longtext: 3ZPX-pdb

content
HEADER    HYDROLASE                               04-MAR-13   3ZPX
TITLE     USTILAGO MAYDIS LIPASE UM03410, SHORT FORM WITHOUT FLAP
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: LIPASE;
COMPND   3 CHAIN: A, B;
COMPND   4 FRAGMENT: SHORT PROTEIN FORM, RESIDUES 152-582;
COMPND   5 EC: 3.1.1.3;
COMPND   6 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: USTILAGO MAYDIS;
SOURCE   3 ORGANISM_TAXID: 5270;
SOURCE   4 EXPRESSION_SYSTEM: KOMAGATAELLA PASTORIS;
SOURCE   5 EXPRESSION_SYSTEM_TAXID: 4922
KEYWDS    HYDROLASE, ALPHA BETA HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    G.J.PALM,W.HINRICHS
REVDAT   1   19-MAR-14 3ZPX    0
JRNL        AUTH   H.BRUNDIEK,G.J.PALM,U.T.BORNSCHEUER,W.HINRICHS
JRNL        TITL   LIPASE FROM USTILAGO
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   1
REMARK   1 REFERENCE 1
REMARK   1  AUTH   H.BRUNDIEK,S.SASS,A.EVITT,R.KOURIST,U.T.BORNSCHEUER
REMARK   1  TITL   THE SHORT FORM OF THE RECOMBINANT CAL-A-TYPE LIPASE UM03410
REMARK   1  TITL 2 FROM THE SMUT FUNGUS USTILAGO MAYDIS EXHIBITS AN INHERENT
REMARK   1  TITL 3 TRANS-FATTY ACID SELECTIVITY.
REMARK   1  REF    APPL.MICROBIOL.BIOTECHNOL.    V.  94   141 2012
REMARK   1  REFN                   ISSN 0175-7598
REMARK   1  PMID   22294433
REMARK   1  DOI    10.1007/S00253-012-3903-9
REMARK   2
REMARK   2 RESOLUTION.    1.99 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.7.0029
REMARK   3   AUTHORS     : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,
REMARK   3                 STEINER,NICHOLLS,WINN,LONG,VAGIN
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.99
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 39.57
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NONE
REMARK   3   COMPLETENESS FOR RANGE        (%) : 95.62
REMARK   3   NUMBER OF REFLECTIONS             : 45105
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.18539
REMARK   3   R VALUE            (WORKING SET) : 0.18283
REMARK   3   FREE R VALUE                     : 0.23469
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.0
REMARK   3   FREE R VALUE TEST SET COUNT      : 2373
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 1.989
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.040
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 2829
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 81.90
REMARK   3   BIN R VALUE           (WORKING SET) : 0.253
REMARK   3   BIN FREE R VALUE SET COUNT          : 149
REMARK   3   BIN FREE R VALUE                    : 0.302
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 5967
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 28
REMARK   3   SOLVENT ATOMS            : 319
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 32.0
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 27.209
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -1.40
REMARK   3    B22 (A**2) : 1.06
REMARK   3    B33 (A**2) : 0.33
REMARK   3    B12 (A**2) : 0.00
REMARK   3    B13 (A**2) : 0.00
REMARK   3    B23 (A**2) : 0.00
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.212
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.180
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.119
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 9.545
REMARK   3
REMARK   3  CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.946
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.917
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  6162 ; 0.008 ; 0.019
REMARK   3   BOND LENGTHS OTHERS               (A):  5703 ; 0.001 ; 0.020
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES):  8404 ; 1.241 ; 1.948
