longtext: 2WJ3-pdb

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HEADER    OXIDOREDUCTASE                          20-MAY-09   2WJ3
TITLE     CRYSTAL STRUCTURE OF THE COFACTOR-DEVOID 1-H-3-HYDROXY-4-
TITLE    2 OXOQUINALDINE 2,4-DIOXYGENASE (HOD) FROM ARTHROBACTER
TITLE    3 NITROGUAJACOLICUS RU61A
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: 1-H-3-HYDROXY-4-OXOQUINALDINE 2,4-DIOXYGENASE;
COMPND   3 CHAIN: A, B, C, D;
COMPND   4 EC: 1.13.11.48;
COMPND   5 ENGINEERED: YES;
COMPND   6 MUTATION: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: ARTHROBACTER NITROGUAJACOLICUS;
SOURCE   3 ORGANISM_TAXID: 211146;
SOURCE   4 STRAIN: RU61A;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE   7 EXPRESSION_SYSTEM_STRAIN: M15/PREP4;
SOURCE   8 EXPRESSION_SYSTEM_VECTOR: PQE30
KEYWDS    ALPHA/BETA HYDROLASE, OXIDOREDUCTASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    R.A.STEINER
REVDAT   1   26-JAN-10 2WJ3    0
JRNL        AUTH   R.A.STEINER,H.J.JANSSEN,P.ROVERSI,A.J.OAKLEY,
JRNL        AUTH 2 S.FETZNER
JRNL        TITL   STRUCTURAL BASIS FOR COFACTOR-INDEPENDENT
JRNL        TITL 2 DIOXYGENATION OF N-HETEROAROMATIC COMPOUNDS AT THE
JRNL        TITL 3 {ALPHA}/{BETA}-HYDROLASE FOLD.
JRNL        REF    PROC.NATL.ACAD.SCI.USA        V. 107   657 2010
JRNL        REFN                   ISSN 0027-8424
JRNL        PMID   20080731
JRNL        DOI    10.1073/PNAS.0909033107
REMARK   1
REMARK   1 REFERENCE 1
REMARK   1  AUTH   R.A.STEINER,U.FRERICHS-DEEKEN,S.FETZNER
REMARK   1  TITL   CRYSTALLIZATION AND PRELIMINARY X-RAY ANALYSIS OF
REMARK   1  TITL 2 1H-3-HYDROXY-4-OXOQUINALDINE 2,4-DIOXYGENASE FROM
REMARK   1  TITL 3 ARTHROBACTER NITROGUAJACOLICUS RU61A: A COFACTOR-
REMARK   1  TITL 4 DEVOID DIOXYGENASE OF THE ALPHA/BETA-HYDROLASE-
REMARK   1  TITL 5 FOLD SUPERFAMILY.
REMARK   1  REF    ACTA CRYSTALLOGR.,SECT.F      V.  63   382 2007
REMARK   1  REFN                   ISSN 1744-3091
REMARK   1  PMID   17565176
REMARK   1  DOI    10.1107/S174430910701353X
REMARK   2
REMARK   2 RESOLUTION.    2.09 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.5.0070
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.09
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 53.16
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL
REMARK   3   COMPLETENESS FOR RANGE        (%) : 97.5
REMARK   3   NUMBER OF REFLECTIONS             : 71190
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : TWIN LAW TAKEN INTO ACCOUNT
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.198
REMARK   3   R VALUE            (WORKING SET) : 0.196
REMARK   3   FREE R VALUE                     : 0.232
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.200
REMARK   3   FREE R VALUE TEST SET COUNT      : 3878
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.09
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.14
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 4166
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 77.67
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2810
REMARK   3   BIN FREE R VALUE SET COUNT          : 230
REMARK   3   BIN FREE R VALUE                    : 0.3450
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 8941
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 102
REMARK   3   SOLVENT ATOMS            : 279
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 41.20
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 32.15
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : 1.99000
REMARK   3    B22 (A**2) : -5.70000
REMARK   3    B33 (A**2) : 3.71000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.047
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.038
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.117
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 4.948
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.954
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.935
