longtext: 3DOH-pdb

content
HEADER    HYDROLASE                               04-JUL-08   3DOH
TITLE     CRYSTAL STRUCTURE OF A THERMOSTABLE ESTERASE
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: ESTERASE;
COMPND   3 CHAIN: A, B;
COMPND   4 FRAGMENT: RESIDUES 16-395;
COMPND   5 EC: 3.1.1.1;
COMPND   6 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: THERMOTOGA MARITIMA;
SOURCE   3 ORGANISM_TAXID: 2336;
SOURCE   4 STRAIN: MSB8;
SOURCE   5 GENE: TM_0033;
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PET-24D
KEYWDS    ALPHA-BETA HYDROLASE, BETA SHEET
EXPDTA    X-RAY DIFFRACTION
AUTHOR    M.LEVISSON,L.SUN,S.HENDRIKS,B.W.DIJKSTRA,J.VAN DER OOST,
AUTHOR   2 S.W.M.KENGEN
REVDAT   1   17-FEB-09 3DOH    0
JRNL        AUTH   M.LEVISSON,L.SUN,S.HENDRIKS,P.SWINKELS,T.AKVELD,
JRNL        AUTH 2 J.B.BULTEMA,A.BARENDREGT,R.H.H.VAN DEN HEUVEL,
JRNL        AUTH 3 B.W.DIJKSTRA,J.VAN DER OOST,S.W.M.KENGEN
JRNL        TITL   CRYSTAL STRUCTURE AND BIOCHEMICAL PROPERTIES OF A
JRNL        TITL 2 NOVEL THERMOSTABLE ESTERASE CONTAINING AN
JRNL        TITL 3 IMMUNOGLOBULIN-LIKE DOMAIN.
JRNL        REF    J.MOL.BIOL.                   V. 385   949 2009
JRNL        REFN                   ISSN 0022-2836
JRNL        PMID   19013466
JRNL        DOI    10.1016/J.JMB.2008.10.075
REMARK   1
REMARK   2
REMARK   2 RESOLUTION.    2.60 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.2.0019
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.60
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 19.96
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000
REMARK   3   COMPLETENESS FOR RANGE        (%) : 96.4
REMARK   3   NUMBER OF REFLECTIONS             : 28373
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.200
REMARK   3   R VALUE            (WORKING SET) : 0.197
REMARK   3   FREE R VALUE                     : 0.268
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000
REMARK   3   FREE R VALUE TEST SET COUNT      : 1506
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.60
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.67
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 2092
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 98.47
REMARK   3   BIN R VALUE           (WORKING SET) : 0.3120
REMARK   3   BIN FREE R VALUE SET COUNT          : 98
REMARK   3   BIN FREE R VALUE                    : 0.3550
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 5982
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 50
REMARK   3   SOLVENT ATOMS            : 156
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 37.12
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : 0.01000
REMARK   3    B22 (A**2) : 0.01000
REMARK   3    B33 (A**2) : -0.01000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.693
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.335
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.245
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 11.516
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.947
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.898
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  6185 ; 0.018 ; 0.022
REMARK   3   BOND LENGTHS OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES):  8427 ; 1.887 ; 1.964
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):   745 ;10.304 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   286 ;35.953 ;24.476
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  1011 ;20.566 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    29 ;19.916 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):   918 ; 0.135 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  4719 ; 0.006 ; 0.020
REMARK   3   GENERAL PLANES OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  3016 ; 0.247 ; 0.200
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  4127 ; 0.329 ; 0.200
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):   323 ; 0.163 ; 0.200
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):    70 ; 0.285 ; 0.200
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):    10 ; 0.077 ; 0.200
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  3841 ; 0.931 ; 1.500
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  6111 ; 1.639 ; 2.000
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  2706 ; 2.007 ; 3.000
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  2316 ; 3.242 ; 4.500
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : BABINET MODEL WITH MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 3DOH COMPLIES WITH FORMAT V. 3.20, 01-DEC-08
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 08-JUL-08.
