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HEADER DE NOVO PROTEIN 11-JAN-12 4D9J
TITLE STRUCTURE OF A 16 NM PROTEIN CAGE DESIGNED BY FUSING SYMMETRIC
TITLE 2 OLIGOMERIC DOMAINS
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: DESIGNED 16NM TETRAHEDRAL PROTEIN CAGE CONTAINING NON-HAEM
COMPND 3 BROMOPEROXIDASE BPO-A2 AND MATRIX PROTEIN 1;
COMPND 4 CHAIN: A, B, C, D, E, F, G, H, I, J, K, L;
COMPND 5 SYNONYM: BPO2, BROMIDE PEROXIDASE, M1;
COMPND 6 EC: 1.11.1.-;
COMPND 7 ENGINEERED: YES
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: STREPTOMYCES AUREOFACIENS, INFLUENZA A VIRUS;
SOURCE 3 ORGANISM_TAXID: 1894, 211044;
SOURCE 4 STRAIN: A/PUERTO RICO/8/1934 H1N1;
SOURCE 5 GENE: BPOA2, BROMOPEROXIDASE A2, M, M1 MATRIX;
SOURCE 6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 7 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE 8 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);
SOURCE 9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE 10 EXPRESSION_SYSTEM_PLASMID: PET22B
KEYWDS PROTEIN DESIGN, BIONANOTECHNOLOGY, PROTEIN ASSEMBLY, SYMMETRY,
KEYWDS 2 BIOMATERIALS, DE NOVO PROTEIN
EXPDTA X-RAY DIFFRACTION
AUTHOR Y.-T.LAI,D.CASCIO,T.O.YEATES
REVDAT 1 20-JUN-12 4D9J 0
JRNL AUTH Y.T.LAI,D.CASCIO,T.O.YEATES
JRNL TITL STRUCTURE OF A 16-NM CAGE DESIGNED BY USING PROTEIN
JRNL TITL 2 OLIGOMERS.
JRNL REF SCIENCE V. 336 1129 2012
JRNL REFN ISSN 0036-8075
JRNL PMID 22654051
JRNL DOI 10.1126/SCIENCE.1219351
REMARK 2
REMARK 2 RESOLUTION. 3.92 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 PROGRAM : PHENIX (PHENIX.REFINE: 1.7.3_928)
REMARK 3 AUTHORS : PAUL ADAMS,PAVEL AFONINE,VICENT CHEN,IAN
REMARK 3 : DAVIS,KRESHNA GOPAL,RALF GROSSE-
REMARK 3 : KUNSTLEVE,LI-WEI HUNG,ROBERT IMMORMINO,
REMARK 3 : TOM IOERGER,AIRLIE MCCOY,ERIK MCKEE,NIGEL
REMARK 3 : MORIARTY,REETAL PAI,RANDY READ,JANE
REMARK 3 : RICHARDSON,DAVID RICHARDSON,TOD ROMO,JIM
REMARK 3 : SACCHETTINI,NICHOLAS SAUTER,JACOB SMITH,
REMARK 3 : LAURENT STORONI,TOM TERWILLIGER,PETER
REMARK 3 : ZWART
REMARK 3
REMARK 3 REFINEMENT TARGET : ML
REMARK 3
REMARK 3 DATA USED IN REFINEMENT.
REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 3.92
REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 19.89
REMARK 3 MIN(FOBS/SIGMA_FOBS) : 1.990
REMARK 3 COMPLETENESS FOR RANGE (%) : 99.1
REMARK 3 NUMBER OF REFLECTIONS : 58465
REMARK 3
REMARK 3 FIT TO DATA USED IN REFINEMENT.
REMARK 3 R VALUE (WORKING + TEST SET) : 0.283
REMARK 3 R VALUE (WORKING SET) : 0.282
REMARK 3 FREE R VALUE : 0.294
REMARK 3 FREE R VALUE TEST SET SIZE (%) : 5.000
REMARK 3 FREE R VALUE TEST SET COUNT : 2924
REMARK 3
REMARK 3 FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK 3 BIN RESOLUTION RANGE COMPL. NWORK NFREE RWORK RFREE
REMARK 3 1 19.8935 - 10.3114 1.00 2810 148 0.2287 0.2228
REMARK 3 2 10.3114 - 8.3834 1.00 2744 145 0.2117 0.2229
REMARK 3 3 8.3834 - 7.3855 1.00 2725 143 0.2463 0.2232
REMARK 3 4 7.3855 - 6.7391 1.00 2700 143 0.2759 0.3111
REMARK 3 5 6.7391 - 6.2723 1.00 2676 140 0.3036 0.2877
REMARK 3 6 6.2723 - 5.9128 1.00 2667 141 0.3065 0.3815
REMARK 3 7 5.9128 - 5.6237 1.00 2693 141 0.3113 0.3316
REMARK 3 8 5.6237 - 5.3839 1.00 2643 140 0.2893 0.2991
REMARK 3 9 5.3839 - 5.1804 1.00 2680 141 0.2928 0.3039
REMARK 3 10 5.1804 - 5.0046 1.00 2636 138 0.2867 0.2894
REMARK 3 11 5.0046 - 4.8505 1.00 2683 142 0.2898 0.3375
REMARK 3 12 4.8505 - 4.7137 1.00 2619 137 0.2961 0.2795
REMARK 3 13 4.7137 - 4.5912 1.00 2652 140 0.3038 0.3290
REMARK 3 14 4.5912 - 4.4804 1.00 2639 139 0.3175 0.3401
REMARK 3 15 4.4804 - 4.3797 1.00 2633 139 0.3175 0.3652
REMARK 3 16 4.3797 - 4.2874 1.00 2655 139 0.3276 0.3162
REMARK 3 17 4.2874 - 4.2025 1.00 2621 138 0.3317 0.3450
REMARK 3 18 4.2025 - 4.1239 1.00 2665 141 0.3358 0.3444
REMARK 3 19 4.1239 - 4.0509 1.00 2612 137 0.3395 0.3685
REMARK 3 20 4.0509 - 3.9828 1.00 2615 138 0.3439 0.3904
REMARK 3 21 3.9828 - 3.9200 0.82 2173 114 0.3770 0.3689
REMARK 3
REMARK 3 BULK SOLVENT MODELLING.
REMARK 3 METHOD USED : FLAT BULK SOLVENT MODEL
REMARK 3 SOLVENT RADIUS : 1.10
REMARK 3 SHRINKAGE RADIUS : 0.86
REMARK 3 K_SOL : 0.27
REMARK 3 B_SOL : 0.00
REMARK 3
REMARK 3 ERROR ESTIMATES.
REMARK 3 COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED) : 0.520
REMARK 3 PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 29.150
REMARK 3
REMARK 3 B VALUES.
REMARK 3 FROM WILSON PLOT (A**2) : 99.43
REMARK 3 MEAN B VALUE (OVERALL, A**2) : 54.12
REMARK 3 OVERALL ANISOTROPIC B VALUE.
REMARK 3 B11 (A**2) : 67.60850
REMARK 3 B22 (A**2) : 77.48200
REMARK 3 B33 (A**2) : 79.90950
REMARK 3 B12 (A**2) : -0.00000
REMARK 3 B13 (A**2) : -0.00000
REMARK 3 B23 (A**2) : 0.00000
REMARK 3
REMARK 3 TWINNING INFORMATION.
REMARK 3 FRACTION: NULL
REMARK 3 OPERATOR: NULL
REMARK 3
REMARK 3 DEVIATIONS FROM IDEAL VALUES.
REMARK 3 RMSD COUNT
REMARK 3 BOND : 0.003 41520
REMARK 3 ANGLE : 0.726 56508
REMARK 3 CHIRALITY : 0.038 6396
REMARK 3 PLANARITY : 0.004 7344
REMARK 3 DIHEDRAL : 9.542 14736
REMARK 3
REMARK 3 TLS DETAILS
REMARK 3 NUMBER OF TLS GROUPS : NULL
REMARK 3
REMARK 3 NCS DETAILS
REMARK 3 NUMBER OF NCS GROUPS : NULL
REMARK 3
REMARK 3 OTHER REFINEMENT REMARKS: NULL
REMARK 4
REMARK 4 4D9J COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 18-JAN-12.
REMARK 100 THE RCSB ID CODE IS RCSB070052.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION
REMARK 200 DATE OF DATA COLLECTION : 03-DEC-11
REMARK 200 TEMPERATURE (KELVIN) : 100
REMARK 200 PH : 10.3
REMARK 200 NUMBER OF CRYSTALS USED : 1
REMARK 200
REMARK 200 SYNCHROTRON (Y/N) : Y
REMARK 200 RADIATION SOURCE : APS
REMARK 200 BEAMLINE : 24-ID-C
REMARK 200 X-RAY GENERATOR MODEL : NULL
REMARK 200 MONOCHROMATIC OR LAUE (M/L) : M
REMARK 200 WAVELENGTH OR RANGE (A) : 0.9794
REMARK 200 MONOCHROMATOR : SI 111
REMARK 200 OPTICS : NULL
REMARK 200
REMARK 200 DETECTOR TYPE : CCD
REMARK 200 DETECTOR MANUFACTURER : ADSC QUANTUM 315
REMARK 200 INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200 DATA SCALING SOFTWARE : XSCALE
REMARK 200
REMARK 200 NUMBER OF UNIQUE REFLECTIONS : 58471
REMARK 200 RESOLUTION RANGE HIGH (A) : 3.920
REMARK 200 RESOLUTION RANGE LOW (A) : 19.893
REMARK 200 REJECTION CRITERIA (SIGMA(I)) : -3.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200 COMPLETENESS FOR RANGE (%) : 98.2
REMARK 200 DATA REDUNDANCY : 7.097
REMARK 200 R MERGE (I) : 0.06600
REMARK 200 R SYM (I) : NULL
REMARK 200 FOR THE DATA SET : 21.1300
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.92
REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : 4.02
REMARK 200 COMPLETENESS FOR SHELL (%) : 88.5
REMARK 200 DATA REDUNDANCY IN SHELL : NULL
REMARK 200 R MERGE FOR SHELL (I) : 0.31700
REMARK 200 R SYM FOR SHELL (I) : NULL
REMARK 200 FOR SHELL : 6.290
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: PDB ENTRY 3VDX
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS (%): 54.46
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.70
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 1.2M NAH2PO4, 0.8M K2HPO4, 0.1M CAPS,
REMARK 280 PH 10.3, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 298K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 2 2 21
REMARK 290
REMARK 290 SYMOP SYMMETRY
REMARK 290 NNNMMM OPERATOR
REMARK 290 1555 X,Y,Z
REMARK 290 2555 -X,-Y,Z+1/2
REMARK 290 3555 -X,Y,-Z+1/2
REMARK 290 4555 X,-Y,-Z
REMARK 290
REMARK 290 WHERE NNN -> OPERATOR NUMBER
REMARK 290 MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000
REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000
REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000
REMARK 290 SMTRY1 2 -1.000000 0.000000 0.000000 0.00000
REMARK 290 SMTRY2 2 0.000000 -1.000000 0.000000 0.00000
REMARK 290 SMTRY3 2 0.000000 0.000000 1.000000 141.69500
REMARK 290 SMTRY1 3 -1.000000 0.000000 0.000000 0.00000
REMARK 290 SMTRY2 3 0.000000 1.000000 0.000000 0.00000
REMARK 290 SMTRY3 3 0.000000 0.000000 -1.000000 141.69500
REMARK 290 SMTRY1 4 1.000000 0.000000 0.000000 0.00000
REMARK 290 SMTRY2 4 0.000000 -1.000000 0.000000 0.00000
REMARK 290 SMTRY3 4 0.000000 0.000000 -1.000000 0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DODECAMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 350 BIOMT1 2 -1.000000 0.000000 0.000000 122.70000
REMARK 350 BIOMT2 2 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 2 0.000000 0.000000 -1.000000 -141.69500
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DODECAMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: G, H, I, J, K, L
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 350 BIOMT1 2 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 2 0.000000 -1.000000 0.000000 -187.41000
REMARK 350 BIOMT3 2 0.000000 0.000000 -1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 MET A 0
REMARK 465 ASP A 439
REMARK 465 SER A 440
REMARK 465 GLN A 441
REMARK 465 HIS A 442
REMARK 465 ARG A 443
REMARK 465 SER A 444
REMARK 465 HIS A 445
REMARK 465 ARG A 446
REMARK 465 GLN A 447
REMARK 465 LEU A 448
REMARK 465 GLU A 449
REMARK 465 HIS A 450
REMARK 465 HIS A 451
REMARK 465 HIS A 452
REMARK 465 HIS A 453
REMARK 465 HIS A 454
REMARK 465 HIS A 455
REMARK 465 MET B 0
