longtext: 3DD5-pdb

content
HEADER    HYDROLASE                               05-JUN-08   3DD5
TITLE     GLOMERELLA CINGULATA E600-CUTINASE COMPLEX
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: CUTINASE;
COMPND   3 CHAIN: A, B, C, D, E, F, G, H;
COMPND   4 FRAGMENT: RESIDUES 31-224;
COMPND   5 SYNONYM: CUTIN HYDROLASE;
COMPND   6 EC: 3.1.1.74;
COMPND   7 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: GLOMERELLA CINGULATA;
SOURCE   3 ORGANISM_COMMON: ANTHRACNOSE FUNGUS;
SOURCE   4 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   5 EXPRESSION_SYSTEM_STRAIN: ORIGAMI (DE3);
SOURCE   6 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE   7 EXPRESSION_SYSTEM_PLASMID: PET32B_CUTA
KEYWDS    CATALYTIC TRIAD, HYDROLASE, SECRETED, SERINE ESTERASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    M.P.NYON,D.W.RICE,J.M.BERRISFORD,A.M.HOUNSLOW,A.J.G.MOIR,
AUTHOR   2 H.HUANG,S.NATHAN,N.M.MAHADI,A.B.FARAH DIBA,C.J.CRAVEN
REVDAT   1   18-NOV-08 3DD5    0
JRNL        AUTH   M.P.NYON,D.W.RICE,J.M.BERRISFORD,A.M.HOUNSLOW,
JRNL        AUTH 2 A.J.G.MOIR,H.HUANG,S.NATHAN,N.M.MAHADI,F.D.A.BAKAR,
JRNL        AUTH 3 C.J.CRAVEN
JRNL        TITL   CATALYSIS BY GLOMERELLA CINGULATA CUTINASE
JRNL        TITL 2 REQUIRES CONFORMATIONAL CYCLING BETWEEN THE ACTIVE
JRNL        TITL 3 AND INACTIVE STATES OF ITS CATALYTIC TRIAD
JRNL        REF    J.MOL.BIOL.                                2008
JRNL        REFN   ASTM JMOBAK  UK ESSN 1089-8638
REMARK   1
REMARK   2
REMARK   2 RESOLUTION. 2.60 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.2.0019
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3    REFINEMENT TARGET : NULL
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.60
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 19.80
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.0
REMARK   3   NUMBER OF REFLECTIONS             : 44886
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.219
REMARK   3   R VALUE            (WORKING SET) : 0.215
REMARK   3   FREE R VALUE                     : 0.279
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.100
REMARK   3   FREE R VALUE TEST SET COUNT      : 2391
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH           : 2.60
REMARK   3   BIN RESOLUTION RANGE LOW            : 2.67
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 3108
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 94.67
REMARK   3   BIN R VALUE           (WORKING SET) : 0.3100
REMARK   3   BIN FREE R VALUE SET COUNT          : 196
REMARK   3   BIN FREE R VALUE                    : 0.4020
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   ALL ATOMS                : 11496
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 40.34
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 20.30
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -0.01000
REMARK   3    B22 (A**2) : 0.01000
REMARK   3    B33 (A**2) : -0.01000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : -0.02000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.603
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.376
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.278
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 13.040
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.898
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.828
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A): 11716 ; 0.013 ; 0.022
REMARK   3   BOND LENGTHS OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 15936 ; 1.477 ; 1.963
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  1539 ; 6.931 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   459 ;41.183 ;24.074
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  1764 ;19.376 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    64 ;21.690 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  1831 ; 0.107 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  8884 ; 0.005 ; 0.020
REMARK   3   GENERAL PLANES OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  5458 ; 0.231 ; 0.200
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  8088 ; 0.313 ; 0.200
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):   389 ; 0.166 ; 0.200
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):   112 ; 0.196 ; 0.200
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):     9 ; 0.225 ; 0.200
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 3DD5 COMPLIES WITH FORMAT V. 3.1, 01-AUG-2007
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ.
REMARK 100 THE RCSB ID CODE IS RCSB047889.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 10-AUG-2006
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : NULL
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : N
REMARK 200  RADIATION SOURCE               : ROTATING ANODE
REMARK 200  BEAMLINE                       : NULL
REMARK 200  X-RAY GENERATOR MODEL          : RIGAKU MICROMAX-007
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.5418
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : OSMIC VARIMAX
REMARK 200
REMARK 200  DETECTOR TYPE                  : IMAGE PLATE
REMARK 200  DETECTOR MANUFACTURER          : MAR SCANNER 345 MM PLATE
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : MOSFLM
REMARK 200  DATA SCALING SOFTWARE          : SCALA