REMARK 100 THE RCSB ID CODE IS RCSB048291.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 07-MAR-07
REMARK 200  TEMPERATURE           (KELVIN) : 100.0
REMARK 200  PH                             : 7.0
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : ESRF
REMARK 200  BEAMLINE                       : ID29
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.0000, 0.9791, 0.9793, 0.9757
REMARK 200  MONOCHROMATOR                  : SI(111) MONOCHROMATOR
REMARK 200  OPTICS                         : MIRRORS
REMARK 200
REMARK 200  DETECTOR TYPE                  : AREA DETECTOR
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 315
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : MOSFLM
REMARK 200  DATA SCALING SOFTWARE          : SCALA
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 31079
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.600
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 0.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 100.0
REMARK 200  DATA REDUNDANCY                : 5.600
REMARK 200  R MERGE                    (I) : 0.08700
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 14.2000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.60
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.74
REMARK 200  COMPLETENESS FOR SHELL     (%) : 100.0
REMARK 200  DATA REDUNDANCY IN SHELL       : 5.70
REMARK 200  R MERGE FOR SHELL          (I) : 0.43000
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 3.600
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: MAD
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MAD
REMARK 200 SOFTWARE USED: SHELXS
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 57.55
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.90
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 20% PEG 8000, 1M LITHIUM SULPHATE
REMARK 280  MONOHYDRATE, PH 7.0, VAPOR DIFFUSION, HANGING DROP,
REMARK 280  TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: H 3 2
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -Y,X-Y,Z
REMARK 290       3555   -X+Y,-X,Z
REMARK 290       4555   Y,X,-Z
REMARK 290       5555   X-Y,-Y,-Z
REMARK 290       6555   -X,-X+Y,-Z
REMARK 290       7555   X+2/3,Y+1/3,Z+1/3
REMARK 290       8555   -Y+2/3,X-Y+1/3,Z+1/3
REMARK 290       9555   -X+Y+2/3,-X+1/3,Z+1/3
REMARK 290      10555   Y+2/3,X+1/3,-Z+1/3
REMARK 290      11555   X-Y+2/3,-Y+1/3,-Z+1/3
REMARK 290      12555   -X+2/3,-X+Y+1/3,-Z+1/3
REMARK 290      13555   X+1/3,Y+2/3,Z+2/3
REMARK 290      14555   -Y+1/3,X-Y+2/3,Z+2/3
REMARK 290      15555   -X+Y+1/3,-X+2/3,Z+2/3
REMARK 290      16555   Y+1/3,X+2/3,-Z+2/3
REMARK 290      17555   X-Y+1/3,-Y+2/3,-Z+2/3
REMARK 290      18555   -X+1/3,-X+Y+2/3,-Z+2/3
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -0.500000 -0.866025  0.000000        0.00000
REMARK 290   SMTRY2   2  0.866025 -0.500000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   3 -0.500000  0.866025  0.000000        0.00000
REMARK 290   SMTRY2   3 -0.866025 -0.500000  0.000000        0.00000
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   4 -0.500000  0.866025  0.000000        0.00000
