longtext: 2YH2-pdb

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HEADER    HYDROLASE                               27-APR-11   2YH2
TITLE     PYROBACULUM CALIDIFONTIS ESTERASE MONOCLINIC FORM
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: ESTERASE;
COMPND   3 CHAIN: A, B, C, D;
COMPND   4 SYNONYM: ALPH-BETA HYDROLASE;
COMPND   5 EC: 3.1.1.1;
COMPND   6 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: PYROBACULUM CALIDIFONTIS;
SOURCE   3 ORGANISM_TAXID: 181486;
SOURCE   4 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   5 EXPRESSION_SYSTEM_TAXID: 511693;
SOURCE   6 EXPRESSION_SYSTEM_STRAIN: BL21;
SOURCE   7 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID
KEYWDS    HYPERTHERMOPHILIC ENZYME, HYDROLASE, TERTIARY ALCOHOL, ALPHA/BETA
KEYWDS   2 HYDROLASE FOLD
EXPDTA    X-RAY DIFFRACTION
AUTHOR    G.PALM,X.BOGDANOVIC,W.HINRICHS
REVDAT   1   18-MAY-11 2YH2    0
JRNL        AUTH   G.J.PALM,E.FERNANDEZ-ALVARO,X.BOGDANOVIC,S.BARTSCH,
JRNL        AUTH 2 J.SCZODROK,R.K.SINGH,D.BOETTCHER,H.ATOMI,U.T.BORNSCHEUER,
JRNL        AUTH 3 W.HINRICHS
JRNL        TITL   THE CRYSTAL STRUCTURE OF AN ESTERASE FOM THE
JRNL        TITL 2 HYPERTHERMOPHILIC MICROORGANISM PYROBACULUM CALIDIFONTIS
JRNL        TITL 3 VA1 SUPPORTS EXPLANATION OF ITS ENANTIOSELECTIVITY.
JRNL        REF    APPL.MICROBIOL.BIOTECHNOL.                 2011
JRNL        REFN                   ESSN 1432-0614
REMARK   1
REMARK   1 REFERENCE 1
REMARK   1  AUTH   Y.HOTTA,S.EZAKI,H.ATOMI,T.IMANAKA
REMARK   1  TITL   EXTREMELY STABLE AND VERSATILE CARBOXYLESTERASE FROM A
REMARK   1  TITL 2 HYPERTHERMOPHILIC ARCHAEON.
REMARK   1  REF    APPL.ENVIRON.MICROBIOL.       V.  68  3925 2002
REMARK   1  REFN                   ISSN 0099-2240
REMARK   1  PMID   12147492
REMARK   2
REMARK   2 RESOLUTION.    2.20 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.5.0109
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.20
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 141.87
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NONE
REMARK   3   COMPLETENESS FOR RANGE        (%) : 84.82
REMARK   3   NUMBER OF REFLECTIONS             : 47721
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.16668
REMARK   3   R VALUE            (WORKING SET) : 0.16416
REMARK   3   FREE R VALUE                     : 0.21370
REMARK   3   FREE R VALUE TEST SET SIZE   (%) :  5.1
REMARK   3   FREE R VALUE TEST SET COUNT      : 2550
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.198
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.255
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 1716
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 41.71
REMARK   3   BIN R VALUE           (WORKING SET) : 0.167
REMARK   3   BIN FREE R VALUE SET COUNT          : 89
REMARK   3   BIN FREE R VALUE                    : 0.252
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 9580
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 5
REMARK   3   SOLVENT ATOMS            : 368
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 17.6
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 16.688
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : 2.21
REMARK   3    B22 (A**2) : -2.08
REMARK   3    B33 (A**2) : -0.13
REMARK   3    B12 (A**2) : 0.00
REMARK   3    B13 (A**2) : -0.32
REMARK   3    B23 (A**2) : 0.00
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.435
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.231
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.135
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 11.584
REMARK   3
REMARK   3  CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.949
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.915
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  9813 ; 0.010 ; 0.022
REMARK   3   BOND LENGTHS OTHERS               (A):  6674 ; 0.001 ; 0.020
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 13367 ; 1.198 ; 1.967
REMARK   3   BOND ANGLES OTHERS          (DEGREES): 16179 ; 0.873 ; 3.000
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  1240 ; 5.663 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   441 ;30.566 ;22.834
