longtext: 4DNP-pdb

content
HEADER    HYDROLASE                               08-FEB-12   4DNP
TITLE     CRYSTAL STRUCTURE OF DAD2
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: DAD2;
COMPND   3 CHAIN: A;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: PETUNIA HYBRIDA;
SOURCE   3 ORGANISM_TAXID: 4102;
SOURCE   4 GENE: DAD2;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE   7 EXPRESSION_SYSTEM_STRAIN: ROSETTA GAMI 2;
SOURCE   8 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE   9 EXPRESSION_SYSTEM_PLASMID: PDEST566
KEYWDS    ALPHA/BETA HYDROLASE, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    C.HAMIAUX
REVDAT   1   14-NOV-12 4DNP    0
JRNL        AUTH   C.HAMIAUX,R.S.DRUMMOND,B.J.JANSSEN,S.E.LEDGER,J.M.COONEY,
JRNL        AUTH 2 R.D.NEWCOMB,K.C.SNOWDEN
JRNL        TITL   DAD2 IS AN ALPHA/BETA HYDROLASE LIKELY TO BE INVOLVED IN THE
JRNL        TITL 2 PERCEPTION OF THE PLANT BRANCHING HORMONE, STRIGOLACTONE
JRNL        REF    CURR.BIOL.                                 2012
JRNL        REFN                   ISSN 0960-9822
JRNL        PMID   22959345
JRNL        DOI    10.1016/J.CUB.2012.08.007
REMARK   2
REMARK   2 RESOLUTION.    2.15 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.5.0109
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.15
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 40.88
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.9
REMARK   3   NUMBER OF REFLECTIONS             : 19671
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.169
REMARK   3   R VALUE            (WORKING SET) : 0.167
REMARK   3   FREE R VALUE                     : 0.211
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.100
REMARK   3   FREE R VALUE TEST SET COUNT      : 1006
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.15
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.21
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 1372
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 100.00
REMARK   3   BIN R VALUE           (WORKING SET) : 0.1750
REMARK   3   BIN FREE R VALUE SET COUNT          : 79
REMARK   3   BIN FREE R VALUE                    : 0.2150
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 2064
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 14
REMARK   3   SOLVENT ATOMS            : 182
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 23.60
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 26.59
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.178
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.161
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.100
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 8.332
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.952
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.928
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  2137 ; 0.016 ; 0.022
REMARK   3   BOND LENGTHS OTHERS               (A):  1440 ; 0.001 ; 0.020
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES):  2904 ; 1.491 ; 1.955
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  3474 ; 0.961 ; 3.001
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):   264 ; 5.921 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   100 ;30.147 ;22.500
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):   332 ;15.762 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    19 ;20.005 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):   328 ; 0.107 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  2390 ; 0.006 ; 0.021
REMARK   3   GENERAL PLANES OTHERS             (A):   474 ; 0.001 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  1310 ; 0.766 ; 1.500
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):   533 ; 0.207 ; 1.500
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  2111 ; 1.471 ; 2.000
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):   827 ; 2.500 ; 3.000
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):   792 ; 4.050 ; 4.500
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 1
REMARK   3
REMARK   3   TLS GROUP : 1
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A     3        A   265
REMARK   3    ORIGIN FOR THE GROUP (A): -44.5940 -43.4720   8.5130
REMARK   3    T TENSOR
REMARK   3      T11:   0.1078 T22:   0.0499
REMARK   3      T33:   0.0911 T12:   0.0304
REMARK   3      T13:  -0.0818 T23:   0.0010
REMARK   3    L TENSOR
REMARK   3      L11:   3.0324 L22:   1.4501
REMARK   3      L33:   1.2537 L12:  -0.3950
REMARK   3      L13:   0.2780 L23:  -0.1872
REMARK   3    S TENSOR
REMARK   3      S11:  -0.1530 S12:  -0.2391 S13:   0.1327
REMARK   3      S21:   0.0647 S22:   0.0455 S23:  -0.0938
REMARK   3      S31:  -0.1377 S32:   0.0210 S33:   0.1076
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.40
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING
REMARK   3  POSITIONS U VALUES : WITH TLS ADDED
REMARK   4
REMARK   4 4DNP COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 09-FEB-12.