REMARK 465 ASP B 439
REMARK 465 SER B 440
REMARK 465 GLN B 441
REMARK 465 HIS B 442
REMARK 465 ARG B 443
REMARK 465 SER B 444
REMARK 465 HIS B 445
REMARK 465 ARG B 446
REMARK 465 GLN B 447
REMARK 465 LEU B 448
REMARK 465 GLU B 449
REMARK 465 HIS B 450
REMARK 465 HIS B 451
REMARK 465 HIS B 452
REMARK 465 HIS B 453
REMARK 465 HIS B 454
REMARK 465 HIS B 455
REMARK 465 MET C 0
REMARK 465 ASP C 439
REMARK 465 SER C 440
REMARK 465 GLN C 441
REMARK 465 HIS C 442
REMARK 465 ARG C 443
REMARK 465 SER C 444
REMARK 465 HIS C 445
REMARK 465 ARG C 446
REMARK 465 GLN C 447
REMARK 465 LEU C 448
REMARK 465 GLU C 449
REMARK 465 HIS C 450
REMARK 465 HIS C 451
REMARK 465 HIS C 452
REMARK 465 HIS C 453
REMARK 465 HIS C 454
REMARK 465 HIS C 455
REMARK 465 MET D 0
REMARK 465 ASP D 439
REMARK 465 SER D 440
REMARK 465 GLN D 441
REMARK 465 HIS D 442
REMARK 465 ARG D 443
REMARK 465 SER D 444
REMARK 465 HIS D 445
REMARK 465 ARG D 446
REMARK 465 GLN D 447
REMARK 465 LEU D 448
REMARK 465 GLU D 449
REMARK 465 HIS D 450
REMARK 465 HIS D 451
REMARK 465 HIS D 452
REMARK 465 HIS D 453
REMARK 465 HIS D 454
REMARK 465 HIS D 455
REMARK 465 MET E 0
REMARK 465 ASP E 439
REMARK 465 SER E 440
REMARK 465 GLN E 441
REMARK 465 HIS E 442
REMARK 465 ARG E 443
REMARK 465 SER E 444
REMARK 465 HIS E 445
REMARK 465 ARG E 446
REMARK 465 GLN E 447
REMARK 465 LEU E 448
REMARK 465 GLU E 449
REMARK 465 HIS E 450
REMARK 465 HIS E 451
REMARK 465 HIS E 452
REMARK 465 HIS E 453
REMARK 465 HIS E 454
REMARK 465 HIS E 455
REMARK 465 MET F 0
REMARK 465 ASP F 439
REMARK 465 SER F 440
REMARK 465 GLN F 441
REMARK 465 HIS F 442
REMARK 465 ARG F 443
REMARK 465 SER F 444
REMARK 465 HIS F 445
REMARK 465 ARG F 446
REMARK 465 GLN F 447
REMARK 465 LEU F 448
REMARK 465 GLU F 449
REMARK 465 HIS F 450
REMARK 465 HIS F 451
REMARK 465 HIS F 452
REMARK 465 HIS F 453
REMARK 465 HIS F 454
REMARK 465 HIS F 455
REMARK 465 MET G 0
REMARK 465 ASP G 439
REMARK 465 SER G 440
REMARK 465 GLN G 441
REMARK 465 HIS G 442
REMARK 465 ARG G 443
REMARK 465 SER G 444
REMARK 465 HIS G 445
REMARK 465 ARG G 446
REMARK 465 GLN G 447
REMARK 465 LEU G 448
REMARK 465 GLU G 449
REMARK 465 HIS G 450
REMARK 465 HIS G 451
REMARK 465 HIS G 452
REMARK 465 HIS G 453
REMARK 465 HIS G 454
REMARK 465 HIS G 455
REMARK 465 MET H 0
REMARK 465 ASP H 439
REMARK 465 SER H 440
REMARK 465 GLN H 441
REMARK 465 HIS H 442
REMARK 465 ARG H 443
REMARK 465 SER H 444
REMARK 465 HIS H 445
REMARK 465 ARG H 446
REMARK 465 GLN H 447
REMARK 465 LEU H 448
REMARK 465 GLU H 449
REMARK 465 HIS H 450
REMARK 465 HIS H 451
REMARK 465 HIS H 452
REMARK 465 HIS H 453
REMARK 465 HIS H 454
REMARK 465 HIS H 455
REMARK 465 MET I 0
REMARK 465 ASP I 439
REMARK 465 SER I 440
REMARK 465 GLN I 441
REMARK 465 HIS I 442
REMARK 465 ARG I 443
REMARK 465 SER I 444
REMARK 465 HIS I 445
REMARK 465 ARG I 446
REMARK 465 GLN I 447
REMARK 465 LEU I 448
REMARK 465 GLU I 449
REMARK 465 HIS I 450
REMARK 465 HIS I 451
REMARK 465 HIS I 452
REMARK 465 HIS I 453
REMARK 465 HIS I 454
REMARK 465 HIS I 455
REMARK 465 MET J 0
REMARK 465 ASP J 439
REMARK 465 SER J 440
REMARK 465 GLN J 441
REMARK 465 HIS J 442
REMARK 465 ARG J 443
REMARK 465 SER J 444
REMARK 465 HIS J 445
REMARK 465 ARG J 446
REMARK 465 GLN J 447
REMARK 465 LEU J 448
REMARK 465 GLU J 449
REMARK 465 HIS J 450
REMARK 465 HIS J 451
REMARK 465 HIS J 452
REMARK 465 HIS J 453
REMARK 465 HIS J 454
REMARK 465 HIS J 455
REMARK 465 MET K 0
REMARK 465 ASP K 439
REMARK 465 SER K 440
REMARK 465 GLN K 441
REMARK 465 HIS K 442
REMARK 465 ARG K 443
REMARK 465 SER K 444
REMARK 465 HIS K 445
REMARK 465 ARG K 446
REMARK 465 GLN K 447
REMARK 465 LEU K 448
REMARK 465 GLU K 449
REMARK 465 HIS K 450
REMARK 465 HIS K 451
REMARK 465 HIS K 452
REMARK 465 HIS K 453
REMARK 465 HIS K 454
REMARK 465 HIS K 455
REMARK 465 MET L 0
REMARK 465 ASP L 439
REMARK 465 SER L 440
REMARK 465 GLN L 441
REMARK 465 HIS L 442
REMARK 465 ARG L 443
REMARK 465 SER L 444
REMARK 465 HIS L 445
REMARK 465 ARG L 446
REMARK 465 GLN L 447
REMARK 465 LEU L 448
REMARK 465 GLU L 449
REMARK 465 HIS L 450
REMARK 465 HIS L 451
REMARK 465 HIS L 452
REMARK 465 HIS L 453
REMARK 465 HIS L 454
REMARK 465 HIS L 455
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 ASN A 9 -116.71 55.03
REMARK 500 TYR A 71 72.18 -105.27
REMARK 500 SER A 98 -113.76 52.21
REMARK 500 ASP A 155 88.19 -155.60
REMARK 500 GLU A 172 -35.45 -135.36
REMARK 500 THR A 176 -77.10 -109.45
REMARK 500 TYR A 206 43.58 -88.91
REMARK 500 THR A 236 -86.73 -124.41
REMARK 500 HIS A 263 46.72 -108.16
REMARK 500 LEU A 357 -165.26 -113.73
REMARK 500 ALA A 420 76.60 -154.99
REMARK 500 ASN B 9 -116.95 55.02
REMARK 500 TYR B 71 71.83 -105.45
REMARK 500 SER B 98 -113.23 51.92
REMARK 500 ASP B 155 87.86 -154.93
REMARK 500 GLU B 172 -35.61 -135.61
REMARK 500 THR B 176 -76.76 -109.12
REMARK 500 TYR B 206 44.19 -89.11
REMARK 500 THR B 236 -86.18 -124.51
REMARK 500 HIS B 263 46.51 -107.70
REMARK 500 LEU B 357 -165.61 -113.37
REMARK 500 ALA B 420 76.27 44.42
REMARK 500 ASN C 9 -117.17 54.97
REMARK 500 TYR C 71 71.93 -105.05
REMARK 500 SER C 98 -113.72 51.75
REMARK 500 ASP C 155 88.22 -155.23
REMARK 500 GLU C 172 -35.48 -135.41
REMARK 500 THR C 176 -77.04 -109.45
REMARK 500 TYR C 206 42.95 -89.68
REMARK 500 THR C 236 -86.41 -124.41
REMARK 500 HIS C 263 46.77 -107.80
REMARK 500 LEU C 357 -165.33 -114.49
REMARK 500 ALA C 420 77.60 -154.99
REMARK 500 ASN D 9 -117.23 54.89
REMARK 500 TYR D 71 71.90 -105.77
REMARK 500 SER D 98 -113.40 52.17
REMARK 500 ASP D 155 87.80 -155.50
REMARK 500 GLU D 172 -35.86 -135.72
REMARK 500 THR D 176 -77.07 -109.49
REMARK 500 TYR D 206 43.46 -89.48
REMARK 500 THR D 236 -86.48 -124.30
REMARK 500 HIS D 263 46.65 -108.01
REMARK 500 LEU D 357 -164.79 -113.59
REMARK 500 ALA D 420 76.17 -154.98
REMARK 500 ASN E 9 -116.59 54.90
REMARK 500 TYR E 71 71.77 -105.54
REMARK 500 SER E 98 -113.08 51.97
REMARK 500 ASP E 155 87.81 -155.34
REMARK 500 GLU E 172 -35.41 -135.53
REMARK 500 THR E 176 -76.86 -109.38
REMARK 500
REMARK 500 THIS ENTRY HAS 130 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 3VDX RELATED DB: PDB
DBREF 4D9J A 0 277 UNP P29715 BPOA2_STRAU 1 278
DBREF 4D9J A 286 447 UNP P03485 M1_I34A1 3 164
DBREF 4D9J B 0 277 UNP P29715 BPOA2_STRAU 1 278
DBREF 4D9J B 286 447 UNP P03485 M1_I34A1 3 164
DBREF 4D9J C 0 277 UNP P29715 BPOA2_STRAU 1 278
DBREF 4D9J C 286 447 UNP P03485 M1_I34A1 3 164
DBREF 4D9J D 0 277 UNP P29715 BPOA2_STRAU 1 278
DBREF 4D9J D 286 447 UNP P03485 M1_I34A1 3 164
DBREF 4D9J E 0 277 UNP P29715 BPOA2_STRAU 1 278
DBREF 4D9J E 286 447 UNP P03485 M1_I34A1 3 164
DBREF 4D9J F 0 277 UNP P29715 BPOA2_STRAU 1 278
DBREF 4D9J F 286 447 UNP P03485 M1_I34A1 3 164
DBREF 4D9J G 0 277 UNP P29715 BPOA2_STRAU 1 278
DBREF 4D9J G 286 447 UNP P03485 M1_I34A1 3 164
DBREF 4D9J H 0 277 UNP P29715 BPOA2_STRAU 1 278
DBREF 4D9J H 286 447 UNP P03485 M1_I34A1 3 164
DBREF 4D9J I 0 277 UNP P29715 BPOA2_STRAU 1 278
DBREF 4D9J I 286 447 UNP P03485 M1_I34A1 3 164
DBREF 4D9J J 0 277 UNP P29715 BPOA2_STRAU 1 278
DBREF 4D9J J 286 447 UNP P03485 M1_I34A1 3 164
DBREF 4D9J K 0 277 UNP P29715 BPOA2_STRAU 1 278
DBREF 4D9J K 286 447 UNP P03485 M1_I34A1 3 164
DBREF 4D9J L 0 277 UNP P29715 BPOA2_STRAU 1 278
DBREF 4D9J L 286 447 UNP P03485 M1_I34A1 3 164
SEQADV 4D9J VAL A 24 UNP P29715 GLN 25 CONFLICT
SEQADV 4D9J ALA A 118 UNP P29715 LYS 119 CONFLICT
SEQADV 4D9J ALA A 278 UNP P29715 LINKER
SEQADV 4D9J LEU A 279 UNP P29715 LINKER
SEQADV 4D9J GLU A 280 UNP P29715 LINKER
SEQADV 4D9J ALA A 281 UNP P29715 LINKER
SEQADV 4D9J GLN A 282 UNP P29715 LINKER
SEQADV 4D9J LYS A 283 UNP P29715 LINKER
SEQADV 4D9J GLN A 284 UNP P29715 LINKER
SEQADV 4D9J LYS A 285 UNP P29715 LINKER
SEQADV 4D9J LEU A 448 UNP P03485 EXPRESSION TAG
SEQADV 4D9J GLU A 449 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS A 450 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS A 451 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS A 452 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS A 453 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS A 454 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS A 455 UNP P03485 EXPRESSION TAG
SEQADV 4D9J VAL B 24 UNP P29715 GLN 25 CONFLICT
SEQADV 4D9J ALA B 118 UNP P29715 LYS 119 CONFLICT
SEQADV 4D9J ALA B 278 UNP P29715 LINKER
SEQADV 4D9J LEU B 279 UNP P29715 LINKER
SEQADV 4D9J GLU B 280 UNP P29715 LINKER
SEQADV 4D9J ALA B 281 UNP P29715 LINKER
SEQADV 4D9J GLN B 282 UNP P29715 LINKER
SEQADV 4D9J LYS B 283 UNP P29715 LINKER
SEQADV 4D9J GLN B 284 UNP P29715 LINKER
SEQADV 4D9J LYS B 285 UNP P29715 LINKER
SEQADV 4D9J LEU B 448 UNP P03485 EXPRESSION TAG
SEQADV 4D9J GLU B 449 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS B 450 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS B 451 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS B 452 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS B 453 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS B 454 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS B 455 UNP P03485 EXPRESSION TAG
SEQADV 4D9J VAL C 24 UNP P29715 GLN 25 CONFLICT
SEQADV 4D9J ALA C 118 UNP P29715 LYS 119 CONFLICT
