longtext: 3AIK-pdb

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HEADER    HYDROLASE                               16-MAY-10   3AIK
TITLE     CRYSTAL STRUCTURE OF A HSL-LIKE CARBOXYLESTERASE FROM SULFOLOBUS
TITLE    2 TOKODAII
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: 303AA LONG HYPOTHETICAL ESTERASE;
COMPND   3 CHAIN: A, B, C, D;
COMPND   4 SYNONYM: CARBOXYLESTERASE;
COMPND   5 EC: 3.1.1.1;
COMPND   6 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: SULFOLOBUS TOKODAII;
SOURCE   3 ORGANISM_TAXID: 111955;
SOURCE   4 STRAIN: 7;
SOURCE   5 GENE: ST0071;
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: BL21(DE3)CODONPLUS;
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PET28A+
KEYWDS    CARBOXYLESTERASE, THERMOPHILIC, DIMER, ARCHAEA, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    C.ANGKAWIDJAJA,S.KANAYA
REVDAT   1   08-JUN-11 3AIK    0
JRNL        AUTH   C.ANGKAWIDJAJA,Y.KOGA,K.TAKANO,S.KANAYA
JRNL        TITL   STRUCTURAL CHARACTERIZATION OF A HSL-LIKE CARBOXYLESTERASE
JRNL        TITL 2 FROM A THERMOACIDOPHILIC ARCHAEON SULFOLOBUS TOKODAII
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    1.95 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.5.0109
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD WITH PHASES
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.95
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 44.28
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.0
REMARK   3   NUMBER OF REFLECTIONS             : 113863
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.161
REMARK   3   R VALUE            (WORKING SET) : 0.159
REMARK   3   FREE R VALUE                     : 0.194
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000
REMARK   3   FREE R VALUE TEST SET COUNT      : 6045
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 1.95
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.00
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 8342
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 97.75
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2210
REMARK   3   BIN FREE R VALUE SET COUNT          : 433
REMARK   3   BIN FREE R VALUE                    : 0.2600
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 8948
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 105
REMARK   3   SOLVENT ATOMS            : 631
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 26.98
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : 0.12000
REMARK   3    B22 (A**2) : -0.12000
REMARK   3    B33 (A**2) : 0.13000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.19000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): NULL
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.113
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.073
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 2.565
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.967
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.952
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  9261 ; 0.011 ; 0.022
REMARK   3   BOND LENGTHS OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 12576 ; 1.122 ; 1.971
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  1128 ; 7.478 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   432 ;33.981 ;23.981
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  1480 ;17.574 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    48 ;17.005 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  1366 ; 0.101 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  7076 ; 0.017 ; 0.021
REMARK   3   GENERAL PLANES OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  5616 ; 1.696 ; 1.500
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  9056 ; 2.639 ; 2.000
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  3645 ; 4.398 ; 3.000
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  3520 ; 6.671 ; 4.500
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.40
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 3AIK COMPLIES WITH FORMAT V. 3.20, 01-DEC-08
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 01-JUN-10.
REMARK 100 THE RCSB ID CODE IS RCSB029296.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 20-OCT-09
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 8.5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SPRING-8
REMARK 200  BEAMLINE                       : BL44B2