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  1550 ;13.996 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    88 ;16.220 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  1489 ; 0.070 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A): 11049 ; 0.005 ; 0.021
REMARK   3   GENERAL PLANES OTHERS             (A):  2059 ; 0.001 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  6159 ; 0.432 ; 1.500
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  2486 ; 0.097 ; 1.500
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  9934 ; 0.810 ; 2.000
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  3654 ; 1.402 ; 3.000
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  3425 ; 2.310 ; 4.500
REMARK   3
REMARK   3  ANISOTROPIC THERMAL FACTOR RESTRAINTS.   COUNT   RMS    WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 8
REMARK   3
REMARK   3   TLS GROUP : 1
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A     1        A    27
REMARK   3    ORIGIN FOR THE GROUP (A):  35.6880  12.0590  42.7390
REMARK   3    T TENSOR
REMARK   3      T11:   0.1655 T22:   0.2383
REMARK   3      T33:   0.3198 T12:  -0.0618
REMARK   3      T13:   0.1284 T23:  -0.0666
REMARK   3    L TENSOR
REMARK   3      L11:  -0.4006 L22:   9.4239
REMARK   3      L33:   2.5264 L12:  -1.0369
REMARK   3      L13:  -0.1761 L23:   1.1932
REMARK   3    S TENSOR
REMARK   3      S11:   0.0232 S12:  -0.0230 S13:   0.0862
REMARK   3      S21:  -0.7006 S22:   0.2327 S23:  -0.9512
REMARK   3      S31:  -0.1943 S32:   0.5669 S33:  -0.2559
REMARK   3
REMARK   3   TLS GROUP : 2
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A    28        A   313
REMARK   3    ORIGIN FOR THE GROUP (A):  20.0180   1.1470  52.0500
REMARK   3    T TENSOR
REMARK   3      T11:   0.1434 T22:   0.0625
REMARK   3      T33:   0.0285 T12:   0.0045
REMARK   3      T13:   0.0310 T23:   0.0015
REMARK   3    L TENSOR
REMARK   3      L11:   0.5083 L22:   0.5735
REMARK   3      L33:   0.6160 L12:  -0.0389
REMARK   3      L13:   0.0609 L23:   0.0470
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0001 S12:   0.0173 S13:  -0.0465
REMARK   3      S21:  -0.0259 S22:  -0.0148 S23:  -0.0150
REMARK   3      S31:   0.0384 S32:   0.0318 S33:   0.0149
REMARK   3
REMARK   3   TLS GROUP : 3
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   B     2        B    27
REMARK   3    ORIGIN FOR THE GROUP (A):  -7.5310  27.6770  45.7740
REMARK   3    T TENSOR
REMARK   3      T11:   0.1353 T22:   0.3894
REMARK   3      T33:   0.4221 T12:   0.0189
REMARK   3      T13:   0.0134 T23:   0.0359
REMARK   3    L TENSOR
REMARK   3      L11:   1.5680 L22:  19.6498
REMARK   3      L33:   4.1502 L12:  -5.3996
REMARK   3      L13:  -0.2600 L23:   4.9003
REMARK   3    S TENSOR
REMARK   3      S11:   0.2370 S12:   0.2551 S13:  -0.5263
REMARK   3      S21:  -0.8971 S22:  -0.8627 S23:   2.1343
REMARK   3      S31:  -0.2545 S32:  -0.6488 S33:   0.6257
REMARK   3
REMARK   3   TLS GROUP : 4
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   B    28        B   313
REMARK   3    ORIGIN FOR THE GROUP (A):   8.5410  32.1480  59.3640
REMARK   3    T TENSOR
REMARK   3      T11:   0.1414 T22:   0.0692
REMARK   3      T33:   0.0260 T12:   0.0040
REMARK   3      T13:   0.0347 T23:  -0.0077
REMARK   3    L TENSOR
REMARK   3      L11:   0.4397 L22:   0.6685
REMARK   3      L33:   0.6034 L12:   0.0802
REMARK   3      L13:  -0.1130 L23:   0.0198
REMARK   3    S TENSOR
REMARK   3      S11:   0.0121 S12:  -0.0030 S13:   0.0102
REMARK   3      S21:  -0.0142 S22:  -0.0213 S23:   0.0218
REMARK   3      S31:  -0.0536 S32:  -0.0239 S33:   0.0092
REMARK   3
REMARK   3   TLS GROUP : 5
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   C     2        C    27
REMARK   3    ORIGIN FOR THE GROUP (A):  36.3260  27.3750  25.7890
REMARK   3    T TENSOR
REMARK   3      T11:   0.4717 T22:   0.5972
REMARK   3      T33:   0.8825 T12:   0.2289
REMARK   3      T13:  -0.0611 T23:  -0.1827
REMARK   3    L TENSOR
REMARK   3      L11:   0.5498 L22:  39.4352
REMARK   3      L33:   0.9447 L12:   9.2624
REMARK   3      L13:   0.1556 L23:   0.5998
REMARK   3    S TENSOR
REMARK   3      S11:   0.3535 S12:   0.0217 S13:  -0.5905
