longtext: 3A2L-pdb

content
HEADER    HYDROLASE                               23-MAY-09   3A2L
TITLE     CRYSTAL STRUCTURE OF DBJA (MUTANT DBJA DELTA)
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: HALOALKANE DEHALOGENASE;
COMPND   3 CHAIN: A, B;
COMPND   4 EC: 3.8.1.5;
COMPND   5 ENGINEERED: YES;
COMPND   6 MUTATION: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: BRADYRHIZOBIUM JAPONICUM;
SOURCE   3 ORGANISM_TAXID: 375;
SOURCE   4 STRAIN: USDA110;
SOURCE   5 GENE: DBJA;
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PYBJA2DEL
KEYWDS    A/B-HYDROLASE, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    Y.SATO,T.SENDA
REVDAT   2   27-OCT-10 3A2L    1       JRNL
REVDAT   1   26-MAY-10 3A2L    0
JRNL        AUTH   Z.PROKOP,Y.SATO,J.BREZOVSKY,T.MOZGA,R.CHALOUPKOVA,
JRNL        AUTH 2 T.KOUDELAKOVA,P.JERABEK,V.STEPANKOVA,R.NATSUME,
JRNL        AUTH 3 J.G.VAN LEEUWEN,D.B.JANSSEN,J.FLORIAN,Y.NAGATA,T.SENDA,
JRNL        AUTH 4 J.DAMBORSKY
JRNL        TITL   ENANTIOSELECTIVITY OF HALOALKANE DEHALOGENASES AND ITS
JRNL        TITL 2 MODULATION BY SURFACE LOOP ENGINEERING
JRNL        REF    ANGEW.CHEM.INT.ED.ENGL.       V.  49  6111 2010
JRNL        REFN                   ISSN 1433-7851
JRNL        PMID   20645368
JRNL        DOI    10.1002/ANIE.201001753
REMARK   2
REMARK   2 RESOLUTION.    1.78 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.2.0005
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.78
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 43.19
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.8
REMARK   3   NUMBER OF REFLECTIONS             : 57853
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.171
REMARK   3   R VALUE            (WORKING SET) : 0.169
REMARK   3   FREE R VALUE                     : 0.205
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.100
REMARK   3   FREE R VALUE TEST SET COUNT      : 3088
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 1.78
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 1.83
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 3912
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 92.15
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2280
REMARK   3   BIN FREE R VALUE SET COUNT          : 208
REMARK   3   BIN FREE R VALUE                    : 0.3030
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 4543
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 54
REMARK   3   SOLVENT ATOMS            : 379
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 20.23
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : 0.00000
REMARK   3    B22 (A**2) : 0.00000
REMARK   3    B33 (A**2) : 0.00000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.112
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.110
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.069
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 2.149
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.962
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.940
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  4729 ; 0.013 ; 0.022
REMARK   3   BOND LENGTHS OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES):  6443 ; 1.403 ; 1.967
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):   582 ; 5.145 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   218 ;32.860 ;21.835
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):   691 ;13.410 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    49 ;19.290 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):   697 ; 0.098 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  3693 ; 0.005 ; 0.020
REMARK   3   GENERAL PLANES OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  2247 ; 0.201 ; 0.200
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  3245 ; 0.311 ; 0.200
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):   359 ; 0.118 ; 0.200
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):    33 ; 0.191 ; 0.200
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):    24 ; 0.136 ; 0.200
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  2988 ; 0.885 ; 1.500
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  4674 ; 1.421 ; 2.000
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  1952 ; 2.330 ; 3.000
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  1769 ; 3.843 ; 4.500
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING
REMARK   3  POSITIONS
REMARK   4
REMARK   4 3A2L COMPLIES WITH FORMAT V. 3.20, 01-DEC-08
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 26-MAY-09.
