ASN ARG PHE GLU ALA SER LEU ASP ALA GLN ASP ILE ALA
SEQRES   7 G  444  ARG ILE SER LEU PHE THR LEU GLU SER GLY VAL ILE LEU
SEQRES   8 G  444  ARG ASP VAL PRO VAL ALA TYR LYS SER TRP GLY ARG MET
SEQRES   9 G  444  ASN VAL SER ARG ASP ASN CYS VAL ILE VAL CYS HIS THR
SEQRES  10 G  444  LEU THR SER SER ALA HIS VAL THR SER TRP TRP PRO THR
SEQRES  11 G  444  LEU PHE GLY GLN GLY ARG ALA PHE ASP THR SER ARG TYR
SEQRES  12 G  444  PHE ILE ILE CYS LEU ASN TYR LEU GLY SER PRO PHE GLY
SEQRES  13 G  444  SER ALA GLY PRO CYS SER PRO ASP PRO ASP ALA GLU GLY
SEQRES  14 G  444  GLN ARG PRO TYR GLY ALA LYS PHE PRO ARG THR THR ILE
SEQRES  15 G  444  ARG ASP ASP VAL ARG ILE HIS ARG GLN VAL LEU ASP ARG
SEQRES  16 G  444  LEU GLY VAL ARG GLN ILE ALA ALA VAL VAL GLY ALA SER
SEQRES  17 G  444  MET GLY GLY MET HIS THR LEU GLU TRP ALA PHE PHE GLY
SEQRES  18 G  444  PRO GLU TYR VAL ARG LYS ILE VAL PRO ILE ALA THR SER
SEQRES  19 G  444  CYS ARG GLN SER GLY TRP CYS ALA ALA TRP PHE GLU THR
SEQRES  20 G  444  GLN ARG GLN CYS ILE TYR ASP ASP PRO LYS TYR LEU ASP
SEQRES  21 G  444  GLY GLU TYR ASP VAL ASP ASP GLN PRO VAL ARG GLY LEU
SEQRES  22 G  444  GLU THR ALA ARG LYS ILE ALA ASN LEU THR TYR LYS SER
SEQRES  23 G  444  LYS PRO ALA MET ASP GLU ARG PHE HIS MET ALA PRO GLY
SEQRES  24 G  444  VAL GLN ALA GLY ARG ASN ILE SER SER GLN ASP ALA LYS
SEQRES  25 G  444  LYS GLU ILE ASN GLY THR ASP SER GLY ASN SER HIS ARG
SEQRES  26 G  444  ALA GLY GLN PRO ILE GLU ALA VAL SER SER TYR LEU ARG
SEQRES  27 G  444  TYR GLN ALA GLN LYS PHE ALA ALA SER PHE ASP ALA ASN
SEQRES  28 G  444  CYS TYR ILE ALA MET THR LEU LYS PHE ASP THR HIS ASP
SEQRES  29 G  444  ILE SER ARG GLY ARG ALA GLY SER ILE PRO GLU ALA LEU
SEQRES  30 G  444  ALA MET ILE THR GLN PRO ALA LEU ILE ILE CYS ALA ARG
SEQRES  31 G  444  SER ASP GLY LEU TYR SER PHE ASP GLU HIS VAL GLU MET
SEQRES  32 G  444  GLY ARG SER ILE PRO ASN SER ARG LEU CYS VAL VAL ASP
SEQRES  33 G  444  THR ASN GLU GLY HIS ASP PHE PHE VAL MET GLU ALA ASP
SEQRES  34 G  444  LYS VAL ASN ASP ALA VAL ARG GLY PHE LEU ASP GLN SER
SEQRES  35 G  444  LEU MET
SEQRES   1 H  444  MET LEU PRO SER ALA GLN VAL ALA ARG LEU LYS PRO ASP
SEQRES   2 H  444  PRO PHE PRO PRO SER LEU SER PRO ILE PRO HIS GLY ALA
SEQRES   3 H  444  VAL THR PHE ALA ALA LEU ALA PRO CYS HIS ASN LEU PRO
SEQRES   4 H  444  ILE PHE SER SER ARG GLN MET LEU ARG ASP SER LEU THR
SEQRES   5 H  444  TYR SER HIS THR SER PRO THR MET SER PRO GLN ILE ALA
SEQRES   6 H  444  ASN ARG PHE GLU ALA SER LEU ASP ALA GLN ASP ILE ALA
SEQRES   7 H  444  ARG ILE SER LEU PHE THR LEU GLU SER GLY VAL ILE LEU
SEQRES   8 H  444  ARG ASP VAL PRO VAL ALA TYR LYS SER TRP GLY ARG MET
SEQRES   9 H  444  ASN VAL SER ARG ASP ASN CYS VAL ILE VAL CYS HIS THR
SEQRES  10 H  444  LEU THR SER SER ALA HIS VAL THR SER TRP TRP PRO THR
SEQRES  11 H  444  LEU PHE GLY GLN GLY ARG ALA PHE ASP THR SER ARG TYR
SEQRES  12 H  444  PHE ILE ILE CYS LEU ASN TYR LEU GLY SER PRO PHE GLY
SEQRES  13 H  444  SER ALA GLY PRO CYS SER PRO ASP PRO ASP ALA GLU GLY
SEQRES  14 H  444  GLN ARG PRO TYR GLY ALA LYS PHE PRO ARG THR THR ILE
SEQRES  15 H  444  ARG ASP ASP VAL ARG ILE HIS ARG GLN VAL LEU ASP ARG
SEQRES  16 H  444  LEU GLY VAL ARG GLN ILE ALA ALA VAL VAL GLY ALA SER
SEQRES  17 H  444  MET GLY GLY MET HIS THR LEU GLU TRP ALA PHE PHE GLY
SEQRES  18 H  444  PRO GLU TYR VAL ARG LYS ILE VAL PRO ILE ALA THR SER
SEQRES  19 H  444  CYS ARG GLN SER GLY TRP CYS ALA ALA TRP PHE GLU THR
SEQRES  20 H  444  GLN ARG GLN CYS ILE TYR ASP ASP PRO LYS TYR LEU ASP
SEQRES  21 H  444  GLY GLU TYR ASP VAL ASP ASP GLN PRO VAL ARG GLY LEU
SEQRES  22 H  444  GLU THR ALA ARG LYS ILE ALA ASN LEU THR TYR LYS SER
SEQRES  23 H  444  LYS PRO ALA MET ASP GLU ARG PHE HIS MET ALA PRO GLY
SEQRES  24 H  444  VAL GLN ALA GLY ARG ASN ILE SER SER GLN ASP ALA LYS
SEQRES  25 H  444  LYS GLU ILE ASN GLY THR ASP SER GLY ASN SER HIS ARG
SEQRES  26 H  444  ALA GLY GLN PRO ILE GLU ALA VAL SER SER TYR LEU ARG
SEQRES  27 H  444  TYR GLN ALA GLN LYS PHE ALA ALA SER PHE ASP ALA ASN
SEQRES  28 H  444  CYS TYR ILE ALA MET THR LEU LYS PHE ASP THR HIS ASP
SEQRES  29 H  444  ILE SER ARG GLY ARG ALA GLY SER ILE PRO GLU ALA LEU
SEQRES  30 H  444  ALA MET ILE THR GLN PRO ALA LEU ILE ILE CYS ALA ARG
SEQRES  31 H  444  SER ASP GLY LEU TYR SER PHE ASP GLU HIS VAL GLU MET
SEQRES  32 H  444  GLY ARG SER ILE PRO ASN SER ARG LEU CYS VAL VAL ASP
SEQRES  33 H  444  THR ASN GLU GLY HIS ASP PHE PHE VAL MET GLU ALA ASP
SEQRES  34 H  444  LYS VAL ASN ASP ALA VAL ARG GLY PHE LEU ASP GLN SER
SEQRES  35 H  444  LEU MET
SEQRES   1 I  444  MET LEU PRO SER ALA GLN VAL ALA ARG LEU LYS PRO ASP
SEQRES   2 I  444  PRO PHE PRO PRO SER LEU SER PRO ILE PRO HIS GLY ALA
SEQRES   3 I  444  VAL THR PHE ALA ALA LEU ALA PRO CYS HIS ASN LEU PRO
SEQRES   4 I  444  ILE PHE SER SER ARG GLN MET LEU ARG ASP SER LEU THR
SEQRES   5 I  444  TYR SER HIS THR SER PRO THR MET SER PRO GLN ILE ALA
SEQRES   6 I  444  ASN ARG PHE GLU ALA SER LEU ASP ALA GLN ASP ILE ALA
SEQRES   7 I  444  ARG ILE SER LEU PHE THR LEU GLU SER GLY VAL ILE LEU
SEQRES   8 I  444  ARG ASP VAL PRO VAL ALA TYR LYS SER TRP GLY ARG MET
SEQRES   9 I  444  ASN VAL SER ARG ASP ASN CYS VAL ILE VAL CYS HIS THR
SEQRES  10 I  444  LEU THR SER SER ALA HIS VAL THR SER TRP TRP PRO THR
SEQRES  11 I  444  LEU PHE GLY GLN GLY ARG ALA PHE ASP THR SER ARG TYR
SEQRES  12 I  444  PHE ILE ILE CYS LEU ASN TYR LEU GLY SER PRO PHE GLY
SEQRES  13 I  444  SER ALA GLY PRO CYS SER PRO ASP PRO ASP ALA GLU GLY
SEQRES  14 I  444  GLN ARG PRO TYR GLY ALA LYS PHE PRO ARG THR THR ILE
SEQRES  15 I  444  ARG ASP ASP VAL ARG ILE HIS ARG GLN VAL LEU ASP ARG
SEQRES  16 I  444  LEU GLY VAL ARG GLN ILE ALA ALA VAL VAL GLY ALA SER