REMARK   3      S21:   1.5238 S22:   0.0273 S23:  -3.8482
REMARK   3      S31:   0.6422 S32:   0.8277 S33:  -0.3808
REMARK   3
REMARK   3   TLS GROUP : 6
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   C    28        C   313
REMARK   3    ORIGIN FOR THE GROUP (A):  20.8990  41.3030  18.9040
REMARK   3    T TENSOR
REMARK   3      T11:   0.1595 T22:   0.0686
REMARK   3      T33:   0.0237 T12:  -0.0049
REMARK   3      T13:   0.0461 T23:   0.0036
REMARK   3    L TENSOR
REMARK   3      L11:   0.4072 L22:   0.8220
REMARK   3      L33:   0.7968 L12:   0.0512
REMARK   3      L13:  -0.0627 L23:   0.0371
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0042 S12:   0.0174 S13:   0.0251
REMARK   3      S21:  -0.0170 S22:  -0.0014 S23:  -0.0328
REMARK   3      S31:  -0.0974 S32:   0.0371 S33:   0.0056
REMARK   3
REMARK   3   TLS GROUP : 7
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   D     2        D    27
REMARK   3    ORIGIN FOR THE GROUP (A):  -7.4710  16.4550  24.8310
REMARK   3    T TENSOR
REMARK   3      T11:   0.1565 T22:   0.3973
REMARK   3      T33:   0.2274 T12:  -0.0117
REMARK   3      T13:   0.1068 T23:   0.0603
REMARK   3    L TENSOR
REMARK   3      L11:   2.9433 L22:  17.6537
REMARK   3      L33:   4.4234 L12:   6.6180
REMARK   3      L13:   0.7541 L23:   4.3619
REMARK   3    S TENSOR
REMARK   3      S11:   0.5105 S12:  -0.3871 S13:   0.3556
REMARK   3      S21:   1.1795 S22:  -0.8178 S23:   1.3065
REMARK   3      S31:   0.2499 S32:  -0.9048 S33:   0.3074
REMARK   3
REMARK   3   TLS GROUP : 8
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   D    28        D   313
REMARK   3    ORIGIN FOR THE GROUP (A):   8.2650  10.5970  11.7310
REMARK   3    T TENSOR
REMARK   3      T11:   0.1437 T22:   0.0678
REMARK   3      T33:   0.0110 T12:  -0.0020
REMARK   3      T13:   0.0209 T23:  -0.0011
REMARK   3    L TENSOR
REMARK   3      L11:   0.5170 L22:   0.6499
REMARK   3      L33:   1.2238 L12:  -0.0439
REMARK   3      L13:   0.1389 L23:  -0.0238
REMARK   3    S TENSOR
REMARK   3      S11:   0.0517 S12:   0.0167 S13:  -0.0211
REMARK   3      S21:  -0.0056 S22:   0.0107 S23:   0.0265
REMARK   3      S31:   0.1399 S32:  -0.0669 S33:  -0.0624
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.40
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE
REMARK   3   RIDING POSITIONS.
REMARK   4
REMARK   4 2YH2 COMPLIES WITH FORMAT V. 3.20, 01-DEC-08
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 27-APR-11.
REMARK 100 THE PDBE ID CODE IS EBI-48083.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 01-MAR-09
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 8.0
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : EMBL/DESY, HAMBURG
REMARK 200  BEAMLINE                       : X12
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.97784
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : MARRESEARCH
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : MOSFLM 7.0.4
REMARK 200  DATA SCALING SOFTWARE          : SCALA
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 50355
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.20
REMARK 200  RESOLUTION RANGE LOW       (A) : 10.00
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : -3.0
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 85.0
REMARK 200  DATA REDUNDANCY                : 5
REMARK 200  R MERGE                    (I) : 0.10
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 5.30
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.20
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.25
REMARK 200  COMPLETENESS FOR SHELL     (%) : 47.0
REMARK 200  DATA REDUNDANCY IN SHELL       : 3.6
REMARK 200  R MERGE FOR SHELL          (I) : 0.20
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 3.50
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: PDB ENTRY 2WIR
REMARK 200
REMARK 200 REMARK: NONE
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 43
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.14
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 10% PEG 4000, 30% MPD, 0.1 M
REMARK 280  IMIDAZOLE PH 8.0; SOAKED IN 10% PEG 4000, 4% DMSO, 0.1 M
REMARK 280  IMIDAZOLE PH 8.0, 0.01 M PHENYLBUTANOIC ACID ETHYL ESTER.