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 47279
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.600
REMARK 200  RESOLUTION RANGE LOW       (A) : 20.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.0
REMARK 200  DATA REDUNDANCY                : 2.900
REMARK 200  R MERGE                    (I) : 0.12200
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 9.4000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.60
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.74
REMARK 200  COMPLETENESS FOR SHELL     (%) : 95.9
REMARK 200  DATA REDUNDANCY IN SHELL       : 2.40
REMARK 200  R MERGE FOR SHELL          (I) : 0.41600
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 2.300
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: PDB ENTRY 3DCN
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 48.00
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.37
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1M MAGNESIUM ACETATE, 18% PEG
REMARK 280  3350, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 290K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,1/2+Y,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       58.68500
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 3
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 4
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 5
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: E
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 6
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: F
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 7
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: G
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 8
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: H
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 9
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 4620 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 28960 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -50.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1 -1.000000  0.000000  0.000000      -22.34646
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000      -58.68500
REMARK 350   BIOMT3   1  0.000000  0.000000 -1.000000       92.58128
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C
REMARK 350   BIOMT1   2 -1.000000  0.000000  0.000000       51.12354
REMARK 350   BIOMT2   2  0.000000  1.000000  0.000000      -58.68500
REMARK 350   BIOMT3   2  0.000000  0.000000 -1.000000       92.58128
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, F
REMARK 350   BIOMT1   3  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   3  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   3  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 10
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 4590 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 28970 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -48.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350 APPLY THE FOLLOWING TO CHAINS: G
REMARK 350   BIOMT1   2  1.000000  0.000000  0.000000      -51.12354
REMARK 350   BIOMT2   2  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   2  0.000000  0.000000  1.000000      -92.58128
REMARK 350 APPLY THE FOLLOWING TO CHAINS: E
REMARK 350   BIOMT1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   3  0.000000  1.000000  0.000000      -58.68500
REMARK 350   BIOMT3   3  0.000000  0.000000 -1.000000        0.00000
REMARK 350 APPLY THE FOLLOWING TO CHAINS: H
REMARK 350   BIOMT1   4 -1.000000  0.000000  0.000000      -73.47000
REMARK 350   BIOMT2   4  0.000000  1.000000  0.000000      -58.68500
REMARK 350   BIOMT3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 11
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 1310 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 15520 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -12.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   2 -1.000000  0.000000  0.000000      -22.34646
REMARK 350   BIOMT2   2  0.000000  1.000000  0.000000      -58.68500
REMARK 350   BIOMT3   2  0.000000  0.000000 -1.000000       92.58128
REMARK 350
REMARK 350 BIOMOLECULE: 12
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 1360 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 15390 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -14.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350 APPLY THE FOLLOWING TO CHAINS: F
REMARK 350   BIOMT1   2 -1.000000  0.000000  0.000000       51.12354
REMARK 350   BIOMT2   2  0.000000  1.000000  0.000000       58.68500
REMARK 350   BIOMT3   2  0.000000  0.000000 -1.000000       92.58128
REMARK 350
REMARK 350 BIOMOLECULE: 13
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 1360 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 15590 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -11.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350 APPLY THE FOLLOWING TO CHAINS: E
REMARK 350   BIOMT1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   2  0.000000  1.000000  0.000000      -58.68500
REMARK 350   BIOMT3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 14
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 1320 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 15270 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -13.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: G
