longtext: 3T52-pdb

content
HEADER    OXIDOREDUCTASE, HYDRLOASE               26-JUL-11   3T52
TITLE     L29I MUTATION IN AN ARYL ESTERASE FROM PSEUDOMONAS FLUORESCENS LEADS
TITLE    2 TO UNIQUE PEPTIDE FLIP AND INCREASED ACTIVITY
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: ARYLESTERASE;
COMPND   3 CHAIN: A, B, C, D, E, F;
COMPND   4 SYNONYM: ARYL-ESTER HYDROLASE, PFE, BROMOPEROXIDASE;
COMPND   5 EC: 3.1.1.2, 1.-.-.-;
COMPND   6 ENGINEERED: YES;
COMPND   7 MUTATION: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: PSEUDOMONAS FLUORESCENS;
SOURCE   3 ORGANISM_TAXID: 294;
SOURCE   4 STRAIN: SIK WI;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE   7 EXPRESSION_SYSTEM_STRAIN: DH5 ALPHA;
SOURCE   8 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE   9 EXPRESSION_SYSTEM_PLASMID: PL29I
KEYWDS    PEPTIDE FLIP, OXIDOREDUCTASE, HYDRLOASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    R.J.KAZLAUSKAS,T.YIN,V.M.PURPERO
REVDAT   1   01-AUG-12 3T52    0
JRNL        AUTH   T.YIN,R.J.KAZLAUSKAS,V.M.PURPERO
JRNL        TITL   L29I MUTATION IN AN ARYL ESTERASE FROM PSEUDOMONAS
JRNL        TITL 2 FLUORESCENS LEADS TO UNIQUE PEPTIDE FLIP AND INCREASED
JRNL        TITL 3 ACTIVITY
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    2.00 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.5.0109
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.00
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 47.80
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.9
REMARK   3   NUMBER OF REFLECTIONS             : 207522
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.185
REMARK   3   R VALUE            (WORKING SET) : 0.184
REMARK   3   FREE R VALUE                     : 0.211
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000
REMARK   3   FREE R VALUE TEST SET COUNT      : 10433
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.00
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.05
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 14540
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 99.99
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2430
REMARK   3   BIN FREE R VALUE SET COUNT          : 762
REMARK   3   BIN FREE R VALUE                    : 0.2790
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 12719
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 409
REMARK   3   SOLVENT ATOMS            : 1166
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 22.10
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 25.82
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -0.03000
REMARK   3    B22 (A**2) : -0.03000
REMARK   3    B33 (A**2) : 0.05000
REMARK   3    B12 (A**2) : -0.02000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): NULL
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.117
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.077
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 2.781
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.965
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.955
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A): 13786 ; 0.015 ; 0.022
REMARK   3   BOND LENGTHS OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 18676 ; 1.368 ; 1.964
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  1723 ; 5.291 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   649 ;32.455 ;24.114
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  2189 ;13.581 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    77 ;19.499 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  2000 ; 0.104 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A): 10597 ; 0.007 ; 0.021
REMARK   3   GENERAL PLANES OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  8336 ; 0.744 ; 1.500
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2): 13352 ; 1.339 ; 2.000
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  5450 ; 2.214 ; 3.000
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  5279 ; 3.535 ; 4.500
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : BABINET MODEL WITH MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.40
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING
REMARK   3  POSITIONS U VALUES: REFINED INDIVIDUALLY
REMARK   4
REMARK   4 3T52 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 30-JUL-11.
REMARK 100 THE RCSB ID CODE IS RCSB067046.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 10-MAY-08
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 7.5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : ALS
REMARK 200  BEAMLINE                       : 4.2.2
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.98
REMARK 200  MONOCHROMATOR                  : ROSENBAUM-ROCK SI(111) SAGITALLY
REMARK 200                                   FOCUSED MONOCHROMATOR
REMARK 200  OPTICS                         : MIRRORS
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : NOIR-1
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : D*TREK
REMARK 200  DATA SCALING SOFTWARE          : D*TREK
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 207756
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.000
REMARK 200  RESOLUTION RANGE LOW       (A) : 48.330
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 3.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 100.0
REMARK 200  DATA REDUNDANCY                : 5.460
REMARK 200  R MERGE                    (I) : 0.11100
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 6.6000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.00
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.07
REMARK 200  COMPLETENESS FOR SHELL     (%) : 100.0
REMARK 200  DATA REDUNDANCY IN SHELL       : 5.26
REMARK 200  R MERGE FOR SHELL          (I) : 0.42700
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 2.900
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: MOLREP
REMARK 200 STARTING MODEL: PDB ENTRY IVA4
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 72.11
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 4.41
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 1% PEG 400, 1.65M (NH4)2SO4, 0.1M
REMARK 280  HEPES, PH 7.5, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 32