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       36.16750
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 8740 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 42380 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -54.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     ALA A    15
REMARK 465     ALA A    16
REMARK 465     GLN A    17
REMARK 465     LEU A    18
REMARK 465     GLN A    19
REMARK 465     MET B     1
REMARK 465     LEU B    14
REMARK 465     ALA B    15
REMARK 465     ALA B    16
REMARK 465     GLN B    17
REMARK 465     LEU B    18
REMARK 465     MET C     1
REMARK 465     GLN C    17
REMARK 465     LEU C    18
REMARK 465     GLN C    19
REMARK 465     PHE C    20
REMARK 465     ARG C    21
REMARK 465     PRO C    22
REMARK 465     ASP C    23
REMARK 465     MET D     1
REMARK 465     ALA D    15
REMARK 465     ALA D    16
REMARK 465     GLN D    17
REMARK 465     LEU D    18
REMARK 465     GLN D    19
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    GLN A  12       29.69    -72.49
REMARK 500    SER A  91     -177.10   -172.77
REMARK 500    SER A 157     -117.72     61.84
REMARK 500    TYR A 185       66.20     28.09
REMARK 500    VAL A 207      -61.69     68.63
REMARK 500    TYR A 253       68.35   -105.97
REMARK 500    GLN B  12       89.62    -65.78
REMARK 500    SER B 157     -116.08     67.26
REMARK 500    TYR B 185       62.96     30.09
REMARK 500    VAL B 207      -59.03     67.72
REMARK 500    TYR B 253       57.77   -104.64
REMARK 500    LEU C  14      -36.57   -165.99
REMARK 500    ALA C  15      -72.80    -60.35
REMARK 500    ASN C  45       59.17     38.82
REMARK 500    SER C 157     -116.34     65.06
REMARK 500    TYR C 185       63.06     33.15
REMARK 500    VAL C 207      -62.50     65.11
REMARK 500    TYR C 253       60.49   -106.72
REMARK 500    SER D 157     -117.74     63.82
REMARK 500    TYR D 185       65.27     27.97
REMARK 500    VAL D 207      -56.84     64.70
REMARK 500    TYR D 253       53.95   -105.08
REMARK 500
REMARK 500 REMARK: NULL
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A1314
REMARK 800
REMARK 800 SITE_IDENTIFIER: ASA
REMARK 800 EVIDENCE_CODE: AUTHOR
REMARK 800 SITE_DESCRIPTION: CATALYTIC TRIAD IN MONOMER A
REMARK 800
REMARK 800 SITE_IDENTIFIER: ASB
REMARK 800 EVIDENCE_CODE: AUTHOR
REMARK 800 SITE_DESCRIPTION: CATALYTIC TRIAD IN MONOMER B
REMARK 800
REMARK 800 SITE_IDENTIFIER: ASC
REMARK 800 EVIDENCE_CODE: AUTHOR
REMARK 800 SITE_DESCRIPTION: CATALYTIC TRIAD IN MONOMER C
REMARK 800
REMARK 800 SITE_IDENTIFIER: ASD
REMARK 800 EVIDENCE_CODE: AUTHOR
REMARK 800 SITE_DESCRIPTION: CATALYTIC TRIAD IN MONOMER D
DBREF  2YH2 A    1   313  UNP    Q8NKS0   Q8NKS0_9CREN     1    313
DBREF  2YH2 B    1   313  UNP    Q8NKS0   Q8NKS0_9CREN     1    313
DBREF  2YH2 C    1   313  UNP    Q8NKS0   Q8NKS0_9CREN     1    313
DBREF  2YH2 D    1   313  UNP    Q8NKS0   Q8NKS0_9CREN     1    313
SEQRES   1 A  313  MET PRO LEU SER PRO ILE LEU ARG GLN ILE LEU GLN GLN
SEQRES   2 A  313  LEU ALA ALA GLN LEU GLN PHE ARG PRO ASP MET ASP VAL
SEQRES   3 A  313  LYS THR VAL ARG GLU GLN PHE GLU LYS SER SER LEU ILE
SEQRES   4 A  313  LEU VAL LYS MET ALA ASN GLU PRO ILE HIS ARG VAL GLU
SEQRES   5 A  313  ASP ILE THR ILE PRO GLY ARG GLY GLY PRO ILE ARG ALA
SEQRES   6 A  313  ARG VAL TYR ARG PRO ARG ASP GLY GLU ARG LEU PRO ALA
SEQRES   7 A  313  VAL VAL TYR TYR HIS GLY GLY GLY PHE VAL LEU GLY SER
SEQRES   8 A  313  VAL GLU THR HIS ASP HIS VAL CYS ARG ARG LEU ALA ASN
SEQRES   9 A  313  LEU SER GLY ALA VAL VAL VAL SER VAL ASP TYR ARG LEU
SEQRES  10 A  313  ALA PRO GLU HIS LYS PHE PRO ALA ALA VAL GLU ASP ALA
SEQRES  11 A  313  TYR ASP ALA ALA LYS TRP VAL ALA ASP ASN TYR ASP LYS
SEQRES  12 A  313  LEU GLY VAL ASP ASN GLY LYS ILE ALA VAL ALA GLY ASP
