longtext: 3W9B-pdb

content
HEADER    HYDROLASE                               02-APR-13   3W9B
TITLE     CRYSTAL STRUCTURE OF CANDIDA ANTARCTICA LIPASE B WITH ANION-TAG
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: LIPASE B;
COMPND   3 CHAIN: A, B, C, D;
COMPND   4 FRAGMENT: UNP RESIDUES 26-342;
COMPND   5 SYNONYM: CALB;
COMPND   6 EC: 3.1.1.3;
COMPND   7 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: CANDIDA ANTARCTICA;
SOURCE   3 ORGANISM_COMMON: YEAST;
SOURCE   4 ORGANISM_TAXID: 34362;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    LIPASE (CARBOXYLIC ESTERASE), HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    S.K.KIM,H.H.LEE,Y.C.PARK,S.T.JEON,S.H.SON,W.K.MIN,J.H.SEO
REVDAT   1   02-APR-14 3W9B    0
JRNL        AUTH   S.K.KIM,H.H.LEE,Y.C.PARK,S.T.JEON,S.H.SON,W.K.MIN,J.H.SEO
JRNL        TITL   ANION TAGS IMPROVE EXTRACELLULAR PRODUCTION OF CANDIDA
JRNL        TITL 2 ANTARCTICA LIPASE B IN ESCHERICHIA COLI
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    2.90 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.6.0117
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.90
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 19.80
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.6
REMARK   3   NUMBER OF REFLECTIONS             : 34806
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.234
REMARK   3   R VALUE            (WORKING SET) : 0.232
REMARK   3   FREE R VALUE                     : 0.265
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000
REMARK   3   FREE R VALUE TEST SET COUNT      : 1834
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.90
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.97
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 2490
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 100.00
REMARK   3   BIN R VALUE           (WORKING SET) : 0.3160
REMARK   3   BIN FREE R VALUE SET COUNT          : 117
REMARK   3   BIN FREE R VALUE                    : 0.3440
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 9292
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 88
REMARK   3   SOLVENT ATOMS            : 364
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 49.27
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : 0.00000
REMARK   3    B22 (A**2) : 0.00000
REMARK   3    B33 (A**2) : -0.00000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : -0.00000
REMARK   3    B23 (A**2) : -0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): NULL
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.415
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.306
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 31.377
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.901
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.856
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  9628 ; 0.007 ; 0.020
REMARK   3   BOND LENGTHS OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 13200 ; 1.057 ; 1.980
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  1264 ; 5.363 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   332 ;35.358 ;25.060
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  1360 ;15.418 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    32 ;15.929 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  1532 ; 0.058 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  7304 ; 0.006 ; 0.022
REMARK   3   GENERAL PLANES OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2):  NULL ;  NULL ;  NULL
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 4
REMARK   3
REMARK   3   TLS GROUP : 1
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A     1        A   317
REMARK   3    ORIGIN FOR THE GROUP (A):  12.4732  30.1162  -7.8780
REMARK   3    T TENSOR
REMARK   3      T11:   0.1011 T22:   0.1398
REMARK   3      T33:   0.1179 T12:   0.0944
REMARK   3      T13:   0.0227 T23:  -0.0238
REMARK   3    L TENSOR
REMARK   3      L11:   0.1160 L22:   0.3505
REMARK   3      L33:   0.5430 L12:  -0.1094
REMARK   3      L13:   0.1134 L23:   0.1519
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0794 S12:  -0.0831 S13:  -0.0417
REMARK   3      S21:  -0.0064 S22:   0.0390 S23:   0.0161