REMARK   3   BOND ANGLES OTHERS          (DEGREES): 13131 ; 0.774 ; 3.001
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):   780 ; 5.786 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   277 ;32.728 ;24.910
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):   921 ;14.196 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    18 ;13.909 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):   908 ; 0.073 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  7152 ; 0.005 ; 0.021
REMARK   3   GENERAL PLANES OTHERS             (A):  1444 ; 0.001 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ANISOTROPIC THERMAL FACTOR RESTRAINTS.   COUNT   RMS    WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 2
REMARK   3
REMARK   3   TLS GROUP : 1
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A    14        A   395
REMARK   3    ORIGIN FOR THE GROUP (A):  -4.9910  19.2500 -30.4670
REMARK   3    T TENSOR
REMARK   3      T11:   0.0411 T22:   0.0918
REMARK   3      T33:   0.0058 T12:   0.0206
REMARK   3      T13:   0.0107 T23:   0.0199
REMARK   3    L TENSOR
REMARK   3      L11:   1.0249 L22:   1.0202
REMARK   3      L33:   0.8502 L12:  -0.1599
REMARK   3      L13:   0.2243 L23:  -0.3982
REMARK   3    S TENSOR
REMARK   3      S11:   0.0173 S12:   0.1130 S13:   0.0214
REMARK   3      S21:   0.1132 S22:  -0.0359 S23:   0.0285
REMARK   3      S31:  -0.0157 S32:   0.1690 S33:   0.0186
REMARK   3
REMARK   3   TLS GROUP : 2
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   B    14        B   395
REMARK   3    ORIGIN FOR THE GROUP (A):   1.9610  -2.2770  -1.9830
REMARK   3    T TENSOR
REMARK   3      T11:   0.0597 T22:   0.0179
REMARK   3      T33:   0.0175 T12:   0.0054
REMARK   3      T13:  -0.0178 T23:   0.0090
REMARK   3    L TENSOR
REMARK   3      L11:   0.7732 L22:   0.4597
REMARK   3      L33:   1.6097 L12:  -0.0398
REMARK   3      L13:   0.3167 L23:  -0.0800
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0576 S12:  -0.0624 S13:  -0.0004
REMARK   3      S21:   0.0449 S22:  -0.0259 S23:   0.0034
REMARK   3      S31:  -0.2001 S32:  -0.0401 S33:   0.0834
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.70
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE
REMARK   3   RIDING POSITIONS.  U VALUES WITH TLS ADDED. OVERALL
REMARK   3   WEIGHTING TERM 0.1. B-FACTOR WEIGHT 0.5.
REMARK   4
REMARK   4 3ZPX COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 04-MAR-13.
REMARK 100 THE PDBE ID CODE IS EBI-56027.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 29-APR-11
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 4.5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : BESSY
REMARK 200  BEAMLINE                       : 14.2
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.91841
REMARK 200  MONOCHROMATOR                  : MIRROR
REMARK 200  OPTICS                         : MIRROR
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD (MX-225)
REMARK 200  DETECTOR MANUFACTURER          : MARRESEARCH
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : XDS
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 47507
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.99
REMARK 200  RESOLUTION RANGE LOW       (A) : 20.00
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : -3.0
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 95.6
REMARK 200  DATA REDUNDANCY                : 3.1
REMARK 200  R MERGE                    (I) : 0.08
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 11.30
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.99
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.11