SEQRES  17 I  444  MET GLY GLY MET HIS THR LEU GLU TRP ALA PHE PHE GLY
SEQRES  18 I  444  PRO GLU TYR VAL ARG LYS ILE VAL PRO ILE ALA THR SER
SEQRES  19 I  444  CYS ARG GLN SER GLY TRP CYS ALA ALA TRP PHE GLU THR
SEQRES  20 I  444  GLN ARG GLN CYS ILE TYR ASP ASP PRO LYS TYR LEU ASP
SEQRES  21 I  444  GLY GLU TYR ASP VAL ASP ASP GLN PRO VAL ARG GLY LEU
SEQRES  22 I  444  GLU THR ALA ARG LYS ILE ALA ASN LEU THR TYR LYS SER
SEQRES  23 I  444  LYS PRO ALA MET ASP GLU ARG PHE HIS MET ALA PRO GLY
SEQRES  24 I  444  VAL GLN ALA GLY ARG ASN ILE SER SER GLN ASP ALA LYS
SEQRES  25 I  444  LYS GLU ILE ASN GLY THR ASP SER GLY ASN SER HIS ARG
SEQRES  26 I  444  ALA GLY GLN PRO ILE GLU ALA VAL SER SER TYR LEU ARG
SEQRES  27 I  444  TYR GLN ALA GLN LYS PHE ALA ALA SER PHE ASP ALA ASN
SEQRES  28 I  444  CYS TYR ILE ALA MET THR LEU LYS PHE ASP THR HIS ASP
SEQRES  29 I  444  ILE SER ARG GLY ARG ALA GLY SER ILE PRO GLU ALA LEU
SEQRES  30 I  444  ALA MET ILE THR GLN PRO ALA LEU ILE ILE CYS ALA ARG
SEQRES  31 I  444  SER ASP GLY LEU TYR SER PHE ASP GLU HIS VAL GLU MET
SEQRES  32 I  444  GLY ARG SER ILE PRO ASN SER ARG LEU CYS VAL VAL ASP
SEQRES  33 I  444  THR ASN GLU GLY HIS ASP PHE PHE VAL MET GLU ALA ASP
SEQRES  34 I  444  LYS VAL ASN ASP ALA VAL ARG GLY PHE LEU ASP GLN SER
SEQRES  35 I  444  LEU MET
SEQRES   1 J  444  MET LEU PRO SER ALA GLN VAL ALA ARG LEU LYS PRO ASP
SEQRES   2 J  444  PRO PHE PRO PRO SER LEU SER PRO ILE PRO HIS GLY ALA
SEQRES   3 J  444  VAL THR PHE ALA ALA LEU ALA PRO CYS HIS ASN LEU PRO
SEQRES   4 J  444  ILE PHE SER SER ARG GLN MET LEU ARG ASP SER LEU THR
SEQRES   5 J  444  TYR SER HIS THR SER PRO THR MET SER PRO GLN ILE ALA
SEQRES   6 J  444  ASN ARG PHE GLU ALA SER LEU ASP ALA GLN ASP ILE ALA
SEQRES   7 J  444  ARG ILE SER LEU PHE THR LEU GLU SER GLY VAL ILE LEU
SEQRES   8 J  444  ARG ASP VAL PRO VAL ALA TYR LYS SER TRP GLY ARG MET
SEQRES   9 J  444  ASN VAL SER ARG ASP ASN CYS VAL ILE VAL CYS HIS THR
SEQRES  10 J  444  LEU THR SER SER ALA HIS VAL THR SER TRP TRP PRO THR
SEQRES  11 J  444  LEU PHE GLY GLN GLY ARG ALA PHE ASP THR SER ARG TYR
SEQRES  12 J  444  PHE ILE ILE CYS LEU ASN TYR LEU GLY SER PRO PHE GLY
SEQRES  13 J  444  SER ALA GLY PRO CYS SER PRO ASP PRO ASP ALA GLU GLY
SEQRES  14 J  444  GLN ARG PRO TYR GLY ALA LYS PHE PRO ARG THR THR ILE
SEQRES  15 J  444  ARG ASP ASP VAL ARG ILE HIS ARG GLN VAL LEU ASP ARG
SEQRES  16 J  444  LEU GLY VAL ARG GLN ILE ALA ALA VAL VAL GLY ALA SER
SEQRES  17 J  444  MET GLY GLY MET HIS THR LEU GLU TRP ALA PHE PHE GLY
SEQRES  18 J  444  PRO GLU TYR VAL ARG LYS ILE VAL PRO ILE ALA THR SER
SEQRES  19 J  444  CYS ARG GLN SER GLY TRP CYS ALA ALA TRP PHE GLU THR
SEQRES  20 J  444  GLN ARG GLN CYS ILE TYR ASP ASP PRO LYS TYR LEU ASP
SEQRES  21 J  444  GLY GLU TYR ASP VAL ASP ASP GLN PRO VAL ARG GLY LEU
SEQRES  22 J  444  GLU THR ALA ARG LYS ILE ALA ASN LEU THR TYR LYS SER
SEQRES  23 J  444  LYS PRO ALA MET ASP GLU ARG PHE HIS MET ALA PRO GLY
SEQRES  24 J  444  VAL GLN ALA GLY ARG ASN ILE SER SER GLN ASP ALA LYS
SEQRES  25 J  444  LYS GLU ILE ASN GLY THR ASP SER GLY ASN SER HIS ARG
SEQRES  26 J  444  ALA GLY GLN PRO ILE GLU ALA VAL SER SER TYR LEU ARG
SEQRES  27 J  444  TYR GLN ALA GLN LYS PHE ALA ALA SER PHE ASP ALA ASN
SEQRES  28 J  444  CYS TYR ILE ALA MET THR LEU LYS PHE ASP THR HIS ASP
SEQRES  29 J  444  ILE SER ARG GLY ARG ALA GLY SER ILE PRO GLU ALA LEU
SEQRES  30 J  444  ALA MET ILE THR GLN PRO ALA LEU ILE ILE CYS ALA ARG
SEQRES  31 J  444  SER ASP GLY LEU TYR SER PHE ASP GLU HIS VAL GLU MET
SEQRES  32 J  444  GLY ARG SER ILE PRO ASN SER ARG LEU CYS VAL VAL ASP
SEQRES  33 J  444  THR ASN GLU GLY HIS ASP PHE PHE VAL MET GLU ALA ASP
SEQRES  34 J  444  LYS VAL ASN ASP ALA VAL ARG GLY PHE LEU ASP GLN SER
SEQRES  35 J  444  LEU MET
SEQRES   1 K  444  MET LEU PRO SER ALA GLN VAL ALA ARG LEU LYS PRO ASP
SEQRES   2 K  444  PRO PHE PRO PRO SER LEU SER PRO ILE PRO HIS GLY ALA
SEQRES   3 K  444  VAL THR PHE ALA ALA LEU ALA PRO CYS HIS ASN LEU PRO
SEQRES   4 K  444  ILE PHE SER SER ARG GLN MET LEU ARG ASP SER LEU THR
SEQRES   5 K  444  TYR SER HIS THR SER PRO THR MET SER PRO GLN ILE ALA
SEQRES   6 K  444  ASN ARG PHE GLU ALA SER LEU ASP ALA GLN ASP ILE ALA
SEQRES   7 K  444  ARG ILE SER LEU PHE THR LEU GLU SER GLY VAL ILE LEU
SEQRES   8 K  444  ARG ASP VAL PRO VAL ALA TYR LYS SER TRP GLY ARG MET
SEQRES   9 K  444  ASN VAL SER ARG ASP ASN CYS VAL ILE VAL CYS HIS THR
SEQRES  10 K  444  LEU THR SER SER ALA HIS VAL THR SER TRP TRP PRO THR
SEQRES  11 K  444  LEU PHE GLY GLN GLY ARG ALA PHE ASP THR SER ARG TYR
SEQRES  12 K  444  PHE ILE ILE CYS LEU ASN TYR LEU GLY SER PRO PHE GLY
SEQRES  13 K  444  SER ALA GLY PRO CYS SER PRO ASP PRO ASP ALA GLU GLY
SEQRES  14 K  444  GLN ARG PRO TYR GLY ALA LYS PHE PRO ARG THR THR ILE
SEQRES  15 K  444  ARG ASP ASP VAL ARG ILE HIS ARG GLN VAL LEU ASP ARG
SEQRES  16 K  444  LEU GLY VAL ARG GLN ILE ALA ALA VAL VAL GLY ALA SER
SEQRES  17 K  444  MET GLY GLY MET HIS THR LEU GLU TRP ALA PHE PHE GLY
SEQRES  18 K  444  PRO GLU TYR VAL ARG LYS ILE VAL PRO ILE ALA THR SER
SEQRES  19 K  444  CYS ARG GLN SER GLY TRP CYS ALA ALA TRP PHE GLU THR
SEQRES  20 K  444  GLN ARG GLN CYS ILE TYR ASP ASP PRO LYS TYR LEU ASP
SEQRES  21 K  444  GLY GLU TYR ASP VAL ASP ASP GLN PRO VAL ARG GLY LEU
SEQRES  22 K  444  GLU THR ALA ARG LYS ILE ALA ASN LEU THR TYR LYS SER
SEQRES  23 K  444  LYS PRO ALA MET ASP GLU ARG PHE HIS MET ALA PRO GLY
SEQRES  24 K  444  VAL GLN ALA GLY ARG ASN ILE SER SER GLN ASP ALA LYS
SEQRES  25 K  444  LYS GLU ILE ASN GLY THR ASP SER GLY ASN SER HIS ARG
SEQRES  26 K  444  ALA GLY GLN PRO ILE GLU ALA VAL SER SER TYR LEU ARG
SEQRES  27 K  444  TYR GLN ALA GLN LYS PHE ALA ALA SER PHE ASP ALA ASN