REMARK 290   SMTRY2   4  0.866025  0.500000  0.000000        0.00000
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   5  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   5  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   5  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   6 -0.500000 -0.866025  0.000000        0.00000
REMARK 290   SMTRY2   6 -0.866025  0.500000  0.000000        0.00000
REMARK 290   SMTRY3   6  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   7  1.000000  0.000000  0.000000       65.07850
REMARK 290   SMTRY2   7  0.000000  1.000000  0.000000       37.57309
REMARK 290   SMTRY3   7  0.000000  0.000000  1.000000      102.06133
REMARK 290   SMTRY1   8 -0.500000 -0.866025  0.000000       65.07850
REMARK 290   SMTRY2   8  0.866025 -0.500000  0.000000       37.57309
REMARK 290   SMTRY3   8  0.000000  0.000000  1.000000      102.06133
REMARK 290   SMTRY1   9 -0.500000  0.866025  0.000000       65.07850
REMARK 290   SMTRY2   9 -0.866025 -0.500000  0.000000       37.57309
REMARK 290   SMTRY3   9  0.000000  0.000000  1.000000      102.06133
REMARK 290   SMTRY1  10 -0.500000  0.866025  0.000000       65.07850
REMARK 290   SMTRY2  10  0.866025  0.500000  0.000000       37.57309
REMARK 290   SMTRY3  10  0.000000  0.000000 -1.000000      102.06133
REMARK 290   SMTRY1  11  1.000000  0.000000  0.000000       65.07850
REMARK 290   SMTRY2  11  0.000000 -1.000000  0.000000       37.57309
REMARK 290   SMTRY3  11  0.000000  0.000000 -1.000000      102.06133
REMARK 290   SMTRY1  12 -0.500000 -0.866025  0.000000       65.07850
REMARK 290   SMTRY2  12 -0.866025  0.500000  0.000000       37.57309
REMARK 290   SMTRY3  12  0.000000  0.000000 -1.000000      102.06133
REMARK 290   SMTRY1  13  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2  13  0.000000  1.000000  0.000000       75.14618
REMARK 290   SMTRY3  13  0.000000  0.000000  1.000000      204.12267
REMARK 290   SMTRY1  14 -0.500000 -0.866025  0.000000        0.00000
REMARK 290   SMTRY2  14  0.866025 -0.500000  0.000000       75.14618
REMARK 290   SMTRY3  14  0.000000  0.000000  1.000000      204.12267
REMARK 290   SMTRY1  15 -0.500000  0.866025  0.000000        0.00000
REMARK 290   SMTRY2  15 -0.866025 -0.500000  0.000000       75.14618
REMARK 290   SMTRY3  15  0.000000  0.000000  1.000000      204.12267
REMARK 290   SMTRY1  16 -0.500000  0.866025  0.000000        0.00000
REMARK 290   SMTRY2  16  0.866025  0.500000  0.000000       75.14618
REMARK 290   SMTRY3  16  0.000000  0.000000 -1.000000      204.12267
REMARK 290   SMTRY1  17  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2  17  0.000000 -1.000000  0.000000       75.14618
REMARK 290   SMTRY3  17  0.000000  0.000000 -1.000000      204.12267
REMARK 290   SMTRY1  18 -0.500000 -0.866025  0.000000        0.00000
REMARK 290   SMTRY2  18 -0.866025  0.500000  0.000000       75.14618
REMARK 290   SMTRY3  18  0.000000  0.000000 -1.000000      204.12267
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350   BIOMT1   2 -0.500000 -0.866025  0.000000        0.00000
REMARK 350   BIOMT2   2  0.866025 -0.500000  0.000000        0.00000
REMARK 350   BIOMT3   2  0.000000  0.000000  1.000000        0.00000
