longtext: 3VKF-pdb

content
HEADER    CELL ADHESION                           15-NOV-11   3VKF
TITLE     CRYSTAL STRUCTURE OF NEUREXIN 1BETA/NEUROLIGIN 1 COMPLEX
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: NEUROLIGIN-1;
COMPND   3 CHAIN: A, B;
COMPND   4 FRAGMENT: ACETYLCHOLINESTERASE-LIKE DOMAIN (UNP RESIDUES 45-638);
COMPND   5 SYNONYM: NEUROLIGIN I;
COMPND   6 ENGINEERED: YES;
COMPND   7 MOL_ID: 2;
COMPND   8 MOLECULE: NEUREXIN-1-BETA;
COMPND   9 CHAIN: C, D;
COMPND  10 FRAGMENT: LNS DOMAIN (UNP RESIDUES 83-290);
COMPND  11 SYNONYM: NEUREXIN I-BETA;
COMPND  12 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS;
SOURCE   3 ORGANISM_COMMON: RAT;
SOURCE   4 ORGANISM_TAXID: 10116;
SOURCE   5 GENE: NLGN1;
SOURCE   6 EXPRESSION_SYSTEM: CRICETULUS GRISEUS;
SOURCE   7 EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER;
SOURCE   8 EXPRESSION_SYSTEM_TAXID: 10029;
SOURCE   9 EXPRESSION_SYSTEM_STRAIN: LEC 3.2.8.1;
SOURCE  10 EXPRESSION_SYSTEM_CELL_LINE: CHO;
SOURCE  11 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE  12 EXPRESSION_SYSTEM_PLASMID: PSGHV0;
SOURCE  13 MOL_ID: 2;
SOURCE  14 ORGANISM_SCIENTIFIC: BOS TAURUS;
SOURCE  15 ORGANISM_COMMON: BOVINE;
SOURCE  16 ORGANISM_TAXID: 9913;
SOURCE  17 GENE: NRXN1;
SOURCE  18 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE  19 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE  20 EXPRESSION_SYSTEM_STRAIN: BL21;
SOURCE  21 EXPRESSION_SYSTEM_VECTOR_TYPE: PLUSMID;
SOURCE  22 EXPRESSION_SYSTEM_PLASMID: PGEX-3T
KEYWDS    ALPHA/BETA HYDROLASE, BETA-SANDWICH, SYNAPSE MATULATION, CALCIUM
KEYWDS   2 BINDING, N-GLYCOSYLATION, MEMBRANE, CELL ADHESION
EXPDTA    X-RAY DIFFRACTION
AUTHOR    H.TANAKA,N.MIYAZAKI,T.NOGI,K.IWASAKI,J.TAKAGI
REVDAT   1   01-AUG-12 3VKF    0
JRNL        AUTH   H.TANAKA,N.MIYAZAKI,T.NOGI,K.IWASAKI,J.TAKAGI
JRNL        TITL   HIGHER-ORDER ARCHITECTURE OF CELL ADHESION MEDIATED BY
JRNL        TITL 2 POLYMORPHIC SYNAPTIC ADHESION MOLECULES NEUREXIN AND
JRNL        TITL 3 NEUROLIGIN
JRNL        REF    CELL REP                      V.   2   101 2012
JRNL        REFN                   ESSN 2211-1247
JRNL        DOI    10.1016/J.CELREP.2012.06.009
REMARK   2
REMARK   2 RESOLUTION.    3.30 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.2.0019
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 3.30
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 48.91
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL
REMARK   3   COMPLETENESS FOR RANGE        (%) : 96.8
REMARK   3   NUMBER OF REFLECTIONS             : 22921
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.214
REMARK   3   R VALUE            (WORKING SET) : 0.205
REMARK   3   FREE R VALUE                     : 0.287
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 10.100
REMARK   3   FREE R VALUE TEST SET COUNT      : 2586
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 3.30
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 3.38
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 1591
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 91.47
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2590
REMARK   3   BIN FREE R VALUE SET COUNT          : 179
REMARK   3   BIN FREE R VALUE                    : 0.3440
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 11251
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 69
REMARK   3   SOLVENT ATOMS            : 0
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 58.40
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 66.47
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -1.22000
REMARK   3    B22 (A**2) : 0.02000
REMARK   3    B33 (A**2) : 0.36000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : -1.32000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): NULL
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.697
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.534
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 72.166
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.915
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.842
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A): 11623 ; 0.007 ; 0.022
REMARK   3   BOND LENGTHS OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 15843 ; 1.046 ; 1.956
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  1435 ; 5.323 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   539 ;38.123 ;24.490
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  1801 ;17.007 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    56 ;15.609 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  1740 ; 0.071 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  8978 ; 0.002 ; 0.020
REMARK   3   GENERAL PLANES OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  5474 ; 0.196 ; 0.200
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  7816 ; 0.305 ; 0.200
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):   370 ; 0.122 ; 0.200
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):     5 ; 0.165 ; 0.200
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):    93 ; 0.157 ; 0.200
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):     4 ; 0.055 ; 0.200
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  7314 ; 0.225 ; 1.500
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2): 11574 ; 0.410 ; 2.000
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  4903 ; 0.388 ; 3.000
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  4269 ; 0.656 ; 4.500
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 4
REMARK   3
REMARK   3   TLS GROUP : 1
REMARK   3    NUMBER OF COMPONENTS GROUP : 2