SEQRES  28 K  444  CYS TYR ILE ALA MET THR LEU LYS PHE ASP THR HIS ASP
SEQRES  29 K  444  ILE SER ARG GLY ARG ALA GLY SER ILE PRO GLU ALA LEU
SEQRES  30 K  444  ALA MET ILE THR GLN PRO ALA LEU ILE ILE CYS ALA ARG
SEQRES  31 K  444  SER ASP GLY LEU TYR SER PHE ASP GLU HIS VAL GLU MET
SEQRES  32 K  444  GLY ARG SER ILE PRO ASN SER ARG LEU CYS VAL VAL ASP
SEQRES  33 K  444  THR ASN GLU GLY HIS ASP PHE PHE VAL MET GLU ALA ASP
SEQRES  34 K  444  LYS VAL ASN ASP ALA VAL ARG GLY PHE LEU ASP GLN SER
SEQRES  35 K  444  LEU MET
SEQRES   1 L  444  MET LEU PRO SER ALA GLN VAL ALA ARG LEU LYS PRO ASP
SEQRES   2 L  444  PRO PHE PRO PRO SER LEU SER PRO ILE PRO HIS GLY ALA
SEQRES   3 L  444  VAL THR PHE ALA ALA LEU ALA PRO CYS HIS ASN LEU PRO
SEQRES   4 L  444  ILE PHE SER SER ARG GLN MET LEU ARG ASP SER LEU THR
SEQRES   5 L  444  TYR SER HIS THR SER PRO THR MET SER PRO GLN ILE ALA
SEQRES   6 L  444  ASN ARG PHE GLU ALA SER LEU ASP ALA GLN ASP ILE ALA
SEQRES   7 L  444  ARG ILE SER LEU PHE THR LEU GLU SER GLY VAL ILE LEU
SEQRES   8 L  444  ARG ASP VAL PRO VAL ALA TYR LYS SER TRP GLY ARG MET
SEQRES   9 L  444  ASN VAL SER ARG ASP ASN CYS VAL ILE VAL CYS HIS THR
SEQRES  10 L  444  LEU THR SER SER ALA HIS VAL THR SER TRP TRP PRO THR
SEQRES  11 L  444  LEU PHE GLY GLN GLY ARG ALA PHE ASP THR SER ARG TYR
SEQRES  12 L  444  PHE ILE ILE CYS LEU ASN TYR LEU GLY SER PRO PHE GLY
SEQRES  13 L  444  SER ALA GLY PRO CYS SER PRO ASP PRO ASP ALA GLU GLY
SEQRES  14 L  444  GLN ARG PRO TYR GLY ALA LYS PHE PRO ARG THR THR ILE
SEQRES  15 L  444  ARG ASP ASP VAL ARG ILE HIS ARG GLN VAL LEU ASP ARG
SEQRES  16 L  444  LEU GLY VAL ARG GLN ILE ALA ALA VAL VAL GLY ALA SER
SEQRES  17 L  444  MET GLY GLY MET HIS THR LEU GLU TRP ALA PHE PHE GLY
SEQRES  18 L  444  PRO GLU TYR VAL ARG LYS ILE VAL PRO ILE ALA THR SER
SEQRES  19 L  444  CYS ARG GLN SER GLY TRP CYS ALA ALA TRP PHE GLU THR
SEQRES  20 L  444  GLN ARG GLN CYS ILE TYR ASP ASP PRO LYS TYR LEU ASP
SEQRES  21 L  444  GLY GLU TYR ASP VAL ASP ASP GLN PRO VAL ARG GLY LEU
SEQRES  22 L  444  GLU THR ALA ARG LYS ILE ALA ASN LEU THR TYR LYS SER
SEQRES  23 L  444  LYS PRO ALA MET ASP GLU ARG PHE HIS MET ALA PRO GLY
SEQRES  24 L  444  VAL GLN ALA GLY ARG ASN ILE SER SER GLN ASP ALA LYS
SEQRES  25 L  444  LYS GLU ILE ASN GLY THR ASP SER GLY ASN SER HIS ARG
SEQRES  26 L  444  ALA GLY GLN PRO ILE GLU ALA VAL SER SER TYR LEU ARG
SEQRES  27 L  444  TYR GLN ALA GLN LYS PHE ALA ALA SER PHE ASP ALA ASN
SEQRES  28 L  444  CYS TYR ILE ALA MET THR LEU LYS PHE ASP THR HIS ASP
SEQRES  29 L  444  ILE SER ARG GLY ARG ALA GLY SER ILE PRO GLU ALA LEU
SEQRES  30 L  444  ALA MET ILE THR GLN PRO ALA LEU ILE ILE CYS ALA ARG
SEQRES  31 L  444  SER ASP GLY LEU TYR SER PHE ASP GLU HIS VAL GLU MET
SEQRES  32 L  444  GLY ARG SER ILE PRO ASN SER ARG LEU CYS VAL VAL ASP
SEQRES  33 L  444  THR ASN GLU GLY HIS ASP PHE PHE VAL MET GLU ALA ASP
SEQRES  34 L  444  LYS VAL ASN ASP ALA VAL ARG GLY PHE LEU ASP GLN SER
SEQRES  35 L  444  LEU MET
HET    COA  A1383      48
HET    COA  B1383      48
HET    COA  C1383      48
HET    COA  D1383      48
HET    COA  E1383      48
HET    COA  F1383      48
HET    COA  G1383      48
HET    COA  H1383      48
HET    COA  I1383      48
HET    COA  J1385      48
HET    COA  K1385      48
HET    COA  L1383      48
HET    GOL  B1384       6
HET    GOL  I1384       6
HET    ACT  A1384       4
HET    ACT  B1385       4
HET    ACT  E1384       4
HET    ACT  I1385       4
HET    ACT  H1384       4
HET    ACT  G1384       4
HET    ACT  D1384       4
HET    ACT  C1384       4
HET    ACT  F1384       4
HET    ACT  J1386       4
HET    ACT  K1386       4
HET    ACT  L1384       4
HETNAM     COA COENZYME A
HETNAM     ACT ACETATE ION
HETNAM     GOL GLYCEROL
FORMUL  13  COA    12(C21 H36 N7 O16 P3 S)
FORMUL  14  ACT    12(C2 H3 O2 1-)
FORMUL  15  GOL    2(C3 H8 O3)
FORMUL  16  HOH   *1573(H2 O1)
HELIX    1   1 ASN A    7  SER A   12  1                                   6
HELIX    2   2 HIS A   64  TRP A   68  5                                   5
HELIX    3   3 TRP A   69  LEU A   72  5                                   4
HELIX    4   4 TYR A  114  PHE A  118  5                                   5
HELIX    5   5 THR A  122  GLY A  138  1                                  17
HELIX    6   6 SER A  149  ALA A  159  1                                  11
HELIX    7   7 PHE A  160  GLY A  162  5                                   3
HELIX    8   8 SER A  179  ASP A  196  1                                  18
HELIX    9   9 TYR A  199  GLU A  203  5                                   5
HELIX   10  10 PRO A  210  TYR A  225  1                                  16
HELIX   11  11 SER A  227  PHE A  235  1                                   9
HELIX   12  12 PRO A  270  GLU A  272  5                                   3
HELIX   13  13 ALA A  273  SER A  288  1                                  16
HELIX   14  14 ASP A  290  THR A  303  1                                  14
HELIX   15  15 SER A  313  ALA A  319  1                                   7
HELIX   16  16 SER A  337  ILE A  348  1                                  12
HELIX   17  17 GLU A  360  HIS A  362  5                                   3
HELIX   18  18 ASP A  363  GLU A  368  1                                   6
HELIX   19  19 GLU A  368  ASP A  381  1                                  14
HELIX   20  20 ASN B    7  SER B   12  1                                   6
HELIX   21  21 HIS B   64  TRP B   68  5                                   5
HELIX   22  22 TRP B   69  LEU B   72  5                                   4
HELIX   23  23 TYR B  114  PHE B  118  5                                   5
