longtext: 4DNF-pdb

content
HEADER    HYDROLASE                               08-FEB-12   4DNF
TITLE     CRYSTAL STRUCTURE OF THE CFTR INHIBITORY FACTOR CIF WITH THE E153Q
TITLE    2 MUTATION ADDUCTED WITH THE EPIBROMOHYDRIN HYDROLYSIS INTERMEDIATE
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: PUTATIVE HYDROLASE;
COMPND   3 CHAIN: A, B, C, D;
COMPND   4 FRAGMENT: CIF (UNP RESIDUES 25-319);
COMPND   5 ENGINEERED: YES;
COMPND   6 MUTATION: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: PSEUDOMONAS AERUGINOSA;
SOURCE   3 ORGANISM_TAXID: 208963;
SOURCE   4 STRAIN: UCBPP-PA14;
SOURCE   5 GENE: PA14_26090;
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: TOP10;
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PMQ70
KEYWDS    ALPHA BETA HYDROLASE, EPOXIDE HYDROLASE, COVALENTLY ADDUCTED WITH THE
KEYWDS   2 EPIBROMOHYDRIN HYDROLYSIS INTERMEDIATE, SECRETED, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    C.D.BAHL,D.R.MADDEN
REVDAT   1   07-AUG-13 4DNF    0
JRNL        AUTH   C.D.BAHL,D.R.MADDEN
JRNL        TITL   CIF EPOXIDE HYDROLASE ENZYME ACTIVITY IS REQUIRED FOR CFTR
JRNL        TITL 2 INHIBITORY ACTIVITY
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    1.80 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX (PHENIX.REFINE: 1.5_2)
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VICENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-
REMARK   3               : KUNSTLEVE,LI-WEI HUNG,ROBERT IMMORMINO,
REMARK   3               : TOM IOERGER,AIRLIE MCCOY,ERIK MCKEE,NIGEL
REMARK   3               : MORIARTY,REETAL PAI,RANDY READ,JANE
REMARK   3               : RICHARDSON,DAVID RICHARDSON,TOD ROMO,JIM
REMARK   3               : SACCHETTINI,NICHOLAS SAUTER,JACOB SMITH,
REMARK   3               : LAURENT STORONI,TOM TERWILLIGER,PETER
REMARK   3               : ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : MLHL
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.80
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 38.54
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.990
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.4
REMARK   3   NUMBER OF REFLECTIONS             : 112809
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.191
REMARK   3   R VALUE            (WORKING SET) : 0.189
REMARK   3   FREE R VALUE                     : 0.224
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.140
REMARK   3   FREE R VALUE TEST SET COUNT      : 5797
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 38.5497 -  5.5875    0.98     3589   237  0.2069 0.2114
REMARK   3     2  5.5875 -  4.4371    0.99     3589   220  0.1649 0.1762
REMARK   3     3  4.4371 -  3.8768    0.99     3639   143  0.1690 0.1741
REMARK   3     4  3.8768 -  3.5226    0.99     3579   185  0.1756 0.1978
REMARK   3     5  3.5226 -  3.2703    0.99     3581   222  0.1831 0.2028
REMARK   3     6  3.2703 -  3.0775    0.99     3507   248  0.1984 0.2441
REMARK   3     7  3.0775 -  2.9235    0.99     3444   312  0.2015 0.2281
REMARK   3     8  2.9235 -  2.7963    0.99     3732     0  0.1924 10000000.0000
REMARK   3     9  2.7963 -  2.6886    0.99     3442   335  0.1877 0.2330
REMARK   3    10  2.6886 -  2.5959    0.99     3772     0  0.1876 10000000.0000
REMARK   3    11  2.5959 -  2.5147    0.99     3366   395  0.1826 0.2255
REMARK   3    12  2.5147 -  2.4429    0.99     3759     0  0.1847 10000000.0000
REMARK   3    13  2.4429 -  2.3786    0.99     3287   446  0.1849 0.2327
REMARK   3    14  2.3786 -  2.3205    0.99     3772     0  0.1858 10000000.0000
REMARK   3    15  2.3205 -  2.2678    0.99     3263   468  0.1783 0.2062
REMARK   3    16  2.2678 -  2.2195    0.99     3756     0  0.1673 10000000.0000
REMARK   3    17  2.2195 -  2.1751    1.00     3310   460  0.1791 0.2366
REMARK   3    18  2.1751 -  2.1341    1.00     3612   116  0.1808 0.2494
REMARK   3    19  2.1341 -  2.0960    1.00     3756     0  0.1859 10000000.0000
REMARK   3    20  2.0960 -  2.0605    1.00     3155   609  0.1749 0.2195
REMARK   3    21  2.0605 -  2.0272    0.99     3751     0  0.1749 10000000.0000
REMARK   3    22  2.0272 -  1.9960    1.00     3708     0  0.1771 10000000.0000