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -Y,X-Y,Z+2/3
REMARK 290       3555   -X+Y,-X,Z+1/3
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -0.500000 -0.866025  0.000000        0.00000
REMARK 290   SMTRY2   2  0.866025 -0.500000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       85.96667
REMARK 290   SMTRY1   3 -0.500000  0.866025  0.000000        0.00000
REMARK 290   SMTRY2   3 -0.866025 -0.500000  0.000000        0.00000
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000       42.98333
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TRIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TRIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 13650 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 27940 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -104.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TRIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TRIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 14650 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 27420 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -86.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D, E, F
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    LEU A  30     -166.62   -119.11
REMARK 500    SER A  94     -124.63     58.08
REMARK 500    TYR A 131       57.02   -142.33
REMARK 500    ASP A 150       85.91   -156.80
REMARK 500    THR A 230      -96.81   -123.16
REMARK 500    LEU B  30     -164.92   -115.83
REMARK 500    GLN B  62       76.57   -119.60
REMARK 500    SER B  94     -123.85     59.41
REMARK 500    LEU B 124      136.27   -171.45
REMARK 500    TYR B 131       58.84   -140.37
REMARK 500    ASP B 150       86.96   -156.67
REMARK 500    THR B 230      -91.99   -123.14
REMARK 500    ASP B 248        7.24     57.97
REMARK 500    TRP C  28      -85.95    -56.15
REMARK 500    ILE C  29       47.17    -91.51
REMARK 500    LEU C  30     -166.64   -120.86
REMARK 500    GLN C  62       74.82   -116.52
REMARK 500    SER C  94     -125.84     57.63
REMARK 500    LEU C 124      134.40   -171.19
REMARK 500    ASP C 150       87.30   -160.39
REMARK 500    THR C 230      -96.64   -125.51
REMARK 500    TRP D  28      -83.31    -56.91
REMARK 500    ILE D  29       47.78    -95.71
REMARK 500    LEU D  30     -164.37   -120.09
REMARK 500    SER D  94     -122.81     58.40
REMARK 500    TYR D 131       58.05   -141.27
REMARK 500    ASP D 150       84.86   -153.54
REMARK 500    THR D 230      -91.48   -123.54
REMARK 500    LEU E  30     -165.06   -121.11
REMARK 500    GLN E  62       78.03   -119.40
REMARK 500    SER E  94     -126.03     57.17
REMARK 500    TYR E 131       56.34   -144.78
REMARK 500    ASP E 150       89.28   -154.64
REMARK 500    THR E 230      -90.85   -123.86
REMARK 500    TRP F  28      -80.51    -61.59
REMARK 500    ILE F  29       45.04    -95.06
REMARK 500    LEU F  30     -165.14   -118.14
REMARK 500    GLN F  62       74.49   -119.11
REMARK 500    SER F  94     -127.19     60.98
REMARK 500    LEU F 124      133.34   -171.72
REMARK 500    ASP F 150       85.12   -162.33
REMARK 500    THR F 230      -94.13   -123.97
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CHIRAL CENTERS
REMARK 500
REMARK 500 UNEXPECTED CONFIGURATION OF THE FOLLOWING CHIRAL
REMARK 500 CENTER(S) USING IMPROPER CA--C--CB--N CHIRALITY
REMARK 500 FOR AMINO ACIDS AND C1'--O4'--N1(N9)--C2' FOR
REMARK 500 NUCLEIC ACIDS OR EQUIVALENT ANGLE
REMARK 500 M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,6X,F5.1,6X,A1,10X,A1,3X,A16)
REMARK 500
REMARK 500  M RES CSSEQI    IMPROPER   EXPECTED   FOUND DETAILS
REMARK 500    ASP A  99        23.4      L          L   OUTSIDE RANGE
REMARK 500    ASP C  99        23.7      L          L   OUTSIDE RANGE
REMARK 500    ASP E  99        23.8      L          L   OUTSIDE RANGE
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH C1028        DISTANCE =  5.04 ANGSTROMS
REMARK 525    HOH D 968        DISTANCE =  5.05 ANGSTROMS
REMARK 525    HOH D1026        DISTANCE =  5.98 ANGSTROMS
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL A 272
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A 273
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL A 274
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL A 275
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEO A 276
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEO A 277
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL A 278
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT A 279
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT A 280
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT A 281
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT A 282
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL A 283
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 272
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 273
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 B 274
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 B 275
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 276
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 277
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 278
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEO B 279
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEO B 280
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEO B 281
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEO B 282
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT B 283
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT B 284
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT B 285
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT B 286
REMARK 800
REMARK 800 SITE_IDENTIFIER: DC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT B 287
REMARK 800
REMARK 800 SITE_IDENTIFIER: DC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 288
REMARK 800
REMARK 800 SITE_IDENTIFIER: DC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 289
REMARK 800
REMARK 800 SITE_IDENTIFIER: DC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL C 272
REMARK 800
REMARK 800 SITE_IDENTIFIER: DC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL C 273
REMARK 800
