longtext: 3WWE-pdb

content
HEADER    HYDROLASE                               17-JUN-14   3WWE
TITLE     THE COMPLEX OF POPH WITH PEG
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: OXIDIZED POLYVINYL ALCOHOL HYDROLASE;
COMPND   3 CHAIN: A;
COMPND   4 FRAGMENT: UNP RESIDUES 30-379;
COMPND   5 SYNONYM: OPH, OXIDIZED PVA HYDROLASE, BETA-DIKETONE HYDROLASE;
COMPND   6 EC: 3.7.1.7;
COMPND   7 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: PSEUDOMONAS SP. VM15C;
SOURCE   3 ORGANISM_TAXID: 237605;
SOURCE   4 GENE: PVAB;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE   7 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE   8 EXPRESSION_SYSTEM_PLASMID: PET32A
KEYWDS    TRYPTOPHAN, DISULFIDE BRIDGE, P-NITROPHENYL ESTERS, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    Y.YANG,T.P.KO,J.H.LI,L.LIU,C.H.HUANG,J.CHEN,R.T.GUO,G.C.DU
REVDAT   1   29-APR-15 3WWE    0
JRNL        AUTH   Y.YANG,T.P.KO,L.LIU,J.LI,C.H.HUANG,J.CHEN,R.T.GUO,G.DU
JRNL        TITL   ROLES OF TRYPTOPHAN RESIDUE AND DISULFIDE BOND IN THE
JRNL        TITL 2 VARIABLE LID REGION OF OXIDIZED POLYVINYL ALCOHOL HYDROLASE
JRNL        REF    BIOCHEM.BIOPHYS.RES.COMMUN.   V. 452   509 2014
JRNL        REFN                   ISSN 0006-291X
JRNL        PMID   25173935
JRNL        DOI    10.1016/J.BBRC.2014.08.106
REMARK   2
REMARK   2 RESOLUTION.    2.10 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : CNS 1.21
REMARK   3   AUTHORS     : BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE-
REMARK   3               : KUNSTLEVE,JIANG,KUSZEWSKI,NILGES,PANNU,
REMARK   3               : READ,RICE,SIMONSON,WARREN
REMARK   3
REMARK   3  REFINEMENT TARGET : ENGH & HUBER
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.10
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 25.00
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000
REMARK   3   DATA CUTOFF HIGH         (ABS(F)) : NULL
REMARK   3   DATA CUTOFF LOW          (ABS(F)) : NULL
REMARK   3   COMPLETENESS (WORKING+TEST)   (%) : NULL
REMARK   3   NUMBER OF REFLECTIONS             : 18268
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : NULL
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE            (WORKING SET) : 0.159
REMARK   3   FREE R VALUE                     : 0.208
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : NULL
REMARK   3   FREE R VALUE TEST SET COUNT      : 891
REMARK   3   ESTIMATED ERROR OF FREE R VALUE  : NULL
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : NULL
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.10
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.18
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : NULL
REMARK   3   REFLECTIONS IN BIN    (WORKING SET) : NULL
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2710
REMARK   3   BIN FREE R VALUE                    : 0.2650
REMARK   3   BIN FREE R VALUE TEST SET SIZE  (%) : NULL
REMARK   3   BIN FREE R VALUE TEST SET COUNT     : 83
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE : NULL
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 2569
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 9
REMARK   3   SOLVENT ATOMS            : 405
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 25.43
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -2.50800
REMARK   3    B22 (A**2) : -5.51700
REMARK   3    B33 (A**2) : 8.02500
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : -0.00000
REMARK   3    B23 (A**2) : -0.00000
REMARK   3
REMARK   3  ESTIMATED COORDINATE ERROR.
REMARK   3   ESD FROM LUZZATI PLOT        (A) : 0.29
REMARK   3   ESD FROM SIGMAA              (A) : 0.25
REMARK   3   LOW RESOLUTION CUTOFF        (A) : 5.00
REMARK   3
REMARK   3  CROSS-VALIDATED ESTIMATED COORDINATE ERROR.
REMARK   3   ESD FROM C-V LUZZATI PLOT    (A) : 0.29
REMARK   3   ESD FROM C-V SIGMAA          (A) : 0.18
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES.