REMARK 350   BIOMT1   3 -0.500000  0.866025  0.000000        0.00000
REMARK 350   BIOMT2   3 -0.866025 -0.500000  0.000000        0.00000
REMARK 350   BIOMT3   3  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 3
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     GLN A    16
REMARK 465     GLU A    17
REMARK 465     ASP A    18
REMARK 465     VAL A    19
REMARK 465     THR A    20
REMARK 465     GLN B    16
REMARK 465     GLU B    17
REMARK 465     ASP B    18
REMARK 465     VAL B    19
REMARK 465     THR B    20
REMARK 465     ARG B   249
REMARK 465     GLU B   250
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS(M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     ARG A 395    O
REMARK 470     ARG B 395    O
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    THR A  64      102.89   -177.02
REMARK 500    HIS A 106       59.91    -91.81
REMARK 500    MET A 121      106.56      1.46
REMARK 500    ASP A 150      137.53   -179.33
REMARK 500    ILE A 155      -34.26    108.59
REMARK 500    VAL A 171      127.35    -28.25
REMARK 500    TYR A 206      -52.26   -125.61
REMARK 500    CYS A 229      117.79    173.06
REMARK 500    SER A 240     -146.05   -137.97
REMARK 500    SER A 241      155.79    166.08
REMARK 500    THR A 244       57.76    -63.44
REMARK 500    ASP A 248      127.72    165.72
REMARK 500    ARG A 249       70.61   -102.31
REMARK 500    GLU A 250      -61.90   -145.58
REMARK 500    PRO A 252       49.11    -76.27
REMARK 500    ARG A 279       54.21   -141.63
REMARK 500    SER A 286     -112.19     68.19
REMARK 500    PHE A 299       57.09   -143.18
REMARK 500    CYS A 310       78.96     35.55
REMARK 500    ASP B  66      -25.92    172.39
REMARK 500    TYR B  77     -163.50   -179.71
REMARK 500    ASN B  79      167.60    179.16
REMARK 500    SER B  81      -86.56   -112.46
REMARK 500    LEU B  84       34.39    -94.40
REMARK 500    PRO B 114       49.62    -86.09
REMARK 500    ASN B 115     -138.97   -140.06
REMARK 500    PHE B 116       56.17   -109.49
REMARK 500    ILE B 155        7.05     55.98
REMARK 500    GLU B 168      -67.65    -23.97
REMARK 500    THR B 169      141.81    157.95
REMARK 500    ASN B 184      126.41    -35.20
REMARK 500    ASP B 186       42.02   -100.21
REMARK 500    THR B 203       -6.77   -145.38
REMARK 500    TYR B 206      -53.53   -132.44
REMARK 500    PRO B 238      150.72    -48.42
REMARK 500    ASN B 239       -9.17     67.39
REMARK 500    THR B 244       41.66    -71.90
REMARK 500    SER B 286     -106.93     58.23
REMARK 500    HIS B 330      139.93   -170.32
REMARK 500    LYS B 355       47.16     76.36
REMARK 500    PRO B 373        6.07    -65.96
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500                                 MODEL     OMEGA
REMARK 500 ARG A  120     MET A  121                  138.10
REMARK 500 MET A  121     LYS A  122                  143.06
REMARK 500 ASP A  137     GLY A  138                  -43.22
REMARK 500 PRO A  228     CYS A  229                 -114.19
REMARK 500 CYS A  236     PRO A  237                 -148.52
REMARK 500 PRO A  237     PRO A  238                 -132.23
