longtext: 3PUH-pdb

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HEADER    HYDROLASE                               04-DEC-10   3PUH
TITLE     COCAINE ESTERASE, WILD-TYPE BIOLOGICALLY ACTIVE DIMER
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: COCAINE ESTERASE;
COMPND   3 CHAIN: A, B;
COMPND   4 EC: 3.1.1.-;
COMPND   5 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: RHODOCOCCUS SP.;
SOURCE   3 ORGANISM_TAXID: 104109;
SOURCE   4 STRAIN: MB1 BRESLER;
SOURCE   5 GENE: COCE;
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: BL21 GOLD DE3;
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PET-22B (+)
KEYWDS    ALPHA/BETA HYDROLASE, JELLY-ROLL BETA-BARREL, CLEAVAGE OF COCAINE,
KEYWDS   2 HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    M.R.NANCE,J.J.G.TESMER
REVDAT   1   21-SEP-11 3PUH    0
JRNL        AUTH   D.NARASIMHAN,G.T.COLLINS,M.R.NANCE,J.NICHOLS,E.EDWALD,
JRNL        AUTH 2 J.CHAN,M.C.KO,J.H.WOODS,J.J.TESMER,R.K.SUNAHARA
JRNL        TITL   SUBUNIT STABILIZATION AND PEGYLATION OF COCAINE ESTERASE
JRNL        TITL 2 IMPROVES IN VIVO RESIDENCE TIME.
JRNL        REF    MOL.PHARMACOL.                             2011
JRNL        REFN                   ESSN 1521-0111
JRNL        PMID   21890748
JRNL        DOI    10.1124/MOL.111.074997
REMARK   2
REMARK   2 RESOLUTION.    2.30 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.5.0102
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.30
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 25.00
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.8
REMARK   3   NUMBER OF REFLECTIONS             : 78375
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.210
REMARK   3   R VALUE            (WORKING SET) : 0.208
REMARK   3   FREE R VALUE                     : 0.249
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000
REMARK   3   FREE R VALUE TEST SET COUNT      : 3947
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.30
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.35
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 5221
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 97.78
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2500
REMARK   3   BIN FREE R VALUE SET COUNT          : 320
REMARK   3   BIN FREE R VALUE                    : 0.3170
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 8741
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 38
REMARK   3   SOLVENT ATOMS            : 778
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 23.00
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : 0.80000
REMARK   3    B22 (A**2) : 0.17000
REMARK   3    B33 (A**2) : -0.98000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): NULL
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.210
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.146
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 5.957
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.934
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.908
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  9076 ; 0.014 ; 0.022
REMARK   3   BOND LENGTHS OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 12423 ; 1.384 ; 1.953
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  1163 ; 5.151 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   405 ;33.470 ;23.728
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  1335 ;13.318 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    65 ;14.546 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  1391 ; 0.087 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  7071 ; 0.005 ; 0.021
REMARK   3   GENERAL PLANES OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  5749 ; 0.302 ; 1.500
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  9286 ; 0.565 ; 2.000
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  3327 ; 0.715 ; 3.000
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  3137 ; 1.238 ; 4.500
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : 1
REMARK   3
REMARK   3  NCS GROUP NUMBER               : 1
REMARK   3     CHAIN NAMES                    : A B
REMARK   3     NUMBER OF COMPONENTS NCS GROUP : 1
REMARK   3       COMPONENT C  SSSEQI  TO  C   SSSEQI   CODE
REMARK   3           1     A      1       A     600      4
REMARK   3           1     B      1       B     600      4
REMARK   3                   GROUP CHAIN        COUNT   RMS     WEIGHT
REMARK   3   MEDIUM POSITIONAL  1    A    (A):   4305 ; 0.200 ; 0.500
REMARK   3   MEDIUM THERMAL     1    A (A**2):   4305 ; 0.240 ; 2.000
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.40
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING
REMARK   3  POSITIONS U VALUES: REFINED INDIVIDUALLY
REMARK   4
REMARK   4 3PUH COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 07-DEC-10.