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350 APPLY THE FOLLOWING TO CHAINS: H
REMARK 350   BIOMT1   2 -1.000000  0.000000  0.000000      -22.34646
REMARK 350   BIOMT2   2  0.000000  1.000000  0.000000      -58.68500
REMARK 350   BIOMT3   2  0.000000  0.000000 -1.000000       92.58128
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C  SSEQI
REMARK 465     ALA A    24
REMARK 465     MET A    25
REMARK 465     ALA A    26
REMARK 465     ILE A    27
REMARK 465     SER A    28
REMARK 465     ASP A    29
REMARK 465     PRO A    30
REMARK 465     ALA B    24
REMARK 465     MET B    25
REMARK 465     ALA B    26
REMARK 465     ILE B    27
REMARK 465     SER B    28
REMARK 465     ASP B    29
REMARK 465     PRO B    30
REMARK 465     ALA C    24
REMARK 465     MET C    25
REMARK 465     ALA C    26
REMARK 465     ILE C    27
REMARK 465     SER C    28
REMARK 465     ASP C    29
REMARK 465     PRO C    30
REMARK 465     GLN C    31
REMARK 465     ALA D    24
REMARK 465     MET D    25
REMARK 465     ALA D    26
REMARK 465     ILE D    27
REMARK 465     SER D    28
REMARK 465     ASP D    29
REMARK 465     PRO D    30
REMARK 465     ALA E    24
REMARK 465     MET E    25
REMARK 465     ALA E    26
REMARK 465     ILE E    27
REMARK 465     SER E    28
REMARK 465     ASP E    29
REMARK 465     PRO E    30
REMARK 465     GLN E    31
REMARK 465     ALA F    24
REMARK 465     MET F    25
REMARK 465     ALA F    26
REMARK 465     ILE F    27
REMARK 465     SER F    28
REMARK 465     ASP F    29
REMARK 465     PRO F    30
REMARK 465     GLN F    31
REMARK 465     ALA G    24
REMARK 465     MET G    25
REMARK 465     ALA G    26
REMARK 465     ILE G    27
REMARK 465     SER G    28
REMARK 465     ASP G    29
REMARK 465     PRO G    30
REMARK 465     GLN G    31
REMARK 465     ALA H    24
REMARK 465     MET H    25
REMARK 465     ALA H    26
REMARK 465     ILE H    27
REMARK 465     SER H    28
REMARK 465     ASP H    29
REMARK 465     PRO H    30
REMARK 465     GLN H    31
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS(M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     THR A  58    OG1
REMARK 470     GLY A 224    C    O
REMARK 470     THR G  58    CG2
REMARK 470     THR H  40    CG2
REMARK 470     THR H  58    OG1
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    ARG D 174   NE  -  CZ  -  NH1 ANGL. DEV. =   3.5 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    THR A  58      -23.20     97.38
REMARK 500    SER A  66     -111.36   -112.46
REMARK 500    SER A 136     -118.21     57.77
REMARK 500    VAL A 213      -73.24   -114.15
REMARK 500    SER B  43        1.05    -63.33
REMARK 500    THR B  58      -25.51     85.38
REMARK 500    SER B  66      -92.43   -111.09
REMARK 500    PRO B  92        1.56    -65.52
REMARK 500    CYS B 125       88.66   -153.17
REMARK 500    SER B 136     -118.72     62.80
REMARK 500    TYR B 165      104.10    -56.38
REMARK 500    HIS B 204     -177.47   -170.93
REMARK 500    VAL B 213      -59.37   -124.60
REMARK 500    SER C  43        2.92    -69.72
REMARK 500    ALA C  45       63.83   -109.77
REMARK 500    THR C  58      -23.53     86.82
REMARK 500    SER C  66     -105.03   -125.22
REMARK 500    PRO C  92      -37.53    -39.89
REMARK 500    TYR C  93       94.76    -65.18
REMARK 500    SER C 136     -106.19     63.40
REMARK 500    LEU C 201      128.29    173.32
REMARK 500    SER D  32       20.30    -76.68
REMARK 500    THR D  58      -23.23     73.38
REMARK 500    SER D  66     -105.21   -110.48
REMARK 500    SER D 136     -110.87     68.73
REMARK 500    THR D 197     -166.77   -129.35
REMARK 500    ILE D 200       70.36     85.86
REMARK 500    LEU D 201      115.81    172.36
REMARK 500    ALA E  45       61.39   -154.67
REMARK 500    SER E  66     -101.18   -142.77
REMARK 500    ASN E  82       22.35    -64.90
REMARK 500    ASP E  83       11.73   -157.53
REMARK 500    SER E 136     -120.41     62.33
REMARK 500    SER E 147      -15.08    -44.89
REMARK 500    SER E 150      161.43    -47.46
REMARK 500    PRO E 176      130.21    -34.49
REMARK 500    PRO E 202      131.85    -37.52
REMARK 500    ALA F  45       49.69   -156.97
REMARK 500    SER F  66     -124.76   -117.26
REMARK 500    VAL F  89       93.48    -69.87
REMARK 500    PRO F  92       -6.67    -59.01
REMARK 500    SER F 136     -115.70     64.14
REMARK 500    SER F 147      -34.29    -38.46
REMARK 500    LYS F 167       36.27    -93.39
REMARK 500    SER G  44       24.72    -67.22
REMARK 500    ALA G  45       56.29   -170.75
REMARK 500    THR G  58      -24.52     68.79
REMARK 500    SER G  66      -97.63   -125.32
REMARK 500    THR G 106     -166.29   -171.40
REMARK 500    SER G 136     -113.89     65.39
REMARK 500    LEU G 172       35.28     76.70
REMARK 500    VAL G 213      -69.99   -121.02
REMARK 500    ALA H  45       58.03   -142.12
REMARK 500    THR H  58      -19.11     75.99
REMARK 500    SER H  66      -99.26   -124.13
REMARK 500    PRO H  92        5.90    -60.60
REMARK 500    SER H 136     -109.66     72.10
REMARK 500    GLU H 179      118.38    -27.44
REMARK 500    ASP H 191       91.72    -56.64
REMARK 500    ALA H 203       60.56     99.97
REMARK 500    VAL H 213      -58.96   -122.88