SEQADV 4D9J ALA C 278 UNP P29715 LINKER
SEQADV 4D9J LEU C 279 UNP P29715 LINKER
SEQADV 4D9J GLU C 280 UNP P29715 LINKER
SEQADV 4D9J ALA C 281 UNP P29715 LINKER
SEQADV 4D9J GLN C 282 UNP P29715 LINKER
SEQADV 4D9J LYS C 283 UNP P29715 LINKER
SEQADV 4D9J GLN C 284 UNP P29715 LINKER
SEQADV 4D9J LYS C 285 UNP P29715 LINKER
SEQADV 4D9J LEU C 448 UNP P03485 EXPRESSION TAG
SEQADV 4D9J GLU C 449 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS C 450 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS C 451 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS C 452 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS C 453 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS C 454 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS C 455 UNP P03485 EXPRESSION TAG
SEQADV 4D9J VAL D 24 UNP P29715 GLN 25 CONFLICT
SEQADV 4D9J ALA D 118 UNP P29715 LYS 119 CONFLICT
SEQADV 4D9J ALA D 278 UNP P29715 LINKER
SEQADV 4D9J LEU D 279 UNP P29715 LINKER
SEQADV 4D9J GLU D 280 UNP P29715 LINKER
SEQADV 4D9J ALA D 281 UNP P29715 LINKER
SEQADV 4D9J GLN D 282 UNP P29715 LINKER
SEQADV 4D9J LYS D 283 UNP P29715 LINKER
SEQADV 4D9J GLN D 284 UNP P29715 LINKER
SEQADV 4D9J LYS D 285 UNP P29715 LINKER
SEQADV 4D9J LEU D 448 UNP P03485 EXPRESSION TAG
SEQADV 4D9J GLU D 449 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS D 450 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS D 451 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS D 452 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS D 453 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS D 454 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS D 455 UNP P03485 EXPRESSION TAG
SEQADV 4D9J VAL E 24 UNP P29715 GLN 25 CONFLICT
SEQADV 4D9J ALA E 118 UNP P29715 LYS 119 CONFLICT
SEQADV 4D9J ALA E 278 UNP P29715 LINKER
SEQADV 4D9J LEU E 279 UNP P29715 LINKER
SEQADV 4D9J GLU E 280 UNP P29715 LINKER
SEQADV 4D9J ALA E 281 UNP P29715 LINKER
SEQADV 4D9J GLN E 282 UNP P29715 LINKER
SEQADV 4D9J LYS E 283 UNP P29715 LINKER
SEQADV 4D9J GLN E 284 UNP P29715 LINKER
SEQADV 4D9J LYS E 285 UNP P29715 LINKER
SEQADV 4D9J LEU E 448 UNP P03485 EXPRESSION TAG
SEQADV 4D9J GLU E 449 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS E 450 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS E 451 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS E 452 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS E 453 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS E 454 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS E 455 UNP P03485 EXPRESSION TAG
SEQADV 4D9J VAL F 24 UNP P29715 GLN 25 CONFLICT
SEQADV 4D9J ALA F 118 UNP P29715 LYS 119 CONFLICT
SEQADV 4D9J ALA F 278 UNP P29715 LINKER
SEQADV 4D9J LEU F 279 UNP P29715 LINKER
SEQADV 4D9J GLU F 280 UNP P29715 LINKER
SEQADV 4D9J ALA F 281 UNP P29715 LINKER
SEQADV 4D9J GLN F 282 UNP P29715 LINKER
SEQADV 4D9J LYS F 283 UNP P29715 LINKER
SEQADV 4D9J GLN F 284 UNP P29715 LINKER
SEQADV 4D9J LYS F 285 UNP P29715 LINKER
SEQADV 4D9J LEU F 448 UNP P03485 EXPRESSION TAG
SEQADV 4D9J GLU F 449 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS F 450 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS F 451 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS F 452 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS F 453 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS F 454 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS F 455 UNP P03485 EXPRESSION TAG
SEQADV 4D9J VAL G 24 UNP P29715 GLN 25 CONFLICT
SEQADV 4D9J ALA G 118 UNP P29715 LYS 119 CONFLICT
SEQADV 4D9J ALA G 278 UNP P29715 LINKER
SEQADV 4D9J LEU G 279 UNP P29715 LINKER
SEQADV 4D9J GLU G 280 UNP P29715 LINKER
SEQADV 4D9J ALA G 281 UNP P29715 LINKER
SEQADV 4D9J GLN G 282 UNP P29715 LINKER
SEQADV 4D9J LYS G 283 UNP P29715 LINKER
SEQADV 4D9J GLN G 284 UNP P29715 LINKER
SEQADV 4D9J LYS G 285 UNP P29715 LINKER
SEQADV 4D9J LEU G 448 UNP P03485 EXPRESSION TAG
SEQADV 4D9J GLU G 449 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS G 450 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS G 451 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS G 452 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS G 453 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS G 454 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS G 455 UNP P03485 EXPRESSION TAG
SEQADV 4D9J VAL H 24 UNP P29715 GLN 25 CONFLICT
SEQADV 4D9J ALA H 118 UNP P29715 LYS 119 CONFLICT
SEQADV 4D9J ALA H 278 UNP P29715 LINKER
SEQADV 4D9J LEU H 279 UNP P29715 LINKER
SEQADV 4D9J GLU H 280 UNP P29715 LINKER
SEQADV 4D9J ALA H 281 UNP P29715 LINKER
SEQADV 4D9J GLN H 282 UNP P29715 LINKER
SEQADV 4D9J LYS H 283 UNP P29715 LINKER
SEQADV 4D9J GLN H 284 UNP P29715 LINKER
SEQADV 4D9J LYS H 285 UNP P29715 LINKER
SEQADV 4D9J LEU H 448 UNP P03485 EXPRESSION TAG
SEQADV 4D9J GLU H 449 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS H 450 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS H 451 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS H 452 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS H 453 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS H 454 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS H 455 UNP P03485 EXPRESSION TAG
SEQADV 4D9J VAL I 24 UNP P29715 GLN 25 CONFLICT
SEQADV 4D9J ALA I 118 UNP P29715 LYS 119 CONFLICT
SEQADV 4D9J ALA I 278 UNP P29715 LINKER
SEQADV 4D9J LEU I 279 UNP P29715 LINKER
SEQADV 4D9J GLU I 280 UNP P29715 LINKER
SEQADV 4D9J ALA I 281 UNP P29715 LINKER
SEQADV 4D9J GLN I 282 UNP P29715 LINKER
SEQADV 4D9J LYS I 283 UNP P29715 LINKER
SEQADV 4D9J GLN I 284 UNP P29715 LINKER
SEQADV 4D9J LYS I 285 UNP P29715 LINKER
SEQADV 4D9J LEU I 448 UNP P03485 EXPRESSION TAG
SEQADV 4D9J GLU I 449 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS I 450 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS I 451 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS I 452 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS I 453 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS I 454 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS I 455 UNP P03485 EXPRESSION TAG
SEQADV 4D9J VAL J 24 UNP P29715 GLN 25 CONFLICT
SEQADV 4D9J ALA J 118 UNP P29715 LYS 119 CONFLICT
SEQADV 4D9J ALA J 278 UNP P29715 LINKER
SEQADV 4D9J LEU J 279 UNP P29715 LINKER
SEQADV 4D9J GLU J 280 UNP P29715 LINKER
SEQADV 4D9J ALA J 281 UNP P29715 LINKER
SEQADV 4D9J GLN J 282 UNP P29715 LINKER
SEQADV 4D9J LYS J 283 UNP P29715 LINKER
SEQADV 4D9J GLN J 284 UNP P29715 LINKER
SEQADV 4D9J LYS J 285 UNP P29715 LINKER
SEQADV 4D9J LEU J 448 UNP P03485 EXPRESSION TAG
SEQADV 4D9J GLU J 449 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS J 450 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS J 451 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS J 452 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS J 453 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS J 454 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS J 455 UNP P03485 EXPRESSION TAG
SEQADV 4D9J VAL K 24 UNP P29715 GLN 25 CONFLICT
SEQADV 4D9J ALA K 118 UNP P29715 LYS 119 CONFLICT
SEQADV 4D9J ALA K 278 UNP P29715 LINKER
SEQADV 4D9J LEU K 279 UNP P29715 LINKER
SEQADV 4D9J GLU K 280 UNP P29715 LINKER
SEQADV 4D9J ALA K 281 UNP P29715 LINKER
SEQADV 4D9J GLN K 282 UNP P29715 LINKER
SEQADV 4D9J LYS K 283 UNP P29715 LINKER
SEQADV 4D9J GLN K 284 UNP P29715 LINKER
SEQADV 4D9J LYS K 285 UNP P29715 LINKER
SEQADV 4D9J LEU K 448 UNP P03485 EXPRESSION TAG
SEQADV 4D9J GLU K 449 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS K 450 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS K 451 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS K 452 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS K 453 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS K 454 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS K 455 UNP P03485 EXPRESSION TAG
SEQADV 4D9J VAL L 24 UNP P29715 GLN 25 CONFLICT
SEQADV 4D9J ALA L 118 UNP P29715 LYS 119 CONFLICT
SEQADV 4D9J ALA L 278 UNP P29715 LINKER
SEQADV 4D9J LEU L 279 UNP P29715 LINKER
SEQADV 4D9J GLU L 280 UNP P29715 LINKER
SEQADV 4D9J ALA L 281 UNP P29715 LINKER
SEQADV 4D9J GLN L 282 UNP P29715 LINKER
SEQADV 4D9J LYS L 283 UNP P29715 LINKER
SEQADV 4D9J GLN L 284 UNP P29715 LINKER
SEQADV 4D9J LYS L 285 UNP P29715 LINKER
SEQADV 4D9J LEU L 448 UNP P03485 EXPRESSION TAG
SEQADV 4D9J GLU L 449 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS L 450 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS L 451 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS L 452 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS L 453 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS L 454 UNP P03485 EXPRESSION TAG
SEQADV 4D9J HIS L 455 UNP P03485 EXPRESSION TAG
SEQRES 1 A 456 MET PRO PHE ILE THR VAL GLY GLN GLU ASN SER THR SER
SEQRES 2 A 456 ILE ASP LEU TYR TYR GLU ASP HIS GLY THR GLY VAL PRO
SEQRES 3 A 456 VAL VAL LEU ILE HIS GLY PHE PRO LEU SER GLY HIS SER
SEQRES 4 A 456 TRP GLU ARG GLN SER ALA ALA LEU LEU ASP ALA GLY TYR
SEQRES 5 A 456 ARG VAL ILE THR TYR ASP ARG ARG GLY PHE GLY GLN SER