REMARK 100 THE RCSB ID CODE IS RCSB028732.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 25-NOV-05
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 7.9
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : PHOTON FACTORY
REMARK 200  BEAMLINE                       : AR-NW12A
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.978
REMARK 200  MONOCHROMATOR                  : SI
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 210
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000
REMARK 200  DATA SCALING SOFTWARE          : HKL
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 60942
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.780
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.6
REMARK 200  DATA REDUNDANCY                : 3.500
REMARK 200  R MERGE                    (I) : 0.07200
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 10.8000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.78
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.84
REMARK 200  COMPLETENESS FOR SHELL     (%) : 92.4
REMARK 200  DATA REDUNDANCY IN SHELL       : 2.70
REMARK 200  R MERGE FOR SHELL          (I) : 0.34900
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: NULL
REMARK 200 STARTING MODEL: PDB ENTRY 3A1O
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 48.05
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.37
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: PEG 4000, PH 7.9, VAPOR DIFFUSION,
REMARK 280  HANGING DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 1 2 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y,-Z
REMARK 290       3555   X+1/2,Y+1/2,Z
REMARK 290       4555   -X+1/2,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   3  1.000000  0.000000  0.000000       62.77350
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       24.32600
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000       62.77350
REMARK 290   SMTRY2   4  0.000000  1.000000  0.000000       24.32600
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 3240 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 21190 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -36.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A     1
REMARK 465     SER A     2
REMARK 465     LYS A     3
REMARK 465     PRO A     4
REMARK 465     ILE A     5
REMARK 465     GLU A     6
REMARK 465     ARG A   305
REMARK 465     PRO A   306
REMARK 465     GLN A   307
REMARK 465     LEU A   308
REMARK 465     ALA A   309
REMARK 465     ALA A   310
REMARK 465     HIS A   311
REMARK 465     HIS A   312
REMARK 465     HIS A   313
REMARK 465     HIS A   314
REMARK 465     HIS A   315
REMARK 465     HIS A   316
REMARK 465     MET B     1
REMARK 465     SER B     2
REMARK 465     LYS B     3
REMARK 465     PRO B     4
REMARK 465     ILE B     5
REMARK 465     PRO B   306
REMARK 465     GLN B   307
REMARK 465     LEU B   308
REMARK 465     ALA B   309
REMARK 465     ALA B   310
REMARK 465     HIS B   311
REMARK 465     HIS B   312
REMARK 465     HIS B   313
REMARK 465     HIS B   314
REMARK 465     HIS B   315
REMARK 465     HIS B   316
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     VAL B 304    O
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    ARG A 207   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.2 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    SER A  17     -152.56   -121.53
REMARK 500    PRO A  39       55.71   -105.08
REMARK 500    THR A  40     -158.20   -105.21
REMARK 500    ASP A 103     -130.59     56.24
REMARK 500    HIS A 139     -175.86     62.78
REMARK 500    ALA A 253      -76.12   -141.85
REMARK 500    LEU A 279     -112.14   -115.36
REMARK 500    SER B  17     -150.60   -120.25
REMARK 500    PRO B  39       52.49   -103.28