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  9323 ; 0.016 ; 0.021
REMARK   3   BOND LENGTHS OTHERS               (A):  6375 ; 0.002 ; 0.020
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 12689 ; 1.528 ; 1.948
REMARK   3   BOND ANGLES OTHERS          (DEGREES): 15387 ; 1.020 ; 3.001
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  1095 ; 6.464 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   487 ;37.133 ;23.388
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  1466 ;15.687 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    73 ;19.457 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  1299 ; 0.092 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A): 10433 ; 0.008 ; 0.021
REMARK   3   GENERAL PLANES OTHERS             (A):  1980 ; 0.003 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  5464 ; 0.624 ; 1.500
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  2191 ; 0.208 ; 1.500
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  8827 ; 1.107 ; 2.000
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  3859 ; 1.872 ; 3.000
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  3859 ; 2.898 ; 4.500
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : 1
REMARK   3
REMARK   3  NCS GROUP NUMBER               : 1
REMARK   3     CHAIN NAMES                    : A B C D
REMARK   3     NUMBER OF COMPONENTS NCS GROUP : 1
REMARK   3       COMPONENT C  SSSEQI  TO  C   SSSEQI   CODE
REMARK   3           1     A      5       A     274      3
REMARK   3           1     B      5       B     274      3
REMARK   3           1     C      5       C     274      3
REMARK   3           1     D      5       D     274      3
REMARK   3                   GROUP CHAIN        COUNT   RMS     WEIGHT
REMARK   3   TIGHT POSITIONAL   1    A    (A):   1575 ;  0.05 ;  0.05
REMARK   3   TIGHT POSITIONAL   1    B    (A):   1575 ;  0.05 ;  0.05
REMARK   3   TIGHT POSITIONAL   1    C    (A):   1575 ;  0.05 ;  0.05
REMARK   3   TIGHT POSITIONAL   1    D    (A):   1575 ;  0.05 ;  0.05
REMARK   3   LOOSE POSITIONAL   1    A    (A):   2162 ;  0.05 ;  5.00
REMARK   3   LOOSE POSITIONAL   1    B    (A):   2162 ;  0.04 ;  5.00
REMARK   3   LOOSE POSITIONAL   1    C    (A):   2162 ;  0.04 ;  5.00
REMARK   3   LOOSE POSITIONAL   1    D    (A):   2162 ;  0.04 ;  5.00
REMARK   3   TIGHT THERMAL      1    A (A**2):   1575 ;  0.17 ;  0.50
REMARK   3   TIGHT THERMAL      1    B (A**2):   1575 ;  0.16 ;  0.50
REMARK   3   TIGHT THERMAL      1    C (A**2):   1575 ;  0.18 ;  0.50
REMARK   3   TIGHT THERMAL      1    D (A**2):   1575 ;  0.16 ;  0.50
REMARK   3   LOOSE THERMAL      1    A (A**2):   2162 ;  0.14 ; 10.00
REMARK   3   LOOSE THERMAL      1    B (A**2):   2162 ;  0.14 ; 10.00
REMARK   3   LOOSE THERMAL      1    C (A**2):   2162 ;  0.14 ; 10.00
REMARK   3   LOOSE THERMAL      1    D (A**2):   2162 ;  0.13 ; 10.00
REMARK   3
REMARK   3  TWIN DETAILS
REMARK   3   NUMBER OF TWIN DOMAINS  : 2
REMARK   3      TWIN DOMAIN   : 1
REMARK   3      TWIN OPERATOR : H, K, L
REMARK   3      TWIN FRACTION : 0.510
REMARK   3      TWIN DOMAIN   : 2
REMARK   3      TWIN OPERATOR : -H, L, K
REMARK   3      TWIN FRACTION : 0.490
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE
REMARK   3  RIDING POSITIONS. U VALUES REFINED INDIVIDUALLY
REMARK   4
REMARK   4 2WJ3 COMPLIES WITH FORMAT V. 3.20, 01-DEC-08
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 20-MAY-09.
REMARK 100 THE PDBE ID CODE IS EBI-39878.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 23-JAN-09
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 7
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : DIAMOND
REMARK 200  BEAMLINE                       : I04
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9745
REMARK 200  MONOCHROMATOR                  : SI (111) DOUBLE CRYSTAL
REMARK 200  OPTICS                         : MIRRORS