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500                                 MODEL     OMEGA
REMARK 500 ALA G  203     HIS G  204                 -149.85
REMARK 500
REMARK 500 REMARK: NULL
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE DEP A 401
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE DEP B 402
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE DEP C 403
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE DEP D 404
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE DEP E 405
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE DEP F 406
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE DEP G 407
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE DEP H 408
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 3DCN   RELATED DB: PDB
REMARK 900 APO CUTINASE
REMARK 900 RELATED ID: 3DEA   RELATED DB: PDB
REMARK 900 PETFP-CUTINASE COMPLEX
REMARK 999
REMARK 999 SEQUENCE
REMARK 999 THE SEQUENCE IS BASED ON REFERENCE 2 IN THE DATABASE,
REMARK 999 CUTI_COLGL.
DBREF  3DD5 A   31   224  UNP    P11373   CUTI_COLGL      31    224
DBREF  3DD5 B   31   224  UNP    P11373   CUTI_COLGL      31    224
DBREF  3DD5 C   31   224  UNP    P11373   CUTI_COLGL      31    224
DBREF  3DD5 D   31   224  UNP    P11373   CUTI_COLGL      31    224
DBREF  3DD5 E   31   224  UNP    P11373   CUTI_COLGL      31    224
DBREF  3DD5 F   31   224  UNP    P11373   CUTI_COLGL      31    224
DBREF  3DD5 G   31   224  UNP    P11373   CUTI_COLGL      31    224
DBREF  3DD5 H   31   224  UNP    P11373   CUTI_COLGL      31    224
SEQADV 3DD5 ALA A   24  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 MET A   25  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ALA A   26  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ILE A   27  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 SER A   28  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ASP A   29  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 PRO A   30  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ALA B   24  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 MET B   25  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ALA B   26  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ILE B   27  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 SER B   28  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ASP B   29  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 PRO B   30  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ALA C   24  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 MET C   25  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ALA C   26  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ILE C   27  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 SER C   28  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ASP C   29  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 PRO C   30  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ALA D   24  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 MET D   25  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ALA D   26  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ILE D   27  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 SER D   28  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ASP D   29  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 PRO D   30  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ALA E   24  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 MET E   25  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ALA E   26  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ILE E   27  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 SER E   28  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ASP E   29  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 PRO E   30  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ALA F   24  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 MET F   25  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ALA F   26  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ILE F   27  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 SER F   28  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ASP F   29  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 PRO F   30  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ALA G   24  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 MET G   25  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ALA G   26  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ILE G   27  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 SER G   28  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ASP G   29  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 PRO G   30  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ALA H   24  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 MET H   25  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ALA H   26  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ILE H   27  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 SER H   28  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 ASP H   29  UNP  P11373              EXPRESSION TAG
SEQADV 3DD5 PRO H   30  UNP  P11373              EXPRESSION TAG
SEQRES   1 A  201  ALA MET ALA ILE SER ASP PRO GLN SER SER THR ARG ASN