REMARK 500    THR B  40     -160.13   -103.57
REMARK 500    ASP B 103     -134.78     59.56
REMARK 500    HIS B 139      177.38     60.84
REMARK 500    ARG B 179      -51.39   -125.52
REMARK 500    ALA B 253      -75.22   -136.51
REMARK 500    LEU B 279     -113.46   -119.30
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH A 894        DISTANCE =  5.10 ANGSTROMS
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL A 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SUC A 2381
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL A 501
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 402
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SUC B 2380
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 3A1O   RELATED DB: PDB
REMARK 900 HIS-DBJA
REMARK 900 RELATED ID: 3A2M   RELATED DB: PDB
REMARK 900 DBJA (WILD TYPE, TYPE I)
REMARK 900 RELATED ID: 3M2N   RELATED DB: PDB
REMARK 900 DBJA (WILD TYPE, TYPE II)
DBREF  3A2L A    1   310  UNP    P59337   DHAA_BRAJA       1    310
DBREF  3A2L B    1   310  UNP    P59337   DHAA_BRAJA       1    310
SEQADV 3A2L     A       UNP  P59337    HIS   140 DELETION
SEQADV 3A2L     A       UNP  P59337    THR   141 DELETION
SEQADV 3A2L     A       UNP  P59337    GLU   142 DELETION
SEQADV 3A2L     A       UNP  P59337    VAL   143 DELETION
SEQADV 3A2L     A       UNP  P59337    ALA   144 DELETION
SEQADV 3A2L     A       UNP  P59337    GLU   145 DELETION
SEQADV 3A2L     A       UNP  P59337    GLU   146 DELETION
SEQADV 3A2L HIS A  311  UNP  P59337              EXPRESSION TAG
SEQADV 3A2L HIS A  312  UNP  P59337              EXPRESSION TAG
SEQADV 3A2L HIS A  313  UNP  P59337              EXPRESSION TAG
SEQADV 3A2L HIS A  314  UNP  P59337              EXPRESSION TAG
SEQADV 3A2L HIS A  315  UNP  P59337              EXPRESSION TAG
SEQADV 3A2L HIS A  316  UNP  P59337              EXPRESSION TAG
SEQADV 3A2L     B       UNP  P59337    HIS   140 DELETION
SEQADV 3A2L     B       UNP  P59337    THR   141 DELETION
SEQADV 3A2L     B       UNP  P59337    GLU   142 DELETION
SEQADV 3A2L     B       UNP  P59337    VAL   143 DELETION
SEQADV 3A2L     B       UNP  P59337    ALA   144 DELETION
SEQADV 3A2L     B       UNP  P59337    GLU   145 DELETION
SEQADV 3A2L     B       UNP  P59337    GLU   146 DELETION
SEQADV 3A2L HIS B  311  UNP  P59337              EXPRESSION TAG
SEQADV 3A2L HIS B  312  UNP  P59337              EXPRESSION TAG
SEQADV 3A2L HIS B  313  UNP  P59337              EXPRESSION TAG
SEQADV 3A2L HIS B  314  UNP  P59337              EXPRESSION TAG
SEQADV 3A2L HIS B  315  UNP  P59337              EXPRESSION TAG
SEQADV 3A2L HIS B  316  UNP  P59337              EXPRESSION TAG
SEQRES   1 A  309  MET SER LYS PRO ILE GLU ILE GLU ILE ARG ARG ALA PRO
SEQRES   2 A  309  VAL LEU GLY SER SER MET ALA TYR ARG GLU THR GLY ALA
SEQRES   3 A  309  GLN ASP ALA PRO VAL VAL LEU PHE LEU HIS GLY ASN PRO
SEQRES   4 A  309  THR SER SER HIS ILE TRP ARG ASN ILE LEU PRO LEU VAL
SEQRES   5 A  309  SER PRO VAL ALA HIS CYS ILE ALA PRO ASP LEU ILE GLY
SEQRES   6 A  309  PHE GLY GLN SER GLY LYS PRO ASP ILE ALA TYR ARG PHE
SEQRES   7 A  309  PHE ASP HIS VAL ARG TYR LEU ASP ALA PHE ILE GLU GLN
SEQRES   8 A  309  ARG GLY VAL THR SER ALA TYR LEU VAL ALA GLN ASP TRP
SEQRES   9 A  309  GLY THR ALA LEU ALA PHE HIS LEU ALA ALA ARG ARG PRO
SEQRES  10 A  309  ASP PHE VAL ARG GLY LEU ALA PHE MET GLU PHE ILE ARG
SEQRES  11 A  309  PRO MET PRO THR TRP GLN ASP PHE HIS GLN ASP HIS ALA
SEQRES  12 A  309  GLU ALA ALA ARG ALA VAL PHE ARG LYS PHE ARG THR PRO
SEQRES  13 A  309  GLY GLU GLY GLU ALA MET ILE LEU GLU ALA ASN ALA PHE
SEQRES  14 A  309  VAL GLU ARG VAL LEU PRO GLY GLY ILE VAL ARG LYS LEU
SEQRES  15 A  309  GLY ASP GLU GLU MET ALA PRO TYR ARG THR PRO PHE PRO