REMARK   3      S31:  -0.1429 S32:  -0.1640 S33:   0.0404
REMARK   3
REMARK   3   TLS GROUP : 2
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   B     1        B   317
REMARK   3    ORIGIN FOR THE GROUP (A):  44.0946  47.7876  -3.9966
REMARK   3    T TENSOR
REMARK   3      T11:   0.3034 T22:   0.0907
REMARK   3      T33:   0.0894 T12:  -0.0958
REMARK   3      T13:  -0.0778 T23:  -0.0035
REMARK   3    L TENSOR
REMARK   3      L11:   0.6024 L22:   0.0694
REMARK   3      L33:   0.2295 L12:  -0.0321
REMARK   3      L13:   0.2264 L23:   0.0569
REMARK   3    S TENSOR
REMARK   3      S11:  -0.1822 S12:   0.0110 S13:  -0.0067
REMARK   3      S21:  -0.0183 S22:   0.0851 S23:   0.0083
REMARK   3      S31:  -0.2278 S32:   0.0881 S33:   0.0971
REMARK   3
REMARK   3   TLS GROUP : 3
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   C     1        C   317
REMARK   3    ORIGIN FOR THE GROUP (A):  32.3300  -4.2540 -24.1160
REMARK   3    T TENSOR
REMARK   3      T11:   0.2103 T22:   0.0307
REMARK   3      T33:   0.1197 T12:   0.0291
REMARK   3      T13:   0.0103 T23:  -0.0347
REMARK   3    L TENSOR
REMARK   3      L11:   0.1674 L22:   0.2608
REMARK   3      L33:   0.5651 L12:  -0.1300
REMARK   3      L13:  -0.1602 L23:  -0.0918
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0310 S12:  -0.0375 S13:   0.0028
REMARK   3      S21:  -0.1114 S22:  -0.0051 S23:   0.0386
REMARK   3      S31:   0.2164 S32:   0.0406 S33:   0.0361
REMARK   3
REMARK   3   TLS GROUP : 4
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   D     1        D   317
REMARK   3    ORIGIN FOR THE GROUP (A):  63.4331  14.3082 -27.9764
REMARK   3    T TENSOR
REMARK   3      T11:   0.0718 T22:   0.3329
REMARK   3      T33:   0.0969 T12:   0.0482
REMARK   3      T13:   0.0372 T23:   0.0744
REMARK   3    L TENSOR
REMARK   3      L11:   0.2104 L22:   0.3457
REMARK   3      L33:   0.2007 L12:   0.1987
REMARK   3      L13:  -0.1632 L23:  -0.1312
REMARK   3    S TENSOR
REMARK   3      S11:   0.0178 S12:  -0.1455 S13:  -0.0099
REMARK   3      S21:  -0.0944 S22:  -0.1232 S23:   0.0132
REMARK   3      S31:   0.0295 S32:   0.2250 S33:   0.1054
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN USED IF PRESENT IN
REMARK   3  THE INPUT
REMARK   4
REMARK   4 3W9B COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 11-APR-13.
REMARK 100 THE RCSB ID CODE IS RCSB096048.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 25-APR-12
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 4.2
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : OTHER
REMARK 200  BEAMLINE                       : NULL
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9795
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 270
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 36843
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.900
REMARK 200  RESOLUTION RANGE LOW       (A) : 20.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : -3.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 100.0
REMARK 200  DATA REDUNDANCY                : NULL
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : NULL
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.90
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.95
REMARK 200  COMPLETENESS FOR SHELL     (%) : 100.0
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: 1TCA
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 60.18
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.09
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1M PHOSPHATE-CITRATE, 40% PEG600, PH
REMARK 280  4.2, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 297K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 65
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -Y,X-Y,Z+2/3
REMARK 290       3555   -X+Y,-X,Z+1/3
REMARK 290       4555   -X,-Y,Z+1/2
REMARK 290       5555   Y,-X+Y,Z+1/6
REMARK 290       6555   X-Y,X,Z+5/6
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -0.500000 -0.866025  0.000000        0.00000
REMARK 290   SMTRY2   2  0.866025 -0.500000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000      127.90133
REMARK 290   SMTRY1   3 -0.500000  0.866025  0.000000        0.00000
REMARK 290   SMTRY2   3 -0.866025 -0.500000  0.000000        0.00000