REMARK 500 GLY A  312     GLY A  313                 -125.58
REMARK 500 GLY A  353     GLY A  354                  129.79
REMARK 500 THR B   64     GLY B   65                  -53.00
REMARK 500 TYR B   77     ALA B   78                 -149.74
REMARK 500 GLY B   82     GLY B   83                  142.32
REMARK 500 GLY B  113     PRO B  114                 -142.30
REMARK 500 LYS B  181     ASP B  182                  -65.53
REMARK 500 ASP B  182     VAL B  183                 -147.75
REMARK 500 HIS B  196     GLY B  197                   77.75
REMARK 500 GLY B  353     GLY B  354                  135.17
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CHIRAL CENTERS
REMARK 500
REMARK 500 UNEXPECTED CONFIGURATION OF THE FOLLOWING CHIRAL
REMARK 500 CENTER(S) USING IMPROPER CA--C--CB--N CHIRALITY
REMARK 500 M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (11X,I3,1X,A3,1X,A1,I4,A1,6X,F5.1,6X,A1,10X,A1,3X,A16)
REMARK 500
REMARK 500   M RES CSSEQI    IMPROPER   EXPECTED   FOUND DETAILS
REMARK 500     ASN B  90        21.9      L          L   OUTSIDE RANGE
REMARK 500
REMARK 500 REMARK: NULL
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A 400
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A 401
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A 402
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A 403
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A 404
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 B 500
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 B 501
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A 502
REMARK 800 SITE_IDENTIFIER: AC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 B 503
REMARK 800 SITE_IDENTIFIER: BC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 B 504
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 3DOI   RELATED DB: PDB
DBREF  3DOH A   16   395  UNP    Q9WXP0   Q9WXP0_THEMA    16    395
DBREF  3DOH B   16   395  UNP    Q9WXP0   Q9WXP0_THEMA    16    395
SEQRES   1 A  380  GLN GLU ASP VAL THR VAL LYS SER VAL THR LEU ILE THR
SEQRES   2 A  380  LYS VAL PHE PRO GLU GLY GLU LYS VAL CYS ALA VAL VAL
SEQRES   3 A  380  ILE GLU TYR PRO VAL GLU ILE ASP GLY GLN LYS LEU SER
SEQRES   4 A  380  PRO ASP GLN PHE SER VAL LYS VAL LYS THR GLY ASP THR
SEQRES   5 A  380  TYR SER SER ARG THR ILE THR LYS VAL TYR ALA ASN ASN
SEQRES   6 A  380  SER GLY GLY LEU SER PHE SER ILE PHE ASN ASN ARG GLY
SEQRES   7 A  380  LYS TYR VAL VAL LEU GLU LEU SER THR GLU ASP LEU HIS
SEQRES   8 A  380  SER ASN THR ILE VAL PHE GLY PRO ASN PHE LEU ASN THR
SEQRES   9 A  380  ARG MET LYS LEU ASP TYR ILE VAL SER GLN LEU VAL PRO
SEQRES  10 A  380  ILE PHE ASP VAL ASP GLY ASN GLU VAL GLU PRO PHE THR
SEQRES  11 A  380  SER LYS GLN THR ASP GLU LYS HIS LEU ILE ILE ASP ASP
SEQRES  12 A  380  PHE LEU ALA PHE THR PHE LYS ASP PRO GLU THR GLY VAL
SEQRES  13 A  380  GLU ILE PRO TYR ARG LEU PHE VAL PRO LYS ASP VAL ASN
SEQRES  14 A  380  PRO ASP ARG LYS TYR PRO LEU VAL VAL PHE LEU HIS GLY
SEQRES  15 A  380  ALA GLY GLU ARG GLY THR ASP ASN TYR LEU GLN VAL ALA
SEQRES  16 A  380  GLY ASN ARG GLY ALA VAL VAL TRP ALA GLN PRO ARG TYR