REMARK   3    23  1.9960 -  1.9667    1.00     3128   658  0.1863 0.2390
REMARK   3    24  1.9667 -  1.9390    1.00     3761     0  0.1856 10000000.0000
REMARK   3    25  1.9390 -  1.9128    1.00     3720     0  0.1866 10000000.0000
REMARK   3    26  1.9128 -  1.8879    1.00     3715     0  0.1956 10000000.0000
REMARK   3    27  1.8879 -  1.8643    1.00     3037   742  0.1911 0.2561
REMARK   3    28  1.8643 -  1.8419    1.00     3756     0  0.1932 10000000.0000
REMARK   3    29  1.8419 -  1.8205    1.00     3785     0  0.1999 10000000.0000
REMARK   3    30  1.8205 -  1.8000    1.00     3741     1  0.2071 0.0000
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : 0.40
REMARK   3   B_SOL              : 39.97
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.220
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 21.600
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -2.81190
REMARK   3    B22 (A**2) : -2.89790
REMARK   3    B33 (A**2) : 3.62990
REMARK   3    B12 (A**2) : -0.00000
REMARK   3    B13 (A**2) : 0.14930
REMARK   3    B23 (A**2) : -0.00000
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.006           9833
REMARK   3   ANGLE     :  1.012          13349
REMARK   3   CHIRALITY :  0.074           1374
REMARK   3   PLANARITY :  0.005           1754
REMARK   3   DIHEDRAL  : 16.606           3545
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 4
REMARK   3   TLS GROUP : 1
REMARK   3    SELECTION: (chain A and resid 25:320)
REMARK   3    ORIGIN FOR THE GROUP (A): -21.9675  11.9494  27.2513
REMARK   3    T TENSOR
REMARK   3      T11:   0.0036 T22:   0.0060
REMARK   3      T33:  -0.0872 T12:   0.0035
REMARK   3      T13:  -0.0256 T23:   0.0440
REMARK   3    L TENSOR
REMARK   3      L11:   0.3023 L22:   0.1899
REMARK   3      L33:   0.2584 L12:   0.0239
REMARK   3      L13:   0.1686 L23:  -0.0434
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0176 S12:  -0.0217 S13:  -0.1462
REMARK   3      S21:   0.0491 S22:  -0.0730 S23:   0.1627
REMARK   3      S31:   0.0854 S32:  -0.0391 S33:  -0.0533
REMARK   3   TLS GROUP : 2
REMARK   3    SELECTION: (chain B and resid 25:320)
REMARK   3    ORIGIN FOR THE GROUP (A): -30.8609  51.5598  15.7372
REMARK   3    T TENSOR
REMARK   3      T11:   0.0229 T22:   0.0167
REMARK   3      T33:   0.0345 T12:   0.0215
REMARK   3      T13:  -0.0168 T23:  -0.0003
REMARK   3    L TENSOR
REMARK   3      L11:   0.3965 L22:   0.3956
REMARK   3      L33:   0.1659 L12:  -0.2745
REMARK   3      L13:   0.0162 L23:  -0.1684
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0114 S12:   0.0234 S13:   0.0707
REMARK   3      S21:  -0.0477 S22:   0.0117 S23:   0.0584
REMARK   3      S31:  -0.0395 S32:  -0.0133 S33:   0.0272
REMARK   3   TLS GROUP : 3
REMARK   3    SELECTION: (chain C and resid 25:320)
REMARK   3    ORIGIN FOR THE GROUP (A):   5.8775  44.6913  27.2357
REMARK   3    T TENSOR
REMARK   3      T11:   0.0060 T22:   0.0025
REMARK   3      T33:  -0.0142 T12:   0.0014
REMARK   3      T13:   0.0050 T23:  -0.0199
REMARK   3    L TENSOR
REMARK   3      L11:   0.3429 L22:   0.2740
REMARK   3      L33:   0.2941 L12:   0.0743
REMARK   3      L13:  -0.0833 L23:   0.0480
REMARK   3    S TENSOR
REMARK   3      S11:   0.0099 S12:  -0.0164 S13:   0.1381
REMARK   3      S21:   0.0053 S22:  -0.0413 S23:  -0.1040
REMARK   3      S31:  -0.0497 S32:   0.0502 S33:  -0.0377
REMARK   3   TLS GROUP : 4
REMARK   3    SELECTION: (chain D and resid 25:320)
REMARK   3    ORIGIN FOR THE GROUP (A):  14.7976   5.0678  15.7568
REMARK   3    T TENSOR
REMARK   3      T11:   0.0273 T22:   0.0294
REMARK   3      T33:  -0.0033 T12:   0.0184
REMARK   3      T13:   0.0115 T23:  -0.0041
REMARK   3    L TENSOR
REMARK   3      L11:   0.3125 L22:   0.3494
REMARK   3      L33:   0.1182 L12:  -0.2177
REMARK   3      L13:  -0.0051 L23:   0.1359
REMARK   3    S TENSOR
REMARK   3      S11:   0.0020 S12:   0.0235 S13:  -0.0135
REMARK   3      S21:  -0.0249 S22:   0.0034 S23:  -0.0703
REMARK   3      S31:   0.0151 S32:   0.0052 S33:  -0.0094
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 4DNF COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 10-FEB-12.