REMARK 100 THE RCSB ID CODE IS RCSB062826.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 16-FEB-08
REMARK 200  TEMPERATURE           (KELVIN) : NULL
REMARK 200  PH                             : 6.0
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : APS
REMARK 200  BEAMLINE                       : 21-ID-D
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.033
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : MAR SCANNER 300 MM PLATE
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL
REMARK 200  DATA SCALING SOFTWARE          : HKL
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 78491
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.300
REMARK 200  RESOLUTION RANGE LOW       (A) : 25.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 100.0
REMARK 200  DATA REDUNDANCY                : 7.900
REMARK 200  R MERGE                    (I) : 0.13400
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 6.7000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.30
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.38
REMARK 200  COMPLETENESS FOR SHELL     (%) : 100.0
REMARK 200  DATA REDUNDANCY IN SHELL       : 6.40
REMARK 200  R MERGE FOR SHELL          (I) : 0.61000
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 63.89
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.41
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 20% PEG 3350, 100 MM MES PH 6.0, 1 M
REMARK 280  NACL, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X+1/2,-Y,Z+1/2
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       36.67250
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000      112.25900
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       52.72100
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000      112.25900
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       36.67250
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       52.72100
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 300 REMARK: THE BIOLOGICAL ASSEMBLY IS A HOMODIMER OF COCE, CONSISTING
REMARK 300 OF CHAIN A AND CHAIN B.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 3850 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 46180 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -42.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A     1
REMARK 465     VAL A     2
REMARK 465     ASP A     3
REMARK 465     LYS A   575
REMARK 465     LEU A   576
REMARK 465     ALA A   577
REMARK 465     ALA A   578
REMARK 465     ALA A   579
REMARK 465     LEU A   580
REMARK 465     GLU A   581
REMARK 465     HIS A   582
REMARK 465     HIS A   583
REMARK 465     HIS A   584
REMARK 465     HIS A   585
REMARK 465     HIS A   586
REMARK 465     HIS A   587
REMARK 465     LYS B   575
REMARK 465     LEU B   576
REMARK 465     ALA B   577
REMARK 465     ALA B   578
REMARK 465     ALA B   579
REMARK 465     LEU B   580
REMARK 465     GLU B   581
REMARK 465     HIS B   582
REMARK 465     HIS B   583
REMARK 465     HIS B   584
REMARK 465     HIS B   585
REMARK 465     HIS B   586
REMARK 465     HIS B   587
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ASP A  45      110.30     80.23
REMARK 500    SER A  56      -87.36   -133.81