REMARK 800 SITE_IDENTIFIER: DC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 C 274
REMARK 800
REMARK 800 SITE_IDENTIFIER: DC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 C 275
REMARK 800
REMARK 800 SITE_IDENTIFIER: DC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 C 276
REMARK 800
REMARK 800 SITE_IDENTIFIER: DC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL C 277
REMARK 800
REMARK 800 SITE_IDENTIFIER: EC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL C 278
REMARK 800
REMARK 800 SITE_IDENTIFIER: EC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL C 279
REMARK 800
REMARK 800 SITE_IDENTIFIER: EC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEO C 280
REMARK 800
REMARK 800 SITE_IDENTIFIER: EC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT C 281
REMARK 800
REMARK 800 SITE_IDENTIFIER: EC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT C 282
REMARK 800
REMARK 800 SITE_IDENTIFIER: EC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT C 283
REMARK 800
REMARK 800 SITE_IDENTIFIER: EC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEO C 284
REMARK 800
REMARK 800 SITE_IDENTIFIER: EC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT C 285
REMARK 800
REMARK 800 SITE_IDENTIFIER: EC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT C 286
REMARK 800
REMARK 800 SITE_IDENTIFIER: FC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT C 287
REMARK 800
REMARK 800 SITE_IDENTIFIER: FC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL C 288
REMARK 800
REMARK 800 SITE_IDENTIFIER: FC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL C 289
REMARK 800
REMARK 800 SITE_IDENTIFIER: FC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL D 272
REMARK 800
REMARK 800 SITE_IDENTIFIER: FC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL D 273
REMARK 800
REMARK 800 SITE_IDENTIFIER: FC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 D 274
REMARK 800
REMARK 800 SITE_IDENTIFIER: FC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL D 275
REMARK 800
REMARK 800 SITE_IDENTIFIER: FC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT D 276
REMARK 800
REMARK 800 SITE_IDENTIFIER: FC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL D 277
REMARK 800
REMARK 800 SITE_IDENTIFIER: GC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEO D 278
REMARK 800
REMARK 800 SITE_IDENTIFIER: GC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEO D 279
REMARK 800
REMARK 800 SITE_IDENTIFIER: GC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL D 280
REMARK 800
REMARK 800 SITE_IDENTIFIER: GC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEO D 281
REMARK 800
REMARK 800 SITE_IDENTIFIER: GC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT D 282
REMARK 800
REMARK 800 SITE_IDENTIFIER: GC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT D 283
REMARK 800
REMARK 800 SITE_IDENTIFIER: GC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL D 284
REMARK 800
REMARK 800 SITE_IDENTIFIER: GC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL D 285
REMARK 800
REMARK 800 SITE_IDENTIFIER: GC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL D 286
REMARK 800
REMARK 800 SITE_IDENTIFIER: HC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL E 272
REMARK 800
REMARK 800 SITE_IDENTIFIER: HC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL E 273
REMARK 800
REMARK 800 SITE_IDENTIFIER: HC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 E 274
REMARK 800
REMARK 800 SITE_IDENTIFIER: HC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 E 275
REMARK 800
REMARK 800 SITE_IDENTIFIER: HC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL E 276
REMARK 800
REMARK 800 SITE_IDENTIFIER: HC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL E 277
REMARK 800
REMARK 800 SITE_IDENTIFIER: HC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEO E 278
REMARK 800
REMARK 800 SITE_IDENTIFIER: HC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEO E 279
REMARK 800
REMARK 800 SITE_IDENTIFIER: HC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEO E 280
REMARK 800
REMARK 800 SITE_IDENTIFIER: IC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL E 281
REMARK 800
REMARK 800 SITE_IDENTIFIER: IC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEO E 282
REMARK 800
REMARK 800 SITE_IDENTIFIER: IC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT E 283
REMARK 800
REMARK 800 SITE_IDENTIFIER: IC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT E 284
REMARK 800
REMARK 800 SITE_IDENTIFIER: IC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT E 285
REMARK 800
REMARK 800 SITE_IDENTIFIER: IC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT E 286
REMARK 800
REMARK 800 SITE_IDENTIFIER: IC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT E 287
REMARK 800
REMARK 800 SITE_IDENTIFIER: IC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEO E 288
REMARK 800
REMARK 800 SITE_IDENTIFIER: IC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL E 289
REMARK 800
REMARK 800 SITE_IDENTIFIER: JC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT E 290
REMARK 800
REMARK 800 SITE_IDENTIFIER: JC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL F 272
REMARK 800
REMARK 800 SITE_IDENTIFIER: JC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 F 273
REMARK 800
REMARK 800 SITE_IDENTIFIER: JC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 F 274
REMARK 800
REMARK 800 SITE_IDENTIFIER: JC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 F 275
REMARK 800
REMARK 800 SITE_IDENTIFIER: JC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL F 276
REMARK 800
REMARK 800 SITE_IDENTIFIER: JC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEO F 277
REMARK 800
REMARK 800 SITE_IDENTIFIER: JC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEO F 278
REMARK 800
REMARK 800 SITE_IDENTIFIER: JC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEO F 279
REMARK 800
REMARK 800 SITE_IDENTIFIER: KC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL F 280
REMARK 800
REMARK 800 SITE_IDENTIFIER: KC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT F 281
REMARK 800
REMARK 800 SITE_IDENTIFIER: KC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT F 282
REMARK 800