SEQRES  17 A  380  GLN VAL VAL HIS PRO CYS PHE VAL LEU ALA PRO GLN CYS
SEQRES  18 A  380  PRO PRO ASN SER SER TRP SER THR LEU PHE THR ASP ARG
SEQRES  19 A  380  GLU ASN PRO PHE ASN PRO GLU LYS PRO LEU LEU ALA VAL
SEQRES  20 A  380  ILE LYS ILE ILE ARG LYS LEU LEU ASP GLU TYR ASN ILE
SEQRES  21 A  380  ASP GLU ASN ARG ILE TYR ILE THR GLY LEU SER MET GLY
SEQRES  22 A  380  GLY TYR GLY THR TRP THR ALA ILE MET GLU PHE PRO GLU
SEQRES  23 A  380  LEU PHE ALA ALA ALA ILE PRO ILE CYS GLY GLY GLY ASP
SEQRES  24 A  380  VAL SER LYS VAL GLU ARG ILE LYS ASP ILE PRO ILE TRP
SEQRES  25 A  380  VAL PHE HIS ALA GLU ASP ASP PRO VAL VAL PRO VAL GLU
SEQRES  26 A  380  ASN SER ARG VAL LEU VAL LYS LYS LEU ALA GLU ILE GLY
SEQRES  27 A  380  GLY LYS VAL ARG TYR THR GLU TYR GLU LYS GLY PHE MET
SEQRES  28 A  380  GLU LYS HIS GLY TRP ASP PRO HIS GLY SER TRP ILE PRO
SEQRES  29 A  380  THR TYR GLU ASN GLN GLU ALA ILE GLU TRP LEU PHE GLU
SEQRES  30 A  380  GLN SER ARG
SEQRES   1 B  380  GLN GLU ASP VAL THR VAL LYS SER VAL THR LEU ILE THR
SEQRES   2 B  380  LYS VAL PHE PRO GLU GLY GLU LYS VAL CYS ALA VAL VAL
SEQRES   3 B  380  ILE GLU TYR PRO VAL GLU ILE ASP GLY GLN LYS LEU SER
SEQRES   4 B  380  PRO ASP GLN PHE SER VAL LYS VAL LYS THR GLY ASP THR
SEQRES   5 B  380  TYR SER SER ARG THR ILE THR LYS VAL TYR ALA ASN ASN
SEQRES   6 B  380  SER GLY GLY LEU SER PHE SER ILE PHE ASN ASN ARG GLY
SEQRES   7 B  380  LYS TYR VAL VAL LEU GLU LEU SER THR GLU ASP LEU HIS
SEQRES   8 B  380  SER ASN THR ILE VAL PHE GLY PRO ASN PHE LEU ASN THR
SEQRES   9 B  380  ARG MET LYS LEU ASP TYR ILE VAL SER GLN LEU VAL PRO
SEQRES  10 B  380  ILE PHE ASP VAL ASP GLY ASN GLU VAL GLU PRO PHE THR
SEQRES  11 B  380  SER LYS GLN THR ASP GLU LYS HIS LEU ILE ILE ASP ASP
SEQRES  12 B  380  PHE LEU ALA PHE THR PHE LYS ASP PRO GLU THR GLY VAL
SEQRES  13 B  380  GLU ILE PRO TYR ARG LEU PHE VAL PRO LYS ASP VAL ASN
SEQRES  14 B  380  PRO ASP ARG LYS TYR PRO LEU VAL VAL PHE LEU HIS GLY
SEQRES  15 B  380  ALA GLY GLU ARG GLY THR ASP ASN TYR LEU GLN VAL ALA
SEQRES  16 B  380  GLY ASN ARG GLY ALA VAL VAL TRP ALA GLN PRO ARG TYR
SEQRES  17 B  380  GLN VAL VAL HIS PRO CYS PHE VAL LEU ALA PRO GLN CYS
SEQRES  18 B  380  PRO PRO ASN SER SER TRP SER THR LEU PHE THR ASP ARG
SEQRES  19 B  380  GLU ASN PRO PHE ASN PRO GLU LYS PRO LEU LEU ALA VAL
SEQRES  20 B  380  ILE LYS ILE ILE ARG LYS LEU LEU ASP GLU TYR ASN ILE
SEQRES  21 B  380  ASP GLU ASN ARG ILE TYR ILE THR GLY LEU SER MET GLY
SEQRES  22 B  380  GLY TYR GLY THR TRP THR ALA ILE MET GLU PHE PRO GLU
SEQRES  23 B  380  LEU PHE ALA ALA ALA ILE PRO ILE CYS GLY GLY GLY ASP
SEQRES  24 B  380  VAL SER LYS VAL GLU ARG ILE LYS ASP ILE PRO ILE TRP
SEQRES  25 B  380  VAL PHE HIS ALA GLU ASP ASP PRO VAL VAL PRO VAL GLU
SEQRES  26 B  380  ASN SER ARG VAL LEU VAL LYS LYS LEU ALA GLU ILE GLY
SEQRES  27 B  380  GLY LYS VAL ARG TYR THR GLU TYR GLU LYS GLY PHE MET
SEQRES  28 B  380  GLU LYS HIS GLY TRP ASP PRO HIS GLY SER TRP ILE PRO
SEQRES  29 B  380  THR TYR GLU ASN GLN GLU ALA ILE GLU TRP LEU PHE GLU
SEQRES  30 B  380  GLN SER ARG
HET    SO4  A 400       5
HET    SO4  A 401       5
HET    SO4  A 402       5
HET    SO4  A 403       5
HET    SO4  A 404       5