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   C    82        C   288
REMARK   3    RESIDUE RANGE :   C  2001        C  2001
REMARK   3    ORIGIN FOR THE GROUP (A):  -49.457   -7.102   49.912
REMARK   3    T TENSOR
REMARK   3      T11:  -0.2104 T22:  -0.4154
REMARK   3      T33:  -0.1857 T12:  -0.0204
REMARK   3      T13:  -0.0118 T23:   0.0072
REMARK   3    L TENSOR
REMARK   3      L11:   7.8904 L22:   4.7144
REMARK   3      L33:   2.2680 L12:  -1.9851
REMARK   3      L13:  -2.3528 L23:   1.0554
REMARK   3    S TENSOR
REMARK   3      S11:   0.0879 S12:   0.0029 S13:  -0.1383
REMARK   3      S21:   0.0762 S22:  -0.0961 S23:   0.3074
REMARK   3      S31:   0.0011 S32:  -0.0206 S33:   0.0082
REMARK   3
REMARK   3   TLS GROUP : 2
REMARK   3    NUMBER OF COMPONENTS GROUP : 2
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   D    82        D   288
REMARK   3    RESIDUE RANGE :   D  2001        D  2001
REMARK   3    ORIGIN FOR THE GROUP (A):   24.865   -2.006  -15.517
REMARK   3    T TENSOR
REMARK   3      T11:  -0.1153 T22:  -0.1062
REMARK   3      T33:  -0.1704 T12:   0.0454
REMARK   3      T13:  -0.0477 T23:   0.0822
REMARK   3    L TENSOR
REMARK   3      L11:  10.8740 L22:   3.6856
REMARK   3      L33:   3.4474 L12:   0.9156
REMARK   3      L13:  -2.3434 L23:   1.8463
REMARK   3    S TENSOR
REMARK   3      S11:   0.1303 S12:  -0.2886 S13:   0.5725
REMARK   3      S21:   0.0364 S22:   0.0506 S23:  -0.1518
REMARK   3      S31:   0.0014 S32:   0.0844 S33:  -0.1809
REMARK   3
REMARK   3   TLS GROUP : 3
REMARK   3    NUMBER OF COMPONENTS GROUP : 2
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A    52        A   634
REMARK   3    RESIDUE RANGE :   A  2001        A  2004
REMARK   3    ORIGIN FOR THE GROUP (A):  -8.3500  -1.1511  48.7848
REMARK   3    T TENSOR
REMARK   3      T11:  -0.2943 T22:  -0.3711
REMARK   3      T33:  -0.1999 T12:  -0.0230
REMARK   3      T13:   0.0230 T23:   0.0349
REMARK   3    L TENSOR
REMARK   3      L11:   2.0882 L22:   1.3837
REMARK   3      L33:   2.3528 L12:  -0.1052
REMARK   3      L13:   0.0420 L23:   0.1139
REMARK   3    S TENSOR
REMARK   3      S11:   0.0107 S12:  -0.0125 S13:   0.0242
REMARK   3      S21:  -0.1276 S22:  -0.0211 S23:  -0.1185
REMARK   3      S31:  -0.1122 S32:   0.0891 S33:   0.0104
REMARK   3
REMARK   3   TLS GROUP : 4
REMARK   3    NUMBER OF COMPONENTS GROUP : 2
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   B    52        B   634
REMARK   3    RESIDUE RANGE :   B  2001        B  2001
REMARK   3    ORIGIN FOR THE GROUP (A): -16.6257   1.8414 -12.2669
REMARK   3    T TENSOR
REMARK   3      T11:  -0.1337 T22:  -0.1156
REMARK   3      T33:  -0.1722 T12:  -0.0430
REMARK   3      T13:  -0.0201 T23:  -0.0340
REMARK   3    L TENSOR
REMARK   3      L11:   1.8259 L22:   0.9964
REMARK   3      L33:   4.2944 L12:  -0.1321
REMARK   3      L13:   0.2580 L23:  -0.6897
REMARK   3    S TENSOR
REMARK   3      S11:   0.0317 S12:   0.0825 S13:  -0.0786
REMARK   3      S21:  -0.0202 S22:  -0.0637 S23:   0.0870
REMARK   3      S31:  -0.1460 S32:  -0.1315 S33:   0.0320
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING
REMARK   3  POSITIONS
REMARK   4
REMARK   4 3VKF COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 01-DEC-11.
REMARK 100 THE RCSB ID CODE IS RCSB095155.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 26-FEB-08
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 8.0
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : PHOTON FACTORY
REMARK 200  BEAMLINE                       : BL-17A
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.0000
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 270
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 25519
REMARK 200  RESOLUTION RANGE HIGH      (A) : 3.300
REMARK 200  RESOLUTION RANGE LOW       (A) : 48.910
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : -3.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 97.3
REMARK 200  DATA REDUNDANCY                : 3.700
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : NULL
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.30
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 3.48
REMARK 200  COMPLETENESS FOR SHELL     (%) : 93.7
REMARK 200  DATA REDUNDANCY IN SHELL       : 3.70
REMARK 200  R MERGE FOR SHELL          (I) : 0.31100
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 4.300
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: MOLREP
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 52.66
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.60
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1M SODIUM CHLORIDE, 0.005M CALCIUM
REMARK 280  CHLORIDE, PH 8.0, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       47.59300
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3, 4, 5
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 3
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 4
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 5
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     SER A    45
REMARK 465     GLN A    46
REMARK 465     LYS A    47
REMARK 465     LEU A    48
REMARK 465     ASP A    49
REMARK 465     ASP A    50
REMARK 465     VAL A    51
REMARK 465     ASP A   579
REMARK 465     THR A   580
REMARK 465     LYS A   581
REMARK 465     PHE A   582
REMARK 465     ILE A   583
REMARK 465     HIS A   584
REMARK 465     THR A   585
REMARK 465     LYS A   586
REMARK 465     PRO A   587
REMARK 465     ASN A   588
REMARK 465     ARG A   589
REMARK 465     PHE A   590
REMARK 465     GLU A   591
REMARK 465     GLU A   592
REMARK 465     ASN A   635