REMARK 800 SITE_IDENTIFIER: KC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT F 283
REMARK 800
REMARK 800 SITE_IDENTIFIER: KC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL F 284
REMARK 800
REMARK 800 SITE_IDENTIFIER: KC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL F 285
REMARK 800
REMARK 800 SITE_IDENTIFIER: KC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACT F 286
REMARK 800
REMARK 800 SITE_IDENTIFIER: KC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL F 287
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 1VA4   RELATED DB: PDB
REMARK 900 WT ARYL ESTERASE
REMARK 900 RELATED ID: 3HI4   RELATED DB: PDB
REMARK 900 L29P MUTATION
REMARK 900 RELATED ID: 3T4U   RELATED DB: PDB
REMARK 900 L29I RESTING
DBREF  3T52 A    1   271  UNP    P22862   ESTE_PSEFL       2    272
DBREF  3T52 B    1   271  UNP    P22862   ESTE_PSEFL       2    272
DBREF  3T52 C    1   271  UNP    P22862   ESTE_PSEFL       2    272
DBREF  3T52 D    1   271  UNP    P22862   ESTE_PSEFL       2    272
DBREF  3T52 E    1   271  UNP    P22862   ESTE_PSEFL       2    272
DBREF  3T52 F    1   271  UNP    P22862   ESTE_PSEFL       2    272
SEQADV 3T52 ILE A   29  UNP  P22862    LEU    30 ENGINEERED MUTATION
SEQADV 3T52 ILE B   29  UNP  P22862    LEU    30 ENGINEERED MUTATION
SEQADV 3T52 ILE C   29  UNP  P22862    LEU    30 ENGINEERED MUTATION
SEQADV 3T52 ILE D   29  UNP  P22862    LEU    30 ENGINEERED MUTATION
SEQADV 3T52 ILE E   29  UNP  P22862    LEU    30 ENGINEERED MUTATION
SEQADV 3T52 ILE F   29  UNP  P22862    LEU    30 ENGINEERED MUTATION
SEQRES   1 A  271  SER THR PHE VAL ALA LYS ASP GLY THR GLN ILE TYR PHE
SEQRES   2 A  271  LYS ASP TRP GLY SER GLY LYS PRO VAL LEU PHE SER HIS
SEQRES   3 A  271  GLY TRP ILE LEU ASP ALA ASP MET TRP GLU TYR GLN MET
SEQRES   4 A  271  GLU TYR LEU SER SER ARG GLY TYR ARG THR ILE ALA PHE
SEQRES   5 A  271  ASP ARG ARG GLY PHE GLY ARG SER ASP GLN PRO TRP THR
SEQRES   6 A  271  GLY ASN ASP TYR ASP THR PHE ALA ASP ASP ILE ALA GLN
SEQRES   7 A  271  LEU ILE GLU HIS LEU ASP LEU LYS GLU VAL THR LEU VAL
SEQRES   8 A  271  GLY PHE SER MET GLY GLY GLY ASP VAL ALA ARG TYR ILE
SEQRES   9 A  271  ALA ARG HIS GLY SER ALA ARG VAL ALA GLY LEU VAL LEU
SEQRES  10 A  271  LEU GLY ALA VAL THR PRO LEU PHE GLY GLN LYS PRO ASP
SEQRES  11 A  271  TYR PRO GLN GLY VAL PRO LEU ASP VAL PHE ALA ARG PHE
SEQRES  12 A  271  LYS THR GLU LEU LEU LYS ASP ARG ALA GLN PHE ILE SER
SEQRES  13 A  271  ASP PHE ASN ALA PRO PHE TYR GLY ILE ASN LYS GLY GLN
SEQRES  14 A  271  VAL VAL SER GLN GLY VAL GLN THR GLN THR LEU GLN ILE
SEQRES  15 A  271  ALA LEU LEU ALA SER LEU LYS ALA THR VAL ASP CYS VAL
SEQRES  16 A  271  THR ALA PHE ALA GLU THR ASP PHE ARG PRO ASP MET ALA
SEQRES  17 A  271  LYS ILE ASP VAL PRO THR LEU VAL ILE HIS GLY ASP GLY
SEQRES  18 A  271  ASP GLN ILE VAL PRO PHE GLU THR THR GLY LYS VAL ALA
SEQRES  19 A  271  ALA GLU LEU ILE LYS GLY ALA GLU LEU LYS VAL TYR LYS
SEQRES  20 A  271  ASP ALA PRO HIS GLY PHE ALA VAL THR HIS ALA GLN GLN
SEQRES  21 A  271  LEU ASN GLU ASP LEU LEU ALA PHE LEU LYS ARG
SEQRES   1 B  271  SER THR PHE VAL ALA LYS ASP GLY THR GLN ILE TYR PHE
SEQRES   2 B  271  LYS ASP TRP GLY SER GLY LYS PRO VAL LEU PHE SER HIS
SEQRES   3 B  271  GLY TRP ILE LEU ASP ALA ASP MET TRP GLU TYR GLN MET
SEQRES   4 B  271  GLU TYR LEU SER SER ARG GLY TYR ARG THR ILE ALA PHE
SEQRES   5 B  271  ASP ARG ARG GLY PHE GLY ARG SER ASP GLN PRO TRP THR
SEQRES   6 B  271  GLY ASN ASP TYR ASP THR PHE ALA ASP ASP ILE ALA GLN
SEQRES   7 B  271  LEU ILE GLU HIS LEU ASP LEU LYS GLU VAL THR LEU VAL
SEQRES   8 B  271  GLY PHE SER MET GLY GLY GLY ASP VAL ALA ARG TYR ILE
SEQRES   9 B  271  ALA ARG HIS GLY SER ALA ARG VAL ALA GLY LEU VAL LEU
SEQRES  10 B  271  LEU GLY ALA VAL THR PRO LEU PHE GLY GLN LYS PRO ASP
SEQRES  11 B  271  TYR PRO GLN GLY VAL PRO LEU ASP VAL PHE ALA ARG PHE
SEQRES  12 B  271  LYS THR GLU LEU LEU LYS ASP ARG ALA GLN PHE ILE SER
SEQRES  13 B  271  ASP PHE ASN ALA PRO PHE TYR GLY ILE ASN LYS GLY GLN
SEQRES  14 B  271  VAL VAL SER GLN GLY VAL GLN THR GLN THR LEU GLN ILE
SEQRES  15 B  271  ALA LEU LEU ALA SER LEU LYS ALA THR VAL ASP CYS VAL
SEQRES  16 B  271  THR ALA PHE ALA GLU THR ASP PHE ARG PRO ASP MET ALA
SEQRES  17 B  271  LYS ILE ASP VAL PRO THR LEU VAL ILE HIS GLY ASP GLY
SEQRES  18 B  271  ASP GLN ILE VAL PRO PHE GLU THR THR GLY LYS VAL ALA
SEQRES  19 B  271  ALA GLU LEU ILE LYS GLY ALA GLU LEU LYS VAL TYR LYS
SEQRES  20 B  271  ASP ALA PRO HIS GLY PHE ALA VAL THR HIS ALA GLN GLN
SEQRES  21 B  271  LEU ASN GLU ASP LEU LEU ALA PHE LEU LYS ARG
SEQRES   1 C  271  SER THR PHE VAL ALA LYS ASP GLY THR GLN ILE TYR PHE
SEQRES   2 C  271  LYS ASP TRP GLY SER GLY LYS PRO VAL LEU PHE SER HIS
SEQRES   3 C  271  GLY TRP ILE LEU ASP ALA ASP MET TRP GLU TYR GLN MET
SEQRES   4 C  271  GLU TYR LEU SER SER ARG GLY TYR ARG THR ILE ALA PHE
SEQRES   5 C  271  ASP ARG ARG GLY PHE GLY ARG SER ASP GLN PRO TRP THR
SEQRES   6 C  271  GLY ASN ASP TYR ASP THR PHE ALA ASP ASP ILE ALA GLN
SEQRES   7 C  271  LEU ILE GLU HIS LEU ASP LEU LYS GLU VAL THR LEU VAL
SEQRES   8 C  271  GLY PHE SER MET GLY GLY GLY ASP VAL ALA ARG TYR ILE
SEQRES   9 C  271  ALA ARG HIS GLY SER ALA ARG VAL ALA GLY LEU VAL LEU
SEQRES  10 C  271  LEU GLY ALA VAL THR PRO LEU PHE GLY GLN LYS PRO ASP
SEQRES  11 C  271  TYR PRO GLN GLY VAL PRO LEU ASP VAL PHE ALA ARG PHE
SEQRES  12 C  271  LYS THR GLU LEU LEU LYS ASP ARG ALA GLN PHE ILE SER
SEQRES  13 C  271  ASP PHE ASN ALA PRO PHE TYR GLY ILE ASN LYS GLY GLN
SEQRES  14 C  271  VAL VAL SER GLN GLY VAL GLN THR GLN THR LEU GLN ILE
SEQRES  15 C  271  ALA LEU LEU ALA SER LEU LYS ALA THR VAL ASP CYS VAL
SEQRES  16 C  271  THR ALA PHE ALA GLU THR ASP PHE ARG PRO ASP MET ALA
SEQRES  17 C  271  LYS ILE ASP VAL PRO THR LEU VAL ILE HIS GLY ASP GLY
SEQRES  18 C  271  ASP GLN ILE VAL PRO PHE GLU THR THR GLY LYS VAL ALA
SEQRES  19 C  271  ALA GLU LEU ILE LYS GLY ALA GLU LEU LYS VAL TYR LYS
SEQRES  20 C  271  ASP ALA PRO HIS GLY PHE ALA VAL THR HIS ALA GLN GLN
SEQRES  21 C  271  LEU ASN GLU ASP LEU LEU ALA PHE LEU LYS ARG
SEQRES   1 D  271  SER THR PHE VAL ALA LYS ASP GLY THR GLN ILE TYR PHE
SEQRES   2 D  271  LYS ASP TRP GLY SER GLY LYS PRO VAL LEU PHE SER HIS
SEQRES   3 D  271  GLY TRP ILE LEU ASP ALA ASP MET TRP GLU TYR GLN MET