REMARK 100 THE RCSB ID CODE IS RCSB070546.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 20-OCT-08
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : NSLS
REMARK 200  BEAMLINE                       : X6A
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.8984
REMARK 200  MONOCHROMATOR                  : SI 111 CHANNEL
REMARK 200  OPTICS                         : TOROIDAL FOCUSING MIRROR
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 210
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS-PACKAGE
REMARK 200  DATA SCALING SOFTWARE          : XDS-PACKAGE
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 112816
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.800
REMARK 200  RESOLUTION RANGE LOW       (A) : 46.140
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.4
REMARK 200  DATA REDUNDANCY                : 4.100
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : 0.09000
REMARK 200   FOR THE DATA SET  : 11.8700
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.80
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.97
REMARK 200  COMPLETENESS FOR SHELL     (%) : 99.6
REMARK 200  DATA REDUNDANCY IN SHELL       : 4.20
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : 0.27800
REMARK 200   FOR SHELL         : 4.770
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHENIX
REMARK 200 STARTING MODEL: CHAIN A OF PDB ENTRY 3KD2
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 45.94
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.28
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 14% PEG 8000, 0.125M CALCIUM CHLORIDE,
REMARK 280  0.1M SODIUM ACETATE, 0.01M EPIBROMOHYDRIN, VAPOR DIFFUSION,
REMARK 280  HANGING DROP, TEMPERATURE 291K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 1 2 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y,-Z
REMARK 290       3555   X+1/2,Y+1/2,Z
REMARK 290       4555   -X+1/2,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   3  1.000000  0.000000  0.000000       84.07350
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       41.97950
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000       84.07350
REMARK 290   SMTRY2   4  0.000000  1.000000  0.000000       41.97950
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 2770 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 20730 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -21.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 2730 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 20870 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -22.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     HIS A   321
REMARK 465     HIS A   322
REMARK 465     HIS A   323
REMARK 465     HIS A   324
REMARK 465     HIS A   325
REMARK 465     HIS B   321
REMARK 465     HIS B   322
REMARK 465     HIS B   323
REMARK 465     HIS B   324
REMARK 465     HIS B   325
REMARK 465     HIS C   321
REMARK 465     HIS C   322
REMARK 465     HIS C   323
REMARK 465     HIS C   324
REMARK 465     HIS C   325
REMARK 465     HIS D   321
REMARK 465     HIS D   322
REMARK 465     HIS D   323
REMARK 465     HIS D   324
REMARK 465     HIS D   325
REMARK 480
REMARK 480 ZERO OCCUPANCY ATOM
REMARK 480 THE FOLLOWING RESIDUES HAVE ATOMS MODELED WITH ZERO
REMARK 480 OCCUPANCY. THE LOCATION AND PROPERTIES OF THESE ATOMS
REMARK 480 MAY NOT BE RELIABLE. (M=MODEL NUMBER; RES=RESIDUE NAME;
REMARK 480 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 480   M RES C SSEQI ATOMS
REMARK 480     ARG A  319   CB   CG   CD   NE   CZ   NH1  NH2
REMARK 480     ARG B  319   CB   CG   CD   NE   CZ   NH1  NH2
REMARK 480     ARG C  319   CB   CG   CD   NE   CZ   NH1  NH2
REMARK 480     ARG D  319   CB   CG   CD   NE   CZ   NH1  NH2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ASP A 129     -133.56     61.92
REMARK 500    ASN A 142       51.48   -140.50
