longtext: 3U1T-pdb

content
HEADER    HYDROLASE                               30-SEP-11   3U1T
TITLE     HALOALKANE DEHALOGENASE, DMMA, OF MARINE MICROBIAL ORIGIN
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: DMMA HALOALKANE DEHALOGENASE;
COMPND   3 CHAIN: A, B;
COMPND   4 FRAGMENT: DMMASHORT;
COMPND   5 EC: 3.8.1.5;
COMPND   6 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: UNIDENTIFIED;
SOURCE   3 ORGANISM_TAXID: 32644;
SOURCE   4 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   5 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE   6 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);
SOURCE   7 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE   8 EXPRESSION_SYSTEM_PLASMID: PET-24B
KEYWDS    ALPHA/BETA-HYDROLASE, HALOALKANE DEHALOGENASE, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    J.J GEHRET,J.L.SMITH
REVDAT   1   28-DEC-11 3U1T    0
JRNL        AUTH   J.J.GEHRET,L.GU,T.W.GEDERS,W.C.BROWN,L.GERWICK,W.H.GERWICK,
JRNL        AUTH 2 D.H.SHERMAN,J.L.SMITH
JRNL        TITL   STRUCTURE AND ACTIVITY OF DMMA, A MARINE HALOALKANE
JRNL        TITL 2 DEHALOGENASE.
JRNL        REF    PROTEIN SCI.                               2011
JRNL        REFN                   ESSN 1469-896X
JRNL        PMID   22124946
JRNL        DOI    10.1002/PRO.2009
REMARK   2
REMARK   2 RESOLUTION.    2.20 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.5.0102
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.20
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 86.39
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.6
REMARK   3   NUMBER OF REFLECTIONS             : 33173
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.141
REMARK   3   R VALUE            (WORKING SET) : 0.139
REMARK   3   FREE R VALUE                     : 0.177
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000
REMARK   3   FREE R VALUE TEST SET COUNT      : 1746
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.20
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.25
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 2408
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 97.69
REMARK   3   BIN R VALUE           (WORKING SET) : 0.1820
REMARK   3   BIN FREE R VALUE SET COUNT          : 130
REMARK   3   BIN FREE R VALUE                    : 0.2490
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 4628
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 18
REMARK   3   SOLVENT ATOMS            : 497
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 24.70
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : 1.10000
REMARK   3    B22 (A**2) : 1.10000
REMARK   3    B33 (A**2) : -1.66000
REMARK   3    B12 (A**2) : 0.55000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.200
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.157
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.105
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 9.240
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.971
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.951
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  4801 ; 0.009 ; 0.022
REMARK   3   BOND LENGTHS OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES):  6556 ; 1.195 ; 1.973
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):   603 ; 4.974 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   215 ;31.819 ;23.395
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):   729 ;13.124 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    35 ;16.544 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):   705 ; 0.075 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  3777 ; 0.005 ; 0.022
REMARK   3   GENERAL PLANES OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  3003 ; 0.362 ; 1.500
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  4848 ; 0.718 ; 2.000
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  1798 ; 1.479 ; 3.000
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  1704 ; 2.369 ; 4.500
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 10
