longtext: 3BL8-pdb

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HEADER    CELL ADHESION                           10-DEC-07   3BL8
TITLE     CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF NEUROLIGIN-
TITLE    2 2A FROM MOUSE
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: NEUROLIGIN-2;
COMPND   3 CHAIN: A, B, C, D;
COMPND   4 FRAGMENT: ESTERASE-LIKE DOMAIN;
COMPND   5 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: MUS MUSCULUS;
SOURCE   3 ORGANISM_COMMON: MOUSE;
SOURCE   4 GENE: NLGN2, KIAA1366;
SOURCE   5 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE   6 EXPRESSION_SYSTEM_COMMON: HUMAN;
SOURCE   7 EXPRESSION_SYSTEM_STRAIN: GNTI;
SOURCE   8 EXPRESSION_SYSTEM_CELL_LINE: HEK293;
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PCEP4-NL2A
KEYWDS    NEUROLIGIN-2A, CELL ADHESION, GLYCOPROTEIN, MEMBRANE,
KEYWDS   2 PHOSPHOPROTEIN, TRANSMEMBRANE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    X.JIN,J.KOEHNKE,L.SHAPIRO
REVDAT   1   19-FEB-08 3BL8    0
JRNL        AUTH   J.KOEHNKE,X.JIN,E.C.BUDRECK,S.POSY,P.SCHEIFFELE,
JRNL        AUTH 2 B.HONIG,L.SHAPIRO
JRNL        TITL   CRYSTAL STRUCTURE OF THE EXTRACELLULAR
JRNL        TITL 2 CHOLINESTERASE-LIKE DOMAIN FROM NEUROLIGIN-2.
JRNL        REF    PROC.NATL.ACAD.SCI.USA                     2008
JRNL        REFN   ASTM PNASA6  US ESSN 1091-6490
REMARK   1
REMARK   2
REMARK   2 RESOLUTION. 3.30 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.2.0019
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 3.30
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 20.00
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.5
REMARK   3   NUMBER OF REFLECTIONS             : 54190
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.221
REMARK   3   R VALUE            (WORKING SET) : 0.219
REMARK   3   FREE R VALUE                     : 0.262
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000
REMARK   3   FREE R VALUE TEST SET COUNT      : 2714
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH           : 3.30
REMARK   3   BIN RESOLUTION RANGE LOW            : 3.38
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 3578
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 96.69
REMARK   3   BIN R VALUE           (WORKING SET) : 0.3320
REMARK   3   BIN FREE R VALUE SET COUNT          : 190
REMARK   3   BIN FREE R VALUE                    : 0.3250
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   ALL ATOMS                : 17374
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 126.20
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : 1.45000
REMARK   3    B22 (A**2) : -2.62000
REMARK   3    B33 (A**2) : -1.52000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : -9.25000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): NULL
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.513
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.467
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 61.915
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.944
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.918
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A): 17826 ; 0.008 ; 0.022
REMARK   3   BOND LENGTHS OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 24315 ; 1.213 ; 1.957
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  2179 ; 6.050 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   851 ;36.639 ;24.101
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  2691 ;19.917 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):   100 ;16.001 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  2632 ; 0.086 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A): 13892 ; 0.003 ; 0.020
REMARK   3   GENERAL PLANES OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  8863 ; 0.209 ; 0.200
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A): 12039 ; 0.309 ; 0.200
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):   522 ; 0.137 ; 0.200
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):    44 ; 0.213 ; 0.200
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):     5 ; 0.106 ; 0.200
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2): 11096 ; 0.278 ; 1.500
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2): 17560 ; 0.510 ; 2.000
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  7612 ; 0.528 ; 3.000
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  6754 ; 0.937 ; 4.500
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : 0
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 4
REMARK   3
REMARK   3   TLS GROUP : 1
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A    42        A   605
REMARK   3    ORIGIN FOR THE GROUP (A):  48.4989  46.6581  10.9178
REMARK   3    T TENSOR
REMARK   3      T11:  -0.6722 T22:  -0.8698
REMARK   3      T33:  -0.6265 T12:  -0.0323
REMARK   3      T13:   0.0460 T23:  -0.0829
REMARK   3    L TENSOR
REMARK   3      L11:   3.2225 L22:   3.7692
REMARK   3      L33:   2.1452 L12:   0.0194
REMARK   3      L13:  -0.5863 L23:  -0.7020
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0827 S12:  -0.4679 S13:   0.0174
REMARK   3      S21:   0.4323 S22:   0.1417 S23:  -0.2159
REMARK   3      S31:   0.0163 S32:   0.0725 S33:  -0.0590
REMARK   3
REMARK   3   TLS GROUP : 2
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   B    42        B   605
REMARK   3    ORIGIN FOR THE GROUP (A): -16.8399  51.0350  40.7273
REMARK   3    T TENSOR
REMARK   3      T11:  -0.2211 T22:  -0.0598
REMARK   3      T33:  -0.3587 T12:   0.0820
REMARK   3      T13:  -0.0656 T23:  -0.1192
REMARK   3    L TENSOR
REMARK   3      L11:   3.1231 L22:   2.2111
REMARK   3      L33:   7.2258 L12:  -0.1973
REMARK   3      L13:   2.9054 L23:  -0.4658
REMARK   3    S TENSOR
REMARK   3      S11:  -0.3199 S12:  -0.7861 S13:   0.3309
REMARK   3      S21:   0.4620 S22:   0.0780 S23:  -0.3425
REMARK   3      S31:  -0.9331 S32:   0.3689 S33:   0.2419
REMARK   3
REMARK   3   TLS GROUP : 3
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   C    42        C   605
REMARK   3    ORIGIN FOR THE GROUP (A):  19.3197  11.5225  52.7535
REMARK   3    T TENSOR
REMARK   3      T11:  -0.1688 T22:  -0.1707
REMARK   3      T33:  -0.1770 T12:  -0.0989
REMARK   3      T13:   0.0131 T23:   0.1926
REMARK   3    L TENSOR
REMARK   3      L11:   2.8765 L22:   2.4094
REMARK   3      L33:   3.8842 L12:   0.7513
REMARK   3      L13:   0.0117 L23:  -1.2379
REMARK   3    S TENSOR
REMARK   3      S11:   0.2119 S12:  -0.4134 S13:  -0.4720
REMARK   3      S21:   0.3166 S22:  -0.0303 S23:  -0.0864
REMARK   3      S31:   0.2677 S32:  -0.2045 S33:  -0.1816
REMARK   3
REMARK   3   TLS GROUP : 4
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   D    42        D   605
REMARK   3    ORIGIN FOR THE GROUP (A):  16.4060  47.4783  92.7006
REMARK   3    T TENSOR
REMARK   3      T11:   0.2362 T22:   0.7312
REMARK   3      T33:  -0.2204 T12:  -0.0784
REMARK   3      T13:  -0.2434 T23:  -0.5033
REMARK   3    L TENSOR
REMARK   3      L11:   5.1357 L22:   1.6449
REMARK   3      L33:   4.7656 L12:   0.1773
REMARK   3      L13:   3.2354 L23:   0.1363
REMARK   3    S TENSOR
REMARK   3      S11:   0.2706 S12:   0.0768 S13:  -0.4014
REMARK   3      S21:   0.0210 S22:   0.2845 S23:  -0.0706
REMARK   3      S31:   0.3305 S32:  -0.5432 S33:  -0.5551
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE
REMARK   3  RIDING POSITIONS
REMARK   4
REMARK   4 3BL8 COMPLIES WITH FORMAT V. 3.1, 01-AUG-2007
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB.