REMARK 500    ALA A 154      147.81   -179.80
REMARK 500    CYS A 303       54.21   -144.58
REMARK 500    THR B  99      -67.01    -96.49
REMARK 500    ASP B 129     -132.14     61.09
REMARK 500    ALA B 154      147.54    179.98
REMARK 500    CYS B 303       55.92   -141.84
REMARK 500    THR C  99      -70.26    -84.77
REMARK 500    ASP C 129     -132.39     62.11
REMARK 500    ALA C 154      146.79    179.44
REMARK 500    ASP C 184      176.75    -59.14
REMARK 500    CYS C 303       57.32   -141.83
REMARK 500    THR D  99      -68.52    -95.14
REMARK 500    ASP D 129     -129.19     58.78
REMARK 500    ALA D 154      141.50    172.96
REMARK 500    CYS D 303       56.37   -142.70
REMARK 500
REMARK 500 REMARK: NULL
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE EBH A 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE EBH B 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE EBH C 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE EBH D 401
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 3KD2   RELATED DB: PDB
REMARK 900 SAME PROTEIN, BUT WITH THE WILD TYPE SEQUENCE
REMARK 900 RELATED ID: 3KDA   RELATED DB: PDB
REMARK 900 RELATED ID: 3PI6   RELATED DB: PDB
REMARK 900 RELATED ID: 4DLN   RELATED DB: PDB
REMARK 900 RELATED ID: 4DM7   RELATED DB: PDB
REMARK 900 RELATED ID: 4DMC   RELATED DB: PDB
REMARK 900 RELATED ID: 4DMF   RELATED DB: PDB
REMARK 900 RELATED ID: 4DMH   RELATED DB: PDB
REMARK 900 RELATED ID: 4DMK   RELATED DB: PDB
REMARK 900 RELATED ID: 4DNO   RELATED DB: PDB
DBREF  4DNF A   25   319  UNP    Q02P97   Q02P97_PSEAB    25    319
DBREF  4DNF B   25   319  UNP    Q02P97   Q02P97_PSEAB    25    319
DBREF  4DNF C   25   319  UNP    Q02P97   Q02P97_PSEAB    25    319
DBREF  4DNF D   25   319  UNP    Q02P97   Q02P97_PSEAB    25    319
SEQADV 4DNF GLN A  153  UNP  Q02P97    GLU   153 ENGINEERED MUTATION
SEQADV 4DNF HIS A  320  UNP  Q02P97              EXPRESSION TAG
SEQADV 4DNF HIS A  321  UNP  Q02P97              EXPRESSION TAG
SEQADV 4DNF HIS A  322  UNP  Q02P97              EXPRESSION TAG
SEQADV 4DNF HIS A  323  UNP  Q02P97              EXPRESSION TAG
SEQADV 4DNF HIS A  324  UNP  Q02P97              EXPRESSION TAG
SEQADV 4DNF HIS A  325  UNP  Q02P97              EXPRESSION TAG
SEQADV 4DNF GLN B  153  UNP  Q02P97    GLU   153 ENGINEERED MUTATION
SEQADV 4DNF HIS B  320  UNP  Q02P97              EXPRESSION TAG
SEQADV 4DNF HIS B  321  UNP  Q02P97              EXPRESSION TAG
SEQADV 4DNF HIS B  322  UNP  Q02P97              EXPRESSION TAG
SEQADV 4DNF HIS B  323  UNP  Q02P97              EXPRESSION TAG
SEQADV 4DNF HIS B  324  UNP  Q02P97              EXPRESSION TAG
SEQADV 4DNF HIS B  325  UNP  Q02P97              EXPRESSION TAG
SEQADV 4DNF GLN C  153  UNP  Q02P97    GLU   153 ENGINEERED MUTATION
SEQADV 4DNF HIS C  320  UNP  Q02P97              EXPRESSION TAG
SEQADV 4DNF HIS C  321  UNP  Q02P97              EXPRESSION TAG
SEQADV 4DNF HIS C  322  UNP  Q02P97              EXPRESSION TAG
SEQADV 4DNF HIS C  323  UNP  Q02P97              EXPRESSION TAG
SEQADV 4DNF HIS C  324  UNP  Q02P97              EXPRESSION TAG
SEQADV 4DNF HIS C  325  UNP  Q02P97              EXPRESSION TAG
SEQADV 4DNF GLN D  153  UNP  Q02P97    GLU   153 ENGINEERED MUTATION
SEQADV 4DNF HIS D  320  UNP  Q02P97              EXPRESSION TAG
SEQADV 4DNF HIS D  321  UNP  Q02P97              EXPRESSION TAG
SEQADV 4DNF HIS D  322  UNP  Q02P97              EXPRESSION TAG
SEQADV 4DNF HIS D  323  UNP  Q02P97              EXPRESSION TAG
SEQADV 4DNF HIS D  324  UNP  Q02P97              EXPRESSION TAG
SEQADV 4DNF HIS D  325  UNP  Q02P97              EXPRESSION TAG
SEQRES   1 A  301  ALA GLU GLU PHE PRO VAL PRO ASN GLY PHE GLU SER ALA
SEQRES   2 A  301  TYR ARG GLU VAL ASP GLY VAL LYS LEU HIS TYR VAL LYS
SEQRES   3 A  301  GLY GLY GLN GLY PRO LEU VAL MET LEU VAL HIS GLY PHE