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : MOSFLM
REMARK 200  DATA SCALING SOFTWARE          : SCALA
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 75553
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.09
REMARK 200  RESOLUTION RANGE LOW       (A) : 53.15
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 0.0
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.6
REMARK 200  DATA REDUNDANCY                : 4.4
REMARK 200  R MERGE                    (I) : 0.07
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 11.80
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.09
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.21
REMARK 200  COMPLETENESS FOR SHELL     (%) : 100.0
REMARK 200  DATA REDUNDANCY IN SHELL       : 4.4
REMARK 200  R MERGE FOR SHELL          (I) : 0.47
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 5.30
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: MOLREP
REMARK 200 STARTING MODEL: HOD H251A MUTANT SOLVED BY SAD IN SPACE
REMARK 200  GROUP P 43 21 2 AND NOT FULLY REFINED
REMARK 200
REMARK 200 REMARK: NONE
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS  (%): 49.21
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.44
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: HIS6-HOD AT 150 MG/ML IN
REMARK 280  STORAGE BUFFER IN THE PRESENCE OF A RESERVOIR COMPOSED OF
REMARK 280  1.65 M SODIUM/POTASSIUM  TARTRATE, 0.1 M HEPES PH 7.0
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X+1/2,-Y,Z+1/2
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       22.58500
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       84.01500
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       83.93000
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       84.01500
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       22.58500
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       83.93000
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3, 4
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY.  THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 GENERATING THE BIOMOLECULE
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE:  1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PQS
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE:  2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PQS
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE:  3
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PQS
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE:  4
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PQS
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 400
REMARK 400 COMPOUND
REMARK 400 ENGINEERED RESIDUE IN CHAIN A, CYS 69 TO SER
REMARK 400 ENGINEERED RESIDUE IN CHAIN B, CYS 69 TO SER
REMARK 400 ENGINEERED RESIDUE IN CHAIN C, CYS 69 TO SER
REMARK 400 ENGINEERED RESIDUE IN CHAIN D, CYS 69 TO SER
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A     1
REMARK 465     GLN A   276
REMARK 465     MET B     1
REMARK 465     THR B     2
REMARK 465     GLN B   276
REMARK 465     MET C     1
REMARK 465     GLY C   275
REMARK 465     GLN C   276
REMARK 465     MET D     1
REMARK 465     GLY D   275
REMARK 465     GLN D   276
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   OD1  ASP B   158     O    HOH B  2036              2.13
REMARK 500   O    GLU D     8     O    HOH D  2002              2.16
REMARK 500   O    HOH D  2006     O    HOH D  2015              2.05
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    PRO A  97   C   -  N   -  CD  ANGL. DEV. = -14.6 DEGREES
REMARK 500    ASP A 165   CB  -  CG  -  OD1 ANGL. DEV. =   5.4 DEGREES
REMARK 500    ARG A 260   NE  -  CZ  -  NH1 ANGL. DEV. =  -3.6 DEGREES
REMARK 500    ARG A 260   NE  -  CZ  -  NH2 ANGL. DEV. =   3.5 DEGREES
REMARK 500    PRO B  97   C   -  N   -  CD  ANGL. DEV. = -15.1 DEGREES
REMARK 500    ARG B 260   NE  -  CZ  -  NH1 ANGL. DEV. =  -4.0 DEGREES