REMARK   3
REMARK   3   TLS GROUP : 1
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A    44        A   113
REMARK   3    ORIGIN FOR THE GROUP (A):  46.6973  23.6756  50.2337
REMARK   3    T TENSOR
REMARK   3      T11:   0.0670 T22:   0.1005
REMARK   3      T33:   0.0240 T12:  -0.0087
REMARK   3      T13:   0.0054 T23:  -0.0148
REMARK   3    L TENSOR
REMARK   3      L11:   1.4868 L22:   0.5360
REMARK   3      L33:   1.1181 L12:   0.3750
REMARK   3      L13:  -0.3495 L23:  -0.5319
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0018 S12:   0.1047 S13:  -0.0084
REMARK   3      S21:  -0.0696 S22:  -0.0127 S23:   0.0334
REMARK   3      S31:   0.0493 S32:  -0.0194 S33:   0.0145
REMARK   3
REMARK   3   TLS GROUP : 2
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A   114        A   177
REMARK   3    ORIGIN FOR THE GROUP (A):  46.9589  33.7999  59.9725
REMARK   3    T TENSOR
REMARK   3      T11:   0.0806 T22:   0.0760
REMARK   3      T33:   0.0641 T12:  -0.0111
REMARK   3      T13:   0.0115 T23:   0.0054
REMARK   3    L TENSOR
REMARK   3      L11:   0.9853 L22:   0.7046
REMARK   3      L33:   1.1528 L12:   0.2497
REMARK   3      L13:  -0.2853 L23:   0.1640
REMARK   3    S TENSOR
REMARK   3      S11:   0.0185 S12:   0.0450 S13:   0.0871
REMARK   3      S21:   0.0606 S22:  -0.0568 S23:   0.0122
REMARK   3      S31:  -0.2264 S32:   0.0197 S33:   0.0383
REMARK   3
REMARK   3   TLS GROUP : 3
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A   178        A   256
REMARK   3    ORIGIN FOR THE GROUP (A):  63.5302  22.6696  64.0506
REMARK   3    T TENSOR
REMARK   3      T11:   0.0347 T22:   0.1314
REMARK   3      T33:   0.0488 T12:  -0.0282
REMARK   3      T13:   0.0150 T23:   0.0239
REMARK   3    L TENSOR
REMARK   3      L11:   0.7738 L22:   0.6435
REMARK   3      L33:   1.4357 L12:  -0.0607
REMARK   3      L13:   0.1786 L23:   0.1995
REMARK   3    S TENSOR
REMARK   3      S11:   0.0217 S12:   0.0537 S13:  -0.0530
REMARK   3      S21:   0.0567 S22:  -0.0529 S23:  -0.0577
REMARK   3      S31:  -0.0290 S32:   0.1202 S33:   0.0312
REMARK   3
REMARK   3   TLS GROUP : 4
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A   257        A   273
REMARK   3    ORIGIN FOR THE GROUP (A):  48.9805  38.3874  70.2081
REMARK   3    T TENSOR
REMARK   3      T11:   0.1938 T22:   0.0422
REMARK   3      T33:   0.0779 T12:  -0.0246
REMARK   3      T13:  -0.0013 T23:  -0.0396
REMARK   3    L TENSOR
REMARK   3      L11:  15.2278 L22:   2.2439
REMARK   3      L33:   2.0057 L12:   0.2964
REMARK   3      L13:  -2.7779 L23:   1.3074
REMARK   3    S TENSOR
REMARK   3      S11:   0.1226 S12:  -0.1837 S13:   0.3421
REMARK   3      S21:   0.2074 S22:  -0.1326 S23:   0.0428
REMARK   3      S31:  -0.2200 S32:  -0.0686 S33:   0.0099
REMARK   3
REMARK   3   TLS GROUP : 5
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A   274        A   341
REMARK   3    ORIGIN FOR THE GROUP (A):  38.7606  21.5180  68.3103
REMARK   3    T TENSOR
REMARK   3      T11:   0.0603 T22:   0.0876
REMARK   3      T33:   0.0378 T12:  -0.0187
REMARK   3      T13:   0.0289 T23:  -0.0230
REMARK   3    L TENSOR
REMARK   3      L11:   1.4247 L22:   0.9816
REMARK   3      L33:   0.8556 L12:   0.3010
REMARK   3      L13:  -0.0075 L23:  -0.1163
REMARK   3    S TENSOR
REMARK   3      S11:   0.0574 S12:  -0.0433 S13:   0.0631
REMARK   3      S21:   0.0819 S22:  -0.0648 S23:   0.0636
REMARK   3      S31:   0.0037 S32:  -0.0594 S33:   0.0074
REMARK   3
REMARK   3   TLS GROUP : 6
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   B    44        B   118
REMARK   3    ORIGIN FOR THE GROUP (A):  23.9821   1.3443  86.7254
REMARK   3    T TENSOR
REMARK   3      T11:   0.0667 T22:   0.1125
REMARK   3      T33:   0.0518 T12:  -0.0487
REMARK   3      T13:   0.0466 T23:  -0.0616
REMARK   3    L TENSOR
REMARK   3      L11:   0.3806 L22:   1.5435
REMARK   3      L33:   1.3494 L12:  -0.1713
REMARK   3      L13:  -0.1389 L23:  -0.6606
REMARK   3    S TENSOR
REMARK   3      S11:   0.0351 S12:  -0.1000 S13:   0.0199