REMARK 200  COMPLETENESS FOR SHELL     (%) : 90.0
REMARK 200  DATA REDUNDANCY IN SHELL       : 3.0
REMARK 200  R MERGE FOR SHELL          (I) : 0.51
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 2.40
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: 3GUU
REMARK 200
REMARK 200 REMARK: NONE
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 31
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 1.8
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 30% PEG 8000, 100 MM NAOAC PH
REMARK 280  4.5, 200 MM LI2SO4. CRYO SOLUTION: 20% PEG 8000, 20% PEG
REMARK 280  400
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X+1/2,-Y,Z+1/2
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       27.37650
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       64.57900
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       50.07500
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       64.57900
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       27.37650
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       50.07500
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 2670 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 27440 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -21.6 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     ALA A    11
REMARK 465     ALA A    12
REMARK 465     PHE A    13
REMARK 465     GLY A   397
REMARK 465     ALA A   398
REMARK 465     GLN A   399
REMARK 465     SER A   400
REMARK 465     VAL A   401
REMARK 465     MET A   402
REMARK 465     GLY A   403
REMARK 465     ALA A   404
REMARK 465     SER A   405
REMARK 465     GLY A   406
REMARK 465     PRO A   407
REMARK 465     PRO A   408
REMARK 465     ALA A   409
REMARK 465     GLN A   410
REMARK 465     ASP A   411
REMARK 465     VAL A   412
REMARK 465     LEU A   413
REMARK 465     GLY A   414
REMARK 465     ALA A   415
REMARK 465     ASP A   416
REMARK 465     LEU A   417
REMARK 465     ALA A   418
REMARK 465     SER A   419
REMARK 465     GLN A   420
REMARK 465     LEU A   421
REMARK 465     ARG A   422
REMARK 465     SER A   423
REMARK 465     LEU A   424
REMARK 465     GLN A   425
REMARK 465     GLY A   426
REMARK 465     LYS A   427
REMARK 465     PRO A   428
REMARK 465     SER A   429
REMARK 465     ALA A   430
REMARK 465     PHE A   431
REMARK 465     GLY A   432
REMARK 465     ASN A   433
REMARK 465     LYS A   434
REMARK 465     PRO A   435
REMARK 465     PHE A   436
REMARK 465     GLY A   437
REMARK 465     SER A   438
REMARK 465     ILE A   439
REMARK 465     SER A   440
REMARK 465     PRO A   441
REMARK 465     ALA A   442
REMARK 465     ALA A   443
REMARK 465     ALA A   444
REMARK 465     SER A   445
REMARK 465     PHE A   446
REMARK 465     LEU A   447
REMARK 465     GLU A   448
REMARK 465     GLN A   449
REMARK 465     LYS A   450
REMARK 465     LEU A   451
REMARK 465     ILE A   452
REMARK 465     SER A   453
REMARK 465     GLU A   454
REMARK 465     GLU A   455
REMARK 465     ASP A   456
REMARK 465     LEU A   457
REMARK 465     ASN A   458
REMARK 465     SER A   459
REMARK 465     ALA A   460
REMARK 465     VAL A   461
REMARK 465     ASP A   462
REMARK 465     HIS A   463
REMARK 465     HIS A   464
REMARK 465     HIS A   465
REMARK 465     HIS A   466
REMARK 465     HIS A   467
REMARK 465     HIS A   468
REMARK 465     ALA B    11
REMARK 465     ALA B    12
REMARK 465     PHE B    13
REMARK 465     GLY B   397
REMARK 465     ALA B   398
REMARK 465     GLN B   399
REMARK 465     SER B   400
REMARK 465     VAL B   401
REMARK 465     MET B   402
REMARK 465     GLY B   403
REMARK 465     ALA B   404
REMARK 465     SER B   405