REMARK 500    ARG B 260   NE  -  CZ  -  NH2 ANGL. DEV. =   4.4 DEGREES
REMARK 500    PRO C  97   C   -  N   -  CD  ANGL. DEV. = -18.2 DEGREES
REMARK 500    ARG C 260   NE  -  CZ  -  NH1 ANGL. DEV. =  -3.6 DEGREES
REMARK 500    PRO D  97   C   -  N   -  CD  ANGL. DEV. = -15.2 DEGREES
REMARK 500    ARG D 260   NE  -  CZ  -  NH1 ANGL. DEV. =  -3.5 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    PHE A  12     -122.78     45.55
REMARK 500    GLU A  93      -62.55    -97.33
REMARK 500    SER A 101     -123.16     41.18
REMARK 500    ASP A 126       68.58     35.43
REMARK 500    LEU A 128      101.89    -59.82
REMARK 500    PHE A 252       74.86   -116.80
REMARK 500    PHE B  12     -126.57     44.87
REMARK 500    GLN B  22       25.02     47.89
REMARK 500    HIS B  40      -18.52    -48.67
REMARK 500    GLU B  93      -63.80    -96.66
REMARK 500    SER B 101     -122.34     37.83
REMARK 500    ASP B 126       64.97     36.59
REMARK 500    LEU B 128      101.42    -58.21
REMARK 500    PHE B 252       71.64   -117.18
REMARK 500    GLN B 274       51.47   -116.08
REMARK 500    PHE C  12     -123.88     46.80
REMARK 500    GLN C  22       24.57     48.49
REMARK 500    GLU C  93      -68.28    -94.19
REMARK 500    SER C 101     -124.53     36.95
REMARK 500    ASP C 126       69.09     38.63
REMARK 500    LEU C 128      105.04    -57.81
REMARK 500    ARG C 148       17.56   -140.01
REMARK 500    HIS C 251       -9.10    -55.10
REMARK 500    PHE C 252       75.93   -118.34
REMARK 500    PHE D  12     -128.73     47.58
REMARK 500    ASP D  20      114.21   -160.01
REMARK 500    GLN D  22       25.67     48.89
REMARK 500    GLU D  93      -66.09    -94.37
REMARK 500    SER D 101     -123.51     36.18
REMARK 500    ASP D 126       70.17     37.83
REMARK 500    ARG D 148       16.19   -140.10
REMARK 500    HIS D 251       -6.80    -59.83
REMARK 500    PHE D 252       74.39   -116.65
REMARK 500
REMARK 500 REMARK: NULL
REMARK 600
REMARK 600 HETEROGEN
REMARK 600 GLYCEROL (GOL): PRESENT IN THE SOLUTION FOR CRYOPROTECTION
REMARK 600 D(-)-TARTARIC ACID (TAR): PRESENT IN THE CRYSTALLIZATION
REMARK 600  CONDITION
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL A1276
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B1276
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SRT A1277
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SRT B1277
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SRT C1275
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SRT D1275
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SRT C1276
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SRT B1278
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SRT D1276
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SRT A1278
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 2WM2   RELATED DB: PDB
REMARK 900  CRYSTAL STRUCTURE OF THE COFACTOR-DEVOID 1-
REMARK 900  H-3-HYDROXY-4-OXOQUINALDINE 2,4-
REMARK 900  DIOXYGENASE (HOD) FROM ARTHROBACTER
REMARK 900  NITROGUAJACOLICUS RU61A IN COMPLEX WITH
REMARK 900  CHLORIDE
REMARK 900 RELATED ID: 2WJ4   RELATED DB: PDB
REMARK 900  CRYSTAL STRUCTURE OF THE COFACTOR-DEVOID 1-
REMARK 900  H-3-HYDROXY-4-OXOQUINALDINE 2,4-
REMARK 900  DIOXYGENASE (HOD) FROM ARTHROBACTER
REMARK 900  NITROGUAJACOLICUS RU61A ANAEROBICALLY COMPLEXED
REMARK 900  WITH ITS NATURAL SUBSTRATE 1-H-3-HYDROXY-
REMARK 900  4-OXOQUINALDINE
REMARK 900 RELATED ID: 2WJ6   RELATED DB: PDB
REMARK 900  CRYSTAL STRUCTURE OF THE COFACTOR-DEVOID 1-
REMARK 900  H-3-HYDROXY-4-OXOQUINALDINE 2,4-
REMARK 900  DIOXYGENASE (HOD) FROM ARTHROBACTER
REMARK 900  NITROGUAJACOLICUS RU61A COMPLEXED WITH ITS
REMARK 900  NATURAL SUBSTRATE N-ACETYLANTHRANILATE
DBREF  2WJ3 A    1   276  UNP    A4V8M9   A4V8M9_9MICC     1    276
DBREF  2WJ3 B    1   276  UNP    A4V8M9   A4V8M9_9MICC     1    276
DBREF  2WJ3 C    1   276  UNP    A4V8M9   A4V8M9_9MICC     1    276
DBREF  2WJ3 D    1   276  UNP    A4V8M9   A4V8M9_9MICC     1    276