SEQRES   4 D  271  GLU TYR LEU SER SER ARG GLY TYR ARG THR ILE ALA PHE
SEQRES   5 D  271  ASP ARG ARG GLY PHE GLY ARG SER ASP GLN PRO TRP THR
SEQRES   6 D  271  GLY ASN ASP TYR ASP THR PHE ALA ASP ASP ILE ALA GLN
SEQRES   7 D  271  LEU ILE GLU HIS LEU ASP LEU LYS GLU VAL THR LEU VAL
SEQRES   8 D  271  GLY PHE SER MET GLY GLY GLY ASP VAL ALA ARG TYR ILE
SEQRES   9 D  271  ALA ARG HIS GLY SER ALA ARG VAL ALA GLY LEU VAL LEU
SEQRES  10 D  271  LEU GLY ALA VAL THR PRO LEU PHE GLY GLN LYS PRO ASP
SEQRES  11 D  271  TYR PRO GLN GLY VAL PRO LEU ASP VAL PHE ALA ARG PHE
SEQRES  12 D  271  LYS THR GLU LEU LEU LYS ASP ARG ALA GLN PHE ILE SER
SEQRES  13 D  271  ASP PHE ASN ALA PRO PHE TYR GLY ILE ASN LYS GLY GLN
SEQRES  14 D  271  VAL VAL SER GLN GLY VAL GLN THR GLN THR LEU GLN ILE
SEQRES  15 D  271  ALA LEU LEU ALA SER LEU LYS ALA THR VAL ASP CYS VAL
SEQRES  16 D  271  THR ALA PHE ALA GLU THR ASP PHE ARG PRO ASP MET ALA
SEQRES  17 D  271  LYS ILE ASP VAL PRO THR LEU VAL ILE HIS GLY ASP GLY
SEQRES  18 D  271  ASP GLN ILE VAL PRO PHE GLU THR THR GLY LYS VAL ALA
SEQRES  19 D  271  ALA GLU LEU ILE LYS GLY ALA GLU LEU LYS VAL TYR LYS
SEQRES  20 D  271  ASP ALA PRO HIS GLY PHE ALA VAL THR HIS ALA GLN GLN
SEQRES  21 D  271  LEU ASN GLU ASP LEU LEU ALA PHE LEU LYS ARG
SEQRES   1 E  271  SER THR PHE VAL ALA LYS ASP GLY THR GLN ILE TYR PHE
SEQRES   2 E  271  LYS ASP TRP GLY SER GLY LYS PRO VAL LEU PHE SER HIS
SEQRES   3 E  271  GLY TRP ILE LEU ASP ALA ASP MET TRP GLU TYR GLN MET
SEQRES   4 E  271  GLU TYR LEU SER SER ARG GLY TYR ARG THR ILE ALA PHE
SEQRES   5 E  271  ASP ARG ARG GLY PHE GLY ARG SER ASP GLN PRO TRP THR
SEQRES   6 E  271  GLY ASN ASP TYR ASP THR PHE ALA ASP ASP ILE ALA GLN
SEQRES   7 E  271  LEU ILE GLU HIS LEU ASP LEU LYS GLU VAL THR LEU VAL
SEQRES   8 E  271  GLY PHE SER MET GLY GLY GLY ASP VAL ALA ARG TYR ILE
SEQRES   9 E  271  ALA ARG HIS GLY SER ALA ARG VAL ALA GLY LEU VAL LEU
SEQRES  10 E  271  LEU GLY ALA VAL THR PRO LEU PHE GLY GLN LYS PRO ASP
SEQRES  11 E  271  TYR PRO GLN GLY VAL PRO LEU ASP VAL PHE ALA ARG PHE
SEQRES  12 E  271  LYS THR GLU LEU LEU LYS ASP ARG ALA GLN PHE ILE SER
SEQRES  13 E  271  ASP PHE ASN ALA PRO PHE TYR GLY ILE ASN LYS GLY GLN
SEQRES  14 E  271  VAL VAL SER GLN GLY VAL GLN THR GLN THR LEU GLN ILE
SEQRES  15 E  271  ALA LEU LEU ALA SER LEU LYS ALA THR VAL ASP CYS VAL
SEQRES  16 E  271  THR ALA PHE ALA GLU THR ASP PHE ARG PRO ASP MET ALA
SEQRES  17 E  271  LYS ILE ASP VAL PRO THR LEU VAL ILE HIS GLY ASP GLY
SEQRES  18 E  271  ASP GLN ILE VAL PRO PHE GLU THR THR GLY LYS VAL ALA
SEQRES  19 E  271  ALA GLU LEU ILE LYS GLY ALA GLU LEU LYS VAL TYR LYS
SEQRES  20 E  271  ASP ALA PRO HIS GLY PHE ALA VAL THR HIS ALA GLN GLN
SEQRES  21 E  271  LEU ASN GLU ASP LEU LEU ALA PHE LEU LYS ARG
SEQRES   1 F  271  SER THR PHE VAL ALA LYS ASP GLY THR GLN ILE TYR PHE
SEQRES   2 F  271  LYS ASP TRP GLY SER GLY LYS PRO VAL LEU PHE SER HIS
SEQRES   3 F  271  GLY TRP ILE LEU ASP ALA ASP MET TRP GLU TYR GLN MET
SEQRES   4 F  271  GLU TYR LEU SER SER ARG GLY TYR ARG THR ILE ALA PHE
SEQRES   5 F  271  ASP ARG ARG GLY PHE GLY ARG SER ASP GLN PRO TRP THR
SEQRES   6 F  271  GLY ASN ASP TYR ASP THR PHE ALA ASP ASP ILE ALA GLN
SEQRES   7 F  271  LEU ILE GLU HIS LEU ASP LEU LYS GLU VAL THR LEU VAL
SEQRES   8 F  271  GLY PHE SER MET GLY GLY GLY ASP VAL ALA ARG TYR ILE
SEQRES   9 F  271  ALA ARG HIS GLY SER ALA ARG VAL ALA GLY LEU VAL LEU
SEQRES  10 F  271  LEU GLY ALA VAL THR PRO LEU PHE GLY GLN LYS PRO ASP
SEQRES  11 F  271  TYR PRO GLN GLY VAL PRO LEU ASP VAL PHE ALA ARG PHE
SEQRES  12 F  271  LYS THR GLU LEU LEU LYS ASP ARG ALA GLN PHE ILE SER
SEQRES  13 F  271  ASP PHE ASN ALA PRO PHE TYR GLY ILE ASN LYS GLY GLN
SEQRES  14 F  271  VAL VAL SER GLN GLY VAL GLN THR GLN THR LEU GLN ILE
SEQRES  15 F  271  ALA LEU LEU ALA SER LEU LYS ALA THR VAL ASP CYS VAL
SEQRES  16 F  271  THR ALA PHE ALA GLU THR ASP PHE ARG PRO ASP MET ALA
SEQRES  17 F  271  LYS ILE ASP VAL PRO THR LEU VAL ILE HIS GLY ASP GLY
SEQRES  18 F  271  ASP GLN ILE VAL PRO PHE GLU THR THR GLY LYS VAL ALA
SEQRES  19 F  271  ALA GLU LEU ILE LYS GLY ALA GLU LEU LYS VAL TYR LYS
SEQRES  20 F  271  ASP ALA PRO HIS GLY PHE ALA VAL THR HIS ALA GLN GLN
SEQRES  21 F  271  LEU ASN GLU ASP LEU LEU ALA PHE LEU LYS ARG
HET    GOL  A 272       6
HET    SO4  A 273       5
HET     CL  A 274       1
HET     CL  A 275       1
HET    PEO  A 276       2
HET    PEO  A 277       2
HET    GOL  A 278       6
HET    ACT  A 279       4
HET    ACT  A 280       4
HET    ACT  A 281       4
HET    ACT  A 282       4
HET    GOL  A 283       6
HET    GOL  B 272       6
HET    GOL  B 273       6
HET    SO4  B 274       5
HET    SO4  B 275       5
HET     CL  B 276       1
HET    GOL  B 277       6
HET    GOL  B 278       6
HET    PEO  B 279       2
HET    PEO  B 280       2
HET    PEO  B 281       2
HET    PEO  B 282       2
HET    ACT  B 283       4
HET    ACT  B 284       4
HET    ACT  B 285       4
HET    ACT  B 286       8
HET    ACT  B 287       4
HET    GOL  B 288       6
HET    GOL  B 289       6
HET    GOL  C 272       6
HET    GOL  C 273       6
HET    SO4  C 274       5
HET    SO4  C 275       5
HET    SO4  C 276       5
HET     CL  C 277       1
HET     CL  C 278       1
HET    GOL  C 279       6
HET    PEO  C 280       2
HET    ACT  C 281       4
HET    ACT  C 282       4
HET    ACT  C 283       4
HET    PEO  C 284       2
HET    ACT  C 285       4
HET    ACT  C 286       4
HET    ACT  C 287       4
HET    GOL  C 288       6
HET    GOL  C 289       6
HET    GOL  D 272       6
HET    GOL  D 273       6
HET    SO4  D 274       5
HET     CL  D 275       1
HET    ACT  D 276       4
HET    GOL  D 277       6
HET    PEO  D 278       2
HET    PEO  D 279       2
HET    GOL  D 280      12
HET    PEO  D 281       2
HET    ACT  D 282       4
HET    ACT  D 283       4
HET    GOL  D 284       6
HET    GOL  D 285       6
HET    GOL  D 286       6
HET    GOL  E 272       6
HET    GOL  E 273       6
HET    SO4  E 274       5
HET    SO4  E 275       5
HET     CL  E 276       1
HET    GOL  E 277       6
HET    PEO  E 278       2
HET    PEO  E 279       2
HET    PEO  E 280       2
HET    GOL  E 281       6
HET    PEO  E 282       2
HET    ACT  E 283       4