SEQRES 6 A 456 SER GLN PRO THR THR GLY TYR ASP TYR ASP THR PHE ALA
SEQRES 7 A 456 ALA ASP LEU ASN THR VAL LEU GLU THR LEU ASP LEU GLN
SEQRES 8 A 456 ASP ALA VAL LEU VAL GLY PHE SER MET GLY THR GLY GLU
SEQRES 9 A 456 VAL ALA ARG TYR VAL SER SER TYR GLY THR ALA ARG ILE
SEQRES 10 A 456 ALA ALA VAL ALA PHE LEU ALA SER LEU GLU PRO PHE LEU
SEQRES 11 A 456 LEU LYS THR ASP ASP ASN PRO ASP GLY ALA ALA PRO GLN
SEQRES 12 A 456 GLU PHE PHE ASP GLY ILE VAL ALA ALA VAL LYS ALA ASP
SEQRES 13 A 456 ARG TYR ALA PHE TYR THR GLY PHE PHE ASN ASP PHE TYR
SEQRES 14 A 456 ASN LEU ASP GLU ASN LEU GLY THR ARG ILE SER GLU GLU
SEQRES 15 A 456 ALA VAL ARG ASN SER TRP ASN THR ALA ALA SER GLY GLY
SEQRES 16 A 456 PHE PHE ALA ALA ALA ALA ALA PRO THR THR TRP TYR THR
SEQRES 17 A 456 ASP PHE ARG ALA ASP ILE PRO ARG ILE ASP VAL PRO ALA
SEQRES 18 A 456 LEU ILE LEU HIS GLY THR GLY ASP ARG THR LEU PRO ILE
SEQRES 19 A 456 GLU ASN THR ALA ARG VAL PHE HIS LYS ALA LEU PRO SER
SEQRES 20 A 456 ALA GLU TYR VAL GLU VAL GLU GLY ALA PRO HIS GLY LEU
SEQRES 21 A 456 LEU TRP THR HIS ALA GLU GLU VAL ASN THR ALA LEU LEU
SEQRES 22 A 456 ALA PHE LEU ALA LYS ALA LEU GLU ALA GLN LYS GLN LYS
SEQRES 23 A 456 LEU LEU THR GLU VAL GLU THR TYR VAL LEU SER ILE ILE
SEQRES 24 A 456 PRO SER GLY PRO LEU LYS ALA GLU ILE ALA GLN ARG LEU
SEQRES 25 A 456 GLU ASP VAL PHE ALA GLY LYS ASN THR ASP LEU GLU VAL
SEQRES 26 A 456 LEU MET GLU TRP LEU LYS THR ARG PRO ILE LEU SER PRO
SEQRES 27 A 456 LEU THR LYS GLY ILE LEU GLY PHE VAL PHE THR LEU THR
SEQRES 28 A 456 VAL PRO SER GLU ARG GLY LEU GLN ARG ARG ARG PHE VAL
SEQRES 29 A 456 GLN ASN ALA LEU ASN GLY ASN GLY ASP PRO ASN ASN MET
SEQRES 30 A 456 ASP LYS ALA VAL LYS LEU TYR ARG LYS LEU LYS ARG GLU
SEQRES 31 A 456 ILE THR PHE HIS GLY ALA LYS GLU ILE SER LEU SER TYR
SEQRES 32 A 456 SER ALA GLY ALA LEU ALA SER CYS MET GLY LEU ILE TYR
SEQRES 33 A 456 ASN ARG MET GLY ALA VAL THR THR GLU VAL ALA PHE GLY
SEQRES 34 A 456 LEU VAL CYS ALA THR CYS GLU GLN ILE ALA ASP SER GLN
SEQRES 35 A 456 HIS ARG SER HIS ARG GLN LEU GLU HIS HIS HIS HIS HIS
SEQRES 36 A 456 HIS
SEQRES 1 B 456 MET PRO PHE ILE THR VAL GLY GLN GLU ASN SER THR SER
SEQRES 2 B 456 ILE ASP LEU TYR TYR GLU ASP HIS GLY THR GLY VAL PRO
SEQRES 3 B 456 VAL VAL LEU ILE HIS GLY PHE PRO LEU SER GLY HIS SER
SEQRES 4 B 456 TRP GLU ARG GLN SER ALA ALA LEU LEU ASP ALA GLY TYR
SEQRES 5 B 456 ARG VAL ILE THR TYR ASP ARG ARG GLY PHE GLY GLN SER
SEQRES 6 B 456 SER GLN PRO THR THR GLY TYR ASP TYR ASP THR PHE ALA
SEQRES 7 B 456 ALA ASP LEU ASN THR VAL LEU GLU THR LEU ASP LEU GLN
SEQRES 8 B 456 ASP ALA VAL LEU VAL GLY PHE SER MET GLY THR GLY GLU
SEQRES 9 B 456 VAL ALA ARG TYR VAL SER SER TYR GLY THR ALA ARG ILE
SEQRES 10 B 456 ALA ALA VAL ALA PHE LEU ALA SER LEU GLU PRO PHE LEU
SEQRES 11 B 456 LEU LYS THR ASP ASP ASN PRO ASP GLY ALA ALA PRO GLN
SEQRES 12 B 456 GLU PHE PHE ASP GLY ILE VAL ALA ALA VAL LYS ALA ASP
SEQRES 13 B 456 ARG TYR ALA PHE TYR THR GLY PHE PHE ASN ASP PHE TYR
SEQRES 14 B 456 ASN LEU ASP GLU ASN LEU GLY THR ARG ILE SER GLU GLU
SEQRES 15 B 456 ALA VAL ARG ASN SER TRP ASN THR ALA ALA SER GLY GLY
SEQRES 16 B 456 PHE PHE ALA ALA ALA ALA ALA PRO THR THR TRP TYR THR
SEQRES 17 B 456 ASP PHE ARG ALA ASP ILE PRO ARG ILE ASP VAL PRO ALA
SEQRES 18 B 456 LEU ILE LEU HIS GLY THR GLY ASP ARG THR LEU PRO ILE
SEQRES 19 B 456 GLU ASN THR ALA ARG VAL PHE HIS LYS ALA LEU PRO SER
SEQRES 20 B 456 ALA GLU TYR VAL GLU VAL GLU GLY ALA PRO HIS GLY LEU
SEQRES 21 B 456 LEU TRP THR HIS ALA GLU GLU VAL ASN THR ALA LEU LEU
SEQRES 22 B 456 ALA PHE LEU ALA LYS ALA LEU GLU ALA GLN LYS GLN LYS
SEQRES 23 B 456 LEU LEU THR GLU VAL GLU THR TYR VAL LEU SER ILE ILE
SEQRES 24 B 456 PRO SER GLY PRO LEU LYS ALA GLU ILE ALA GLN ARG LEU
SEQRES 25 B 456 GLU ASP VAL PHE ALA GLY LYS ASN THR ASP LEU GLU VAL
SEQRES 26 B 456 LEU MET GLU TRP LEU LYS THR ARG PRO ILE LEU SER PRO
SEQRES 27 B 456 LEU THR LYS GLY ILE LEU GLY PHE VAL PHE THR LEU THR
SEQRES 28 B 456 VAL PRO SER GLU ARG GLY LEU GLN ARG ARG ARG PHE VAL
SEQRES 29 B 456 GLN ASN ALA LEU ASN GLY ASN GLY ASP PRO ASN ASN MET
SEQRES 30 B 456 ASP LYS ALA VAL LYS LEU TYR ARG LYS LEU LYS ARG GLU
SEQRES 31 B 456 ILE THR PHE HIS GLY ALA LYS GLU ILE SER LEU SER TYR
SEQRES 32 B 456 SER ALA GLY ALA LEU ALA SER CYS MET GLY LEU ILE TYR
SEQRES 33 B 456 ASN ARG MET GLY ALA VAL THR THR GLU VAL ALA PHE GLY
SEQRES 34 B 456 LEU VAL CYS ALA THR CYS GLU GLN ILE ALA ASP SER GLN
SEQRES 35 B 456 HIS ARG SER HIS ARG GLN LEU GLU HIS HIS HIS HIS HIS
SEQRES 36 B 456 HIS
SEQRES 1 C 456 MET PRO PHE ILE THR VAL GLY GLN GLU ASN SER THR SER
SEQRES 2 C 456 ILE ASP LEU TYR TYR GLU ASP HIS GLY THR GLY VAL PRO
SEQRES 3 C 456 VAL VAL LEU ILE HIS GLY PHE PRO LEU SER GLY HIS SER
SEQRES 4 C 456 TRP GLU ARG GLN SER ALA ALA LEU LEU ASP ALA GLY TYR
SEQRES 5 C 456 ARG VAL ILE THR TYR ASP ARG ARG GLY PHE GLY GLN SER
SEQRES 6 C 456 SER GLN PRO THR THR GLY TYR ASP TYR ASP THR PHE ALA
SEQRES 7 C 456 ALA ASP LEU ASN THR VAL LEU GLU THR LEU ASP LEU GLN
SEQRES 8 C 456 ASP ALA VAL LEU VAL GLY PHE SER MET GLY THR GLY GLU
SEQRES 9 C 456 VAL ALA ARG TYR VAL SER SER TYR GLY THR ALA ARG ILE
SEQRES 10 C 456 ALA ALA VAL ALA PHE LEU ALA SER LEU GLU PRO PHE LEU
SEQRES 11 C 456 LEU LYS THR ASP ASP ASN PRO ASP GLY ALA ALA PRO GLN
SEQRES 12 C 456 GLU PHE PHE ASP GLY ILE VAL ALA ALA VAL LYS ALA ASP
SEQRES 13 C 456 ARG TYR ALA PHE TYR THR GLY PHE PHE ASN ASP PHE TYR
SEQRES 14 C 456 ASN LEU ASP GLU ASN LEU GLY THR ARG ILE SER GLU GLU
SEQRES 15 C 456 ALA VAL ARG ASN SER TRP ASN THR ALA ALA SER GLY GLY
SEQRES 16 C 456 PHE PHE ALA ALA ALA ALA ALA PRO THR THR TRP TYR THR
SEQRES 17 C 456 ASP PHE ARG ALA ASP ILE PRO ARG ILE ASP VAL PRO ALA
SEQRES 18 C 456 LEU ILE LEU HIS GLY THR GLY ASP ARG THR LEU PRO ILE
SEQRES 19 C 456 GLU ASN THR ALA ARG VAL PHE HIS LYS ALA LEU PRO SER
SEQRES 20 C 456 ALA GLU TYR VAL GLU VAL GLU GLY ALA PRO HIS GLY LEU
SEQRES 21 C 456 LEU TRP THR HIS ALA GLU GLU VAL ASN THR ALA LEU LEU
SEQRES 22 C 456 ALA PHE LEU ALA LYS ALA LEU GLU ALA GLN LYS GLN LYS
SEQRES 23 C 456 LEU LEU THR GLU VAL GLU THR TYR VAL LEU SER ILE ILE
SEQRES 24 C 456 PRO SER GLY PRO LEU LYS ALA GLU ILE ALA GLN ARG LEU
SEQRES 25 C 456 GLU ASP VAL PHE ALA GLY LYS ASN THR ASP LEU GLU VAL
SEQRES 26 C 456 LEU MET GLU TRP LEU LYS THR ARG PRO ILE LEU SER PRO
SEQRES 27 C 456 LEU THR LYS GLY ILE LEU GLY PHE VAL PHE THR LEU THR
SEQRES 28 C 456 VAL PRO SER GLU ARG GLY LEU GLN ARG ARG ARG PHE VAL
SEQRES 29 C 456 GLN ASN ALA LEU ASN GLY ASN GLY ASP PRO ASN ASN MET
SEQRES 30 C 456 ASP LYS ALA VAL LYS LEU TYR ARG LYS LEU LYS ARG GLU
SEQRES 31 C 456 ILE THR PHE HIS GLY ALA LYS GLU ILE SER LEU SER TYR
SEQRES 32 C 456 SER ALA GLY ALA LEU ALA SER CYS MET GLY LEU ILE TYR
SEQRES 33 C 456 ASN ARG MET GLY ALA VAL THR THR GLU VAL ALA PHE GLY
SEQRES 34 C 456 LEU VAL CYS ALA THR CYS GLU GLN ILE ALA ASP SER GLN
SEQRES 35 C 456 HIS ARG SER HIS ARG GLN LEU GLU HIS HIS HIS HIS HIS
SEQRES 36 C 456 HIS
SEQRES 1 D 456 MET PRO PHE ILE THR VAL GLY GLN GLU ASN SER THR SER
SEQRES 2 D 456 ILE ASP LEU TYR TYR GLU ASP HIS GLY THR GLY VAL PRO
SEQRES 3 D 456 VAL VAL LEU ILE HIS GLY PHE PRO LEU SER GLY HIS SER
SEQRES 4 D 456 TRP GLU ARG GLN SER ALA ALA LEU LEU ASP ALA GLY TYR
SEQRES 5 D 456 ARG VAL ILE THR TYR ASP ARG ARG GLY PHE GLY GLN SER
SEQRES 6 D 456 SER GLN PRO THR THR GLY TYR ASP TYR ASP THR PHE ALA
SEQRES 7 D 456 ALA ASP LEU ASN THR VAL LEU GLU THR LEU ASP LEU GLN
SEQRES 8 D 456 ASP ALA VAL LEU VAL GLY PHE SER MET GLY THR GLY GLU
SEQRES 9 D 456 VAL ALA ARG TYR VAL SER SER TYR GLY THR ALA ARG ILE
SEQRES 10 D 456 ALA ALA VAL ALA PHE LEU ALA SER LEU GLU PRO PHE LEU
SEQRES 11 D 456 LEU LYS THR ASP ASP ASN PRO ASP GLY ALA ALA PRO GLN
SEQRES 12 D 456 GLU PHE PHE ASP GLY ILE VAL ALA ALA VAL LYS ALA ASP
SEQRES 13 D 456 ARG TYR ALA PHE TYR THR GLY PHE PHE ASN ASP PHE TYR
SEQRES 14 D 456 ASN LEU ASP GLU ASN LEU GLY THR ARG ILE SER GLU GLU
SEQRES 15 D 456 ALA VAL ARG ASN SER TRP ASN THR ALA ALA SER GLY GLY
SEQRES 16 D 456 PHE PHE ALA ALA ALA ALA ALA PRO THR THR TRP TYR THR
SEQRES 17 D 456 ASP PHE ARG ALA ASP ILE PRO ARG ILE ASP VAL PRO ALA
SEQRES 18 D 456 LEU ILE LEU HIS GLY THR GLY ASP ARG THR LEU PRO ILE
SEQRES 19 D 456 GLU ASN THR ALA ARG VAL PHE HIS LYS ALA LEU PRO SER
SEQRES 20 D 456 ALA GLU TYR VAL GLU VAL GLU GLY ALA PRO HIS GLY LEU
SEQRES 21 D 456 LEU TRP THR HIS ALA GLU GLU VAL ASN THR ALA LEU LEU
SEQRES 22 D 456 ALA PHE LEU ALA LYS ALA LEU GLU ALA GLN LYS GLN LYS
SEQRES 23 D 456 LEU LEU THR GLU VAL GLU THR TYR VAL LEU SER ILE ILE
SEQRES 24 D 456 PRO SER GLY PRO LEU LYS ALA GLU ILE ALA GLN ARG LEU
SEQRES 25 D 456 GLU ASP VAL PHE ALA GLY LYS ASN THR ASP LEU GLU VAL
SEQRES 26 D 456 LEU MET GLU TRP LEU LYS THR ARG PRO ILE LEU SER PRO
SEQRES 27 D 456 LEU THR LYS GLY ILE LEU GLY PHE VAL PHE THR LEU THR
SEQRES 28 D 456 VAL PRO SER GLU ARG GLY LEU GLN ARG ARG ARG PHE VAL
SEQRES 29 D 456 GLN ASN ALA LEU ASN GLY ASN GLY ASP PRO ASN ASN MET
SEQRES 30 D 456 ASP LYS ALA VAL LYS LEU TYR ARG LYS LEU LYS ARG GLU
SEQRES 31 D 456 ILE THR PHE HIS GLY ALA LYS GLU ILE SER LEU SER TYR
SEQRES 32 D 456 SER ALA GLY ALA LEU ALA SER CYS MET GLY LEU ILE TYR
SEQRES 33 D 456 ASN ARG MET GLY ALA VAL THR THR GLU VAL ALA PHE GLY