HELIX   24  24 THR B  122  GLY B  138  1                                  17
HELIX   25  25 SER B  149  ALA B  159  1                                  11
HELIX   26  26 PHE B  160  GLY B  162  5                                   3
HELIX   27  27 SER B  179  ASP B  195  1                                  17
HELIX   28  28 TYR B  199  GLU B  203  5                                   5
HELIX   29  29 PRO B  210  TYR B  225  1                                  16
HELIX   30  30 SER B  227  PHE B  235  1                                   9
HELIX   31  31 PRO B  270  GLU B  272  5                                   3
HELIX   32  32 ALA B  273  SER B  288  1                                  16
HELIX   33  33 ASP B  290  LYS B  300  1                                  11
HELIX   34  34 PHE B  301  HIS B  304  5                                   4
HELIX   35  35 SER B  313  MET B  320  1                                   8
HELIX   36  36 SER B  337  ILE B  348  1                                  12
HELIX   37  37 GLU B  360  HIS B  362  5                                   3
HELIX   38  38 ASP B  363  GLU B  368  1                                   6
HELIX   39  39 GLU B  368  ASP B  381  1                                  14
HELIX   40  40 ASN C    7  SER C   12  1                                   6
HELIX   41  41 HIS C   64  TRP C   68  5                                   5
HELIX   42  42 TRP C   69  LEU C   72  5                                   4
HELIX   43  43 ASP C  105  GLU C  109  5                                   5
HELIX   44  44 TYR C  114  PHE C  118  5                                   5
HELIX   45  45 THR C  122  GLY C  138  1                                  17
HELIX   46  46 SER C  149  ALA C  159  1                                  11
HELIX   47  47 PHE C  160  GLY C  162  5                                   3
HELIX   48  48 SER C  179  ASP C  196  1                                  18
HELIX   49  49 TYR C  199  GLU C  203  5                                   5
HELIX   50  50 PRO C  210  TYR C  225  1                                  16
HELIX   51  51 SER C  227  PHE C  235  1                                   9
HELIX   52  52 PRO C  270  GLU C  272  5                                   3
HELIX   53  53 ALA C  273  SER C  288  1                                  16
HELIX   54  54 ASP C  290  THR C  303  1                                  14
HELIX   55  55 SER C  313  MET C  320  1                                   8
HELIX   56  56 SER C  337  ILE C  348  1                                  12
HELIX   57  57 ASP C  363  GLU C  368  1                                   6
HELIX   58  58 GLU C  368  GLN C  382  1                                  15
HELIX   59  59 ASN D    7  SER D   12  1                                   6
HELIX   60  60 HIS D   64  TRP D   68  5                                   5
HELIX   61  61 TRP D   69  LEU D   72  5                                   4
HELIX   62  62 ASP D  105  GLU D  109  5                                   5
HELIX   63  63 TYR D  114  PHE D  118  5                                   5
HELIX   64  64 THR D  122  GLY D  138  1                                  17
HELIX   65  65 SER D  149  ALA D  159  1                                  11
HELIX   66  66 PHE D  160  GLY D  162  5                                   3
HELIX   67  67 SER D  179  ASP D  196  1                                  18
HELIX   68  68 TYR D  199  GLU D  203  5                                   5
HELIX   69  69 PRO D  210  TYR D  225  1                                  16
HELIX   70  70 SER D  227  PHE D  235  1                                   9
HELIX   71  71 PRO D  270  GLU D  272  5                                   3
HELIX   72  72 ALA D  273  ALA D  287  1                                  15
HELIX   73  73 ASP D  290  THR D  303  1                                  14
HELIX   74  74 SER D  313  MET D  320  1                                   8
HELIX   75  75 SER D  337  ILE D  348  1                                  12
HELIX   76  76 GLU D  360  HIS D  362  5                                   3
HELIX   77  77 ASP D  363  GLU D  368  1                                   6
HELIX   78  78 GLU D  368  ASP D  381  1                                  14
HELIX   79  79 ASN E    7  SER E   12  1                                   6
HELIX   80  80 HIS E   64  TRP E   68  5                                   5
HELIX   81  81 TRP E   69  LEU E   72  5                                   4
HELIX   82  82 TYR E  114  PHE E  118  5                                   5
HELIX   83  83 THR E  122  GLY E  138  1                                  17
HELIX   84  84 SER E  149  ALA E  159  1                                  11
HELIX   85  85 PHE E  160  GLY E  162  5                                   3
HELIX   86  86 SER E  179  ASP E  195  1                                  17
HELIX   87  87 TYR E  199  GLU E  203  5                                   5
HELIX   88  88 PRO E  210  TYR E  225  1                                  16
HELIX   89  89 SER E  227  PHE E  235  1                                   9
HELIX   90  90 PRO E  270  GLU E  272  5                                   3
HELIX   91  91 ALA E  273  SER E  288  1                                  16
HELIX   92  92 ASP E  290  THR E  303  1                                  14
HELIX   93  93 SER E  313  ALA E  319  1                                   7
HELIX   94  94 SER E  337  ILE E  348  1                                  12
HELIX   95  95 GLU E  360  HIS E  362  5                                   3
HELIX   96  96 ASP E  363  GLU E  368  1                                   6