REMARK 500    PHE A  78     -108.07     52.25
REMARK 500    HIS A  87      -39.63     76.80
REMARK 500    SER A 117     -114.60     64.71
REMARK 500    TYR A 152     -120.36   -121.27
REMARK 500    ASP A 198       86.31   -154.06
REMARK 500    ASP A 232     -156.15    -97.04
REMARK 500    PRO A 284       45.02    -95.29
REMARK 500    THR A 371      160.38     72.59
REMARK 500    ASN A 413       59.71   -145.25
REMARK 500    HIS A 422       30.02    -91.63
REMARK 500    LEU A 476      -70.03   -116.75
REMARK 500    LEU A 508     -119.94     57.06
REMARK 500    SER A 525     -159.88   -158.80
REMARK 500    ASN A 528       83.50   -167.33
REMARK 500    ASP B  45      111.89     76.57
REMARK 500    SER B  56      -91.80   -133.61
REMARK 500    PHE B  78     -106.65     52.39
REMARK 500    HIS B  87      -39.91     73.58
REMARK 500    SER B 117     -116.18     68.57
REMARK 500    ALA B 138       78.63   -151.29
REMARK 500    TYR B 152     -120.25   -120.61
REMARK 500    ASP B 198       76.22   -155.67
REMARK 500    ASP B 232     -151.28    -94.25
REMARK 500    ALA B 248       48.32   -147.36
REMARK 500    PRO B 284       46.98    -94.98
REMARK 500    ASP B 355       42.05   -103.55
REMARK 500    THR B 371      169.56     67.70
REMARK 500    ASN B 410       58.69     38.93
REMARK 500    ASN B 413       58.62   -145.91
REMARK 500    LEU B 476      -62.88   -120.36
REMARK 500    LEU B 508     -118.07     62.61
REMARK 500    SER B 525     -157.46   -156.36
REMARK 500    ASN B 528       85.44   -168.44
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CHIRAL CENTERS
REMARK 500
REMARK 500 UNEXPECTED CONFIGURATION OF THE FOLLOWING CHIRAL
REMARK 500 CENTER(S) USING IMPROPER CA--C--CB--N CHIRALITY
REMARK 500 FOR AMINO ACIDS AND C1'--O4'--N1(N9)--C2' FOR
REMARK 500 NUCLEIC ACIDS OR EQUIVALENT ANGLE
REMARK 500 M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,6X,F5.1,6X,A1,10X,A1,3X,A16)
REMARK 500
REMARK 500  M RES CSSEQI    IMPROPER   EXPECTED   FOUND DETAILS
REMARK 500    HIS A 422        24.7      L          L   OUTSIDE RANGE
REMARK 500
REMARK 500 REMARK: NULL
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL A 588
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL A 589
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A 590
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A 591
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A 592
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 588
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 B 589
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 3I2F   RELATED DB: PDB
REMARK 900 RELATED ID: 3I2G   RELATED DB: PDB
REMARK 900 RELATED ID: 3I2H   RELATED DB: PDB
REMARK 900 RELATED ID: 3I2I   RELATED DB: PDB
REMARK 900 RELATED ID: 3I2J   RELATED DB: PDB
REMARK 900 RELATED ID: 1JU3   RELATED DB: PDB
REMARK 900 RELATED ID: 3IDA   RELATED DB: PDB
REMARK 900 RELATED ID: 1JU4   RELATED DB: PDB
REMARK 900 RELATED ID: 3PUI   RELATED DB: PDB
DBREF  3PUH A    1   574  UNP    Q9L9D7   COCE_RHOSM       1    574
DBREF  3PUH B    1   574  UNP    Q9L9D7   COCE_RHOSM       1    574
SEQADV 3PUH LYS A  575  UNP  Q9L9D7              EXPRESSION TAG
SEQADV 3PUH LEU A  576  UNP  Q9L9D7              EXPRESSION TAG