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.0
REMARK 200  MONOCHROMATOR                  : DOUBLE-CRYSTAL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : MARMOSAIC 225 MM CCD
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 120550
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.950
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : -3.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.9
REMARK 200  DATA REDUNDANCY                : 6.100
REMARK 200  R MERGE                    (I) : 0.08500
REMARK 200  R SYM                      (I) : 0.06400
REMARK 200   FOR THE DATA SET  : 22.7000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.95
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.98
REMARK 200  COMPLETENESS FOR SHELL     (%) : 97.7
REMARK 200  DATA REDUNDANCY IN SHELL       : 5.90
REMARK 200  R MERGE FOR SHELL          (I) : 0.48900
REMARK 200  R SYM FOR SHELL            (I) : 0.42100
REMARK 200   FOR SHELL         : 3.100
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: MOLREP
REMARK 200 STARTING MODEL: 1JJI
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 58.17
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.94
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1M TRIS-HCL PH 8.5, 0.2M AMMONIUM
REMARK 280  PHOSPHATE MONOBASIC, 50% MPD, VAPOR DIFFUSION, SITTING DROP,
REMARK 280  TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       57.37600
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3, 4
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 3
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 1890 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 21600 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -16.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 4
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 1860 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 21760 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -15.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A   -19
REMARK 465     GLY A   -18
REMARK 465     SER A   -17
REMARK 465     SER A   -16
REMARK 465     HIS A   -15
REMARK 465     HIS A   -14
REMARK 465     HIS A   -13
REMARK 465     HIS A   -12
REMARK 465     HIS A   -11
REMARK 465     HIS A   -10
REMARK 465     SER A    -9
REMARK 465     SER A    -8
REMARK 465     GLY A    -7
REMARK 465     LEU A    -6
REMARK 465     VAL A    -5
REMARK 465     PRO A    -4
REMARK 465     ARG A    -3
REMARK 465     GLY A    -2
REMARK 465     SER A    -1
REMARK 465     HIS A     0
REMARK 465     MET A     1
REMARK 465     ILE A     2
REMARK 465     ASP A     3
REMARK 465     PRO A     4
REMARK 465     LYS A     5
REMARK 465     ILE A     6
REMARK 465     LYS A     7
REMARK 465     LYS A     8
REMARK 465     LEU A     9
REMARK 465     LEU A    10
REMARK 465     GLU A    11
REMARK 465     SER A    12
REMARK 465     THR A    13
REMARK 465     ILE A    14
REMARK 465     GLN A    15
REMARK 465     LEU A    16
REMARK 465     PRO A    17
REMARK 465     ILE A    18
REMARK 465     GLY A    19
REMARK 465     LYS A    20
REMARK 465     MET B   -19
REMARK 465     GLY B   -18
REMARK 465     SER B   -17
REMARK 465     SER B   -16
REMARK 465     HIS B   -15
REMARK 465     HIS B   -14
REMARK 465     HIS B   -13
REMARK 465     HIS B   -12
REMARK 465     HIS B   -11
REMARK 465     HIS B   -10
REMARK 465     SER B    -9
REMARK 465     SER B    -8
REMARK 465     GLY B    -7
REMARK 465     LEU B    -6
REMARK 465     VAL B    -5
REMARK 465     PRO B    -4
REMARK 465     ARG B    -3
REMARK 465     GLY B    -2
REMARK 465     SER B    -1
REMARK 465     HIS B     0
REMARK 465     MET B     1
REMARK 465     ILE B     2
REMARK 465     ASP B     3
REMARK 465     PRO B     4
REMARK 465     LYS B     5
REMARK 465     ILE B     6
REMARK 465     LYS B     7
REMARK 465     LYS B     8
REMARK 465     LEU B     9
REMARK 465     LEU B    10
REMARK 465     GLU B    11
REMARK 465     SER B    12
REMARK 465     THR B    13
REMARK 465     ILE B    14
REMARK 465     GLN B    15
REMARK 465     LEU B    16
REMARK 465     PRO B    17
REMARK 465     ILE B    18
REMARK 465     GLY B    19
REMARK 465     LYS B    20
REMARK 465     MET C   -19
REMARK 465     GLY C   -18
REMARK 465     SER C   -17
REMARK 465     SER C   -16
REMARK 465     HIS C   -15
REMARK 465     HIS C   -14
REMARK 465     HIS C   -13
REMARK 465     HIS C   -12
REMARK 465     HIS C   -11
REMARK 465     HIS C   -10
REMARK 465     SER C    -9