HET    ACT  E 284       4
HET    ACT  E 285       4
HET    ACT  E 286       8
HET    ACT  E 287       4
HET    PEO  E 288       2
HET    GOL  E 289       6
HET    ACT  E 290       4
HET    GOL  F 272       6
HET    SO4  F 273       5
HET    SO4  F 274       5
HET    SO4  F 275       5
HET    GOL  F 276       6
HET    PEO  F 277       2
HET    PEO  F 278       2
HET    PEO  F 279       2
HET    GOL  F 280       6
HET    ACT  F 281       4
HET    ACT  F 282       4
HET    ACT  F 283       4
HET    GOL  F 284       6
HET    GOL  F 285      12
HET    ACT  F 286       4
HET    GOL  F 287       6
HETNAM     GOL GLYCEROL
HETNAM     SO4 SULFATE ION
HETNAM      CL CHLORIDE ION
HETNAM     PEO HYDROGEN PEROXIDE
HETNAM     ACT ACETATE ION
HETSYN     GOL GLYCERIN; PROPANE-1,2,3-TRIOL
FORMUL   7  GOL    32(C3 H8 O3)
FORMUL   8  SO4    12(O4 S 2-)
FORMUL   9   CL    7(CL 1-)
FORMUL  11  PEO    19(H2 O2)
FORMUL  14  ACT    28(C2 H3 O2 1-)
FORMUL  05  HOH   *1166(H2 O)
HELIX    1   1 ASP A   31  MET A   34  5                                   4
HELIX    2   2 TRP A   35  SER A   44  1                                  10
HELIX    3   3 ASP A   68  LEU A   83  1                                  16
HELIX    4   4 MET A   95  GLY A  108  1                                  14
HELIX    5   5 PRO A  136  GLY A  164  1                                  29
HELIX    6   6 ILE A  165  GLY A  168  5                                   4
HELIX    7   7 SER A  172  ALA A  186  1                                  15
HELIX    8   8 SER A  187  THR A  201  1                                  15
HELIX    9   9 PHE A  203  ILE A  210  1                                   8
HELIX   10  10 PRO A  226  THR A  229  5                                   4
HELIX   11  11 THR A  230  ILE A  238  1                                   9
HELIX   12  12 GLY A  252  HIS A  257  1                                   6
HELIX   13  13 HIS A  257  ARG A  271  1                                  15
HELIX   14  14 ASP B   31  MET B   34  5                                   4
HELIX   15  15 TRP B   35  SER B   44  1                                  10
HELIX   16  16 ASP B   68  LEU B   83  1                                  16
HELIX   17  17 MET B   95  GLY B  108  1                                  14
HELIX   18  18 PRO B  136  TYR B  163  1                                  28
HELIX   19  19 GLY B  164  GLY B  168  5                                   5
HELIX   20  20 SER B  172  ALA B  186  1                                  15
HELIX   21  21 SER B  187  THR B  201  1                                  15
HELIX   22  22 PHE B  203  ILE B  210  1                                   8
HELIX   23  23 PRO B  226  THR B  229  5                                   4
HELIX   24  24 THR B  230  ILE B  238  1                                   9
HELIX   25  25 GLY B  252  HIS B  257  1                                   6
HELIX   26  26 HIS B  257  ARG B  271  1                                  15
HELIX   27  27 ASP C   31  MET C   34  5                                   4
HELIX   28  28 TRP C   35  SER C   44  1                                  10
HELIX   29  29 ASP C   68  LEU C   83  1                                  16
HELIX   30  30 MET C   95  GLY C  108  1                                  14
HELIX   31  31 PRO C  136  GLY C  164  1                                  29
HELIX   32  32 ILE C  165  GLY C  168  5                                   4
HELIX   33  33 SER C  172  ALA C  186  1                                  15
HELIX   34  34 SER C  187  THR C  201  1                                  15
HELIX   35  35 PHE C  203  LYS C  209  1                                   7
HELIX   36  36 PRO C  226  THR C  229  5                                   4
HELIX   37  37 THR C  230  ILE C  238  1                                   9
HELIX   38  38 GLY C  252  HIS C  257  1                                   6
HELIX   39  39 HIS C  257  LYS C  270  1                                  14
HELIX   40  40 ASP D   31  MET D   34  5                                   4
HELIX   41  41 TRP D   35  SER D   44  1                                  10
HELIX   42  42 ASP D   68  ASP D   84  1                                  17
HELIX   43  43 MET D   95  GLY D  108  1                                  14
HELIX   44  44 PRO D  136  GLY D  164  1                                  29
HELIX   45  45 ILE D  165  GLY D  168  5                                   4
HELIX   46  46 SER D  172  ALA D  186  1                                  15
HELIX   47  47 SER D  187  THR D  201  1                                  15
HELIX   48  48 PHE D  203  ILE D  210  1                                   8
HELIX   49  49 PRO D  226  THR D  229  5                                   4
HELIX   50  50 THR D  230  ILE D  238  1                                   9
HELIX   51  51 GLY D  252  HIS D  257  1                                   6
HELIX   52  52 HIS D  257  ARG D  271  1                                  15
HELIX   53  53 ASP E   31  MET E   34  5                                   4
HELIX   54  54 TRP E   35  SER E   44  1                                  10
HELIX   55  55 ASP E   68  LEU E   83  1                                  16
HELIX   56  56 MET E   95  GLY E  108  1                                  14
HELIX   57  57 PRO E  136  GLY E  164  1                                  29
HELIX   58  58 ILE E  165  GLY E  168  5                                   4
HELIX   59  59 SER E  172  ALA E  186  1                                  15
HELIX   60  60 SER E  187  THR E  201  1                                  15
HELIX   61  61 PHE E  203  ILE E  210  1                                   8
HELIX   62  62 PRO E  226  THR E  229  5                                   4
HELIX   63  63 THR E  230  ILE E  238  1                                   9
HELIX   64  64 GLY E  252  HIS E  257  1                                   6
HELIX   65  65 HIS E  257  ARG E  271  1                                  15
HELIX   66  66 ASP F   31  MET F   34  5                                   4
HELIX   67  67 TRP F   35  SER F   44  1                                  10
HELIX   68  68 ASP F   68  ASP F   84  1                                  17