SEQADV 3PUH ALA A  577  UNP  Q9L9D7              EXPRESSION TAG
SEQADV 3PUH ALA A  578  UNP  Q9L9D7              EXPRESSION TAG
SEQADV 3PUH ALA A  579  UNP  Q9L9D7              EXPRESSION TAG
SEQADV 3PUH LEU A  580  UNP  Q9L9D7              EXPRESSION TAG
SEQADV 3PUH GLU A  581  UNP  Q9L9D7              EXPRESSION TAG
SEQADV 3PUH HIS A  582  UNP  Q9L9D7              EXPRESSION TAG
SEQADV 3PUH HIS A  583  UNP  Q9L9D7              EXPRESSION TAG
SEQADV 3PUH HIS A  584  UNP  Q9L9D7              EXPRESSION TAG
SEQADV 3PUH HIS A  585  UNP  Q9L9D7              EXPRESSION TAG
SEQADV 3PUH HIS A  586  UNP  Q9L9D7              EXPRESSION TAG
SEQADV 3PUH HIS A  587  UNP  Q9L9D7              EXPRESSION TAG
SEQADV 3PUH LYS B  575  UNP  Q9L9D7              EXPRESSION TAG
SEQADV 3PUH LEU B  576  UNP  Q9L9D7              EXPRESSION TAG
SEQADV 3PUH ALA B  577  UNP  Q9L9D7              EXPRESSION TAG
SEQADV 3PUH ALA B  578  UNP  Q9L9D7              EXPRESSION TAG
SEQADV 3PUH ALA B  579  UNP  Q9L9D7              EXPRESSION TAG
SEQADV 3PUH LEU B  580  UNP  Q9L9D7              EXPRESSION TAG
SEQADV 3PUH GLU B  581  UNP  Q9L9D7              EXPRESSION TAG
SEQADV 3PUH HIS B  582  UNP  Q9L9D7              EXPRESSION TAG
SEQADV 3PUH HIS B  583  UNP  Q9L9D7              EXPRESSION TAG
SEQADV 3PUH HIS B  584  UNP  Q9L9D7              EXPRESSION TAG
SEQADV 3PUH HIS B  585  UNP  Q9L9D7              EXPRESSION TAG
SEQADV 3PUH HIS B  586  UNP  Q9L9D7              EXPRESSION TAG
SEQADV 3PUH HIS B  587  UNP  Q9L9D7              EXPRESSION TAG
SEQRES   1 A  587  MET VAL ASP GLY ASN TYR SER VAL ALA SER ASN VAL MET
SEQRES   2 A  587  VAL PRO MET ARG ASP GLY VAL ARG LEU ALA VAL ASP LEU
SEQRES   3 A  587  TYR ARG PRO ASP ALA ASP GLY PRO VAL PRO VAL LEU LEU
SEQRES   4 A  587  VAL ARG ASN PRO TYR ASP LYS PHE ASP VAL PHE ALA TRP
SEQRES   5 A  587  SER THR GLN SER THR ASN TRP LEU GLU PHE VAL ARG ASP
SEQRES   6 A  587  GLY TYR ALA VAL VAL ILE GLN ASP THR ARG GLY LEU PHE
SEQRES   7 A  587  ALA SER GLU GLY GLU PHE VAL PRO HIS VAL ASP ASP GLU
SEQRES   8 A  587  ALA ASP ALA GLU ASP THR LEU SER TRP ILE LEU GLU GLN
SEQRES   9 A  587  ALA TRP CYS ASP GLY ASN VAL GLY MET PHE GLY VAL SER
SEQRES  10 A  587  TYR LEU GLY VAL THR GLN TRP GLN ALA ALA VAL SER GLY
SEQRES  11 A  587  VAL GLY GLY LEU LYS ALA ILE ALA PRO SER MET ALA SER
SEQRES  12 A  587  ALA ASP LEU TYR ARG ALA PRO TRP TYR GLY PRO GLY GLY
SEQRES  13 A  587  ALA LEU SER VAL GLU ALA LEU LEU GLY TRP SER ALA LEU
SEQRES  14 A  587  ILE GLY THR GLY LEU ILE THR SER ARG SER ASP ALA ARG
SEQRES  15 A  587  PRO GLU ASP ALA ALA ASP PHE VAL GLN LEU ALA ALA ILE
SEQRES  16 A  587  LEU ASN ASP VAL ALA GLY ALA ALA SER VAL THR PRO LEU
SEQRES  17 A  587  ALA GLU GLN PRO LEU LEU GLY ARG LEU ILE PRO TRP VAL
SEQRES  18 A  587  ILE ASP GLN VAL VAL ASP HIS PRO ASP ASN ASP GLU SER
SEQRES  19 A  587  TRP GLN SER ILE SER LEU PHE GLU ARG LEU GLY GLY LEU
SEQRES  20 A  587  ALA THR PRO ALA LEU ILE THR ALA GLY TRP TYR ASP GLY
SEQRES  21 A  587  PHE VAL GLY GLU SER LEU ARG THR PHE VAL ALA VAL LYS
SEQRES  22 A  587  ASP ASN ALA ASP ALA ARG LEU VAL VAL GLY PRO TRP SER
SEQRES  23 A  587  HIS SER ASN LEU THR GLY ARG ASN ALA ASP ARG LYS PHE
SEQRES  24 A  587  GLY ILE ALA ALA THR TYR PRO ILE GLN GLU ALA THR THR
