longtext: 3R3Z-pdb

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HEADER    HYDROLASE                               16-MAR-11   3R3Z
TITLE     CRYSTAL STRUCTURE OF THE FLUOROACETATE DEHALOGENASE RPA1163 -
TITLE    2 WT/GLYCOLATE
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: FLUOROACETATE DEHALOGENASE;
COMPND   3 CHAIN: A, B, C, D;
COMPND   4 EC: 3.8.1.3;
COMPND   5 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: RHODOPSEUDOMONAS PALUSTRIS;
SOURCE   3 ORGANISM_TAXID: 1076;
SOURCE   4 STRAIN: CGA009;
SOURCE   5 GENE: RPA1163;
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: P15TV-L
KEYWDS    FACD, DEFLUORINASE, ALPHA/BETA HYDROLASE, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    P.W.Y.CHAN,A.F.YAKUNIN,E.A.EDWARDS,E.F.PAI
REVDAT   1   04-MAY-11 3R3Z    0
JRNL        AUTH   P.W.CHAN,A.F.YAKUNIN,E.A.EDWARDS,E.F.PAI
JRNL        TITL   MAPPING THE REACTION COORDINATES OF ENZYMATIC
JRNL        TITL 2 DEFLUORINATION.
JRNL        REF    J.AM.CHEM.SOC.                             2011
JRNL        REFN                   ESSN 1520-5126
JRNL        PMID   21510690
JRNL        DOI    10.1021/JA200277D
REMARK   2
REMARK   2 RESOLUTION.    1.70 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.5.0102
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.70
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 18.23
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.7
REMARK   3   NUMBER OF REFLECTIONS             : 141042
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.179
REMARK   3   R VALUE            (WORKING SET) : 0.177
REMARK   3   FREE R VALUE                     : 0.218
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000
REMARK   3   FREE R VALUE TEST SET COUNT      : 7083
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 1.70
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 1.74
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 9741
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 98.01
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2980
REMARK   3   BIN FREE R VALUE SET COUNT          : 501
REMARK   3   BIN FREE R VALUE                    : 0.3480
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 9458
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 23
REMARK   3   SOLVENT ATOMS            : 1068
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 24.04
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 17.80
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : 0.21000
REMARK   3    B22 (A**2) : -0.50000
REMARK   3    B33 (A**2) : 0.29000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): NULL
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.107
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.069
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 2.097
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.948
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.927
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  9934 ; 0.025 ; 0.021
REMARK   3   BOND LENGTHS OTHERS               (A):  6818 ; 0.001 ; 0.020
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 13542 ; 1.963 ; 1.942
REMARK   3   BOND ANGLES OTHERS          (DEGREES): 16427 ; 1.067 ; 3.000
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  1221 ; 6.410 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   467 ;32.163 ;22.570
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  1489 ;13.832 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    78 ;16.679 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  1373 ; 0.131 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A): 11285 ; 0.012 ; 0.021
REMARK   3   GENERAL PLANES OTHERS             (A):  2198 ; 0.002 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  6066 ; 1.297 ; 1.500
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  2417 ; 0.444 ; 1.500
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  9705 ; 2.069 ; 2.000
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  3868 ; 3.089 ; 3.000
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  3837 ; 4.654 ; 4.500
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.40
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING
REMARK   3  POSITIONS U VALUES: REFINED INDIVIDUALLY
REMARK   4
REMARK   4 3R3Z COMPLIES WITH FORMAT V. 3.20, 01-DEC-08
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 23-MAR-11.