REMARK   3   BOND LENGTHS                 (A) : NULL
REMARK   3   BOND ANGLES            (DEGREES) : 1.850
REMARK   3   DIHEDRAL ANGLES        (DEGREES) : NULL
REMARK   3   IMPROPER ANGLES        (DEGREES) : NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL MODEL : NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.    RMS    SIGMA
REMARK   3   MAIN-CHAIN BOND              (A**2) : 1.319 ; 1.500
REMARK   3   MAIN-CHAIN ANGLE             (A**2) : 1.940 ; 2.000
REMARK   3   SIDE-CHAIN BOND              (A**2) : 2.281 ; 2.000
REMARK   3   SIDE-CHAIN ANGLE             (A**2) : 3.073 ; 2.500
REMARK   3
REMARK   3  BULK SOLVENT MODELING.
REMARK   3   METHOD USED : NULL
REMARK   3   KSOL        : NULL
REMARK   3   BSOL        : 32.05
REMARK   3
REMARK   3  NCS MODEL : NULL
REMARK   3
REMARK   3  NCS RESTRAINTS.                         RMS   SIGMA/WEIGHT
REMARK   3   GROUP  1  POSITIONAL            (A) : NULL  ; NULL
REMARK   3   GROUP  1  B-FACTOR           (A**2) : NULL  ; NULL
REMARK   3
REMARK   3  PARAMETER FILE  1  : CNS_TOPPAR:PROTEIN_REP.PARAM
REMARK   3  PARAMETER FILE  2  : CNS_TOPPAR:WATER_REP.PARAM
REMARK   3  PARAMETER FILE  3  : CNS_TOPPAR:ION.PARAM
REMARK   3  PARAMETER FILE  4  : PEG_XPLOR.PARAM
REMARK   3  PARAMETER FILE  5  : NULL
REMARK   3  TOPOLOGY FILE  1   : NULL
REMARK   3  TOPOLOGY FILE  2   : NULL
REMARK   3  TOPOLOGY FILE  3   : NULL
REMARK   3  TOPOLOGY FILE  4   : NULL
REMARK   3  TOPOLOGY FILE  5   : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 3WWE COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 04-JUL-14.
REMARK 100 THE RCSB ID CODE IS RCSB096876.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 04-APR-13
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 6.5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : NSRRC
REMARK 200  BEAMLINE                       : BL13B1
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1
REMARK 200  MONOCHROMATOR                  : SI 111 CHANNEL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 315
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 19106
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.100
REMARK 200  RESOLUTION RANGE LOW       (A) : 25.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 3.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 97.6
REMARK 200  DATA REDUNDANCY                : 6.100
REMARK 200  R MERGE                    (I) : 0.07800
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 25.5000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.10
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.18
REMARK 200  COMPLETENESS FOR SHELL     (%) : 86.1
REMARK 200  DATA REDUNDANCY IN SHELL       : 3.90
REMARK 200  R MERGE FOR SHELL          (I) : 0.26700
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 4.300
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: PDB ENTRY 3WL6
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 40.16
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.06
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 30% PEG MME 5000, MES PH 6.5, 0.2M
REMARK 280  (NH4)2SO4, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 295K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X+1/2,-Y,Z+1/2
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       29.19600
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       42.22300