SEQRES  25 A  587  MET HIS LYS ALA PHE PHE ASP ARG HIS LEU ARG GLY GLU
SEQRES  26 A  587  THR ASP ALA LEU ALA GLY VAL PRO LYS VAL ARG LEU PHE
SEQRES  27 A  587  VAL MET GLY ILE ASP GLU TRP ARG ASP GLU THR ASP TRP
SEQRES  28 A  587  PRO LEU PRO ASP THR ALA TYR THR PRO PHE TYR LEU GLY
SEQRES  29 A  587  GLY SER GLY ALA ALA ASN THR SER THR GLY GLY GLY THR
SEQRES  30 A  587  LEU SER THR SER ILE SER GLY THR GLU SER ALA ASP THR
SEQRES  31 A  587  TYR LEU TYR ASP PRO ALA ASP PRO VAL PRO SER LEU GLY
SEQRES  32 A  587  GLY THR LEU LEU PHE HIS ASN GLY ASP ASN GLY PRO ALA
SEQRES  33 A  587  ASP GLN ARG PRO ILE HIS ASP ARG ASP ASP VAL LEU CYS
SEQRES  34 A  587  TYR SER THR GLU VAL LEU THR ASP PRO VAL GLU VAL THR
SEQRES  35 A  587  GLY THR VAL SER ALA ARG LEU PHE VAL SER SER SER ALA
SEQRES  36 A  587  VAL ASP THR ASP PHE THR ALA LYS LEU VAL ASP VAL PHE
SEQRES  37 A  587  PRO ASP GLY ARG ALA ILE ALA LEU CYS ASP GLY ILE VAL
SEQRES  38 A  587  ARG MET ARG TYR ARG GLU THR LEU VAL ASN PRO THR LEU
SEQRES  39 A  587  ILE GLU ALA GLY GLU ILE TYR GLU VAL ALA ILE ASP MET
SEQRES  40 A  587  LEU ALA THR SER ASN VAL PHE LEU PRO GLY HIS ARG ILE
SEQRES  41 A  587  MET VAL GLN VAL SER SER SER ASN PHE PRO LYS TYR ASP
SEQRES  42 A  587  ARG ASN SER ASN THR GLY GLY VAL ILE ALA ARG GLU GLN
SEQRES  43 A  587  LEU GLU GLU MET CYS THR ALA VAL ASN ARG ILE HIS ARG
SEQRES  44 A  587  GLY PRO GLU HIS PRO SER HIS ILE VAL LEU PRO ILE ILE
SEQRES  45 A  587  LYS ARG LYS LEU ALA ALA ALA LEU GLU HIS HIS HIS HIS
SEQRES  46 A  587  HIS HIS
SEQRES   1 B  587  MET VAL ASP GLY ASN TYR SER VAL ALA SER ASN VAL MET
SEQRES   2 B  587  VAL PRO MET ARG ASP GLY VAL ARG LEU ALA VAL ASP LEU
SEQRES   3 B  587  TYR ARG PRO ASP ALA ASP GLY PRO VAL PRO VAL LEU LEU
SEQRES   4 B  587  VAL ARG ASN PRO TYR ASP LYS PHE ASP VAL PHE ALA TRP
SEQRES   5 B  587  SER THR GLN SER THR ASN TRP LEU GLU PHE VAL ARG ASP
SEQRES   6 B  587  GLY TYR ALA VAL VAL ILE GLN ASP THR ARG GLY LEU PHE
SEQRES   7 B  587  ALA SER GLU GLY GLU PHE VAL PRO HIS VAL ASP ASP GLU
SEQRES   8 B  587  ALA ASP ALA GLU ASP THR LEU SER TRP ILE LEU GLU GLN
SEQRES   9 B  587  ALA TRP CYS ASP GLY ASN VAL GLY MET PHE GLY VAL SER
SEQRES  10 B  587  TYR LEU GLY VAL THR GLN TRP GLN ALA ALA VAL SER GLY
SEQRES  11 B  587  VAL GLY GLY LEU LYS ALA ILE ALA PRO SER MET ALA SER
SEQRES  12 B  587  ALA ASP LEU TYR ARG ALA PRO TRP TYR GLY PRO GLY GLY
SEQRES  13 B  587  ALA LEU SER VAL GLU ALA LEU LEU GLY TRP SER ALA LEU
SEQRES  14 B  587  ILE GLY THR GLY LEU ILE THR SER ARG SER ASP ALA ARG
SEQRES  15 B  587  PRO GLU ASP ALA ALA ASP PHE VAL GLN LEU ALA ALA ILE
SEQRES  16 B  587  LEU ASN ASP VAL ALA GLY ALA ALA SER VAL THR PRO LEU
SEQRES  17 B  587  ALA GLU GLN PRO LEU LEU GLY ARG LEU ILE PRO TRP VAL
SEQRES  18 B  587  ILE ASP GLN VAL VAL ASP HIS PRO ASP ASN ASP GLU SER
SEQRES  19 B  587  TRP GLN SER ILE SER LEU PHE GLU ARG LEU GLY GLY LEU
SEQRES  20 B  587  ALA THR PRO ALA LEU ILE THR ALA GLY TRP TYR ASP GLY
SEQRES  21 B  587  PHE VAL GLY GLU SER LEU ARG THR PHE VAL ALA VAL LYS
SEQRES  22 B  587  ASP ASN ALA ASP ALA ARG LEU VAL VAL GLY PRO TRP SER
SEQRES  23 B  587  HIS SER ASN LEU THR GLY ARG ASN ALA ASP ARG LYS PHE
SEQRES  24 B  587  GLY ILE ALA ALA THR TYR PRO ILE GLN GLU ALA THR THR