REMARK 465     GLY B   406
REMARK 465     PRO B   407
REMARK 465     PRO B   408
REMARK 465     ALA B   409
REMARK 465     GLN B   410
REMARK 465     ASP B   411
REMARK 465     VAL B   412
REMARK 465     LEU B   413
REMARK 465     GLY B   414
REMARK 465     ALA B   415
REMARK 465     ASP B   416
REMARK 465     LEU B   417
REMARK 465     ALA B   418
REMARK 465     SER B   419
REMARK 465     GLN B   420
REMARK 465     LEU B   421
REMARK 465     ARG B   422
REMARK 465     SER B   423
REMARK 465     LEU B   424
REMARK 465     GLN B   425
REMARK 465     GLY B   426
REMARK 465     LYS B   427
REMARK 465     PRO B   428
REMARK 465     SER B   429
REMARK 465     ALA B   430
REMARK 465     PHE B   431
REMARK 465     GLY B   432
REMARK 465     ASN B   433
REMARK 465     LYS B   434
REMARK 465     PRO B   435
REMARK 465     PHE B   436
REMARK 465     GLY B   437
REMARK 465     SER B   438
REMARK 465     ILE B   439
REMARK 465     SER B   440
REMARK 465     PRO B   441
REMARK 465     ALA B   442
REMARK 465     ALA B   443
REMARK 465     ALA B   444
REMARK 465     SER B   445
REMARK 465     PHE B   446
REMARK 465     LEU B   447
REMARK 465     GLU B   448
REMARK 465     GLN B   449
REMARK 465     LYS B   450
REMARK 465     LEU B   451
REMARK 465     ILE B   452
REMARK 465     SER B   453
REMARK 465     GLU B   454
REMARK 465     GLU B   455
REMARK 465     ASP B   456
REMARK 465     LEU B   457
REMARK 465     ASN B   458
REMARK 465     SER B   459
REMARK 465     ALA B   460
REMARK 465     VAL B   461
REMARK 465     ASP B   462
REMARK 465     HIS B   463
REMARK 465     HIS B   464
REMARK 465     HIS B   465
REMARK 465     HIS B   466
REMARK 465     HIS B   467
REMARK 465     HIS B   468
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     GLY A 396    CA   C    O
REMARK 470     GLY B 396    CA   C    O
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   ND2  ASN A   291     O    HOH A  2127              2.16
REMARK 500   O    HOH A  2052     O    HOH A  2089              2.14
REMARK 500   O    HOH B  2052     O    HOH B  2080              2.10
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    LEU A 111      -47.80    -15.20
REMARK 500    ASP A 112       41.62    -83.75
REMARK 500    LEU A 121      -83.97    -99.46
REMARK 500    SER A 184     -115.09     64.23
REMARK 500    LYS A 227       -6.10     67.34
REMARK 500    CYS A 273     -157.14   -119.95
REMARK 500    GLU A 308       41.16    -95.48
REMARK 500    LEU A 333       40.90   -101.25
REMARK 500    ILE A 336      -53.25   -121.48
REMARK 500    GLU A 365     -166.77   -108.53
REMARK 500    ASP B 112       34.46    -78.08
REMARK 500    LEU B 121      -81.19   -101.78
REMARK 500    SER B 184     -119.29     62.92
REMARK 500    LYS B 227       -2.53     74.47
REMARK 500    CYS B 273     -156.09   -114.52
REMARK 500    ASP B 292       85.59    173.96
REMARK 500    GLU B 308       43.09   -101.88
REMARK 500    GLU B 365     -166.20   -108.89
REMARK 500
REMARK 500 REMARK: NULL
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEG A1401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE EDO A1402
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE EDO B1401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PG4 B1402
DBREF  3ZPX A   11   441  UNP    Q4P903   Q4P903_USTMA   152    582
DBREF  3ZPX B   11   441  UNP    Q4P903   Q4P903_USTMA   152    582