REMARK 465     SER C    -8
REMARK 465     GLY C    -7
REMARK 465     LEU C    -6
REMARK 465     VAL C    -5
REMARK 465     PRO C    -4
REMARK 465     ARG C    -3
REMARK 465     GLY C    -2
REMARK 465     SER C    -1
REMARK 465     HIS C     0
REMARK 465     MET C     1
REMARK 465     ILE C     2
REMARK 465     ASP C     3
REMARK 465     PRO C     4
REMARK 465     LYS C     5
REMARK 465     ILE C     6
REMARK 465     LYS C     7
REMARK 465     LYS C     8
REMARK 465     LEU C     9
REMARK 465     LEU C    10
REMARK 465     GLU C    11
REMARK 465     SER C    12
REMARK 465     THR C    13
REMARK 465     ILE C    14
REMARK 465     GLN C    15
REMARK 465     LEU C    16
REMARK 465     PRO C    17
REMARK 465     ILE C    18
REMARK 465     GLY C    19
REMARK 465     LYS C    20
REMARK 465     MET D   -19
REMARK 465     GLY D   -18
REMARK 465     SER D   -17
REMARK 465     SER D   -16
REMARK 465     HIS D   -15
REMARK 465     HIS D   -14
REMARK 465     HIS D   -13
REMARK 465     HIS D   -12
REMARK 465     HIS D   -11
REMARK 465     HIS D   -10
REMARK 465     SER D    -9
REMARK 465     SER D    -8
REMARK 465     GLY D    -7
REMARK 465     LEU D    -6
REMARK 465     VAL D    -5
REMARK 465     PRO D    -4
REMARK 465     ARG D    -3
REMARK 465     GLY D    -2
REMARK 465     SER D    -1
REMARK 465     HIS D     0
REMARK 465     MET D     1
REMARK 465     ILE D     2
REMARK 465     ASP D     3
REMARK 465     PRO D     4
REMARK 465     LYS D     5
REMARK 465     ILE D     6
REMARK 465     LYS D     7
REMARK 465     LYS D     8
REMARK 465     LEU D     9
REMARK 465     LEU D    10
REMARK 465     GLU D    11
REMARK 465     SER D    12
REMARK 465     THR D    13
REMARK 465     ILE D    14
REMARK 465     GLN D    15
REMARK 465     LEU D    16
REMARK 465     PRO D    17
REMARK 465     ILE D    18
REMARK 465     GLY D    19
REMARK 465     LYS D    20
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ASP A  85      174.85    175.11
REMARK 500    PHE A 117      140.38    -35.36
REMARK 500    PRO A 118       30.31    -92.23
REMARK 500    SER A 150     -121.93     58.50
REMARK 500    TYR A 177       61.93     31.30
REMARK 500    PHE A 197      -57.73     75.86
REMARK 500    HIS A 242       39.95    -95.51
REMARK 500    LYS B  44      138.73   -171.87
REMARK 500    ASP B  85     -179.68   -174.22
REMARK 500    SER B 150     -120.00     59.07
REMARK 500    TYR B 177       60.13     32.18
REMARK 500    PHE B 197      -60.00     76.63
REMARK 500    HIS B 242       55.53   -102.20
REMARK 500    VAL C  42     -167.69   -120.88
REMARK 500    LYS C  44      137.13   -170.65
REMARK 500    PHE C 117      137.64    -38.69
REMARK 500    SER C 150     -119.20     58.92
REMARK 500    TYR C 177       60.82     31.80
REMARK 500    PHE C 197      -61.09     74.06
REMARK 500    HIS C 242       44.79    -99.57
REMARK 500    ASP D  85     -177.45   -171.94
REMARK 500    PHE D 117      135.04    -36.18
REMARK 500    SER D 150     -121.35     64.56
REMARK 500    TYR D 177       59.75     34.33
REMARK 500    PHE D 197      -59.94     75.18
REMARK 500    HIS D 242       50.00   -103.98
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH A 597        DISTANCE =  5.77 ANGSTROMS
REMARK 525    HOH A 662        DISTANCE =  5.35 ANGSTROMS
REMARK 525    HOH B 534        DISTANCE =  5.04 ANGSTROMS
REMARK 525    HOH B 753        DISTANCE =  7.61 ANGSTROMS
REMARK 525    HOH B 754        DISTANCE =  5.92 ANGSTROMS
REMARK 525    HOH B 755        DISTANCE =  9.05 ANGSTROMS
REMARK 525    HOH B 756        DISTANCE =  9.52 ANGSTROMS
REMARK 525    HOH C 552        DISTANCE =  5.09 ANGSTROMS
REMARK 525    HOH C 602        DISTANCE =  6.34 ANGSTROMS
REMARK 525    HOH D 517        DISTANCE =  6.25 ANGSTROMS
REMARK 525    HOH D 545        DISTANCE =  5.89 ANGSTROMS
REMARK 525    HOH D 575        DISTANCE =  5.51 ANGSTROMS
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MPD A 304
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MRD A 305
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PO4 A 306
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PO4 A 307
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MPD B 304
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MPD B 305
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MPD B 306
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PO4 B 307
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MRD C 304
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MRD C 305