SEQRES  13 A  313  SER ALA GLY GLY ASN LEU ALA ALA VAL THR ALA ILE MET
SEQRES  14 A  313  ALA ARG ASP ARG GLY GLU SER PHE VAL LYS TYR GLN VAL
SEQRES  15 A  313  LEU ILE TYR PRO ALA VAL ASN LEU THR GLY SER PRO THR
SEQRES  16 A  313  VAL SER ARG VAL GLU TYR SER GLY PRO GLU TYR VAL ILE
SEQRES  17 A  313  LEU THR ALA ASP LEU MET ALA TRP PHE GLY ARG GLN TYR
SEQRES  18 A  313  PHE SER LYS PRO GLN ASP ALA LEU SER PRO TYR ALA SER
SEQRES  19 A  313  PRO ILE PHE ALA ASP LEU SER ASN LEU PRO PRO ALA LEU
SEQRES  20 A  313  VAL ILE THR ALA GLU TYR ASP PRO LEU ARG ASP GLU GLY
SEQRES  21 A  313  GLU LEU TYR ALA HIS LEU LEU LYS THR ARG GLY VAL ARG
SEQRES  22 A  313  ALA VAL ALA VAL ARG TYR ASN GLY VAL ILE HIS GLY PHE
SEQRES  23 A  313  VAL ASN PHE TYR PRO ILE LEU GLU GLU GLY ARG GLU ALA
SEQRES  24 A  313  VAL SER GLN ILE ALA ALA SER ILE LYS SER MET ALA VAL
SEQRES  25 A  313  ALA
SEQRES   1 B  313  MET PRO LEU SER PRO ILE LEU ARG GLN ILE LEU GLN GLN
SEQRES   2 B  313  LEU ALA ALA GLN LEU GLN PHE ARG PRO ASP MET ASP VAL
SEQRES   3 B  313  LYS THR VAL ARG GLU GLN PHE GLU LYS SER SER LEU ILE
SEQRES   4 B  313  LEU VAL LYS MET ALA ASN GLU PRO ILE HIS ARG VAL GLU
SEQRES   5 B  313  ASP ILE THR ILE PRO GLY ARG GLY GLY PRO ILE ARG ALA
SEQRES   6 B  313  ARG VAL TYR ARG PRO ARG ASP GLY GLU ARG LEU PRO ALA
SEQRES   7 B  313  VAL VAL TYR TYR HIS GLY GLY GLY PHE VAL LEU GLY SER
SEQRES   8 B  313  VAL GLU THR HIS ASP HIS VAL CYS ARG ARG LEU ALA ASN
SEQRES   9 B  313  LEU SER GLY ALA VAL VAL VAL SER VAL ASP TYR ARG LEU
SEQRES  10 B  313  ALA PRO GLU HIS LYS PHE PRO ALA ALA VAL GLU ASP ALA
SEQRES  11 B  313  TYR ASP ALA ALA LYS TRP VAL ALA ASP ASN TYR ASP LYS
SEQRES  12 B  313  LEU GLY VAL ASP ASN GLY LYS ILE ALA VAL ALA GLY ASP
SEQRES  13 B  313  SER ALA GLY GLY ASN LEU ALA ALA VAL THR ALA ILE MET
SEQRES  14 B  313  ALA ARG ASP ARG GLY GLU SER PHE VAL LYS TYR GLN VAL
SEQRES  15 B  313  LEU ILE TYR PRO ALA VAL ASN LEU THR GLY SER PRO THR
SEQRES  16 B  313  VAL SER ARG VAL GLU TYR SER GLY PRO GLU TYR VAL ILE
SEQRES  17 B  313  LEU THR ALA ASP LEU MET ALA TRP PHE GLY ARG GLN TYR
SEQRES  18 B  313  PHE SER LYS PRO GLN ASP ALA LEU SER PRO TYR ALA SER
SEQRES  19 B  313  PRO ILE PHE ALA ASP LEU SER ASN LEU PRO PRO ALA LEU
SEQRES  20 B  313  VAL ILE THR ALA GLU TYR ASP PRO LEU ARG ASP GLU GLY
SEQRES  21 B  313  GLU LEU TYR ALA HIS LEU LEU LYS THR ARG GLY VAL ARG
SEQRES  22 B  313  ALA VAL ALA VAL ARG TYR ASN GLY VAL ILE HIS GLY PHE
SEQRES  23 B  313  VAL ASN PHE TYR PRO ILE LEU GLU GLU GLY ARG GLU ALA
SEQRES  24 B  313  VAL SER GLN ILE ALA ALA SER ILE LYS SER MET ALA VAL
SEQRES  25 B  313  ALA
SEQRES   1 C  313  MET PRO LEU SER PRO ILE LEU ARG GLN ILE LEU GLN GLN
SEQRES   2 C  313  LEU ALA ALA GLN LEU GLN PHE ARG PRO ASP MET ASP VAL
SEQRES   3 C  313  LYS THR VAL ARG GLU GLN PHE GLU LYS SER SER LEU ILE
SEQRES   4 C  313  LEU VAL LYS MET ALA ASN GLU PRO ILE HIS ARG VAL GLU
SEQRES   5 C  313  ASP ILE THR ILE PRO GLY ARG GLY GLY PRO ILE ARG ALA
SEQRES   6 C  313  ARG VAL TYR ARG PRO ARG ASP GLY GLU ARG LEU PRO ALA
SEQRES   7 C  313  VAL VAL TYR TYR HIS GLY GLY GLY PHE VAL LEU GLY SER
SEQRES   8 C  313  VAL GLU THR HIS ASP HIS VAL CYS ARG ARG LEU ALA ASN
SEQRES   9 C  313  LEU SER GLY ALA VAL VAL VAL SER VAL ASP TYR ARG LEU
SEQRES  10 C  313  ALA PRO GLU HIS LYS PHE PRO ALA ALA VAL GLU ASP ALA
SEQRES  11 C  313  TYR ASP ALA ALA LYS TRP VAL ALA ASP ASN TYR ASP LYS
SEQRES  12 C  313  LEU GLY VAL ASP ASN GLY LYS ILE ALA VAL ALA GLY ASP
SEQRES  13 C  313  SER ALA GLY GLY ASN LEU ALA ALA VAL THR ALA ILE MET
SEQRES  14 C  313  ALA ARG ASP ARG GLY GLU SER PHE VAL LYS TYR GLN VAL
SEQRES  15 C  313  LEU ILE TYR PRO ALA VAL ASN LEU THR GLY SER PRO THR
SEQRES  16 C  313  VAL SER ARG VAL GLU TYR SER GLY PRO GLU TYR VAL ILE
SEQRES  17 C  313  LEU THR ALA ASP LEU MET ALA TRP PHE GLY ARG GLN TYR