SEQADV 2WJ3 SER A   69  UNP  A4V8M9    CYS    69 ENGINEERED MUTATION
SEQADV 2WJ3 SER B   69  UNP  A4V8M9    CYS    69 ENGINEERED MUTATION
SEQADV 2WJ3 SER C   69  UNP  A4V8M9    CYS    69 ENGINEERED MUTATION
SEQADV 2WJ3 SER D   69  UNP  A4V8M9    CYS    69 ENGINEERED MUTATION
SEQRES   1 A  276  MET THR ASP THR TYR LEU HIS GLU THR LEU VAL PHE ASP
SEQRES   2 A  276  ASN LYS LEU SER TYR ILE ASP ASN GLN ARG ASP THR ASP
SEQRES   3 A  276  GLY PRO ALA ILE LEU LEU LEU PRO GLY TRP CYS HIS ASP
SEQRES   4 A  276  HIS ARG VAL TYR LYS TYR LEU ILE GLN GLU LEU ASP ALA
SEQRES   5 A  276  ASP PHE ARG VAL ILE VAL PRO ASN TRP ARG GLY HIS GLY
SEQRES   6 A  276  LEU SER PRO SER GLU VAL PRO ASP PHE GLY TYR GLN GLU
SEQRES   7 A  276  GLN VAL LYS ASP ALA LEU GLU ILE LEU ASP GLN LEU GLY
SEQRES   8 A  276  VAL GLU THR PHE LEU PRO VAL SER HIS SER HIS GLY GLY
SEQRES   9 A  276  TRP VAL LEU VAL GLU LEU LEU GLU GLN ALA GLY PRO GLU
SEQRES  10 A  276  ARG ALA PRO ARG GLY ILE ILE MET ASP TRP LEU MET TRP
SEQRES  11 A  276  ALA PRO LYS PRO ASP PHE ALA LYS SER LEU THR LEU LEU
SEQRES  12 A  276  LYS ASP PRO GLU ARG TRP ARG GLU GLY THR HIS GLY LEU
SEQRES  13 A  276  PHE ASP VAL TRP LEU ASP GLY HIS ASP GLU LYS ARG VAL
SEQRES  14 A  276  ARG HIS HIS LEU LEU GLU GLU MET ALA ASP TYR GLY TYR
SEQRES  15 A  276  ASP CYS TRP GLY ARG SER GLY ARG VAL ILE GLU ASP ALA
SEQRES  16 A  276  TYR GLY ARG ASN GLY SER PRO MET GLN MET MET ALA ASN
SEQRES  17 A  276  LEU THR LYS THR ARG PRO ILE ARG HIS ILE PHE SER GLN
SEQRES  18 A  276  PRO THR GLU PRO GLU TYR GLU LYS ILE ASN SER ASP PHE
SEQRES  19 A  276  ALA GLU GLN HIS PRO TRP PHE SER TYR ALA LYS LEU GLY
SEQRES  20 A  276  GLY PRO THR HIS PHE PRO ALA ILE ASP VAL PRO ASP ARG
SEQRES  21 A  276  ALA ALA VAL HIS ILE ARG GLU PHE ALA THR ALA ILE ARG
SEQRES  22 A  276  GLN GLY GLN
SEQRES   1 B  276  MET THR ASP THR TYR LEU HIS GLU THR LEU VAL PHE ASP
SEQRES   2 B  276  ASN LYS LEU SER TYR ILE ASP ASN GLN ARG ASP THR ASP
SEQRES   3 B  276  GLY PRO ALA ILE LEU LEU LEU PRO GLY TRP CYS HIS ASP
SEQRES   4 B  276  HIS ARG VAL TYR LYS TYR LEU ILE GLN GLU LEU ASP ALA
SEQRES   5 B  276  ASP PHE ARG VAL ILE VAL PRO ASN TRP ARG GLY HIS GLY
SEQRES   6 B  276  LEU SER PRO SER GLU VAL PRO ASP PHE GLY TYR GLN GLU
SEQRES   7 B  276  GLN VAL LYS ASP ALA LEU GLU ILE LEU ASP GLN LEU GLY
SEQRES   8 B  276  VAL GLU THR PHE LEU PRO VAL SER HIS SER HIS GLY GLY
SEQRES   9 B  276  TRP VAL LEU VAL GLU LEU LEU GLU GLN ALA GLY PRO GLU
SEQRES  10 B  276  ARG ALA PRO ARG GLY ILE ILE MET ASP TRP LEU MET TRP
SEQRES  11 B  276  ALA PRO LYS PRO ASP PHE ALA LYS SER LEU THR LEU LEU
SEQRES  12 B  276  LYS ASP PRO GLU ARG TRP ARG GLU GLY THR HIS GLY LEU
SEQRES  13 B  276  PHE ASP VAL TRP LEU ASP GLY HIS ASP GLU LYS ARG VAL
SEQRES  14 B  276  ARG HIS HIS LEU LEU GLU GLU MET ALA ASP TYR GLY TYR
SEQRES  15 B  276  ASP CYS TRP GLY ARG SER GLY ARG VAL ILE GLU ASP ALA
SEQRES  16 B  276  TYR GLY ARG ASN GLY SER PRO MET GLN MET MET ALA ASN
SEQRES  17 B  276  LEU THR LYS THR ARG PRO ILE ARG HIS ILE PHE SER GLN
SEQRES  18 B  276  PRO THR GLU PRO GLU TYR GLU LYS ILE ASN SER ASP PHE
SEQRES  19 B  276  ALA GLU GLN HIS PRO TRP PHE SER TYR ALA LYS LEU GLY
SEQRES  20 B  276  GLY PRO THR HIS PHE PRO ALA ILE ASP VAL PRO ASP ARG
SEQRES  21 B  276  ALA ALA VAL HIS ILE ARG GLU PHE ALA THR ALA ILE ARG
SEQRES  22 B  276  GLN GLY GLN
SEQRES   1 C  276  MET THR ASP THR TYR LEU HIS GLU THR LEU VAL PHE ASP
SEQRES   2 C  276  ASN LYS LEU SER TYR ILE ASP ASN GLN ARG ASP THR ASP
SEQRES   3 C  276  GLY PRO ALA ILE LEU LEU LEU PRO GLY TRP CYS HIS ASP
SEQRES   4 C  276  HIS ARG VAL TYR LYS TYR LEU ILE GLN GLU LEU ASP ALA
SEQRES   5 C  276  ASP PHE ARG VAL ILE VAL PRO ASN TRP ARG GLY HIS GLY
SEQRES   6 C  276  LEU SER PRO SER GLU VAL PRO ASP PHE GLY TYR GLN GLU
SEQRES   7 C  276  GLN VAL LYS ASP ALA LEU GLU ILE LEU ASP GLN LEU GLY
SEQRES   8 C  276  VAL GLU THR PHE LEU PRO VAL SER HIS SER HIS GLY GLY