REMARK 100 THE RCSB ID CODE IS RCSB045658.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 07-JUN-2007
REMARK 200  TEMPERATURE           (KELVIN) : 100.0
REMARK 200  PH                             : 8.80
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : NSLS
REMARK 200  BEAMLINE                       : X4C
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9793
REMARK 200  MONOCHROMATOR                  : SI 111
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : MAR CCD 165 MM
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL
REMARK 200  DATA SCALING SOFTWARE          : HKL
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 54385
REMARK 200  RESOLUTION RANGE HIGH      (A) : 3.300
REMARK 200  RESOLUTION RANGE LOW       (A) : 30.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 0.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.6
REMARK 200  DATA REDUNDANCY                : 3.100
REMARK 200  R MERGE                    (I) : 0.10100
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 7.9000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.30
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 3.42
REMARK 200  COMPLETENESS FOR SHELL     (%) : 96.9
REMARK 200  DATA REDUNDANCY IN SHELL       : 2.80
REMARK 200  R MERGE FOR SHELL          (I) : 0.50300
REMARK 200  R SYM FOR SHELL            (I) : 0.50300
REMARK 200   FOR SHELL         : 1.400
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 65.55
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.57
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 3.5% PEG 6000, 0.1M BICINE, PH 8.8,
REMARK 280  VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 1 2 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y,-Z
REMARK 290       3555   1/2+X,1/2+Y,Z
REMARK 290       4555   1/2-X,1/2+Y,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   3  1.000000  0.000000  0.000000      107.36150
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       46.28350
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000      107.36150
REMARK 290   SMTRY2   4  0.000000  1.000000  0.000000       46.28350
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMER
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMER
REMARK 350 SOFTWARE USED: PISA
REMARK 350 AVERAGE BURIED SURFACE AREA: 2560 ANGSTROM**2
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMER
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMER
REMARK 350 SOFTWARE USED: PISA
REMARK 350 AVERAGE BURIED SURFACE AREA: 2980 ANGSTROM**2
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C  SSEQI
REMARK 465     ARG A   159
REMARK 465     ASP A   160
REMARK 465     GLU A   161
REMARK 465     ALA A   162
REMARK 465     THR A   163
REMARK 465     LEU A   164
REMARK 465     ASN A   165
REMARK 465     PRO A   166
REMARK 465     PRO A   167
REMARK 465     ASP A   168
REMARK 465     THR A   169
REMARK 465     ASP A   170
REMARK 465     ILE A   171
REMARK 465     ARG A   172
REMARK 465     ASN A   610
REMARK 465     LEU A   611
REMARK 465     HIS A   612
REMARK 465     HIS A   613
REMARK 465     HIS A   614
REMARK 465     HIS A   615
REMARK 465     HIS A   616
REMARK 465     HIS A   617
REMARK 465     HIS A   618
REMARK 465     HIS A   619
REMARK 465     GLU B   151
REMARK 465     ASP B   152
REMARK 465     GLY B   153
REMARK 465     PRO B   154
REMARK 465     LEU B   155
REMARK 465     THR B   156
REMARK 465     LYS B   157
REMARK 465     LYS B   158
REMARK 465     ARG B   159
REMARK 465     ASP B   160
REMARK 465     GLU B   161
REMARK 465     ALA B   162
REMARK 465     THR B   163
REMARK 465     LEU B   164
REMARK 465     ASN B   165
REMARK 465     PRO B   166
REMARK 465     PRO B   167
REMARK 465     ASP B   168
REMARK 465     THR B   169
REMARK 465     ASP B   170
REMARK 465     ILE B   171
REMARK 465     ARG B   172
REMARK 465     ASP B   173
REMARK 465     HIS B   609
REMARK 465     ASN B   610
REMARK 465     LEU B   611
REMARK 465     HIS B   612
REMARK 465     HIS B   613
REMARK 465     HIS B   614
REMARK 465     HIS B   615
REMARK 465     HIS B   616
REMARK 465     HIS B   617
REMARK 465     HIS B   618
REMARK 465     HIS B   619
REMARK 465     GLN C    40
REMARK 465     GLU C   151
REMARK 465     ASP C   152
REMARK 465     GLY C   153
REMARK 465     PRO C   154
REMARK 465     LEU C   155
REMARK 465     THR C   156
REMARK 465     LYS C   157
REMARK 465     LYS C   158
REMARK 465     ARG C   159
REMARK 465     ASP C   160
REMARK 465     GLU C   161
REMARK 465     ALA C   162
REMARK 465     THR C   163
REMARK 465     LEU C   164
REMARK 465     ASN C   165
REMARK 465     PRO C   166
REMARK 465     PRO C   167
REMARK 465     ASP C   168
REMARK 465     THR C   169
REMARK 465     ASP C   170
REMARK 465     ILE C   171
REMARK 465     ARG C   172
REMARK 465     ASP C   173
REMARK 465     SER C   174
REMARK 465     GLY C   175
REMARK 465     LEU C   611
REMARK 465     HIS C   612
REMARK 465     HIS C   613
REMARK 465     HIS C   614
REMARK 465     HIS C   615
REMARK 465     HIS C   616
REMARK 465     HIS C   617
REMARK 465     HIS C   618
REMARK 465     HIS C   619
REMARK 465     GLN D    40
REMARK 465     GLU D   151
REMARK 465     ASP D   152
REMARK 465     GLY D   153
REMARK 465     PRO D   154
REMARK 465     LEU D   155
REMARK 465     THR D   156
REMARK 465     LYS D   157
REMARK 465     LYS D   158
REMARK 465     ARG D   159
REMARK 465     ASP D   160
REMARK 465     GLU D   161
REMARK 465     ALA D   162
REMARK 465     THR D   163
REMARK 465     LEU D   164
REMARK 465     ASN D   165
REMARK 465     PRO D   166
REMARK 465     PRO D   167
REMARK 465     ASP D   168
REMARK 465     THR D   169
REMARK 465     ASP D   170
REMARK 465     ILE D   171
REMARK 465     ARG D   172
REMARK 465     ASP D   173
REMARK 465     SER D   174
REMARK 465     ILE D   558
REMARK 465     HIS D   559
REMARK 465     THR D   560
REMARK 465     LYS D   561
REMARK 465     PRO D   562
REMARK 465     LEU D   611
REMARK 465     HIS D   612
REMARK 465     HIS D   613
REMARK 465     HIS D   614
REMARK 465     HIS D   615
REMARK 465     HIS D   616
REMARK 465     HIS D   617
REMARK 465     HIS D   618
REMARK 465     HIS D   619
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS(M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     GLN A  40    CG    CD    OE1   NE2
REMARK 470     LYS A 158    CG    CD    CE    NZ
REMARK 470     VAL A 210    CG1   CG2
REMARK 470     GLN B  40    CG    CD    OE1   NE2
REMARK 470     VAL B 210    CG1   CG2
REMARK 470     LYS C  41    CG    CD    CE    NZ
REMARK 470     VAL C 210    CG1   CG2