SEQADV 3ZPX ALA A  442  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX ALA A  443  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX ALA A  444  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX SER A  445  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX PHE A  446  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX LEU A  447  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX GLU A  448  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX GLN A  449  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX LYS A  450  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX LEU A  451  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX ILE A  452  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX SER A  453  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX GLU A  454  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX GLU A  455  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX ASP A  456  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX LEU A  457  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX ASN A  458  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX SER A  459  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX ALA A  460  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX VAL A  461  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX ASP A  462  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX HIS A  463  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX HIS A  464  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX HIS A  465  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX HIS A  466  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX HIS A  467  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX HIS A  468  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX ALA B  442  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX ALA B  443  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX ALA B  444  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX SER B  445  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX PHE B  446  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX LEU B  447  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX GLU B  448  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX GLN B  449  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX LYS B  450  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX LEU B  451  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX ILE B  452  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX SER B  453  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX GLU B  454  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX GLU B  455  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX ASP B  456  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX LEU B  457  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX ASN B  458  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX SER B  459  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX ALA B  460  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX VAL B  461  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX ASP B  462  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX HIS B  463  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX HIS B  464  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX HIS B  465  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX HIS B  466  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX HIS B  467  UNP  Q4P903              EXPRESSION TAG
SEQADV 3ZPX HIS B  468  UNP  Q4P903              EXPRESSION TAG
SEQRES   1 A  458  ALA ALA PHE ALA ASP PRO ASN ASP ASP LEU PHE TYR THR
SEQRES   2 A  458  THR PRO ASP ASN ILE ASN THR TYR ALA ASN GLY GLN VAL
SEQRES   3 A  458  ILE GLN SER ARG LYS ALA ASP THR ASP ILE GLY ASN SER
SEQRES   4 A  458  ASN LYS VAL GLU ALA PHE GLN LEU GLN TYR ARG THR THR