REMARK   3      S21:   0.2490 S22:  -0.0280 S23:   0.1529
REMARK   3      S31:  -0.0265 S32:  -0.0838 S33:  -0.0071
REMARK   3
REMARK   3   TLS GROUP : 7
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   B   119        B   176
REMARK   3    ORIGIN FOR THE GROUP (A):  14.9855   4.5110  77.4791
REMARK   3    T TENSOR
REMARK   3      T11:   0.0328 T22:   0.1528
REMARK   3      T33:   0.1410 T12:  -0.0361
REMARK   3      T13:   0.0194 T23:  -0.0648
REMARK   3    L TENSOR
REMARK   3      L11:   0.5018 L22:   1.1225
REMARK   3      L33:   1.4130 L12:  -0.1122
REMARK   3      L13:  -0.0885 L23:  -0.3363
REMARK   3    S TENSOR
REMARK   3      S11:   0.0782 S12:  -0.0821 S13:  -0.0203
REMARK   3      S21:  -0.0374 S22:  -0.0276 S23:   0.3102
REMARK   3      S31:  -0.0515 S32:  -0.2581 S33:  -0.0506
REMARK   3
REMARK   3   TLS GROUP : 8
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   B   177        B   196
REMARK   3    ORIGIN FOR THE GROUP (A):  21.1927 -13.4015  62.1826
REMARK   3    T TENSOR
REMARK   3      T11:   0.4719 T22:   0.3442
REMARK   3      T33:   0.1630 T12:   0.0174
REMARK   3      T13:  -0.0082 T23:  -0.1097
REMARK   3    L TENSOR
REMARK   3      L11:  17.7836 L22:   4.2399
REMARK   3      L33:  19.2650 L12:  -6.6739
REMARK   3      L13:  -0.0033 L23:  -5.7763
REMARK   3    S TENSOR
REMARK   3      S11:   1.0609 S12:   0.8466 S13:   0.7152
REMARK   3      S21:  -0.3391 S22:  -0.9366 S23:  -0.2451
REMARK   3      S31:  -0.3869 S32:   1.6550 S33:  -0.1243
REMARK   3
REMARK   3   TLS GROUP : 9
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   B   197        B   251
REMARK   3    ORIGIN FOR THE GROUP (A):  27.7442 -14.2107  77.7459
REMARK   3    T TENSOR
REMARK   3      T11:   0.1207 T22:   0.0904
REMARK   3      T33:   0.0572 T12:  -0.0411
REMARK   3      T13:  -0.0016 T23:  -0.0399
REMARK   3    L TENSOR
REMARK   3      L11:   0.1288 L22:   2.4588
REMARK   3      L33:   0.8922 L12:  -0.0664
REMARK   3      L13:  -0.2973 L23:   0.1510
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0230 S12:  -0.0190 S13:  -0.0446
REMARK   3      S21:  -0.0585 S22:  -0.0529 S23:   0.0209
REMARK   3      S31:   0.2113 S32:   0.0023 S33:   0.0759
REMARK   3
REMARK   3   TLS GROUP : 10
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   B   252        B   341
REMARK   3    ORIGIN FOR THE GROUP (A):  23.0585   7.5968  68.5527
REMARK   3    T TENSOR
REMARK   3      T11:   0.0438 T22:   0.0976
REMARK   3      T33:   0.0383 T12:   0.0031
REMARK   3      T13:  -0.0098 T23:  -0.0523
REMARK   3    L TENSOR
REMARK   3      L11:   1.1022 L22:   2.3050
REMARK   3      L33:   0.9864 L12:   0.4081
REMARK   3      L13:  -0.2505 L23:  -0.3365
REMARK   3    S TENSOR
REMARK   3      S11:   0.0932 S12:   0.0596 S13:   0.0381
REMARK   3      S21:  -0.2272 S22:  -0.0986 S23:   0.1901
REMARK   3      S31:  -0.0080 S32:  -0.0652 S33:   0.0053
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.40
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING
REMARK   3  POSITIONS
REMARK   4
REMARK   4 3U1T COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 03-OCT-11.
REMARK 100 THE RCSB ID CODE IS RCSB068198.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 28-NOV-07
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 7.0
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : APS
REMARK 200  BEAMLINE                       : 23-ID-D
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.97939
REMARK 200  MONOCHROMATOR                  : DOUBLE CRYSTAL MONOCHROMATOR
REMARK 200  OPTICS                         : MIRRORS
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : MARMOSAIC 300 MM CCD
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 35045
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.200
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 0.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 100.0
REMARK 200  DATA REDUNDANCY                : 5.800
REMARK 200  R MERGE                    (I) : 0.12200
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 8.3000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.20