REMARK 470     VAL D 210    CG1   CG2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI
REMARK 500   ND2  ASN B    98     O5   NAG B   801              1.61
REMARK 500   O    ARG A   335     OD2  ASP A   339              1.91
REMARK 500   O    PRO A   421     N    LYS A   424              1.97
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCELIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    ALA A 395   CB  -  CA  -  C   ANGL. DEV. = -13.5 DEGREES
REMARK 500    ALA A 496   N   -  CA  -  C   ANGL. DEV. = -17.0 DEGREES
REMARK 500    ALA B 345   CB  -  CA  -  C   ANGL. DEV. =  11.1 DEGREES
REMARK 500    GLU B 396   CB  -  CA  -  C   ANGL. DEV. = -19.0 DEGREES
REMARK 500    GLY D 112   N   -  CA  -  C   ANGL. DEV. =  20.2 DEGREES
REMARK 500    ALA D 113   N   -  CA  -  CB  ANGL. DEV. =  11.5 DEGREES
REMARK 500    HIS D 279   CB  -  CA  -  C   ANGL. DEV. = -16.7 DEGREES
REMARK 500    HIS D 279   N   -  CA  -  C   ANGL. DEV. =  24.3 DEGREES
REMARK 500    SER D 280   N   -  CA  -  C   ANGL. DEV. = -16.5 DEGREES
REMARK 500    SER D 291   N   -  CA  -  C   ANGL. DEV. =  18.9 DEGREES
REMARK 500    CYS D 521   CB  -  CA  -  C   ANGL. DEV. =  11.3 DEGREES
REMARK 500    ARG D 564   CB  -  CA  -  C   ANGL. DEV. = -14.6 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ALA A  81       26.43    -71.80
REMARK 500    PRO A 115       43.47    -73.21
REMARK 500    CYS A 141       -3.18   -149.50
REMARK 500    GLU A 151     -166.45   -120.23
REMARK 500    ALA A 229       90.44   -170.02
REMARK 500    GLU A 281      -79.68   -135.05
REMARK 500    GLN A 285       11.94   -150.79
REMARK 500    THR A 293      149.57   -172.27
REMARK 500    SER A 297       -8.56    -57.51
REMARK 500    ASP A 341       80.77     59.61
REMARK 500    ASP A 358      -83.87   -108.07
REMARK 500    PRO A 364      -36.23    -38.99
REMARK 500    GLU A 372       55.60   -102.58
REMARK 500    GLU A 386      -74.35    -51.57
REMARK 500    GLU A 398       33.04     70.16
REMARK 500    ASP A 399       17.39   -152.79
REMARK 500    TYR A 418      -50.65   -137.58
REMARK 500    TYR A 420       16.00   -151.68
REMARK 500    GLN A 475       22.26     86.10
REMARK 500    HIS A 485      125.70   -176.57
REMARK 500    GLU A 494       42.99    -87.03
REMARK 500    THR A 516     -169.30   -112.28
REMARK 500    PHE A 519       72.52   -119.23
REMARK 500    PRO A 520       45.27   -103.94
REMARK 500    ASN A 540       -9.49    -58.99
REMARK 500    PRO A 550      -94.56      7.84
REMARK 500    HIS A 559      158.13    -46.80
REMARK 500    ASN A 592       70.81     61.45
REMARK 500    ASN A 596      -71.77    -48.25
REMARK 500    GLU A 603      -64.90    -91.74
REMARK 500    ALA B  89      151.95    -48.52
REMARK 500    HIS B 111       54.93   -107.34
REMARK 500    SER B 138      132.85   -175.18
REMARK 500    HIS B 184     -161.43    -77.51
REMARK 500    SER B 187     -166.99   -100.22
REMARK 500    THR B 192      143.65   -175.67
REMARK 500    ASN B 206       68.40     61.49
REMARK 500    PHE B 221       -6.21   -141.07
REMARK 500    ASN B 232       10.54     58.37
REMARK 500    HIS B 279      -40.53    -27.35
REMARK 500    CYS B 317       32.63   -147.44
REMARK 500    SER B 322      -73.39    -58.15
REMARK 500    ASP B 358      -66.34   -146.77
REMARK 500    GLN B 370       22.05    -78.98
REMARK 500    ASN B 375       91.59    -62.02
REMARK 500    GLU B 398     -129.23     52.02
REMARK 500    ASP B 399     -120.14    -76.81
REMARK 500    SER B 402      105.47    -47.86
REMARK 500    ALA B 403      -57.34     70.90
REMARK 500    TYR B 418      -82.91   -109.85
REMARK 500    LYS B 424      -74.26    -91.38
REMARK 500    TYR B 435       49.56   -102.37
REMARK 500    TRP B 460      -54.23   -126.60
REMARK 500    GLN B 475       -5.98     74.05
REMARK 500    TYR B 484       65.87   -107.09
REMARK 500    HIS B 485      140.81   -175.24
REMARK 500    GLN B 488       88.91    -64.86
REMARK 500    ASP B 497     -169.81   -101.88
REMARK 500    ALA B 498      104.74    -54.47
REMARK 500    ASP B 502       -1.95    -58.80
REMARK 500    ASN B 522       94.28    -69.41
REMARK 500    GLN B 549      114.13   -163.13
REMARK 500    GLN B 553       48.16    -74.39
REMARK 500    THR B 555       71.54    -64.22
REMARK 500    PRO B 562       96.57    -19.64
REMARK 500    ASN B 563       93.26    -64.27
REMARK 500    LYS B 586       76.40   -118.66
REMARK 500    ASN B 592      105.41   -160.18
REMARK 500    ARG B 594       29.12     49.47
REMARK 500    ALA C  47        1.97    -68.19
REMARK 500    PHE C  69       67.10   -107.48
REMARK 500    PRO C  77      118.50    -33.79
REMARK 500    GLU C  88     -162.48   -129.96
REMARK 500    ASN C  98       58.75    -95.43
REMARK 500    ALA C  99       49.79    -79.78
REMARK 500    LEU C 142       84.14    -68.85
REMARK 500    HIS C 184     -167.93    -75.56
REMARK 500    TYR C 188      -10.07     74.94
REMARK 500    ASP C 226      -69.96   -146.55
REMARK 500    GLN C 227      -54.74   -125.21
REMARK 500    ARG C 258       38.74   -146.27
REMARK 500    GLU C 281      -74.21   -121.22
REMARK 500    TRP C 298       38.04    -98.63
REMARK 500    ASP C 341       45.12     78.75
REMARK 500    TYR C 347        5.70     81.74
REMARK 500    ASP C 358      -79.46   -127.58
REMARK 500    VAL C 391       52.30   -111.22
REMARK 500    ASP C 393       -8.99    -54.45
REMARK 500    SER C 394       55.95   -108.82
REMARK 500    SER C 397      -52.09   -121.89
REMARK 500    GLU C 398      -65.52     69.38
REMARK 500    ASP C 399        7.71    -66.65
REMARK 500    GLU C 422      -50.78     78.42
REMARK 500    TRP C 438      -46.82     70.35
REMARK 500    ALA C 489       75.30     52.41
REMARK 500    GLU C 490      153.98    -46.22
REMARK 500    ASP C 497       72.27     46.78
REMARK 500    ALA C 498       61.14     66.98
REMARK 500    PRO C 511       -9.04    -56.77
REMARK 500    ASN C 522       97.06    -67.16
REMARK 500    THR C 560       22.65    -72.35
REMARK 500    PRO C 562       98.40    -31.52
REMARK 500    ASN C 563       93.83    -66.11
REMARK 500    ASN C 574     -166.63   -100.65
REMARK 500    LYS C 576      -71.92    -59.13
REMARK 500    GLU C 603      -62.44    -93.02
REMARK 500    LEU C 608       39.31    -88.93
REMARK 500    PRO D  42      120.60    -15.67
REMARK 500    PRO D  94      -99.81    -58.61
REMARK 500    ALA D  99       47.00   -105.38
REMARK 500    ASN D 126       40.60    -89.52
REMARK 500    HIS D 184       53.80   -102.19
REMARK 500    TYR D 188       -7.69    -58.11
REMARK 500    PRO D 256       26.08    -66.67
REMARK 500    TRP D 298       32.44    -91.94