SEQRES 34 D 456 LEU VAL CYS ALA THR CYS GLU GLN ILE ALA ASP SER GLN
SEQRES 35 D 456 HIS ARG SER HIS ARG GLN LEU GLU HIS HIS HIS HIS HIS
SEQRES 36 D 456 HIS
SEQRES 1 E 456 MET PRO PHE ILE THR VAL GLY GLN GLU ASN SER THR SER
SEQRES 2 E 456 ILE ASP LEU TYR TYR GLU ASP HIS GLY THR GLY VAL PRO
SEQRES 3 E 456 VAL VAL LEU ILE HIS GLY PHE PRO LEU SER GLY HIS SER
SEQRES 4 E 456 TRP GLU ARG GLN SER ALA ALA LEU LEU ASP ALA GLY TYR
SEQRES 5 E 456 ARG VAL ILE THR TYR ASP ARG ARG GLY PHE GLY GLN SER
SEQRES 6 E 456 SER GLN PRO THR THR GLY TYR ASP TYR ASP THR PHE ALA
SEQRES 7 E 456 ALA ASP LEU ASN THR VAL LEU GLU THR LEU ASP LEU GLN
SEQRES 8 E 456 ASP ALA VAL LEU VAL GLY PHE SER MET GLY THR GLY GLU
SEQRES 9 E 456 VAL ALA ARG TYR VAL SER SER TYR GLY THR ALA ARG ILE
SEQRES 10 E 456 ALA ALA VAL ALA PHE LEU ALA SER LEU GLU PRO PHE LEU
SEQRES 11 E 456 LEU LYS THR ASP ASP ASN PRO ASP GLY ALA ALA PRO GLN
SEQRES 12 E 456 GLU PHE PHE ASP GLY ILE VAL ALA ALA VAL LYS ALA ASP
SEQRES 13 E 456 ARG TYR ALA PHE TYR THR GLY PHE PHE ASN ASP PHE TYR
SEQRES 14 E 456 ASN LEU ASP GLU ASN LEU GLY THR ARG ILE SER GLU GLU
SEQRES 15 E 456 ALA VAL ARG ASN SER TRP ASN THR ALA ALA SER GLY GLY
SEQRES 16 E 456 PHE PHE ALA ALA ALA ALA ALA PRO THR THR TRP TYR THR
SEQRES 17 E 456 ASP PHE ARG ALA ASP ILE PRO ARG ILE ASP VAL PRO ALA
SEQRES 18 E 456 LEU ILE LEU HIS GLY THR GLY ASP ARG THR LEU PRO ILE
SEQRES 19 E 456 GLU ASN THR ALA ARG VAL PHE HIS LYS ALA LEU PRO SER
SEQRES 20 E 456 ALA GLU TYR VAL GLU VAL GLU GLY ALA PRO HIS GLY LEU
SEQRES 21 E 456 LEU TRP THR HIS ALA GLU GLU VAL ASN THR ALA LEU LEU
SEQRES 22 E 456 ALA PHE LEU ALA LYS ALA LEU GLU ALA GLN LYS GLN LYS
SEQRES 23 E 456 LEU LEU THR GLU VAL GLU THR TYR VAL LEU SER ILE ILE
SEQRES 24 E 456 PRO SER GLY PRO LEU LYS ALA GLU ILE ALA GLN ARG LEU
SEQRES 25 E 456 GLU ASP VAL PHE ALA GLY LYS ASN THR ASP LEU GLU VAL
SEQRES 26 E 456 LEU MET GLU TRP LEU LYS THR ARG PRO ILE LEU SER PRO
SEQRES 27 E 456 LEU THR LYS GLY ILE LEU GLY PHE VAL PHE THR LEU THR
SEQRES 28 E 456 VAL PRO SER GLU ARG GLY LEU GLN ARG ARG ARG PHE VAL
SEQRES 29 E 456 GLN ASN ALA LEU ASN GLY ASN GLY ASP PRO ASN ASN MET
SEQRES 30 E 456 ASP LYS ALA VAL LYS LEU TYR ARG LYS LEU LYS ARG GLU
SEQRES 31 E 456 ILE THR PHE HIS GLY ALA LYS GLU ILE SER LEU SER TYR
SEQRES 32 E 456 SER ALA GLY ALA LEU ALA SER CYS MET GLY LEU ILE TYR
SEQRES 33 E 456 ASN ARG MET GLY ALA VAL THR THR GLU VAL ALA PHE GLY
SEQRES 34 E 456 LEU VAL CYS ALA THR CYS GLU GLN ILE ALA ASP SER GLN
SEQRES 35 E 456 HIS ARG SER HIS ARG GLN LEU GLU HIS HIS HIS HIS HIS
SEQRES 36 E 456 HIS
SEQRES 1 F 456 MET PRO PHE ILE THR VAL GLY GLN GLU ASN SER THR SER
SEQRES 2 F 456 ILE ASP LEU TYR TYR GLU ASP HIS GLY THR GLY VAL PRO
SEQRES 3 F 456 VAL VAL LEU ILE HIS GLY PHE PRO LEU SER GLY HIS SER
SEQRES 4 F 456 TRP GLU ARG GLN SER ALA ALA LEU LEU ASP ALA GLY TYR
SEQRES 5 F 456 ARG VAL ILE THR TYR ASP ARG ARG GLY PHE GLY GLN SER
SEQRES 6 F 456 SER GLN PRO THR THR GLY TYR ASP TYR ASP THR PHE ALA
SEQRES 7 F 456 ALA ASP LEU ASN THR VAL LEU GLU THR LEU ASP LEU GLN
SEQRES 8 F 456 ASP ALA VAL LEU VAL GLY PHE SER MET GLY THR GLY GLU
SEQRES 9 F 456 VAL ALA ARG TYR VAL SER SER TYR GLY THR ALA ARG ILE
SEQRES 10 F 456 ALA ALA VAL ALA PHE LEU ALA SER LEU GLU PRO PHE LEU
SEQRES 11 F 456 LEU LYS THR ASP ASP ASN PRO ASP GLY ALA ALA PRO GLN
SEQRES 12 F 456 GLU PHE PHE ASP GLY ILE VAL ALA ALA VAL LYS ALA ASP
SEQRES 13 F 456 ARG TYR ALA PHE TYR THR GLY PHE PHE ASN ASP PHE TYR
SEQRES 14 F 456 ASN LEU ASP GLU ASN LEU GLY THR ARG ILE SER GLU GLU
SEQRES 15 F 456 ALA VAL ARG ASN SER TRP ASN THR ALA ALA SER GLY GLY
SEQRES 16 F 456 PHE PHE ALA ALA ALA ALA ALA PRO THR THR TRP TYR THR
SEQRES 17 F 456 ASP PHE ARG ALA ASP ILE PRO ARG ILE ASP VAL PRO ALA
SEQRES 18 F 456 LEU ILE LEU HIS GLY THR GLY ASP ARG THR LEU PRO ILE
SEQRES 19 F 456 GLU ASN THR ALA ARG VAL PHE HIS LYS ALA LEU PRO SER
SEQRES 20 F 456 ALA GLU TYR VAL GLU VAL GLU GLY ALA PRO HIS GLY LEU
SEQRES 21 F 456 LEU TRP THR HIS ALA GLU GLU VAL ASN THR ALA LEU LEU
SEQRES 22 F 456 ALA PHE LEU ALA LYS ALA LEU GLU ALA GLN LYS GLN LYS
SEQRES 23 F 456 LEU LEU THR GLU VAL GLU THR TYR VAL LEU SER ILE ILE
SEQRES 24 F 456 PRO SER GLY PRO LEU LYS ALA GLU ILE ALA GLN ARG LEU
SEQRES 25 F 456 GLU ASP VAL PHE ALA GLY LYS ASN THR ASP LEU GLU VAL
SEQRES 26 F 456 LEU MET GLU TRP LEU LYS THR ARG PRO ILE LEU SER PRO
SEQRES 27 F 456 LEU THR LYS GLY ILE LEU GLY PHE VAL PHE THR LEU THR
SEQRES 28 F 456 VAL PRO SER GLU ARG GLY LEU GLN ARG ARG ARG PHE VAL
SEQRES 29 F 456 GLN ASN ALA LEU ASN GLY ASN GLY ASP PRO ASN ASN MET
SEQRES 30 F 456 ASP LYS ALA VAL LYS LEU TYR ARG LYS LEU LYS ARG GLU
SEQRES 31 F 456 ILE THR PHE HIS GLY ALA LYS GLU ILE SER LEU SER TYR
SEQRES 32 F 456 SER ALA GLY ALA LEU ALA SER CYS MET GLY LEU ILE TYR
SEQRES 33 F 456 ASN ARG MET GLY ALA VAL THR THR GLU VAL ALA PHE GLY
SEQRES 34 F 456 LEU VAL CYS ALA THR CYS GLU GLN ILE ALA ASP SER GLN
SEQRES 35 F 456 HIS ARG SER HIS ARG GLN LEU GLU HIS HIS HIS HIS HIS
SEQRES 36 F 456 HIS
SEQRES 1 G 456 MET PRO PHE ILE THR VAL GLY GLN GLU ASN SER THR SER
SEQRES 2 G 456 ILE ASP LEU TYR TYR GLU ASP HIS GLY THR GLY VAL PRO
SEQRES 3 G 456 VAL VAL LEU ILE HIS GLY PHE PRO LEU SER GLY HIS SER
SEQRES 4 G 456 TRP GLU ARG GLN SER ALA ALA LEU LEU ASP ALA GLY TYR
SEQRES 5 G 456 ARG VAL ILE THR TYR ASP ARG ARG GLY PHE GLY GLN SER
SEQRES 6 G 456 SER GLN PRO THR THR GLY TYR ASP TYR ASP THR PHE ALA
SEQRES 7 G 456 ALA ASP LEU ASN THR VAL LEU GLU THR LEU ASP LEU GLN
SEQRES 8 G 456 ASP ALA VAL LEU VAL GLY PHE SER MET GLY THR GLY GLU
SEQRES 9 G 456 VAL ALA ARG TYR VAL SER SER TYR GLY THR ALA ARG ILE
SEQRES 10 G 456 ALA ALA VAL ALA PHE LEU ALA SER LEU GLU PRO PHE LEU
SEQRES 11 G 456 LEU LYS THR ASP ASP ASN PRO ASP GLY ALA ALA PRO GLN
SEQRES 12 G 456 GLU PHE PHE ASP GLY ILE VAL ALA ALA VAL LYS ALA ASP
SEQRES 13 G 456 ARG TYR ALA PHE TYR THR GLY PHE PHE ASN ASP PHE TYR
SEQRES 14 G 456 ASN LEU ASP GLU ASN LEU GLY THR ARG ILE SER GLU GLU
SEQRES 15 G 456 ALA VAL ARG ASN SER TRP ASN THR ALA ALA SER GLY GLY
SEQRES 16 G 456 PHE PHE ALA ALA ALA ALA ALA PRO THR THR TRP TYR THR
SEQRES 17 G 456 ASP PHE ARG ALA ASP ILE PRO ARG ILE ASP VAL PRO ALA
SEQRES 18 G 456 LEU ILE LEU HIS GLY THR GLY ASP ARG THR LEU PRO ILE
SEQRES 19 G 456 GLU ASN THR ALA ARG VAL PHE HIS LYS ALA LEU PRO SER
SEQRES 20 G 456 ALA GLU TYR VAL GLU VAL GLU GLY ALA PRO HIS GLY LEU
SEQRES 21 G 456 LEU TRP THR HIS ALA GLU GLU VAL ASN THR ALA LEU LEU
SEQRES 22 G 456 ALA PHE LEU ALA LYS ALA LEU GLU ALA GLN LYS GLN LYS
SEQRES 23 G 456 LEU LEU THR GLU VAL GLU THR TYR VAL LEU SER ILE ILE
SEQRES 24 G 456 PRO SER GLY PRO LEU LYS ALA GLU ILE ALA GLN ARG LEU
SEQRES 25 G 456 GLU ASP VAL PHE ALA GLY LYS ASN THR ASP LEU GLU VAL
SEQRES 26 G 456 LEU MET GLU TRP LEU LYS THR ARG PRO ILE LEU SER PRO
SEQRES 27 G 456 LEU THR LYS GLY ILE LEU GLY PHE VAL PHE THR LEU THR
SEQRES 28 G 456 VAL PRO SER GLU ARG GLY LEU GLN ARG ARG ARG PHE VAL
SEQRES 29 G 456 GLN ASN ALA LEU ASN GLY ASN GLY ASP PRO ASN ASN MET
SEQRES 30 G 456 ASP LYS ALA VAL LYS LEU TYR ARG LYS LEU LYS ARG GLU
SEQRES 31 G 456 ILE THR PHE HIS GLY ALA LYS GLU ILE SER LEU SER TYR
SEQRES 32 G 456 SER ALA GLY ALA LEU ALA SER CYS MET GLY LEU ILE TYR
SEQRES 33 G 456 ASN ARG MET GLY ALA VAL THR THR GLU VAL ALA PHE GLY
SEQRES 34 G 456 LEU VAL CYS ALA THR CYS GLU GLN ILE ALA ASP SER GLN
SEQRES 35 G 456 HIS ARG SER HIS ARG GLN LEU GLU HIS HIS HIS HIS HIS
SEQRES 36 G 456 HIS
SEQRES 1 H 456 MET PRO PHE ILE THR VAL GLY GLN GLU ASN SER THR SER
SEQRES 2 H 456 ILE ASP LEU TYR TYR GLU ASP HIS GLY THR GLY VAL PRO
SEQRES 3 H 456 VAL VAL LEU ILE HIS GLY PHE PRO LEU SER GLY HIS SER
SEQRES 4 H 456 TRP GLU ARG GLN SER ALA ALA LEU LEU ASP ALA GLY TYR
SEQRES 5 H 456 ARG VAL ILE THR TYR ASP ARG ARG GLY PHE GLY GLN SER
SEQRES 6 H 456 SER GLN PRO THR THR GLY TYR ASP TYR ASP THR PHE ALA
SEQRES 7 H 456 ALA ASP LEU ASN THR VAL LEU GLU THR LEU ASP LEU GLN
SEQRES 8 H 456 ASP ALA VAL LEU VAL GLY PHE SER MET GLY THR GLY GLU
SEQRES 9 H 456 VAL ALA ARG TYR VAL SER SER TYR GLY THR ALA ARG ILE
SEQRES 10 H 456 ALA ALA VAL ALA PHE LEU ALA SER LEU GLU PRO PHE LEU
SEQRES 11 H 456 LEU LYS THR ASP ASP ASN PRO ASP GLY ALA ALA PRO GLN
SEQRES 12 H 456 GLU PHE PHE ASP GLY ILE VAL ALA ALA VAL LYS ALA ASP
SEQRES 13 H 456 ARG TYR ALA PHE TYR THR GLY PHE PHE ASN ASP PHE TYR
SEQRES 14 H 456 ASN LEU ASP GLU ASN LEU GLY THR ARG ILE SER GLU GLU
SEQRES 15 H 456 ALA VAL ARG ASN SER TRP ASN THR ALA ALA SER GLY GLY
SEQRES 16 H 456 PHE PHE ALA ALA ALA ALA ALA PRO THR THR TRP TYR THR
SEQRES 17 H 456 ASP PHE ARG ALA ASP ILE PRO ARG ILE ASP VAL PRO ALA
SEQRES 18 H 456 LEU ILE LEU HIS GLY THR GLY ASP ARG THR LEU PRO ILE
SEQRES 19 H 456 GLU ASN THR ALA ARG VAL PHE HIS LYS ALA LEU PRO SER
SEQRES 20 H 456 ALA GLU TYR VAL GLU VAL GLU GLY ALA PRO HIS GLY LEU
SEQRES 21 H 456 LEU TRP THR HIS ALA GLU GLU VAL ASN THR ALA LEU LEU
SEQRES 22 H 456 ALA PHE LEU ALA LYS ALA LEU GLU ALA GLN LYS GLN LYS
SEQRES 23 H 456 LEU LEU THR GLU VAL GLU THR TYR VAL LEU SER ILE ILE
SEQRES 24 H 456 PRO SER GLY PRO LEU LYS ALA GLU ILE ALA GLN ARG LEU
SEQRES 25 H 456 GLU ASP VAL PHE ALA GLY LYS ASN THR ASP LEU GLU VAL