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000       63.95067
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   4  0.000000  0.000000  1.000000       95.92600
REMARK 290   SMTRY1   5  0.500000  0.866025  0.000000        0.00000
REMARK 290   SMTRY2   5 -0.866025  0.500000  0.000000        0.00000
REMARK 290   SMTRY3   5  0.000000  0.000000  1.000000       31.97533
REMARK 290   SMTRY1   6  0.500000 -0.866025  0.000000        0.00000
REMARK 290   SMTRY2   6  0.866025  0.500000  0.000000        0.00000
REMARK 290   SMTRY3   6  0.000000  0.000000  1.000000      159.87667
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 3960 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 21180 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -32.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 3950 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 21180 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -32.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A    -6
REMARK 465     ALA A    -5
REMARK 465     ASP A    -4
REMARK 465     ASP A    -3
REMARK 465     ASP A    -2
REMARK 465     ASP A    -1
REMARK 465     ASP A     0
REMARK 465     ILE A   318
REMARK 465     GLU A   319
REMARK 465     GLY A   320
REMARK 465     ARG A   321
REMARK 465     MET B    -6
REMARK 465     ALA B    -5
REMARK 465     ASP B    -4
REMARK 465     ASP B    -3
REMARK 465     ASP B    -2
REMARK 465     ASP B    -1
REMARK 465     ASP B     0
REMARK 465     ILE B   318
REMARK 465     GLU B   319
REMARK 465     GLY B   320
REMARK 465     ARG B   321
REMARK 465     MET C    -6
REMARK 465     ALA C    -5
REMARK 465     ASP C    -4
REMARK 465     ASP C    -3
REMARK 465     ASP C    -2
REMARK 465     ASP C    -1
REMARK 465     ASP C     0
REMARK 465     ILE C   318
REMARK 465     GLU C   319
REMARK 465     GLY C   320
REMARK 465     ARG C   321
REMARK 465     MET D    -6
REMARK 465     ALA D    -5
REMARK 465     ASP D    -4
REMARK 465     ASP D    -3
REMARK 465     ASP D    -2
REMARK 465     ASP D    -1
REMARK 465     ASP D     0
REMARK 465     ILE D   318
REMARK 465     GLU D   319
REMARK 465     GLY D   320
REMARK 465     ARG D   321
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    SER A  29       65.94   -164.13
REMARK 500    ASN A  51      -79.56   -139.88
REMARK 500    GLN A  58       -8.12    -58.65
REMARK 500    ASP A  75      125.48    -32.60
REMARK 500    ASN A  96       44.08     36.99
REMARK 500    SER A 105     -120.20     49.94
REMARK 500    ASP A 134       62.53   -115.05
REMARK 500    SER B   3     -157.35   -159.11
REMARK 500    ASN B  51      -68.53   -144.84
REMARK 500    ASP B  75      125.69    -34.21
REMARK 500    SER B 105     -130.08     49.77
REMARK 500    ALA B 132       49.80     35.39
REMARK 500    ASN B 206       -0.54     76.28
REMARK 500    VAL B 215      -36.07   -141.01
REMARK 500    PRO B 218       44.61    -77.34
REMARK 500    SER B 250      -15.01    -48.90
REMARK 500    SER C  29       73.76   -165.01
REMARK 500    ASN C  51      -82.95   -148.43
REMARK 500    ASP C  75      122.06    -32.78
REMARK 500    ASN C  96       43.05     37.32
REMARK 500    SER C 105     -119.48     48.28
REMARK 500    ASP C 134       62.47   -118.67
REMARK 500    LEU C 199        0.33    -69.68
REMARK 500    SER C 243      154.46    -48.08
REMARK 500    SER D   3     -153.66   -144.16
REMARK 500    ALA D  25     -105.58   -121.48
REMARK 500    ASN D  51      -80.27   -148.95
REMARK 500    ASP D  75      123.59    -32.35
REMARK 500    SER D 105     -128.24     50.79
REMARK 500    ALA D 132       49.56     34.82
REMARK 500    ASP D 134       67.85   -119.64
REMARK 500    VAL D 215      -53.90   -127.94
REMARK 500    PRO D 218       49.31    -83.17
REMARK 500    LEU D 219       -0.12   -144.66
REMARK 500    THR D 310     -164.35   -122.85
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH A1082        DISTANCE =  5.09 ANGSTROMS
REMARK 525    HOH A1092        DISTANCE =  7.76 ANGSTROMS
REMARK 525    HOH A1093        DISTANCE =  5.56 ANGSTROMS
REMARK 525    HOH B1073        DISTANCE =  5.04 ANGSTROMS
REMARK 610
REMARK 610 MISSING HETEROATOM