SEQRES  18 C  313  PHE SER LYS PRO GLN ASP ALA LEU SER PRO TYR ALA SER
SEQRES  19 C  313  PRO ILE PHE ALA ASP LEU SER ASN LEU PRO PRO ALA LEU
SEQRES  20 C  313  VAL ILE THR ALA GLU TYR ASP PRO LEU ARG ASP GLU GLY
SEQRES  21 C  313  GLU LEU TYR ALA HIS LEU LEU LYS THR ARG GLY VAL ARG
SEQRES  22 C  313  ALA VAL ALA VAL ARG TYR ASN GLY VAL ILE HIS GLY PHE
SEQRES  23 C  313  VAL ASN PHE TYR PRO ILE LEU GLU GLU GLY ARG GLU ALA
SEQRES  24 C  313  VAL SER GLN ILE ALA ALA SER ILE LYS SER MET ALA VAL
SEQRES  25 C  313  ALA
SEQRES   1 D  313  MET PRO LEU SER PRO ILE LEU ARG GLN ILE LEU GLN GLN
SEQRES   2 D  313  LEU ALA ALA GLN LEU GLN PHE ARG PRO ASP MET ASP VAL
SEQRES   3 D  313  LYS THR VAL ARG GLU GLN PHE GLU LYS SER SER LEU ILE
SEQRES   4 D  313  LEU VAL LYS MET ALA ASN GLU PRO ILE HIS ARG VAL GLU
SEQRES   5 D  313  ASP ILE THR ILE PRO GLY ARG GLY GLY PRO ILE ARG ALA
SEQRES   6 D  313  ARG VAL TYR ARG PRO ARG ASP GLY GLU ARG LEU PRO ALA
SEQRES   7 D  313  VAL VAL TYR TYR HIS GLY GLY GLY PHE VAL LEU GLY SER
SEQRES   8 D  313  VAL GLU THR HIS ASP HIS VAL CYS ARG ARG LEU ALA ASN
SEQRES   9 D  313  LEU SER GLY ALA VAL VAL VAL SER VAL ASP TYR ARG LEU
SEQRES  10 D  313  ALA PRO GLU HIS LYS PHE PRO ALA ALA VAL GLU ASP ALA
SEQRES  11 D  313  TYR ASP ALA ALA LYS TRP VAL ALA ASP ASN TYR ASP LYS
SEQRES  12 D  313  LEU GLY VAL ASP ASN GLY LYS ILE ALA VAL ALA GLY ASP
SEQRES  13 D  313  SER ALA GLY GLY ASN LEU ALA ALA VAL THR ALA ILE MET
SEQRES  14 D  313  ALA ARG ASP ARG GLY GLU SER PHE VAL LYS TYR GLN VAL
SEQRES  15 D  313  LEU ILE TYR PRO ALA VAL ASN LEU THR GLY SER PRO THR
SEQRES  16 D  313  VAL SER ARG VAL GLU TYR SER GLY PRO GLU TYR VAL ILE
SEQRES  17 D  313  LEU THR ALA ASP LEU MET ALA TRP PHE GLY ARG GLN TYR
SEQRES  18 D  313  PHE SER LYS PRO GLN ASP ALA LEU SER PRO TYR ALA SER
SEQRES  19 D  313  PRO ILE PHE ALA ASP LEU SER ASN LEU PRO PRO ALA LEU
SEQRES  20 D  313  VAL ILE THR ALA GLU TYR ASP PRO LEU ARG ASP GLU GLY
SEQRES  21 D  313  GLU LEU TYR ALA HIS LEU LEU LYS THR ARG GLY VAL ARG
SEQRES  22 D  313  ALA VAL ALA VAL ARG TYR ASN GLY VAL ILE HIS GLY PHE
SEQRES  23 D  313  VAL ASN PHE TYR PRO ILE LEU GLU GLU GLY ARG GLU ALA
SEQRES  24 D  313  VAL SER GLN ILE ALA ALA SER ILE LYS SER MET ALA VAL
SEQRES  25 D  313  ALA
HET    SO4  A1314       5
HETNAM     SO4 SULFATE ION
FORMUL   5  SO4    O4 S 2-
FORMUL   6  HOH   *368(H2 O)
HELIX    1   1 SER A    4  GLN A   12  1                                   9
HELIX    2   2 ASP A   25  ASN A   45  1                                  21
HELIX    3   3 HIS A   95  GLY A  107  1                                  13
HELIX    4   4 PRO A  124  ASN A  140  1                                  17
HELIX    5   5 ASN A  140  GLY A  145  1                                   6
HELIX    6   6 SER A  157  ARG A  173  1                                  17
HELIX    7   7 THR A  195  TYR A  201  1                                   7
HELIX    8   8 GLY A  203  VAL A  207  5                                   5
HELIX    9   9 THR A  210  PHE A  222  1                                  13
HELIX   10  10 LYS A  224  SER A  230  5                                   7
HELIX   11  11 SER A  234  ALA A  238  5                                   5
HELIX   12  12 LEU A  256  ARG A  270  1                                  15
HELIX   13  13 GLY A  285  TYR A  290  5                                   6
HELIX   14  14 LEU A  293  MET A  310  1                                  18
HELIX   15  15 SER B    4  GLN B   12  1                                   9
HELIX   16  16 ASP B   25  ASN B   45  1                                  21
HELIX   17  17 HIS B   95  GLY B  107  1                                  13
HELIX   18  18 PRO B  124  ASN B  140  1                                  17