REMARK 500    GLN D 303       77.88   -117.17
REMARK 500    GLN D 340      -36.10   -139.23
REMARK 500    PRO D 344     -164.57    -70.36
REMARK 500    ASP D 358      -72.66   -122.54
REMARK 500    PRO D 361      -74.36    -59.29
REMARK 500    ASP D 362     -155.58   -102.30
REMARK 500    PHE D 373       44.38    -77.95
REMARK 500    ALA D 395      -47.53   -133.62
REMARK 500    ASP D 415       10.96    -68.06
REMARK 500    TYR D 418      -90.85   -123.63
REMARK 500    TYR D 435       66.42   -116.85
REMARK 500    TRP D 460      -59.19   -130.81
REMARK 500    GLN D 475       95.14    -60.12
REMARK 500    ALA D 498       72.07     49.60
REMARK 500    ALA D 515      125.01     99.43
REMARK 500    SER D 524     -169.73   -116.54
REMARK 500    THR D 544      -31.59   -135.79
REMARK 500    ARG D 564       18.45     51.55
REMARK 500    PHE D 565       -8.41   -141.52
REMARK 500    LYS D 578       58.22     31.12
REMARK 500    ARG D 594       36.14     37.74
REMARK 500    GLU D 603      -73.11    -95.92
REMARK 500    HIS D 607       21.56    -73.89
REMARK 500    HIS D 609      -78.34   -139.41
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500                                 MODEL     OMEGA
REMARK 500 TYR A  418    GLY A  419                 -147.54
REMARK 500 GLY A  419    TYR A  420                 -149.43
REMARK 500 TYR A  420    PRO A  421                  -51.12
REMARK 500 GLU A  494    TRP A  495                  135.40
REMARK 500 GLN A  549    PRO A  550                 -124.45
REMARK 500 PRO B   78    LEU B   79                 -149.99
REMARK 500 SER B  402    ALA B  403                  140.79
REMARK 500 ASP B  517    LEU B  518                 -146.50
REMARK 500 LEU B  518    PHE B  519                  139.89
REMARK 500 GLN C  549    PRO C  550                   48.97
REMARK 500 GLY D  371    GLU D  372                  137.61
REMARK 500 GLU D  396    SER D  397                  148.72
REMARK 500 GLN D  549    PRO D  550                   33.73
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M=MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH C 621        DISTANCE =  5.87 ANGSTROMS
REMARK 525    HOH D 621        DISTANCE =  8.55 ANGSTROMS
REMARK 525    HOH D 622        DISTANCE = 12.24 ANGSTROMS
REMARK 525    HOH D 623        DISTANCE = 15.59 ANGSTROMS
REMARK 525    HOH B 816        DISTANCE =  7.25 ANGSTROMS
REMARK 525    HOH B 821        DISTANCE =  5.75 ANGSTROMS
REMARK 610
REMARK 610 MISSING HETEROATOM
REMARK 610 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 610 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 610 I=INSERTION CODE):
REMARK 610   M RES C SSEQI
REMARK 610     NAG A  710
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 SITE_DESCRIPTION: NAG BINDING SITE FOR RESIDUE A 701
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 SITE_DESCRIPTION: NAG BINDING SITE FOR RESIDUE A 702
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 SITE_DESCRIPTION: NAG BINDING SITE FOR RESIDUE A 710
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 SITE_DESCRIPTION: NAG BINDING SITE FOR RESIDUE B 801
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 SITE_DESCRIPTION: NAG BINDING SITE FOR RESIDUE B 802
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 SITE_DESCRIPTION: BMA BINDING SITE FOR RESIDUE B 803
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 SITE_DESCRIPTION: MAN BINDING SITE FOR RESIDUE B 804
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 SITE_DESCRIPTION: MAN BINDING SITE FOR RESIDUE B 806
REMARK 800 SITE_IDENTIFIER: AC9
REMARK 800 SITE_DESCRIPTION: MAN BINDING SITE FOR RESIDUE B 807
REMARK 800 SITE_IDENTIFIER: BC1
REMARK 800 SITE_DESCRIPTION: NAG BINDING SITE FOR RESIDUE B 810
DBREF  3BL8 A   42   612  UNP    Q69ZK9   NLGN2_MOUSE     42    612
DBREF  3BL8 B   42   612  UNP    Q69ZK9   NLGN2_MOUSE     42    612
DBREF  3BL8 C   42   612  UNP    Q69ZK9   NLGN2_MOUSE     42    612
DBREF  3BL8 D   42   612  UNP    Q69ZK9   NLGN2_MOUSE     42    612
SEQADV 3BL8 GLN A   40  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 LYS A   41  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS A  613  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS A  614  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS A  615  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS A  616  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS A  617  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS A  618  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS A  619  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 GLN B   40  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 LYS B   41  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS B  613  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS B  614  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS B  615  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS B  616  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS B  617  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS B  618  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS B  619  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 GLN C   40  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 LYS C   41  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS C  613  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS C  614  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS C  615  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS C  616  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS C  617  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS C  618  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS C  619  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 GLN D   40  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 LYS D   41  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS D  613  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS D  614  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS D  615  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS D  616  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS D  617  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS D  618  UNP  Q69ZK9              EXPRESSION TAG
SEQADV 3BL8 HIS D  619  UNP  Q69ZK9              EXPRESSION TAG
SEQRES   1 A  580  GLN LYS PRO VAL VAL ASN THR ALA TYR GLY ARG VAL ARG
SEQRES   2 A  580  GLY VAL ARG ARG GLU LEU ASN ASN GLU ILE LEU GLY PRO
SEQRES   3 A  580  VAL VAL GLN PHE LEU GLY VAL PRO TYR ALA THR PRO PRO
SEQRES   4 A  580  LEU GLY ALA ARG ARG PHE GLN PRO PRO GLU ALA PRO ALA