HET    SO4  A 502       5
HET    SO4  B 500       5
HET    SO4  B 501       5
HET    SO4  B 503       5
HET    SO4  B 504       5
HETNAM     SO4 SULFATE ION
FORMUL   3  SO4    10(O4 S 2-)
FORMUL  13  HOH   *156(H2 O)
HELIX    1   1 GLN A   51  LEU A   53  5                                   3
HELIX    2   2 SER A   54  ASP A   56  5                                   3
HELIX    3   3 ASP A  104  ASN A  108  5                                   5
HELIX    4   4 ILE A  155  ASP A  157  5                                   3
HELIX    5   5 GLY A  197  ARG A  201  5                                   5
HELIX    6   6 TYR A  206  GLY A  211  1                                   6
HELIX    7   7 VAL A  216  ALA A  219  5                                   4
HELIX    8   8 GLN A  220  VAL A  225  1                                   6
HELIX    9   9 GLU A  256  TYR A  273  1                                  18
HELIX   10  10 SER A  286  PHE A  299  1                                  14
HELIX   11  11 ASP A  314  LYS A  322  5                                   9
HELIX   12  12 VAL A  339  ILE A  352  1                                  14
HELIX   13  13 GLY A  364  HIS A  369  1                                   6
HELIX   14  14 SER A  376  GLU A  382  1                                   7
HELIX   15  15 ASN A  383  GLU A  392  1                                  10
HELIX   16  16 ASP B   49  LEU B   53  5                                   5
HELIX   17  17 SER B   54  ASP B   56  5                                   3
HELIX   18  18 ASP B  104  ASN B  108  5                                   5
HELIX   19  19 TYR B  206  GLY B  211  1                                   6
HELIX   20  20 VAL B  216  ALA B  219  5                                   4
HELIX   21  21 GLN B  220  VAL B  225  1                                   6
HELIX   22  22 GLU B  256  TYR B  273  1                                  18
HELIX   23  23 SER B  286  PHE B  299  1                                  14
HELIX   24  24 ASP B  314  LYS B  322  5                                   9
HELIX   25  25 VAL B  339  ILE B  352  1                                  14
HELIX   26  26 GLY B  364  HIS B  369  1                                   6
HELIX   27  27 SER B  376  GLU B  382  1                                   7
HELIX   28  28 ASN B  383  GLU B  392  1                                  10
SHEET    1   A 5 ILE A  73  ASN A  79  0
SHEET    2   A 5 ARG A  92  LEU A 100 -1  O  VAL A  97   N  TYR A  77
SHEET    3   A 5 GLY A  34  ASP A  49 -1  N  ILE A  42   O  VAL A  96
SHEET    4   A 5 SER A  23  PHE A  31 -1  N  ILE A  27   O  ALA A  39
SHEET    5   A 5 ASP A 150  LEU A 154  1  O  ASP A 150   N  LEU A  26
SHEET    1   B 4 TYR A  68  ARG A  71  0
SHEET    2   B 4 PHE A  58  LYS A  63 -1  N  VAL A  60   O  ARG A  71
SHEET    3   B 4 TYR A 125  GLN A 129 -1  O  SER A 128   N  SER A  59
SHEET    4   B 4 PHE A 144  LYS A 147 -1  O  SER A 146   N  VAL A 127
SHEET    1   C 6 PHE A 159  LYS A 165  0
SHEET    2   C 6 GLU A 172  PHE A 178 -1  O  TYR A 175   N  PHE A 162
SHEET    3   C 6 PHE A 230  PRO A 234 -1  O  ALA A 233   N  ARG A 176
SHEET    4   C 6 TYR A 189  LEU A 195  1  N  VAL A 192   O  PHE A 230