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MRD C 306
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PO4 C 307
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MRD D 304
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MRD D 305
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PO4 D 306
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 3AIL   RELATED DB: PDB
REMARK 900 RELATED ID: 3AIM   RELATED DB: PDB
REMARK 900 RELATED ID: 3AIN   RELATED DB: PDB
REMARK 900 RELATED ID: 3AIO   RELATED DB: PDB
DBREF  3AIK A    1   303  UNP    Q976W8   Q976W8_SULTO     1    303
DBREF  3AIK B    1   303  UNP    Q976W8   Q976W8_SULTO     1    303
DBREF  3AIK C    1   303  UNP    Q976W8   Q976W8_SULTO     1    303
DBREF  3AIK D    1   303  UNP    Q976W8   Q976W8_SULTO     1    303
SEQADV 3AIK MET A  -19  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK GLY A  -18  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK SER A  -17  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK SER A  -16  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS A  -15  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS A  -14  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS A  -13  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS A  -12  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS A  -11  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS A  -10  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK SER A   -9  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK SER A   -8  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK GLY A   -7  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK LEU A   -6  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK VAL A   -5  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK PRO A   -4  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK ARG A   -3  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK GLY A   -2  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK SER A   -1  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS A    0  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK MET B  -19  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK GLY B  -18  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK SER B  -17  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK SER B  -16  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS B  -15  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS B  -14  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS B  -13  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS B  -12  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS B  -11  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS B  -10  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK SER B   -9  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK SER B   -8  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK GLY B   -7  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK LEU B   -6  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK VAL B   -5  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK PRO B   -4  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK ARG B   -3  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK GLY B   -2  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK SER B   -1  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS B    0  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK MET C  -19  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK GLY C  -18  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK SER C  -17  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK SER C  -16  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS C  -15  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS C  -14  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS C  -13  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS C  -12  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS C  -11  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS C  -10  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK SER C   -9  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK SER C   -8  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK GLY C   -7  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK LEU C   -6  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK VAL C   -5  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK PRO C   -4  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK ARG C   -3  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK GLY C   -2  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK SER C   -1  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS C    0  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK MET D  -19  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK GLY D  -18  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK SER D  -17  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK SER D  -16  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS D  -15  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS D  -14  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS D  -13  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS D  -12  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS D  -11  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS D  -10  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK SER D   -9  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK SER D   -8  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK GLY D   -7  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK LEU D   -6  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK VAL D   -5  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK PRO D   -4  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK ARG D   -3  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK GLY D   -2  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK SER D   -1  UNP  Q976W8              EXPRESSION TAG
SEQADV 3AIK HIS D    0  UNP  Q976W8              EXPRESSION TAG
SEQRES   1 A  323  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 A  323  LEU VAL PRO ARG GLY SER HIS MET ILE ASP PRO LYS ILE
SEQRES   3 A  323  LYS LYS LEU LEU GLU SER THR ILE GLN LEU PRO ILE GLY
SEQRES   4 A  323  LYS ALA SER VAL GLU GLU ILE ARG SER LEU PHE LYS GLN
SEQRES   5 A  323  PHE SER SER LEU THR PRO ARG GLU GLU VAL GLY LYS ILE
SEQRES   6 A  323  GLU ASP ILE THR ILE PRO GLY SER GLU THR ASN ILE LYS
SEQRES   7 A  323  ALA ARG VAL TYR TYR PRO LYS THR GLN GLY PRO TYR GLY
SEQRES   8 A  323  VAL LEU VAL TYR TYR HIS GLY GLY GLY PHE VAL LEU GLY
SEQRES   9 A  323  ASP ILE GLU SER TYR ASP PRO LEU CYS ARG ALA ILE THR
SEQRES  10 A  323  ASN SER CYS GLN CYS VAL THR ILE SER VAL ASP TYR ARG
SEQRES  11 A  323  LEU ALA PRO GLU ASN LYS PHE PRO ALA ALA VAL VAL ASP
SEQRES  12 A  323  SER PHE ASP ALA LEU LYS TRP VAL TYR ASN ASN SER GLU
SEQRES  13 A  323  LYS PHE ASN GLY LYS TYR GLY ILE ALA VAL GLY GLY ASP
SEQRES  14 A  323  SER ALA GLY GLY ASN LEU ALA ALA VAL THR ALA ILE LEU
SEQRES  15 A  323  SER LYS LYS GLU ASN ILE LYS LEU LYS TYR GLN VAL LEU
SEQRES  16 A  323  ILE TYR PRO ALA VAL SER PHE ASP LEU ILE THR LYS SER
SEQRES  17 A  323  LEU TYR ASP ASN GLY GLU GLY PHE PHE LEU THR ARG GLU
SEQRES  18 A  323  HIS ILE ASP TRP PHE GLY GLN GLN TYR LEU ARG SER PHE
SEQRES  19 A  323  ALA ASP LEU LEU ASP PHE ARG PHE SER PRO ILE LEU ALA
SEQRES  20 A  323  ASP LEU ASN ASP LEU PRO PRO ALA LEU ILE ILE THR ALA
SEQRES  21 A  323  GLU HIS ASP PRO LEU ARG ASP GLN GLY GLU ALA TYR ALA
SEQRES  22 A  323  ASN LYS LEU LEU GLN SER GLY VAL GLN VAL THR SER VAL
SEQRES  23 A  323  ARG PHE ASN ASN VAL ILE HIS GLY PHE VAL SER PHE PHE
SEQRES  24 A  323  PRO PHE ILE GLU GLN GLY ARG ASP ALA ILE GLY LEU ILE
SEQRES  25 A  323  GLY TYR VAL LEU ARG LYS VAL PHE TYR GLY LYS
SEQRES   1 B  323  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 B  323  LEU VAL PRO ARG GLY SER HIS MET ILE ASP PRO LYS ILE
SEQRES   3 B  323  LYS LYS LEU LEU GLU SER THR ILE GLN LEU PRO ILE GLY
SEQRES   4 B  323  LYS ALA SER VAL GLU GLU ILE ARG SER LEU PHE LYS GLN
SEQRES   5 B  323  PHE SER SER LEU THR PRO ARG GLU GLU VAL GLY LYS ILE
SEQRES   6 B  323  GLU ASP ILE THR ILE PRO GLY SER GLU THR ASN ILE LYS
SEQRES   7 B  323  ALA ARG VAL TYR TYR PRO LYS THR GLN GLY PRO TYR GLY
SEQRES   8 B  323  VAL LEU VAL TYR TYR HIS GLY GLY GLY PHE VAL LEU GLY
SEQRES   9 B  323  ASP ILE GLU SER TYR ASP PRO LEU CYS ARG ALA ILE THR
SEQRES  10 B  323  ASN SER CYS GLN CYS VAL THR ILE SER VAL ASP TYR ARG
SEQRES  11 B  323  LEU ALA PRO GLU ASN LYS PHE PRO ALA ALA VAL VAL ASP
SEQRES  12 B  323  SER PHE ASP ALA LEU LYS TRP VAL TYR ASN ASN SER GLU
SEQRES  13 B  323  LYS PHE ASN GLY LYS TYR GLY ILE ALA VAL GLY GLY ASP
SEQRES  14 B  323  SER ALA GLY GLY ASN LEU ALA ALA VAL THR ALA ILE LEU
SEQRES  15 B  323  SER LYS LYS GLU ASN ILE LYS LEU LYS TYR GLN VAL LEU