REMARK 100 THE RCSB ID CODE IS RCSB064459.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 06-AUG-06
REMARK 200  TEMPERATURE           (KELVIN) : NULL
REMARK 200  PH                             : 6.5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : APS
REMARK 200  BEAMLINE                       : 14-BM-C
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.90020
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : NULL
REMARK 200  DETECTOR MANUFACTURER          : NULL
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : XSCALE
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 177077
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.570
REMARK 200  RESOLUTION RANGE LOW       (A) : 89.800
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : -3.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 96.9
REMARK 200  DATA REDUNDANCY                : NULL
REMARK 200  R MERGE                    (I) : 0.06400
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 17.9100
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.57
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.61
REMARK 200  COMPLETENESS FOR SHELL     (%) : 78.6
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : 0.68400
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 2.240
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 48.23
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.38
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 16-20% PEG3350, 0.2M NH4CL, 0.1M
REMARK 280  SODIUM CACODYLATE. MICROSEEDED USING PARENT CRYSTALS GROWN WITH
REMARK 280  THE SUPPLEMENTATION OF 4% SUCROSE, PH 6.5, VAPOR DIFFUSION,
REMARK 280  HANGING DROP, TEMPERATURE 298K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X+1/2,-Y,Z+1/2
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       40.04000
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       66.23000
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       61.06000
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       66.23000
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       40.04000
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       61.06000
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 3000 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 21590 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -22.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 2910 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 20930 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -15.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     GLY A   303
REMARK 465     SER A   304
REMARK 465     GLY B   252
REMARK 465     ILE B   253
REMARK 465     ALA B   254
REMARK 465     GLN B   255
REMARK 465     SER B   256
REMARK 465     ALA B   257
REMARK 465     ALA B   258
REMARK 465     THR B   259
REMARK 465     PRO B   302
REMARK 465     GLY B   303
REMARK 465     SER B   304
REMARK 465     ALA C   300
REMARK 465     ALA C   301
REMARK 465     PRO C   302
REMARK 465     GLY C   303
REMARK 465     SER C   304
REMARK 465     GLY D    -1
REMARK 465     HIS D     0
REMARK 465     MET D     1
REMARK 465     PRO D     2
REMARK 465     ASP D     3
REMARK 465     LEU D     4
REMARK 465     ALA D   301
REMARK 465     PRO D   302
REMARK 465     GLY D   303
REMARK 465     SER D   304
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   O    HOH B   838     O    HOH B   839              1.87
REMARK 500   O    HOH C   992     O    HOH C  1151              1.99
REMARK 500   O    LEU D   127     O    HOH D  1199              2.02
REMARK 500   O    HOH A   378     O    HOH A   418              2.13
REMARK 500   OE1  GLU A   235     O    HOH A  1182              2.15
REMARK 500   O    HOH B   409     O    HOH B   831              2.16
REMARK 500   NZ   LYS A   181     O    HOH A  1106              2.18
REMARK 500   O    HOH B  1299     O    HOH B  1337              2.19