SEQRES   2 A  201  GLU LEU GLU THR GLY SER SER SER ALA CYS PRO LYS VAL
SEQRES   3 A  201  ILE TYR ILE PHE ALA ARG ALA SER THR GLU PRO GLY ASN
SEQRES   4 A  201  MET GLY ILE SER ALA GLY PRO ILE VAL ALA ASP ALA LEU
SEQRES   5 A  201  GLU ARG ILE TYR GLY ALA ASN ASP VAL TRP VAL GLN GLY
SEQRES   6 A  201  VAL GLY GLY PRO TYR LEU ALA ASP LEU ALA SER ASN PHE
SEQRES   7 A  201  LEU PRO ASP GLY THR SER SER ALA ALA ILE ASN GLU ALA
SEQRES   8 A  201  ARG ARG LEU PHE THR LEU ALA ASN THR LYS CYS PRO ASN
SEQRES   9 A  201  ALA ALA ILE VAL SER GLY GLY TYR SER GLN GLY THR ALA
SEQRES  10 A  201  VAL MET ALA GLY SER ILE SER GLY LEU SER THR THR ILE
SEQRES  11 A  201  LYS ASN GLN ILE LYS GLY VAL VAL LEU PHE GLY TYR THR
SEQRES  12 A  201  LYS ASN LEU GLN ASN LEU GLY ARG ILE PRO ASN PHE GLU
SEQRES  13 A  201  THR SER LYS THR GLU VAL TYR CYS ASP ILE ALA ASP ALA
SEQRES  14 A  201  VAL CYS TYR GLY THR LEU PHE ILE LEU PRO ALA HIS PHE
SEQRES  15 A  201  LEU TYR GLN THR ASP ALA ALA VAL ALA ALA PRO ARG PHE
SEQRES  16 A  201  LEU GLN ALA ARG ILE GLY
SEQRES   1 B  201  ALA MET ALA ILE SER ASP PRO GLN SER SER THR ARG ASN
SEQRES   2 B  201  GLU LEU GLU THR GLY SER SER SER ALA CYS PRO LYS VAL
SEQRES   3 B  201  ILE TYR ILE PHE ALA ARG ALA SER THR GLU PRO GLY ASN
SEQRES   4 B  201  MET GLY ILE SER ALA GLY PRO ILE VAL ALA ASP ALA LEU
SEQRES   5 B  201  GLU ARG ILE TYR GLY ALA ASN ASP VAL TRP VAL GLN GLY
SEQRES   6 B  201  VAL GLY GLY PRO TYR LEU ALA ASP LEU ALA SER ASN PHE
SEQRES   7 B  201  LEU PRO ASP GLY THR SER SER ALA ALA ILE ASN GLU ALA
SEQRES   8 B  201  ARG ARG LEU PHE THR LEU ALA ASN THR LYS CYS PRO ASN
SEQRES   9 B  201  ALA ALA ILE VAL SER GLY GLY TYR SER GLN GLY THR ALA
SEQRES  10 B  201  VAL MET ALA GLY SER ILE SER GLY LEU SER THR THR ILE
SEQRES  11 B  201  LYS ASN GLN ILE LYS GLY VAL VAL LEU PHE GLY TYR THR
SEQRES  12 B  201  LYS ASN LEU GLN ASN LEU GLY ARG ILE PRO ASN PHE GLU
SEQRES  13 B  201  THR SER LYS THR GLU VAL TYR CYS ASP ILE ALA ASP ALA
SEQRES  14 B  201  VAL CYS TYR GLY THR LEU PHE ILE LEU PRO ALA HIS PHE
SEQRES  15 B  201  LEU TYR GLN THR ASP ALA ALA VAL ALA ALA PRO ARG PHE
SEQRES  16 B  201  LEU GLN ALA ARG ILE GLY
SEQRES   1 C  201  ALA MET ALA ILE SER ASP PRO GLN SER SER THR ARG ASN
SEQRES   2 C  201  GLU LEU GLU THR GLY SER SER SER ALA CYS PRO LYS VAL
SEQRES   3 C  201  ILE TYR ILE PHE ALA ARG ALA SER THR GLU PRO GLY ASN
SEQRES   4 C  201  MET GLY ILE SER ALA GLY PRO ILE VAL ALA ASP ALA LEU
SEQRES   5 C  201  GLU ARG ILE TYR GLY ALA ASN ASP VAL TRP VAL GLN GLY
SEQRES   6 C  201  VAL GLY GLY PRO TYR LEU ALA ASP LEU ALA SER ASN PHE
SEQRES   7 C  201  LEU PRO ASP GLY THR SER SER ALA ALA ILE ASN GLU ALA
SEQRES   8 C  201  ARG ARG LEU PHE THR LEU ALA ASN THR LYS CYS PRO ASN
SEQRES   9 C  201  ALA ALA ILE VAL SER GLY GLY TYR SER GLN GLY THR ALA
SEQRES  10 C  201  VAL MET ALA GLY SER ILE SER GLY LEU SER THR THR ILE
SEQRES  11 C  201  LYS ASN GLN ILE LYS GLY VAL VAL LEU PHE GLY TYR THR
SEQRES  12 C  201  LYS ASN LEU GLN ASN LEU GLY ARG ILE PRO ASN PHE GLU
SEQRES  13 C  201  THR SER LYS THR GLU VAL TYR CYS ASP ILE ALA ASP ALA
SEQRES  14 C  201  VAL CYS TYR GLY THR LEU PHE ILE LEU PRO ALA HIS PHE
SEQRES  15 C  201  LEU TYR GLN THR ASP ALA ALA VAL ALA ALA PRO ARG PHE
SEQRES  16 C  201  LEU GLN ALA ARG ILE GLY
SEQRES   1 D  201  ALA MET ALA ILE SER ASP PRO GLN SER SER THR ARG ASN
SEQRES   2 D  201  GLU LEU GLU THR GLY SER SER SER ALA CYS PRO LYS VAL
SEQRES   3 D  201  ILE TYR ILE PHE ALA ARG ALA SER THR GLU PRO GLY ASN
SEQRES   4 D  201  MET GLY ILE SER ALA GLY PRO ILE VAL ALA ASP ALA LEU
SEQRES   5 D  201  GLU ARG ILE TYR GLY ALA ASN ASP VAL TRP VAL GLN GLY
SEQRES   6 D  201  VAL GLY GLY PRO TYR LEU ALA ASP LEU ALA SER ASN PHE
SEQRES   7 D  201  LEU PRO ASP GLY THR SER SER ALA ALA ILE ASN GLU ALA
SEQRES   8 D  201  ARG ARG LEU PHE THR LEU ALA ASN THR LYS CYS PRO ASN
SEQRES   9 D  201  ALA ALA ILE VAL SER GLY GLY TYR SER GLN GLY THR ALA
SEQRES  10 D  201  VAL MET ALA GLY SER ILE SER GLY LEU SER THR THR ILE
SEQRES  11 D  201  LYS ASN GLN ILE LYS GLY VAL VAL LEU PHE GLY TYR THR
SEQRES  12 D  201  LYS ASN LEU GLN ASN LEU GLY ARG ILE PRO ASN PHE GLU
SEQRES  13 D  201  THR SER LYS THR GLU VAL TYR CYS ASP ILE ALA ASP ALA
SEQRES  14 D  201  VAL CYS TYR GLY THR LEU PHE ILE LEU PRO ALA HIS PHE
SEQRES  15 D  201  LEU TYR GLN THR ASP ALA ALA VAL ALA ALA PRO ARG PHE
SEQRES  16 D  201  LEU GLN ALA ARG ILE GLY
SEQRES   1 E  201  ALA MET ALA ILE SER ASP PRO GLN SER SER THR ARG ASN
SEQRES   2 E  201  GLU LEU GLU THR GLY SER SER SER ALA CYS PRO LYS VAL
SEQRES   3 E  201  ILE TYR ILE PHE ALA ARG ALA SER THR GLU PRO GLY ASN
SEQRES   4 E  201  MET GLY ILE SER ALA GLY PRO ILE VAL ALA ASP ALA LEU
SEQRES   5 E  201  GLU ARG ILE TYR GLY ALA ASN ASP VAL TRP VAL GLN GLY
SEQRES   6 E  201  VAL GLY GLY PRO TYR LEU ALA ASP LEU ALA SER ASN PHE
SEQRES   7 E  201  LEU PRO ASP GLY THR SER SER ALA ALA ILE ASN GLU ALA
SEQRES   8 E  201  ARG ARG LEU PHE THR LEU ALA ASN THR LYS CYS PRO ASN
SEQRES   9 E  201  ALA ALA ILE VAL SER GLY GLY TYR SER GLN GLY THR ALA
SEQRES  10 E  201  VAL MET ALA GLY SER ILE SER GLY LEU SER THR THR ILE
SEQRES  11 E  201  LYS ASN GLN ILE LYS GLY VAL VAL LEU PHE GLY TYR THR
SEQRES  12 E  201  LYS ASN LEU GLN ASN LEU GLY ARG ILE PRO ASN PHE GLU
SEQRES  13 E  201  THR SER LYS THR GLU VAL TYR CYS ASP ILE ALA ASP ALA