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       32.73450
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       42.22300
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       29.19600
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       32.73450
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     ALA A    -4
REMARK 465     GLY A    -3
REMARK 465     ALA A    -2
REMARK 465     GLY A    -1
REMARK 465     ALA A     0
REMARK 465     ASP A     1
REMARK 465     ARG A     2
REMARK 465     THR A     3
REMARK 465     ALA A     4
REMARK 465     ALA A     5
REMARK 465     THR A     6
REMARK 465     PRO A     7
REMARK 465     ALA A     8
REMARK 465     ALA A     9
REMARK 465     ALA A    10
REMARK 465     ASN A    11
REMARK 465     PRO A    12
REMARK 465     ALA A    13
REMARK 465     ALA A    14
REMARK 465     THR A    15
REMARK 465     GLU A    16
REMARK 465     PRO A    17
REMARK 465     VAL A    18
REMARK 465     HIS A   354
REMARK 465     PRO A   355
REMARK 465     GLN A   356
REMARK 465     PHE A   357
REMARK 465     GLU A   358
REMARK 465     LYS A   359
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     SER A 353    OG
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    LEU A 168   CA  -  CB  -  CG  ANGL. DEV. =  15.4 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ALA A  81       54.87     35.22
REMARK 500    ARG A 107     -101.93   -105.62
REMARK 500    ARG A 165       51.95   -142.20
REMARK 500    SER A 172     -121.75     58.49
REMARK 500    PHE A 188      -62.77   -109.23
REMARK 500    ALA A 221       62.54   -152.32
REMARK 500    ASP A 261        3.44    -69.79
REMARK 500    MET A 299      178.66    179.38
REMARK 500    PRO A 301      123.31    -34.82
REMARK 500    TRP A 352       17.91    -63.26
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: PLANAR GROUPS
REMARK 500
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS
REMARK 500 AN RMSD GREATER THAN THIS VALUE
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500  M RES CSSEQI        RMS     TYPE
REMARK 500    TYR A 233         0.06    SIDE CHAIN
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CHIRAL CENTERS
REMARK 500
REMARK 500 UNEXPECTED CONFIGURATION OF THE FOLLOWING CHIRAL
REMARK 500 CENTER(S) USING IMPROPER CA--C--CB--N CHIRALITY
REMARK 500 FOR AMINO ACIDS AND C1'--O4'--N1(N9)--C2' FOR
REMARK 500 NUCLEIC ACIDS OR EQUIVALENT ANGLE
REMARK 500 M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,6X,F5.1,6X,A1,10X,A1,3X,A16)
REMARK 500
REMARK 500  M RES CSSEQI    IMPROPER   EXPECTED   FOUND DETAILS
REMARK 500    ASN A 122        24.3      L          L   OUTSIDE RANGE
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH A1102        DISTANCE =  5.49 ANGSTROMS
REMARK 525    HOH A1141        DISTANCE =  6.14 ANGSTROMS
REMARK 525    HOH A1161        DISTANCE =  7.01 ANGSTROMS
REMARK 525    HOH A1192        DISTANCE =  5.52 ANGSTROMS
REMARK 525    HOH A1218        DISTANCE =  7.14 ANGSTROMS
REMARK 525    HOH A1232        DISTANCE =  5.84 ANGSTROMS
REMARK 525    HOH A1233        DISTANCE =  7.03 ANGSTROMS
REMARK 525    HOH A1241        DISTANCE =  5.26 ANGSTROMS
REMARK 525    HOH A1259        DISTANCE =  5.43 ANGSTROMS
REMARK 525    HOH A1265        DISTANCE =  5.36 ANGSTROMS
REMARK 525    HOH A1272        DISTANCE =  6.55 ANGSTROMS