SEQRES  25 B  587  MET HIS LYS ALA PHE PHE ASP ARG HIS LEU ARG GLY GLU
SEQRES  26 B  587  THR ASP ALA LEU ALA GLY VAL PRO LYS VAL ARG LEU PHE
SEQRES  27 B  587  VAL MET GLY ILE ASP GLU TRP ARG ASP GLU THR ASP TRP
SEQRES  28 B  587  PRO LEU PRO ASP THR ALA TYR THR PRO PHE TYR LEU GLY
SEQRES  29 B  587  GLY SER GLY ALA ALA ASN THR SER THR GLY GLY GLY THR
SEQRES  30 B  587  LEU SER THR SER ILE SER GLY THR GLU SER ALA ASP THR
SEQRES  31 B  587  TYR LEU TYR ASP PRO ALA ASP PRO VAL PRO SER LEU GLY
SEQRES  32 B  587  GLY THR LEU LEU PHE HIS ASN GLY ASP ASN GLY PRO ALA
SEQRES  33 B  587  ASP GLN ARG PRO ILE HIS ASP ARG ASP ASP VAL LEU CYS
SEQRES  34 B  587  TYR SER THR GLU VAL LEU THR ASP PRO VAL GLU VAL THR
SEQRES  35 B  587  GLY THR VAL SER ALA ARG LEU PHE VAL SER SER SER ALA
SEQRES  36 B  587  VAL ASP THR ASP PHE THR ALA LYS LEU VAL ASP VAL PHE
SEQRES  37 B  587  PRO ASP GLY ARG ALA ILE ALA LEU CYS ASP GLY ILE VAL
SEQRES  38 B  587  ARG MET ARG TYR ARG GLU THR LEU VAL ASN PRO THR LEU
SEQRES  39 B  587  ILE GLU ALA GLY GLU ILE TYR GLU VAL ALA ILE ASP MET
SEQRES  40 B  587  LEU ALA THR SER ASN VAL PHE LEU PRO GLY HIS ARG ILE
SEQRES  41 B  587  MET VAL GLN VAL SER SER SER ASN PHE PRO LYS TYR ASP
SEQRES  42 B  587  ARG ASN SER ASN THR GLY GLY VAL ILE ALA ARG GLU GLN
SEQRES  43 B  587  LEU GLU GLU MET CYS THR ALA VAL ASN ARG ILE HIS ARG
SEQRES  44 B  587  GLY PRO GLU HIS PRO SER HIS ILE VAL LEU PRO ILE ILE
SEQRES  45 B  587  LYS ARG LYS LEU ALA ALA ALA LEU GLU HIS HIS HIS HIS
SEQRES  46 B  587  HIS HIS
HET    GOL  A 588       6
HET    GOL  A 589       6
HET    SO4  A 590       5
HET    SO4  A 591       5
HET    SO4  A 592       5
HET    GOL  B 588       6
HET    SO4  B 589       5
HETNAM     GOL GLYCEROL
HETNAM     SO4 SULFATE ION
HETSYN     GOL GLYCERIN; PROPANE-1,2,3-TRIOL
FORMUL   3  GOL    3(C3 H8 O3)
FORMUL   5  SO4    4(O4 S 2-)
FORMUL  10  HOH   *778(H2 O)
HELIX    1   1 VAL A   49  THR A   54  1                                   6
HELIX    2   2 TRP A   59  ASP A   65  1                                   7
HELIX    3   3 ASP A   89  GLN A  104  1                                  16
HELIX    4   4 SER A  117  VAL A  128  1                                  12
HELIX    5   5 SER A  159  SER A  177  1                                  19
HELIX    6   6 GLU A  184  ASP A  198  1                                  15
HELIX    7   7 ASP A  198  SER A  204  1                                   7
HELIX    8   8 LEU A  213  ILE A  218  1                                   6
HELIX    9   9 PRO A  219  GLN A  224  1                                   6
HELIX   10  10 ASP A  232  SER A  237  1                                   6
HELIX   11  11 ILE A  238  SER A  239  5                                   2
HELIX   12  12 LEU A  240  LEU A  244  5                                   5
HELIX   13  13 PHE A  261  LYS A  273  1                                  13
HELIX   14  14 GLY A  300  THR A  304  5                                   5
HELIX   15  15 PRO A  306  ARG A  323  1                                  18
HELIX   16  16 ARG A  484  ARG A  486  5                                   3
HELIX   17  17 VAL A  541  GLU A  545  5                                   5
HELIX   18  18 GLN A  546  MET A  550  5                                   5