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION
REMARK 500    GLU B 292   CG    GLU B 292   CD      0.099
REMARK 500    CYS D 216   CB    CYS D 216   SG     -0.110
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    MET A 244   CG  -  SD  -  CE  ANGL. DEV. = -12.7 DEGREES
REMARK 500    MET B   1   CG  -  SD  -  CE  ANGL. DEV. =  -9.7 DEGREES
REMARK 500    ASP B   3   CB  -  CG  -  OD1 ANGL. DEV. =   6.8 DEGREES
REMARK 500    ARG B 144   NE  -  CZ  -  NH1 ANGL. DEV. =  -3.7 DEGREES
REMARK 500    ASP B 218   CB  -  CG  -  OD2 ANGL. DEV. =   5.4 DEGREES
REMARK 500    ARG B 220   NE  -  CZ  -  NH2 ANGL. DEV. =   3.2 DEGREES
REMARK 500    ASP B 262   CB  -  CG  -  OD2 ANGL. DEV. =  -5.9 DEGREES
REMARK 500    ASP B 288   CB  -  CG  -  OD2 ANGL. DEV. =   5.7 DEGREES
REMARK 500    ASP C   6   CB  -  CG  -  OD1 ANGL. DEV. =   5.5 DEGREES
REMARK 500    ARG C  26   NE  -  CZ  -  NH2 ANGL. DEV. =   3.7 DEGREES
REMARK 500    ARG C  49   NE  -  CZ  -  NH2 ANGL. DEV. =   3.3 DEGREES
REMARK 500    ARG C  57   NE  -  CZ  -  NH1 ANGL. DEV. =  -4.3 DEGREES
REMARK 500    ARG C  57   NE  -  CZ  -  NH2 ANGL. DEV. =   3.6 DEGREES
REMARK 500    MET C 145   CG  -  SD  -  CE  ANGL. DEV. =  12.2 DEGREES
REMARK 500    ASP C 175   CB  -  CG  -  OD2 ANGL. DEV. =  -6.4 DEGREES
REMARK 500    MET D 145   CG  -  SD  -  CE  ANGL. DEV. =  14.1 DEGREES
REMARK 500    ASP D 175   CB  -  CG  -  OD1 ANGL. DEV. =   5.7 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    PRO A   9      113.01    -37.96
REMARK 500    PRO A  41       62.58   -102.54
REMARK 500    ASP A 110     -126.12     55.45
REMARK 500    SER A 123       58.02   -140.10
REMARK 500    ILE A 153       51.67   -113.58
REMARK 500    ASP A 173       75.41   -165.03
REMARK 500    TYR A 224      -96.62   -121.13
REMARK 500    PRO B  41       60.53   -100.09
REMARK 500    ASP B 110     -127.49     56.48
REMARK 500    SER B 123       55.49   -142.47
REMARK 500    ASP B 173       67.76    179.17
REMARK 500    TYR B 224      -91.85   -121.77
REMARK 500    PRO C  41       63.48   -103.64
REMARK 500    ASP C 110     -130.71     58.73
REMARK 500    TYR C 224      -95.26   -124.85
REMARK 500    SER C 278      156.99    178.14
REMARK 500    PRO D   9      101.11    -30.69
REMARK 500    PRO D  41       60.41   -102.56
REMARK 500    ASP D 110     -126.71     56.25
REMARK 500    ASP D 173       76.80   -166.98
REMARK 500    TYR D 224      -96.66   -119.51
REMARK 500    ALA D 258     -177.84   -170.69
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH A1172        DISTANCE =  5.39 ANGSTROMS
REMARK 525    HOH B1309        DISTANCE =  5.70 ANGSTROMS
REMARK 525    HOH B1311        DISTANCE =  5.07 ANGSTROMS
REMARK 525    HOH C1308        DISTANCE =  5.06 ANGSTROMS
REMARK 525    HOH D1353        DISTANCE =  6.31 ANGSTROMS
REMARK 620
REMARK 620 METAL COORDINATION
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              NI C 306  NI
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 HIS C   0   N
REMARK 620 2 HIS C   0   ND1 100.0
REMARK 620 3 HOH C1261   O   100.2  92.0
REMARK 620 4 GLY C  -1   N    75.6 173.2  93.8
REMARK 620 N                    1     2     3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              NI A 306  NI
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 HIS A   0   N
REMARK 620 2 HIS A   0   ND1  98.4
REMARK 620 3 GLY A  -1   N    75.6 173.4
REMARK 620 4 HOH A1262   O    89.1  91.9  85.5
REMARK 620 N                    1     2     3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              NI B 306  NI
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 HIS B   0   ND1
REMARK 620 2 HIS B   0   N    91.4
REMARK 620 3 GLY B  -1   N   172.1  80.8
REMARK 620 4 HOH B1264   O    87.6  94.0  92.8
REMARK 620 5 HOH B1263   O    94.3  91.2  86.0 174.5
REMARK 620 N                    1     2     3     4
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOA A 305