REMARK 100 THE RCSB ID CODE IS RCSB070556.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 11-MAR-11
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 7.1
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : AUSTRALIAN SYNCHROTRON
REMARK 200  BEAMLINE                       : MX2
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.979417
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 210R
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : MOSFLM
REMARK 200  DATA SCALING SOFTWARE          : SCALA
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 19684
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.150
REMARK 200  RESOLUTION RANGE LOW       (A) : 40.876
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 0.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 100.0
REMARK 200  DATA REDUNDANCY                : 21.700
REMARK 200  R MERGE                    (I) : 0.12600
REMARK 200  R SYM                      (I) : 0.12600
REMARK 200   FOR THE DATA SET  : 20.1000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.15
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.27
REMARK 200  COMPLETENESS FOR SHELL     (%) : 100.0
REMARK 200  DATA REDUNDANCY IN SHELL       : 22.10
REMARK 200  R MERGE FOR SHELL          (I) : 0.45800
REMARK 200  R SYM FOR SHELL            (I) : 0.45800
REMARK 200   FOR SHELL         : 7.700
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 59.18
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.01
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: (NH4)2HPO4 0.6M, PH 7.1, VAPOR
REMARK 280  DIFFUSION, TEMPERATURE 291K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: I 2 3
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,-Y,Z
REMARK 290       3555   -X,Y,-Z
REMARK 290       4555   X,-Y,-Z
REMARK 290       5555   Z,X,Y
REMARK 290       6555   Z,-X,-Y
REMARK 290       7555   -Z,-X,Y
REMARK 290       8555   -Z,X,-Y
REMARK 290       9555   Y,Z,X
REMARK 290      10555   -Y,Z,-X
REMARK 290      11555   Y,-Z,-X
REMARK 290      12555   -Y,-Z,X
REMARK 290      13555   X+1/2,Y+1/2,Z+1/2
REMARK 290      14555   -X+1/2,-Y+1/2,Z+1/2
REMARK 290      15555   -X+1/2,Y+1/2,-Z+1/2
REMARK 290      16555   X+1/2,-Y+1/2,-Z+1/2
REMARK 290      17555   Z+1/2,X+1/2,Y+1/2
REMARK 290      18555   Z+1/2,-X+1/2,-Y+1/2
REMARK 290      19555   -Z+1/2,-X+1/2,Y+1/2
REMARK 290      20555   -Z+1/2,X+1/2,-Y+1/2
REMARK 290      21555   Y+1/2,Z+1/2,X+1/2
REMARK 290      22555   -Y+1/2,Z+1/2,-X+1/2
REMARK 290      23555   Y+1/2,-Z+1/2,-X+1/2
REMARK 290      24555   -Y+1/2,-Z+1/2,X+1/2
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   5  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY2   5  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   5  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY1   6  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY2   6 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   6  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY1   7  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY2   7 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   7  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY1   8  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY2   8  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   8  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY1   9  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY2   9  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY3   9  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY1  10  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY2  10  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY3  10 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY1  11  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY2  11  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY3  11 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY1  12  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY2  12  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY3  12  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY1  13  1.000000  0.000000  0.000000       64.63000