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.28
REMARK 200  COMPLETENESS FOR SHELL     (%) : 99.9
REMARK 200  DATA REDUNDANCY IN SHELL       : 5.20
REMARK 200  R MERGE FOR SHELL          (I) : 0.54900
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: SAD
REMARK 200 SOFTWARE USED: SOLVE
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 51.29
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.53
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 2.2 M SODIUM MALONATE PH 7.0, 5%
REMARK 280  GLYCEROL, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 62
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -Y,X-Y,Z+2/3
REMARK 290       3555   -X+Y,-X,Z+1/3
REMARK 290       4555   -X,-Y,Z
REMARK 290       5555   Y,-X+Y,Z+2/3
REMARK 290       6555   X-Y,X,Z+1/3
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -0.500000 -0.866025  0.000000        0.00000
REMARK 290   SMTRY2   2  0.866025 -0.500000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       81.33600
REMARK 290   SMTRY1   3 -0.500000  0.866025  0.000000        0.00000
REMARK 290   SMTRY2   3 -0.866025 -0.500000  0.000000        0.00000
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000       40.66800
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   4  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   5  0.500000  0.866025  0.000000        0.00000
REMARK 290   SMTRY2   5 -0.866025  0.500000  0.000000        0.00000
REMARK 290   SMTRY3   5  0.000000  0.000000  1.000000       81.33600
REMARK 290   SMTRY1   6  0.500000 -0.866025  0.000000        0.00000
REMARK 290   SMTRY2   6  0.866025  0.500000  0.000000        0.00000
REMARK 290   SMTRY3   6  0.000000  0.000000  1.000000       40.66800
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 3
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 7540 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 39540 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -84.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350   BIOMT1   2 -1.000000  0.000000  0.000000       99.78400
REMARK 350   BIOMT2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 350   BIOMT3   2  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MSE A    41
REMARK 465     ALA A    42
REMARK 465     SER A    43
REMARK 465     LEU A   342
REMARK 465     GLU A   343
REMARK 465     HIS A   344
REMARK 465     HIS A   345
REMARK 465     HIS A   346
REMARK 465     HIS A   347
REMARK 465     HIS A   348
REMARK 465     HIS A   349
REMARK 465     MSE B    41
REMARK 465     ALA B    42
REMARK 465     LEU B   342
REMARK 465     GLU B   343
REMARK 465     HIS B   344
REMARK 465     HIS B   345
REMARK 465     HIS B   346
REMARK 465     HIS B   347
REMARK 465     HIS B   348
REMARK 465     HIS B   349
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    PRO A  48       40.57    -85.22
REMARK 500    PRO A  79       51.01   -108.83
REMARK 500    THR A  80     -160.25   -100.22
REMARK 500    LYS A 112       67.86   -117.20
REMARK 500    ASP A 144     -127.94     57.73
REMARK 500    GLN A 186      -63.29   -100.33
REMARK 500    ASP A 198      -49.50     76.83
REMARK 500    THR A 213      -58.19   -126.04
REMARK 500    ALA A 288      -71.60   -135.05
REMARK 500    THR A 314      -81.11   -115.79
REMARK 500    HIS A 321       57.74   -141.22
REMARK 500    LYS A 337       55.61     38.46
REMARK 500    PRO B  79       48.95   -107.91
REMARK 500    THR B  80     -159.09   -100.52
REMARK 500    LYS B 112       67.17   -118.71
REMARK 500    ASP B 144     -130.08     54.35
REMARK 500    ASP B 198      -50.16     77.23
REMARK 500    THR B 213      -53.49   -128.42
REMARK 500    ALA B 288      -72.58   -132.63
REMARK 500    THR B 314      -82.16   -112.74
REMARK 500    HIS B 321       53.49   -140.71
REMARK 500    LYS B 337       59.11     35.55
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH A 455        DISTANCE =  5.62 ANGSTROMS
REMARK 525    HOH A 456        DISTANCE =  6.95 ANGSTROMS