SEQRES 26 H 456 LEU MET GLU TRP LEU LYS THR ARG PRO ILE LEU SER PRO
SEQRES 27 H 456 LEU THR LYS GLY ILE LEU GLY PHE VAL PHE THR LEU THR
SEQRES 28 H 456 VAL PRO SER GLU ARG GLY LEU GLN ARG ARG ARG PHE VAL
SEQRES 29 H 456 GLN ASN ALA LEU ASN GLY ASN GLY ASP PRO ASN ASN MET
SEQRES 30 H 456 ASP LYS ALA VAL LYS LEU TYR ARG LYS LEU LYS ARG GLU
SEQRES 31 H 456 ILE THR PHE HIS GLY ALA LYS GLU ILE SER LEU SER TYR
SEQRES 32 H 456 SER ALA GLY ALA LEU ALA SER CYS MET GLY LEU ILE TYR
SEQRES 33 H 456 ASN ARG MET GLY ALA VAL THR THR GLU VAL ALA PHE GLY
SEQRES 34 H 456 LEU VAL CYS ALA THR CYS GLU GLN ILE ALA ASP SER GLN
SEQRES 35 H 456 HIS ARG SER HIS ARG GLN LEU GLU HIS HIS HIS HIS HIS
SEQRES 36 H 456 HIS
SEQRES 1 I 456 MET PRO PHE ILE THR VAL GLY GLN GLU ASN SER THR SER
SEQRES 2 I 456 ILE ASP LEU TYR TYR GLU ASP HIS GLY THR GLY VAL PRO
SEQRES 3 I 456 VAL VAL LEU ILE HIS GLY PHE PRO LEU SER GLY HIS SER
SEQRES 4 I 456 TRP GLU ARG GLN SER ALA ALA LEU LEU ASP ALA GLY TYR
SEQRES 5 I 456 ARG VAL ILE THR TYR ASP ARG ARG GLY PHE GLY GLN SER
SEQRES 6 I 456 SER GLN PRO THR THR GLY TYR ASP TYR ASP THR PHE ALA
SEQRES 7 I 456 ALA ASP LEU ASN THR VAL LEU GLU THR LEU ASP LEU GLN
SEQRES 8 I 456 ASP ALA VAL LEU VAL GLY PHE SER MET GLY THR GLY GLU
SEQRES 9 I 456 VAL ALA ARG TYR VAL SER SER TYR GLY THR ALA ARG ILE
SEQRES 10 I 456 ALA ALA VAL ALA PHE LEU ALA SER LEU GLU PRO PHE LEU
SEQRES 11 I 456 LEU LYS THR ASP ASP ASN PRO ASP GLY ALA ALA PRO GLN
SEQRES 12 I 456 GLU PHE PHE ASP GLY ILE VAL ALA ALA VAL LYS ALA ASP
SEQRES 13 I 456 ARG TYR ALA PHE TYR THR GLY PHE PHE ASN ASP PHE TYR
SEQRES 14 I 456 ASN LEU ASP GLU ASN LEU GLY THR ARG ILE SER GLU GLU
SEQRES 15 I 456 ALA VAL ARG ASN SER TRP ASN THR ALA ALA SER GLY GLY
SEQRES 16 I 456 PHE PHE ALA ALA ALA ALA ALA PRO THR THR TRP TYR THR
SEQRES 17 I 456 ASP PHE ARG ALA ASP ILE PRO ARG ILE ASP VAL PRO ALA
SEQRES 18 I 456 LEU ILE LEU HIS GLY THR GLY ASP ARG THR LEU PRO ILE
SEQRES 19 I 456 GLU ASN THR ALA ARG VAL PHE HIS LYS ALA LEU PRO SER
SEQRES 20 I 456 ALA GLU TYR VAL GLU VAL GLU GLY ALA PRO HIS GLY LEU
SEQRES 21 I 456 LEU TRP THR HIS ALA GLU GLU VAL ASN THR ALA LEU LEU
SEQRES 22 I 456 ALA PHE LEU ALA LYS ALA LEU GLU ALA GLN LYS GLN LYS
SEQRES 23 I 456 LEU LEU THR GLU VAL GLU THR TYR VAL LEU SER ILE ILE
SEQRES 24 I 456 PRO SER GLY PRO LEU LYS ALA GLU ILE ALA GLN ARG LEU
SEQRES 25 I 456 GLU ASP VAL PHE ALA GLY LYS ASN THR ASP LEU GLU VAL
SEQRES 26 I 456 LEU MET GLU TRP LEU LYS THR ARG PRO ILE LEU SER PRO
SEQRES 27 I 456 LEU THR LYS GLY ILE LEU GLY PHE VAL PHE THR LEU THR
SEQRES 28 I 456 VAL PRO SER GLU ARG GLY LEU GLN ARG ARG ARG PHE VAL
SEQRES 29 I 456 GLN ASN ALA LEU ASN GLY ASN GLY ASP PRO ASN ASN MET
SEQRES 30 I 456 ASP LYS ALA VAL LYS LEU TYR ARG LYS LEU LYS ARG GLU
SEQRES 31 I 456 ILE THR PHE HIS GLY ALA LYS GLU ILE SER LEU SER TYR
SEQRES 32 I 456 SER ALA GLY ALA LEU ALA SER CYS MET GLY LEU ILE TYR
SEQRES 33 I 456 ASN ARG MET GLY ALA VAL THR THR GLU VAL ALA PHE GLY
SEQRES 34 I 456 LEU VAL CYS ALA THR CYS GLU GLN ILE ALA ASP SER GLN
SEQRES 35 I 456 HIS ARG SER HIS ARG GLN LEU GLU HIS HIS HIS HIS HIS
SEQRES 36 I 456 HIS
SEQRES 1 J 456 MET PRO PHE ILE THR VAL GLY GLN GLU ASN SER THR SER
SEQRES 2 J 456 ILE ASP LEU TYR TYR GLU ASP HIS GLY THR GLY VAL PRO
SEQRES 3 J 456 VAL VAL LEU ILE HIS GLY PHE PRO LEU SER GLY HIS SER
SEQRES 4 J 456 TRP GLU ARG GLN SER ALA ALA LEU LEU ASP ALA GLY TYR
SEQRES 5 J 456 ARG VAL ILE THR TYR ASP ARG ARG GLY PHE GLY GLN SER
SEQRES 6 J 456 SER GLN PRO THR THR GLY TYR ASP TYR ASP THR PHE ALA
SEQRES 7 J 456 ALA ASP LEU ASN THR VAL LEU GLU THR LEU ASP LEU GLN
SEQRES 8 J 456 ASP ALA VAL LEU VAL GLY PHE SER MET GLY THR GLY GLU
SEQRES 9 J 456 VAL ALA ARG TYR VAL SER SER TYR GLY THR ALA ARG ILE
SEQRES 10 J 456 ALA ALA VAL ALA PHE LEU ALA SER LEU GLU PRO PHE LEU
SEQRES 11 J 456 LEU LYS THR ASP ASP ASN PRO ASP GLY ALA ALA PRO GLN
SEQRES 12 J 456 GLU PHE PHE ASP GLY ILE VAL ALA ALA VAL LYS ALA ASP
SEQRES 13 J 456 ARG TYR ALA PHE TYR THR GLY PHE PHE ASN ASP PHE TYR
SEQRES 14 J 456 ASN LEU ASP GLU ASN LEU GLY THR ARG ILE SER GLU GLU
SEQRES 15 J 456 ALA VAL ARG ASN SER TRP ASN THR ALA ALA SER GLY GLY
SEQRES 16 J 456 PHE PHE ALA ALA ALA ALA ALA PRO THR THR TRP TYR THR
SEQRES 17 J 456 ASP PHE ARG ALA ASP ILE PRO ARG ILE ASP VAL PRO ALA
SEQRES 18 J 456 LEU ILE LEU HIS GLY THR GLY ASP ARG THR LEU PRO ILE
SEQRES 19 J 456 GLU ASN THR ALA ARG VAL PHE HIS LYS ALA LEU PRO SER
SEQRES 20 J 456 ALA GLU TYR VAL GLU VAL GLU GLY ALA PRO HIS GLY LEU
SEQRES 21 J 456 LEU TRP THR HIS ALA GLU GLU VAL ASN THR ALA LEU LEU
SEQRES 22 J 456 ALA PHE LEU ALA LYS ALA LEU GLU ALA GLN LYS GLN LYS
SEQRES 23 J 456 LEU LEU THR GLU VAL GLU THR TYR VAL LEU SER ILE ILE
SEQRES 24 J 456 PRO SER GLY PRO LEU LYS ALA GLU ILE ALA GLN ARG LEU
SEQRES 25 J 456 GLU ASP VAL PHE ALA GLY LYS ASN THR ASP LEU GLU VAL
SEQRES 26 J 456 LEU MET GLU TRP LEU LYS THR ARG PRO ILE LEU SER PRO
SEQRES 27 J 456 LEU THR LYS GLY ILE LEU GLY PHE VAL PHE THR LEU THR
SEQRES 28 J 456 VAL PRO SER GLU ARG GLY LEU GLN ARG ARG ARG PHE VAL
SEQRES 29 J 456 GLN ASN ALA LEU ASN GLY ASN GLY ASP PRO ASN ASN MET
SEQRES 30 J 456 ASP LYS ALA VAL LYS LEU TYR ARG LYS LEU LYS ARG GLU
SEQRES 31 J 456 ILE THR PHE HIS GLY ALA LYS GLU ILE SER LEU SER TYR
SEQRES 32 J 456 SER ALA GLY ALA LEU ALA SER CYS MET GLY LEU ILE TYR
SEQRES 33 J 456 ASN ARG MET GLY ALA VAL THR THR GLU VAL ALA PHE GLY
SEQRES 34 J 456 LEU VAL CYS ALA THR CYS GLU GLN ILE ALA ASP SER GLN
SEQRES 35 J 456 HIS ARG SER HIS ARG GLN LEU GLU HIS HIS HIS HIS HIS
SEQRES 36 J 456 HIS
SEQRES 1 K 456 MET PRO PHE ILE THR VAL GLY GLN GLU ASN SER THR SER
SEQRES 2 K 456 ILE ASP LEU TYR TYR GLU ASP HIS GLY THR GLY VAL PRO
SEQRES 3 K 456 VAL VAL LEU ILE HIS GLY PHE PRO LEU SER GLY HIS SER
SEQRES 4 K 456 TRP GLU ARG GLN SER ALA ALA LEU LEU ASP ALA GLY TYR
SEQRES 5 K 456 ARG VAL ILE THR TYR ASP ARG ARG GLY PHE GLY GLN SER
SEQRES 6 K 456 SER GLN PRO THR THR GLY TYR ASP TYR ASP THR PHE ALA
SEQRES 7 K 456 ALA ASP LEU ASN THR VAL LEU GLU THR LEU ASP LEU GLN
SEQRES 8 K 456 ASP ALA VAL LEU VAL GLY PHE SER MET GLY THR GLY GLU
SEQRES 9 K 456 VAL ALA ARG TYR VAL SER SER TYR GLY THR ALA ARG ILE
SEQRES 10 K 456 ALA ALA VAL ALA PHE LEU ALA SER LEU GLU PRO PHE LEU
SEQRES 11 K 456 LEU LYS THR ASP ASP ASN PRO ASP GLY ALA ALA PRO GLN
SEQRES 12 K 456 GLU PHE PHE ASP GLY ILE VAL ALA ALA VAL LYS ALA ASP
SEQRES 13 K 456 ARG TYR ALA PHE TYR THR GLY PHE PHE ASN ASP PHE TYR
SEQRES 14 K 456 ASN LEU ASP GLU ASN LEU GLY THR ARG ILE SER GLU GLU
SEQRES 15 K 456 ALA VAL ARG ASN SER TRP ASN THR ALA ALA SER GLY GLY
SEQRES 16 K 456 PHE PHE ALA ALA ALA ALA ALA PRO THR THR TRP TYR THR
SEQRES 17 K 456 ASP PHE ARG ALA ASP ILE PRO ARG ILE ASP VAL PRO ALA
SEQRES 18 K 456 LEU ILE LEU HIS GLY THR GLY ASP ARG THR LEU PRO ILE
SEQRES 19 K 456 GLU ASN THR ALA ARG VAL PHE HIS LYS ALA LEU PRO SER
SEQRES 20 K 456 ALA GLU TYR VAL GLU VAL GLU GLY ALA PRO HIS GLY LEU
SEQRES 21 K 456 LEU TRP THR HIS ALA GLU GLU VAL ASN THR ALA LEU LEU
SEQRES 22 K 456 ALA PHE LEU ALA LYS ALA LEU GLU ALA GLN LYS GLN LYS
SEQRES 23 K 456 LEU LEU THR GLU VAL GLU THR TYR VAL LEU SER ILE ILE
SEQRES 24 K 456 PRO SER GLY PRO LEU LYS ALA GLU ILE ALA GLN ARG LEU
SEQRES 25 K 456 GLU ASP VAL PHE ALA GLY LYS ASN THR ASP LEU GLU VAL
SEQRES 26 K 456 LEU MET GLU TRP LEU LYS THR ARG PRO ILE LEU SER PRO
SEQRES 27 K 456 LEU THR LYS GLY ILE LEU GLY PHE VAL PHE THR LEU THR
SEQRES 28 K 456 VAL PRO SER GLU ARG GLY LEU GLN ARG ARG ARG PHE VAL
SEQRES 29 K 456 GLN ASN ALA LEU ASN GLY ASN GLY ASP PRO ASN ASN MET
SEQRES 30 K 456 ASP LYS ALA VAL LYS LEU TYR ARG LYS LEU LYS ARG GLU
SEQRES 31 K 456 ILE THR PHE HIS GLY ALA LYS GLU ILE SER LEU SER TYR
SEQRES 32 K 456 SER ALA GLY ALA LEU ALA SER CYS MET GLY LEU ILE TYR
SEQRES 33 K 456 ASN ARG MET GLY ALA VAL THR THR GLU VAL ALA PHE GLY
SEQRES 34 K 456 LEU VAL CYS ALA THR CYS GLU GLN ILE ALA ASP SER GLN
SEQRES 35 K 456 HIS ARG SER HIS ARG GLN LEU GLU HIS HIS HIS HIS HIS
SEQRES 36 K 456 HIS
SEQRES 1 L 456 MET PRO PHE ILE THR VAL GLY GLN GLU ASN SER THR SER
SEQRES 2 L 456 ILE ASP LEU TYR TYR GLU ASP HIS GLY THR GLY VAL PRO
SEQRES 3 L 456 VAL VAL LEU ILE HIS GLY PHE PRO LEU SER GLY HIS SER
SEQRES 4 L 456 TRP GLU ARG GLN SER ALA ALA LEU LEU ASP ALA GLY TYR
SEQRES 5 L 456 ARG VAL ILE THR TYR ASP ARG ARG GLY PHE GLY GLN SER
SEQRES 6 L 456 SER GLN PRO THR THR GLY TYR ASP TYR ASP THR PHE ALA
SEQRES 7 L 456 ALA ASP LEU ASN THR VAL LEU GLU THR LEU ASP LEU GLN
SEQRES 8 L 456 ASP ALA VAL LEU VAL GLY PHE SER MET GLY THR GLY GLU
SEQRES 9 L 456 VAL ALA ARG TYR VAL SER SER TYR GLY THR ALA ARG ILE
SEQRES 10 L 456 ALA ALA VAL ALA PHE LEU ALA SER LEU GLU PRO PHE LEU
SEQRES 11 L 456 LEU LYS THR ASP ASP ASN PRO ASP GLY ALA ALA PRO GLN
SEQRES 12 L 456 GLU PHE PHE ASP GLY ILE VAL ALA ALA VAL LYS ALA ASP
SEQRES 13 L 456 ARG TYR ALA PHE TYR THR GLY PHE PHE ASN ASP PHE TYR
SEQRES 14 L 456 ASN LEU ASP GLU ASN LEU GLY THR ARG ILE SER GLU GLU
SEQRES 15 L 456 ALA VAL ARG ASN SER TRP ASN THR ALA ALA SER GLY GLY
SEQRES 16 L 456 PHE PHE ALA ALA ALA ALA ALA PRO THR THR TRP TYR THR
SEQRES 17 L 456 ASP PHE ARG ALA ASP ILE PRO ARG ILE ASP VAL PRO ALA