REMARK 465     LEU A   636
REMARK 465     ASN A   637
REMARK 465     ASP A   638
REMARK 465     SER B    45
REMARK 465     GLN B    46
REMARK 465     LYS B    47
REMARK 465     LEU B    48
REMARK 465     ASP B    49
REMARK 465     ASP B    50
REMARK 465     VAL B    51
REMARK 465     GLU B   163
REMARK 465     ASP B   164
REMARK 465     VAL B   165
REMARK 465     LYS B   166
REMARK 465     ARG B   167
REMARK 465     ILE B   168
REMARK 465     SER B   169
REMARK 465     LYS B   170
REMARK 465     GLU B   171
REMARK 465     CYS B   172
REMARK 465     ALA B   173
REMARK 465     ARG B   174
REMARK 465     LYS B   175
REMARK 465     PRO B   176
REMARK 465     GLY B   177
REMARK 465     LYS B   178
REMARK 465     LYS B   179
REMARK 465     ILE B   180
REMARK 465     CYS B   181
REMARK 465     ARG B   182
REMARK 465     LYS B   183
REMARK 465     GLY B   184
REMARK 465     ASP B   185
REMARK 465     ILE B   186
REMARK 465     ARG B   187
REMARK 465     ASP B   188
REMARK 465     SER B   189
REMARK 465     GLY B   190
REMARK 465     GLY B   444
REMARK 465     TYR B   445
REMARK 465     PRO B   446
REMARK 465     GLU B   447
REMARK 465     GLY B   448
REMARK 465     ASP B   579
REMARK 465     THR B   580
REMARK 465     LYS B   581
REMARK 465     PHE B   582
REMARK 465     ILE B   583
REMARK 465     HIS B   584
REMARK 465     THR B   585
REMARK 465     LYS B   586
REMARK 465     PRO B   587
REMARK 465     ASN B   588
REMARK 465     ARG B   589
REMARK 465     PHE B   590
REMARK 465     GLU B   591
REMARK 465     GLU B   592
REMARK 465     ASN B   635
REMARK 465     LEU B   636
REMARK 465     ASN B   637
REMARK 465     ASP B   638
REMARK 465     GLY C    81
REMARK 465     GLU C   289
REMARK 465     VAL C   290
REMARK 465     SER C   291
REMARK 465     GLY D    81
REMARK 465     GLU D   289
REMARK 465     VAL D   290
REMARK 465     SER D   291
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    GLU A  72      -57.45    -23.77
REMARK 500    ILE A  73      -81.31    -69.02
REMARK 500    ASP A 106     -154.91    -94.92
REMARK 500    ARG A 125        4.25    -65.50
REMARK 500    LYS A 183       72.04   -155.56
REMARK 500    SER A 203       28.17   -143.73
REMARK 500    THR A 208      127.87   -172.20
REMARK 500    LEU A 232     -162.56   -116.95
REMARK 500    ASP A 242     -145.45   -176.32
REMARK 500    PRO A 272        3.09    -66.88
REMARK 500    VAL A 367       76.03   -114.25
REMARK 500    ASP A 383      -81.44   -152.80
REMARK 500    GLU A 397       59.22   -110.19
REMARK 500    GLU A 417       48.53    -65.66
REMARK 500    ASN A 418      -35.32   -143.91
REMARK 500    ASP A 424       63.46     39.42
REMARK 500    TYR A 445     -109.68   -103.45
REMARK 500    PRO A 446     -177.65    -61.49
REMARK 500    GLU A 447      -56.70    108.11
REMARK 500    ASP A 465       65.45   -151.38
REMARK 500    PHE A 499       36.71    -87.90
REMARK 500    THR A 514     -150.54    -86.77
REMARK 500    ASP A 522     -153.46    -86.10
REMARK 500    ASP A 527      -16.73    -45.57
REMARK 500    TRP A 595       96.93    -63.55
REMARK 500    HIS A 617       80.57     45.65
REMARK 500    GLU A 628      -60.02   -103.22
REMARK 500    ASN B  70       40.58    -79.05
REMARK 500    PRO B  88      109.19    -49.36
REMARK 500    ASP B 106     -143.86    -95.52
REMARK 500    ASN B 109       71.52    -66.85
REMARK 500    SER B 203       14.25   -140.06
REMARK 500    ALA B 218      -70.00    -64.80
REMARK 500    ASN B 343       86.86    -68.92
REMARK 500    SER B 345      -71.47    -45.42
REMARK 500    TYR B 372       -6.69     80.52
REMARK 500    ASP B 383      -70.82   -136.32
REMARK 500    ASN B 418        3.55    -62.40
REMARK 500    PRO B 502       88.57    -60.20
REMARK 500    ASN B 547       98.02    -60.33
REMARK 500    ASP B 571      108.94   -167.60
REMARK 500    GLN B 603       63.83     38.93
REMARK 500    HIS B 617       75.83     40.67
REMARK 500    HIS B 632       72.27   -105.01
REMARK 500    SER C  89     -158.44   -121.51
REMARK 500    LYS C  90      123.20    -34.34
REMARK 500    PRO C 100      137.70    -37.60
REMARK 500    THR C 155      -87.85    -91.50
REMARK 500    GLU C 162       90.22    -69.13
REMARK 500    ASN C 164       61.72   -110.73
REMARK 500
REMARK 500 THIS ENTRY HAS      63 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 620
REMARK 620 METAL COORDINATION
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA D2001  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 VAL D 153   O
REMARK 620 2 ILE D 235   O    97.6
REMARK 620 3 ASN D 237   OD1 150.5 102.6
REMARK 620 4 ASP D 136   OD2  78.2  97.8  77.9
REMARK 620 N                    1     2     3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA C2001  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ASN C 237   OD1
REMARK 620 2 VAL C 153   O   135.1
REMARK 620 3 ASP C 136   OD2  68.8  75.7
REMARK 620 4 ILE C 235   O    72.2  70.9  71.4
REMARK 620 N                    1     2     3
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA C 2001
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA D 2001
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAG A 2001
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAG A 2002
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAG A 2003
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE BMA A 2004
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAG B 2001
REMARK 999
REMARK 999 SEQUENCE
REMARK 999 SEQUENCE OF THE CHAIN A/B WAS BASED ON ISOFORM 3 OF DATABASE Q62765
REMARK 999 (NLGN1_RAT). SEQUENCE OF THE CHAIN C/D WAS BASED ON ISOFORM 3B OF
REMARK 999 DATABASE Q28142 (NRX1B_BOVIN).