REMARK 525    HOH A 493        DISTANCE =  7.31 ANGSTROMS
REMARK 525    HOH A 610        DISTANCE =  5.60 ANGSTROMS
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL A 1
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 1
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL A 350
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MLI A 351
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MLI B 350
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 351
REMARK 999
REMARK 999 SEQUENCE
REMARK 999 SQUENCE WAS ORIGINALLY ANNOTATED AS CURN FROM CYANOBACTERIA LYNGBYA
REMARK 999 MAJUSCULA. IT IS NOW THOUGHT THAT CURN GENETIC MATERIAL IS FROM A
REMARK 999 BACTERIA THAT WAS GROWING IN ASSOCIATION WITH L. MAJUSCULA AT THE
REMARK 999 TIME OF COSMID PREPARATION. CURN HAS BEEN RENAMED DMMA.
DBREF  3U1T A   44   341  UNP    Q6DND9   Q6DND9_9CYAN    44    341
DBREF  3U1T B   44   341  UNP    Q6DND9   Q6DND9_9CYAN    44    341
SEQADV 3U1T MSE A   41  UNP  Q6DND9              EXPRESSION TAG
SEQADV 3U1T ALA A   42  UNP  Q6DND9              EXPRESSION TAG
SEQADV 3U1T SER A   43  UNP  Q6DND9              EXPRESSION TAG
SEQADV 3U1T LEU A  342  UNP  Q6DND9              EXPRESSION TAG
SEQADV 3U1T GLU A  343  UNP  Q6DND9              EXPRESSION TAG
SEQADV 3U1T HIS A  344  UNP  Q6DND9              EXPRESSION TAG
SEQADV 3U1T HIS A  345  UNP  Q6DND9              EXPRESSION TAG
SEQADV 3U1T HIS A  346  UNP  Q6DND9              EXPRESSION TAG
SEQADV 3U1T HIS A  347  UNP  Q6DND9              EXPRESSION TAG
SEQADV 3U1T HIS A  348  UNP  Q6DND9              EXPRESSION TAG
SEQADV 3U1T HIS A  349  UNP  Q6DND9              EXPRESSION TAG
SEQADV 3U1T MSE B   41  UNP  Q6DND9              EXPRESSION TAG
SEQADV 3U1T ALA B   42  UNP  Q6DND9              EXPRESSION TAG
SEQADV 3U1T SER B   43  UNP  Q6DND9              EXPRESSION TAG
SEQADV 3U1T LEU B  342  UNP  Q6DND9              EXPRESSION TAG
SEQADV 3U1T GLU B  343  UNP  Q6DND9              EXPRESSION TAG
SEQADV 3U1T HIS B  344  UNP  Q6DND9              EXPRESSION TAG
SEQADV 3U1T HIS B  345  UNP  Q6DND9              EXPRESSION TAG
SEQADV 3U1T HIS B  346  UNP  Q6DND9              EXPRESSION TAG
SEQADV 3U1T HIS B  347  UNP  Q6DND9              EXPRESSION TAG
SEQADV 3U1T HIS B  348  UNP  Q6DND9              EXPRESSION TAG
SEQADV 3U1T HIS B  349  UNP  Q6DND9              EXPRESSION TAG
SEQRES   1 A  309  MSE ALA SER SER SER GLU PHE PRO PHE ALA LYS ARG THR
SEQRES   2 A  309  VAL GLU VAL GLU GLY ALA THR ILE ALA TYR VAL ASP GLU
SEQRES   3 A  309  GLY SER GLY GLN PRO VAL LEU PHE LEU HIS GLY ASN PRO
SEQRES   4 A  309  THR SER SER TYR LEU TRP ARG ASN ILE ILE PRO TYR VAL
SEQRES   5 A  309  VAL ALA ALA GLY TYR ARG ALA VAL ALA PRO ASP LEU ILE
SEQRES   6 A  309  GLY MSE GLY ASP SER ALA LYS PRO ASP ILE GLU TYR ARG
SEQRES   7 A  309  LEU GLN ASP HIS VAL ALA TYR MSE ASP GLY PHE ILE ASP
SEQRES   8 A  309  ALA LEU GLY LEU ASP ASP MSE VAL LEU VAL ILE HIS ASP
SEQRES   9 A  309  TRP GLY SER VAL ILE GLY MSE ARG HIS ALA ARG LEU ASN
SEQRES  10 A  309  PRO ASP ARG VAL ALA ALA VAL ALA PHE MSE GLU ALA LEU
SEQRES  11 A  309  VAL PRO PRO ALA LEU PRO MSE PRO SER TYR GLU ALA MSE
SEQRES  12 A  309  GLY PRO GLN LEU GLY PRO LEU PHE ARG ASP LEU ARG THR
SEQRES  13 A  309  ALA ASP VAL GLY GLU LYS MSE VAL LEU ASP GLY ASN PHE
SEQRES  14 A  309  PHE VAL GLU THR ILE LEU PRO GLU MSE GLY VAL VAL ARG
SEQRES  15 A  309  SER LEU SER GLU ALA GLU MSE ALA ALA TYR ARG ALA PRO
SEQRES  16 A  309  PHE PRO THR ARG GLN SER ARG LEU PRO THR LEU GLN TRP
SEQRES  17 A  309  PRO ARG GLU VAL PRO ILE GLY GLY GLU PRO ALA PHE ALA
SEQRES  18 A  309  GLU ALA GLU VAL LEU LYS ASN GLY GLU TRP LEU MSE ALA
SEQRES  19 A  309  SER PRO ILE PRO LYS LEU LEU PHE HIS ALA GLU PRO GLY
SEQRES  20 A  309  ALA LEU ALA PRO LYS PRO VAL VAL ASP TYR LEU SER GLU
SEQRES  21 A  309  ASN VAL PRO ASN LEU GLU VAL ARG PHE VAL GLY ALA GLY
SEQRES  22 A  309  THR HIS PHE LEU GLN GLU ASP HIS PRO HIS LEU ILE GLY
SEQRES  23 A  309  GLN GLY ILE ALA ASP TRP LEU ARG ARG ASN LYS PRO HIS
SEQRES  24 A  309  ALA SER LEU GLU HIS HIS HIS HIS HIS HIS