SEQRES   9 C  276  TRP VAL LEU VAL GLU LEU LEU GLU GLN ALA GLY PRO GLU
SEQRES  10 C  276  ARG ALA PRO ARG GLY ILE ILE MET ASP TRP LEU MET TRP
SEQRES  11 C  276  ALA PRO LYS PRO ASP PHE ALA LYS SER LEU THR LEU LEU
SEQRES  12 C  276  LYS ASP PRO GLU ARG TRP ARG GLU GLY THR HIS GLY LEU
SEQRES  13 C  276  PHE ASP VAL TRP LEU ASP GLY HIS ASP GLU LYS ARG VAL
SEQRES  14 C  276  ARG HIS HIS LEU LEU GLU GLU MET ALA ASP TYR GLY TYR
SEQRES  15 C  276  ASP CYS TRP GLY ARG SER GLY ARG VAL ILE GLU ASP ALA
SEQRES  16 C  276  TYR GLY ARG ASN GLY SER PRO MET GLN MET MET ALA ASN
SEQRES  17 C  276  LEU THR LYS THR ARG PRO ILE ARG HIS ILE PHE SER GLN
SEQRES  18 C  276  PRO THR GLU PRO GLU TYR GLU LYS ILE ASN SER ASP PHE
SEQRES  19 C  276  ALA GLU GLN HIS PRO TRP PHE SER TYR ALA LYS LEU GLY
SEQRES  20 C  276  GLY PRO THR HIS PHE PRO ALA ILE ASP VAL PRO ASP ARG
SEQRES  21 C  276  ALA ALA VAL HIS ILE ARG GLU PHE ALA THR ALA ILE ARG
SEQRES  22 C  276  GLN GLY GLN
SEQRES   1 D  276  MET THR ASP THR TYR LEU HIS GLU THR LEU VAL PHE ASP
SEQRES   2 D  276  ASN LYS LEU SER TYR ILE ASP ASN GLN ARG ASP THR ASP
SEQRES   3 D  276  GLY PRO ALA ILE LEU LEU LEU PRO GLY TRP CYS HIS ASP
SEQRES   4 D  276  HIS ARG VAL TYR LYS TYR LEU ILE GLN GLU LEU ASP ALA
SEQRES   5 D  276  ASP PHE ARG VAL ILE VAL PRO ASN TRP ARG GLY HIS GLY
SEQRES   6 D  276  LEU SER PRO SER GLU VAL PRO ASP PHE GLY TYR GLN GLU
SEQRES   7 D  276  GLN VAL LYS ASP ALA LEU GLU ILE LEU ASP GLN LEU GLY
SEQRES   8 D  276  VAL GLU THR PHE LEU PRO VAL SER HIS SER HIS GLY GLY
SEQRES   9 D  276  TRP VAL LEU VAL GLU LEU LEU GLU GLN ALA GLY PRO GLU
SEQRES  10 D  276  ARG ALA PRO ARG GLY ILE ILE MET ASP TRP LEU MET TRP
SEQRES  11 D  276  ALA PRO LYS PRO ASP PHE ALA LYS SER LEU THR LEU LEU
SEQRES  12 D  276  LYS ASP PRO GLU ARG TRP ARG GLU GLY THR HIS GLY LEU
SEQRES  13 D  276  PHE ASP VAL TRP LEU ASP GLY HIS ASP GLU LYS ARG VAL
SEQRES  14 D  276  ARG HIS HIS LEU LEU GLU GLU MET ALA ASP TYR GLY TYR
SEQRES  15 D  276  ASP CYS TRP GLY ARG SER GLY ARG VAL ILE GLU ASP ALA
SEQRES  16 D  276  TYR GLY ARG ASN GLY SER PRO MET GLN MET MET ALA ASN
SEQRES  17 D  276  LEU THR LYS THR ARG PRO ILE ARG HIS ILE PHE SER GLN
SEQRES  18 D  276  PRO THR GLU PRO GLU TYR GLU LYS ILE ASN SER ASP PHE
SEQRES  19 D  276  ALA GLU GLN HIS PRO TRP PHE SER TYR ALA LYS LEU GLY
SEQRES  20 D  276  GLY PRO THR HIS PHE PRO ALA ILE ASP VAL PRO ASP ARG
SEQRES  21 D  276  ALA ALA VAL HIS ILE ARG GLU PHE ALA THR ALA ILE ARG
SEQRES  22 D  276  GLN GLY GLN
HET    GOL  A1276       6
HET    GOL  B1276       6
HET    SRT  A1277      10
HET    SRT  B1277      10
HET    SRT  C1275      10
HET    SRT  D1275      10
HET    SRT  C1276      10
HET    SRT  B1278      10
HET    SRT  D1276      20
HET    SRT  A1278      10
HETNAM     GOL GLYCEROL
HETNAM     SRT S,R MESO-TARTARIC ACID
FORMUL   5  GOL    2(C3 H8 O3)
FORMUL   6  SRT    8(C4 H6 O6)
FORMUL   7  HOH   *279(H2 O)
HELIX    1   1 THR A    2  THR A    4  5                                   3
HELIX    2   2 ASP A   39  VAL A   42  5                                   4
HELIX    3   3 TYR A   43  ASP A   51  1                                   9
HELIX    4   4 GLY A   75  LEU A   90  1                                  16
HELIX    5   5 GLY A  103  ALA A  119  1                                  17
HELIX    6   6 LYS A  133  ASP A  145  1                                  13
HELIX    7   7 ARG A  148  ASP A  162  1                                  15
HELIX    8   8 GLU A  166  GLU A  175  1                                  10
HELIX    9   9 GLY A  181  GLY A  200  1                                  20
HELIX   10  10 SER A  201  ASN A  208  1                                   8
HELIX   11  11 GLU A  224  HIS A  238  1                                  15
HELIX   12  12 PHE A  252  VAL A  257  1                                   6
HELIX   13  13 VAL A  257  ARG A  273  1                                  17