HELIX   97  97 GLU E  368  ASP E  381  1                                  14
HELIX   98  98 ASN F    7  SER F   12  1                                   6
HELIX   99  99 HIS F   64  TRP F   68  5                                   5
HELIX  100 100 TRP F   69  LEU F   72  5                                   4
HELIX  101 101 TYR F  114  PHE F  118  5                                   5
HELIX  102 102 THR F  122  GLY F  138  1                                  17
HELIX  103 103 SER F  149  ALA F  159  1                                  11
HELIX  104 104 PHE F  160  GLY F  162  5                                   3
HELIX  105 105 SER F  179  ASP F  195  1                                  17
HELIX  106 106 TYR F  199  GLU F  203  5                                   5
HELIX  107 107 PRO F  210  TYR F  225  1                                  16
HELIX  108 108 SER F  227  PHE F  235  1                                   9
HELIX  109 109 PRO F  270  GLU F  272  5                                   3
HELIX  110 110 ALA F  273  SER F  288  1                                  16
HELIX  111 111 ASP F  290  ASP F  302  1                                  13
HELIX  112 112 SER F  313  MET F  320  1                                   8
HELIX  113 113 SER F  337  ILE F  348  1                                  12
HELIX  114 114 ASP F  363  GLU F  368  1                                   6
HELIX  115 115 GLU F  368  GLN F  382  1                                  15
HELIX  116 116 ASN G    7  SER G   12  1                                   6
HELIX  117 117 HIS G   64  TRP G   68  5                                   5
HELIX  118 118 TRP G   69  LEU G   72  5                                   4
HELIX  119 119 TYR G  114  PHE G  118  5                                   5
HELIX  120 120 THR G  122  LEU G  137  1                                  16
HELIX  121 121 SER G  149  ALA G  159  1                                  11
HELIX  122 122 PHE G  160  GLY G  162  5                                   3
HELIX  123 123 SER G  179  ASP G  196  1                                  18
HELIX  124 124 TYR G  199  GLU G  203  5                                   5
HELIX  125 125 PRO G  210  TYR G  225  1                                  16
HELIX  126 126 SER G  227  PHE G  235  1                                   9
HELIX  127 127 PRO G  270  GLU G  272  5                                   3
HELIX  128 128 ALA G  273  ALA G  287  1                                  15
HELIX  129 129 ASP G  290  LYS G  300  1                                  11
HELIX  130 130 PHE G  301  HIS G  304  5                                   4
HELIX  131 131 SER G  313  MET G  320  1                                   8
HELIX  132 132 SER G  337  ILE G  348  1                                  12
HELIX  133 133 ASP G  363  GLU G  368  1                                   6
HELIX  134 134 GLU G  368  GLN G  382  1                                  15
HELIX  135 135 ASN H    7  SER H   12  1                                   6
HELIX  136 136 HIS H   64  TRP H   68  5                                   5
HELIX  137 137 TRP H   69  LEU H   72  5                                   4
HELIX  138 138 TYR H  114  PHE H  118  5                                   5
HELIX  139 139 THR H  122  LEU H  137  1                                  16
HELIX  140 140 SER H  149  ALA H  159  1                                  11
HELIX  141 141 PHE H  160  GLY H  162  5                                   3
HELIX  142 142 SER H  179  ASP H  195  1                                  17
HELIX  143 143 TYR H  199  GLU H  203  5                                   5
HELIX  144 144 PRO H  210  TYR H  225  1                                  16
HELIX  145 145 SER H  227  PHE H  235  1                                   9
HELIX  146 146 PRO H  270  GLU H  272  5                                   3
HELIX  147 147 ALA H  273  SER H  288  1                                  16
HELIX  148 148 ASP H  290  LYS H  300  1                                  11
HELIX  149 149 PHE H  301  HIS H  304  5                                   4
HELIX  150 150 SER H  313  MET H  320  1                                   8
HELIX  151 151 SER H  337  ILE H  348  1                                  12
HELIX  152 152 ASP H  363  GLU H  368  1                                   6
HELIX  153 153 GLU H  368  GLN H  382  1                                  15
HELIX  154 154 ASN I    7  SER I   12  1                                   6
HELIX  155 155 HIS I   64  TRP I   68  5                                   5
HELIX  156 156 TRP I   69  LEU I   72  5                                   4
HELIX  157 157 TYR I  114  PHE I  118  5                                   5
HELIX  158 158 THR I  122  GLY I  138  1                                  17
HELIX  159 159 SER I  149  ALA I  159  1                                  11
HELIX  160 160 PHE I  160  GLY I  162  5                                   3
HELIX  161 161 SER I  179  ASP I  195  1                                  17
HELIX  162 162 TYR I  199  GLU I  203  5                                   5
HELIX  163 163 PRO I  210  TYR I  225  1                                  16
HELIX  164 164 SER I  227  PHE I  235  1                                   9
HELIX  165 165 PRO I  270  GLU I  272  5                                   3
HELIX  166 166 ALA I  273  SER I  288  1                                  16
HELIX  167 167 ASP I  290  LYS I  300  1                                  11
HELIX  168 168 PHE I  301  HIS I  304  5                                   4
HELIX  169 169 SER I  313  ALA I  319  1                                   7