REMARK 290   SMTRY2  13  0.000000  1.000000  0.000000       64.63000
REMARK 290   SMTRY3  13  0.000000  0.000000  1.000000       64.63000
REMARK 290   SMTRY1  14 -1.000000  0.000000  0.000000       64.63000
REMARK 290   SMTRY2  14  0.000000 -1.000000  0.000000       64.63000
REMARK 290   SMTRY3  14  0.000000  0.000000  1.000000       64.63000
REMARK 290   SMTRY1  15 -1.000000  0.000000  0.000000       64.63000
REMARK 290   SMTRY2  15  0.000000  1.000000  0.000000       64.63000
REMARK 290   SMTRY3  15  0.000000  0.000000 -1.000000       64.63000
REMARK 290   SMTRY1  16  1.000000  0.000000  0.000000       64.63000
REMARK 290   SMTRY2  16  0.000000 -1.000000  0.000000       64.63000
REMARK 290   SMTRY3  16  0.000000  0.000000 -1.000000       64.63000
REMARK 290   SMTRY1  17  0.000000  0.000000  1.000000       64.63000
REMARK 290   SMTRY2  17  1.000000  0.000000  0.000000       64.63000
REMARK 290   SMTRY3  17  0.000000  1.000000  0.000000       64.63000
REMARK 290   SMTRY1  18  0.000000  0.000000  1.000000       64.63000
REMARK 290   SMTRY2  18 -1.000000  0.000000  0.000000       64.63000
REMARK 290   SMTRY3  18  0.000000 -1.000000  0.000000       64.63000
REMARK 290   SMTRY1  19  0.000000  0.000000 -1.000000       64.63000
REMARK 290   SMTRY2  19 -1.000000  0.000000  0.000000       64.63000
REMARK 290   SMTRY3  19  0.000000  1.000000  0.000000       64.63000
REMARK 290   SMTRY1  20  0.000000  0.000000 -1.000000       64.63000
REMARK 290   SMTRY2  20  1.000000  0.000000  0.000000       64.63000
REMARK 290   SMTRY3  20  0.000000 -1.000000  0.000000       64.63000
REMARK 290   SMTRY1  21  0.000000  1.000000  0.000000       64.63000
REMARK 290   SMTRY2  21  0.000000  0.000000  1.000000       64.63000
REMARK 290   SMTRY3  21  1.000000  0.000000  0.000000       64.63000
REMARK 290   SMTRY1  22  0.000000 -1.000000  0.000000       64.63000
REMARK 290   SMTRY2  22  0.000000  0.000000  1.000000       64.63000
REMARK 290   SMTRY3  22 -1.000000  0.000000  0.000000       64.63000
REMARK 290   SMTRY1  23  0.000000  1.000000  0.000000       64.63000
REMARK 290   SMTRY2  23  0.000000  0.000000 -1.000000       64.63000
REMARK 290   SMTRY3  23 -1.000000  0.000000  0.000000       64.63000
REMARK 290   SMTRY1  24  0.000000 -1.000000  0.000000       64.63000
REMARK 290   SMTRY2  24  0.000000  0.000000 -1.000000       64.63000
REMARK 290   SMTRY3  24  1.000000  0.000000  0.000000       64.63000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 300 REMARK: THIS PROTEIN BEHAVES AS A MONOMER ON GEL FILTRATION COLUMN
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 1760 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 22060 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -17.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350   BIOMT1   2  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   2  0.000000 -1.000000  0.000000     -129.26000
REMARK 350   BIOMT3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     GLY A    -1
REMARK 465     GLY A     0
REMARK 465     MET A     1
REMARK 465     GLY A     2
REMARK 465     HIS A   266
REMARK 465     ARG A   267
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   SG   CYS A    89     S1   DTV A   301              2.02
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS
REMARK 500
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.
REMARK 500
REMARK 500 DISTANCE CUTOFF:
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE
REMARK 500   SG   CYS A    89     S4   DTV A   301     4545     2.08
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    SER A  96     -133.39     63.28
REMARK 500    LYS A 115      140.16   -170.68
REMARK 500    ARG A 124      123.74   -174.73
REMARK 500    ASN A 150       86.88   -166.51
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH A 551        DISTANCE =  5.67 ANGSTROMS
REMARK 525    HOH A 562        DISTANCE =  6.10 ANGSTROMS