REMARK 610 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 610 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 610 I=INSERTION CODE):
REMARK 610   M RES C SSEQI
REMARK 610     PE8 B  901
REMARK 610     PE8 D  901
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PE8 A 901
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PE8 B 901
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PE8 C 901
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PE8 D 901
DBREF  3W9B A    1   317  UNP    P41365   LIPB_CANAR      26    342
DBREF  3W9B B    1   317  UNP    P41365   LIPB_CANAR      26    342
DBREF  3W9B C    1   317  UNP    P41365   LIPB_CANAR      26    342
DBREF  3W9B D    1   317  UNP    P41365   LIPB_CANAR      26    342
SEQADV 3W9B MET A   -6  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ALA A   -5  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ASP A   -4  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ASP A   -3  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ASP A   -2  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ASP A   -1  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ASP A    0  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ILE A  318  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B GLU A  319  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B GLY A  320  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ARG A  321  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B MET B   -6  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ALA B   -5  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ASP B   -4  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ASP B   -3  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ASP B   -2  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ASP B   -1  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ASP B    0  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ILE B  318  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B GLU B  319  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B GLY B  320  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ARG B  321  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B MET C   -6  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ALA C   -5  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ASP C   -4  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ASP C   -3  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ASP C   -2  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ASP C   -1  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ASP C    0  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ILE C  318  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B GLU C  319  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B GLY C  320  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ARG C  321  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B MET D   -6  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ALA D   -5  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ASP D   -4  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ASP D   -3  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ASP D   -2  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ASP D   -1  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ASP D    0  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ILE D  318  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B GLU D  319  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B GLY D  320  UNP  P41365              EXPRESSION TAG
SEQADV 3W9B ARG D  321  UNP  P41365              EXPRESSION TAG
SEQRES   1 A  328  MET ALA ASP ASP ASP ASP ASP LEU PRO SER GLY SER ASP
SEQRES   2 A  328  PRO ALA PHE SER GLN PRO LYS SER VAL LEU ASP ALA GLY
SEQRES   3 A  328  LEU THR CYS GLN GLY ALA SER PRO SER SER VAL SER LYS
SEQRES   4 A  328  PRO ILE LEU LEU VAL PRO GLY THR GLY THR THR GLY PRO
SEQRES   5 A  328  GLN SER PHE ASP SER ASN TRP ILE PRO LEU SER THR GLN
SEQRES   6 A  328  LEU GLY TYR THR PRO CYS TRP ILE SER PRO PRO PRO PHE
SEQRES   7 A  328  MET LEU ASN ASP THR GLN VAL ASN THR GLU TYR MET VAL
SEQRES   8 A  328  ASN ALA ILE THR ALA LEU TYR ALA GLY SER GLY ASN ASN
SEQRES   9 A  328  LYS LEU PRO VAL LEU THR TRP SER GLN GLY GLY LEU VAL