SEQRES   4 A  301  GLY GLN THR TRP TYR GLU TRP HIS GLN LEU MET PRO GLU
SEQRES   5 A  301  LEU ALA LYS ARG PHE THR VAL ILE ALA PRO ASP LEU PRO
SEQRES   6 A  301  GLY LEU GLY GLN SER GLU PRO PRO LYS THR GLY TYR SER
SEQRES   7 A  301  GLY GLU GLN VAL ALA VAL TYR LEU HIS LYS LEU ALA ARG
SEQRES   8 A  301  GLN PHE SER PRO ASP ARG PRO PHE ASP LEU VAL ALA HIS
SEQRES   9 A  301  ASP ILE GLY ILE TRP ASN THR TYR PRO MET VAL VAL LYS
SEQRES  10 A  301  ASN GLN ALA ASP ILE ALA ARG LEU VAL TYR MET GLN ALA
SEQRES  11 A  301  PRO ILE PRO ASP ALA ARG ILE TYR ARG PHE PRO ALA PHE
SEQRES  12 A  301  THR ALA GLN GLY GLU SER LEU VAL TRP HIS PHE SER PHE
SEQRES  13 A  301  PHE ALA ALA ASP ASP ARG LEU ALA GLU THR LEU ILE ALA
SEQRES  14 A  301  GLY LYS GLU ARG PHE PHE LEU GLU HIS PHE ILE LYS SER
SEQRES  15 A  301  HIS ALA SER ASN THR GLU VAL PHE SER GLU ARG LEU LEU
SEQRES  16 A  301  ASP LEU TYR ALA ARG SER TYR ALA LYS PRO HIS SER LEU
SEQRES  17 A  301  ASN ALA SER PHE GLU TYR TYR ARG ALA LEU ASN GLU SER
SEQRES  18 A  301  VAL ARG GLN ASN ALA GLU LEU ALA LYS THR ARG LEU GLN
SEQRES  19 A  301  MET PRO THR MET THR LEU ALA GLY GLY GLY HIS GLY GLY
SEQRES  20 A  301  MET GLY THR PHE GLN LEU GLU GLN MET LYS ALA TYR ALA
SEQRES  21 A  301  GLU ASP VAL GLU GLY HIS VAL LEU PRO GLY CYS GLY HIS
SEQRES  22 A  301  TRP LEU PRO GLU GLU CYS ALA ALA PRO MET ASN ARG LEU
SEQRES  23 A  301  VAL ILE ASP PHE LEU SER ARG GLY ARG HIS HIS HIS HIS
SEQRES  24 A  301  HIS HIS
SEQRES   1 B  301  ALA GLU GLU PHE PRO VAL PRO ASN GLY PHE GLU SER ALA
SEQRES   2 B  301  TYR ARG GLU VAL ASP GLY VAL LYS LEU HIS TYR VAL LYS
SEQRES   3 B  301  GLY GLY GLN GLY PRO LEU VAL MET LEU VAL HIS GLY PHE
SEQRES   4 B  301  GLY GLN THR TRP TYR GLU TRP HIS GLN LEU MET PRO GLU
SEQRES   5 B  301  LEU ALA LYS ARG PHE THR VAL ILE ALA PRO ASP LEU PRO
SEQRES   6 B  301  GLY LEU GLY GLN SER GLU PRO PRO LYS THR GLY TYR SER
SEQRES   7 B  301  GLY GLU GLN VAL ALA VAL TYR LEU HIS LYS LEU ALA ARG
SEQRES   8 B  301  GLN PHE SER PRO ASP ARG PRO PHE ASP LEU VAL ALA HIS
SEQRES   9 B  301  ASP ILE GLY ILE TRP ASN THR TYR PRO MET VAL VAL LYS
SEQRES  10 B  301  ASN GLN ALA ASP ILE ALA ARG LEU VAL TYR MET GLN ALA
SEQRES  11 B  301  PRO ILE PRO ASP ALA ARG ILE TYR ARG PHE PRO ALA PHE
SEQRES  12 B  301  THR ALA GLN GLY GLU SER LEU VAL TRP HIS PHE SER PHE
SEQRES  13 B  301  PHE ALA ALA ASP ASP ARG LEU ALA GLU THR LEU ILE ALA
SEQRES  14 B  301  GLY LYS GLU ARG PHE PHE LEU GLU HIS PHE ILE LYS SER
SEQRES  15 B  301  HIS ALA SER ASN THR GLU VAL PHE SER GLU ARG LEU LEU
SEQRES  16 B  301  ASP LEU TYR ALA ARG SER TYR ALA LYS PRO HIS SER LEU
SEQRES  17 B  301  ASN ALA SER PHE GLU TYR TYR ARG ALA LEU ASN GLU SER
SEQRES  18 B  301  VAL ARG GLN ASN ALA GLU LEU ALA LYS THR ARG LEU GLN
SEQRES  19 B  301  MET PRO THR MET THR LEU ALA GLY GLY GLY HIS GLY GLY
SEQRES  20 B  301  MET GLY THR PHE GLN LEU GLU GLN MET LYS ALA TYR ALA
SEQRES  21 B  301  GLU ASP VAL GLU GLY HIS VAL LEU PRO GLY CYS GLY HIS
SEQRES  22 B  301  TRP LEU PRO GLU GLU CYS ALA ALA PRO MET ASN ARG LEU
SEQRES  23 B  301  VAL ILE ASP PHE LEU SER ARG GLY ARG HIS HIS HIS HIS
SEQRES  24 B  301  HIS HIS
SEQRES   1 C  301  ALA GLU GLU PHE PRO VAL PRO ASN GLY PHE GLU SER ALA
SEQRES   2 C  301  TYR ARG GLU VAL ASP GLY VAL LYS LEU HIS TYR VAL LYS
SEQRES   3 C  301  GLY GLY GLN GLY PRO LEU VAL MET LEU VAL HIS GLY PHE
SEQRES   4 C  301  GLY GLN THR TRP TYR GLU TRP HIS GLN LEU MET PRO GLU
SEQRES   5 C  301  LEU ALA LYS ARG PHE THR VAL ILE ALA PRO ASP LEU PRO
SEQRES   6 C  301  GLY LEU GLY GLN SER GLU PRO PRO LYS THR GLY TYR SER
SEQRES   7 C  301  GLY GLU GLN VAL ALA VAL TYR LEU HIS LYS LEU ALA ARG
SEQRES   8 C  301  GLN PHE SER PRO ASP ARG PRO PHE ASP LEU VAL ALA HIS
SEQRES   9 C  301  ASP ILE GLY ILE TRP ASN THR TYR PRO MET VAL VAL LYS
SEQRES  10 C  301  ASN GLN ALA ASP ILE ALA ARG LEU VAL TYR MET GLN ALA