REMARK 525    HOH A1274        DISTANCE =  5.42 ANGSTROMS
REMARK 525    HOH A1314        DISTANCE =  7.14 ANGSTROMS
REMARK 525    HOH A1319        DISTANCE =  7.44 ANGSTROMS
REMARK 525    HOH A1322        DISTANCE =  8.01 ANGSTROMS
REMARK 525    HOH A1324        DISTANCE =  8.18 ANGSTROMS
REMARK 525    HOH A1327        DISTANCE =  7.39 ANGSTROMS
REMARK 525    HOH A1338        DISTANCE =  7.72 ANGSTROMS
REMARK 525    HOH A1339        DISTANCE =  5.80 ANGSTROMS
REMARK 525    HOH A1347        DISTANCE =  6.70 ANGSTROMS
REMARK 525    HOH A1352        DISTANCE =  6.59 ANGSTROMS
REMARK 525    HOH A1355        DISTANCE =  5.98 ANGSTROMS
REMARK 525    HOH A1357        DISTANCE =  9.85 ANGSTROMS
REMARK 525    HOH A1363        DISTANCE =  7.64 ANGSTROMS
REMARK 525    HOH A1383        DISTANCE =  7.75 ANGSTROMS
REMARK 525    HOH A1387        DISTANCE =  5.78 ANGSTROMS
REMARK 525    HOH A1389        DISTANCE =  7.37 ANGSTROMS
REMARK 525    HOH A1392        DISTANCE =  7.23 ANGSTROMS
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE AE3 A 900
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 3WWC   RELATED DB: PDB
REMARK 900 RELATED ID: 3WWD   RELATED DB: PDB
DBREF  3WWE A   -1   348  UNP    Q9LCQ7   OPH_PSESP       30    379
SEQADV 3WWE ALA A   -4  UNP  Q9LCQ7              EXPRESSION TAG
SEQADV 3WWE GLY A   -3  UNP  Q9LCQ7              EXPRESSION TAG
SEQADV 3WWE ALA A   -2  UNP  Q9LCQ7              EXPRESSION TAG
SEQADV 3WWE ALA A  349  UNP  Q9LCQ7              EXPRESSION TAG
SEQADV 3WWE SER A  350  UNP  Q9LCQ7              EXPRESSION TAG
SEQADV 3WWE ALA A  351  UNP  Q9LCQ7              EXPRESSION TAG
SEQADV 3WWE TRP A  352  UNP  Q9LCQ7              EXPRESSION TAG
SEQADV 3WWE SER A  353  UNP  Q9LCQ7              EXPRESSION TAG
SEQADV 3WWE HIS A  354  UNP  Q9LCQ7              EXPRESSION TAG
SEQADV 3WWE PRO A  355  UNP  Q9LCQ7              EXPRESSION TAG
SEQADV 3WWE GLN A  356  UNP  Q9LCQ7              EXPRESSION TAG
SEQADV 3WWE PHE A  357  UNP  Q9LCQ7              EXPRESSION TAG
SEQADV 3WWE GLU A  358  UNP  Q9LCQ7              EXPRESSION TAG
SEQADV 3WWE LYS A  359  UNP  Q9LCQ7              EXPRESSION TAG
SEQRES   1 A  364  ALA GLY ALA GLY ALA ASP ARG THR ALA ALA THR PRO ALA
SEQRES   2 A  364  ALA ALA ASN PRO ALA ALA THR GLU PRO VAL LYS TRP GLU
SEQRES   3 A  364  CYS PRO ALA GLY TYR GLU VAL LYS GLU GLY LEU ASN VAL
SEQRES   4 A  364  ASP PHE PRO HIS LYS GLY MET LYS ARG ALA PHE ILE VAL
SEQRES   5 A  364  TYR PRO ALA LYS ASN VAL SER GLY PRO ALA PRO VAL TRP
SEQRES   6 A  364  VAL PRO MET THR GLY SER VAL GLU SER THR ASN ASP ASN
SEQRES   7 A  364  LEU THR VAL ALA ARG SER GLY ALA ASN SER ILE LEU ALA
SEQRES   8 A  364  ASP HIS GLY TYR THR VAL ILE ALA PRO VAL ARG ALA CYS
SEQRES   9 A  364  ALA ASN GLN ASP PRO ASN ILE ARG GLY GLU ARG CYS ASN
SEQRES  10 A  364  GLY PRO GLY SER ASN GLY TRP ASN TRP ASN PRO TRP PHE
SEQRES  11 A  364  GLU GLY ARG ALA ALA ASP PRO SER GLY GLU HIS TRP LYS
SEQRES  12 A  364  ASN ASP GLU GLY PRO ASP SER SER PHE PHE VAL ALA MET
SEQRES  13 A  364  VAL GLN CYS VAL GLY THR LYS TYR LYS LEU ASP ALA ARG
SEQRES  14 A  364  ARG LEU PHE LEU GLY GLY ILE SER SER GLY GLY THR MET
SEQRES  15 A  364  THR ASN ARG ALA LEU LEU PHE ARG SER ASN PHE TRP ALA
SEQRES  16 A  364  GLY GLY LEU PRO ILE SER GLY GLU TRP TYR VAL THR SER
SEQRES  17 A  364  ASP ASP GLY THR PRO LEU SER PHE ASP ASP ALA ARG ALA