SEQRES   5 A  580  SER TRP PRO GLY VAL ARG ASN ALA THR THR LEU PRO PRO
SEQRES   6 A  580  ALA CYS PRO GLN ASN LEU HIS GLY ALA LEU PRO ALA ILE
SEQRES   7 A  580  MET LEU PRO VAL TRP PHE THR ASP ASN LEU GLU ALA ALA
SEQRES   8 A  580  ALA THR TYR VAL GLN ASN GLN SER GLU ASP CYS LEU TYR
SEQRES   9 A  580  LEU ASN LEU TYR VAL PRO THR GLU ASP GLY PRO LEU THR
SEQRES  10 A  580  LYS LYS ARG ASP GLU ALA THR LEU ASN PRO PRO ASP THR
SEQRES  11 A  580  ASP ILE ARG ASP SER GLY LYS LYS PRO VAL MET LEU PHE
SEQRES  12 A  580  LEU HIS GLY GLY SER TYR MET GLU GLY THR GLY ASN MET
SEQRES  13 A  580  PHE ASP GLY SER VAL LEU ALA ALA TYR GLY ASN VAL ILE
SEQRES  14 A  580  VAL VAL THR LEU ASN TYR ARG LEU GLY VAL LEU GLY PHE
SEQRES  15 A  580  LEU SER THR GLY ASP GLN ALA ALA LYS GLY ASN TYR GLY
SEQRES  16 A  580  LEU LEU ASP GLN ILE GLN ALA LEU ARG TRP LEU SER GLU
SEQRES  17 A  580  ASN ILE ALA HIS PHE GLY GLY ASP PRO GLU ARG ILE THR
SEQRES  18 A  580  ILE PHE GLY SER GLY ALA GLY ALA SER CYS VAL ASN LEU
SEQRES  19 A  580  LEU ILE LEU SER HIS HIS SER GLU GLY LEU PHE GLN LYS
SEQRES  20 A  580  ALA ILE ALA GLN SER GLY THR ALA ILE SER SER TRP SER
SEQRES  21 A  580  VAL ASN TYR GLN PRO LEU LYS TYR THR ARG LEU LEU ALA
SEQRES  22 A  580  ALA LYS VAL GLY CYS ASP ARG GLU ASP SER THR GLU ALA
SEQRES  23 A  580  VAL GLU CYS LEU ARG ARG LYS SER SER ARG GLU LEU VAL
SEQRES  24 A  580  ASP GLN ASP VAL GLN PRO ALA ARG TYR HIS ILE ALA PHE
SEQRES  25 A  580  GLY PRO VAL VAL ASP GLY ASP VAL VAL PRO ASP ASP PRO
SEQRES  26 A  580  GLU ILE LEU MET GLN GLN GLY GLU PHE LEU ASN TYR ASP
SEQRES  27 A  580  MET LEU ILE GLY VAL ASN GLN GLY GLU GLY LEU LYS PHE
SEQRES  28 A  580  VAL GLU ASP SER ALA GLU SER GLU ASP GLY VAL SER ALA
SEQRES  29 A  580  SER ALA PHE ASP PHE THR VAL SER ASN PHE VAL ASP ASN
SEQRES  30 A  580  LEU TYR GLY TYR PRO GLU GLY LYS ASP VAL LEU ARG GLU
SEQRES  31 A  580  THR ILE LYS PHE MET TYR THR ASP TRP ALA ASP ARG ASP
SEQRES  32 A  580  ASN GLY GLU MET ARG ARG LYS THR LEU LEU ALA LEU PHE
SEQRES  33 A  580  THR ASP HIS GLN TRP VAL ALA PRO ALA VAL ALA THR ALA
SEQRES  34 A  580  LYS LEU HIS ALA ASP TYR GLN SER PRO VAL TYR PHE TYR
SEQRES  35 A  580  THR PHE TYR HIS HIS CYS GLN ALA GLU GLY ARG PRO GLU
SEQRES  36 A  580  TRP ALA ASP ALA ALA HIS GLY ASP GLU LEU PRO TYR VAL
SEQRES  37 A  580  PHE GLY VAL PRO MET VAL GLY ALA THR ASP LEU PHE PRO
SEQRES  38 A  580  CYS ASN PHE SER LYS ASN ASP VAL MET LEU SER ALA VAL
SEQRES  39 A  580  VAL MET THR TYR TRP THR ASN PHE ALA LYS THR GLY ASP
SEQRES  40 A  580  PRO ASN GLN PRO VAL PRO GLN ASP THR LYS PHE ILE HIS
SEQRES  41 A  580  THR LYS PRO ASN ARG PHE GLU GLU VAL VAL TRP SER LYS
SEQRES  42 A  580  PHE ASN SER LYS GLU LYS GLN TYR LEU HIS ILE GLY LEU
SEQRES  43 A  580  LYS PRO ARG VAL ARG ASP ASN TYR ARG ALA ASN LYS VAL
SEQRES  44 A  580  ALA PHE TRP LEU GLU LEU VAL PRO HIS LEU HIS ASN LEU
SEQRES  45 A  580  HIS HIS HIS HIS HIS HIS HIS HIS
SEQRES   1 B  580  GLN LYS PRO VAL VAL ASN THR ALA TYR GLY ARG VAL ARG
SEQRES   2 B  580  GLY VAL ARG ARG GLU LEU ASN ASN GLU ILE LEU GLY PRO
SEQRES   3 B  580  VAL VAL GLN PHE LEU GLY VAL PRO TYR ALA THR PRO PRO
SEQRES   4 B  580  LEU GLY ALA ARG ARG PHE GLN PRO PRO GLU ALA PRO ALA
SEQRES   5 B  580  SER TRP PRO GLY VAL ARG ASN ALA THR THR LEU PRO PRO
SEQRES   6 B  580  ALA CYS PRO GLN ASN LEU HIS GLY ALA LEU PRO ALA ILE
SEQRES   7 B  580  MET LEU PRO VAL TRP PHE THR ASP ASN LEU GLU ALA ALA
SEQRES   8 B  580  ALA THR TYR VAL GLN ASN GLN SER GLU ASP CYS LEU TYR
SEQRES   9 B  580  LEU ASN LEU TYR VAL PRO THR GLU ASP GLY PRO LEU THR
SEQRES  10 B  580  LYS LYS ARG ASP GLU ALA THR LEU ASN PRO PRO ASP THR
SEQRES  11 B  580  ASP ILE ARG ASP SER GLY LYS LYS PRO VAL MET LEU PHE
SEQRES  12 B  580  LEU HIS GLY GLY SER TYR MET GLU GLY THR GLY ASN MET
SEQRES  13 B  580  PHE ASP GLY SER VAL LEU ALA ALA TYR GLY ASN VAL ILE
SEQRES  14 B  580  VAL VAL THR LEU ASN TYR ARG LEU GLY VAL LEU GLY PHE
SEQRES  15 B  580  LEU SER THR GLY ASP GLN ALA ALA LYS GLY ASN TYR GLY
SEQRES  16 B  580  LEU LEU ASP GLN ILE GLN ALA LEU ARG TRP LEU SER GLU
SEQRES  17 B  580  ASN ILE ALA HIS PHE GLY GLY ASP PRO GLU ARG ILE THR
SEQRES  18 B  580  ILE PHE GLY SER GLY ALA GLY ALA SER CYS VAL ASN LEU
SEQRES  19 B  580  LEU ILE LEU SER HIS HIS SER GLU GLY LEU PHE GLN LYS
SEQRES  20 B  580  ALA ILE ALA GLN SER GLY THR ALA ILE SER SER TRP SER
SEQRES  21 B  580  VAL ASN TYR GLN PRO LEU LYS TYR THR ARG LEU LEU ALA
SEQRES  22 B  580  ALA LYS VAL GLY CYS ASP ARG GLU ASP SER THR GLU ALA
SEQRES  23 B  580  VAL GLU CYS LEU ARG ARG LYS SER SER ARG GLU LEU VAL
SEQRES  24 B  580  ASP GLN ASP VAL GLN PRO ALA ARG TYR HIS ILE ALA PHE
SEQRES  25 B  580  GLY PRO VAL VAL ASP GLY ASP VAL VAL PRO ASP ASP PRO
SEQRES  26 B  580  GLU ILE LEU MET GLN GLN GLY GLU PHE LEU ASN TYR ASP
SEQRES  27 B  580  MET LEU ILE GLY VAL ASN GLN GLY GLU GLY LEU LYS PHE
SEQRES  28 B  580  VAL GLU ASP SER ALA GLU SER GLU ASP GLY VAL SER ALA
SEQRES  29 B  580  SER ALA PHE ASP PHE THR VAL SER ASN PHE VAL ASP ASN
SEQRES  30 B  580  LEU TYR GLY TYR PRO GLU GLY LYS ASP VAL LEU ARG GLU
SEQRES  31 B  580  THR ILE LYS PHE MET TYR THR ASP TRP ALA ASP ARG ASP
SEQRES  32 B  580  ASN GLY GLU MET ARG ARG LYS THR LEU LEU ALA LEU PHE
SEQRES  33 B  580  THR ASP HIS GLN TRP VAL ALA PRO ALA VAL ALA THR ALA
SEQRES  34 B  580  LYS LEU HIS ALA ASP TYR GLN SER PRO VAL TYR PHE TYR
SEQRES  35 B  580  THR PHE TYR HIS HIS CYS GLN ALA GLU GLY ARG PRO GLU
SEQRES  36 B  580  TRP ALA ASP ALA ALA HIS GLY ASP GLU LEU PRO TYR VAL
SEQRES  37 B  580  PHE GLY VAL PRO MET VAL GLY ALA THR ASP LEU PHE PRO
SEQRES  38 B  580  CYS ASN PHE SER LYS ASN ASP VAL MET LEU SER ALA VAL
SEQRES  39 B  580  VAL MET THR TYR TRP THR ASN PHE ALA LYS THR GLY ASP
SEQRES  40 B  580  PRO ASN GLN PRO VAL PRO GLN ASP THR LYS PHE ILE HIS
SEQRES  41 B  580  THR LYS PRO ASN ARG PHE GLU GLU VAL VAL TRP SER LYS
SEQRES  42 B  580  PHE ASN SER LYS GLU LYS GLN TYR LEU HIS ILE GLY LEU
SEQRES  43 B  580  LYS PRO ARG VAL ARG ASP ASN TYR ARG ALA ASN LYS VAL
SEQRES  44 B  580  ALA PHE TRP LEU GLU LEU VAL PRO HIS LEU HIS ASN LEU
SEQRES  45 B  580  HIS HIS HIS HIS HIS HIS HIS HIS
SEQRES   1 C  580  GLN LYS PRO VAL VAL ASN THR ALA TYR GLY ARG VAL ARG
SEQRES   2 C  580  GLY VAL ARG ARG GLU LEU ASN ASN GLU ILE LEU GLY PRO
SEQRES   3 C  580  VAL VAL GLN PHE LEU GLY VAL PRO TYR ALA THR PRO PRO
SEQRES   4 C  580  LEU GLY ALA ARG ARG PHE GLN PRO PRO GLU ALA PRO ALA
SEQRES   5 C  580  SER TRP PRO GLY VAL ARG ASN ALA THR THR LEU PRO PRO
SEQRES   6 C  580  ALA CYS PRO GLN ASN LEU HIS GLY ALA LEU PRO ALA ILE
SEQRES   7 C  580  MET LEU PRO VAL TRP PHE THR ASP ASN LEU GLU ALA ALA