SEQRES 18 L 456 LEU ILE LEU HIS GLY THR GLY ASP ARG THR LEU PRO ILE
SEQRES 19 L 456 GLU ASN THR ALA ARG VAL PHE HIS LYS ALA LEU PRO SER
SEQRES 20 L 456 ALA GLU TYR VAL GLU VAL GLU GLY ALA PRO HIS GLY LEU
SEQRES 21 L 456 LEU TRP THR HIS ALA GLU GLU VAL ASN THR ALA LEU LEU
SEQRES 22 L 456 ALA PHE LEU ALA LYS ALA LEU GLU ALA GLN LYS GLN LYS
SEQRES 23 L 456 LEU LEU THR GLU VAL GLU THR TYR VAL LEU SER ILE ILE
SEQRES 24 L 456 PRO SER GLY PRO LEU LYS ALA GLU ILE ALA GLN ARG LEU
SEQRES 25 L 456 GLU ASP VAL PHE ALA GLY LYS ASN THR ASP LEU GLU VAL
SEQRES 26 L 456 LEU MET GLU TRP LEU LYS THR ARG PRO ILE LEU SER PRO
SEQRES 27 L 456 LEU THR LYS GLY ILE LEU GLY PHE VAL PHE THR LEU THR
SEQRES 28 L 456 VAL PRO SER GLU ARG GLY LEU GLN ARG ARG ARG PHE VAL
SEQRES 29 L 456 GLN ASN ALA LEU ASN GLY ASN GLY ASP PRO ASN ASN MET
SEQRES 30 L 456 ASP LYS ALA VAL LYS LEU TYR ARG LYS LEU LYS ARG GLU
SEQRES 31 L 456 ILE THR PHE HIS GLY ALA LYS GLU ILE SER LEU SER TYR
SEQRES 32 L 456 SER ALA GLY ALA LEU ALA SER CYS MET GLY LEU ILE TYR
SEQRES 33 L 456 ASN ARG MET GLY ALA VAL THR THR GLU VAL ALA PHE GLY
SEQRES 34 L 456 LEU VAL CYS ALA THR CYS GLU GLN ILE ALA ASP SER GLN
SEQRES 35 L 456 HIS ARG SER HIS ARG GLN LEU GLU HIS HIS HIS HIS HIS
SEQRES 36 L 456 HIS
HELIX 1 1 SER A 35 SER A 38 5 4
HELIX 2 2 TRP A 39 GLY A 50 1 12
HELIX 3 3 ASP A 72 ASP A 88 1 17
HELIX 4 4 MET A 99 GLY A 112 1 14
HELIX 5 5 PRO A 141 TYR A 168 1 28
HELIX 6 6 ASN A 169 LEU A 174 1 6
HELIX 7 7 SER A 179 SER A 192 1 14
HELIX 8 8 GLY A 194 ALA A 201 1 8
HELIX 9 9 PRO A 202 TRP A 205 5 4
HELIX 10 10 ASP A 212 ILE A 216 5 5
HELIX 11 11 PRO A 232 ASN A 235 5 4
HELIX 12 12 THR A 236 LEU A 244 1 9
HELIX 13 13 HIS A 263 LEU A 279 1 17
HELIX 14 14 LEU A 279 LEU A 295 1 17
HELIX 15 15 GLY A 301 GLY A 317 1 17
HELIX 16 16 ASP A 321 THR A 331 1 11
HELIX 17 17 SER A 336 VAL A 351 1 16
HELIX 18 18 ARG A 361 LEU A 367 1 7
HELIX 19 19 ASP A 372 ARG A 388 1 17
HELIX 20 20 THR A 391 SER A 399 1 9
HELIX 21 21 SER A 403 ASN A 416 1 14
HELIX 22 22 THR A 422 ALA A 438 1 17
HELIX 23 23 SER B 35 SER B 38 5 4
HELIX 24 24 TRP B 39 GLY B 50 1 12
HELIX 25 25 ASP B 72 ASP B 88 1 17
HELIX 26 26 MET B 99 GLY B 112 1 14
HELIX 27 27 PRO B 141 ASP B 155 1 15
HELIX 28 28 ASP B 155 TYR B 168 1 14
HELIX 29 29 ASN B 169 LEU B 174 1 6
HELIX 30 30 SER B 179 SER B 192 1 14
HELIX 31 31 GLY B 194 ALA B 201 1 8
HELIX 32 32 PRO B 202 TRP B 205 5 4
HELIX 33 33 ASP B 212 ILE B 216 5 5
HELIX 34 34 PRO B 232 ASN B 235 5 4
HELIX 35 35 THR B 236 LEU B 244 1 9
HELIX 36 36 HIS B 263 SER B 296 1 34
HELIX 37 37 GLY B 301 GLY B 317 1 17
HELIX 38 38 ASP B 321 THR B 331 1 11
HELIX 39 39 SER B 336 VAL B 351 1 16
HELIX 40 40 ARG B 361 LEU B 367 1 7
HELIX 41 41 ASP B 372 LYS B 387 1 16
HELIX 42 42 THR B 391 SER B 399 1 9
HELIX 43 43 SER B 403 ARG B 417 1 15
HELIX 44 44 THR B 422 ILE B 437 1 16
HELIX 45 45 SER C 35 SER C 38 5 4
HELIX 46 46 TRP C 39 GLY C 50 1 12
HELIX 47 47 ASP C 72 ASP C 88 1 17
HELIX 48 48 MET C 99 GLY C 112 1 14
HELIX 49 49 PRO C 141 ASP C 155 1 15
HELIX 50 50 ASP C 155 TYR C 168 1 14
HELIX 51 51 ASN C 169 LEU C 174 1 6
HELIX 52 52 SER C 179 SER C 192 1 14
HELIX 53 53 GLY C 194 ALA C 201 1 8
HELIX 54 54 PRO C 202 TRP C 205 5 4
HELIX 55 55 ASP C 212 ILE C 216 5 5
HELIX 56 56 PRO C 232 ASN C 235 5 4
HELIX 57 57 THR C 236 LEU C 244 1 9
HELIX 58 58 HIS C 263 LEU C 279 1 17
HELIX 59 59 LEU C 279 LEU C 295 1 17
HELIX 60 60 GLY C 301 ALA C 316 1 16
HELIX 61 61 ASP C 321 THR C 331 1 11
HELIX 62 62 SER C 336 VAL C 351 1 16
HELIX 63 63 ARG C 361 LEU C 367 1 7
HELIX 64 64 ASP C 372 LYS C 387 1 16
HELIX 65 65 THR C 391 SER C 399 1 9
HELIX 66 66 SER C 403 ASN C 416 1 14
HELIX 67 67 THR C 422 ILE C 437 1 16
HELIX 68 68 SER D 35 SER D 38 5 4
HELIX 69 69 TRP D 39 GLY D 50 1 12
HELIX 70 70 ASP D 72 ASP D 88 1 17
HELIX 71 71 MET D 99 GLY D 112 1 14
HELIX 72 72 PRO D 141 TYR D 168 1 28
HELIX 73 73 ASN D 169 LEU D 174 1 6
HELIX 74 74 SER D 179 SER D 192 1 14
HELIX 75 75 GLY D 194 ALA D 201 1 8
HELIX 76 76 PRO D 202 TRP D 205 5 4
HELIX 77 77 ASP D 212 ILE D 216 5 5
HELIX 78 78 PRO D 232 ASN D 235 5 4
HELIX 79 79 THR D 236 LEU D 244 1 9
HELIX 80 80 HIS D 263 LEU D 279 1 17
HELIX 81 81 LEU D 279 LEU D 295 1 17
HELIX 82 82 GLY D 301 ALA D 316 1 16
HELIX 83 83 ASP D 321 THR D 331 1 11
HELIX 84 84 SER D 336 VAL D 351 1 16
HELIX 85 85 ARG D 361 GLY D 369 1 9
HELIX 86 86 ASP D 372 ARG D 388 1 17
HELIX 87 87 THR D 391 SER D 399 1 9
HELIX 88 88 SER D 403 ASN D 416 1 14
HELIX 89 89 THR D 422 ILE D 437 1 16
HELIX 90 90 SER E 35 SER E 38 5 4
HELIX 91 91 TRP E 39 GLY E 50 1 12
HELIX 92 92 ASP E 72 ASP E 88 1 17
HELIX 93 93 MET E 99 GLY E 112 1 14
HELIX 94 94 PRO E 141 TYR E 168 1 28
HELIX 95 95 ASN E 169 LEU E 174 1 6
HELIX 96 96 SER E 179 SER E 192 1 14
HELIX 97 97 GLY E 194 ALA E 201 1 8
HELIX 98 98 PRO E 202 TRP E 205 5 4
HELIX 99 99 ASP E 212 ILE E 216 5 5
HELIX 100 100 PRO E 232 ASN E 235 5 4
HELIX 101 101 THR E 236 LEU E 244 1 9
HELIX 102 102 HIS E 263 LEU E 295 1 33
HELIX 103 103 GLY E 301 GLY E 317 1 17
HELIX 104 104 ASP E 321 THR E 331 1 11
HELIX 105 105 SER E 336 VAL E 351 1 16
HELIX 106 106 ASP E 372 LYS E 387 1 16
HELIX 107 107 THR E 391 SER E 399 1 9
HELIX 108 108 SER E 403 ARG E 417 1 15
HELIX 109 109 THR E 422 ILE E 437 1 16
HELIX 110 110 SER F 35 SER F 38 5 4
HELIX 111 111 TRP F 39 GLY F 50 1 12
HELIX 112 112 ASP F 72 ASP F 88 1 17
HELIX 113 113 MET F 99 GLY F 112 1 14
HELIX 114 114 PRO F 141 TYR F 168 1 28
HELIX 115 115 ASN F 169 LEU F 174 1 6
HELIX 116 116 SER F 179 SER F 192 1 14
HELIX 117 117 GLY F 194 ALA F 201 1 8
HELIX 118 118 PRO F 202 TRP F 205 5 4
HELIX 119 119 ASP F 212 ILE F 216 5 5
HELIX 120 120 PRO F 232 ASN F 235 5 4
HELIX 121 121 THR F 236 LEU F 244 1 9
HELIX 122 122 HIS F 263 LEU F 279 1 17
HELIX 123 123 LEU F 279 LEU F 295 1 17
HELIX 124 124 GLY F 301 ALA F 316 1 16
HELIX 125 125 ASP F 321 THR F 331 1 11
HELIX 126 126 SER F 336 VAL F 351 1 16
HELIX 127 127 ARG F 361 LEU F 367 1 7
HELIX 128 128 ASP F 372 ARG F 388 1 17
HELIX 129 129 THR F 391 SER F 399 1 9
HELIX 130 130 SER F 403 ASN F 416 1 14
HELIX 131 131 THR F 422 ILE F 437 1 16
HELIX 132 132 SER G 35 SER G 38 5 4
HELIX 133 133 TRP G 39 GLY G 50 1 12
HELIX 134 134 ASP G 72 ASP G 88 1 17
HELIX 135 135 MET G 99 GLY G 112 1 14
HELIX 136 136 PRO G 141 TYR G 168 1 28
HELIX 137 137 ASN G 169 LEU G 174 1 6
HELIX 138 138 SER G 179 SER G 192 1 14
HELIX 139 139 GLY G 194 ALA G 201 1 8
HELIX 140 140 ALA G 201 TYR G 206 1 6
HELIX 141 141 ASP G 212 ILE G 216 5 5
HELIX 142 142 PRO G 232 ASN G 235 5 4
HELIX 143 143 THR G 236 LEU G 244 1 9
HELIX 144 144 HIS G 263 LEU G 279 1 17
HELIX 145 145 LEU G 279 LEU G 295 1 17
HELIX 146 146 GLY G 301 ALA G 316 1 16
HELIX 147 147 ASP G 321 THR G 331 1 11
HELIX 148 148 SER G 336 VAL G 351 1 16
HELIX 149 149 ARG G 361 LEU G 367 1 7
HELIX 150 150 ASP G 372 ARG G 388 1 17
HELIX 151 151 THR G 391 SER G 399 1 9
HELIX 152 152 SER G 403 ASN G 416 1 14
HELIX 153 153 THR G 422 ILE G 437 1 16
HELIX 154 154 SER H 35 SER H 38 5 4
HELIX 155 155 TRP H 39 GLY H 50 1 12
HELIX 156 156 ASP H 72 ASP H 88 1 17
HELIX 157 157 MET H 99 GLY H 112 1 14
HELIX 158 158 PRO H 141 ASP H 155 1 15
HELIX 159 159 ASP H 155 TYR H 168 1 14
HELIX 160 160 ASN H 169 LEU H 174 1 6
HELIX 161 161 SER H 179 SER H 192 1 14
HELIX 162 162 GLY H 194 ALA H 201 1 8
HELIX 163 163 PRO H 202 TRP H 205 5 4
HELIX 164 164 ASP H 212 ILE H 216 5 5
HELIX 165 165 PRO H 232 ASN H 235 5 4
HELIX 166 166 THR H 236 LEU H 244 1 9
HELIX 167 167 HIS H 263 LEU H 295 1 33
HELIX 168 168 GLY H 301 GLY H 317 1 17
HELIX 169 169 ASP H 321 THR H 331 1 11
HELIX 170 170 SER H 336 VAL H 351 1 16
HELIX 171 171 ARG H 361 LEU H 367 1 7
HELIX 172 172 ASP H 372 LYS H 387 1 16
HELIX 173 173 THR H 391 SER H 399 1 9
HELIX 174 174 SER H 403 ARG H 417 1 15
HELIX 175 175 THR H 422 ILE H 437 1 16
HELIX 176 176 SER I 35 SER I 38 5 4
HELIX 177 177 TRP I 39 GLY I 50 1 12
HELIX 178 178 ASP I 72 ASP I 88 1 17
HELIX 179 179 MET I 99 GLY I 112 1 14
HELIX 180 180 PRO I 141 ASP I 155 1 15
HELIX 181 181 ASP I 155 TYR I 168 1 14
HELIX 182 182 ASN I 169 LEU I 174 1 6
HELIX 183 183 SER I 179 SER I 192 1 14
HELIX 184 184 PHE I 196 ALA I 201 1 6
HELIX 185 185 PRO I 202 TRP I 205 5 4
HELIX 186 186 ASP I 212 ILE I 216 5 5
HELIX 187 187 PRO I 232 ASN I 235 5 4
HELIX 188 188 THR I 236 LEU I 244 1 9
HELIX 189 189 HIS I 263 LEU I 279 1 17
HELIX 190 190 LEU I 279 LEU I 295 1 17
HELIX 191 191 GLY I 301 GLY I 317 1 17
HELIX 192 192 ASP I 321 THR I 331 1 11
HELIX 193 193 SER I 336 VAL I 351 1 16
HELIX 194 194 ARG I 361 LEU I 367 1 7
HELIX 195 195 ASP I 372 ARG I 388 1 17
HELIX 196 196 THR I 391 SER I 399 1 9
HELIX 197 197 SER I 403 ASN I 416 1 14
HELIX 198 198 THR I 422 ILE I 437 1 16
HELIX 199 199 SER J 35 SER J 38 5 4
HELIX 200 200 TRP J 39 GLY J 50 1 12
HELIX 201 201 ASP J 72 ASP J 88 1 17
HELIX 202 202 MET J 99 GLY J 112 1 14
HELIX 203 203 PRO J 141 ASP J 155 1 15
HELIX 204 204 ASP J 155 TYR J 168 1 14
HELIX 205 205 ASN J 169 LEU J 174 1 6
HELIX 206 206 SER J 179 SER J 192 1 14
HELIX 207 207 GLY J 194 ALA J 201 1 8
HELIX 208 208 PRO J 202 TRP J 205 5 4
HELIX 209 209 ASP J 212 ILE J 216 5 5