SEQRES   1 B  309  MSE ALA SER SER SER GLU PHE PRO PHE ALA LYS ARG THR
SEQRES   2 B  309  VAL GLU VAL GLU GLY ALA THR ILE ALA TYR VAL ASP GLU
SEQRES   3 B  309  GLY SER GLY GLN PRO VAL LEU PHE LEU HIS GLY ASN PRO
SEQRES   4 B  309  THR SER SER TYR LEU TRP ARG ASN ILE ILE PRO TYR VAL
SEQRES   5 B  309  VAL ALA ALA GLY TYR ARG ALA VAL ALA PRO ASP LEU ILE
SEQRES   6 B  309  GLY MSE GLY ASP SER ALA LYS PRO ASP ILE GLU TYR ARG
SEQRES   7 B  309  LEU GLN ASP HIS VAL ALA TYR MSE ASP GLY PHE ILE ASP
SEQRES   8 B  309  ALA LEU GLY LEU ASP ASP MSE VAL LEU VAL ILE HIS ASP
SEQRES   9 B  309  TRP GLY SER VAL ILE GLY MSE ARG HIS ALA ARG LEU ASN
SEQRES  10 B  309  PRO ASP ARG VAL ALA ALA VAL ALA PHE MSE GLU ALA LEU
SEQRES  11 B  309  VAL PRO PRO ALA LEU PRO MSE PRO SER TYR GLU ALA MSE
SEQRES  12 B  309  GLY PRO GLN LEU GLY PRO LEU PHE ARG ASP LEU ARG THR
SEQRES  13 B  309  ALA ASP VAL GLY GLU LYS MSE VAL LEU ASP GLY ASN PHE
SEQRES  14 B  309  PHE VAL GLU THR ILE LEU PRO GLU MSE GLY VAL VAL ARG
SEQRES  15 B  309  SER LEU SER GLU ALA GLU MSE ALA ALA TYR ARG ALA PRO
SEQRES  16 B  309  PHE PRO THR ARG GLN SER ARG LEU PRO THR LEU GLN TRP
SEQRES  17 B  309  PRO ARG GLU VAL PRO ILE GLY GLY GLU PRO ALA PHE ALA
SEQRES  18 B  309  GLU ALA GLU VAL LEU LYS ASN GLY GLU TRP LEU MSE ALA
SEQRES  19 B  309  SER PRO ILE PRO LYS LEU LEU PHE HIS ALA GLU PRO GLY
SEQRES  20 B  309  ALA LEU ALA PRO LYS PRO VAL VAL ASP TYR LEU SER GLU
SEQRES  21 B  309  ASN VAL PRO ASN LEU GLU VAL ARG PHE VAL GLY ALA GLY
SEQRES  22 B  309  THR HIS PHE LEU GLN GLU ASP HIS PRO HIS LEU ILE GLY
SEQRES  23 B  309  GLN GLY ILE ALA ASP TRP LEU ARG ARG ASN LYS PRO HIS
SEQRES  24 B  309  ALA SER LEU GLU HIS HIS HIS HIS HIS HIS
MODRES 3U1T MSE A  107  MET  SELENOMETHIONINE
MODRES 3U1T MSE A  126  MET  SELENOMETHIONINE
MODRES 3U1T MSE A  138  MET  SELENOMETHIONINE
MODRES 3U1T MSE A  151  MET  SELENOMETHIONINE
MODRES 3U1T MSE A  167  MET  SELENOMETHIONINE
MODRES 3U1T MSE A  177  MET  SELENOMETHIONINE
MODRES 3U1T MSE A  183  MET  SELENOMETHIONINE
MODRES 3U1T MSE A  203  MET  SELENOMETHIONINE
MODRES 3U1T MSE A  218  MET  SELENOMETHIONINE
MODRES 3U1T MSE A  229  MET  SELENOMETHIONINE
MODRES 3U1T MSE A  273  MET  SELENOMETHIONINE
MODRES 3U1T MSE B  107  MET  SELENOMETHIONINE
MODRES 3U1T MSE B  126  MET  SELENOMETHIONINE
MODRES 3U1T MSE B  138  MET  SELENOMETHIONINE
MODRES 3U1T MSE B  151  MET  SELENOMETHIONINE
MODRES 3U1T MSE B  167  MET  SELENOMETHIONINE
MODRES 3U1T MSE B  177  MET  SELENOMETHIONINE
MODRES 3U1T MSE B  183  MET  SELENOMETHIONINE
MODRES 3U1T MSE B  203  MET  SELENOMETHIONINE
MODRES 3U1T MSE B  218  MET  SELENOMETHIONINE
MODRES 3U1T MSE B  229  MET  SELENOMETHIONINE
MODRES 3U1T MSE B  273  MET  SELENOMETHIONINE
HET    MSE  A 107       8
HET    MSE  A 126       8
HET    MSE  A 138       8
HET    MSE  A 151       8
HET    MSE  A 167       8
HET    MSE  A 177       8
HET    MSE  A 183       8
HET    MSE  A 203       8
HET    MSE  A 218       8
HET    MSE  A 229       8
HET    MSE  A 273       8
HET    MSE  B 107       8
HET    MSE  B 126       8
HET    MSE  B 138       8
HET    MSE  B 151       8
HET    MSE  B 167       8
HET    MSE  B 177       8
HET    MSE  B 183       8
HET    MSE  B 203       8
HET    MSE  B 218       8
HET    MSE  B 229       8
HET    MSE  B 273       8
HET     CL  A   1       1
HET     CL  A 350       1
HET    MLI  A 351       7
HET     CL  B   1       1
HET     CL  B 351       1
HET    MLI  B 350       7
HETNAM     MSE SELENOMETHIONINE
HETNAM      CL CHLORIDE ION
HETNAM     MLI MALONATE ION
FORMUL   1  MSE    22(C5 H11 N O2 SE)
FORMUL   3   CL    4(CL 1-)
FORMUL   5  MLI    2(C3 H2 O4 2-)
FORMUL   9  HOH   *497(H2 O)
HELIX    1   1 SER A   81  ARG A   86  5                                   6
HELIX    2   2 ILE A   88  ALA A   95  1                                   8
HELIX    3   3 ARG A  118  GLY A  134  1                                  17
HELIX    4   4 ASP A  144  ASN A  157  1                                  14
HELIX    5   5 TYR A  180  ALA A  182  5                                   3