SEQRES   8 C  580  ALA THR TYR VAL GLN ASN GLN SER GLU ASP CYS LEU TYR
SEQRES   9 C  580  LEU ASN LEU TYR VAL PRO THR GLU ASP GLY PRO LEU THR
SEQRES  10 C  580  LYS LYS ARG ASP GLU ALA THR LEU ASN PRO PRO ASP THR
SEQRES  11 C  580  ASP ILE ARG ASP SER GLY LYS LYS PRO VAL MET LEU PHE
SEQRES  12 C  580  LEU HIS GLY GLY SER TYR MET GLU GLY THR GLY ASN MET
SEQRES  13 C  580  PHE ASP GLY SER VAL LEU ALA ALA TYR GLY ASN VAL ILE
SEQRES  14 C  580  VAL VAL THR LEU ASN TYR ARG LEU GLY VAL LEU GLY PHE
SEQRES  15 C  580  LEU SER THR GLY ASP GLN ALA ALA LYS GLY ASN TYR GLY
SEQRES  16 C  580  LEU LEU ASP GLN ILE GLN ALA LEU ARG TRP LEU SER GLU
SEQRES  17 C  580  ASN ILE ALA HIS PHE GLY GLY ASP PRO GLU ARG ILE THR
SEQRES  18 C  580  ILE PHE GLY SER GLY ALA GLY ALA SER CYS VAL ASN LEU
SEQRES  19 C  580  LEU ILE LEU SER HIS HIS SER GLU GLY LEU PHE GLN LYS
SEQRES  20 C  580  ALA ILE ALA GLN SER GLY THR ALA ILE SER SER TRP SER
SEQRES  21 C  580  VAL ASN TYR GLN PRO LEU LYS TYR THR ARG LEU LEU ALA
SEQRES  22 C  580  ALA LYS VAL GLY CYS ASP ARG GLU ASP SER THR GLU ALA
SEQRES  23 C  580  VAL GLU CYS LEU ARG ARG LYS SER SER ARG GLU LEU VAL
SEQRES  24 C  580  ASP GLN ASP VAL GLN PRO ALA ARG TYR HIS ILE ALA PHE
SEQRES  25 C  580  GLY PRO VAL VAL ASP GLY ASP VAL VAL PRO ASP ASP PRO
SEQRES  26 C  580  GLU ILE LEU MET GLN GLN GLY GLU PHE LEU ASN TYR ASP
SEQRES  27 C  580  MET LEU ILE GLY VAL ASN GLN GLY GLU GLY LEU LYS PHE
SEQRES  28 C  580  VAL GLU ASP SER ALA GLU SER GLU ASP GLY VAL SER ALA
SEQRES  29 C  580  SER ALA PHE ASP PHE THR VAL SER ASN PHE VAL ASP ASN
SEQRES  30 C  580  LEU TYR GLY TYR PRO GLU GLY LYS ASP VAL LEU ARG GLU
SEQRES  31 C  580  THR ILE LYS PHE MET TYR THR ASP TRP ALA ASP ARG ASP
SEQRES  32 C  580  ASN GLY GLU MET ARG ARG LYS THR LEU LEU ALA LEU PHE
SEQRES  33 C  580  THR ASP HIS GLN TRP VAL ALA PRO ALA VAL ALA THR ALA
SEQRES  34 C  580  LYS LEU HIS ALA ASP TYR GLN SER PRO VAL TYR PHE TYR
SEQRES  35 C  580  THR PHE TYR HIS HIS CYS GLN ALA GLU GLY ARG PRO GLU
SEQRES  36 C  580  TRP ALA ASP ALA ALA HIS GLY ASP GLU LEU PRO TYR VAL
SEQRES  37 C  580  PHE GLY VAL PRO MET VAL GLY ALA THR ASP LEU PHE PRO
SEQRES  38 C  580  CYS ASN PHE SER LYS ASN ASP VAL MET LEU SER ALA VAL
SEQRES  39 C  580  VAL MET THR TYR TRP THR ASN PHE ALA LYS THR GLY ASP
SEQRES  40 C  580  PRO ASN GLN PRO VAL PRO GLN ASP THR LYS PHE ILE HIS
SEQRES  41 C  580  THR LYS PRO ASN ARG PHE GLU GLU VAL VAL TRP SER LYS
SEQRES  42 C  580  PHE ASN SER LYS GLU LYS GLN TYR LEU HIS ILE GLY LEU
SEQRES  43 C  580  LYS PRO ARG VAL ARG ASP ASN TYR ARG ALA ASN LYS VAL
SEQRES  44 C  580  ALA PHE TRP LEU GLU LEU VAL PRO HIS LEU HIS ASN LEU
SEQRES  45 C  580  HIS HIS HIS HIS HIS HIS HIS HIS
SEQRES   1 D  580  GLN LYS PRO VAL VAL ASN THR ALA TYR GLY ARG VAL ARG
SEQRES   2 D  580  GLY VAL ARG ARG GLU LEU ASN ASN GLU ILE LEU GLY PRO
SEQRES   3 D  580  VAL VAL GLN PHE LEU GLY VAL PRO TYR ALA THR PRO PRO
SEQRES   4 D  580  LEU GLY ALA ARG ARG PHE GLN PRO PRO GLU ALA PRO ALA
SEQRES   5 D  580  SER TRP PRO GLY VAL ARG ASN ALA THR THR LEU PRO PRO
SEQRES   6 D  580  ALA CYS PRO GLN ASN LEU HIS GLY ALA LEU PRO ALA ILE
SEQRES   7 D  580  MET LEU PRO VAL TRP PHE THR ASP ASN LEU GLU ALA ALA
SEQRES   8 D  580  ALA THR TYR VAL GLN ASN GLN SER GLU ASP CYS LEU TYR
SEQRES   9 D  580  LEU ASN LEU TYR VAL PRO THR GLU ASP GLY PRO LEU THR
SEQRES  10 D  580  LYS LYS ARG ASP GLU ALA THR LEU ASN PRO PRO ASP THR
SEQRES  11 D  580  ASP ILE ARG ASP SER GLY LYS LYS PRO VAL MET LEU PHE
SEQRES  12 D  580  LEU HIS GLY GLY SER TYR MET GLU GLY THR GLY ASN MET
SEQRES  13 D  580  PHE ASP GLY SER VAL LEU ALA ALA TYR GLY ASN VAL ILE
SEQRES  14 D  580  VAL VAL THR LEU ASN TYR ARG LEU GLY VAL LEU GLY PHE
SEQRES  15 D  580  LEU SER THR GLY ASP GLN ALA ALA LYS GLY ASN TYR GLY
SEQRES  16 D  580  LEU LEU ASP GLN ILE GLN ALA LEU ARG TRP LEU SER GLU
SEQRES  17 D  580  ASN ILE ALA HIS PHE GLY GLY ASP PRO GLU ARG ILE THR
SEQRES  18 D  580  ILE PHE GLY SER GLY ALA GLY ALA SER CYS VAL ASN LEU
SEQRES  19 D  580  LEU ILE LEU SER HIS HIS SER GLU GLY LEU PHE GLN LYS
SEQRES  20 D  580  ALA ILE ALA GLN SER GLY THR ALA ILE SER SER TRP SER
SEQRES  21 D  580  VAL ASN TYR GLN PRO LEU LYS TYR THR ARG LEU LEU ALA
SEQRES  22 D  580  ALA LYS VAL GLY CYS ASP ARG GLU ASP SER THR GLU ALA
SEQRES  23 D  580  VAL GLU CYS LEU ARG ARG LYS SER SER ARG GLU LEU VAL
SEQRES  24 D  580  ASP GLN ASP VAL GLN PRO ALA ARG TYR HIS ILE ALA PHE
SEQRES  25 D  580  GLY PRO VAL VAL ASP GLY ASP VAL VAL PRO ASP ASP PRO
SEQRES  26 D  580  GLU ILE LEU MET GLN GLN GLY GLU PHE LEU ASN TYR ASP
SEQRES  27 D  580  MET LEU ILE GLY VAL ASN GLN GLY GLU GLY LEU LYS PHE
SEQRES  28 D  580  VAL GLU ASP SER ALA GLU SER GLU ASP GLY VAL SER ALA
SEQRES  29 D  580  SER ALA PHE ASP PHE THR VAL SER ASN PHE VAL ASP ASN
SEQRES  30 D  580  LEU TYR GLY TYR PRO GLU GLY LYS ASP VAL LEU ARG GLU
SEQRES  31 D  580  THR ILE LYS PHE MET TYR THR ASP TRP ALA ASP ARG ASP
SEQRES  32 D  580  ASN GLY GLU MET ARG ARG LYS THR LEU LEU ALA LEU PHE
SEQRES  33 D  580  THR ASP HIS GLN TRP VAL ALA PRO ALA VAL ALA THR ALA
SEQRES  34 D  580  LYS LEU HIS ALA ASP TYR GLN SER PRO VAL TYR PHE TYR
SEQRES  35 D  580  THR PHE TYR HIS HIS CYS GLN ALA GLU GLY ARG PRO GLU
SEQRES  36 D  580  TRP ALA ASP ALA ALA HIS GLY ASP GLU LEU PRO TYR VAL
SEQRES  37 D  580  PHE GLY VAL PRO MET VAL GLY ALA THR ASP LEU PHE PRO
SEQRES  38 D  580  CYS ASN PHE SER LYS ASN ASP VAL MET LEU SER ALA VAL
SEQRES  39 D  580  VAL MET THR TYR TRP THR ASN PHE ALA LYS THR GLY ASP
SEQRES  40 D  580  PRO ASN GLN PRO VAL PRO GLN ASP THR LYS PHE ILE HIS
SEQRES  41 D  580  THR LYS PRO ASN ARG PHE GLU GLU VAL VAL TRP SER LYS
SEQRES  42 D  580  PHE ASN SER LYS GLU LYS GLN TYR LEU HIS ILE GLY LEU
SEQRES  43 D  580  LYS PRO ARG VAL ARG ASP ASN TYR ARG ALA ASN LYS VAL
SEQRES  44 D  580  ALA PHE TRP LEU GLU LEU VAL PRO HIS LEU HIS ASN LEU
SEQRES  45 D  580  HIS HIS HIS HIS HIS HIS HIS HIS
MODRES 3BL8 ASN A   98  ASN  GLYCOSYLATION SITE
MODRES 3BL8 ASN B   98  ASN  GLYCOSYLATION SITE
MODRES 3BL8 ASN B  136  ASN  GLYCOSYLATION SITE
HET    NAG  A 701      14
HET    NAG  A 702      14
HET    MAN  A 703      11
HET    NAG  A 710      14
HET    NAG  B 801      14
HET    NAG  B 802      14
HET    BMA  B 803      11
HET    MAN  B 804      11
HET    MAN  B 806      11
HET    MAN  B 805      11
HET    MAN  B 807      11
HET    NAG  B 810      14
HETNAM     NAG N-ACETYL-D-GLUCOSAMINE
HETNAM     MAN ALPHA-D-MANNOSE
HETNAM     BMA BETA-D-MANNOSE
HETSYN     NAG NAG
FORMUL   5  NAG    6(C8 H15 N O6)
FORMUL   5  MAN    5(C6 H12 O6)
FORMUL   7  BMA    C6 H12 O6
FORMUL   9  HOH   *52(H2 O)