SEQRES  16 B  323  ILE TYR PRO ALA VAL SER PHE ASP LEU ILE THR LYS SER
SEQRES  17 B  323  LEU TYR ASP ASN GLY GLU GLY PHE PHE LEU THR ARG GLU
SEQRES  18 B  323  HIS ILE ASP TRP PHE GLY GLN GLN TYR LEU ARG SER PHE
SEQRES  19 B  323  ALA ASP LEU LEU ASP PHE ARG PHE SER PRO ILE LEU ALA
SEQRES  20 B  323  ASP LEU ASN ASP LEU PRO PRO ALA LEU ILE ILE THR ALA
SEQRES  21 B  323  GLU HIS ASP PRO LEU ARG ASP GLN GLY GLU ALA TYR ALA
SEQRES  22 B  323  ASN LYS LEU LEU GLN SER GLY VAL GLN VAL THR SER VAL
SEQRES  23 B  323  ARG PHE ASN ASN VAL ILE HIS GLY PHE VAL SER PHE PHE
SEQRES  24 B  323  PRO PHE ILE GLU GLN GLY ARG ASP ALA ILE GLY LEU ILE
SEQRES  25 B  323  GLY TYR VAL LEU ARG LYS VAL PHE TYR GLY LYS
SEQRES   1 C  323  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 C  323  LEU VAL PRO ARG GLY SER HIS MET ILE ASP PRO LYS ILE
SEQRES   3 C  323  LYS LYS LEU LEU GLU SER THR ILE GLN LEU PRO ILE GLY
SEQRES   4 C  323  LYS ALA SER VAL GLU GLU ILE ARG SER LEU PHE LYS GLN
SEQRES   5 C  323  PHE SER SER LEU THR PRO ARG GLU GLU VAL GLY LYS ILE
SEQRES   6 C  323  GLU ASP ILE THR ILE PRO GLY SER GLU THR ASN ILE LYS
SEQRES   7 C  323  ALA ARG VAL TYR TYR PRO LYS THR GLN GLY PRO TYR GLY
SEQRES   8 C  323  VAL LEU VAL TYR TYR HIS GLY GLY GLY PHE VAL LEU GLY
SEQRES   9 C  323  ASP ILE GLU SER TYR ASP PRO LEU CYS ARG ALA ILE THR
SEQRES  10 C  323  ASN SER CYS GLN CYS VAL THR ILE SER VAL ASP TYR ARG
SEQRES  11 C  323  LEU ALA PRO GLU ASN LYS PHE PRO ALA ALA VAL VAL ASP
SEQRES  12 C  323  SER PHE ASP ALA LEU LYS TRP VAL TYR ASN ASN SER GLU
SEQRES  13 C  323  LYS PHE ASN GLY LYS TYR GLY ILE ALA VAL GLY GLY ASP
SEQRES  14 C  323  SER ALA GLY GLY ASN LEU ALA ALA VAL THR ALA ILE LEU
SEQRES  15 C  323  SER LYS LYS GLU ASN ILE LYS LEU LYS TYR GLN VAL LEU
SEQRES  16 C  323  ILE TYR PRO ALA VAL SER PHE ASP LEU ILE THR LYS SER
SEQRES  17 C  323  LEU TYR ASP ASN GLY GLU GLY PHE PHE LEU THR ARG GLU
SEQRES  18 C  323  HIS ILE ASP TRP PHE GLY GLN GLN TYR LEU ARG SER PHE
SEQRES  19 C  323  ALA ASP LEU LEU ASP PHE ARG PHE SER PRO ILE LEU ALA
SEQRES  20 C  323  ASP LEU ASN ASP LEU PRO PRO ALA LEU ILE ILE THR ALA
SEQRES  21 C  323  GLU HIS ASP PRO LEU ARG ASP GLN GLY GLU ALA TYR ALA
SEQRES  22 C  323  ASN LYS LEU LEU GLN SER GLY VAL GLN VAL THR SER VAL
SEQRES  23 C  323  ARG PHE ASN ASN VAL ILE HIS GLY PHE VAL SER PHE PHE
SEQRES  24 C  323  PRO PHE ILE GLU GLN GLY ARG ASP ALA ILE GLY LEU ILE
SEQRES  25 C  323  GLY TYR VAL LEU ARG LYS VAL PHE TYR GLY LYS
SEQRES   1 D  323  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 D  323  LEU VAL PRO ARG GLY SER HIS MET ILE ASP PRO LYS ILE
SEQRES   3 D  323  LYS LYS LEU LEU GLU SER THR ILE GLN LEU PRO ILE GLY
SEQRES   4 D  323  LYS ALA SER VAL GLU GLU ILE ARG SER LEU PHE LYS GLN
SEQRES   5 D  323  PHE SER SER LEU THR PRO ARG GLU GLU VAL GLY LYS ILE
SEQRES   6 D  323  GLU ASP ILE THR ILE PRO GLY SER GLU THR ASN ILE LYS
SEQRES   7 D  323  ALA ARG VAL TYR TYR PRO LYS THR GLN GLY PRO TYR GLY
SEQRES   8 D  323  VAL LEU VAL TYR TYR HIS GLY GLY GLY PHE VAL LEU GLY
SEQRES   9 D  323  ASP ILE GLU SER TYR ASP PRO LEU CYS ARG ALA ILE THR
SEQRES  10 D  323  ASN SER CYS GLN CYS VAL THR ILE SER VAL ASP TYR ARG
SEQRES  11 D  323  LEU ALA PRO GLU ASN LYS PHE PRO ALA ALA VAL VAL ASP
SEQRES  12 D  323  SER PHE ASP ALA LEU LYS TRP VAL TYR ASN ASN SER GLU
SEQRES  13 D  323  LYS PHE ASN GLY LYS TYR GLY ILE ALA VAL GLY GLY ASP
SEQRES  14 D  323  SER ALA GLY GLY ASN LEU ALA ALA VAL THR ALA ILE LEU
SEQRES  15 D  323  SER LYS LYS GLU ASN ILE LYS LEU LYS TYR GLN VAL LEU
SEQRES  16 D  323  ILE TYR PRO ALA VAL SER PHE ASP LEU ILE THR LYS SER
SEQRES  17 D  323  LEU TYR ASP ASN GLY GLU GLY PHE PHE LEU THR ARG GLU
SEQRES  18 D  323  HIS ILE ASP TRP PHE GLY GLN GLN TYR LEU ARG SER PHE
SEQRES  19 D  323  ALA ASP LEU LEU ASP PHE ARG PHE SER PRO ILE LEU ALA
SEQRES  20 D  323  ASP LEU ASN ASP LEU PRO PRO ALA LEU ILE ILE THR ALA
SEQRES  21 D  323  GLU HIS ASP PRO LEU ARG ASP GLN GLY GLU ALA TYR ALA
SEQRES  22 D  323  ASN LYS LEU LEU GLN SER GLY VAL GLN VAL THR SER VAL
SEQRES  23 D  323  ARG PHE ASN ASN VAL ILE HIS GLY PHE VAL SER PHE PHE
SEQRES  24 D  323  PRO PHE ILE GLU GLN GLY ARG ASP ALA ILE GLY LEU ILE
SEQRES  25 D  323  GLY TYR VAL LEU ARG LYS VAL PHE TYR GLY LYS
HET    MPD  A 304       8
HET    MRD  A 305       8
HET    PO4  A 306       5
HET    PO4  A 307       5
HET    MPD  B 304       8
HET    MPD  B 305       8
HET    MPD  B 306       8