DBREF  3VKF A   45   638  UNP    Q62765   NLGN1_RAT       45    638
DBREF  3VKF B   45   638  UNP    Q62765   NLGN1_RAT       45    638
DBREF  3VKF C   83   290  UNP    Q28142   NRX1B_BOVIN     83    290
DBREF  3VKF D   83   290  UNP    Q28142   NRX1B_BOVIN     83    290
SEQADV 3VKF GLY C   81  UNP  Q28142              EXPRESSION TAG
SEQADV 3VKF SER C   82  UNP  Q28142              EXPRESSION TAG
SEQADV 3VKF SER C  291  UNP  Q28142              EXPRESSION TAG
SEQADV 3VKF GLY D   81  UNP  Q28142              EXPRESSION TAG
SEQADV 3VKF SER D   82  UNP  Q28142              EXPRESSION TAG
SEQADV 3VKF SER D  291  UNP  Q28142              EXPRESSION TAG
SEQRES   1 A  585  SER GLN LYS LEU ASP ASP VAL ASP PRO LEU VAL THR THR
SEQRES   2 A  585  ASN PHE GLY LYS ILE ARG GLY ILE LYS LYS GLU LEU ASN
SEQRES   3 A  585  ASN GLU ILE LEU GLY PRO VAL ILE GLN PHE LEU GLY VAL
SEQRES   4 A  585  PRO TYR ALA ALA PRO PRO THR GLY GLU HIS ARG PHE GLN
SEQRES   5 A  585  PRO PRO GLU PRO PRO SER PRO TRP SER ASP ILE ARG ASN
SEQRES   6 A  585  ALA THR GLN PHE ALA PRO VAL CYS PRO GLN ASN ILE ILE
SEQRES   7 A  585  ASP GLY ARG LEU PRO GLU VAL MET LEU PRO VAL TRP PHE
SEQRES   8 A  585  THR ASN ASN LEU ASP VAL VAL SER SER TYR VAL GLN ASP
SEQRES   9 A  585  GLN SER GLU ASP CYS LEU TYR LEU ASN ILE TYR VAL PRO
SEQRES  10 A  585  THR GLU ASP VAL LYS ARG ILE SER LYS GLU CYS ALA ARG
SEQRES  11 A  585  LYS PRO GLY LYS LYS ILE CYS ARG LYS GLY ASP ILE ARG
SEQRES  12 A  585  ASP SER GLY GLY PRO LYS PRO VAL MET VAL TYR ILE HIS
SEQRES  13 A  585  GLY GLY SER TYR MET GLU GLY THR GLY ASN LEU TYR ASP
SEQRES  14 A  585  GLY SER VAL LEU ALA SER TYR GLY ASN VAL ILE VAL ILE
SEQRES  15 A  585  THR VAL ASN TYR ARG LEU GLY VAL LEU GLY PHE LEU SER
SEQRES  16 A  585  THR GLY ASP GLN ALA ALA LYS GLY ASN TYR GLY LEU LEU
SEQRES  17 A  585  ASP LEU ILE GLN ALA LEU ARG TRP THR SER GLU ASN ILE
SEQRES  18 A  585  GLY PHE PHE GLY GLY ASP PRO LEU ARG ILE THR VAL PHE
SEQRES  19 A  585  GLY SER GLY ALA GLY GLY SER CYS VAL ASN LEU LEU THR
SEQRES  20 A  585  LEU SER HIS TYR SER GLU GLY LEU PHE GLN ARG ALA ILE
SEQRES  21 A  585  ALA GLN SER GLY THR ALA LEU SER SER TRP ALA VAL SER
SEQRES  22 A  585  PHE GLN PRO ALA LYS TYR ALA ARG ILE LEU ALA THR LYS
SEQRES  23 A  585  VAL GLY CYS ASN VAL SER ASP THR VAL GLU LEU VAL GLU
SEQRES  24 A  585  CYS LEU GLN LYS LYS PRO TYR LYS GLU LEU VAL ASP GLN
SEQRES  25 A  585  ASP VAL GLN PRO ALA ARG TYR HIS ILE ALA PHE GLY PRO
SEQRES  26 A  585  VAL ILE ASP GLY ASP VAL ILE PRO ASP ASP PRO GLN ILE
SEQRES  27 A  585  LEU MET GLU GLN GLY GLU PHE LEU ASN TYR ASP ILE MET
SEQRES  28 A  585  LEU GLY VAL ASN GLN GLY GLU GLY LEU LYS PHE VAL GLU
SEQRES  29 A  585  ASN ILE VAL ASP SER ASP ASP GLY VAL SER ALA SER ASP
SEQRES  30 A  585  PHE ASP PHE ALA VAL SER ASN PHE VAL ASP ASN LEU TYR
SEQRES  31 A  585  GLY TYR PRO GLU GLY LYS ASP VAL LEU ARG GLU THR ILE
SEQRES  32 A  585  LYS PHE MET TYR THR ASP TRP ALA ASP ARG HIS ASN PRO
SEQRES  33 A  585  GLU THR ARG ARG LYS THR LEU LEU ALA LEU PHE THR ASP
SEQRES  34 A  585  HIS GLN TRP VAL ALA PRO ALA VAL ALA THR ALA ASP LEU
SEQRES  35 A  585  HIS SER ASN PHE GLY SER PRO THR TYR PHE TYR ALA PHE
SEQRES  36 A  585  TYR HIS HIS CYS GLN THR ASP GLN VAL PRO ALA TRP ALA
SEQRES  37 A  585  ASP ALA ALA HIS GLY ASP GLU VAL PRO TYR VAL LEU GLY
SEQRES  38 A  585  ILE PRO MET ILE GLY PRO THR GLU LEU PHE PRO CYS ASN
SEQRES  39 A  585  PHE SER LYS ASN ASP VAL MET LEU SER ALA VAL VAL MET
SEQRES  40 A  585  THR TYR TRP THR ASN PHE ALA LYS THR GLY ASP PRO ASN
SEQRES  41 A  585  GLN PRO VAL PRO GLN ASP THR LYS PHE ILE HIS THR LYS
SEQRES  42 A  585  PRO ASN ARG PHE GLU GLU VAL ALA TRP THR ARG TYR SER
SEQRES  43 A  585  GLN LYS ASP GLN LEU TYR LEU HIS ILE GLY LEU LYS PRO
SEQRES  44 A  585  ARG VAL LYS GLU HIS TYR ARG ALA ASN LYS VAL ASN LEU
SEQRES  45 A  585  TRP LEU GLU LEU VAL PRO HIS LEU HIS ASN LEU ASN ASP
SEQRES   1 B  585  SER GLN LYS LEU ASP ASP VAL ASP PRO LEU VAL THR THR
SEQRES   2 B  585  ASN PHE GLY LYS ILE ARG GLY ILE LYS LYS GLU LEU ASN