SEQRES  16 A  309  THR PRO GLU SER ARG ARG PRO VAL LEU ALA PHE PRO ARG
SEQRES  17 A  309  GLU LEU PRO ILE ALA GLY GLU PRO ALA ASP VAL TYR GLU
SEQRES  18 A  309  ALA LEU GLN SER ALA HIS ALA ALA LEU ALA ALA SER SER
SEQRES  19 A  309  TYR PRO LYS LEU LEU PHE THR GLY GLU PRO GLY ALA LEU
SEQRES  20 A  309  VAL SER PRO GLU PHE ALA GLU ARG PHE ALA ALA SER LEU
SEQRES  21 A  309  THR ARG CYS ALA LEU ILE ARG LEU GLY ALA GLY LEU HIS
SEQRES  22 A  309  TYR LEU GLN GLU ASP HIS ALA ASP ALA ILE GLY ARG SER
SEQRES  23 A  309  VAL ALA GLY TRP ILE ALA GLY ILE GLU ALA VAL ARG PRO
SEQRES  24 A  309  GLN LEU ALA ALA HIS HIS HIS HIS HIS HIS
SEQRES   1 B  309  MET SER LYS PRO ILE GLU ILE GLU ILE ARG ARG ALA PRO
SEQRES   2 B  309  VAL LEU GLY SER SER MET ALA TYR ARG GLU THR GLY ALA
SEQRES   3 B  309  GLN ASP ALA PRO VAL VAL LEU PHE LEU HIS GLY ASN PRO
SEQRES   4 B  309  THR SER SER HIS ILE TRP ARG ASN ILE LEU PRO LEU VAL
SEQRES   5 B  309  SER PRO VAL ALA HIS CYS ILE ALA PRO ASP LEU ILE GLY
SEQRES   6 B  309  PHE GLY GLN SER GLY LYS PRO ASP ILE ALA TYR ARG PHE
SEQRES   7 B  309  PHE ASP HIS VAL ARG TYR LEU ASP ALA PHE ILE GLU GLN
SEQRES   8 B  309  ARG GLY VAL THR SER ALA TYR LEU VAL ALA GLN ASP TRP
SEQRES   9 B  309  GLY THR ALA LEU ALA PHE HIS LEU ALA ALA ARG ARG PRO
SEQRES  10 B  309  ASP PHE VAL ARG GLY LEU ALA PHE MET GLU PHE ILE ARG
SEQRES  11 B  309  PRO MET PRO THR TRP GLN ASP PHE HIS GLN ASP HIS ALA
SEQRES  12 B  309  GLU ALA ALA ARG ALA VAL PHE ARG LYS PHE ARG THR PRO
SEQRES  13 B  309  GLY GLU GLY GLU ALA MET ILE LEU GLU ALA ASN ALA PHE
SEQRES  14 B  309  VAL GLU ARG VAL LEU PRO GLY GLY ILE VAL ARG LYS LEU
SEQRES  15 B  309  GLY ASP GLU GLU MET ALA PRO TYR ARG THR PRO PHE PRO
SEQRES  16 B  309  THR PRO GLU SER ARG ARG PRO VAL LEU ALA PHE PRO ARG
SEQRES  17 B  309  GLU LEU PRO ILE ALA GLY GLU PRO ALA ASP VAL TYR GLU
SEQRES  18 B  309  ALA LEU GLN SER ALA HIS ALA ALA LEU ALA ALA SER SER
SEQRES  19 B  309  TYR PRO LYS LEU LEU PHE THR GLY GLU PRO GLY ALA LEU
SEQRES  20 B  309  VAL SER PRO GLU PHE ALA GLU ARG PHE ALA ALA SER LEU
SEQRES  21 B  309  THR ARG CYS ALA LEU ILE ARG LEU GLY ALA GLY LEU HIS
SEQRES  22 B  309  TYR LEU GLN GLU ASP HIS ALA ASP ALA ILE GLY ARG SER
SEQRES  23 B  309  VAL ALA GLY TRP ILE ALA GLY ILE GLU ALA VAL ARG PRO
SEQRES  24 B  309  GLN LEU ALA ALA HIS HIS HIS HIS HIS HIS
HET     CL  A 401       1
HET    SUC  A2381      23
HET    GOL  A 501       6
HET     CL  B 402       1
HET    SUC  B2380      23
HETNAM      CL CHLORIDE ION
HETNAM     SUC SUCROSE
HETNAM     GOL GLYCEROL
HETSYN     GOL GLYCERIN; PROPANE-1,2,3-TRIOL
FORMUL   3   CL    2(CL 1-)
FORMUL   4  SUC    2(C12 H22 O11)
FORMUL   5  GOL    C3 H8 O3
FORMUL   8  HOH   *379(H2 O)
HELIX    1   1 SER A   41  ARG A   46  5                                   6
HELIX    2   2 ILE A   48  SER A   53  1                                   6
HELIX    3   3 ARG A   77  GLY A   93  1                                  17
HELIX    4   4 ASP A  103  ARG A  116  1                                  14
HELIX    5   5 THR A  134  PHE A  138  5                                   5
HELIX    6   6 GLN A  147  HIS A  149  5                                   3
HELIX    7   7 ALA A  150  ARG A  161  1                                  12
HELIX    8   8 GLY A  164  LEU A  171  1                                   8
HELIX    9   9 ASN A  174  ARG A  179  1                                   6
HELIX   10  10 ARG A  179  GLY A  184  1                                   6
HELIX   11  11 GLY A  190  THR A  199  1                                  10
HELIX   12  12 PRO A  204  SER A  206  5                                   3
HELIX   13  13 ARG A  207  LEU A  217  1                                  11
HELIX   14  14 PRO A  223  SER A  240  1                                  18