SEQRES  14 E  201  VAL CYS TYR GLY THR LEU PHE ILE LEU PRO ALA HIS PHE
SEQRES  15 E  201  LEU TYR GLN THR ASP ALA ALA VAL ALA ALA PRO ARG PHE
SEQRES  16 E  201  LEU GLN ALA ARG ILE GLY
SEQRES   1 F  201  ALA MET ALA ILE SER ASP PRO GLN SER SER THR ARG ASN
SEQRES   2 F  201  GLU LEU GLU THR GLY SER SER SER ALA CYS PRO LYS VAL
SEQRES   3 F  201  ILE TYR ILE PHE ALA ARG ALA SER THR GLU PRO GLY ASN
SEQRES   4 F  201  MET GLY ILE SER ALA GLY PRO ILE VAL ALA ASP ALA LEU
SEQRES   5 F  201  GLU ARG ILE TYR GLY ALA ASN ASP VAL TRP VAL GLN GLY
SEQRES   6 F  201  VAL GLY GLY PRO TYR LEU ALA ASP LEU ALA SER ASN PHE
SEQRES   7 F  201  LEU PRO ASP GLY THR SER SER ALA ALA ILE ASN GLU ALA
SEQRES   8 F  201  ARG ARG LEU PHE THR LEU ALA ASN THR LYS CYS PRO ASN
SEQRES   9 F  201  ALA ALA ILE VAL SER GLY GLY TYR SER GLN GLY THR ALA
SEQRES  10 F  201  VAL MET ALA GLY SER ILE SER GLY LEU SER THR THR ILE
SEQRES  11 F  201  LYS ASN GLN ILE LYS GLY VAL VAL LEU PHE GLY TYR THR
SEQRES  12 F  201  LYS ASN LEU GLN ASN LEU GLY ARG ILE PRO ASN PHE GLU
SEQRES  13 F  201  THR SER LYS THR GLU VAL TYR CYS ASP ILE ALA ASP ALA
SEQRES  14 F  201  VAL CYS TYR GLY THR LEU PHE ILE LEU PRO ALA HIS PHE
SEQRES  15 F  201  LEU TYR GLN THR ASP ALA ALA VAL ALA ALA PRO ARG PHE
SEQRES  16 F  201  LEU GLN ALA ARG ILE GLY
SEQRES   1 G  201  ALA MET ALA ILE SER ASP PRO GLN SER SER THR ARG ASN
SEQRES   2 G  201  GLU LEU GLU THR GLY SER SER SER ALA CYS PRO LYS VAL
SEQRES   3 G  201  ILE TYR ILE PHE ALA ARG ALA SER THR GLU PRO GLY ASN
SEQRES   4 G  201  MET GLY ILE SER ALA GLY PRO ILE VAL ALA ASP ALA LEU
SEQRES   5 G  201  GLU ARG ILE TYR GLY ALA ASN ASP VAL TRP VAL GLN GLY
SEQRES   6 G  201  VAL GLY GLY PRO TYR LEU ALA ASP LEU ALA SER ASN PHE
SEQRES   7 G  201  LEU PRO ASP GLY THR SER SER ALA ALA ILE ASN GLU ALA
SEQRES   8 G  201  ARG ARG LEU PHE THR LEU ALA ASN THR LYS CYS PRO ASN
SEQRES   9 G  201  ALA ALA ILE VAL SER GLY GLY TYR SER GLN GLY THR ALA
SEQRES  10 G  201  VAL MET ALA GLY SER ILE SER GLY LEU SER THR THR ILE
SEQRES  11 G  201  LYS ASN GLN ILE LYS GLY VAL VAL LEU PHE GLY TYR THR
SEQRES  12 G  201  LYS ASN LEU GLN ASN LEU GLY ARG ILE PRO ASN PHE GLU
SEQRES  13 G  201  THR SER LYS THR GLU VAL TYR CYS ASP ILE ALA ASP ALA
SEQRES  14 G  201  VAL CYS TYR GLY THR LEU PHE ILE LEU PRO ALA HIS PHE
SEQRES  15 G  201  LEU TYR GLN THR ASP ALA ALA VAL ALA ALA PRO ARG PHE
SEQRES  16 G  201  LEU GLN ALA ARG ILE GLY
SEQRES   1 H  201  ALA MET ALA ILE SER ASP PRO GLN SER SER THR ARG ASN
SEQRES   2 H  201  GLU LEU GLU THR GLY SER SER SER ALA CYS PRO LYS VAL
SEQRES   3 H  201  ILE TYR ILE PHE ALA ARG ALA SER THR GLU PRO GLY ASN
SEQRES   4 H  201  MET GLY ILE SER ALA GLY PRO ILE VAL ALA ASP ALA LEU
SEQRES   5 H  201  GLU ARG ILE TYR GLY ALA ASN ASP VAL TRP VAL GLN GLY
SEQRES   6 H  201  VAL GLY GLY PRO TYR LEU ALA ASP LEU ALA SER ASN PHE
SEQRES   7 H  201  LEU PRO ASP GLY THR SER SER ALA ALA ILE ASN GLU ALA
SEQRES   8 H  201  ARG ARG LEU PHE THR LEU ALA ASN THR LYS CYS PRO ASN
SEQRES   9 H  201  ALA ALA ILE VAL SER GLY GLY TYR SER GLN GLY THR ALA
SEQRES  10 H  201  VAL MET ALA GLY SER ILE SER GLY LEU SER THR THR ILE
SEQRES  11 H  201  LYS ASN GLN ILE LYS GLY VAL VAL LEU PHE GLY TYR THR
SEQRES  12 H  201  LYS ASN LEU GLN ASN LEU GLY ARG ILE PRO ASN PHE GLU
SEQRES  13 H  201  THR SER LYS THR GLU VAL TYR CYS ASP ILE ALA ASP ALA
SEQRES  14 H  201  VAL CYS TYR GLY THR LEU PHE ILE LEU PRO ALA HIS PHE
SEQRES  15 H  201  LEU TYR GLN THR ASP ALA ALA VAL ALA ALA PRO ARG PHE
SEQRES  16 H  201  LEU GLN ALA ARG ILE GLY
HET    DEP  A 401       8
HET    DEP  B 402       8
HET    DEP  C 403       8
HET    DEP  D 404       8
HET    DEP  E 405       8
HET    DEP  F 406       8
HET    DEP  G 407       8
HET    DEP  H 408       8
HETNAM     DEP DIETHYL PHOSPHONATE
FORMUL   9  DEP    8(C4 H11 O3 P)
FORMUL  17  HOH   *4(H2 O)
HELIX    1   1 SER A   66  GLY A   80  1                                  15
HELIX    2   2 ASP A   96  LEU A  102  5                                   7
HELIX    3   3 SER A  107  CYS A  125  1                                  19
HELIX    4   4 SER A  136  GLY A  148  1                                  13
HELIX    5   5 SER A  150  ASN A  155  1                                   6
HELIX    6   6 LYS A  167  LEU A  172  1                                   6
HELIX    7   7 GLU A  179  SER A  181  5                                   3
HELIX    8   8 ASP A  191  GLY A  196  5                                   6
HELIX    9   9 TYR A  207  VAL A  213  1                                   7
HELIX   10  10 VAL A  213  ILE A  223  1                                  11
HELIX   11  11 SER B   66  GLY B   80  1                                  15
HELIX   12  12 LEU B   97  LEU B  102  5                                   6
HELIX   13  13 SER B  107  CYS B  125  1                                  19
HELIX   14  14 SER B  136  SER B  147  1                                  12
HELIX   15  15 SER B  150  ASN B  155  1                                   6
HELIX   16  16 GLU B  179  SER B  181  5                                   3
HELIX   17  17 ASP B  191  GLY B  196  5                                   6
HELIX   18  18 TYR B  207  VAL B  213  1                                   7
HELIX   19  19 VAL B  213  GLY B  224  1                                  12