SEQRES  10 A  328  ALA GLN TRP GLY LEU THR PHE PHE PRO SER ILE ARG SER
SEQRES  11 A  328  LYS VAL ASP ARG LEU MET ALA PHE ALA PRO ASP TYR LYS
SEQRES  12 A  328  GLY THR VAL LEU ALA GLY PRO LEU ASP ALA LEU ALA VAL
SEQRES  13 A  328  SER ALA PRO SER VAL TRP GLN GLN THR THR GLY SER ALA
SEQRES  14 A  328  LEU THR THR ALA LEU ARG ASN ALA GLY GLY LEU THR GLN
SEQRES  15 A  328  ILE VAL PRO THR THR ASN LEU TYR SER ALA THR ASP GLU
SEQRES  16 A  328  ILE VAL GLN PRO GLN VAL SER ASN SER PRO LEU ASP SER
SEQRES  17 A  328  SER TYR LEU PHE ASN GLY LYS ASN VAL GLN ALA GLN ALA
SEQRES  18 A  328  VAL CYS GLY PRO LEU PHE VAL ILE ASP HIS ALA GLY SER
SEQRES  19 A  328  LEU THR SER GLN PHE SER TYR VAL VAL GLY ARG SER ALA
SEQRES  20 A  328  LEU ARG SER THR THR GLY GLN ALA ARG SER ALA ASP TYR
SEQRES  21 A  328  GLY ILE THR ASP CYS ASN PRO LEU PRO ALA ASN ASP LEU
SEQRES  22 A  328  THR PRO GLU GLN LYS VAL ALA ALA ALA ALA LEU LEU ALA
SEQRES  23 A  328  PRO ALA ALA ALA ALA ILE VAL ALA GLY PRO LYS GLN ASN
SEQRES  24 A  328  CYS GLU PRO ASP LEU MET PRO TYR ALA ARG PRO PHE ALA
SEQRES  25 A  328  VAL GLY LYS ARG THR CYS SER GLY ILE VAL THR PRO ILE
SEQRES  26 A  328  GLU GLY ARG
SEQRES   1 B  328  MET ALA ASP ASP ASP ASP ASP LEU PRO SER GLY SER ASP
SEQRES   2 B  328  PRO ALA PHE SER GLN PRO LYS SER VAL LEU ASP ALA GLY
SEQRES   3 B  328  LEU THR CYS GLN GLY ALA SER PRO SER SER VAL SER LYS
SEQRES   4 B  328  PRO ILE LEU LEU VAL PRO GLY THR GLY THR THR GLY PRO
SEQRES   5 B  328  GLN SER PHE ASP SER ASN TRP ILE PRO LEU SER THR GLN
SEQRES   6 B  328  LEU GLY TYR THR PRO CYS TRP ILE SER PRO PRO PRO PHE
SEQRES   7 B  328  MET LEU ASN ASP THR GLN VAL ASN THR GLU TYR MET VAL
SEQRES   8 B  328  ASN ALA ILE THR ALA LEU TYR ALA GLY SER GLY ASN ASN
SEQRES   9 B  328  LYS LEU PRO VAL LEU THR TRP SER GLN GLY GLY LEU VAL
SEQRES  10 B  328  ALA GLN TRP GLY LEU THR PHE PHE PRO SER ILE ARG SER
SEQRES  11 B  328  LYS VAL ASP ARG LEU MET ALA PHE ALA PRO ASP TYR LYS
SEQRES  12 B  328  GLY THR VAL LEU ALA GLY PRO LEU ASP ALA LEU ALA VAL
SEQRES  13 B  328  SER ALA PRO SER VAL TRP GLN GLN THR THR GLY SER ALA
SEQRES  14 B  328  LEU THR THR ALA LEU ARG ASN ALA GLY GLY LEU THR GLN
SEQRES  15 B  328  ILE VAL PRO THR THR ASN LEU TYR SER ALA THR ASP GLU
SEQRES  16 B  328  ILE VAL GLN PRO GLN VAL SER ASN SER PRO LEU ASP SER
SEQRES  17 B  328  SER TYR LEU PHE ASN GLY LYS ASN VAL GLN ALA GLN ALA
SEQRES  18 B  328  VAL CYS GLY PRO LEU PHE VAL ILE ASP HIS ALA GLY SER
SEQRES  19 B  328  LEU THR SER GLN PHE SER TYR VAL VAL GLY ARG SER ALA
SEQRES  20 B  328  LEU ARG SER THR THR GLY GLN ALA ARG SER ALA ASP TYR
SEQRES  21 B  328  GLY ILE THR ASP CYS ASN PRO LEU PRO ALA ASN ASP LEU
SEQRES  22 B  328  THR PRO GLU GLN LYS VAL ALA ALA ALA ALA LEU LEU ALA
SEQRES  23 B  328  PRO ALA ALA ALA ALA ILE VAL ALA GLY PRO LYS GLN ASN
SEQRES  24 B  328  CYS GLU PRO ASP LEU MET PRO TYR ALA ARG PRO PHE ALA
SEQRES  25 B  328  VAL GLY LYS ARG THR CYS SER GLY ILE VAL THR PRO ILE
SEQRES  26 B  328  GLU GLY ARG
SEQRES   1 C  328  MET ALA ASP ASP ASP ASP ASP LEU PRO SER GLY SER ASP
SEQRES   2 C  328  PRO ALA PHE SER GLN PRO LYS SER VAL LEU ASP ALA GLY
SEQRES   3 C  328  LEU THR CYS GLN GLY ALA SER PRO SER SER VAL SER LYS
SEQRES   4 C  328  PRO ILE LEU LEU VAL PRO GLY THR GLY THR THR GLY PRO
SEQRES   5 C  328  GLN SER PHE ASP SER ASN TRP ILE PRO LEU SER THR GLN
SEQRES   6 C  328  LEU GLY TYR THR PRO CYS TRP ILE SER PRO PRO PRO PHE
SEQRES   7 C  328  MET LEU ASN ASP THR GLN VAL ASN THR GLU TYR MET VAL
SEQRES   8 C  328  ASN ALA ILE THR ALA LEU TYR ALA GLY SER GLY ASN ASN
SEQRES   9 C  328  LYS LEU PRO VAL LEU THR TRP SER GLN GLY GLY LEU VAL
SEQRES  10 C  328  ALA GLN TRP GLY LEU THR PHE PHE PRO SER ILE ARG SER
SEQRES  11 C  328  LYS VAL ASP ARG LEU MET ALA PHE ALA PRO ASP TYR LYS
SEQRES  12 C  328  GLY THR VAL LEU ALA GLY PRO LEU ASP ALA LEU ALA VAL
SEQRES  13 C  328  SER ALA PRO SER VAL TRP GLN GLN THR THR GLY SER ALA
SEQRES  14 C  328  LEU THR THR ALA LEU ARG ASN ALA GLY GLY LEU THR GLN
SEQRES  15 C  328  ILE VAL PRO THR THR ASN LEU TYR SER ALA THR ASP GLU
SEQRES  16 C  328  ILE VAL GLN PRO GLN VAL SER ASN SER PRO LEU ASP SER
SEQRES  17 C  328  SER TYR LEU PHE ASN GLY LYS ASN VAL GLN ALA GLN ALA