HET    PO4  B 307       5
HET    MRD  C 304       8
HET    MRD  C 305       8
HET    MRD  C 306       8
HET    PO4  C 307       5
HET    MRD  D 304       8
HET    MRD  D 305       8
HET    PO4  D 306       5
HETNAM     MPD (4S)-2-METHYL-2,4-PENTANEDIOL
HETNAM     MRD (4R)-2-METHYLPENTANE-2,4-DIOL
HETNAM     PO4 PHOSPHATE ION
FORMUL   5  MPD    4(C6 H14 O2)
FORMUL   6  MRD    6(C6 H14 O2)
FORMUL   7  PO4    5(O4 P 3-)
FORMUL  20  HOH   *631(H2 O)
HELIX    1   1 SER A   22  SER A   35  1                                  14
HELIX    2   2 TYR A   89  GLN A  101  1                                  13
HELIX    3   3 PRO A  118  ASN A  134  1                                  17
HELIX    4   4 SER A  135  ASN A  139  5                                   5
HELIX    5   5 SER A  150  GLU A  166  1                                  17
HELIX    6   6 THR A  186  GLY A  193  1                                   8
HELIX    7   7 THR A  199  LEU A  211  1                                  13
HELIX    8   8 SER A  213  ASP A  219  5                                   7
HELIX    9   9 SER A  223  ALA A  227  5                                   5
HELIX   10  10 LEU A  245  SER A  259  1                                  15
HELIX   11  11 GLY A  274  PHE A  279  5                                   6
HELIX   12  12 ILE A  282  GLY A  302  1                                  21
HELIX   13  13 SER B   22  LEU B   36  1                                  15
HELIX   14  14 TYR B   89  GLN B  101  1                                  13
HELIX   15  15 PRO B  118  ASN B  134  1                                  17
HELIX   16  16 SER B  135  ASN B  139  5                                   5
HELIX   17  17 SER B  150  GLU B  166  1                                  17
HELIX   18  18 THR B  186  ASN B  192  1                                   7
HELIX   19  19 THR B  199  LEU B  211  1                                  13
HELIX   20  20 SER B  213  ASP B  219  5                                   7
HELIX   21  21 SER B  223  ALA B  227  5                                   5
HELIX   22  22 LEU B  245  SER B  259  1                                  15
HELIX   23  23 GLY B  274  PHE B  279  5                                   6
HELIX   24  24 ILE B  282  GLY B  302  1                                  21
HELIX   25  25 SER C   22  SER C   35  1                                  14
HELIX   26  26 TYR C   89  GLN C  101  1                                  13
HELIX   27  27 PRO C  118  ASN C  134  1                                  17
HELIX   28  28 SER C  135  ASN C  139  5                                   5
HELIX   29  29 SER C  150  GLU C  166  1                                  17
HELIX   30  30 THR C  186  ASN C  192  1                                   7
HELIX   31  31 THR C  199  LEU C  211  1                                  13
HELIX   32  32 SER C  213  ASP C  219  5                                   7
HELIX   33  33 SER C  223  ALA C  227  5                                   5
HELIX   34  34 LEU C  245  SER C  259  1                                  15
HELIX   35  35 GLY C  274  PHE C  279  5                                   6
HELIX   36  36 ILE C  282  GLY C  302  1                                  21
HELIX   37  37 SER D   22  SER D   35  1                                  14
HELIX   38  38 TYR D   89  GLN D  101  1                                  13
HELIX   39  39 PRO D  118  ASN D  134  1                                  17
HELIX   40  40 SER D  135  ASN D  139  5                                   5
HELIX   41  41 SER D  150  GLU D  166  1                                  17
HELIX   42  42 THR D  186  ASN D  192  1                                   7
HELIX   43  43 THR D  199  LEU D  211  1                                  13
HELIX   44  44 SER D  213  ASP D  219  5                                   7
HELIX   45  45 SER D  223  ALA D  227  5                                   5
HELIX   46  46 LEU D  245  SER D  259  1                                  15
HELIX   47  47 GLY D  274  PHE D  279  5                                   6
HELIX   48  48 ILE D  282  GLY D  302  1                                  21
SHEET    1   A16 LYS A  44  PRO A  51  0
SHEET    2   A16 ASN A  56  TYR A  63 -1  O  TYR A  63   N  LYS A  44
SHEET    3   A16 VAL A 103  VAL A 107 -1  O  THR A 104   N  TYR A  62
SHEET    4   A16 VAL A  72  TYR A  76  1  N  LEU A  73   O  VAL A 103
SHEET    5   A16 ILE A 144  ASP A 149  1  O  ALA A 145   N  VAL A  74