HELIX   69  69 MET F   95  GLY F  108  1                                  14
HELIX   70  70 PRO F  136  GLY F  164  1                                  29
HELIX   71  71 ILE F  165  GLY F  168  5                                   4
HELIX   72  72 SER F  172  ALA F  186  1                                  15
HELIX   73  73 SER F  187  THR F  201  1                                  15
HELIX   74  74 PHE F  203  LYS F  209  1                                   7
HELIX   75  75 PRO F  226  THR F  229  5                                   4
HELIX   76  76 THR F  230  ILE F  238  1                                   9
HELIX   77  77 GLY F  252  HIS F  257  1                                   6
HELIX   78  78 HIS F  257  LYS F  270  1                                  14
SHEET    1   A 8 THR A   2  VAL A   4  0
SHEET    2   A 8 GLN A  10  TRP A  16 -1  O  ILE A  11   N  PHE A   3
SHEET    3   A 8 ARG A  48  PHE A  52 -1  O  THR A  49   N  TRP A  16
SHEET    4   A 8 PRO A  21  SER A  25  1  N  PHE A  24   O  ILE A  50
SHEET    5   A 8 VAL A  88  PHE A  93  1  O  VAL A  91   N  SER A  25
SHEET    6   A 8 VAL A 112  LEU A 118  1  O  LEU A 118   N  GLY A  92
SHEET    7   A 8 THR A 214  GLY A 219  1  O  ILE A 217   N  LEU A 117
SHEET    8   A 8 GLU A 242  TYR A 246  1  O  GLU A 242   N  THR A 214
SHEET    1   B 8 THR B   2  VAL B   4  0
SHEET    2   B 8 GLN B  10  TRP B  16 -1  O  ILE B  11   N  PHE B   3
SHEET    3   B 8 ARG B  48  PHE B  52 -1  O  THR B  49   N  TRP B  16
SHEET    4   B 8 PRO B  21  SER B  25  1  N  PHE B  24   O  ILE B  50
SHEET    5   B 8 VAL B  88  PHE B  93  1  O  VAL B  91   N  SER B  25
SHEET    6   B 8 VAL B 112  LEU B 118  1  O  LEU B 118   N  GLY B  92
SHEET    7   B 8 THR B 214  GLY B 219  1  O  ILE B 217   N  LEU B 117
SHEET    8   B 8 GLU B 242  TYR B 246  1  O  GLU B 242   N  VAL B 216
SHEET    1   C 8 THR C   2  VAL C   4  0
SHEET    2   C 8 GLN C  10  TRP C  16 -1  O  ILE C  11   N  PHE C   3
SHEET    3   C 8 ARG C  48  PHE C  52 -1  O  THR C  49   N  TRP C  16
SHEET    4   C 8 PRO C  21  SER C  25  1  N  PHE C  24   O  ILE C  50
SHEET    5   C 8 VAL C  88  PHE C  93  1  O  VAL C  91   N  LEU C  23
SHEET    6   C 8 VAL C 112  LEU C 118  1  O  LEU C 118   N  GLY C  92
SHEET    7   C 8 THR C 214  GLY C 219  1  O  ILE C 217   N  LEU C 117
SHEET    8   C 8 GLU C 242  TYR C 246  1  O  GLU C 242   N  VAL C 216
SHEET    1   D 8 THR D   2  VAL D   4  0
SHEET    2   D 8 GLN D  10  TRP D  16 -1  O  ILE D  11   N  PHE D   3
SHEET    3   D 8 ARG D  48  PHE D  52 -1  O  THR D  49   N  TRP D  16
SHEET    4   D 8 PRO D  21  SER D  25  1  N  PHE D  24   O  ILE D  50
SHEET    5   D 8 VAL D  88  PHE D  93  1  O  VAL D  91   N  SER D  25
SHEET    6   D 8 VAL D 112  LEU D 118  1  O  LEU D 118   N  GLY D  92
SHEET    7   D 8 THR D 214  GLY D 219  1  O  ILE D 217   N  LEU D 117
SHEET    8   D 8 GLU D 242  TYR D 246  1  O  GLU D 242   N  VAL D 216
SHEET    1   E 8 THR E   2  VAL E   4  0
SHEET    2   E 8 GLN E  10  TRP E  16 -1  O  ILE E  11   N  PHE E   3
SHEET    3   E 8 ARG E  48  PHE E  52 -1  O  THR E  49   N  TRP E  16
SHEET    4   E 8 PRO E  21  SER E  25  1  N  PHE E  24   O  ILE E  50
SHEET    5   E 8 VAL E  88  PHE E  93  1  O  VAL E  91   N  SER E  25
SHEET    6   E 8 VAL E 112  LEU E 118  1  O  LEU E 118   N  GLY E  92
SHEET    7   E 8 THR E 214  GLY E 219  1  O  ILE E 217   N  LEU E 117
SHEET    8   E 8 GLU E 242  TYR E 246  1  O  GLU E 242   N  VAL E 216
SHEET    1   F 8 THR F   2  VAL F   4  0
SHEET    2   F 8 GLN F  10  GLY F  17 -1  O  ILE F  11   N  PHE F   3
SHEET    3   F 8 ARG F  48  PHE F  52 -1  O  THR F  49   N  TRP F  16
SHEET    4   F 8 PRO F  21  SER F  25  1  N  PHE F  24   O  ILE F  50
SHEET    5   F 8 VAL F  88  PHE F  93  1  O  VAL F  91   N  SER F  25
SHEET    6   F 8 VAL F 112  LEU F 118  1  O  LEU F 118   N  GLY F  92
SHEET    7   F 8 THR F 214  GLY F 219  1  O  ILE F 217   N  LEU F 117
SHEET    8   F 8 GLU F 242  TYR F 246  1  O  GLU F 242   N  VAL F 216
CISPEP   1 THR A  122    PRO A  123          0         6.11
CISPEP   2 THR B  122    PRO B  123          0         3.12
CISPEP   3 THR C  122    PRO C  123          0         3.60
CISPEP   4 THR D  122    PRO D  123          0         3.59
CISPEP   5 THR E  122    PRO E  123          0         3.44
CISPEP   6 THR F  122    PRO F  123          0         4.77
SITE     1 AC1  7 SER A   1  TYR A  12  LYS A  14  ASP A  15
SITE     2 AC1  7 HOH A 540  ASP C  61  GLN C  62
SITE     1 AC2  1 ARG A 106
SITE     1 AC3  2 LYS A 247  GLN A 260
SITE     1 AC4  1 HOH A 871
SITE     1 AC5  3 VAL A 212  PRO A 213  HOH A 980
SITE     1 AC6  2 LYS A 128  HOH A 723
SITE     1 AC7  5 LEU A 137  ALA A 141  LYS A 144  THR A 196
SITE     2 AC7  5 GLU A 200
SITE     1 AC8  3 SER A 156  ASN A 159  GLN A 173
SITE     1 AC9  6 ASP A   7  PRO A  63  TRP A  64  THR A  65
SITE     2 AC9  6 HOH A 389  HOH A1076
SITE     1 BC1  9 GLY A  27  TRP A  28  ILE A  29  LEU A  30
SITE     2 BC1  9 PHE A  93  SER A  94  PHE A 162  HIS A 251
SITE     3 BC1  9 ACT A 282
SITE     1 BC2  7 TRP A  28  SER A  94  MET A  95  VAL A 121
SITE     2 BC2  7 PHE A 125  ILE A 224  ACT A 281
SITE     1 BC3  3 GLN A 223  ILE A 224  HOH A1073
SITE     1 BC4  5 LEU B 137  ALA B 141  LYS B 144  GLU B 200
SITE     2 BC4  5 PEO B 281
SITE     1 BC5  8 ASP A  61  GLN A  62  SER B   1  TYR B  12
SITE     2 BC5  8 PHE B  13  LYS B  14  ASP B  15  HOH B 311
SITE     1 BC6  1 ARG B 106
SITE     1 BC7  4 VAL B 245  TYR B 246  LYS B 247  GLN B 260
SITE     1 BC8  1 GLY B 240
SITE     1 BC9  4 GLN B 223  ILE B 224  ACT B 286  ACT B 287
SITE     1 CC1  6 SER B   1  THR B   2  LYS B 167  GLY B 168
SITE     2 CC1  6 HOH B 303  HOH B 311
SITE     1 CC2  3 ARG B 102  ASP B 202  HOH B 909
SITE     1 CC3  2 GLY B  17  SER B  18
SITE     1 CC4  3 ASP B 138  ALA B 141  GOL B 272
SITE     1 CC5  3 HOH A 292  HOH B 297  HOH B 875
SITE     1 CC6  7 GLY B  27  TRP B  28  PHE B  93  SER B  94
SITE     2 CC6  7 PHE B 162  HIS B 251  ACT B 284
SITE     1 CC7  8 TRP B  28  SER B  94  MET B  95  VAL B 121
SITE     2 CC7  8 PHE B 125  PHE B 198  ILE B 224  ACT B 283
SITE     1 CC8  6 ASP B   7  PRO B  63  TRP B  64  THR B  65
SITE     2 CC8  6 HOH B 359  HOH B1096
SITE     1 CC9  4 ILE B 224  GOL B 277  ACT B 287  HOH B 797