SEQRES   3 B  585  ASN GLU ILE LEU GLY PRO VAL ILE GLN PHE LEU GLY VAL
SEQRES   4 B  585  PRO TYR ALA ALA PRO PRO THR GLY GLU HIS ARG PHE GLN
SEQRES   5 B  585  PRO PRO GLU PRO PRO SER PRO TRP SER ASP ILE ARG ASN
SEQRES   6 B  585  ALA THR GLN PHE ALA PRO VAL CYS PRO GLN ASN ILE ILE
SEQRES   7 B  585  ASP GLY ARG LEU PRO GLU VAL MET LEU PRO VAL TRP PHE
SEQRES   8 B  585  THR ASN ASN LEU ASP VAL VAL SER SER TYR VAL GLN ASP
SEQRES   9 B  585  GLN SER GLU ASP CYS LEU TYR LEU ASN ILE TYR VAL PRO
SEQRES  10 B  585  THR GLU ASP VAL LYS ARG ILE SER LYS GLU CYS ALA ARG
SEQRES  11 B  585  LYS PRO GLY LYS LYS ILE CYS ARG LYS GLY ASP ILE ARG
SEQRES  12 B  585  ASP SER GLY GLY PRO LYS PRO VAL MET VAL TYR ILE HIS
SEQRES  13 B  585  GLY GLY SER TYR MET GLU GLY THR GLY ASN LEU TYR ASP
SEQRES  14 B  585  GLY SER VAL LEU ALA SER TYR GLY ASN VAL ILE VAL ILE
SEQRES  15 B  585  THR VAL ASN TYR ARG LEU GLY VAL LEU GLY PHE LEU SER
SEQRES  16 B  585  THR GLY ASP GLN ALA ALA LYS GLY ASN TYR GLY LEU LEU
SEQRES  17 B  585  ASP LEU ILE GLN ALA LEU ARG TRP THR SER GLU ASN ILE
SEQRES  18 B  585  GLY PHE PHE GLY GLY ASP PRO LEU ARG ILE THR VAL PHE
SEQRES  19 B  585  GLY SER GLY ALA GLY GLY SER CYS VAL ASN LEU LEU THR
SEQRES  20 B  585  LEU SER HIS TYR SER GLU GLY LEU PHE GLN ARG ALA ILE
SEQRES  21 B  585  ALA GLN SER GLY THR ALA LEU SER SER TRP ALA VAL SER
SEQRES  22 B  585  PHE GLN PRO ALA LYS TYR ALA ARG ILE LEU ALA THR LYS
SEQRES  23 B  585  VAL GLY CYS ASN VAL SER ASP THR VAL GLU LEU VAL GLU
SEQRES  24 B  585  CYS LEU GLN LYS LYS PRO TYR LYS GLU LEU VAL ASP GLN
SEQRES  25 B  585  ASP VAL GLN PRO ALA ARG TYR HIS ILE ALA PHE GLY PRO
SEQRES  26 B  585  VAL ILE ASP GLY ASP VAL ILE PRO ASP ASP PRO GLN ILE
SEQRES  27 B  585  LEU MET GLU GLN GLY GLU PHE LEU ASN TYR ASP ILE MET
SEQRES  28 B  585  LEU GLY VAL ASN GLN GLY GLU GLY LEU LYS PHE VAL GLU
SEQRES  29 B  585  ASN ILE VAL ASP SER ASP ASP GLY VAL SER ALA SER ASP
SEQRES  30 B  585  PHE ASP PHE ALA VAL SER ASN PHE VAL ASP ASN LEU TYR
SEQRES  31 B  585  GLY TYR PRO GLU GLY LYS ASP VAL LEU ARG GLU THR ILE
SEQRES  32 B  585  LYS PHE MET TYR THR ASP TRP ALA ASP ARG HIS ASN PRO
SEQRES  33 B  585  GLU THR ARG ARG LYS THR LEU LEU ALA LEU PHE THR ASP
SEQRES  34 B  585  HIS GLN TRP VAL ALA PRO ALA VAL ALA THR ALA ASP LEU
SEQRES  35 B  585  HIS SER ASN PHE GLY SER PRO THR TYR PHE TYR ALA PHE
SEQRES  36 B  585  TYR HIS HIS CYS GLN THR ASP GLN VAL PRO ALA TRP ALA
SEQRES  37 B  585  ASP ALA ALA HIS GLY ASP GLU VAL PRO TYR VAL LEU GLY
SEQRES  38 B  585  ILE PRO MET ILE GLY PRO THR GLU LEU PHE PRO CYS ASN
SEQRES  39 B  585  PHE SER LYS ASN ASP VAL MET LEU SER ALA VAL VAL MET
SEQRES  40 B  585  THR TYR TRP THR ASN PHE ALA LYS THR GLY ASP PRO ASN
SEQRES  41 B  585  GLN PRO VAL PRO GLN ASP THR LYS PHE ILE HIS THR LYS
SEQRES  42 B  585  PRO ASN ARG PHE GLU GLU VAL ALA TRP THR ARG TYR SER
SEQRES  43 B  585  GLN LYS ASP GLN LEU TYR LEU HIS ILE GLY LEU LYS PRO
SEQRES  44 B  585  ARG VAL LYS GLU HIS TYR ARG ALA ASN LYS VAL ASN LEU
SEQRES  45 B  585  TRP LEU GLU LEU VAL PRO HIS LEU HIS ASN LEU ASN ASP
SEQRES   1 C  181  GLY SER GLY THR THR TYR ILE PHE SER LYS GLY GLY GLY
SEQRES   2 C  181  GLN ILE THR TYR LYS TRP PRO PRO ASN ASP ARG PRO SER
SEQRES   3 C  181  THR ARG ALA ASP ARG LEU ALA ILE GLY PHE SER THR VAL
SEQRES   4 C  181  GLN LYS GLU ALA VAL LEU VAL ARG VAL ASP SER SER SER
SEQRES   5 C  181  GLY LEU GLY ASP TYR LEU GLU LEU HIS ILE HIS GLN GLY
SEQRES   6 C  181  LYS ILE GLY VAL LYS PHE ASN VAL GLY THR ASP ASP ILE
SEQRES   7 C  181  ALA ILE GLU GLU SER ASN ALA ILE ILE ASN ASP GLY LYS
SEQRES   8 C  181  TYR HIS VAL VAL ARG PHE THR ARG SER GLY GLY ASN ALA
SEQRES   9 C  181  THR LEU GLN VAL ASP SER TRP PRO VAL ILE GLU ARG TYR
SEQRES  10 C  181  PRO ALA GLY ARG GLN LEU THR ILE PHE ASN SER GLN ALA
SEQRES  11 C  181  THR ILE ILE ILE GLY GLY LYS GLU GLN GLY GLN PRO PHE
SEQRES  12 C  181  GLN GLY GLN LEU SER GLY LEU TYR TYR ASN GLY LEU LYS
SEQRES  13 C  181  VAL LEU ASN MET ALA ALA GLU ASN ASP ALA ASN ILE ALA
SEQRES  14 C  181  ILE VAL GLY ASN VAL ARG LEU VAL GLY GLU VAL SER