HELIX   19  19 ASN B  140  GLY B  145  1                                   6
HELIX   20  20 SER B  157  ARG B  173  1                                  17
HELIX   21  21 THR B  195  TYR B  201  1                                   7
HELIX   22  22 GLY B  203  VAL B  207  5                                   5
HELIX   23  23 THR B  210  PHE B  222  1                                  13
HELIX   24  24 LYS B  224  SER B  230  5                                   7
HELIX   25  25 SER B  234  ALA B  238  5                                   5
HELIX   26  26 LEU B  256  ARG B  270  1                                  15
HELIX   27  27 GLY B  285  TYR B  290  5                                   6
HELIX   28  28 LEU B  293  MET B  310  1                                  18
HELIX   29  29 SER C    4  ALA C   16  1                                  13
HELIX   30  30 ASP C   25  ASN C   45  1                                  21
HELIX   31  31 VAL C   92  THR C   94  5                                   3
HELIX   32  32 HIS C   95  GLY C  107  1                                  13
HELIX   33  33 PRO C  124  ASN C  140  1                                  17
HELIX   34  34 ASN C  140  GLY C  145  1                                   6
HELIX   35  35 SER C  157  ARG C  173  1                                  17
HELIX   36  36 THR C  195  TYR C  201  1                                   7
HELIX   37  37 GLY C  203  VAL C  207  5                                   5
HELIX   38  38 THR C  210  PHE C  222  1                                  13
HELIX   39  39 LYS C  224  SER C  230  5                                   7
HELIX   40  40 SER C  234  ALA C  238  5                                   5
HELIX   41  41 LEU C  256  ARG C  270  1                                  15
HELIX   42  42 GLY C  285  TYR C  290  5                                   6
HELIX   43  43 LEU C  293  MET C  310  1                                  18
HELIX   44  44 SER D    4  GLN D   13  1                                  10
HELIX   45  45 ASP D   25  ASN D   45  1                                  21
HELIX   46  46 VAL D   92  THR D   94  5                                   3
HELIX   47  47 HIS D   95  GLY D  107  1                                  13
HELIX   48  48 PRO D  124  ASN D  140  1                                  17
HELIX   49  49 ASN D  140  GLY D  145  1                                   6
HELIX   50  50 SER D  157  ARG D  173  1                                  17
HELIX   51  51 THR D  195  TYR D  201  1                                   7
HELIX   52  52 GLY D  203  VAL D  207  5                                   5
HELIX   53  53 THR D  210  PHE D  222  1                                  13
HELIX   54  54 LYS D  224  SER D  230  5                                   7
HELIX   55  55 SER D  234  ALA D  238  5                                   5
HELIX   56  56 LEU D  256  ARG D  270  1                                  15
HELIX   57  57 GLY D  285  TYR D  290  5                                   6
HELIX   58  58 LEU D  293  MET D  310  1                                  18
SHEET    1  AA16 ARG A  50  GLY A  58  0
SHEET    2  AA16 GLY A  61  ARG A  69 -1  O  GLY A  61   N  GLY A  58
SHEET    3  AA16 VAL A 109  ASP A 114 -1  O  VAL A 110   N  TYR A  68
SHEET    4  AA16 ALA A  78  TYR A  82  1  O  VAL A  79   N  VAL A 111
SHEET    5  AA16 ILE A 151  ASP A 156  1  O  ALA A 152   N  VAL A  80
SHEET    6  AA16 VAL A 178  ILE A 184  1  N  LYS A 179   O  ILE A 151
SHEET    7  AA16 ALA A 246  TYR A 253  1  O  LEU A 247   N  LEU A 183
SHEET    8  AA16 ALA A 274  ILE A 283  1  O  VAL A 275   N  VAL A 248
SHEET    9  AA16 ALA B 274  ILE B 283 -1  O  ALA B 276   N  ASN A 280
SHEET   10  AA16 ALA B 246  TYR B 253  1  O  ALA B 246   N  VAL B 275
SHEET   11  AA16 TYR B 180  ILE B 184  1  O  GLN B 181   N  LEU B 247