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NI A 306
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOA B 305
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NI B 306
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOA C 305
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NI C 306
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOA D 305
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 3R3U   RELATED DB: PDB
REMARK 900 THE WT/APO CRYSTAL STRUCTURE.
REMARK 900 RELATED ID: 3R3V   RELATED DB: PDB
REMARK 900 THE ASP110ASN MUTANT IN COMPLEX WITH FLUOROACETATE.
REMARK 900 RELATED ID: 3R3W   RELATED DB: PDB
REMARK 900 THE ASP110ASN MUTANT IN COMPLEX WITH CHLOROACETATE.
REMARK 900 RELATED ID: 3R3X   RELATED DB: PDB
REMARK 900 THE ASP110ASN MUTANT IN COMPLEX WITH BROMOACETATE.
REMARK 900 RELATED ID: 3R3Y   RELATED DB: PDB
REMARK 900 THE HIS280ASN MUTANT IN COVALENT COMPLEX WITH FLUOROACETATE.
REMARK 900 RELATED ID: 3R40   RELATED DB: PDB
REMARK 900 THE ASP110ASN MUTANT/APO CRYSTAL STRUCTURE
REMARK 900 RELATED ID: 3R41   RELATED DB: PDB
REMARK 900 THE HIS280ASN MUTANT/APO CRYSTAL STRUCTURE
DBREF  3R3Z A    1   302  UNP    Q6NAM1   DEHA_RHOPA       1    302
DBREF  3R3Z B    1   302  UNP    Q6NAM1   DEHA_RHOPA       1    302
DBREF  3R3Z C    1   302  UNP    Q6NAM1   DEHA_RHOPA       1    302
DBREF  3R3Z D    1   302  UNP    Q6NAM1   DEHA_RHOPA       1    302
SEQADV 3R3Z GLY A   -1  UNP  Q6NAM1              EXPRESSION TAG
SEQADV 3R3Z HIS A    0  UNP  Q6NAM1              EXPRESSION TAG
SEQADV 3R3Z GLY A  303  UNP  Q6NAM1              EXPRESSION TAG
SEQADV 3R3Z SER A  304  UNP  Q6NAM1              EXPRESSION TAG
SEQADV 3R3Z GLY B   -1  UNP  Q6NAM1              EXPRESSION TAG
SEQADV 3R3Z HIS B    0  UNP  Q6NAM1              EXPRESSION TAG
SEQADV 3R3Z GLY B  303  UNP  Q6NAM1              EXPRESSION TAG
SEQADV 3R3Z SER B  304  UNP  Q6NAM1              EXPRESSION TAG
SEQADV 3R3Z GLY C   -1  UNP  Q6NAM1              EXPRESSION TAG
SEQADV 3R3Z HIS C    0  UNP  Q6NAM1              EXPRESSION TAG
SEQADV 3R3Z GLY C  303  UNP  Q6NAM1              EXPRESSION TAG
SEQADV 3R3Z SER C  304  UNP  Q6NAM1              EXPRESSION TAG
SEQADV 3R3Z GLY D   -1  UNP  Q6NAM1              EXPRESSION TAG
SEQADV 3R3Z HIS D    0  UNP  Q6NAM1              EXPRESSION TAG
SEQADV 3R3Z GLY D  303  UNP  Q6NAM1              EXPRESSION TAG
SEQADV 3R3Z SER D  304  UNP  Q6NAM1              EXPRESSION TAG
SEQRES   1 A  306  GLY HIS MET PRO ASP LEU ALA ASP LEU PHE PRO GLY PHE
SEQRES   2 A  306  GLY SER GLU TRP ILE ASN THR SER SER GLY ARG ILE PHE
SEQRES   3 A  306  ALA ARG VAL GLY GLY ASP GLY PRO PRO LEU LEU LEU LEU
SEQRES   4 A  306  HIS GLY PHE PRO GLN THR HIS VAL MET TRP HIS ARG VAL
SEQRES   5 A  306  ALA PRO LYS LEU ALA GLU ARG PHE LYS VAL ILE VAL ALA
SEQRES   6 A  306  ASP LEU PRO GLY TYR GLY TRP SER ASP MET PRO GLU SER
SEQRES   7 A  306  ASP GLU GLN HIS THR PRO TYR THR LYS ARG ALA MET ALA
SEQRES   8 A  306  LYS GLN LEU ILE GLU ALA MET GLU GLN LEU GLY HIS VAL
SEQRES   9 A  306  HIS PHE ALA LEU ALA GLY HIS ASP ARG GLY ALA ARG VAL
SEQRES  10 A  306  SER TYR ARG LEU ALA LEU ASP SER PRO GLY ARG LEU SER
SEQRES  11 A  306  LYS LEU ALA VAL LEU ASP ILE LEU PRO THR TYR GLU TYR
SEQRES  12 A  306  TRP GLN ARG MET ASN ARG ALA TYR ALA LEU LYS ILE TYR
SEQRES  13 A  306  HIS TRP SER PHE LEU ALA GLN PRO ALA PRO LEU PRO GLU
SEQRES  14 A  306  ASN LEU LEU GLY GLY ASP PRO ASP PHE TYR VAL LYS ALA
SEQRES  15 A  306  LYS LEU ALA SER TRP THR ARG ALA GLY ASP LEU SER ALA
SEQRES  16 A  306  PHE ASP PRO ARG ALA VAL GLU HIS TYR ARG ILE ALA PHE
SEQRES  17 A  306  ALA ASP PRO MET ARG ARG HIS VAL MET CYS GLU ASP TYR
SEQRES  18 A  306  ARG ALA GLY ALA TYR ALA ASP PHE GLU HIS ASP LYS ILE
SEQRES  19 A  306  ASP VAL GLU ALA GLY ASN LYS ILE PRO VAL PRO MET LEU
SEQRES  20 A  306  ALA LEU TRP GLY ALA SER GLY ILE ALA GLN SER ALA ALA
SEQRES  21 A  306  THR PRO LEU ASP VAL TRP ARG LYS TRP ALA SER ASP VAL