SEQRES   1 D  181  GLY SER GLY THR THR TYR ILE PHE SER LYS GLY GLY GLY
SEQRES   2 D  181  GLN ILE THR TYR LYS TRP PRO PRO ASN ASP ARG PRO SER
SEQRES   3 D  181  THR ARG ALA ASP ARG LEU ALA ILE GLY PHE SER THR VAL
SEQRES   4 D  181  GLN LYS GLU ALA VAL LEU VAL ARG VAL ASP SER SER SER
SEQRES   5 D  181  GLY LEU GLY ASP TYR LEU GLU LEU HIS ILE HIS GLN GLY
SEQRES   6 D  181  LYS ILE GLY VAL LYS PHE ASN VAL GLY THR ASP ASP ILE
SEQRES   7 D  181  ALA ILE GLU GLU SER ASN ALA ILE ILE ASN ASP GLY LYS
SEQRES   8 D  181  TYR HIS VAL VAL ARG PHE THR ARG SER GLY GLY ASN ALA
SEQRES   9 D  181  THR LEU GLN VAL ASP SER TRP PRO VAL ILE GLU ARG TYR
SEQRES  10 D  181  PRO ALA GLY ARG GLN LEU THR ILE PHE ASN SER GLN ALA
SEQRES  11 D  181  THR ILE ILE ILE GLY GLY LYS GLU GLN GLY GLN PRO PHE
SEQRES  12 D  181  GLN GLY GLN LEU SER GLY LEU TYR TYR ASN GLY LEU LYS
SEQRES  13 D  181  VAL LEU ASN MET ALA ALA GLU ASN ASP ALA ASN ILE ALA
SEQRES  14 D  181  ILE VAL GLY ASN VAL ARG LEU VAL GLY GLU VAL SER
MODRES 3VKF ASN A  343  ASN  GLYCOSYLATION SITE
MODRES 3VKF ASN B  343  ASN  GLYCOSYLATION SITE
MODRES 3VKF ASN A  547  ASN  GLYCOSYLATION SITE
HET     CA  C2001       1
HET     CA  D2001       1
HET    NAG  A2001      14
HET    NAG  A2002      14
HET    NAG  A2003      14
HET    BMA  A2004      11
HET    NAG  B2001      14
HETNAM      CA CALCIUM ION
HETNAM     NAG N-ACETYL-D-GLUCOSAMINE
HETNAM     BMA BETA-D-MANNOSE
FORMUL   5   CA    2(CA 2+)
FORMUL   7  NAG    4(C8 H15 N O6)
FORMUL   8  BMA    C6 H12 O6
HELIX    1   1 THR A   90  ARG A   94  5                                   5
HELIX    2   2 PRO A  132  ASN A  138  1                                   7
HELIX    3   3 ASN A  138  GLN A  147  1                                  10
HELIX    4   4 ILE A  168  LYS A  175  1                                   8
HELIX    5   5 LYS A  178  LYS A  183  1                                   6
HELIX    6   6 THR A  208  TYR A  212  5                                   5
HELIX    7   7 GLY A  214  GLY A  221  1                                   8
HELIX    8   8 ASN A  248  GLY A  269  1                                  22
HELIX    9   9 GLY A  281  SER A  293  1                                  13
HELIX   10  10 HIS A  294  GLU A  297  5                                   4
HELIX   11  11 GLN A  328  VAL A  340  1                                  13
HELIX   12  12 ASP A  346  LYS A  357  1                                  12
HELIX   13  13 PRO A  358  ASP A  364  1                                   7
HELIX   14  14 ASP A  388  GLN A  395  1                                   8
HELIX   15  15 GLY A  412  VAL A  416  5                                   5
HELIX   16  16 SER A  427  TYR A  443  1                                  17
HELIX   17  17 GLY A  448  TYR A  460  1                                  13
HELIX   18  18 ASP A  462  ARG A  466  5                                   5
HELIX   19  19 ASN A  468  TRP A  485  1                                  18
HELIX   20  20 TRP A  485  PHE A  499  1                                  15
HELIX   21  21 GLU A  528  GLY A  534  1                                   7
HELIX   22  22 ILE A  535  ILE A  538  5                                   4
HELIX   23  23 SER A  549  GLY A  570  1                                  22
HELIX   24  24 ARG A  619  GLU A  628  1                                  10
HELIX   25  25 LEU A  629  LEU A  633  5                                   5
HELIX   26  26 THR B   90  ARG B   94  5                                   5
HELIX   27  27 PRO B  132  ASN B  138  1                                   7
HELIX   28  28 ASN B  138  SER B  143  1                                   6
HELIX   29  29 THR B  208  TYR B  212  5                                   5
HELIX   30  30 GLY B  214  ASN B  222  1                                   9
HELIX   31  31 LEU B  232  LEU B  238  1                                   7
HELIX   32  32 ASN B  248  ILE B  265  1                                  18