SITE     1 DC1  6 TRP B  28  PHE B 143  PHE B 158  ILE B 224
SITE     2 DC1  6 GOL B 277  ACT B 286
SITE     1 DC2  2 TRP B  64  SER C  18
SITE     1 DC3  2 ARG B  45  HOH B1146
SITE     1 DC4  7 ASP B  61  GLN B  62  SER C   1  TYR C  12
SITE     2 DC4  7 LYS C  14  ASP C  15  HOH C 297
SITE     1 DC5  4 LEU C 137  ALA C 141  LYS C 144  GLU C 200
SITE     1 DC6  5 VAL C 245  TYR C 246  LYS C 247  GLN C 260
SITE     2 DC6  5 HOH C 736
SITE     1 DC7  5 HIS B 107  GLN C 173  HOH C 310  HOH C 372
SITE     2 DC7  5 HOH C 712
SITE     1 DC8  2 ARG C 106  ACT C 281
SITE     1 DC9  1 GLY C 240
SITE     1 EC1  1 ARG C  45
SITE     1 EC2  6 PHE C 143  GLN C 223  ILE C 224  PRO C 226
SITE     2 EC2  6 ACT C 286  ACT C 287
SITE     1 EC3  4 ARG C 102  ASP C 202  GOL C 289  HOH C 669
SITE     1 EC4  5 THR C  71  ASP C  74  SO4 C 276  HOH C 847
SITE     2 EC4  5 HOH C1072
SITE     1 EC5 10 GLY C  27  TRP C  28  ILE C  29  LEU C  30
SITE     2 EC5 10 PHE C  93  SER C  94  PHE C 158  PHE C 162
SITE     3 EC5 10 HIS C 251  ACT C 283
SITE     1 EC6  9 TRP C  28  SER C  94  MET C  95  VAL C 121
SITE     2 EC6  9 PHE C 125  PHE C 198  ILE C 224  HIS C 251
SITE     3 EC6  9 ACT C 282
SITE     1 EC7  2 GLN C 259  GLU C 263
SITE     1 EC8  7 ASP C   7  PRO C  63  TRP C  64  THR C  65
SITE     2 EC8  7 HOH C 337  HOH C1094  HOH C1095
SITE     1 EC9  4 ILE C 224  GOL C 279  ACT C 287  HOH C 895
SITE     1 FC1  5 TRP C  28  PHE C 143  PHE C 158  GOL C 279
SITE     2 FC1  5 ACT C 286
SITE     1 FC2  4 ASN A 166  SER C  18  GLY C  19  HOH C 870
SITE     1 FC3  3 LYS C 128  ASP C 202  PEO C 280
SITE     1 FC4  5 LEU D 137  ALA D 141  LYS D 144  GLU D 200
SITE     2 FC4  5 HOH D 628
SITE     1 FC5  7 SER D   1  TYR D  12  LYS D  14  ASP D  15
SITE     2 FC5  7 HOH D 401  ASP E  61  GLN E  62
SITE     1 FC6  1 ARG D 106
SITE     1 FC7  1 HOH D 573
SITE     1 FC8  4 VAL D 245  LYS D 247  GLN D 260  HOH D 374
SITE     1 FC9  7 PHE D 125  VAL D 139  GLN D 223  ILE D 224
SITE     2 FC9  7 GOL D 284  HOH D 359  HOH D1080
SITE     1 GC1  1 ASP D 202
SITE     1 GC2  2 THR D 214  GLY D 240
SITE     1 GC3  4 LYS D 239  GLY D 240  HOH D 500  HOH D 657
SITE     1 GC4  2 GLU D  40  ARG D  45
SITE     1 GC5  9 GLY D  27  TRP D  28  ILE D  29  PHE D  93
SITE     2 GC5  9 SER D  94  PHE D 158  PHE D 162  HIS D 251
SITE     3 GC5  9 ACT D 283
SITE     1 GC6 10 TRP D  28  SER D  94  MET D  95  VAL D 121
SITE     2 GC6 10 PHE D 125  PHE D 198  ILE D 224  HIS D 251
SITE     3 GC6 10 ACT D 282  GOL D 284
SITE     1 GC7  9 TRP D  28  PHE D 140  PHE D 143  PHE D 158
SITE     2 GC7  9 PHE D 198  ILE D 224  GOL D 277  ACT D 283
SITE     3 GC7  9 HOH D1080
SITE     1 GC8  5 ALA D 235  GLU D 236  ALA D 241  HOH D 423
SITE     2 GC8  5 HOH D 887
SITE     1 GC9  5 GLN D 127  LYS D 128  PRO D 129  PRO D 132
SITE     2 GC9  5 HOH D 779
SITE     1 HC1  7 SER E   1  TYR E  12  LYS E  14  ASP E  15
SITE     2 HC1  7 HOH E 859  ASP F  61  GLN F  62
SITE     1 HC2  5 LEU E 137  ALA E 141  LYS E 144  GLU E 200
SITE     2 HC2  5 HOH E 814
SITE     1 HC3  1 ARG E 106
SITE     1 HC4  3 LYS E 239  GLY E 240  HOH E 794
SITE     1 HC5  2 LYS E 247  GLN E 260
SITE     1 HC6  6 PHE E 143  GLN E 223  ILE E 224  PRO E 226
SITE     2 HC6  6 ACT E 286  ACT E 287
SITE     1 HC7  5 GLN E 173  GLY E 174  THR E 177  SER F 156
SITE     2 HC7  5 LEU F 180
SITE     1 HC8  2 SER E  18  GLY E  19
SITE     1 HC9  2 THR E  65  GLY E  66
SITE     1 IC1 10 LEU E  30  MET E  34  TYR E 163  GLN E 178
SITE     2 IC1 10 THR E 179  ILE E 182  VAL E 255  HOH E 326
SITE     3 IC1 10 HOH E 929  HOH E1125
SITE     1 IC2  4 TYR D  37  VAL D 175  LYS E 149  HOH E1115
SITE     1 IC3  8 GLY E  27  TRP E  28  LEU E  30  PHE E  93
SITE     2 IC3  8 SER E  94  PHE E 162  HIS E 251  ACT E 284
SITE     1 IC4  8 TRP E  28  SER E  94  MET E  95  VAL E 121
SITE     2 IC4  8 PHE E 125  PHE E 198  ILE E 224  ACT E 283
SITE     1 IC5  6 ASP E   7  PRO E  63  TRP E  64  THR E  65
SITE     2 IC5  6 HOH E 315  HOH E 335
SITE     1 IC6  4 ILE E 224  GOL E 277  ACT E 287  ACT E 290
SITE     1 IC7  7 TRP E  28  PHE E 140  PHE E 143  PHE E 158
SITE     2 IC7  7 ILE E 224  GOL E 277  ACT E 286
SITE     1 IC8  2 THR E 201  ASP E 202
SITE     1 IC9  5 LYS E   6  ASP E  74  GLU E  81  HIS E 107
SITE     2 IC9  5 HOH E1150
SITE     1 JC1  4 PHE E 154  PHE E 158  ACT E 286  HOH E1123
SITE     1 JC2  7 ASP D  61  GLN D  62  SER F   1  TYR F  12
SITE     2 JC2  7 LYS F  14  ASP F  15  HOH F 322
SITE     1 JC3  5 VAL F 245  TYR F 246  LYS F 247  GLN F 260
SITE     2 JC3  5 HOH F 548
SITE     1 JC4  5 ILE F 238  LYS F 239  GLY F 240  HOH F 535
SITE     2 JC4  5 HOH F 646
SITE     1 JC5  1 ARG F 106
SITE     1 JC6  5 PHE F 143  GLN F 223  ILE F 224  PRO F 226
SITE     2 JC6  5 ACT F 286
SITE     1 JC7  2 LYS F 144  GLU F 200
SITE     1 JC8  1 TRP F  64
SITE     1 JC9  3 SER F 156  ASN F 159  GLN F 173
SITE     1 KC1  3 PHE F 143  ACT F 286  HOH F 818
SITE     1 KC2  8 TRP F  28  SER F  94  MET F  95  VAL F 121
SITE     2 KC2  8 PHE F 125  PHE F 198  ILE F 224  ACT F 282
SITE     1 KC3  6 GLY F  27  TRP F  28  SER F  94  PHE F 162
SITE     2 KC3  6 HIS F 251  ACT F 281
SITE     1 KC4  6 ASP F   7  PRO F  63  TRP F  64  THR F  65
SITE     2 KC4  6 HOH F 320  HOH F1092
SITE     1 KC5  7 LEU D 148  TYR F  37  GLU F  40  ALA F 258
SITE     2 KC5  7 ASN F 262  HOH F 619  HOH F 620
SITE     1 KC6 12 LEU F  30  ASP F  31  MET F  34  TYR F 163
SITE     2 KC6 12 GLN F 178  THR F 179  ILE F 182  VAL F 255
SITE     3 KC6 12 HOH F 325  HOH F 436  HOH F 810  HOH F 828
SITE     1 KC7  7 TRP F  28  PHE F 140  PHE F 143  PHE F 158
SITE     2 KC7  7 ILE F 224  GOL F 276  GOL F 280
SITE     1 KC8  1 ARG F  45
CRYST1  146.020  146.020  128.950  90.00  90.00 120.00 P 32         18
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.006848  0.003954  0.000000        0.00000
SCALE2      0.000000  0.007908  0.000000        0.00000
SCALE3      0.000000  0.000000  0.007755        0.00000
TER    2181      ARG A 271
TER    4379      ARG B 271
TER    6553      ARG C 271
TER    8713      ARG D 271
TER   10911      ARG E 271
TER   13106      ARG F 271
MASTER      737    0   98   78   48    0  155    614294    6  422  126
END