SEQRES   5 A  458  ASN THR GLN LYS GLU ALA GLN ALA ASN VAL ALA THR VAL
SEQRES   6 A  458  TRP ILE PRO ASN LYS PRO ALA SER PRO PRO LYS ILE PHE
SEQRES   7 A  458  SER TYR GLN VAL TYR GLN ASP SER THR GLN LEU ASN CYS
SEQRES   8 A  458  ALA PRO SER TYR SER PHE LEU LYS GLY LEU ASP LYS PRO
SEQRES   9 A  458  ASN LYS ALA THR THR ILE LEU GLU ALA PRO ILE ILE ILE
SEQRES  10 A  458  GLY TRP ALA LEU GLN GLN GLY PHE TYR VAL VAL SER SER
SEQRES  11 A  458  ASP HIS GLU GLY PRO ARG SER SER PHE ILE ALA GLY TYR
SEQRES  12 A  458  GLU GLU GLY MET ALA ILE LEU ASP GLY ILE ARG ALA LEU
SEQRES  13 A  458  LYS ASN TYR ALA LYS LEU PRO THR ASP SER ALA ILE GLY
SEQRES  14 A  458  PHE TYR GLY TYR SER GLY GLY ALA HIS ALA THR GLY TRP
SEQRES  15 A  458  ALA ALA ASN LEU ALA GLY SER TYR ALA PRO GLU HIS ASN
SEQRES  16 A  458  ILE ILE GLY ALA ALA TYR GLY GLY LEU PRO ALA SER ALA
SEQRES  17 A  458  ARG ASP THR PHE ASN PHE LEU ASN LYS GLY ALA PHE ALA
SEQRES  18 A  458  GLY PHE ALA ILE ALA GLY VAL SER GLY LEU ALA LEU ALA
SEQRES  19 A  458  TYR PRO ASP VAL GLU THR TYR ILE GLN SER ARG LEU ASN
SEQRES  20 A  458  ALA LYS GLY GLU LYS VAL PHE LYS GLN VAL ARG SER ARG
SEQRES  21 A  458  GLY PHE CYS ILE GLY GLN VAL VAL LEU THR TYR PRO PHE
SEQRES  22 A  458  VAL ASP ALA TYR SER LEU ILE ASN ASP THR ASN LEU LEU
SEQRES  23 A  458  ASN GLU GLU PRO VAL ALA SER THR LEU LYS SER GLU THR
SEQRES  24 A  458  LEU VAL GLN ALA GLU ALA SER TYR THR VAL PRO VAL PRO
SEQRES  25 A  458  LYS PHE PRO ARG PHE ILE TRP HIS ALA LEU LEU ASP GLU
SEQRES  26 A  458  ILE VAL PRO PHE HIS SER ALA ALA THR TYR VAL LYS GLU
SEQRES  27 A  458  GLN CYS SER LYS GLY ALA ASP ILE ASN TRP ASN VAL TYR
SEQRES  28 A  458  SER PHE ALA GLU HIS ILE SER ALA GLU LEU PHE GLY LEU
SEQRES  29 A  458  LEU PRO GLY LEU ASP TRP LEU ASN LYS ALA TYR LYS GLY
SEQRES  30 A  458  GLN ALA PRO LYS VAL PRO CYS GLY GLY GLY ALA GLN SER
SEQRES  31 A  458  VAL MET GLY ALA SER GLY PRO PRO ALA GLN ASP VAL LEU
SEQRES  32 A  458  GLY ALA ASP LEU ALA SER GLN LEU ARG SER LEU GLN GLY
SEQRES  33 A  458  LYS PRO SER ALA PHE GLY ASN LYS PRO PHE GLY SER ILE
SEQRES  34 A  458  SER PRO ALA ALA ALA SER PHE LEU GLU GLN LYS LEU ILE
SEQRES  35 A  458  SER GLU GLU ASP LEU ASN SER ALA VAL ASP HIS HIS HIS
SEQRES  36 A  458  HIS HIS HIS
SEQRES   1 B  458  ALA ALA PHE ALA ASP PRO ASN ASP ASP LEU PHE TYR THR
SEQRES   2 B  458  THR PRO ASP ASN ILE ASN THR TYR ALA ASN GLY GLN VAL
SEQRES   3 B  458  ILE GLN SER ARG LYS ALA ASP THR ASP ILE GLY ASN SER
SEQRES   4 B  458  ASN LYS VAL GLU ALA PHE GLN LEU GLN TYR ARG THR THR
SEQRES   5 B  458  ASN THR GLN LYS GLU ALA GLN ALA ASN VAL ALA THR VAL
SEQRES   6 B  458  TRP ILE PRO ASN LYS PRO ALA SER PRO PRO LYS ILE PHE
SEQRES   7 B  458  SER TYR GLN VAL TYR GLN ASP SER THR GLN LEU ASN CYS
SEQRES   8 B  458  ALA PRO SER TYR SER PHE LEU LYS GLY LEU ASP LYS PRO
SEQRES   9 B  458  ASN LYS ALA THR THR ILE LEU GLU ALA PRO ILE ILE ILE
SEQRES  10 B  458  GLY TRP ALA LEU GLN GLN GLY PHE TYR VAL VAL SER SER
SEQRES  11 B  458  ASP HIS GLU GLY PRO ARG SER SER PHE ILE ALA GLY TYR
SEQRES  12 B  458  GLU GLU GLY MET ALA ILE LEU ASP GLY ILE ARG ALA LEU
SEQRES  13 B  458  LYS ASN TYR ALA LYS LEU PRO THR ASP SER ALA ILE GLY
SEQRES  14 B  458  PHE TYR GLY TYR SER GLY GLY ALA HIS ALA THR GLY TRP
SEQRES  15 B  458  ALA ALA ASN LEU ALA GLY SER TYR ALA PRO GLU HIS ASN
SEQRES  16 B  458  ILE ILE GLY ALA ALA TYR GLY GLY LEU PRO ALA SER ALA
SEQRES  17 B  458  ARG ASP THR PHE ASN PHE LEU ASN LYS GLY ALA PHE ALA
SEQRES  18 B  458  GLY PHE ALA ILE ALA GLY VAL SER GLY LEU ALA LEU ALA
SEQRES  19 B  458  TYR PRO ASP VAL GLU THR TYR ILE GLN SER ARG LEU ASN
SEQRES  20 B  458  ALA LYS GLY GLU LYS VAL PHE LYS GLN VAL ARG SER ARG