HELIX 210 210 PRO J 232 ASN J 235 5 4
HELIX 211 211 THR J 236 LEU J 244 1 9
HELIX 212 212 HIS J 263 LEU J 295 1 33
HELIX 213 213 GLY J 301 ALA J 316 1 16
HELIX 214 214 ASP J 321 THR J 331 1 11
HELIX 215 215 SER J 336 VAL J 351 1 16
HELIX 216 216 ARG J 361 LEU J 367 1 7
HELIX 217 217 ASP J 372 LYS J 387 1 16
HELIX 218 218 THR J 391 SER J 399 1 9
HELIX 219 219 SER J 403 ARG J 417 1 15
HELIX 220 220 THR J 422 ILE J 437 1 16
HELIX 221 221 SER K 35 SER K 38 5 4
HELIX 222 222 TRP K 39 GLY K 50 1 12
HELIX 223 223 ASP K 72 ASP K 88 1 17
HELIX 224 224 MET K 99 GLY K 112 1 14
HELIX 225 225 PRO K 141 ASP K 155 1 15
HELIX 226 226 ASP K 155 TYR K 168 1 14
HELIX 227 227 ASN K 169 LEU K 174 1 6
HELIX 228 228 SER K 179 SER K 192 1 14
HELIX 229 229 PHE K 196 ALA K 201 1 6
HELIX 230 230 PRO K 202 TRP K 205 5 4
HELIX 231 231 ASP K 212 ILE K 216 5 5
HELIX 232 232 PRO K 232 ASN K 235 5 4
HELIX 233 233 THR K 236 LEU K 244 1 9
HELIX 234 234 HIS K 263 LEU K 279 1 17
HELIX 235 235 LEU K 279 LEU K 295 1 17
HELIX 236 236 PRO K 302 ALA K 316 1 15
HELIX 237 237 ASP K 321 THR K 331 1 11
HELIX 238 238 SER K 336 VAL K 351 1 16
HELIX 239 239 ARG K 361 LEU K 367 1 7
HELIX 240 240 ASP K 372 ARG K 388 1 17
HELIX 241 241 THR K 391 SER K 399 1 9
HELIX 242 242 SER K 403 ASN K 416 1 14
HELIX 243 243 THR K 422 ILE K 437 1 16
HELIX 244 244 SER L 35 SER L 38 5 4
HELIX 245 245 TRP L 39 GLY L 50 1 12
HELIX 246 246 ASP L 72 ASP L 88 1 17
HELIX 247 247 MET L 99 GLY L 112 1 14
HELIX 248 248 PRO L 141 ASP L 155 1 15
HELIX 249 249 ASP L 155 TYR L 168 1 14
HELIX 250 250 ASN L 169 LEU L 174 1 6
HELIX 251 251 SER L 179 SER L 192 1 14
HELIX 252 252 GLY L 194 ALA L 201 1 8
HELIX 253 253 PRO L 202 TRP L 205 5 4
HELIX 254 254 ASP L 212 ILE L 216 5 5
HELIX 255 255 PRO L 232 ASN L 235 5 4
HELIX 256 256 THR L 236 LEU L 244 1 9
HELIX 257 257 HIS L 263 LEU L 295 1 33
HELIX 258 258 PRO L 302 GLY L 317 1 16
HELIX 259 259 ASP L 321 THR L 331 1 11
HELIX 260 260 SER L 336 VAL L 351 1 16
HELIX 261 261 ARG L 361 LEU L 367 1 7
HELIX 262 262 ASP L 372 ARG L 388 1 17
HELIX 263 263 THR L 391 SER L 399 1 9
HELIX 264 264 SER L 403 ASN L 416 1 14
HELIX 265 265 THR L 422 ILE L 437 1 16
SHEET 1 A 8 PHE A 2 THR A 4 0
SHEET 2 A 8 ASP A 14 HIS A 20 -1 O LEU A 15 N ILE A 3
SHEET 3 A 8 ARG A 52 TYR A 56 -1 O THR A 55 N GLU A 18
SHEET 4 A 8 PRO A 25 ILE A 29 1 N VAL A 26 O ARG A 52
SHEET 5 A 8 ALA A 92 PHE A 97 1 O VAL A 95 N ILE A 29
SHEET 6 A 8 ILE A 116 LEU A 122 1 O ALA A 117 N ALA A 92
SHEET 7 A 8 ALA A 220 GLY A 225 1 O LEU A 221 N PHE A 121
SHEET 8 A 8 GLU A 248 VAL A 252 1 O GLU A 248 N ILE A 222
SHEET 1 B 8 PHE B 2 THR B 4 0
SHEET 2 B 8 ASP B 14 HIS B 20 -1 O LEU B 15 N ILE B 3
SHEET 3 B 8 ARG B 52 TYR B 56 -1 O THR B 55 N GLU B 18
SHEET 4 B 8 PRO B 25 ILE B 29 1 N VAL B 26 O ARG B 52
SHEET 5 B 8 ALA B 92 PHE B 97 1 O VAL B 95 N VAL B 27
SHEET 6 B 8 ILE B 116 LEU B 122 1 O ALA B 117 N ALA B 92
SHEET 7 B 8 ALA B 220 GLY B 225 1 O LEU B 221 N PHE B 121
SHEET 8 B 8 GLU B 248 VAL B 252 1 O VAL B 250 N ILE B 222
SHEET 1 C 8 PHE C 2 GLU C 8 0
SHEET 2 C 8 THR C 11 HIS C 20 -1 O ILE C 13 N VAL C 5
SHEET 3 C 8 ARG C 52 TYR C 56 -1 O VAL C 53 N HIS C 20
SHEET 4 C 8 PRO C 25 ILE C 29 1 N VAL C 26 O ARG C 52
SHEET 5 C 8 ALA C 92 PHE C 97 1 O VAL C 95 N ILE C 29
SHEET 6 C 8 ILE C 116 LEU C 122 1 O ALA C 117 N ALA C 92
SHEET 7 C 8 ALA C 220 GLY C 225 1 O LEU C 221 N PHE C 121
SHEET 8 C 8 GLU C 248 VAL C 252 1 O VAL C 250 N ILE C 222
SHEET 1 D 8 PHE D 2 THR D 4 0
SHEET 2 D 8 ASP D 14 HIS D 20 -1 O LEU D 15 N ILE D 3
SHEET 3 D 8 ARG D 52 TYR D 56 -1 O THR D 55 N GLU D 18
SHEET 4 D 8 PRO D 25 ILE D 29 1 N VAL D 26 O ARG D 52
SHEET 5 D 8 ALA D 92 PHE D 97 1 O VAL D 95 N ILE D 29
SHEET 6 D 8 ILE D 116 LEU D 122 1 O ALA D 117 N ALA D 92
SHEET 7 D 8 LEU D 221 GLY D 225 1 O LEU D 221 N PHE D 121
SHEET 8 D 8 GLU D 248 VAL D 252 1 O GLU D 248 N ILE D 222
SHEET 1 E 8 PHE E 2 GLU E 8 0
SHEET 2 E 8 THR E 11 HIS E 20 -1 O ILE E 13 N VAL E 5
SHEET 3 E 8 ARG E 52 TYR E 56 -1 O THR E 55 N GLU E 18
SHEET 4 E 8 PRO E 25 ILE E 29 1 N VAL E 26 O ARG E 52
SHEET 5 E 8 ALA E 92 PHE E 97 1 O VAL E 95 N ILE E 29
SHEET 6 E 8 ILE E 116 LEU E 122 1 O ALA E 117 N ALA E 92
SHEET 7 E 8 LEU E 221 GLY E 225 1 O LEU E 221 N PHE E 121
SHEET 8 E 8 GLU E 248 VAL E 252 1 O GLU E 248 N ILE E 222
SHEET 1 F 8 PHE F 2 THR F 4 0
SHEET 2 F 8 ASP F 14 HIS F 20 -1 O LEU F 15 N ILE F 3
SHEET 3 F 8 ARG F 52 TYR F 56 -1 O THR F 55 N GLU F 18
SHEET 4 F 8 PRO F 25 ILE F 29 1 N VAL F 26 O ARG F 52
SHEET 5 F 8 ALA F 92 PHE F 97 1 O VAL F 93 N VAL F 27
SHEET 6 F 8 ILE F 116 LEU F 122 1 O ALA F 117 N ALA F 92
SHEET 7 F 8 LEU F 221 GLY F 225 1 O LEU F 221 N PHE F 121
SHEET 8 F 8 GLU F 248 VAL F 252 1 O GLU F 248 N ILE F 222
SHEET 1 G 8 PHE G 2 THR G 4 0
SHEET 2 G 8 ASP G 14 HIS G 20 -1 O LEU G 15 N ILE G 3
SHEET 3 G 8 ARG G 52 TYR G 56 -1 O THR G 55 N GLU G 18
SHEET 4 G 8 PRO G 25 ILE G 29 1 N VAL G 26 O ARG G 52
SHEET 5 G 8 ALA G 92 PHE G 97 1 O VAL G 95 N VAL G 27
SHEET 6 G 8 ILE G 116 LEU G 122 1 O ALA G 117 N ALA G 92
SHEET 7 G 8 ALA G 220 GLY G 225 1 O LEU G 221 N PHE G 121
SHEET 8 G 8 GLU G 248 VAL G 252 1 O GLU G 248 N ILE G 222
SHEET 1 H 8 PHE H 2 THR H 4 0
SHEET 2 H 8 ASP H 14 HIS H 20 -1 O LEU H 15 N ILE H 3
SHEET 3 H 8 ARG H 52 TYR H 56 -1 O THR H 55 N GLU H 18
SHEET 4 H 8 PRO H 25 ILE H 29 1 N VAL H 26 O ARG H 52
SHEET 5 H 8 ALA H 92 PHE H 97 1 O VAL H 95 N VAL H 27
SHEET 6 H 8 ILE H 116 LEU H 122 1 O ALA H 117 N ALA H 92
SHEET 7 H 8 LEU H 221 GLY H 225 1 O LEU H 221 N PHE H 121
SHEET 8 H 8 GLU H 248 VAL H 252 1 O VAL H 250 N ILE H 222
SHEET 1 I 8 PHE I 2 THR I 4 0
SHEET 2 I 8 ASP I 14 HIS I 20 -1 O LEU I 15 N ILE I 3
SHEET 3 I 8 ARG I 52 TYR I 56 -1 O THR I 55 N GLU I 18
SHEET 4 I 8 PRO I 25 ILE I 29 1 N VAL I 26 O ARG I 52
SHEET 5 I 8 ALA I 92 PHE I 97 1 O VAL I 95 N VAL I 27
SHEET 6 I 8 ILE I 116 LEU I 122 1 O ALA I 117 N ALA I 92
SHEET 7 I 8 ALA I 220 GLY I 225 1 O LEU I 221 N PHE I 121
SHEET 8 I 8 GLU I 248 VAL I 252 1 O VAL I 250 N ILE I 222
SHEET 1 J 8 PHE J 2 THR J 4 0
SHEET 2 J 8 ASP J 14 HIS J 20 -1 O LEU J 15 N ILE J 3
SHEET 3 J 8 ARG J 52 TYR J 56 -1 O THR J 55 N GLU J 18
SHEET 4 J 8 PRO J 25 ILE J 29 1 N VAL J 26 O ARG J 52
SHEET 5 J 8 ALA J 92 PHE J 97 1 O VAL J 95 N ILE J 29
SHEET 6 J 8 ILE J 116 LEU J 122 1 O ALA J 117 N ALA J 92
SHEET 7 J 8 ALA J 220 GLY J 225 1 O LEU J 221 N PHE J 121
SHEET 8 J 8 GLU J 248 VAL J 252 1 O GLU J 248 N ALA J 220
SHEET 1 K 8 PHE K 2 THR K 4 0
SHEET 2 K 8 ASP K 14 HIS K 20 -1 O LEU K 15 N ILE K 3
SHEET 3 K 8 ARG K 52 TYR K 56 -1 O THR K 55 N GLU K 18
SHEET 4 K 8 PRO K 25 ILE K 29 1 N VAL K 26 O ARG K 52
SHEET 5 K 8 ALA K 92 PHE K 97 1 O VAL K 95 N VAL K 27
SHEET 6 K 8 ILE K 116 LEU K 122 1 O ALA K 117 N ALA K 92
SHEET 7 K 8 ALA K 220 GLY K 225 1 O LEU K 221 N PHE K 121
SHEET 8 K 8 GLU K 248 VAL K 252 1 O VAL K 250 N ILE K 222
SHEET 1 L 8 PHE L 2 THR L 4 0
SHEET 2 L 8 ASP L 14 HIS L 20 -1 O LEU L 15 N ILE L 3
SHEET 3 L 8 ARG L 52 TYR L 56 -1 O VAL L 53 N HIS L 20
SHEET 4 L 8 PRO L 25 ILE L 29 1 N VAL L 26 O ARG L 52
SHEET 5 L 8 ALA L 92 PHE L 97 1 O VAL L 95 N VAL L 27
SHEET 6 L 8 ILE L 116 LEU L 122 1 O ALA L 117 N ALA L 92
SHEET 7 L 8 ALA L 220 GLY L 225 1 O LEU L 221 N PHE L 121
SHEET 8 L 8 GLU L 248 VAL L 252 1 O VAL L 250 N ILE L 222
CISPEP 1 PHE A 32 PRO A 33 0 -6.40
CISPEP 2 GLU A 126 PRO A 127 0 -1.73
CISPEP 3 PHE B 32 PRO B 33 0 -6.09
CISPEP 4 GLU B 126 PRO B 127 0 -1.50
CISPEP 5 MET B 418 GLY B 419 0 -3.84
CISPEP 6 GLY B 419 ALA B 420 0 -4.08
CISPEP 7 ALA B 420 VAL B 421 0 2.72
CISPEP 8 PHE C 32 PRO C 33 0 -6.35
CISPEP 9 GLU C 126 PRO C 127 0 -1.21
CISPEP 10 PHE D 32 PRO D 33 0 -6.47
CISPEP 11 GLU D 126 PRO D 127 0 -1.56
CISPEP 12 PHE E 32 PRO E 33 0 -6.30
CISPEP 13 GLU E 126 PRO E 127 0 -1.51
CISPEP 14 MET E 418 GLY E 419 0 -3.30
CISPEP 15 GLY E 419 ALA E 420 0 -4.22
CISPEP 16 ALA E 420 VAL E 421 0 3.13
CISPEP 17 PHE F 32 PRO F 33 0 -6.03
CISPEP 18 GLU F 126 PRO F 127 0 -1.46
CISPEP 19 PHE G 32 PRO G 33 0 -6.59
CISPEP 20 GLU G 126 PRO G 127 0 -1.66
CISPEP 21 PHE H 32 PRO H 33 0 -6.20
CISPEP 22 GLU H 126 PRO H 127 0 -1.34
CISPEP 23 MET H 418 GLY H 419 0 -2.65
CISPEP 24 GLY H 419 ALA H 420 0 -3.41
CISPEP 25 ALA H 420 VAL H 421 0 3.15
CISPEP 26 PHE I 32 PRO I 33 0 -6.16
CISPEP 27 GLU I 126 PRO I 127 0 -1.36
CISPEP 28 PHE J 32 PRO J 33 0 -5.88
CISPEP 29 GLU J 126 PRO J 127 0 -1.76
CISPEP 30 MET J 418 GLY J 419 0 -3.51
CISPEP 31 GLY J 419 ALA J 420 0 -4.23
CISPEP 32 ALA J 420 VAL J 421 0 3.00
CISPEP 33 PHE K 32 PRO K 33 0 -6.41
CISPEP 34 GLU K 126 PRO K 127 0 -0.97
CISPEP 35 PHE L 32 PRO L 33 0 -6.28
CISPEP 36 GLU L 126 PRO L 127 0 -1.43
CRYST1 122.700 187.410 283.390 90.00 90.00 90.00 P 2 2 21 48
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 0.008150 0.000000 0.000000 0.00000
SCALE2 0.000000 0.005336 0.000000 0.00000
SCALE3 0.000000 0.000000 0.003529 0.00000
TER 3384 ALA A 438
TER 6768 ALA B 438
TER 10152 ALA C 438
TER 13536 ALA D 438
TER 16920 ALA E 438
TER 20304 ALA F 438
TER 23688 ALA G 438
TER 27072 ALA H 438
TER 30456 ALA I 438
TER 33840 ALA J 438
TER 37224 ALA K 438
TER 40608 ALA L 438
MASTER 516 0 0 265 96 0 0 640596 12 0 432
END |