HELIX   20  20 ASN C   36  GLY C   41  1                                   6
HELIX   21  21 SER C   66  GLY C   80  1                                  15
HELIX   22  22 ASP C   96  LEU C  102  5                                   7
HELIX   23  23 SER C  107  CYS C  125  1                                  19
HELIX   24  24 GLN C  137  GLY C  148  1                                  12
HELIX   25  25 SER C  150  GLN C  156  1                                   7
HELIX   26  26 GLU C  179  SER C  181  5                                   3
HELIX   27  27 ASP C  191  GLY C  196  5                                   6
HELIX   28  28 TYR C  207  VAL C  213  1                                   7
HELIX   29  29 VAL C  213  GLY C  224  1                                  12
HELIX   30  30 SER D   66  GLY D   80  1                                  15
HELIX   31  31 ASP D   96  LEU D  102  5                                   7
HELIX   32  32 SER D  107  CYS D  125  1                                  19
HELIX   33  33 SER D  136  GLY D  148  1                                  13
HELIX   34  34 SER D  150  ASN D  155  1                                   6
HELIX   35  35 ASP D  191  GLY D  196  5                                   6
HELIX   36  36 TYR D  207  VAL D  213  1                                   7
HELIX   37  37 VAL D  213  GLY D  224  1                                  12
HELIX   38  38 ASN E   36  GLY E   41  1                                   6
HELIX   39  39 SER E   66  GLY E   80  1                                  15
HELIX   40  40 LEU E   97  LEU E  102  5                                   6
HELIX   41  41 SER E  107  CYS E  125  1                                  19
HELIX   42  42 SER E  136  SER E  147  1                                  12
HELIX   43  43 SER E  150  GLN E  156  1                                   7
HELIX   44  44 GLU E  179  SER E  181  5                                   3
HELIX   45  45 ASP E  191  GLY E  196  5                                   6
HELIX   46  46 TYR E  207  VAL E  213  1                                   7
HELIX   47  47 VAL E  213  GLY E  224  1                                  12
HELIX   48  48 ASN F   36  GLY F   41  1                                   6
HELIX   49  49 SER F   66  GLY F   80  1                                  15
HELIX   50  50 LEU F   97  LEU F  102  5                                   6
HELIX   51  51 SER F  107  CYS F  125  1                                  19
HELIX   52  52 SER F  136  GLY F  148  1                                  13
HELIX   53  53 SER F  150  GLN F  156  1                                   7
HELIX   54  54 GLU F  179  SER F  181  5                                   3
HELIX   55  55 ASP F  191  GLY F  196  5                                   6
HELIX   56  56 TYR F  207  VAL F  213  1                                   7
HELIX   57  57 VAL F  213  GLY F  224  1                                  12
HELIX   58  58 SER G   42  CYS G   46  5                                   5
HELIX   59  59 SER G   66  GLY G   80  1                                  15
HELIX   60  60 ASP G   96  LEU G  102  5                                   7
HELIX   61  61 SER G  107  CYS G  125  1                                  19
HELIX   62  62 GLN G  137  SER G  147  1                                  11
HELIX   63  63 SER G  150  GLN G  156  1                                   7
HELIX   64  64 LYS G  167  LEU G  172  1                                   6
HELIX   65  65 ASP G  191  TYR G  195  5                                   5
HELIX   66  66 TYR G  207  VAL G  213  1                                   7
HELIX   67  67 VAL G  213  GLY G  224  1                                  12
HELIX   68  68 ASN H   36  GLY H   41  1                                   6
HELIX   69  69 SER H   66  GLY H   80  1                                  15
HELIX   70  70 ASP H   96  LEU H  102  5                                   7
HELIX   71  71 SER H  107  CYS H  125  1                                  19
HELIX   72  72 SER H  136  SER H  147  1                                  12
HELIX   73  73 SER H  150  GLN H  156  1                                   7
HELIX   74  74 GLU H  179  SER H  181  5                                   3
HELIX   75  75 ASP H  191  TYR H  195  5                                   5
HELIX   76  76 TYR H  207  VAL H  213  1                                   7
HELIX   77  77 VAL H  213  GLY H  224  1                                  12
SHEET    1   A 5 VAL A  84  GLY A  88  0
SHEET    2   A 5 VAL A  49  ALA A  54  1  N  TYR A  51   O  TRP A  85
SHEET    3   A 5 ALA A 129  TYR A 135  1  O  VAL A 131   N  ILE A  50
SHEET    4   A 5 ILE A 157  PHE A 163  1  O  LYS A 158   N  ILE A 130
SHEET    5   A 5 THR A 183  TYR A 186  1  O  TYR A 186   N  LEU A 162
SHEET    1   B 5 VAL B  84  GLY B  88  0
SHEET    2   B 5 VAL B  49  ALA B  54  1  N  TYR B  51   O  GLN B  87
SHEET    3   B 5 ALA B 129  TYR B 135  1  O  VAL B 131   N  ILE B  50
SHEET    4   B 5 ILE B 157  PHE B 163  1  O  PHE B 163   N  GLY B 134
SHEET    5   B 5 THR B 183  TYR B 186  1  O  TYR B 186   N  LEU B 162
SHEET    1   C 5 VAL C  84  GLY C  88  0
SHEET    2   C 5 VAL C  49  ALA C  54  1  N  TYR C  51   O  GLN C  87
SHEET    3   C 5 ALA C 129  TYR C 135  1  O  ALA C 129   N  ILE C  50