HELIX   19  19 VAL B   49  THR B   54  1                                   6
HELIX   20  20 TRP B   59  ASP B   65  1                                   7
HELIX   21  21 ASP B   89  GLU B  103  1                                  15
HELIX   22  22 SER B  117  VAL B  128  1                                  12
HELIX   23  23 SER B  159  SER B  177  1                                  19
HELIX   24  24 GLU B  184  ASN B  197  1                                  14
HELIX   25  25 ASP B  198  ALA B  203  1                                   6
HELIX   26  26 LEU B  213  ILE B  218  1                                   6
HELIX   27  27 PRO B  219  GLN B  224  1                                   6
HELIX   28  28 ASP B  232  SER B  237  1                                   6
HELIX   29  29 ILE B  238  SER B  239  5                                   2
HELIX   30  30 LEU B  240  LEU B  247  5                                   8
HELIX   31  31 PHE B  261  LYS B  273  1                                  13
HELIX   32  32 GLY B  300  THR B  304  5                                   5
HELIX   33  33 PRO B  306  LEU B  322  1                                  17
HELIX   34  34 GLN B  418  HIS B  422  5                                   5
HELIX   35  35 ARG B  484  ARG B  486  5                                   3
HELIX   36  36 VAL B  541  GLU B  545  5                                   5
HELIX   37  37 GLN B  546  MET B  550  5                                   5
SHEET    1   A12 LEU A 134  ALA A 136  0
SHEET    2   A12 CYS A 107  MET A 113  1  N  VAL A 111   O  LYS A 135
SHEET    3   A12 VAL A  35  ASN A  42  1  N  VAL A  35   O  ASP A 108
SHEET    4   A12 ALA A  68  ASP A  73  1  O  VAL A  70   N  LEU A  38
SHEET    5   A12 ARG A  21  PRO A  29 -1  N  TYR A  27   O  VAL A  69
SHEET    6   A12 TYR A   6  PRO A  15 -1  N  ALA A   9   O  LEU A  26
SHEET    7   A12 TYR B   6  PRO B  15 -1  O  TYR B   6   N  VAL A   8
SHEET    8   A12 ARG B  21  PRO B  29 -1  O  LEU B  22   N  VAL B  14
SHEET    9   A12 ALA B  68  ASP B  73 -1  O  VAL B  69   N  TYR B  27
SHEET   10   A12 VAL B  35  ASN B  42  1  N  LEU B  38   O  VAL B  70
SHEET   11   A12 CYS B 107  MET B 113  1  O  ASP B 108   N  VAL B  35
SHEET   12   A12 LEU B 134  ALA B 136  1  O  LYS B 135   N  VAL B 111
SHEET    1   B 2 GLY A 115  VAL A 116  0
SHEET    2   B 2 PRO A 139  SER A 140  1  O  SER A 140   N  GLY A 115
SHEET    1   C 4 LEU A 252  GLY A 256  0
SHEET    2   C 4 ARG A 279  GLY A 283  1  O  ARG A 279   N  ILE A 253
SHEET    3   C 4 VAL A 335  VAL A 339  1  O  ARG A 336   N  VAL A 282
SHEET    4   C 4 GLU A 344  GLU A 348 -1  O  GLU A 344   N  VAL A 339
SHEET    1   D 2 ARG A 293  ASN A 294  0
SHEET    2   D 2 ARG A 297  LYS A 298 -1  O  ARG A 297   N  ASN A 294
SHEET    1   E10 SER A 387  TYR A 393  0
SHEET    2   E10 ALA A 553  ARG A 559 -1  O  ARG A 559   N  SER A 387
SHEET    3   E10 VAL A 439  SER A 453 -1  N  PHE A 450   O  HIS A 558
SHEET    4   E10 HIS A 566  ILE A 572 -1  O  VAL A 568   N  SER A 446
SHEET    5   E10 ALA A 357  GLY A 364 -1  N  THR A 359   O  LEU A 569
SHEET    6   E10 GLY A 376  SER A 379 -1  O  SER A 379   N  TYR A 362
SHEET    7   E10 LEU A 428  SER A 431  1  O  SER A 431   N  GLY A 376