SEQRES  22 A  306  GLN GLY ALA PRO ILE GLU SER GLY HIS PHE LEU PRO GLU
SEQRES  23 A  306  GLU ALA PRO ASP GLN THR ALA GLU ALA LEU VAL ARG PHE
SEQRES  24 A  306  PHE SER ALA ALA PRO GLY SER
SEQRES   1 B  306  GLY HIS MET PRO ASP LEU ALA ASP LEU PHE PRO GLY PHE
SEQRES   2 B  306  GLY SER GLU TRP ILE ASN THR SER SER GLY ARG ILE PHE
SEQRES   3 B  306  ALA ARG VAL GLY GLY ASP GLY PRO PRO LEU LEU LEU LEU
SEQRES   4 B  306  HIS GLY PHE PRO GLN THR HIS VAL MET TRP HIS ARG VAL
SEQRES   5 B  306  ALA PRO LYS LEU ALA GLU ARG PHE LYS VAL ILE VAL ALA
SEQRES   6 B  306  ASP LEU PRO GLY TYR GLY TRP SER ASP MET PRO GLU SER
SEQRES   7 B  306  ASP GLU GLN HIS THR PRO TYR THR LYS ARG ALA MET ALA
SEQRES   8 B  306  LYS GLN LEU ILE GLU ALA MET GLU GLN LEU GLY HIS VAL
SEQRES   9 B  306  HIS PHE ALA LEU ALA GLY HIS ASP ARG GLY ALA ARG VAL
SEQRES  10 B  306  SER TYR ARG LEU ALA LEU ASP SER PRO GLY ARG LEU SER
SEQRES  11 B  306  LYS LEU ALA VAL LEU ASP ILE LEU PRO THR TYR GLU TYR
SEQRES  12 B  306  TRP GLN ARG MET ASN ARG ALA TYR ALA LEU LYS ILE TYR
SEQRES  13 B  306  HIS TRP SER PHE LEU ALA GLN PRO ALA PRO LEU PRO GLU
SEQRES  14 B  306  ASN LEU LEU GLY GLY ASP PRO ASP PHE TYR VAL LYS ALA
SEQRES  15 B  306  LYS LEU ALA SER TRP THR ARG ALA GLY ASP LEU SER ALA
SEQRES  16 B  306  PHE ASP PRO ARG ALA VAL GLU HIS TYR ARG ILE ALA PHE
SEQRES  17 B  306  ALA ASP PRO MET ARG ARG HIS VAL MET CYS GLU ASP TYR
SEQRES  18 B  306  ARG ALA GLY ALA TYR ALA ASP PHE GLU HIS ASP LYS ILE
SEQRES  19 B  306  ASP VAL GLU ALA GLY ASN LYS ILE PRO VAL PRO MET LEU
SEQRES  20 B  306  ALA LEU TRP GLY ALA SER GLY ILE ALA GLN SER ALA ALA
SEQRES  21 B  306  THR PRO LEU ASP VAL TRP ARG LYS TRP ALA SER ASP VAL
SEQRES  22 B  306  GLN GLY ALA PRO ILE GLU SER GLY HIS PHE LEU PRO GLU
SEQRES  23 B  306  GLU ALA PRO ASP GLN THR ALA GLU ALA LEU VAL ARG PHE
SEQRES  24 B  306  PHE SER ALA ALA PRO GLY SER
SEQRES   1 C  306  GLY HIS MET PRO ASP LEU ALA ASP LEU PHE PRO GLY PHE
SEQRES   2 C  306  GLY SER GLU TRP ILE ASN THR SER SER GLY ARG ILE PHE
SEQRES   3 C  306  ALA ARG VAL GLY GLY ASP GLY PRO PRO LEU LEU LEU LEU
SEQRES   4 C  306  HIS GLY PHE PRO GLN THR HIS VAL MET TRP HIS ARG VAL
SEQRES   5 C  306  ALA PRO LYS LEU ALA GLU ARG PHE LYS VAL ILE VAL ALA
SEQRES   6 C  306  ASP LEU PRO GLY TYR GLY TRP SER ASP MET PRO GLU SER
SEQRES   7 C  306  ASP GLU GLN HIS THR PRO TYR THR LYS ARG ALA MET ALA
SEQRES   8 C  306  LYS GLN LEU ILE GLU ALA MET GLU GLN LEU GLY HIS VAL
SEQRES   9 C  306  HIS PHE ALA LEU ALA GLY HIS ASP ARG GLY ALA ARG VAL
SEQRES  10 C  306  SER TYR ARG LEU ALA LEU ASP SER PRO GLY ARG LEU SER
SEQRES  11 C  306  LYS LEU ALA VAL LEU ASP ILE LEU PRO THR TYR GLU TYR
SEQRES  12 C  306  TRP GLN ARG MET ASN ARG ALA TYR ALA LEU LYS ILE TYR
SEQRES  13 C  306  HIS TRP SER PHE LEU ALA GLN PRO ALA PRO LEU PRO GLU
SEQRES  14 C  306  ASN LEU LEU GLY GLY ASP PRO ASP PHE TYR VAL LYS ALA
SEQRES  15 C  306  LYS LEU ALA SER TRP THR ARG ALA GLY ASP LEU SER ALA
SEQRES  16 C  306  PHE ASP PRO ARG ALA VAL GLU HIS TYR ARG ILE ALA PHE
SEQRES  17 C  306  ALA ASP PRO MET ARG ARG HIS VAL MET CYS GLU ASP TYR
SEQRES  18 C  306  ARG ALA GLY ALA TYR ALA ASP PHE GLU HIS ASP LYS ILE
SEQRES  19 C  306  ASP VAL GLU ALA GLY ASN LYS ILE PRO VAL PRO MET LEU
SEQRES  20 C  306  ALA LEU TRP GLY ALA SER GLY ILE ALA GLN SER ALA ALA
SEQRES  21 C  306  THR PRO LEU ASP VAL TRP ARG LYS TRP ALA SER ASP VAL
SEQRES  22 C  306  GLN GLY ALA PRO ILE GLU SER GLY HIS PHE LEU PRO GLU
SEQRES  23 C  306  GLU ALA PRO ASP GLN THR ALA GLU ALA LEU VAL ARG PHE
SEQRES  24 C  306  PHE SER ALA ALA PRO GLY SER
SEQRES   1 D  306  GLY HIS MET PRO ASP LEU ALA ASP LEU PHE PRO GLY PHE
SEQRES   2 D  306  GLY SER GLU TRP ILE ASN THR SER SER GLY ARG ILE PHE
SEQRES   3 D  306  ALA ARG VAL GLY GLY ASP GLY PRO PRO LEU LEU LEU LEU
SEQRES   4 D  306  HIS GLY PHE PRO GLN THR HIS VAL MET TRP HIS ARG VAL
SEQRES   5 D  306  ALA PRO LYS LEU ALA GLU ARG PHE LYS VAL ILE VAL ALA