HELIX   14  14 ASP B   39  VAL B   42  5                                   4
HELIX   15  15 TYR B   43  ASP B   51  1                                   9
HELIX   16  16 GLY B   75  GLY B   91  1                                  17
HELIX   17  17 GLY B  103  ALA B  119  1                                  17
HELIX   18  18 LYS B  133  ASP B  145  1                                  13
HELIX   19  19 ARG B  148  ASP B  162  1                                  15
HELIX   20  20 GLU B  166  GLU B  175  1                                  10
HELIX   21  21 GLY B  181  GLY B  200  1                                  20
HELIX   22  22 SER B  201  ASN B  208  1                                   8
HELIX   23  23 GLU B  224  HIS B  238  1                                  15
HELIX   24  24 PHE B  252  VAL B  257  1                                   6
HELIX   25  25 VAL B  257  ARG B  273  1                                  17
HELIX   26  26 THR C    2  THR C    4  5                                   3
HELIX   27  27 ASP C   39  VAL C   42  5                                   4
HELIX   28  28 TYR C   43  ASP C   51  1                                   9
HELIX   29  29 GLY C   75  GLY C   91  1                                  17
HELIX   30  30 HIS C  102  ALA C  119  1                                  18
HELIX   31  31 LYS C  133  ASP C  145  1                                  13
HELIX   32  32 ARG C  148  ASP C  162  1                                  15
HELIX   33  33 GLU C  166  GLU C  175  1                                  10
HELIX   34  34 GLY C  181  GLY C  200  1                                  20
HELIX   35  35 SER C  201  ASN C  208  1                                   8
HELIX   36  36 GLU C  224  HIS C  238  1                                  15
HELIX   37  37 PHE C  252  VAL C  257  1                                   6
HELIX   38  38 VAL C  257  ARG C  273  1                                  17
HELIX   39  39 ASP D   39  VAL D   42  5                                   4
HELIX   40  40 TYR D   43  ASP D   51  1                                   9
HELIX   41  41 GLY D   75  LEU D   90  1                                  16
HELIX   42  42 HIS D  102  ALA D  119  1                                  18
HELIX   43  43 LYS D  133  ASP D  145  1                                  13
HELIX   44  44 ARG D  148  ASP D  162  1                                  15
HELIX   45  45 GLU D  166  GLU D  175  1                                  10
HELIX   46  46 GLY D  181  GLY D  200  1                                  20
HELIX   47  47 SER D  201  ASN D  208  1                                   8
HELIX   48  48 GLU D  224  HIS D  238  1                                  15
HELIX   49  49 PHE D  252  VAL D  257  1                                   6
HELIX   50  50 VAL D  257  ARG D  273  1                                  17
SHEET    1  AA 8 LEU A   6  VAL A  11  0
SHEET    2  AA 8 ASN A  14  ASP A  20 -1  O  ASN A  14   N  VAL A  11
SHEET    3  AA 8 VAL A  56  PRO A  59 -1  O  VAL A  58   N  ILE A  19
SHEET    4  AA 8 ALA A  29  LEU A  33  1  O  ILE A  30   N  ILE A  57
SHEET    5  AA 8 PHE A  95  HIS A 100  1  O  LEU A  96   N  LEU A  31
SHEET    6  AA 8 GLY A 122  MET A 125  1  O  ILE A 123   N  SER A  99
SHEET    7  AA 8 ILE A 215  PHE A 219  1  O  ARG A 216   N  ILE A 124
SHEET    8  AA 8 PHE A 241  LYS A 245  1  O  SER A 242   N  HIS A 217
SHEET    1  BA 8 LEU B   6  VAL B  11  0
SHEET    2  BA 8 ASN B  14  ASP B  20 -1  O  ASN B  14   N  VAL B  11
SHEET    3  BA 8 VAL B  56  PRO B  59 -1  O  VAL B  58   N  ILE B  19
SHEET    4  BA 8 ALA B  29  LEU B  33  1  O  ILE B  30   N  ILE B  57
SHEET    5  BA 8 PHE B  95  HIS B 100  1  O  LEU B  96   N  LEU B  31
SHEET    6  BA 8 GLY B 122  MET B 125  1  O  ILE B 123   N  SER B  99
SHEET    7  BA 8 ILE B 215  PHE B 219  1  O  ARG B 216   N  ILE B 124
SHEET    8  BA 8 PHE B 241  LYS B 245  1  O  SER B 242   N  HIS B 217
SHEET    1  CA 8 LEU C   6  VAL C  11  0