HELIX   33  33 GLY B  281  LEU B  292  1                                  12
HELIX   34  34 SER B  293  GLU B  297  5                                   5
HELIX   35  35 GLN B  328  VAL B  340  1                                  13
HELIX   36  36 ASP B  346  LYS B  357  1                                  12
HELIX   37  37 PRO B  358  ASP B  364  1                                   7
HELIX   38  38 GLN B  390  GLN B  395  1                                   6
HELIX   39  39 GLY B  412  GLU B  417  1                                   6
HELIX   40  40 ASN B  418  VAL B  420  5                                   3
HELIX   41  41 SER B  427  TYR B  443  1                                  17
HELIX   42  42 ASP B  450  TYR B  460  1                                  11
HELIX   43  43 GLU B  470  TRP B  485  1                                  16
HELIX   44  44 TRP B  485  ASN B  498  1                                  14
HELIX   45  45 GLU B  528  LEU B  533  1                                   6
HELIX   46  46 GLY B  534  ILE B  538  5                                   5
HELIX   47  47 SER B  549  GLY B  570  1                                  22
HELIX   48  48 ARG B  619  LEU B  629  1                                  11
HELIX   49  49 PRO C  100  ARG C  104  5                                   5
HELIX   50  50 VAL C  267  GLU C  273  1                                   7
HELIX   51  51 PRO D  100  ARG D  104  5                                   5
HELIX   52  52 GLY D  246  GLY D  250  5                                   5
HELIX   53  53 VAL D  267  ALA D  271  1                                   5
HELIX   54  54 ALA D  272  ASN D  274  5                                   3
SHEET    1   A 3 LEU A  54  THR A  57  0
SHEET    2   A 3 GLY A  60  ARG A  63 -1  O  ILE A  62   N  VAL A  55
SHEET    3   A 3 ILE A 107  ASN A 109  1  O  ARG A 108   N  ARG A  63
SHEET    1   B11 ILE A  65  LYS A  67  0
SHEET    2   B11 VAL A  77  PRO A  84 -1  O  GLN A  79   N  ILE A  65
SHEET    3   B11 TYR A 155  PRO A 161 -1  O  VAL A 160   N  ILE A  78
SHEET    4   B11 ILE A 224  VAL A 228 -1  O  VAL A 225   N  TYR A 159
SHEET    5   B11 LYS A 193  ILE A 199  1  N  MET A 196   O  ILE A 226
SHEET    6   B11 GLY A 270  SER A 280  1  O  PHE A 278   N  VAL A 197
SHEET    7   B11 ARG A 311  GLN A 315  1  O  GLN A 315   N  GLY A 279
SHEET    8   B11 ASP A 402  ASN A 408  1  O  ASP A 402   N  ALA A 312
SHEET    9   B11 THR A 503  PHE A 508  1  O  TYR A 504   N  LEU A 405
SHEET   10   B11 LEU A 604  ILE A 608  1  O  LEU A 606   N  PHE A 505
SHEET   11   B11 ARG A 613  GLU A 616 -1  O  ARG A 613   N  HIS A 607
SHEET    1   C 3 LEU B  54  THR B  57  0
SHEET    2   C 3 GLY B  60  ARG B  63 -1  O  GLY B  60   N  THR B  57
SHEET    3   C 3 ILE B 107  ASN B 109  1  O  ARG B 108   N  LYS B  61
SHEET    1   D 8 ILE B  65  LYS B  67  0
SHEET    2   D 8 VAL B  77  PRO B  84 -1  O  GLN B  79   N  ILE B  65
SHEET    3   D 8 TYR B 155  PRO B 161 -1  O  VAL B 160   N  ILE B  78
SHEET    4   D 8 ILE B 224  VAL B 228 -1  O  THR B 227   N  ASN B 157
SHEET    5   D 8 LYS B 193  ILE B 199  1  N  TYR B 198   O  ILE B 226
SHEET    6   D 8 GLY B 270  SER B 280  1  O  PHE B 278   N  VAL B 197
SHEET    7   D 8 ARG B 311  GLN B 315  1  O  GLN B 315   N  GLY B 279
SHEET    8   D 8 ASP B 402  MET B 404  1  O  ASP B 402   N  ALA B 312
SHEET    1   E 4 VAL B 407  ASN B 408  0
SHEET    2   E 4 PHE B 505  PHE B 508  1  O  TYR B 506   N  VAL B 407
SHEET    3   E 4 LEU B 604  ILE B 608  1  O  ILE B 608   N  ALA B 507
SHEET    4   E 4 ARG B 613  GLU B 616 -1  O  ARG B 613   N  HIS B 607
SHEET    1   F 8 ILE C 158  GLU C 161  0
SHEET    2   F 8 LYS C 146  ASN C 152 -1  N  PHE C 151   O  ILE C 158
SHEET    3   F 8 TYR C 137  HIS C 143 -1  N  GLU C 139   O  LYS C 150
SHEET    4   F 8 ALA C 123  SER C 130 -1  N  VAL C 126   O  LEU C 140
SHEET    5   F 8 GLN C 239  ILE C 244 -1  O  ILE C 243   N  ARG C 127
SHEET    6   F 8 TYR C  86  LYS C  98 -1  N  TYR C  97   O  ILE C 242
SHEET    7   F 8 GLY C 255  TYR C 262 -1  O  LEU C 257   N  TYR C  86