SHEET    8   E10 ARG A 519  SER A 525 -1  O  VAL A 524   N  LEU A 428
SHEET    9   E10 ASP A 459  VAL A 467 -1  N  VAL A 465   O  MET A 521
SHEET   10   E10 ALA A 473  ARG A 482 -1  O  ILE A 474   N  ASP A 466
SHEET    1   F 4 SER A 387  TYR A 393  0
SHEET    2   F 4 ALA A 553  ARG A 559 -1  O  ARG A 559   N  SER A 387
SHEET    3   F 4 VAL A 439  SER A 453 -1  N  PHE A 450   O  HIS A 558
SHEET    4   F 4 TYR A 501  PHE A 514 -1  O  TYR A 501   N  VAL A 451
SHEET    1   G 2 GLY B 115  VAL B 116  0
SHEET    2   G 2 PRO B 139  SER B 140  1  O  SER B 140   N  GLY B 115
SHEET    1   H 4 ALA B 251  GLY B 256  0
SHEET    2   H 4 ALA B 278  GLY B 283  1  O  ARG B 279   N  ILE B 253
SHEET    3   H 4 VAL B 335  VAL B 339  1  O  ARG B 336   N  VAL B 282
SHEET    4   H 4 GLU B 344  GLU B 348 -1  O  GLU B 348   N  VAL B 335
SHEET    1   I 6 THR B 377  SER B 379  0
SHEET    2   I 6 ALA B 357  GLY B 364 -1  N  TYR B 362   O  SER B 379
SHEET    3   I 6 HIS B 566  ILE B 572 -1  O  LEU B 569   N  THR B 359
SHEET    4   I 6 VAL B 439  SER B 453 -1  N  ARG B 448   O  HIS B 566
SHEET    5   I 6 ALA B 553  ARG B 559 -1  O  HIS B 558   N  PHE B 450
SHEET    6   I 6 SER B 387  TYR B 393 -1  N  SER B 387   O  ARG B 559
SHEET    1   J 5 THR B 377  SER B 379  0
SHEET    2   J 5 ALA B 357  GLY B 364 -1  N  TYR B 362   O  SER B 379
SHEET    3   J 5 HIS B 566  ILE B 572 -1  O  LEU B 569   N  THR B 359
SHEET    4   J 5 VAL B 439  SER B 453 -1  N  ARG B 448   O  HIS B 566
SHEET    5   J 5 TYR B 501  PHE B 514 -1  O  PHE B 514   N  VAL B 439
SHEET    1   K 4 LEU B 428  SER B 431  0
SHEET    2   K 4 ARG B 519  SER B 525 -1  O  VAL B 522   N  TYR B 430
SHEET    3   K 4 ASP B 459  VAL B 467 -1  N  THR B 461   O  SER B 525
SHEET    4   K 4 ALA B 473  ARG B 482 -1  O  ILE B 474   N  ASP B 466
CISPEP   1 ALA A  149    PRO A  150          0        10.61
CISPEP   2 THR A  206    PRO A  207          0        -1.26
CISPEP   3 TRP A  351    PRO A  352          0        -5.33
CISPEP   4 PHE A  529    PRO A  530          0         6.60
CISPEP   5 ALA B  149    PRO B  150          0        11.69
CISPEP   6 THR B  206    PRO B  207          0        -4.28
CISPEP   7 TRP B  351    PRO B  352          0        -3.34
CISPEP   8 PHE B  529    PRO B  530          0         5.53
SITE     1 AC1  9 ASN A 197  VAL A 199  PHE A 408  HIS A 409
SITE     2 AC1  9 ASN A 410  HOH A 657  HOH A 740  ARG B 293
SITE     3 AC1  9 LYS B 298
SITE     1 AC2  7 VAL A 554  ARG A 556  HOH A 707  HOH A 972
SITE     2 AC2  7 SER B 452  SER B 454  VAL B 554
SITE     1 AC3  1 GLU B 103
SITE     1 AC4  2 ASP A 296  ASP B 296
SITE     1 AC5  3 ASP A 319  ARG A 323  GLU A 325
SITE     1 AC6  7 ARG A 293  LYS A 298  LEU B 196  VAL B 199
SITE     2 AC6  7 PHE B 408  HIS B 409  ASN B 410
SITE     1 AC7  3 ASP B  65  ASP B 319  GLU B 325
CRYST1   73.345  105.442  224.518  90.00  90.00  90.00 P 21 21 21    8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.013634  0.000000  0.000000        0.00000
SCALE2      0.000000  0.009484  0.000000        0.00000
SCALE3      0.000000  0.000000  0.004454        0.00000
TER    4389      ARG A 574
TER    8821      ARG B 574
MASTER      391    0    7   37   55    0   11    6 9557    2   38   92
END