SEQRES   6 D  306  ASP LEU PRO GLY TYR GLY TRP SER ASP MET PRO GLU SER
SEQRES   7 D  306  ASP GLU GLN HIS THR PRO TYR THR LYS ARG ALA MET ALA
SEQRES   8 D  306  LYS GLN LEU ILE GLU ALA MET GLU GLN LEU GLY HIS VAL
SEQRES   9 D  306  HIS PHE ALA LEU ALA GLY HIS ASP ARG GLY ALA ARG VAL
SEQRES  10 D  306  SER TYR ARG LEU ALA LEU ASP SER PRO GLY ARG LEU SER
SEQRES  11 D  306  LYS LEU ALA VAL LEU ASP ILE LEU PRO THR TYR GLU TYR
SEQRES  12 D  306  TRP GLN ARG MET ASN ARG ALA TYR ALA LEU LYS ILE TYR
SEQRES  13 D  306  HIS TRP SER PHE LEU ALA GLN PRO ALA PRO LEU PRO GLU
SEQRES  14 D  306  ASN LEU LEU GLY GLY ASP PRO ASP PHE TYR VAL LYS ALA
SEQRES  15 D  306  LYS LEU ALA SER TRP THR ARG ALA GLY ASP LEU SER ALA
SEQRES  16 D  306  PHE ASP PRO ARG ALA VAL GLU HIS TYR ARG ILE ALA PHE
SEQRES  17 D  306  ALA ASP PRO MET ARG ARG HIS VAL MET CYS GLU ASP TYR
SEQRES  18 D  306  ARG ALA GLY ALA TYR ALA ASP PHE GLU HIS ASP LYS ILE
SEQRES  19 D  306  ASP VAL GLU ALA GLY ASN LYS ILE PRO VAL PRO MET LEU
SEQRES  20 D  306  ALA LEU TRP GLY ALA SER GLY ILE ALA GLN SER ALA ALA
SEQRES  21 D  306  THR PRO LEU ASP VAL TRP ARG LYS TRP ALA SER ASP VAL
SEQRES  22 D  306  GLN GLY ALA PRO ILE GLU SER GLY HIS PHE LEU PRO GLU
SEQRES  23 D  306  GLU ALA PRO ASP GLN THR ALA GLU ALA LEU VAL ARG PHE
SEQRES  24 D  306  PHE SER ALA ALA PRO GLY SER
HET    GOA  A 305       5
HET     NI  A 306       1
HET    GOA  B 305       5
HET     NI  B 306       1
HET    GOA  C 305       5
HET     NI  C 306       1
HET    GOA  D 305       5
HETNAM     GOA GLYCOLIC ACID
HETNAM      NI NICKEL (II) ION
HETSYN     GOA HYDROXYACETIC ACID; HYDROXYETHANOIC ACID
FORMUL   5  GOA    4(C2 H4 O3)
FORMUL   6   NI    3(NI 2+)
FORMUL  12  HOH   *1068(H2 O)
HELIX    1   1 THR A   43  HIS A   48  5                                   6
HELIX    2   2 VAL A   50  GLU A   56  1                                   7
HELIX    3   3 HIS A   80  TYR A   83  5                                   4
HELIX    4   4 THR A   84  LEU A   99  1                                  16
HELIX    5   5 ASP A  110  SER A  123  1                                  14
HELIX    6   6 PRO A  137  ARG A  144  1                                   8
HELIX    7   7 ASN A  146  ILE A  153  1                                   8
HELIX    8   8 TYR A  154  LEU A  159  1                                   6
HELIX    9   9 PRO A  164  GLY A  171  1                                   8
HELIX   10  10 ASP A  173  TRP A  185  1                                  13
HELIX   11  11 ASP A  195  ALA A  207  1                                  13
HELIX   12  12 ASP A  208  TYR A  224  1                                  17
HELIX   13  13 TYR A  224  GLY A  237  1                                  14
HELIX   14  14 ILE A  253  ALA A  258  1                                   6
HELIX   15  15 THR A  259  ALA A  268  1                                  10
HELIX   16  16 PHE A  281  ALA A  286  1                                   6
HELIX   17  17 ALA A  286  SER A  299  1                                  14
HELIX   18  18 THR B   43  HIS B   48  5                                   6
HELIX   19  19 VAL B   50  ALA B   55  1                                   6
HELIX   20  20 HIS B   80  TYR B   83  5                                   4
HELIX   21  21 THR B   84  LEU B   99  1                                  16
HELIX   22  22 ASP B  110  SER B  123  1                                  14
HELIX   23  23 PRO B  137  ARG B  144  1                                   8
HELIX   24  24 ASN B  146  ILE B  153  1                                   8
HELIX   25  25 ILE B  153  LEU B  159  1                                   7
HELIX   26  26 PRO B  164  GLY B  171  1                                   8
HELIX   27  27 ASP B  173  TRP B  185  1                                  13
HELIX   28  28 ASP B  195  ALA B  207  1                                  13
HELIX   29  29 ASP B  208  TYR B  224  1                                  17