SEQRES  18 C  328  VAL CYS GLY PRO LEU PHE VAL ILE ASP HIS ALA GLY SER
SEQRES  19 C  328  LEU THR SER GLN PHE SER TYR VAL VAL GLY ARG SER ALA
SEQRES  20 C  328  LEU ARG SER THR THR GLY GLN ALA ARG SER ALA ASP TYR
SEQRES  21 C  328  GLY ILE THR ASP CYS ASN PRO LEU PRO ALA ASN ASP LEU
SEQRES  22 C  328  THR PRO GLU GLN LYS VAL ALA ALA ALA ALA LEU LEU ALA
SEQRES  23 C  328  PRO ALA ALA ALA ALA ILE VAL ALA GLY PRO LYS GLN ASN
SEQRES  24 C  328  CYS GLU PRO ASP LEU MET PRO TYR ALA ARG PRO PHE ALA
SEQRES  25 C  328  VAL GLY LYS ARG THR CYS SER GLY ILE VAL THR PRO ILE
SEQRES  26 C  328  GLU GLY ARG
SEQRES   1 D  328  MET ALA ASP ASP ASP ASP ASP LEU PRO SER GLY SER ASP
SEQRES   2 D  328  PRO ALA PHE SER GLN PRO LYS SER VAL LEU ASP ALA GLY
SEQRES   3 D  328  LEU THR CYS GLN GLY ALA SER PRO SER SER VAL SER LYS
SEQRES   4 D  328  PRO ILE LEU LEU VAL PRO GLY THR GLY THR THR GLY PRO
SEQRES   5 D  328  GLN SER PHE ASP SER ASN TRP ILE PRO LEU SER THR GLN
SEQRES   6 D  328  LEU GLY TYR THR PRO CYS TRP ILE SER PRO PRO PRO PHE
SEQRES   7 D  328  MET LEU ASN ASP THR GLN VAL ASN THR GLU TYR MET VAL
SEQRES   8 D  328  ASN ALA ILE THR ALA LEU TYR ALA GLY SER GLY ASN ASN
SEQRES   9 D  328  LYS LEU PRO VAL LEU THR TRP SER GLN GLY GLY LEU VAL
SEQRES  10 D  328  ALA GLN TRP GLY LEU THR PHE PHE PRO SER ILE ARG SER
SEQRES  11 D  328  LYS VAL ASP ARG LEU MET ALA PHE ALA PRO ASP TYR LYS
SEQRES  12 D  328  GLY THR VAL LEU ALA GLY PRO LEU ASP ALA LEU ALA VAL
SEQRES  13 D  328  SER ALA PRO SER VAL TRP GLN GLN THR THR GLY SER ALA
SEQRES  14 D  328  LEU THR THR ALA LEU ARG ASN ALA GLY GLY LEU THR GLN
SEQRES  15 D  328  ILE VAL PRO THR THR ASN LEU TYR SER ALA THR ASP GLU
SEQRES  16 D  328  ILE VAL GLN PRO GLN VAL SER ASN SER PRO LEU ASP SER
SEQRES  17 D  328  SER TYR LEU PHE ASN GLY LYS ASN VAL GLN ALA GLN ALA
SEQRES  18 D  328  VAL CYS GLY PRO LEU PHE VAL ILE ASP HIS ALA GLY SER
SEQRES  19 D  328  LEU THR SER GLN PHE SER TYR VAL VAL GLY ARG SER ALA
SEQRES  20 D  328  LEU ARG SER THR THR GLY GLN ALA ARG SER ALA ASP TYR
SEQRES  21 D  328  GLY ILE THR ASP CYS ASN PRO LEU PRO ALA ASN ASP LEU
SEQRES  22 D  328  THR PRO GLU GLN LYS VAL ALA ALA ALA ALA LEU LEU ALA
SEQRES  23 D  328  PRO ALA ALA ALA ALA ILE VAL ALA GLY PRO LYS GLN ASN
SEQRES  24 D  328  CYS GLU PRO ASP LEU MET PRO TYR ALA ARG PRO PHE ALA
SEQRES  25 D  328  VAL GLY LYS ARG THR CYS SER GLY ILE VAL THR PRO ILE
SEQRES  26 D  328  GLU GLY ARG
HET    PE8  A 901      25
HET    PE8  B 901      19
HET    PE8  C 901      25
HET    PE8  D 901      19
HETNAM     PE8 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL
FORMUL   5  PE8    4(C16 H34 O9)
FORMUL   9  HOH   *364(H2 O)
HELIX    1   1 PRO A   12  ALA A   18  1                                   7
HELIX    2   2 THR A   43  ASP A   49  1                                   7
HELIX    3   3 ASN A   51  GLN A   58  1                                   8
HELIX    4   4 ASP A   75  SER A   94  1                                  20
HELIX    5   5 SER A  105  PHE A  118  1                                  14
HELIX    6   6 PRO A  119  ARG A  122  5                                   4
HELIX    7   7 THR A  138  LEU A  140  5                                   3
HELIX    8   8 ALA A  141  LEU A  147  1                                   7
HELIX    9   9 ALA A  151  GLN A  157  1                                   7
HELIX   10  10 SER A  161  ALA A  170  1                                  10
HELIX   11  11 GLN A  213  VAL A  215  5                                   3
HELIX   12  12 ALA A  225  SER A  230  1                                   6
HELIX   13  13 SER A  230  SER A  243  1                                  14
HELIX   14  14 GLY A  254  CYS A  258  5                                   5
HELIX   15  15 THR A  267  ALA A  276  1                                  10
HELIX   16  16 LEU A  277  GLY A  288  1                                  12
HELIX   17  17 ALA A  301  VAL A  306  5                                   6
HELIX   18  18 PRO B   12  ALA B   18  1                                   7
HELIX   19  19 THR B   43  ASP B   49  1                                   7
HELIX   20  20 ASN B   51  GLY B   60  1                                  10