SHEET    4   C 5 ILE C 157  PHE C 163  1  O  LYS C 158   N  ILE C 130
SHEET    5   C 5 THR C 183  TYR C 186  1  O  TYR C 186   N  LEU C 162
SHEET    1   D 5 VAL D  84  GLY D  88  0
SHEET    2   D 5 VAL D  49  ALA D  54  1  N  TYR D  51   O  TRP D  85
SHEET    3   D 5 ALA D 129  TYR D 135  1  O  ALA D 129   N  ILE D  50
SHEET    4   D 5 ILE D 157  PHE D 163  1  O  LYS D 158   N  ILE D 130
SHEET    5   D 5 THR D 183  TYR D 186  1  O  TYR D 186   N  LEU D 162
SHEET    1   E 5 VAL E  84  GLY E  88  0
SHEET    2   E 5 VAL E  49  ALA E  54  1  N  TYR E  51   O  TRP E  85
SHEET    3   E 5 ALA E 129  TYR E 135  1  O  VAL E 131   N  ILE E  50
SHEET    4   E 5 ILE E 157  PHE E 163  1  O  PHE E 163   N  GLY E 134
SHEET    5   E 5 THR E 183  TYR E 186  1  O  TYR E 186   N  LEU E 162
SHEET    1   F 5 VAL F  84  GLY F  88  0
SHEET    2   F 5 VAL F  49  ALA F  54  1  N  TYR F  51   O  GLN F  87
SHEET    3   F 5 ALA F 129  TYR F 135  1  O  VAL F 131   N  ILE F  50
SHEET    4   F 5 ILE F 157  PHE F 163  1  O  LYS F 158   N  ILE F 130
SHEET    5   F 5 THR F 183  TYR F 186  1  O  TYR F 186   N  LEU F 162
SHEET    1   G 5 VAL G  84  GLY G  88  0
SHEET    2   G 5 VAL G  49  ALA G  54  1  N  TYR G  51   O  GLN G  87
SHEET    3   G 5 ALA G 129  TYR G 135  1  O  ALA G 129   N  ILE G  50
SHEET    4   G 5 ILE G 157  PHE G 163  1  O  PHE G 163   N  GLY G 134
SHEET    5   G 5 THR G 183  TYR G 186  1  O  GLU G 184   N  LEU G 162
SHEET    1   H 5 VAL H  84  GLY H  88  0
SHEET    2   H 5 VAL H  49  ALA H  54  1  N  TYR H  51   O  TRP H  85
SHEET    3   H 5 ALA H 129  TYR H 135  1  O  ALA H 129   N  ILE H  50
SHEET    4   H 5 ILE H 157  PHE H 163  1  O  PHE H 163   N  GLY H 134
SHEET    5   H 5 THR H 183  TYR H 186  1  O  TYR H 186   N  LEU H 162
SSBOND   1 CYS A   46    CYS A  125                        1555   1555    2.06
SSBOND   2 CYS A  187    CYS A  194                        1555   1555    2.10
SSBOND   3 CYS B   46    CYS B  125                        1555   1555    2.05
SSBOND   4 CYS B  187    CYS B  194                        1555   1555    2.13
SSBOND   5 CYS C   46    CYS C  125                        1555   1555    2.07
SSBOND   6 CYS C  187    CYS C  194                        1555   1555    2.10
SSBOND   7 CYS D   46    CYS D  125                        1555   1555    2.06
SSBOND   8 CYS D  187    CYS D  194                        1555   1555    2.09
SSBOND   9 CYS E   46    CYS E  125                        1555   1555    2.07
SSBOND  10 CYS E  187    CYS E  194                        1555   1555    2.09
SSBOND  11 CYS F   46    CYS F  125                        1555   1555    2.09
SSBOND  12 CYS F  187    CYS F  194                        1555   1555    2.11
SSBOND  13 CYS G   46    CYS G  125                        1555   1555    2.06
SSBOND  14 CYS G  187    CYS G  194                        1555   1555    2.13
SSBOND  15 CYS H   46    CYS H  125                        1555   1555    2.07
SSBOND  16 CYS H  187    CYS H  194                        1555   1555    2.10
LINK         OG  SER A 136                 P   DEP A 401   1555   1555    1.87
LINK         OG  SER B 136                 P   DEP B 402   1555   1555    1.91
LINK         OG  SER C 136                 P   DEP C 403   1555   1555    1.83
LINK         OG  SER D 136                 P   DEP D 404   1555   1555    2.00
LINK         OG  SER E 136                 P   DEP E 405   1555   1555    1.93
LINK         OG  SER F 136                 P   DEP F 406   1555   1555    1.74
LINK         OG  SER G 136                 P   DEP G 407   1555   1555    2.19
LINK         OG  SER H 136                 P   DEP H 408   1555   1555    1.73
CISPEP   1 ILE A  223    GLY A  224          0         0.65
CISPEP   2 PHE D  199    ILE D  200          0        -8.02
CISPEP   3 TYR G  195    GLY G  196          0       -16.87
CISPEP   4 PRO H  202    ALA H  203          0        -6.48
SITE     1 AC1  5 ALA A  56  SER A  57  ASN A 100  SER A 136
SITE     2 AC1  5 GLN A 137
SITE     1 AC2  4 SER B  57  ASN B 100  SER B 136  GLN B 137
SITE     1 AC3  5 ALA C  56  SER C  57  SER C 136  GLN C 137
SITE     2 AC3  5 PHE C 199
SITE     1 AC4  8 ALA D  56  SER D  57  ASN D 100  TYR D 135
SITE     2 AC4  8 SER D 136  GLN D 137  VAL D 193  PHE D 199
SITE     1 AC5  7 ALA E  56  SER E  57  ASN E 100  TYR E 135
SITE     2 AC5  7 SER E 136  GLN E 137  VAL E 193
SITE     1 AC6  8 ALA F  56  SER F  57  ASN F 100  TYR F 135
SITE     2 AC6  8 SER F 136  GLN F 137  VAL F 193  LEU F 198
SITE     1 AC7  7 ALA G  56  SER G  57  ASN G 100  TYR G 135
SITE     2 AC7  7 SER G 136  GLN G 137  LEU G 201
SITE     1 AC8  7 ALA H  56  SER H  57  TYR H 135  SER H 136
SITE     2 AC8  7 GLN H 137  VAL H 193  PHE H 199
CRYST1   73.470  117.370   95.240  90.00 103.57  90.00 P 1 21 1     16
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.013610  0.000000  0.003286        0.00000
SCALE2      0.000000  0.008520  0.000000        0.00000
SCALE3      0.000000  0.000000  0.010801        0.00000
TER    1432      GLY A 224
TER    2868      GLY B 224
TER    4295      GLY C 224
TER    5731      GLY D 224
TER    7158      GLY E 224
TER    8585      GLY F 224
TER   10011      GLY G 224
TER   11436      GLY H 224
MASTER      584    0    8   77   40    0   15    611496    8  104  128
END