SHEET    8   F 8 LEU C 265  LYS C 266 -1  O  LEU C 265   N  TYR C 262
SHEET    1   G 7 ILE C 194  ARG C 196  0
SHEET    2   G 7 ASN C 183  VAL C 188 -1  N  LEU C 186   O  ILE C 194
SHEET    3   G 7 HIS C 173  SER C 180 -1  N  ARG C 176   O  GLN C 187
SHEET    4   G 7 ALA C 109  THR C 118 -1  N  LEU C 112   O  PHE C 177
SHEET    5   G 7 GLY C 255  TYR C 262 -1  O  SER C 258   N  GLY C 115
SHEET    6   G 7 TYR C  86  LYS C  98 -1  N  TYR C  86   O  LEU C 257
SHEET    7   G 7 ILE C 278  LEU C 286 -1  O  ARG C 285   N  ILE C  87
SHEET    1   H 8 ILE D 158  GLU D 161  0
SHEET    2   H 8 LYS D 146  ASN D 152 -1  N  VAL D 149   O  ILE D 160
SHEET    3   H 8 TYR D 137  HIS D 143 -1  N  HIS D 143   O  LYS D 146
SHEET    4   H 8 ALA D 123  SER D 130 -1  N  VAL D 126   O  LEU D 140
SHEET    5   H 8 GLN D 239  ILE D 244 -1  O  ALA D 240   N  ASP D 129
SHEET    6   H 8 THR D  85  LYS D  98 -1  N  TYR D  97   O  ILE D 242
SHEET    7   H 8 GLY D 255  TYR D 262 -1  O  GLY D 255   N  PHE D  88
SHEET    8   H 8 LEU D 265  LYS D 266 -1  O  LEU D 265   N  TYR D 262
SHEET    1   I 7 ILE D 194  ARG D 196  0
SHEET    2   I 7 ASN D 183  VAL D 188 -1  N  ALA D 184   O  ARG D 196
SHEET    3   I 7 HIS D 173  SER D 180 -1  N  THR D 178   O  THR D 185
SHEET    4   I 7 ALA D 109  THR D 118 -1  N  LEU D 112   O  PHE D 177
SHEET    5   I 7 GLY D 255  TYR D 262 -1  O  TYR D 261   N  ALA D 113
SHEET    6   I 7 THR D  85  LYS D  98 -1  N  PHE D  88   O  GLY D 255
SHEET    7   I 7 ALA D 279  LEU D 286 -1  O  ARG D 285   N  ILE D  87
SSBOND   1 CYS A  117    CYS A  153                          1555   1555  2.05
SSBOND   2 CYS A  172    CYS A  181                          1555   1555  2.03
SSBOND   3 CYS A  342    CYS A  353                          1555   1555  2.03
SSBOND   4 CYS A  512    CYS A  546                          1555   1555  2.04
SSBOND   5 CYS B  117    CYS B  153                          1555   1555  2.04
SSBOND   6 CYS B  342    CYS B  353                          1555   1555  2.04
SSBOND   7 CYS B  512    CYS B  546                          1555   1555  2.04
LINK         ND2 ASN A 343                 C1  NAG A2001     1555   1555  1.44
LINK         ND2 ASN B 343                 C1  NAG B2001     1555   1555  1.45
LINK         O4  NAG A2002                 C1  NAG A2003     1555   1555  1.45
LINK         O4  NAG A2003                 C1  BMA A2004     1555   1555  1.45
LINK         ND2 ASN A 547                 C1  NAG A2002     1555   1555  1.45
LINK         O   VAL D 153                CA    CA D2001     1555   1555  2.09
LINK         O   ILE D 235                CA    CA D2001     1555   1555  2.30
LINK         OD1 ASN C 237                CA    CA C2001     1555   1555  2.31
LINK         O   VAL C 153                CA    CA C2001     1555   1555  2.38
LINK         OD1 ASN D 237                CA    CA D2001     1555   1555  2.39
LINK         OD2 ASP D 136                CA    CA D2001     1555   1555  2.45
LINK         OD2 ASP C 136                CA    CA C2001     1555   1555  2.49
LINK         O   ILE C 235                CA    CA C2001     1555   1555  2.75
CISPEP   1 GLN A  574    PRO A  575          0         0.09
CISPEP   2 GLN B  574    PRO B  575          0        -5.57
SITE     1 AC1  4 ASP C 136  VAL C 153  ILE C 235  ASN C 237
SITE     1 AC2  4 ASP D 136  VAL D 153  ILE D 235  ASN D 237
SITE     1 AC3  3 ARG A 334  THR A 338  ASN A 343
SITE     1 AC4  2 ASN A 547  NAG A2003
SITE     1 AC5  2 NAG A2002  BMA A2004
SITE     1 AC6  1 NAG A2003
SITE     1 AC7  3 ARG B 334  THR B 338  ASN B 343
CRYST1   81.261   95.186  120.396  90.00 108.62  90.00 P 1 21 1      4
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.012306  0.000000  0.004146        0.00000
SCALE2      0.000000  0.010506  0.000000        0.00000
SCALE3      0.000000  0.000000  0.008765        0.00000
TER    4400      HIS A 634
TER    8545      HIS B 634
TER    9900      GLY C 288
TER   11255      GLY D 288
MASTER      551    0    7   54   59    0    7    611320    4   94  118
END