SEQRES  21 B  458  GLY PHE CYS ILE GLY GLN VAL VAL LEU THR TYR PRO PHE
SEQRES  22 B  458  VAL ASP ALA TYR SER LEU ILE ASN ASP THR ASN LEU LEU
SEQRES  23 B  458  ASN GLU GLU PRO VAL ALA SER THR LEU LYS SER GLU THR
SEQRES  24 B  458  LEU VAL GLN ALA GLU ALA SER TYR THR VAL PRO VAL PRO
SEQRES  25 B  458  LYS PHE PRO ARG PHE ILE TRP HIS ALA LEU LEU ASP GLU
SEQRES  26 B  458  ILE VAL PRO PHE HIS SER ALA ALA THR TYR VAL LYS GLU
SEQRES  27 B  458  GLN CYS SER LYS GLY ALA ASP ILE ASN TRP ASN VAL TYR
SEQRES  28 B  458  SER PHE ALA GLU HIS ILE SER ALA GLU LEU PHE GLY LEU
SEQRES  29 B  458  LEU PRO GLY LEU ASP TRP LEU ASN LYS ALA TYR LYS GLY
SEQRES  30 B  458  GLN ALA PRO LYS VAL PRO CYS GLY GLY GLY ALA GLN SER
SEQRES  31 B  458  VAL MET GLY ALA SER GLY PRO PRO ALA GLN ASP VAL LEU
SEQRES  32 B  458  GLY ALA ASP LEU ALA SER GLN LEU ARG SER LEU GLN GLY
SEQRES  33 B  458  LYS PRO SER ALA PHE GLY ASN LYS PRO PHE GLY SER ILE
SEQRES  34 B  458  SER PRO ALA ALA ALA SER PHE LEU GLU GLN LYS LEU ILE
SEQRES  35 B  458  SER GLU GLU ASP LEU ASN SER ALA VAL ASP HIS HIS HIS
SEQRES  36 B  458  HIS HIS HIS
HET    PEG  A1401       7
HET    EDO  A1402       4
HET    EDO  B1401       4
HET    PG4  B1402      13
HETNAM     PG4 TETRAETHYLENE GLYCOL
HETNAM     EDO 1,2-ETHANEDIOL
HETNAM     PEG DI(HYDROXYETHYL)ETHER
HETSYN     EDO ETHYLENE GLYCOL
FORMUL   3  PG4    C8 H18 O5
FORMUL   4  EDO    2(C2 H6 O2)
FORMUL   5  PEG    C4 H10 O3
FORMUL   6  HOH   *319(H2 O)
HELIX    1   1 ASP A   15  ASP A   19  5                                   5
HELIX    2   2 ASP A   19  THR A   23  5                                   5
HELIX    3   3 ASN A   27  TYR A   31  5                                   5
HELIX    4   4 THR A   44  LYS A   51  1                                   8
HELIX    5   5 GLN A   98  CYS A  101  5                                   4
HELIX    6   6 ALA A  102  PHE A  107  1                                   6
HELIX    7   7 ASN A  115  ILE A  120  5                                   6
HELIX    8   8 LEU A  121  GLN A  133  1                                  13
HELIX    9   9 ALA A  151  ALA A  170  1                                  20
HELIX   10  10 SER A  184  ALA A  201  1                                  18
HELIX   11  11 SER A  217  ASN A  226  1                                  10
HELIX   12  12 PHE A  230  TYR A  245  1                                  16
HELIX   13  13 TYR A  245  LEU A  256  1                                  12
HELIX   14  14 ASN A  257  ARG A  268  1                                  12
HELIX   15  15 CYS A  273  TYR A  281  1                                   9
HELIX   16  16 ASP A  285  LEU A  289  5                                   5
HELIX   17  17 ASN A  294  GLU A  298  5                                   5
HELIX   18  18 PRO A  300  GLU A  308  1                                   9
HELIX   19  19 PRO A  338  LYS A  352  1                                  15
HELIX   20  20 GLU A  365  LYS A  386  1                                  22
HELIX   21  21 ASP B   15  ASP B   19  5                                   5
HELIX   22  22 ASP B   19  THR B   23  5                                   5
HELIX   23  23 ASN B   27  TYR B   31  5                                   5
HELIX   24  24 THR B   44  LYS B   51  1                                   8
HELIX   25  25 GLN B   98  CYS B  101  5                                   4
HELIX   26  26 ALA B  102  LEU B  108  1                                   7
HELIX   27  27 ASN B  115  THR B  119  5                                   5
HELIX   28  28 GLU B  122  GLN B  133  1                                  12