HELIX  170 170 SER I  337  ILE I  348  1                                  12
HELIX  171 171 GLU I  360  HIS I  362  5                                   3
HELIX  172 172 ASP I  363  GLU I  368  1                                   6
HELIX  173 173 GLU I  368  ASP I  381  1                                  14
HELIX  174 174 ASN J    7  SER J   12  1                                   6
HELIX  175 175 HIS J   64  TRP J   68  5                                   5
HELIX  176 176 TRP J   69  LEU J   72  5                                   4
HELIX  177 177 TYR J  114  PHE J  118  5                                   5
HELIX  178 178 THR J  122  LEU J  137  1                                  16
HELIX  179 179 SER J  149  ALA J  159  1                                  11
HELIX  180 180 PHE J  160  GLY J  162  5                                   3
HELIX  181 181 SER J  179  ASP J  196  1                                  18
HELIX  182 182 PRO J  197  GLU J  203  5                                   7
HELIX  183 183 PRO J  210  TYR J  225  1                                  16
HELIX  184 184 SER J  227  PHE J  235  1                                   9
HELIX  185 185 ALA J  273  ALA J  287  1                                  15
HELIX  186 186 ASP J  290  ASP J  302  1                                  13
HELIX  187 187 SER J  313  MET J  320  1                                   8
HELIX  188 188 SER J  337  ILE J  348  1                                  12
HELIX  189 189 ASP J  363  GLU J  368  1                                   6
HELIX  190 190 GLU J  368  GLN J  382  1                                  15
HELIX  191 191 ASN K    7  SER K   12  1                                   6
HELIX  192 192 HIS K   64  TRP K   68  5                                   5
HELIX  193 193 TRP K   69  LEU K   72  5                                   4
HELIX  194 194 TYR K  114  PHE K  118  5                                   5
HELIX  195 195 THR K  122  LEU K  137  1                                  16
HELIX  196 196 SER K  149  ALA K  159  1                                  11
HELIX  197 197 PHE K  160  GLY K  162  5                                   3
HELIX  198 198 SER K  179  ASP K  196  1                                  18
HELIX  199 199 PRO K  197  GLU K  203  5                                   7
HELIX  200 200 PRO K  210  TYR K  225  1                                  16
HELIX  201 201 SER K  227  PHE K  235  1                                   9
HELIX  202 202 ALA K  273  ALA K  287  1                                  15
HELIX  203 203 ASP K  290  ASP K  302  1                                  13
HELIX  204 204 SER K  313  MET K  320  1                                   8
HELIX  205 205 SER K  337  ILE K  348  1                                  12
HELIX  206 206 ASP K  363  GLU K  368  1                                   6
HELIX  207 207 GLU K  368  ASP K  381  1                                  14
HELIX  208 208 ASN L    7  SER L   12  1                                   6
HELIX  209 209 HIS L   64  TRP L   68  5                                   5
HELIX  210 210 TRP L   69  LEU L   72  5                                   4
HELIX  211 211 TYR L  114  PHE L  118  5                                   5
HELIX  212 212 THR L  122  GLY L  138  1                                  17
HELIX  213 213 SER L  149  ALA L  159  1                                  11
HELIX  214 214 PHE L  160  GLY L  162  5                                   3
HELIX  215 215 SER L  179  ASP L  195  1                                  17
HELIX  216 216 ASP L  196  GLU L  203  5                                   8
HELIX  217 217 PRO L  210  TYR L  225  1                                  16
HELIX  218 218 SER L  227  PHE L  235  1                                   9
HELIX  219 219 PRO L  270  GLU L  272  5                                   3
HELIX  220 220 ALA L  273  SER L  288  1                                  16
HELIX  221 221 ASP L  290  ASP L  302  1                                  13
HELIX  222 222 SER L  313  ALA L  319  1                                   7
HELIX  223 223 SER L  337  ILE L  348  1                                  12
HELIX  224 224 ASP L  363  GLU L  368  1                                   6
HELIX  225 225 GLU L  368  GLN L  382  1                                  15
SHEET    1  AA 6 ASP A  17  THR A  25  0
SHEET    2  AA 6 ILE A  31  TRP A  42 -1  O  LEU A  32   N  PHE A  24
SHEET    3  AA 6 PHE A  85  LEU A  89 -1  O  ILE A  86   N  TRP A  42
SHEET    4  AA 6 CYS A  52  CYS A  56  1  O  VAL A  53   N  ILE A  87
SHEET    5  AA 6 ILE A 142  ALA A 148  1  N  ALA A 143   O  CYS A  52
SHEET    6  AA 6 ILE A 169  ILE A 172  1  O  VAL A 170   N  GLY A 147
SHEET    1  AB 3 ALA A 325  CYS A 329  0
SHEET    2  AB 3 SER A 351  VAL A 355  1  O  ARG A 352   N  ILE A 327
SHEET    3  AB 3 GLN K 382  SER K 383  1  O  SER K 383   N  VAL A 355
SHEET    1  BA 6 ASP B  17  THR B  25  0
SHEET    2  BA 6 ILE B  31  TRP B  42 -1  O  LEU B  32   N  PHE B  24
SHEET    3  BA 6 PHE B  85  LEU B  89 -1  O  ILE B  86   N  TRP B  42
SHEET    4  BA 6 CYS B  52  CYS B  56  1  O  VAL B  53   N  ILE B  87
SHEET    5  BA 6 ILE B 142  ALA B 148  1  N  ALA B 143   O  CYS B  52
SHEET    6  BA 6 ILE B 169  ILE B 172  1  O  VAL B 170   N  GLY B 147
SHEET    1  BB 2 ALA B 325  CYS B 329  0
SHEET    2  BB 2 SER B 351  VAL B 355  1  O  ARG B 352   N  ILE B 327
SHEET    1  CA 6 ASP C  17  THR C  25  0
SHEET    2  CA 6 ILE C  31  TRP C  42 -1  O  LEU C  32   N  PHE C  24
SHEET    3  CA 6 PHE C  85  LEU C  89 -1  O  ILE C  86   N  TRP C  42
SHEET    4  CA 6 CYS C  52  CYS C  56  1  O  VAL C  53   N  ILE C  87
SHEET    5  CA 6 ILE C 142  ALA C 148  1  N  ALA C 143   O  CYS C  52