HELIX    1   1 PRO A  120  ASN A  126  1                                   7
HELIX    2   2 ASN A  126  THR A  132  1                                   7
HELIX    3   3 TYR A  133  GLN A  135  5                                   3
HELIX    4   4 THR A  192  PHE A  196  5                                   5
HELIX    5   5 GLY A  198  ASN A  206  1                                   9
HELIX    6   6 LEU A  216  LEU A  222  1                                   7
HELIX    7   7 ASN A  232  ILE A  249  1                                  18
HELIX    8   8 ALA A  250  PHE A  252  5                                   3
HELIX    9   9 GLY A  265  SER A  277  1                                  13
HELIX   10  10 GLN A  303  GLY A  316  1                                  14
HELIX   11  11 ASP A  321  ARG A  330  1                                  10
HELIX   12  12 SER A  333  ASP A  339  1                                   7
HELIX   13  13 ASP A  363  GLY A  371  1                                   9
HELIX   14  14 LYS A  389  ALA A  395  5                                   7
HELIX   15  15 SER A  402  LEU A  417  1                                  16
HELIX   16  16 GLY A  423  THR A  436  1                                  14
HELIX   17  17 ASN A  443  TRP A  460  1                                  18
HELIX   18  18 TRP A  460  TYR A  474  1                                  15
HELIX   19  19 GLU A  503  GLY A  509  1                                   7
HELIX   20  20 GLY A  509  GLY A  514  1                                   6
HELIX   21  21 SER A  524  GLY A  545  1                                  22
HELIX   22  22 ASN A  563  GLU A  567  5                                   5
HELIX   23  23 ARG A  594  GLU A  603  1                                  10
HELIX   24  24 VAL A  605  HIS A  609  5                                   5
HELIX   25  25 PRO B  120  ASN B  126  1                                   7
HELIX   26  26 ASN B  126  THR B  132  1                                   7
HELIX   27  27 GLY B  198  TYR B  204  1                                   7
HELIX   28  28 LEU B  216  PHE B  221  1                                   6
HELIX   29  29 ASN B  232  ILE B  249  1                                  18
HELIX   30  30 ALA B  250  PHE B  252  5                                   3
HELIX   31  31 GLY B  265  SER B  277  1                                  13
HELIX   32  32 GLN B  303  GLY B  316  1                                  14
HELIX   33  33 ASP B  321  ARG B  330  1                                  10
HELIX   34  34 SER B  333  ASP B  339  1                                   7
HELIX   35  35 ASP B  363  GLN B  370  1                                   8
HELIX   36  36 GLY B  387  ALA B  395  5                                   9
HELIX   37  37 PHE B  406  ASN B  416  1                                  11
HELIX   38  38 TYR B  420  LYS B  424  5                                   5
HELIX   39  39 ASP B  425  TYR B  435  1                                  11
HELIX   40  40 GLU B  445  TRP B  460  1                                  16
HELIX   41  41 TRP B  460  TYR B  474  1                                  15
HELIX   42  42 GLU B  503  PHE B  508  1                                   6
HELIX   43  43 SER B  524  GLY B  545  1                                  22
HELIX   44  44 ARG B  594  GLU B  603  1                                  10
HELIX   45  45 LEU B  604  LEU B  608  5                                   5
HELIX   46  46 LEU C   79  ARG C   83  5                                   5
HELIX   47  47 PRO C  120  ASN C  126  1                                   7
HELIX   48  48 ASN C  126  ALA C  131  1                                   6
HELIX   49  49 THR C  132  GLN C  135  5                                   4
HELIX   50  50 THR C  192  PHE C  196  5                                   5
HELIX   51  51 GLY C  198  ASN C  206  1                                   9
HELIX   52  52 ASN C  232  ILE C  249  1                                  18
HELIX   53  53 ALA C  250  PHE C  252  5                                   3
HELIX   54  54 GLY C  265  SER C  277  1                                  13
HELIX   55  55 GLN C  303  GLY C  316  1                                  14
HELIX   56  56 ASP C  321  ARG C  330  1                                  10
HELIX   57  57 SER C  333  ASP C  339  1                                   7
HELIX   58  58 ASP C  363  GLY C  371  1                                   9
HELIX   59  59 GLY C  387  GLU C  392  5                                   6
HELIX   60  60 SER C  402  TYR C  418  1                                  17
HELIX   61  61 GLU C  422  TYR C  435  1                                  14
HELIX   62  62 GLY C  444  TRP C  460  1                                  17
HELIX   63  63 TRP C  460  TYR C  474  1                                  15
HELIX   64  64 GLU C  503  PHE C  508  1                                   6
HELIX   65  65 SER C  524  GLY C  545  1                                  22
HELIX   66  66 ARG C  594  GLU C  603  1                                  10
HELIX   67  67 GLU C  603  LEU C  608  1                                   6
HELIX   68  68 PRO D  120  ASN D  126  1                                   7
HELIX   69  69 ASN D  126  VAL D  134  1                                   9
HELIX   70  70 THR D  192  PHE D  196  5                                   5
HELIX   71  71 ASP D  197  ASN D  206  1                                  10
HELIX   72  72 LEU D  216  GLY D  220  5                                   5
HELIX   73  73 ASN D  232  ILE D  249  1                                  18
HELIX   74  74 GLY D  265  LEU D  276  1                                  12
HELIX   75  75 SER D  296  VAL D  300  5                                   5
HELIX   76  76 GLN D  303  GLY D  316  1                                  14
HELIX   77  77 ASP D  321  ARG D  330  1                                  10
HELIX   78  78 SER D  333  ASP D  339  1                                   7
HELIX   79  79 ASP D  363  GLN D  370  1                                   8
HELIX   80  80 GLY D  387  VAL D  391  5                                   5
HELIX   81  81 SER D  402  TYR D  418  1                                  17
HELIX   82  82 GLY D  423  TYR D  435  1                                  13
HELIX   83  83 GLY D  444  TRP D  460  1                                  17
HELIX   84  84 TRP D  460  ASP D  473  1                                  14
HELIX   85  85 GLU D  503  GLY D  509  1                                   7