HELIX   29  29 ALA B  151  ALA B  170  1                                  20
HELIX   30  30 SER B  184  ALA B  201  1                                  18
HELIX   31  31 SER B  217  ASN B  226  1                                  10
HELIX   32  32 PHE B  230  TYR B  245  1                                  16
HELIX   33  33 TYR B  245  LEU B  256  1                                  12
HELIX   34  34 ASN B  257  ARG B  268  1                                  12
HELIX   35  35 CYS B  273  TYR B  281  1                                   9
HELIX   36  36 ASP B  285  LEU B  289  5                                   5
HELIX   37  37 ASN B  294  GLU B  298  5                                   5
HELIX   38  38 PRO B  300  GLU B  308  1                                   9
HELIX   39  39 VAL B  311  ALA B  315  5                                   5
HELIX   40  40 PRO B  338  LYS B  352  1                                  15
HELIX   41  41 GLU B  365  LYS B  386  1                                  22
SHEET    1  AA 9 VAL A  36  LYS A  41  0
SHEET    2  AA 9 GLU A  53  THR A  62 -1  O  GLN A  56   N  ARG A  40
SHEET    3  AA 9 ALA A  68  ILE A  77 -1  O  GLN A  69   N  THR A  61
SHEET    4  AA 9 TYR A 136  SER A 140 -1  O  VAL A 137   N  TRP A  76
SHEET    5  AA 9 LYS A  86  GLN A  91  1  O  LYS A  86   N  TYR A 136
SHEET    6  AA 9 ALA A 177  TYR A 183  1  O  ALA A 177   N  ILE A  87
SHEET    7  AA 9 ASN A 205  GLY A 212  1  O  ASN A 205   N  ILE A 178
SHEET    8  AA 9 ARG A 326  ALA A 331  1  O  PHE A 327   N  TYR A 211
SHEET    9  AA 9 ILE A 356  TYR A 361  1  O  ASN A 357   N  ILE A 328
SHEET    1  BA 9 VAL B  36  LYS B  41  0
SHEET    2  BA 9 GLU B  53  THR B  62 -1  O  GLN B  56   N  ARG B  40
SHEET    3  BA 9 ALA B  68  ILE B  77 -1  O  GLN B  69   N  THR B  61
SHEET    4  BA 9 TYR B 136  SER B 140 -1  O  VAL B 137   N  TRP B  76
SHEET    5  BA 9 LYS B  86  GLN B  91  1  O  LYS B  86   N  TYR B 136
SHEET    6  BA 9 ALA B 177  TYR B 183  1  O  ALA B 177   N  ILE B  87
SHEET    7  BA 9 ASN B 205  GLY B 212  1  O  ASN B 205   N  ILE B 178
SHEET    8  BA 9 PRO B 325  ALA B 331  1  O  PRO B 325   N  ALA B 209
SHEET    9  BA 9 ASP B 355  TYR B 361  1  O  ASP B 355   N  ARG B 326
SSBOND   1 CYS A  101    CYS A  273                          1555   1555  2.04
SSBOND   2 CYS A  350    CYS A  394                          1555   1555  2.04
SSBOND   3 CYS B  101    CYS B  273                          1555   1555  2.04
SSBOND   4 CYS B  350    CYS B  394                          1555   1555  2.03
CISPEP   1 SER A   83    PRO A   84          0        -1.85
CISPEP   2 GLU A  299    PRO A  300          0         1.09
CISPEP   3 SER B   83    PRO B   84          0        -5.96
CISPEP   4 GLU B  299    PRO B  300          0         6.16
SITE     1 AC1  5 ASN A 257  ALA A 258  ASN A 291  ASP A 379
SITE     2 AC1  5 HOH A2161
SITE     1 AC2  4 PRO A 320  PRO A 322  HOH A2092  HIS B 340
SITE     1 AC3  2 TRP B 358  VAL B 360
SITE     1 AC4  6 GLU B 299  LYS B 306  ALA B 313  ALA B 315
SITE     2 AC4  6 SER B 316  GLY B 353
CRYST1   54.753  100.150  129.158  90.00  90.00  90.00 P 21 21 21    8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.018264  0.000000  0.000000        0.00000
SCALE2      0.000000  0.009985  0.000000        0.00000
SCALE3      0.000000  0.000000  0.007742        0.00000
MTRIX1   1 -0.999930  0.002710  0.011420       -3.02917    1
MTRIX2   1  0.011710  0.294740  0.955510       21.74548    1
MTRIX3   1 -0.000770  0.955570 -0.294750      -28.94955    1
TER    2957      GLY A 396
TER    5969      GLY B 396
MASTER      511    0    4   41   18    0    6    9 6314    2   36   72
END