SEQRES  11 C  301  PRO ILE PRO ASP ALA ARG ILE TYR ARG PHE PRO ALA PHE
SEQRES  12 C  301  THR ALA GLN GLY GLU SER LEU VAL TRP HIS PHE SER PHE
SEQRES  13 C  301  PHE ALA ALA ASP ASP ARG LEU ALA GLU THR LEU ILE ALA
SEQRES  14 C  301  GLY LYS GLU ARG PHE PHE LEU GLU HIS PHE ILE LYS SER
SEQRES  15 C  301  HIS ALA SER ASN THR GLU VAL PHE SER GLU ARG LEU LEU
SEQRES  16 C  301  ASP LEU TYR ALA ARG SER TYR ALA LYS PRO HIS SER LEU
SEQRES  17 C  301  ASN ALA SER PHE GLU TYR TYR ARG ALA LEU ASN GLU SER
SEQRES  18 C  301  VAL ARG GLN ASN ALA GLU LEU ALA LYS THR ARG LEU GLN
SEQRES  19 C  301  MET PRO THR MET THR LEU ALA GLY GLY GLY HIS GLY GLY
SEQRES  20 C  301  MET GLY THR PHE GLN LEU GLU GLN MET LYS ALA TYR ALA
SEQRES  21 C  301  GLU ASP VAL GLU GLY HIS VAL LEU PRO GLY CYS GLY HIS
SEQRES  22 C  301  TRP LEU PRO GLU GLU CYS ALA ALA PRO MET ASN ARG LEU
SEQRES  23 C  301  VAL ILE ASP PHE LEU SER ARG GLY ARG HIS HIS HIS HIS
SEQRES  24 C  301  HIS HIS
SEQRES   1 D  301  ALA GLU GLU PHE PRO VAL PRO ASN GLY PHE GLU SER ALA
SEQRES   2 D  301  TYR ARG GLU VAL ASP GLY VAL LYS LEU HIS TYR VAL LYS
SEQRES   3 D  301  GLY GLY GLN GLY PRO LEU VAL MET LEU VAL HIS GLY PHE
SEQRES   4 D  301  GLY GLN THR TRP TYR GLU TRP HIS GLN LEU MET PRO GLU
SEQRES   5 D  301  LEU ALA LYS ARG PHE THR VAL ILE ALA PRO ASP LEU PRO
SEQRES   6 D  301  GLY LEU GLY GLN SER GLU PRO PRO LYS THR GLY TYR SER
SEQRES   7 D  301  GLY GLU GLN VAL ALA VAL TYR LEU HIS LYS LEU ALA ARG
SEQRES   8 D  301  GLN PHE SER PRO ASP ARG PRO PHE ASP LEU VAL ALA HIS
SEQRES   9 D  301  ASP ILE GLY ILE TRP ASN THR TYR PRO MET VAL VAL LYS
SEQRES  10 D  301  ASN GLN ALA ASP ILE ALA ARG LEU VAL TYR MET GLN ALA
SEQRES  11 D  301  PRO ILE PRO ASP ALA ARG ILE TYR ARG PHE PRO ALA PHE
SEQRES  12 D  301  THR ALA GLN GLY GLU SER LEU VAL TRP HIS PHE SER PHE
SEQRES  13 D  301  PHE ALA ALA ASP ASP ARG LEU ALA GLU THR LEU ILE ALA
SEQRES  14 D  301  GLY LYS GLU ARG PHE PHE LEU GLU HIS PHE ILE LYS SER
SEQRES  15 D  301  HIS ALA SER ASN THR GLU VAL PHE SER GLU ARG LEU LEU
SEQRES  16 D  301  ASP LEU TYR ALA ARG SER TYR ALA LYS PRO HIS SER LEU
SEQRES  17 D  301  ASN ALA SER PHE GLU TYR TYR ARG ALA LEU ASN GLU SER
SEQRES  18 D  301  VAL ARG GLN ASN ALA GLU LEU ALA LYS THR ARG LEU GLN
SEQRES  19 D  301  MET PRO THR MET THR LEU ALA GLY GLY GLY HIS GLY GLY
SEQRES  20 D  301  MET GLY THR PHE GLN LEU GLU GLN MET LYS ALA TYR ALA
SEQRES  21 D  301  GLU ASP VAL GLU GLY HIS VAL LEU PRO GLY CYS GLY HIS
SEQRES  22 D  301  TRP LEU PRO GLU GLU CYS ALA ALA PRO MET ASN ARG LEU
SEQRES  23 D  301  VAL ILE ASP PHE LEU SER ARG GLY ARG HIS HIS HIS HIS
SEQRES  24 D  301  HIS HIS
HET    EBH  A 401       5
HET    EBH  B 401       5
HET    EBH  C 401       5
HET    EBH  D 401       5
HETNAM     EBH (2S)-1-BROMOPROPAN-2-OL
FORMUL   5  EBH    4(C3 H7 BR O)
FORMUL   9  HOH   *829(H2 O)
HELIX    1   1 THR A   66  HIS A   71  5                                   6
HELIX    2   2 LEU A   73  ALA A   78  1                                   6
HELIX    3   3 SER A  102  SER A  118  1                                  17
HELIX    4   4 ASP A  129  ASN A  134  1                                   6
HELIX    5   5 THR A  135  ASN A  142  1                                   8
HELIX    6   6 ASP A  158  PHE A  164  5                                   7
HELIX    7   7 VAL A  175  ALA A  183  1                                   9
HELIX    8   8 ARG A  186  ALA A  193  1                                   8
HELIX    9   9 LYS A  195  HIS A  207  1                                  13
HELIX   10  10 ASN A  210  PHE A  214  5                                   5
HELIX   11  11 SER A  215  ALA A  227  1                                  13
HELIX   12  12 LYS A  228  ALA A  241  1                                  14
HELIX   13  13 ALA A  241  ALA A  253  1                                  13
HELIX   14  14 THR A  274  ALA A  284  1                                  11