HELIX   30  30 TYR B  224  ALA B  236  1                                  13
HELIX   31  31 PRO B  260  ALA B  268  1                                   9
HELIX   32  32 PHE B  281  ALA B  286  1                                   6
HELIX   33  33 ALA B  286  ALA B  301  1                                  16
HELIX   34  34 THR C   43  HIS C   48  5                                   6
HELIX   35  35 VAL C   50  GLU C   56  1                                   7
HELIX   36  36 HIS C   80  TYR C   83  5                                   4
HELIX   37  37 THR C   84  LEU C   99  1                                  16
HELIX   38  38 ASP C  110  SER C  123  1                                  14
HELIX   39  39 PRO C  137  ARG C  144  1                                   8
HELIX   40  40 ASN C  146  ILE C  153  1                                   8
HELIX   41  41 TYR C  154  LEU C  159  1                                   6
HELIX   42  42 PRO C  164  GLY C  171  1                                   8
HELIX   43  43 ASP C  173  TRP C  185  1                                  13
HELIX   44  44 ASP C  195  ALA C  207  1                                  13
HELIX   45  45 ASP C  208  TYR C  224  1                                  17
HELIX   46  46 TYR C  224  GLY C  237  1                                  14
HELIX   47  47 THR C  259  ALA C  268  1                                  10
HELIX   48  48 PHE C  281  ALA C  286  1                                   6
HELIX   49  49 ALA C  286  SER C  299  1                                  14
HELIX   50  50 THR D   43  HIS D   48  5                                   6
HELIX   51  51 VAL D   50  ALA D   55  1                                   6
HELIX   52  52 HIS D   80  TYR D   83  5                                   4
HELIX   53  53 THR D   84  LEU D   99  1                                  16
HELIX   54  54 ASP D  110  SER D  123  1                                  14
HELIX   55  55 PRO D  137  ARG D  144  1                                   8
HELIX   56  56 ASN D  146  ILE D  153  1                                   8
HELIX   57  57 TYR D  154  LEU D  159  1                                   6
HELIX   58  58 PRO D  164  GLY D  171  1                                   8
HELIX   59  59 ASP D  173  TRP D  185  1                                  13
HELIX   60  60 ASP D  195  ALA D  207  1                                  13
HELIX   61  61 ASP D  208  TYR D  224  1                                  17
HELIX   62  62 TYR D  224  GLY D  237  1                                  14
HELIX   63  63 ILE D  253  ALA D  258  1                                   6
HELIX   64  64 THR D  259  ALA D  268  1                                  10
HELIX   65  65 PHE D  281  ALA D  286  1                                   6
HELIX   66  66 ALA D  286  ALA D  300  1                                  15
SHEET    1   A 8 GLY A  12  ILE A  16  0
SHEET    2   A 8 ILE A  23  GLY A  29 -1  O  ILE A  23   N  ILE A  16
SHEET    3   A 8 LYS A  59  ALA A  63 -1  O  VAL A  62   N  ARG A  26
SHEET    4   A 8 PRO A  33  LEU A  37  1  N  LEU A  34   O  ILE A  61
SHEET    5   A 8 PHE A 104  HIS A 109  1  O  ALA A 107   N  LEU A  35
SHEET    6   A 8 LEU A 127  LEU A 133  1  O  ALA A 131   N  LEU A 106
SHEET    7   A 8 MET A 244  GLY A 249  1  O  LEU A 245   N  VAL A 132
SHEET    8   A 8 VAL A 271  ILE A 276  1  O  GLN A 272   N  ALA A 246
SHEET    1   B 8 GLY B  12  ILE B  16  0
SHEET    2   B 8 ILE B  23  GLY B  29 -1  O  VAL B  27   N  GLY B  12
SHEET    3   B 8 LYS B  59  ALA B  63 -1  O  VAL B  62   N  ARG B  26
SHEET    4   B 8 PRO B  33  LEU B  37  1  N  LEU B  36   O  ILE B  61
SHEET    5   B 8 PHE B 104  HIS B 109  1  O  HIS B 109   N  LEU B  37
SHEET    6   B 8 LEU B 127  LEU B 133  1  O  LEU B 133   N  GLY B 108
SHEET    7   B 8 MET B 244  GLY B 249  1  O  LEU B 245   N  VAL B 132
SHEET    8   B 8 VAL B 271  ILE B 276  1  O  GLN B 272   N  ALA B 246