HELIX   21  21 ASP B   75  GLY B   93  1                                  19
HELIX   22  22 SER B  105  PHE B  118  1                                  14
HELIX   23  23 PRO B  119  SER B  123  5                                   5
HELIX   24  24 ALA B  141  LEU B  147  1                                   7
HELIX   25  25 ALA B  151  GLN B  157  1                                   7
HELIX   26  26 SER B  161  ALA B  170  1                                  10
HELIX   27  27 ALA B  212  GLY B  217  1                                   6
HELIX   28  28 ALA B  225  SER B  230  1                                   6
HELIX   29  29 SER B  230  SER B  243  1                                  14
HELIX   30  30 GLY B  254  CYS B  258  5                                   5
HELIX   31  31 THR B  267  ALA B  276  1                                  10
HELIX   32  32 LEU B  277  GLY B  288  1                                  12
HELIX   33  33 ALA B  301  VAL B  306  5                                   6
HELIX   34  34 PRO C   12  ALA C   18  1                                   7
HELIX   35  35 THR C   43  ASP C   49  1                                   7
HELIX   36  36 ASN C   51  GLN C   58  1                                   8
HELIX   37  37 ASP C   75  SER C   94  1                                  20
HELIX   38  38 SER C  105  PHE C  118  1                                  14
HELIX   39  39 PRO C  119  ARG C  122  5                                   4
HELIX   40  40 THR C  138  LEU C  140  5                                   3
HELIX   41  41 ALA C  141  LEU C  147  1                                   7
HELIX   42  42 ALA C  151  GLN C  157  1                                   7
HELIX   43  43 SER C  161  ALA C  170  1                                  10
HELIX   44  44 GLN C  213  VAL C  215  5                                   3
HELIX   45  45 ALA C  225  SER C  230  1                                   6
HELIX   46  46 SER C  230  SER C  243  1                                  14
HELIX   47  47 ARG C  249  TYR C  253  5                                   5
HELIX   48  48 GLY C  254  CYS C  258  5                                   5
HELIX   49  49 THR C  267  ALA C  275  1                                   9
HELIX   50  50 LEU C  277  GLY C  288  1                                  12
HELIX   51  51 ALA C  301  VAL C  306  5                                   6
HELIX   52  52 PRO D   12  GLY D   19  1                                   8
HELIX   53  53 THR D   43  ASP D   49  1                                   7
HELIX   54  54 ILE D   53  GLN D   58  1                                   6
HELIX   55  55 ASP D   75  GLY D   93  1                                  19
HELIX   56  56 SER D  105  PHE D  118  1                                  14
HELIX   57  57 PRO D  119  SER D  123  5                                   5
HELIX   58  58 ALA D  141  LEU D  147  1                                   7
HELIX   59  59 ALA D  151  GLN D  157  1                                   7
HELIX   60  60 SER D  161  ALA D  170  1                                  10
HELIX   61  61 ALA D  212  GLY D  217  1                                   6
HELIX   62  62 SER D  230  SER D  243  1                                  14
HELIX   63  63 ARG D  249  TYR D  253  5                                   5
HELIX   64  64 GLY D  254  CYS D  258  5                                   5
HELIX   65  65 THR D  267  ALA D  276  1                                  10
HELIX   66  66 LEU D  277  GLY D  288  1                                  12
HELIX   67  67 ALA D  301  VAL D  306  5                                   6
SHEET    1   A 7 LEU A  20  CYS A  22  0
SHEET    2   A 7 THR A  62  ILE A  66 -1  O  TRP A  65   N  THR A  21
SHEET    3   A 7 PRO A  33  VAL A  37  1  N  ILE A  34   O  CYS A  64
SHEET    4   A 7 LEU A  99  TRP A 104  1  O  LEU A 102   N  LEU A  35
SHEET    5   A 7 VAL A 125  PHE A 131  1  O  MET A 129   N  VAL A 101
SHEET    6   A 7 THR A 179  TYR A 183  1  O  THR A 180   N  ALA A 130
SHEET    7   A 7 LYS A 208  GLN A 211  1  O  LYS A 208   N  ASN A 181
SHEET    1   B 2 ARG A 309  THR A 310  0
SHEET    2   B 2 GLY A 313  ILE A 314 -1  O  GLY A 313   N  THR A 310
SHEET    1   C 7 LEU B  20  CYS B  22  0