SHEET    5   C 6 ILE A 275  LEU A 285  1  O  TYR A 281   N  LEU A 191
SHEET    6   C 6 ALA A 305  ILE A 309  1  O  ILE A 309   N  GLY A 284
SHEET    1   D 2 ILE A 326  ALA A 331  0
SHEET    2   D 2 VAL A 356  TYR A 361  1  O  ARG A 357   N  ILE A 326
SHEET    1   E 5 ILE B  73  ASN B  79  0
SHEET    2   E 5 TYR B  95  LEU B 100 -1  O  VAL B  97   N  TYR B  77
SHEET    3   E 5 GLY B  34  GLU B  43 -1  N  VAL B  40   O  LEU B  98
SHEET    4   E 5 SER B  23  PHE B  31 -1  N  PHE B  31   O  GLY B  34
SHEET    5   E 5 ASP B 150  HIS B 153  1  O  ASP B 150   N  LEU B  26
SHEET    1   F 4 THR B  67  ARG B  71  0
SHEET    2   F 4 PHE B  58  THR B  64 -1  N  THR B  64   O  THR B  67
SHEET    3   F 4 TYR B 125  GLN B 129 -1  O  ILE B 126   N  LYS B  61
SHEET    4   F 4 PHE B 144  LYS B 147 -1  O  SER B 146   N  VAL B 127
SHEET    1   G 2 ILE B 110  VAL B 111  0
SHEET    2   G 2 THR B 119  ARG B 120 -1  O  THR B 119   N  VAL B 111
SHEET    1   H 2 ILE B 133  PHE B 134  0
SHEET    2   H 2 GLU B 140  VAL B 141 -1  O  VAL B 141   N  ILE B 133
SHEET    1   I 6 LEU B 160  LYS B 165  0
SHEET    2   I 6 GLU B 172  PHE B 178 -1  O  ILE B 173   N  PHE B 164
SHEET    3   I 6 PHE B 230  PRO B 234 -1  O  ALA B 233   N  ARG B 176
SHEET    4   I 6 TYR B 189  LEU B 195  1  N  VAL B 192   O  PHE B 230
SHEET    5   I 6 ILE B 275  LEU B 285  1  O  TYR B 281   N  LEU B 191
SHEET    6   I 6 ALA B 305  ILE B 309  1  O  ILE B 309   N  GLY B 284
SHEET    1   J 2 ILE B 326  ALA B 331  0
SHEET    2   J 2 VAL B 356  TYR B 361  1  O  ARG B 357   N  ILE B 326
CISPEP   1 THR A   64    GLY A   65          0         3.01
CISPEP   2 PRO A  114    ASN A  115          0       -22.00
CISPEP   3 GLY A  138    ASN A  139          0       -22.59
CISPEP   4 ARG B   92    GLY B   93          0        -7.68
CISPEP   5 PRO B  167    GLU B  168          0        14.03
CISPEP   6 THR B  169    GLY B  170          0         5.83
SITE     1 AC1  7 PHE A 116  GLY A 197  ALA A 198  GLY A 199
SITE     2 AC1  7 SER A 286  MET A 287  HIS A 374
SITE     1 AC2  5 LYS A  29  ARG A 222  GLU A 332  GLU A 362
SITE     2 AC2  5 LYS A 363
SITE     1 AC3  4 LYS A  61  SER A  69  SER A  70  ASP B  56
SITE     1 AC4  5 LYS A 152  LEU A 154  ILE A 155  ASP A 157
SITE     2 AC4  5 ASP A 158
SITE     1 AC5  4 HIS A 153  ASP A 157  ARG A 176  TYR A 206
SITE     1 AC6  7 PHE B 116  GLY B 197  ALA B 198  GLY B 199
SITE     2 AC6  7 SER B 286  MET B 287  HIS B 374
SITE     1 AC7  5 LYS B  29  ARG B 222  GLU B 332  GLU B 362
SITE     2 AC7  5 LYS B 363
SITE     1 AC8  3 ASP A  56  SER B  69  SER B  70
SITE     1 AC9  5 LYS B 152  LEU B 154  ILE B 155  ASP B 157
SITE     2 AC9  5 ASP B 158
SITE     1 BC1  4 HIS B 153  ILE B 156  ASP B 157  ARG B 176
CRYST1  130.157  130.157  306.184  90.00  90.00 120.00 H 3 2        36
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.007683  0.004436  0.000000        0.00000
SCALE2      0.000000  0.008872  0.000000        0.00000
SCALE3      0.000000  0.000000  0.003266        0.00000
TER    3002      ARG A 395
TER    5984      ARG B 395
MASTER      470    0   10   28   38    0   16    6 6188    2   50   60
END