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE DTV A 301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL A 302
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 4DNQ   RELATED DB: PDB
DBREF  4DNP A   -1   267  PDB    4DNP     4DNP            -1    267
SEQRES   1 A  269  GLY GLY MET GLY GLN THR LEU LEU ASP ALA LEU ASN VAL
SEQRES   2 A  269  ARG VAL VAL GLY SER GLY GLU ARG VAL LEU VAL LEU ALA
SEQRES   3 A  269  HIS GLY PHE GLY THR ASP GLN SER ALA TRP ASN ARG ILE
SEQRES   4 A  269  LEU PRO PHE PHE LEU ARG ASP TYR ARG VAL VAL LEU TYR
SEQRES   5 A  269  ASP LEU VAL CYS ALA GLY SER VAL ASN PRO ASP PHE PHE
SEQRES   6 A  269  ASP PHE ARG ARG TYR THR THR LEU ASP PRO TYR VAL ASP
SEQRES   7 A  269  ASP LEU LEU HIS ILE LEU ASP ALA LEU GLY ILE ASP CYS
SEQRES   8 A  269  CYS ALA TYR VAL GLY HIS SER VAL SER ALA MET ILE GLY
SEQRES   9 A  269  ILE LEU ALA SER ILE ARG ARG PRO GLU LEU PHE SER LYS
SEQRES  10 A  269  LEU ILE LEU ILE GLY ALA SER PRO ARG PHE LEU ASN ASP
SEQRES  11 A  269  GLU ASP TYR HIS GLY GLY PHE GLU GLN GLY GLU ILE GLU
SEQRES  12 A  269  LYS VAL PHE SER ALA MET GLU ALA ASN TYR GLU ALA TRP
SEQRES  13 A  269  VAL ASN GLY PHE ALA PRO LEU ALA VAL GLY ALA ASP VAL
SEQRES  14 A  269  PRO ALA ALA VAL ARG GLU PHE SER ARG THR LEU PHE ASN
SEQRES  15 A  269  MET ARG PRO ASP ILE THR LEU PHE VAL SER ARG THR VAL
SEQRES  16 A  269  PHE ASN SER ASP MET ARG GLY VAL LEU GLY LEU VAL LYS
SEQRES  17 A  269  VAL PRO CYS HIS ILE PHE GLN THR ALA ARG ASP HIS SER
SEQRES  18 A  269  VAL PRO ALA SER VAL ALA THR TYR LEU LYS ASN HIS LEU
SEQRES  19 A  269  GLY GLY LYS ASN THR VAL HIS TRP LEU ASN ILE GLU GLY
SEQRES  20 A  269  HIS LEU PRO HIS LEU SER ALA PRO THR LEU LEU ALA GLN
SEQRES  21 A  269  GLU LEU ARG ARG ALA LEU SER HIS ARG
HET    DTV  A 301       8
HET    GOL  A 302       6
HETNAM     DTV (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL
HETNAM     GOL GLYCEROL
HETSYN     GOL GLYCERIN; PROPANE-1,2,3-TRIOL
FORMUL   2  DTV    C4 H10 O2 S2
FORMUL   3  GOL    C3 H8 O3
FORMUL   4  HOH   *182(H2 O)
HELIX    1   1 GLN A    3  LEU A    9  1                                   7
HELIX    2   2 ASP A   30  ASN A   35  5                                   6
HELIX    3   3 ILE A   37  LEU A   42  5                                   6
HELIX    4   4 ASN A   59  PHE A   63  5                                   5
HELIX    5   5 LEU A   71  LEU A   85  1                                  15
HELIX    6   6 SER A   96  ARG A  109  1                                  14
HELIX    7   7 GLU A  136  ASN A  150  1                                  15
HELIX    8   8 ASN A  150  GLY A  164  1                                  15
HELIX    9   9 VAL A  167  MET A  181  1                                  15
HELIX   10  10 ARG A  182  ASN A  195  1                                  14
HELIX   11  11 MET A  198  VAL A  205  5                                   8
HELIX   12  12 PRO A  221  LEU A  232  1                                  12
HELIX   13  13 LEU A  247  ALA A  252  1                                   6
HELIX   14  14 ALA A  252  SER A  265  1                                  14
SHEET    1   A 7 ARG A  12  VAL A  14  0
SHEET    2   A 7 ARG A  46  TYR A  50 -1  O  VAL A  47   N  VAL A  14
SHEET    3   A 7 VAL A  20  ALA A  24  1  N  LEU A  21   O  VAL A  48
SHEET    4   A 7 CYS A  90  HIS A  95  1  O  ALA A  91   N  VAL A  22
SHEET    5   A 7 PHE A 113  ILE A 119  1  O  ILE A 117   N  TYR A  92
SHEET    6   A 7 CYS A 209  ALA A 215  1  O  PHE A 212   N  LEU A 118
SHEET    7   A 7 ASN A 236  GLU A 244  1  O  THR A 237   N  ILE A 211
SITE     1 AC1  1 CYS A  89
SITE     1 AC2  6 SER A  96  VAL A  97  PHE A 125  HIS A 246
SITE     2 AC2  6 HOH A 580  HOH A 582
CRYST1  129.260  129.260  129.260  90.00  90.00  90.00 I 2 3        24
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.007736  0.000000  0.000000        0.00000
SCALE2      0.000000  0.007736  0.000000        0.00000
SCALE3      0.000000  0.000000  0.007736        0.00000
TER    2073      SER A 265
MASTER      430    0    2   14    7    0    3    6 2260    1   14   21
END