HELIX   15  15 SER A  256  SER A  266  1                                  11
HELIX   16  16 TYR A  281  VAL A  304  1                                  24
HELIX   17  17 SER B   41  ARG B   46  5                                   6
HELIX   18  18 ILE B   48  SER B   53  1                                   6
HELIX   19  19 ARG B   77  ARG B   92  1                                  16
HELIX   20  20 ASP B  103  ARG B  116  1                                  14
HELIX   21  21 THR B  134  PHE B  138  5                                   5
HELIX   22  22 GLN B  147  HIS B  149  5                                   3
HELIX   23  23 ALA B  150  ARG B  161  1                                  12
HELIX   24  24 GLY B  164  LEU B  171  1                                   8
HELIX   25  25 ASN B  174  ARG B  179  1                                   6
HELIX   26  26 ARG B  179  GLY B  184  1                                   6
HELIX   27  27 GLY B  190  THR B  199  1                                  10
HELIX   28  28 PRO B  204  SER B  206  5                                   3
HELIX   29  29 ARG B  207  LEU B  217  1                                  11
HELIX   30  30 PRO B  223  SER B  240  1                                  18
HELIX   31  31 SER B  256  LEU B  267  1                                  12
HELIX   32  32 TYR B  281  VAL B  304  1                                  24
SHEET    1   A 8 ILE A   9  VAL A  14  0
SHEET    2   A 8 SER A  17  THR A  24 -1  O  TYR A  21   N  ARG A  10
SHEET    3   A 8 HIS A  57  PRO A  61 -1  O  CYS A  58   N  THR A  24
SHEET    4   A 8 VAL A  31  LEU A  35  1  N  VAL A  32   O  ILE A  59
SHEET    5   A 8 ALA A  97  GLN A 102  1  O  TYR A  98   N  LEU A  33
SHEET    6   A 8 VAL A 120  MET A 126  1  O  ALA A 124   N  LEU A  99
SHEET    7   A 8 LYS A 244  PRO A 251  1  O  LEU A 245   N  PHE A 125
SHEET    8   A 8 CYS A 270  GLY A 278  1  O  ALA A 271   N  LEU A 246
SHEET    1   B 8 GLU B   8  VAL B  14  0
SHEET    2   B 8 SER B  17  THR B  24 -1  O  TYR B  21   N  ARG B  10
SHEET    3   B 8 HIS B  57  PRO B  61 -1  O  CYS B  58   N  THR B  24
SHEET    4   B 8 VAL B  31  LEU B  35  1  N  VAL B  32   O  ILE B  59
SHEET    5   B 8 ALA B  97  GLN B 102  1  O  TYR B  98   N  LEU B  33
SHEET    6   B 8 VAL B 120  MET B 126  1  O  ALA B 124   N  LEU B  99
SHEET    7   B 8 LYS B 244  PRO B 251  1  O  LEU B 245   N  PHE B 125
SHEET    8   B 8 CYS B 270  GLY B 278  1  O  ILE B 273   N  LEU B 246
CISPEP   1 ASN A   38    PRO A   39          0        -7.85
CISPEP   2 GLU A  222    PRO A  223          0        -6.29
CISPEP   3 GLU A  250    PRO A  251          0         5.04
CISPEP   4 ASN B   38    PRO B   39          0        -6.30
CISPEP   5 GLU B  222    PRO B  223          0        -4.45
CISPEP   6 GLU B  250    PRO B  251          0         2.77
SITE     1 AC1  4 ASN A  38  TRP A 104  PHE A 213  PRO A 214
SITE     1 AC2 10 PRO A  30  VAL A  55  ALA A 299  GLU A 302
SITE     2 AC2 10 HOH A 719  HOH A 766  HOH A 851  ARG B 269
SITE     3 AC2 10 CYS B 270  HOH B 658
SITE     1 AC3  5 CYS A 270  HOH A 853  HOH A 962  HOH B 644
SITE     2 AC3  5 SUC B2380
SITE     1 AC4  4 ASN B  38  TRP B 104  PRO B 214  HOH B 816
SITE     1 AC5 13 ARG A 269  CYS A 270  ALA A 271  GOL A 501
SITE     2 AC5 13 HOH A 677  PRO B  30  VAL B  55  ALA B 299
SITE     3 AC5 13 GLU B 302  HOH B 635  HOH B 644  HOH B 689
SITE     4 AC5 13 HOH B 829
CRYST1  125.547   48.652  106.816  90.00  97.39  90.00 C 1 2 1       8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.007965  0.000000  0.001034        0.00000
SCALE2      0.000000  0.020554  0.000000        0.00000
SCALE3      0.000000  0.000000  0.009440        0.00000
TER    2263      VAL A 304
TER    4545      ARG B 305
MASTER      374    0    5   32   16    0   11    6 4976    2   52   48
END