SHEET    6  CA 6 ILE C 169  ILE C 172  1  O  VAL C 170   N  GLY C 147
SHEET    1  CB 2 ALA C 325  ALA C 330  0
SHEET    2  CB 2 SER C 351  VAL C 356  1  O  ARG C 352   N  ILE C 327
SHEET    1  DA 6 ASP D  17  THR D  25  0
SHEET    2  DA 6 ILE D  31  TRP D  42 -1  O  LEU D  32   N  PHE D  24
SHEET    3  DA 6 PHE D  85  LEU D  89 -1  O  ILE D  86   N  TRP D  42
SHEET    4  DA 6 CYS D  52  CYS D  56  1  O  VAL D  53   N  ILE D  87
SHEET    5  DA 6 ILE D 142  ALA D 148  1  N  ALA D 143   O  CYS D  52
SHEET    6  DA 6 ILE D 169  ILE D 172  1  O  VAL D 170   N  GLY D 147
SHEET    1  DB 2 ALA D 325  CYS D 329  0
SHEET    2  DB 2 SER D 351  VAL D 355  1  O  ARG D 352   N  ILE D 327
SHEET    1  EA 6 ASP E  17  THR E  25  0
SHEET    2  EA 6 ILE E  31  TRP E  42 -1  O  LEU E  32   N  PHE E  24
SHEET    3  EA 6 PHE E  85  LEU E  89 -1  O  ILE E  86   N  TRP E  42
SHEET    4  EA 6 CYS E  52  CYS E  56  1  O  VAL E  53   N  ILE E  87
SHEET    5  EA 6 ILE E 142  ALA E 148  1  N  ALA E 143   O  CYS E  52
SHEET    6  EA 6 ILE E 169  ILE E 172  1  O  VAL E 170   N  GLY E 147
SHEET    1  EB 2 ALA E 325  CYS E 329  0
SHEET    2  EB 2 SER E 351  VAL E 355  1  O  ARG E 352   N  ILE E 327
SHEET    1  FA 6 ASP F  17  THR F  25  0
SHEET    2  FA 6 ILE F  31  TRP F  42 -1  O  LEU F  32   N  PHE F  24
SHEET    3  FA 6 PHE F  85  LEU F  89 -1  O  ILE F  86   N  TRP F  42
SHEET    4  FA 6 CYS F  52  CYS F  56  1  O  VAL F  53   N  ILE F  87
SHEET    5  FA 6 ILE F 142  ALA F 148  1  N  ALA F 143   O  CYS F  52
SHEET    6  FA 6 ILE F 169  ILE F 172  1  O  VAL F 170   N  GLY F 147
SHEET    1  FB 2 ALA F 325  CYS F 329  0
SHEET    2  FB 2 SER F 351  VAL F 355  1  O  ARG F 352   N  ILE F 327
SHEET    1  GA 6 ASP G  17  THR G  25  0
SHEET    2  GA 6 ILE G  31  TRP G  42 -1  O  LEU G  32   N  PHE G  24
SHEET    3  GA 6 PHE G  85  LEU G  89 -1  O  ILE G  86   N  TRP G  42
SHEET    4  GA 6 CYS G  52  CYS G  56  1  O  VAL G  53   N  ILE G  87
SHEET    5  GA 6 ILE G 142  ALA G 148  1  N  ALA G 143   O  CYS G  52
SHEET    6  GA 6 ILE G 169  ILE G 172  1  O  VAL G 170   N  GLY G 147
SHEET    1  GB 2 ALA G 325  CYS G 329  0
SHEET    2  GB 2 SER G 351  VAL G 355  1  O  ARG G 352   N  ILE G 327
SHEET    1  HA 6 ASP H  17  THR H  25  0
SHEET    2  HA 6 ILE H  31  TRP H  42 -1  O  LEU H  32   N  PHE H  24
SHEET    3  HA 6 PHE H  85  LEU H  89 -1  O  ILE H  86   N  TRP H  42
SHEET    4  HA 6 CYS H  52  CYS H  56  1  O  VAL H  53   N  ILE H  87
SHEET    5  HA 6 ILE H 142  ALA H 148  1  N  ALA H 143   O  CYS H  52
SHEET    6  HA 6 ILE H 169  ILE H 172  1  O  VAL H 170   N  GLY H 147
SHEET    1  HB 2 ALA H 325  CYS H 329  0
SHEET    2  HB 2 SER H 351  VAL H 355  1  O  ARG H 352   N  ILE H 327
SHEET    1  IA 6 ASP I  17  THR I  25  0
SHEET    2  IA 6 ILE I  31  TRP I  42 -1  O  LEU I  32   N  PHE I  24
SHEET    3  IA 6 PHE I  85  LEU I  89 -1  O  ILE I  86   N  TRP I  42
SHEET    4  IA 6 CYS I  52  CYS I  56  1  O  VAL I  53   N  ILE I  87
SHEET    5  IA 6 ILE I 142  ALA I 148  1  N  ALA I 143   O  CYS I  52
SHEET    6  IA 6 ILE I 169  ILE I 172  1  O  VAL I 170   N  GLY I 147
SHEET    1  IB 2 ALA I 325  CYS I 329  0
SHEET    2  IB 2 SER I 351  VAL I 355  1  O  ARG I 352   N  ILE I 327
SHEET    1  JA 6 ASP J  17  THR J  25  0
SHEET    2  JA 6 ILE J  31  TRP J  42 -1  O  LEU J  32   N  PHE J  24
SHEET    3  JA 6 PHE J  85  LEU J  89 -1  O  ILE J  86   N  TRP J  42
SHEET    4  JA 6 CYS J  52  CYS J  56  1  O  VAL J  53   N  ILE J  87
SHEET    5  JA 6 ILE J 142  ALA J 148  1  N  ALA J 143   O  CYS J  52
SHEET    6  JA 6 ILE J 169  ILE J 172  1  O  VAL J 170   N  GLY J 147
SHEET    1  JB 2 ALA J 325  CYS J 329  0
SHEET    2  JB 2 SER J 351  VAL J 355  1  O  ARG J 352   N  ILE J 327
SHEET    1  KA 6 ASP K  17  THR K  25  0
SHEET    2  KA 6 ILE K  31  TRP K  42 -1  O  LEU K  32   N  PHE K  24
SHEET    3  KA 6 PHE K  85  LEU K  89 -1  O  ILE K  86   N  TRP K  42
SHEET    4  KA 6 CYS K  52  CYS K  56  1  O  VAL K  53   N  ILE K  87
SHEET    5  KA 6 ILE K 142  ALA K 148  1  N  ALA K 143   O  CYS K  52
SHEET    6  KA 6 ILE K 169  ILE K 172  1  O  VAL K 170   N  GLY K 147
SHEET    1  KB 2 ALA K 325  CYS K 329  0
SHEET    2  KB 2 SER K 351  VAL K 355  1  O  ARG K 352   N  ILE K 327
SHEET    1  LA 6 ASP L  17  THR L  25  0
SHEET    2  LA 6 ILE L  31  TRP L  42 -1  O  LEU L  32   N  PHE L  24
SHEET    3  LA 6 PHE L  85  LEU L  89 -1  O  ILE L  86   N  TRP L  42
SHEET    4  LA 6 CYS L  52  CYS L  56  1  O  VAL L  53   N  ILE L  87
SHEET    5  LA 6 ILE L 142  ALA L 148  1  N  ALA L 143   O  CYS L  52
SHEET    6  LA 6 ILE L 169  ILE L 172  1  O  VAL L 170   N  GLY L 147
SHEET    1  LB 2 ALA L 325  ALA L 330  0
SHEET    2  LB 2 SER L 351  VAL L 356  1  O  ARG L 352   N  ILE L 327
SITE     1 AC1 17 SER A 149  ARG A 218  TYR A 225  LYS A 226
SITE     2 AC1 17 ARG A 234  ALA A 273  SER A 276  TYR A 277
SITE     3 AC1 17 TYR A 280  GLN A 281  LYS A 284  ASP A 363
SITE     4 AC1 17 MET A 367  HOH A2096  HOH A2163  HOH A2164
SITE     5 AC1 17 HOH A2165
SITE     1 AC2 18 ARG B 218  TYR B 225  LYS B 226  ARG B 234
SITE     2 AC2 18 GLY B 268  ALA B 273  SER B 276  TYR B 277
SITE     3 AC2 18 TYR B 280  GLN B 281  LYS B 284  HIS B 362
SITE     4 AC2 18 ASP B 363  MET B 367  HOH B2168  HOH B2169
SITE     5 AC2 18 HOH B2170  HOH B2171
SITE     1 AC3 14 THR C  60  TYR C 225  LYS C 226  ARG C 234
SITE     2 AC3 14 ALA C 273  SER C 276  TYR C 277  TYR C 280
SITE     3 AC3 14 GLN C 281  LYS C 284  ASP C 363  PHE C 365
SITE     4 AC3 14 MET C 367  HOH C2136
SITE     1 AC4 14 THR D  60  ARG D 218  TYR D 225  LYS D 226
SITE     2 AC4 14 ARG D 234  ALA D 273  SER D 276  TYR D 277