SHEET    2   C 7 THR B  62  ILE B  66 -1  O  TRP B  65   N  THR B  21
SHEET    3   C 7 PRO B  33  VAL B  37  1  N  ILE B  34   O  CYS B  64
SHEET    4   C 7 LEU B  99  TRP B 104  1  O  LEU B 102   N  LEU B  35
SHEET    5   C 7 VAL B 125  PHE B 131  1  O  MET B 129   N  VAL B 101
SHEET    6   C 7 THR B 179  TYR B 183  1  O  THR B 180   N  LEU B 128
SHEET    7   C 7 LYS B 208  GLN B 211  1  O  LYS B 208   N  ASN B 181
SHEET    1   D 2 ARG B 309  THR B 310  0
SHEET    2   D 2 GLY B 313  ILE B 314 -1  O  GLY B 313   N  THR B 310
SHEET    1   E 7 LEU C  20  CYS C  22  0
SHEET    2   E 7 THR C  62  ILE C  66 -1  O  TRP C  65   N  THR C  21
SHEET    3   E 7 PRO C  33  VAL C  37  1  N  ILE C  34   O  CYS C  64
SHEET    4   E 7 LEU C  99  TRP C 104  1  O  LEU C 102   N  LEU C  35
SHEET    5   E 7 VAL C 125  PHE C 131  1  O  MET C 129   N  VAL C 101
SHEET    6   E 7 THR C 179  TYR C 183  1  O  THR C 180   N  ALA C 130
SHEET    7   E 7 LYS C 208  GLN C 211  1  O  LYS C 208   N  ASN C 181
SHEET    1   F 2 ARG C 309  THR C 310  0
SHEET    2   F 2 GLY C 313  ILE C 314 -1  O  GLY C 313   N  THR C 310
SHEET    1   G 7 LEU D  20  CYS D  22  0
SHEET    2   G 7 THR D  62  ILE D  66 -1  O  TRP D  65   N  THR D  21
SHEET    3   G 7 PRO D  33  VAL D  37  1  N  ILE D  34   O  CYS D  64
SHEET    4   G 7 LEU D  99  TRP D 104  1  O  LEU D 102   N  LEU D  35
SHEET    5   G 7 VAL D 125  PHE D 131  1  O  MET D 129   N  VAL D 101
SHEET    6   G 7 THR D 179  TYR D 183  1  O  THR D 180   N  LEU D 128
SHEET    7   G 7 LYS D 208  GLN D 211  1  O  LYS D 208   N  ASN D 181
SHEET    1   H 2 ARG D 309  THR D 310  0
SHEET    2   H 2 GLY D 313  ILE D 314 -1  O  GLY D 313   N  THR D 310
SSBOND   1 CYS A   22    CYS A   64                          1555   1555  2.04
SSBOND   2 CYS A  216    CYS A  258                          1555   1555  2.04
SSBOND   3 CYS A  293    CYS A  311                          1555   1555  2.05
SSBOND   4 CYS B   22    CYS B   64                          1555   1555  2.04
SSBOND   5 CYS B  216    CYS B  258                          1555   1555  2.04
SSBOND   6 CYS B  293    CYS B  311                          1555   1555  2.06
SSBOND   7 CYS C   22    CYS C   64                          1555   1555  2.04
SSBOND   8 CYS C  216    CYS C  258                          1555   1555  2.04
SSBOND   9 CYS C  293    CYS C  311                          1555   1555  2.05
SSBOND  10 CYS D   22    CYS D   64                          1555   1555  2.04
SSBOND  11 CYS D  216    CYS D  258                          1555   1555  2.04
SSBOND  12 CYS D  293    CYS D  311                          1555   1555  2.05
CISPEP   1 PRO A   69    PRO A   70          0        -0.16
CISPEP   2 GLN A  191    PRO A  192          0         4.35
CISPEP   3 PRO B   69    PRO B   70          0        -9.66
CISPEP   4 GLN B  191    PRO B  192          0         6.34
CISPEP   5 PRO C   69    PRO C   70          0        -0.83
CISPEP   6 GLN C  191    PRO C  192          0         6.13
CISPEP   7 LEU D    1    PRO D    2          0       -16.10
CISPEP   8 PRO D   69    PRO D   70          0       -11.14
CISPEP   9 GLN D  191    PRO D  192          0         5.83
SITE     1 AC1  8 GLN A 157  ILE A 189  THR B  40  GLN B 157
SITE     2 AC1  8 GLU B 188  ILE B 189  ALA B 282  PE8 B 901
SITE     1 AC2  9 THR A  40  SER A 105  ALA A 282  ILE A 285
SITE     2 AC2  9 PE8 A 901  THR B  40  SER B 105  ALA B 282
SITE     3 AC2  9 ILE B 285
SITE     1 AC3  9 THR C  40  GLN C 157  ILE C 189  THR D  40
SITE     2 AC3  9 SER D 105  GLN D 157  GLU D 188  ILE D 189
SITE     3 AC3  9 PE8 D 901
SITE     1 AC4  9 THR C  40  SER C 105  ALA C 282  ILE C 285
SITE     2 AC4  9 PE8 C 901  THR D  40  SER D 105  ALA D 282
SITE     3 AC4  9 ILE D 285
CRYST1  123.659  123.659  191.852  90.00  90.00 120.00 P 65         24
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.008087  0.004669  0.000000        0.00000
SCALE2      0.000000  0.009338  0.000000        0.00000
SCALE3      0.000000  0.000000  0.005212        0.00000
TER    2324      PRO A 317
TER    4648      PRO B 317
TER    6972      PRO C 317
TER    9296      PRO D 317
MASTER      474    0    4   67   36    0   11    6 9744    4  112  104
END