HELIX    6   6 MSE A  183  ARG A  195  1                                  13
HELIX    7   7 ASP A  198  LEU A  205  1                                   8
HELIX    8   8 ASN A  208  THR A  213  1                                   6
HELIX    9   9 THR A  213  MSE A  218  1                                   6
HELIX   10  10 SER A  225  ALA A  234  1                                  10
HELIX   11  11 ARG A  239  SER A  241  5                                   3
HELIX   12  12 ARG A  242  VAL A  252  1                                  11
HELIX   13  13 PRO A  258  SER A  275  1                                  18
HELIX   14  14 PRO A  291  VAL A  302  1                                  12
HELIX   15  15 PHE A  316  HIS A  321  1                                   6
HELIX   16  16 HIS A  321  LYS A  337  1                                  17
HELIX   17  17 SER B   81  ARG B   86  5                                   6
HELIX   18  18 ILE B   88  ALA B   95  1                                   8
HELIX   19  19 ARG B  118  GLY B  134  1                                  17
HELIX   20  20 TRP B  145  ASN B  157  1                                  13
HELIX   21  21 TYR B  180  ALA B  182  5                                   3
HELIX   22  22 MSE B  183  ARG B  195  1                                  13
HELIX   23  23 ASP B  198  LEU B  205  1                                   8
HELIX   24  24 ASN B  208  THR B  213  1                                   6
HELIX   25  25 THR B  213  MSE B  218  1                                   6
HELIX   26  26 SER B  225  ALA B  234  1                                  10
HELIX   27  27 ARG B  239  SER B  241  5                                   3
HELIX   28  28 ARG B  242  VAL B  252  1                                  11
HELIX   29  29 PRO B  258  SER B  275  1                                  18
HELIX   30  30 PRO B  291  VAL B  302  1                                  12
HELIX   31  31 PHE B  316  HIS B  321  1                                   6
HELIX   32  32 HIS B  321  LYS B  337  1                                  17
SHEET    1   A 8 ARG A  52  VAL A  56  0
SHEET    2   A 8 ALA A  59  GLY A  67 -1  O  ALA A  59   N  VAL A  56
SHEET    3   A 8 ARG A  98  PRO A 102 -1  O  ALA A  99   N  GLU A  66
SHEET    4   A 8 PRO A  71  LEU A  75  1  N  VAL A  72   O  ARG A  98
SHEET    5   A 8 MSE A 138  HIS A 143  1  O  VAL A 139   N  LEU A  73
SHEET    6   A 8 VAL A 161  MSE A 167  1  O  ALA A 165   N  LEU A 140
SHEET    7   A 8 LYS A 279  PRO A 286  1  O  LEU A 280   N  PHE A 166
SHEET    8   A 8 LEU A 305  GLY A 313  1  O  ARG A 308   N  LEU A 281
SHEET    1   B 8 ARG B  52  VAL B  56  0
SHEET    2   B 8 ALA B  59  GLU B  66 -1  O  TYR B  63   N  ARG B  52
SHEET    3   B 8 ARG B  98  PRO B 102 -1  O  ALA B  99   N  GLU B  66
SHEET    4   B 8 PRO B  71  LEU B  75  1  N  VAL B  72   O  ARG B  98
SHEET    5   B 8 MSE B 138  ASP B 144  1  O  VAL B 139   N  LEU B  73
SHEET    6   B 8 VAL B 161  ALA B 169  1  O  ALA B 165   N  LEU B 140
SHEET    7   B 8 LYS B 279  PRO B 286  1  O  LEU B 280   N  PHE B 166
SHEET    8   B 8 LEU B 305  GLY B 313  1  O  ARG B 308   N  LEU B 281
LINK         C   GLY A 106                 N   MSE A 107     1555   1555  1.33
LINK         C   MSE A 107                 N   GLY A 108     1555   1555  1.33
LINK         C   TYR A 125                 N   MSE A 126     1555   1555  1.33
LINK         C   MSE A 126                 N   ASP A 127     1555   1555  1.33
LINK         C   ASP A 137                 N   MSE A 138     1555   1555  1.33
LINK         C   MSE A 138                 N   VAL A 139     1555   1555  1.33
LINK         C   GLY A 150                 N   MSE A 151     1555   1555  1.33
LINK         C   MSE A 151                 N   ARG A 152     1555   1555  1.34
LINK         C   PHE A 166                 N   MSE A 167     1555   1555  1.33
LINK         C   MSE A 167                 N   GLU A 168     1555   1555  1.33
LINK         C   PRO A 176                 N   MSE A 177     1555   1555  1.32
LINK         C   MSE A 177                 N   PRO A 178     1555   1555  1.35