SHEET    1   C 8 GLY C  12  ILE C  16  0
SHEET    2   C 8 ILE C  23  GLY C  29 -1  O  ILE C  23   N  ILE C  16
SHEET    3   C 8 LYS C  59  ALA C  63 -1  O  VAL C  62   N  ARG C  26
SHEET    4   C 8 PRO C  33  LEU C  37  1  N  LEU C  34   O  ILE C  61
SHEET    5   C 8 PHE C 104  HIS C 109  1  O  ALA C 107   N  LEU C  37
SHEET    6   C 8 LEU C 127  LEU C 133  1  O  ALA C 131   N  LEU C 106
SHEET    7   C 8 MET C 244  GLY C 249  1  O  LEU C 247   N  VAL C 132
SHEET    8   C 8 VAL C 271  ILE C 276  1  O  GLN C 272   N  ALA C 246
SHEET    1   D 8 GLY D  12  ILE D  16  0
SHEET    2   D 8 ILE D  23  GLY D  28 -1  O  VAL D  27   N  GLY D  12
SHEET    3   D 8 LYS D  59  ALA D  63 -1  O  VAL D  62   N  ARG D  26
SHEET    4   D 8 PRO D  33  LEU D  37  1  N  LEU D  34   O  ILE D  61
SHEET    5   D 8 PHE D 104  HIS D 109  1  O  ALA D 105   N  PRO D  33
SHEET    6   D 8 LEU D 127  LEU D 133  1  O  ALA D 131   N  GLY D 108
SHEET    7   D 8 MET D 244  GLY D 249  1  O  LEU D 245   N  VAL D 132
SHEET    8   D 8 VAL D 271  ILE D 276  1  O  ILE D 276   N  TRP D 248
LINK         N   HIS C   0                NI    NI C 306     1555   1555  1.96
LINK         N   HIS A   0                NI    NI A 306     1555   1555  1.98
LINK         ND1 HIS B   0                NI    NI B 306     1555   1555  2.08
LINK         N   HIS B   0                NI    NI B 306     1555   1555  2.10
LINK         ND1 HIS A   0                NI    NI A 306     1555   1555  2.10
LINK         N   GLY B  -1                NI    NI B 306     1555   1555  2.11
LINK         ND1 HIS C   0                NI    NI C 306     1555   1555  2.17
LINK         N   GLY A  -1                NI    NI A 306     1555   1555  2.19
LINK        NI    NI B 306                 O   HOH B1264     1555   1555  2.20
LINK        NI    NI B 306                 O   HOH B1263     1555   1555  2.25
LINK        NI    NI C 306                 O   HOH C1261     1555   1555  2.38
LINK        NI    NI A 306                 O   HOH A1262     1555   1555  2.68
LINK         N   GLY C  -1                NI    NI C 306     1555   1555  2.78
CISPEP   1 PHE A   40    PRO A   41          0        -2.67
CISPEP   2 ALA A  163    PRO A  164          0         5.54
CISPEP   3 PHE B   40    PRO B   41          0        -1.56
CISPEP   4 ALA B  163    PRO B  164          0         9.92
CISPEP   5 PHE C   40    PRO C   41          0        -0.65
CISPEP   6 ALA C  163    PRO C  164          0         6.08
CISPEP   7 PHE D   40    PRO D   41          0         2.45
CISPEP   8 ALA D  163    PRO D  164          0         5.06
SITE     1 AC1  9 ASP A 110  ARG A 111  ARG A 114  ILE A 135
SITE     2 AC1  9 HIS A 155  TRP A 156  TYR A 219  HOH A 342
SITE     3 AC1  9 HOH A1180
SITE     1 AC2  5 GLY A  -1  HIS A   0  HOH A1262  HIS B 103
SITE     2 AC2  5 GLY B 125
SITE     1 AC3  9 ASP B 110  ARG B 111  ARG B 114  ILE B 135
SITE     2 AC3  9 HIS B 155  TRP B 156  TYR B 219  HOH B 316
SITE     3 AC3  9 HOH B 486
SITE     1 AC4  5 GLY B  -1  HIS B   0  HOH B1263  HOH B1264
SITE     2 AC4  5 HIS C  80
SITE     1 AC5  9 ASP C 110  ARG C 111  ARG C 114  ILE C 135
SITE     2 AC5  9 HIS C 155  TRP C 156  TYR C 219  HOH C 484
SITE     3 AC5  9 HOH C1232
SITE     1 AC6  6 HIS A 103  GLY A 125  GLY C  -1  HIS C   0
SITE     2 AC6  6 MET C   1  HOH C1261
SITE     1 AC7  9 ASP D 110  ARG D 111  ARG D 114  ILE D 135
SITE     2 AC7  9 HIS D 155  TRP D 156  TYR D 219  HOH D 880
SITE     3 AC7  9 HOH D1207
CRYST1   80.080  122.120  132.460  90.00  90.00  90.00 P 21 21 21   16
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.012488  0.000000  0.000000        0.00000
SCALE2      0.000000  0.008189  0.000000        0.00000
SCALE3      0.000000  0.000000  0.007549        0.00000
TER    2438      PRO A 302
TER    4824      ALA B 301
TER    7225      SER C 299
TER    9590      ALA D 300
MASTER      487    0    7   66   32    0   18    610549    4   37   96
END