SHEET    2  CA 8 ASN C  14  ASP C  20 -1  O  ASN C  14   N  VAL C  11
SHEET    3  CA 8 VAL C  56  PRO C  59 -1  O  VAL C  58   N  ILE C  19
SHEET    4  CA 8 ALA C  29  LEU C  33  1  O  ILE C  30   N  ILE C  57
SHEET    5  CA 8 PHE C  95  HIS C 100  1  O  LEU C  96   N  LEU C  31
SHEET    6  CA 8 GLY C 122  MET C 125  1  O  ILE C 123   N  SER C  99
SHEET    7  CA 8 ILE C 215  PHE C 219  1  O  ARG C 216   N  ILE C 124
SHEET    8  CA 8 PHE C 241  LYS C 245  1  O  SER C 242   N  HIS C 217
SHEET    1  DA 8 LEU D   6  VAL D  11  0
SHEET    2  DA 8 ASN D  14  ASP D  20 -1  O  ASN D  14   N  VAL D  11
SHEET    3  DA 8 VAL D  56  PRO D  59 -1  O  VAL D  58   N  ILE D  19
SHEET    4  DA 8 ALA D  29  LEU D  33  1  O  ILE D  30   N  ILE D  57
SHEET    5  DA 8 PHE D  95  HIS D 100  1  O  LEU D  96   N  LEU D  31
SHEET    6  DA 8 GLY D 122  MET D 125  1  O  ILE D 123   N  SER D  99
SHEET    7  DA 8 ILE D 215  PHE D 219  1  O  ARG D 216   N  ILE D 124
SHEET    8  DA 8 PHE D 241  LYS D 245  1  O  SER D 242   N  HIS D 217
SSBOND   1 CYS A   37    CYS A  184                          1555   1555  2.08
SSBOND   2 CYS B   37    CYS B  184                          1555   1555  2.08
SSBOND   3 CYS C   37    CYS C  184                          1555   1555  2.14
SSBOND   4 CYS D   37    CYS D  184                          1555   1555  2.06
CISPEP   1 GLY A   27    PRO A   28          0         0.47
CISPEP   2 GLN A  221    PRO A  222          0        -5.50
CISPEP   3 GLY B   27    PRO B   28          0         0.48
CISPEP   4 GLN B  221    PRO B  222          0        -6.81
CISPEP   5 GLY C   27    PRO C   28          0         3.00
CISPEP   6 GLN C  221    PRO C  222          0       -13.68
CISPEP   7 GLY D   27    PRO D   28          0         1.99
CISPEP   8 GLN D  221    PRO D  222          0        -8.85
SITE     1 AC1  3 ALA A 235  TYR A 243  ASP D 158
SITE     1 AC2  9 SER B 101  HIS B 102  ASP B 126  TRP B 127
SITE     2 AC2  9 LEU B 128  PHE B 136  TRP B 160  HIS B 251
SITE     3 AC2  9 HOH B2026
SITE     1 AC3  5 LYS A 167  ARG A 170  HIS A 171  ARG C 260
SITE     2 AC3  5 VAL C 263
SITE     1 AC4  5 LYS B 167  ARG B 170  HIS B 171  ARG D 260
SITE     2 AC4  5 VAL D 263
SITE     1 AC5  5 ARG B 260  VAL B 263  LYS C 167  ARG C 170
SITE     2 AC5  5 HIS C 171
SITE     1 AC6  5 ARG A 260  VAL A 263  LYS D 167  ARG D 170
SITE     2 AC6  5 HIS D 171
SITE     1 AC7  8 HIS A 164  ASP A 165  LYS C 245  LEU C 246
SITE     2 AC7  8 GLY C 247  HOH C2086  HOH C2087  HOH C2088
SITE     1 AC8 10 LYS B 245  LEU B 246  GLY B 247  HOH B2069
SITE     2 AC8 10 HOH B2070  HOH B2071  GLY C 163  HIS C 164
SITE     3 AC8 10 ASP C 165  GLU C 166
SITE     1 AC9  8 HIS B 164  ASP B 165  HOH B2040  LYS D 245
SITE     2 AC9  8 LEU D 246  GLY D 247  HOH D2055  HOH D2056
SITE     1 BC1  7 LYS A 245  LEU A 246  GLY A 247  HOH A2064
SITE     2 BC1  7 HIS D 164  ASP D 165  GLU D 166
CRYST1   45.170  167.860  168.030  90.00  90.00  90.00 P 21 21 21   16
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.022139  0.000000  0.000000        0.00000
SCALE2      0.000000  0.005957  0.000000        0.00000
SCALE3      0.000000  0.000000  0.005951        0.00000
MTRIX1   1  0.999090  0.031360  0.028950       -3.56611    1
MTRIX2   1 -0.030480  0.999070 -0.030360       71.48642    1
MTRIX3   1 -0.029870  0.029450  0.999120      -68.47247    1
MTRIX1   2  0.999410 -0.033290  0.007960       -9.02991    1
MTRIX2   2 -0.007000  0.028770  0.999560       23.85075    1
MTRIX3   2 -0.033510 -0.999030  0.028520      124.84000    1
MTRIX1   3  0.999490 -0.003410  0.031650      -14.87078    1
MTRIX2   3 -0.031620  0.006680  0.999480      -41.87589    1
MTRIX3   3 -0.003620 -0.999970  0.006570       56.86059    1
TER    2235      GLY A 275
TER    4469      GLY B 275
TER    6706      GLN C 274
TER    8945      GLN D 274
MASTER      489    0   10   50   32    0   21   15 9322    4  110   88
END