LINK         C   ALA A 182                 N   MSE A 183     1555   1555  1.33
LINK         C   MSE A 183                 N   GLY A 184     1555   1555  1.33
LINK         C   LYS A 202                 N   MSE A 203     1555   1555  1.33
LINK         C   MSE A 203                 N   VAL A 204     1555   1555  1.32
LINK         C   GLU A 217                 N   MSE A 218     1555   1555  1.32
LINK         C   MSE A 218                 N   GLY A 219     1555   1555  1.33
LINK         C   GLU A 228                 N   MSE A 229     1555   1555  1.33
LINK         C   MSE A 229                 N   ALA A 230     1555   1555  1.33
LINK         C   LEU A 272                 N   MSE A 273     1555   1555  1.34
LINK         C   MSE A 273                 N   ALA A 274     1555   1555  1.33
LINK         C   GLY B 106                 N   MSE B 107     1555   1555  1.33
LINK         C   MSE B 107                 N   GLY B 108     1555   1555  1.33
LINK         C   TYR B 125                 N   MSE B 126     1555   1555  1.33
LINK         C   MSE B 126                 N   ASP B 127     1555   1555  1.34
LINK         C   ASP B 137                 N   MSE B 138     1555   1555  1.33
LINK         C   MSE B 138                 N   VAL B 139     1555   1555  1.33
LINK         C   GLY B 150                 N   MSE B 151     1555   1555  1.33
LINK         C   MSE B 151                 N   ARG B 152     1555   1555  1.34
LINK         C   PHE B 166                 N   MSE B 167     1555   1555  1.33
LINK         C   MSE B 167                 N   GLU B 168     1555   1555  1.34
LINK         C   PRO B 176                 N   MSE B 177     1555   1555  1.33
LINK         C   MSE B 177                 N   PRO B 178     1555   1555  1.35
LINK         C   ALA B 182                 N   MSE B 183     1555   1555  1.33
LINK         C   MSE B 183                 N   GLY B 184     1555   1555  1.33
LINK         C   LYS B 202                 N   MSE B 203     1555   1555  1.33
LINK         C   MSE B 203                 N   VAL B 204     1555   1555  1.33
LINK         C   GLU B 217                 N   MSE B 218     1555   1555  1.33
LINK         C   MSE B 218                 N   GLY B 219     1555   1555  1.33
LINK         C   GLU B 228                 N   MSE B 229     1555   1555  1.33
LINK         C   MSE B 229                 N   ALA B 230     1555   1555  1.33
LINK         C   LEU B 272                 N   MSE B 273     1555   1555  1.33
LINK         C   MSE B 273                 N   ALA B 274     1555   1555  1.33
CISPEP   1 ASN A   78    PRO A   79          0        -3.46
CISPEP   2 PRO A  172    PRO A  173          0         8.57
CISPEP   3 LEU A  175    PRO A  176          0        -2.04
CISPEP   4 GLU A  257    PRO A  258          0        -2.98
CISPEP   5 GLU A  285    PRO A  286          0         3.01
CISPEP   6 ASN B   78    PRO B   79          0        -2.68
CISPEP   7 PRO B  172    PRO B  173          0         5.22
CISPEP   8 LEU B  175    PRO B  176          0        -1.49
CISPEP   9 GLU B  257    PRO B  258          0        -4.39
CISPEP  10 GLU B  285    PRO B  286          0         1.41
SITE     1 AC1  4 HIS A 321  PRO A 322  HIS A 323  LEU A 324
SITE     1 AC2  5 HIS B 321  PRO B 322  HIS B 323  LEU B 324
SITE     2 AC2  5 HOH B 502
SITE     1 AC3  5 ASN A  78  TRP A 145  PHE A 210  PRO A 249
SITE     2 AC3  5 HOH A 621
SITE     1 AC4  7 LEU A 187  MSE A 218  GLY A 219  THR A 314
SITE     2 AC4  7 HIS A 315  HOH A 492  HOH A 498
SITE     1 AC5  5 LEU B 187  GLY B 219  HIS B 315  HOH B 407
SITE     2 AC5  5 HOH B 515
SITE     1 AC6  4 TRP B 145  TRP B 248  PRO B 249  HOH B 407
CRYST1   99.784   99.784  122.004  90.00  90.00 120.00 P 62         12
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.010022  0.005786  0.000000        0.00000
SCALE2      0.000000  0.011572  0.000000        0.00000
SCALE3      0.000000  0.000000  0.008196        0.00000
TER    2325      SER A 341
TER    4651      SER B 341
MASTER      551    0   28   32   16    0   10    6 5143    2  234   48
END