HELIX   15  15 TRP A  298  CYS A  303  1                                   6
HELIX   16  16 CYS A  303  SER A  316  1                                  14
HELIX   17  17 THR B   66  HIS B   71  5                                   6
HELIX   18  18 GLN B   72  ALA B   78  1                                   7
HELIX   19  19 SER B  102  SER B  118  1                                  17
HELIX   20  20 ASP B  129  ASN B  134  1                                   6
HELIX   21  21 THR B  135  ASN B  142  1                                   8
HELIX   22  22 ASP B  158  PHE B  164  5                                   7
HELIX   23  23 VAL B  175  ALA B  183  1                                   9
HELIX   24  24 ARG B  186  ALA B  193  1                                   8
HELIX   25  25 LYS B  195  HIS B  207  1                                  13
HELIX   26  26 ASN B  210  PHE B  214  5                                   5
HELIX   27  27 SER B  215  LYS B  228  1                                  14
HELIX   28  28 LYS B  228  ALA B  241  1                                  14
HELIX   29  29 ALA B  241  ALA B  253  1                                  13
HELIX   30  30 THR B  274  ALA B  284  1                                  11
HELIX   31  31 TRP B  298  CYS B  303  1                                   6
HELIX   32  32 CYS B  303  SER B  316  1                                  14
HELIX   33  33 THR C   66  HIS C   71  5                                   6
HELIX   34  34 LEU C   73  ALA C   78  1                                   6
HELIX   35  35 SER C  102  SER C  118  1                                  17
HELIX   36  36 ASP C  129  ASN C  134  1                                   6
HELIX   37  37 THR C  135  ASN C  142  1                                   8
HELIX   38  38 ASP C  158  PHE C  164  5                                   7
HELIX   39  39 VAL C  175  ALA C  183  1                                   9
HELIX   40  40 ARG C  186  ALA C  193  1                                   8
HELIX   41  41 LYS C  195  HIS C  207  1                                  13
HELIX   42  42 ASN C  210  PHE C  214  5                                   5
HELIX   43  43 SER C  215  ALA C  227  1                                  13
HELIX   44  44 LYS C  228  ALA C  241  1                                  14
HELIX   45  45 ALA C  241  ALA C  253  1                                  13
HELIX   46  46 THR C  274  LYS C  281  1                                   8
HELIX   47  47 TRP C  298  CYS C  303  1                                   6
HELIX   48  48 CYS C  303  SER C  316  1                                  14
HELIX   49  49 THR D   66  HIS D   71  5                                   6
HELIX   50  50 GLN D   72  ALA D   78  1                                   7
HELIX   51  51 SER D  102  SER D  118  1                                  17
HELIX   52  52 ASP D  129  ASN D  134  1                                   6
HELIX   53  53 THR D  135  ASN D  142  1                                   8
HELIX   54  54 ASP D  158  PHE D  164  5                                   7
HELIX   55  55 VAL D  175  ALA D  183  1                                   9
HELIX   56  56 ARG D  186  ALA D  193  1                                   8
HELIX   57  57 LYS D  195  HIS D  207  1                                  13
HELIX   58  58 ASN D  210  PHE D  214  5                                   5
HELIX   59  59 SER D  215  ALA D  227  1                                  13
HELIX   60  60 LYS D  228  ALA D  241  1                                  14
HELIX   61  61 ALA D  241  ALA D  253  1                                  13
HELIX   62  62 THR D  274  ALA D  282  1                                   9
HELIX   63  63 TRP D  298  CYS D  303  1                                   6
HELIX   64  64 CYS D  303  ARG D  317  1                                  15