SHEET    6   A16 TYR A 172  ILE A 176  1  O  ILE A 176   N  GLY A 148
SHEET    7   A16 ALA A 235  ALA A 240  1  O  LEU A 236   N  LEU A 175
SHEET    8   A16 VAL A 263  PHE A 268  1  O  PHE A 268   N  THR A 239
SHEET    9   A16 VAL D 263  ILE D 272 -1  O  ARG D 267   N  ARG A 267
SHEET   10   A16 ALA D 235  HIS D 242  1  N  THR D 239   O  PHE D 268
SHEET   11   A16 TYR D 172  ILE D 176  1  N  LEU D 175   O  LEU D 236
SHEET   12   A16 ILE D 144  ASP D 149  1  N  GLY D 148   O  ILE D 176
SHEET   13   A16 VAL D  72  TYR D  76  1  N  VAL D  74   O  ALA D 145
SHEET   14   A16 VAL D 103  VAL D 107  1  O  VAL D 103   N  LEU D  73
SHEET   15   A16 ASN D  56  TYR D  63 -1  N  TYR D  62   O  THR D 104
SHEET   16   A16 LYS D  44  PRO D  51 -1  N  GLU D  46   O  VAL D  61
SHEET    1   B16 LYS B  44  PRO B  51  0
SHEET    2   B16 ASN B  56  TYR B  63 -1  O  ILE B  57   N  ILE B  50
SHEET    3   B16 VAL B 103  VAL B 107 -1  O  THR B 104   N  TYR B  62
SHEET    4   B16 GLY B  71  TYR B  76  1  N  LEU B  73   O  VAL B 103
SHEET    5   B16 GLY B 143  ASP B 149  1  O  ALA B 145   N  VAL B  72
SHEET    6   B16 TYR B 172  ILE B 176  1  O  ILE B 176   N  GLY B 148
SHEET    7   B16 ALA B 235  HIS B 242  1  O  LEU B 236   N  LEU B 175
SHEET    8   B16 VAL B 263  ILE B 272  1  O  PHE B 268   N  THR B 239
SHEET    9   B16 VAL C 263  ILE C 272 -1  O  SER C 265   N  ASN B 269
SHEET   10   B16 ALA C 235  HIS C 242  1  N  ILE C 237   O  VAL C 266
SHEET   11   B16 TYR C 172  ILE C 176  1  N  LEU C 175   O  LEU C 236
SHEET   12   B16 ILE C 144  ASP C 149  1  N  VAL C 146   O  VAL C 174
SHEET   13   B16 VAL C  72  TYR C  76  1  N  VAL C  74   O  ALA C 145
SHEET   14   B16 VAL C 103  VAL C 107  1  O  VAL C 103   N  LEU C  73
SHEET   15   B16 ASN C  56  TYR C  63 -1  N  TYR C  62   O  THR C 104
SHEET   16   B16 LYS C  44  PRO C  51 -1  N  GLU C  46   O  VAL C  61
SSBOND   1 CYS A  100    CYS A  102                          1555   1555  2.12
SSBOND   2 CYS B  100    CYS B  102                          1555   1555  2.12
SSBOND   3 CYS D  100    CYS D  102                          1555   1555  2.11
CISPEP   1 GLY A   68    PRO A   69          0        -0.62
CISPEP   2 ALA A  112    PRO A  113          0        -2.29
CISPEP   3 PHE A  117    PRO A  118          0        -2.55
CISPEP   4 GLY B   68    PRO B   69          0         3.77
CISPEP   5 ALA B  112    PRO B  113          0         5.23
CISPEP   6 PHE B  117    PRO B  118          0         4.94
CISPEP   7 GLY C   68    PRO C   69          0        -0.21
CISPEP   8 ALA C  112    PRO C  113          0         2.74
CISPEP   9 PHE C  117    PRO C  118          0         3.72
CISPEP  10 GLY D   68    PRO D   69          0        -3.76
CISPEP  11 ALA D  112    PRO D  113          0         4.06
CISPEP  12 PHE D  117    PRO D  118          0         4.96
SITE     1 AC1  6 PHE A  81  ALA A 151  ALA A 179  PHE A 206
SITE     2 AC1  6 LEU A 245  HOH A 347
SITE     1 AC2  7 PHE A 182  LEU A 217  LEU A 218  HOH A 336
SITE     2 AC2  7 SER B 181  PHE B 182  SER B 223
SITE     1 AC3  4 GLY A  79  TYR A  89  PHE A 197  HOH A 395
SITE     1 AC4  3 PRO A 118  ARG A 212  ARG A 221
SITE     1 AC5  7 PHE B  81  ALA B 151  ALA B 179  PHE B 206
SITE     2 AC5  7 GLY B 207  LEU B 245  HOH B 526
SITE     1 AC6  6 SER B  34  THR B  37  SER B  88  PRO B  91
SITE     2 AC6  6 LEU B  92  SER B 277
SITE     1 AC7  6 PHE B  30  GLY B  79  TYR B  89  HIS B 273
SITE     2 AC7  6 SER B 277  HOH B 345
SITE     1 AC8  3 ARG B 212  ARG B 221  HOH B 490
SITE     1 AC9  5 PHE C  81  ALA C 179  PHE C 206  LEU C 245
SITE     2 AC9  5 HOH C 578
SITE     1 BC1  5 GLY C 207  GLN C 208  SER C 213  HOH C 509
SITE     2 BC1  5 HOH C 631
SITE     1 BC2  2 SER C 181  HOH C 410
SITE     1 BC3  3 ARG C 212  ARG C 221  HOH C 493
SITE     1 BC4  6 PHE D  81  ALA D 151  ALA D 179  GLY D 207
SITE     2 BC4  6 LEU D 245  HOH D 528
SITE     1 BC5  2 GLY D 207  SER D 213
SITE     1 BC6  2 ARG D 212  ARG D 221
CRYST1   76.327  114.752  102.206  90.00 108.84  90.00 P 1 21 1      8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.013102  0.000000  0.004471        0.00000
SCALE2      0.000000  0.008714  0.000000        0.00000
SCALE3      0.000000  0.000000  0.010338        0.00000
TER    2238      LYS A 303
TER    4476      LYS B 303
TER    6714      LYS C 303
TER    8952      LYS D 303
MASTER      550    0   15   48   32    0   23    6 9684    4  111  100
END