SHEET   12  AA16 VAL B 146  ASP B 156  1  O  VAL B 153   N  VAL B 182
SHEET   13  AA16 LEU B  76  TYR B  82  1  O  LEU B  76   N  ASP B 147
SHEET   14  AA16 VAL B 109  ASP B 114  1  O  VAL B 109   N  VAL B  79
SHEET   15  AA16 GLY B  61  ARG B  69 -1  O  ARG B  64   N  ASP B 114
SHEET   16  AA16 ARG B  50  GLY B  58 -1  O  ARG B  50   N  ARG B  69
SHEET    1  CA16 ARG C  50  GLY C  58  0
SHEET    2  CA16 GLY C  61  ARG C  69 -1  O  GLY C  61   N  GLY C  58
SHEET    3  CA16 VAL C 109  ASP C 114 -1  O  VAL C 110   N  TYR C  68
SHEET    4  CA16 LEU C  76  TYR C  82  1  O  PRO C  77   N  VAL C 109
SHEET    5  CA16 VAL C 146  ASP C 156  1  N  ASP C 147   O  LEU C  76
SHEET    6  CA16 VAL C 178  ILE C 184  1  N  LYS C 179   O  ILE C 151
SHEET    7  CA16 ALA C 246  TYR C 253  1  O  LEU C 247   N  LEU C 183
SHEET    8  CA16 ALA C 274  ILE C 283  1  O  VAL C 275   N  VAL C 248
SHEET    9  CA16 ALA D 274  ILE D 283 -1  O  ALA D 276   N  ASN C 280
SHEET   10  CA16 ALA D 246  TYR D 253  1  O  ALA D 246   N  VAL D 275
SHEET   11  CA16 TYR D 180  ILE D 184  1  O  GLN D 181   N  LEU D 247
SHEET   12  CA16 VAL D 146  ASP D 156  1  O  VAL D 153   N  VAL D 182
SHEET   13  CA16 LEU D  76  TYR D  82  1  O  LEU D  76   N  ASP D 147
SHEET   14  CA16 VAL D 109  ASP D 114  1  O  VAL D 109   N  VAL D  79
SHEET   15  CA16 GLY D  61  ARG D  69 -1  O  ARG D  64   N  ASP D 114
SHEET   16  CA16 ARG D  50  GLY D  58 -1  O  ARG D  50   N  ARG D  69
CISPEP   1 ALA A  118    PRO A  119          0         4.69
CISPEP   2 PHE A  123    PRO A  124          0         6.69
CISPEP   3 ALA B  118    PRO B  119          0         1.11
CISPEP   4 PHE B  123    PRO B  124          0         7.85
CISPEP   5 ALA C  118    PRO C  119          0         3.83
CISPEP   6 PHE C  123    PRO C  124          0         5.22
CISPEP   7 ALA D  118    PRO D  119          0         5.77
CISPEP   8 PHE D  123    PRO D  124          0        10.21
SITE     1 AC1  5 ASP A 139  ASN A 140  TYR A 141  ASP A 142
SITE     2 AC1  5 LYS A 143
SITE     1 ASA  3 SER A 157  HIS A 284  ASP A 254
SITE     1 ASB  3 SER B 157  HIS B 284  ASP B 254
SITE     1 ASC  3 SER C 157  HIS C 284  ASP C 254
SITE     1 ASD  3 SER D 157  HIS D 284  ASP D 254
CRYST1   57.282   72.335  141.873  90.00  90.19  90.00 P 1 21 1      8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.017457  0.000000  0.000058        0.00000
SCALE2      0.000000  0.013825  0.000000        0.00000
SCALE3      0.000000  0.000000  0.007049        0.00000
MTRIX1   1 -0.999790  0.001800 -0.020320       29.56792    1
MTRIX2   1  0.007480 -0.894290 -0.447420       56.28368    1
MTRIX3   1 -0.018980 -0.447480  0.894090       13.51402    1
MTRIX1   2  0.998730 -0.044320 -0.023980        2.20997    1
MTRIX2   2 -0.044070 -0.998970  0.010710       42.67968    1
MTRIX3   2 -0.024430 -0.009640 -0.999660       71.47411    1
MTRIX1   3 -0.999550  0.029840  0.001030       28.20140    1
MTRIX2   3  0.027270  0.898150  0.438850      -13.72702    1
MTRIX3   3  0.012170  0.438680 -0.898560       57.84884    1
MTRIX1   4 -0.998200  0.056630 -0.019830       28.74554    1
MTRIX2   4  0.041340  0.888680  0.456670      -14.69877    1
MTRIX3   4  0.043480  0.455020 -0.889420       56.58555    1
MTRIX1   5  0.999410 -0.033600  0.006500        0.47794    1
MTRIX2   5 -0.033540 -0.999390 -0.009510       43.63300    1
MTRIX3   5  0.006820  0.009290 -0.999930       70.62668    1
MTRIX1   6 -0.999620  0.014850  0.023190       28.12387    1
MTRIX2   6 -0.023670 -0.893520 -0.448390       56.49620    1
MTRIX3   6  0.014060 -0.448770  0.893540       13.09818    1
TER    2407      ALA A 313
TER    4826      ALA B 313
TER    7186      ALA C 313
TER    9584      ALA D 313
MASTER      470    0    1   58   32    0    6   24 9953    4    5  100
END