SHEET    1   A 8 GLU A  35  VAL A  41  0
SHEET    2   A 8 VAL A  44  GLY A  52 -1  O  VAL A  44   N  VAL A  41
SHEET    3   A 8 THR A  82  PRO A  86 -1  O  VAL A  83   N  GLY A  51
SHEET    4   A 8 LEU A  56  VAL A  60  1  N  VAL A  57   O  THR A  82
SHEET    5   A 8 PHE A 123  HIS A 128  1  O  ASP A 124   N  MET A  58
SHEET    6   A 8 ILE A 146  MET A 152  1  O  VAL A 150   N  LEU A 125
SHEET    7   A 8 THR A 261  GLY A 266  1  O  MET A 262   N  LEU A 149
SHEET    8   A 8 VAL A 287  LEU A 292  1  O  LEU A 292   N  ALA A 265
SHEET    1   B 8 PHE B  34  VAL B  41  0
SHEET    2   B 8 VAL B  44  GLY B  52 -1  O  LYS B  50   N  GLU B  35
SHEET    3   B 8 THR B  82  PRO B  86 -1  O  VAL B  83   N  GLY B  51
SHEET    4   B 8 LEU B  56  VAL B  60  1  N  VAL B  57   O  ILE B  84
SHEET    5   B 8 PHE B 123  HIS B 128  1  O  VAL B 126   N  VAL B  60
SHEET    6   B 8 ILE B 146  MET B 152  1  O  VAL B 150   N  ALA B 127
SHEET    7   B 8 THR B 261  GLY B 266  1  O  MET B 262   N  LEU B 149
SHEET    8   B 8 VAL B 287  LEU B 292  1  O  LEU B 292   N  ALA B 265
SHEET    1   C 2 PHE B 167  THR B 168  0
SHEET    2   C 2 GLY B 171  GLU B 172 -1  O  GLY B 171   N  THR B 168
SHEET    1   D 8 GLU C  35  VAL C  41  0
SHEET    2   D 8 VAL C  44  GLY C  52 -1  O  VAL C  44   N  VAL C  41
SHEET    3   D 8 THR C  82  PRO C  86 -1  O  VAL C  83   N  GLY C  51
SHEET    4   D 8 LEU C  56  VAL C  60  1  N  VAL C  57   O  THR C  82
SHEET    5   D 8 PHE C 123  HIS C 128  1  O  ASP C 124   N  MET C  58
SHEET    6   D 8 ILE C 146  MET C 152  1  O  VAL C 150   N  LEU C 125
SHEET    7   D 8 THR C 261  GLY C 266  1  O  MET C 262   N  TYR C 151
SHEET    8   D 8 VAL C 287  LEU C 292  1  O  LEU C 292   N  ALA C 265
SHEET    1   E 8 PHE D  34  VAL D  41  0
SHEET    2   E 8 VAL D  44  GLY D  52 -1  O  VAL D  44   N  VAL D  41
SHEET    3   E 8 THR D  82  PRO D  86 -1  O  VAL D  83   N  GLY D  51
SHEET    4   E 8 LEU D  56  VAL D  60  1  N  VAL D  57   O  ILE D  84
SHEET    5   E 8 PHE D 123  HIS D 128  1  O  VAL D 126   N  VAL D  60
SHEET    6   E 8 ILE D 146  MET D 152  1  O  VAL D 150   N  LEU D 125
SHEET    7   E 8 THR D 261  GLY D 266  1  O  MET D 262   N  LEU D 149
SHEET    8   E 8 VAL D 287  LEU D 292  1  O  LEU D 292   N  ALA D 265
SHEET    1   F 2 PHE D 167  THR D 168  0
SHEET    2   F 2 GLY D 171  GLU D 172 -1  O  GLY D 171   N  THR D 168
SSBOND   1 CYS A  295    CYS A  303                          1555   1555  2.02
SSBOND   2 CYS B  295    CYS B  303                          1555   1555  2.00
SSBOND   3 CYS C  295    CYS C  303                          1555   1555  2.01
SSBOND   4 CYS D  295    CYS D  303                          1555   1555  2.01
LINK         OD2 ASP A 129                 C02 EBH A 401     1555   1555  1.38
LINK         OD2 ASP B 129                 C02 EBH B 401     1555   1555  1.38
LINK         OD2 ASP C 129                 C02 EBH C 401     1555   1555  1.38
LINK         OD2 ASP D 129                 C02 EBH D 401     1555   1555  1.38
SITE     1 AC1  5 ASP A 129  HIS A 177  PHE A 178  TYR A 239
SITE     2 AC1  5 HIS A 297
SITE     1 AC2  6 ASP B 129  ALA B 154  HIS B 177  PHE B 178
SITE     2 AC2  6 TYR B 239  HIS B 297
SITE     1 AC3  5 ASP C 129  HIS C 177  PHE C 178  TYR C 239
SITE     2 AC3  5 HIS C 297
SITE     1 AC4  5 ASP D 129  HIS D 177  PHE D 178  TYR D 239
SITE     2 AC4  5 HIS D 297
CRYST1  168.147   83.959   89.536  90.00 100.31  90.00 C 1 2 1      16
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.005947  0.000000  0.001081        0.00000
SCALE2      0.000000  0.011911  0.000000        0.00000
SCALE3      0.000000  0.000000  0.011352        0.00000
TER    2396      HIS A 320
TER    4763      HIS B 320
TER    7141      HIS C 320
TER    9513      HIS D 320
MASTER      397    0    4   64   36    0    8    610301    4   32   96
END