SITE     3 AC4 14 TYR D 280  GLN D 281  LYS D 284  ASP D 363
SITE     4 AC4 14 MET D 367  HOH D2123
SITE     1 AC5 19 SER E 149  ARG E 218  TYR E 225  LYS E 226
SITE     2 AC5 19 ARG E 234  GLY E 268  ALA E 273  SER E 276
SITE     3 AC5 19 TYR E 277  TYR E 280  GLN E 281  LYS E 284
SITE     4 AC5 19 HIS E 362  ASP E 363  MET E 367  HOH E2161
SITE     5 AC5 19 HOH E2162  HOH E2163  HOH E2164
SITE     1 AC6 17 THR F  58  THR F  60  ARG F 218  TYR F 225
SITE     2 AC6 17 LYS F 226  ARG F 234  GLY F 268  ALA F 273
SITE     3 AC6 17 SER F 276  TYR F 277  TYR F 280  GLN F 281
SITE     4 AC6 17 LYS F 284  ASP F 363  MET F 367  HOH F2054
SITE     5 AC6 17 HOH F2102
SITE     1 AC7 13 TYR G 225  ALA G 273  SER G 276  TYR G 277
SITE     2 AC7 13 TYR G 280  GLN G 281  LYS G 284  ASP G 363
SITE     3 AC7 13 PHE G 365  MET G 367  HOH G2140  ASP J 135
SITE     4 AC7 13 ARG J 136
SITE     1 AC8 13 SER H 149  TYR H 225  ALA H 273  SER H 276
SITE     2 AC8 13 TYR H 277  TYR H 280  GLN H 281  LYS H 284
SITE     3 AC8 13 HIS H 362  ASP H 363  PHE H 365  MET H 367
SITE     4 AC8 13 HOH H2144
SITE     1 AC9 17 THR I  58  ARG I 218  TYR I 225  LYS I 226
SITE     2 AC9 17 ARG I 234  GLY I 268  ALA I 273  SER I 276
SITE     3 AC9 17 TYR I 277  TYR I 280  GLN I 281  LYS I 284
SITE     4 AC9 17 HIS I 362  ASP I 363  MET I 367  HOH I2162
SITE     5 AC9 17 HOH I2163
SITE     1 BC1 16 THR J  58  LEU J  59  THR J  60  ARG J 218
SITE     2 BC1 16 LYS J 226  ARG J 234  GLY J 268  SER J 276
SITE     3 BC1 16 TYR J 277  TYR J 280  GLN J 281  LYS J 284
SITE     4 BC1 16 HIS J 362  ASP J 363  PHE J 365  MET J 367
SITE     1 BC2 17 THR K  58  SER K 149  ARG K 218  TYR K 225
SITE     2 BC2 17 LYS K 226  ARG K 234  GLY K 268  ALA K 273
SITE     3 BC2 17 SER K 276  TYR K 277  TYR K 280  GLN K 281
SITE     4 BC2 17 LYS K 284  HIS K 362  ASP K 363  PHE K 365
SITE     5 BC2 17 MET K 367
SITE     1 BC3 16 THR L  58  THR L  60  ARG L 218  TYR L 225
SITE     2 BC3 16 LYS L 226  ARG L 234  GLY L 268  ALA L 273
SITE     3 BC3 16 SER L 276  TYR L 277  TYR L 280  GLN L 281
SITE     4 BC3 16 LYS L 284  ASP L 363  MET L 367  HOH L2104
SITE     1 BC4  3 TRP B 185  THR B 224  GLY B 334
SITE     1 BC5  4 HOH A2101  TRP I 185  THR I 224  GLY I 334
SITE     1 BC6  6 ARG A 124  GLU A 157  PHE A 161  ARG A 310
SITE     2 BC6  6 THR B  25  ILE B  31
SITE     1 BC7  5 THR A  25  ILE A  31  GLU B 157  PHE B 161
SITE     2 BC7  5 ARG B 310
SITE     1 BC8  6 ARG E 124  ARG E 128  GLU E 157  PHE E 161
SITE     2 BC8  6 THR I  25  ILE I  31
SITE     1 BC9  6 THR E  25  ILE E  31  ARG I 124  GLU I 157
SITE     2 BC9  6 PHE I 160  PHE I 161
SITE     1 CC1  2 ARG H 128  GLU H 157
SITE     1 CC2  3 ARG G 124  ARG G 128  GLU G 157
SITE     1 CC3  3 ARG D 128  GLU D 157  PHE D 161
SITE     1 CC4  3 ARG C 128  GLU C 157  PHE C 161
SITE     1 CC5  2 ARG F 128  GLU F 157
SITE     1 CC6  2 GLU J 157  PHE J 161
SITE     1 CC7  2 ARG K 128  GLU K 157
SITE     1 CC8  2 ARG L 128  GLU L 157
CRYST1  121.959  109.278  197.001  90.00  90.23  90.00 P 1 21 1     24
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.008199  0.000000  0.000033        0.00000
SCALE2      0.000000  0.009151  0.000000        0.00000
SCALE3      0.000000  0.000000  0.005076        0.00000
MTRIX1   1 -0.999800 -0.009359 -0.015010      152.40000    1
MTRIX2   1  0.009254 -0.999900  0.007044       21.19000    1
MTRIX3   1 -0.015070  0.006904  0.999900        1.12600    1
MTRIX1   2 -0.784400  0.113400 -0.609800      146.40000    1
MTRIX2   2  0.084500  0.993500  0.076100        0.03458    1
MTRIX3   2  0.614500  0.008163 -0.788900      -20.22000    1
MTRIX1   3  0.787400 -0.116000 -0.605400       58.80000    1
MTRIX2   3 -0.087180 -0.993200  0.076940      -24.09000    1
MTRIX3   3 -0.610200 -0.007808 -0.792200      169.20000    1
MTRIX1   4  1.000000  0.000224  0.001490       60.92000    1
MTRIX2   4  0.000226 -1.000000 -0.000907       22.17000    1
MTRIX3   4  0.001489  0.000907 -1.000000       98.46000    1
MTRIX1   5 -0.517400  0.487000  0.703700      109.60000    1
MTRIX2   5  0.343500  0.871300 -0.350400       -8.06400    1
MTRIX3   5 -0.783800  0.060450 -0.618100       56.55000    1
MTRIX1   6  0.537000  0.481000  0.693000       -9.02700    1
MTRIX2   6  0.364000 -0.873200  0.324100      -42.79000    1
MTRIX3   6  0.761000  0.078180 -0.644000       58.66000    1
MTRIX1   7  0.536300 -0.479600 -0.694500       37.05000    1
MTRIX2   7  0.363700  0.873900 -0.322600      -52.50000    1
MTRIX3   7  0.761600 -0.079620  0.643100      -49.85000    1
MTRIX1   8 -0.999900  0.010300  0.013020      211.70000    1
MTRIX2   8  0.010220  0.999900 -0.006346       -0.94620    1
MTRIX3   8 -0.013090 -0.006212 -0.999900      100.50000    1
MTRIX1   9 -0.769200 -0.126800 -0.626300      154.90000    1
MTRIX2   9 -0.093990  0.991900 -0.085340       65.11000    1
MTRIX3   9  0.632100 -0.006770 -0.774900       42.63000    1
MTRIX1  10 -0.776300  0.126900  0.617500      152.30000    1
MTRIX2  10 -0.094950 -0.991900  0.084410      -23.86000    1
MTRIX3  10  0.623200  0.006894  0.782100      -70.99000    1
MTRIX1  11 -0.518100 -0.488800 -0.701900      220.90000    1
MTRIX2  11  0.342000 -0.870600  0.353800      -44.32000    1
MTRIX3  11 -0.784000 -0.056770  0.618200       44.42000    1
TER    2745      GLN A 382
TER    5490      GLN B 382
TER    8236      GLN C 382
TER   10985      GLN D 382
TER   13730      GLN E 382
TER   16425      GLN F 382
TER   19159      GLN G 382
TER   21920      GLN H 382
TER   24660      GLN I 382
TER   27385      LEU J 384
TER   30118      LEU K 384
TER   32816      GLN L 382
MASTER     2205    0   26  225   97    0   72   3935013   12  636  420
END