SEQRES  18 A  364  ALA VAL ALA ALA ALA PRO THR LYS ILE HIS GLN GLY ARG
SEQRES  19 A  364  VAL GLY PRO TYR PRO LEU PRO ALA LYS VAL GLY PRO LEU
SEQRES  20 A  364  ILE VAL MET THR VAL TRP GLY GLY GLU LYS ASP LEU TRP
SEQRES  21 A  364  ASN CYS THR ARG PRO ASP GLY SER ARG PHE LEU CYS ALA
SEQRES  22 A  364  ASP TYR ARG PRO SER THR GLN ALA GLY SER ASN PHE PHE
SEQRES  23 A  364  SER ALA GLN PRO ASP VAL VAL HIS VAL ALA CYS SER SER
SEQRES  24 A  364  THR HIS GLY HIS MET TRP PRO GLN LEU ASN THR GLN GLU
SEQRES  25 A  364  PHE ASN ARG TRP ALA LEU ASP THR LEU ALA SER HIS PRO
SEQRES  26 A  364  LYS GLY SER ASP PRO ARG SER PHE LYS LEU THR GLN PRO
SEQRES  27 A  364  PRO GLU GLY TYR THR CYS HIS VAL GLY PRO PHE THR GLY
SEQRES  28 A  364  LEU TYR ALA SER ALA TRP SER HIS PRO GLN PHE GLU LYS
HET    AE3  A 900       9
HETNAM     AE3 2-(2-ETHOXYETHOXY)ETHANOL
FORMUL   2  AE3    C6 H14 O3
FORMUL   3  HOH   *405(H2 O)
HELIX    1   1 SER A   69  VAL A   76  1                                   8
HELIX    2   2 ALA A   77  GLY A   80  5                                   4
HELIX    3   3 ALA A   81  ASP A   87  5                                   7
HELIX    4   4 ARG A   97  ASN A  101  5                                   5
HELIX    5   5 ASP A  131  ASN A  139  5                                   9
HELIX    6   6 GLY A  142  GLY A  156  1                                  15
HELIX    7   7 SER A  172  ARG A  185  1                                  14
HELIX    8   8 SER A  210  ALA A  221  1                                  12
HELIX    9   9 TYR A  270  GLN A  284  1                                  15
HELIX   10  10 ASN A  304  SER A  318  1                                  15
HELIX   11  11 ASP A  324  PHE A  328  5                                   5
SHEET    1   A 9 GLY A  31  HIS A  38  0
SHEET    2   A 9 MET A  41  TYR A  48 -1  O  PHE A  45   N  ASN A  33
SHEET    3   A 9 THR A  91  PRO A  95 -1  O  ALA A  94   N  ILE A  46
SHEET    4   A 9 ALA A  57  MET A  63  1  N  TRP A  60   O  ILE A  93
SHEET    5   A 9 LEU A 161  ILE A 171  1  O  ASP A 162   N  ALA A  57
SHEET    6   A 9 GLY A 191  ILE A 195  1  O  ILE A 195   N  GLY A 170
SHEET    7   A 9 LEU A 242  TRP A 248  1  O  MET A 245   N  GLY A 192
SHEET    8   A 9 VAL A 287  SER A 293  1  O  VAL A 290   N  VAL A 244
SHEET    9   A 9 THR A 338  VAL A 341 -1  O  HIS A 340   N  ALA A 291
SHEET    1   B 2 LEU A 254  THR A 258  0
SHEET    2   B 2 ARG A 264  ASP A 269 -1  O  CYS A 267   N  TRP A 255
SSBOND   1 CYS A   22    CYS A  154                          1555   1555  2.58
SSBOND   2 CYS A   99    CYS A  111                          1555   1555  2.33
SSBOND   3 CYS A  257    CYS A  267                          1555   1555  2.42
SSBOND   4 CYS A  292    CYS A  339                          1555   1555  2.36
CISPEP   1 TYR A  233    PRO A  234          0         0.14
SITE     1 AC1  9 ASN A 120  TRP A 121  SER A 172  SER A 173
SITE     2 AC1  9 TYR A 270  HOH A1029  HOH A1113  HOH A1205
SITE     3 AC1  9 HOH A1249
CRYST1   58.392   65.469   84.446  90.00  90.00  90.00 P 21 21 21    4
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.017126  0.000000  0.000000        0.00000
SCALE2      0.000000  0.015274  0.000000        0.00000
SCALE3      0.000000  0.000000  0.011842        0.00000
TER    2570      SER A 353
MASTER      390    0    1   11   11    0    3    6 2983    1   17   28
END