HELIX   86  86 SER D  524  GLY D  545  1                                  22
HELIX   87  87 ARG D  594  GLU D  603  1                                  10
HELIX   88  88 VAL D  605  HIS D  609  5                                   5
SHEET    1   A 2 ARG A  50  VAL A  51  0
SHEET    2   A 2 VAL A  96  ARG A  97  1  O  ARG A  97   N  ARG A  50
SHEET    1   B11 ARG A  55  ARG A  56  0
SHEET    2   B11 VAL A  66  PRO A  73 -1  O  VAL A  66   N  ARG A  56
SHEET    3   B11 TYR A 143  PRO A 149 -1  O  VAL A 148   N  VAL A  67
SHEET    4   B11 ILE A 208  LEU A 212 -1  O  THR A 211   N  ASN A 145
SHEET    5   B11 LYS A 177  LEU A 183  1  N  PRO A 178   O  ILE A 208
SHEET    6   B11 GLY A 254  SER A 264  1  O  ASP A 255   N  LYS A 177
SHEET    7   B11 LYS A 286  GLN A 290  1  O  LYS A 286   N  ILE A 261
SHEET    8   B11 ASP A 377  ASN A 383  1  O  LEU A 379   N  ALA A 289
SHEET    9   B11 VAL A 478  TYR A 484  1  O  PHE A 483   N  VAL A 382
SHEET   10   B11 GLN A 579  GLY A 584  1  O  ILE A 583   N  TYR A 484
SHEET   11   B11 VAL A 589  ASP A 591 -1  O  ARG A 590   N  TYR A 580
SHEET    1   C 3 VAL B  43  THR B  46  0
SHEET    2   C 3 GLY B  49  ARG B  52 -1  O  VAL B  51   N  VAL B  44
SHEET    3   C 3 VAL B  96  ASN B  98  1  O  ARG B  97   N  ARG B  50
SHEET    1   D11 VAL B  54  ARG B  56  0
SHEET    2   D11 VAL B  66  PRO B  73 -1  O  GLN B  68   N  VAL B  54
SHEET    3   D11 TYR B 143  PRO B 149 -1  O  LEU B 146   N  PHE B  69
SHEET    4   D11 ILE B 208  LEU B 212 -1  O  THR B 211   N  ASN B 145
SHEET    5   D11 LYS B 177  LEU B 183  1  N  MET B 180   O  VAL B 210
SHEET    6   D11 GLY B 254  SER B 264  1  O  THR B 260   N  VAL B 179
SHEET    7   D11 LYS B 286  GLN B 290  1  O  GLN B 290   N  GLY B 263
SHEET    8   D11 ASP B 377  ASN B 383  1  O  ASP B 377   N  ALA B 287
SHEET    9   D11 VAL B 478  TYR B 484  1  O  TYR B 479   N  MET B 378
SHEET   10   D11 TYR B 580  GLY B 584  1  O  ILE B 583   N  TYR B 484
SHEET   11   D11 ARG B 588  ARG B 590 -1  O  ARG B 590   N  TYR B 580
SHEET    1   E 2 VAL C  43  THR C  46  0
SHEET    2   E 2 GLY C  49  ARG C  52 -1  O  GLY C  49   N  THR C  46
SHEET    1   F 3 VAL C  54  GLU C  57  0
SHEET    2   F 3 PRO C  65  PRO C  73 -1  O  GLN C  68   N  VAL C  54
SHEET    3   F 3 TYR C 143  PRO C 149 -1  O  LEU C 146   N  PHE C  69
SHEET    1   G 8 ILE C 208  VAL C 210  0
SHEET    2   G 8 LYS C 177  LEU C 183  1  N  MET C 180   O  ILE C 208
SHEET    3   G 8 GLY C 254  SER C 264  1  O  THR C 260   N  VAL C 179
SHEET    4   G 8 LYS C 286  GLN C 290  1  O  GLN C 290   N  GLY C 263
SHEET    5   G 8 ASP C 377  ASN C 383  1  O  ASP C 377   N  ALA C 287
SHEET    6   G 8 VAL C 478  PHE C 483  1  O  PHE C 483   N  VAL C 382
SHEET    7   G 8 TYR C 580  ILE C 583  1  O  LEU C 581   N  PHE C 480
SHEET    8   G 8 ARG C 588  ARG C 590 -1  O  ARG C 588   N  HIS C 582
SHEET    1   H 3 VAL D  43  ASN D  45  0
SHEET    2   H 3 ARG D  50  ARG D  52 -1  O  VAL D  51   N  VAL D  44
SHEET    3   H 3 VAL D  96  ASN D  98  1  O  ARG D  97   N  ARG D  52
SHEET    1   I11 VAL D  54  ARG D  56  0
SHEET    2   I11 VAL D  66  PRO D  73 -1  O  GLN D  68   N  VAL D  54
SHEET    3   I11 TYR D 143  PRO D 149 -1  O  LEU D 146   N  PHE D  69
SHEET    4   I11 ILE D 208  THR D 211 -1  O  THR D 211   N  ASN D 145
SHEET    5   I11 LYS D 177  LEU D 183  1  N  MET D 180   O  VAL D 210
SHEET    6   I11 GLY D 254  GLY D 263  1  O  THR D 260   N  VAL D 179
SHEET    7   I11 LYS D 286  GLN D 290  1  O  ILE D 288   N  ILE D 261
SHEET    8   I11 ASP D 377  ASN D 383  1  O  LEU D 379   N  ALA D 289
SHEET    9   I11 VAL D 478  TYR D 484  1  O  TYR D 481   N  ILE D 380
SHEET   10   I11 TYR D 580  GLY D 584  1  O  LEU D 581   N  PHE D 480
SHEET   11   I11 VAL D 589  ARG D 590 -1  O  ARG D 590   N  TYR D 580
SSBOND   1 CYS A  106    CYS A  141                        1555   1555    2.03
SSBOND   2 CYS A  317    CYS A  328                        1555   1555    2.06
SSBOND   3 CYS A  487    CYS A  521                        1555   1555    2.06
SSBOND   4 CYS B  106    CYS B  141                        1555   1555    2.03
SSBOND   5 CYS B  317    CYS B  328                        1555   1555    2.04
SSBOND   6 CYS B  487    CYS B  521                        1555   1555    2.04
SSBOND   7 CYS C  106    CYS C  141                        1555   1555    2.04
SSBOND   8 CYS C  317    CYS C  328                        1555   1555    2.05
SSBOND   9 CYS C  487    CYS C  521                        1555   1555    2.04
SSBOND  10 CYS D  106    CYS D  141                        1555   1555    2.03
SSBOND  11 CYS D  317    CYS D  328                        1555   1555    2.03
SSBOND  12 CYS D  487    CYS D  521                        1555   1555    2.04
LINK         ND2 ASN A  98                 C1  NAG A 701   1555   1555    1.44
LINK         ND2 ASN B  98                 C1  NAG B 801   1555   1555    1.39
LINK         ND2 ASN B 136                 C1  NAG B 810   1555   1555    1.45
LINK         O4  NAG A 701                 C1  NAG A 702   1555   1555    1.44
LINK         O4  NAG A 702                 C1  MAN A 703   1555   1555    1.47
LINK         O4  NAG B 801                 C1  NAG B 802   1555   1555    1.44
LINK         O4  NAG B 802                 C1  BMA B 803   1555   1555    1.46
LINK         O3  BMA B 803                 C1  MAN B 806   1555   1555    1.44
LINK         O6  BMA B 803                 C1  MAN B 804   1555   1555    1.43
LINK         O3  MAN B 806                 C1  MAN B 807   1555   1555    1.45
LINK         O6  MAN B 806                 C1  MAN B 805   1555   1555    1.46
CISPEP   1 GLN B  549    PRO B  550          0        24.68
SITE     1 AC1  5 LYS A  41  ARG A  52  ASN A  98  ASN A 574
SITE     2 AC1  5 LYS A 576
SITE     1 AC2  2 ARG A  52  LYS A 576
SITE     1 AC3  3 THR A 132  TYR A 133  ASN A 136
SITE     1 AC4  5 LYS A 230  ASP A 356  GLY A 357  ASP A 358
SITE     2 AC4  5 ASN B  98
SITE     1 AC5  3 GLY A 225  LYS A 230  ASP A 356
SITE     1 AC7  5 THR A 224  GLY A 225  GLN A 303  PRO A 304
SITE     2 AC7  5 LEU A 305
SITE     1 AC8  1 ASP A 362
SITE     1 AC9  2 TYR A 302  ASP A 363
SITE     1 BC1  2 ASN B 136  HOH B 812
CRYST1  214.723   92.567  188.408  90.00  98.36  90.00 C 1 2 1      16
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.004657  0.000000  0.000684        0.00000
SCALE2      0.000000  0.010803  0.000000        0.00000
SCALE3      0.000000  0.000000  0.005365        0.00000
TER    4359      HIS A 609
TER    8643      LEU B 608
TER   12926      ASN C 610
TER   17176      ASN D 610
MASTER      733    0   12   88   54    0   12    617374    4  177  180
END