longtext: 4EB0-pdb

content
HEADER    HYDROLASE                               23-MAR-12   4EB0
TITLE     CRYSTAL STRUCTURE OF LEAF-BRANCH COMPOST BACTERIAL CUTINASE HOMOLOG
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: LCC;
COMPND   3 CHAIN: A;
COMPND   4 FRAGMENT: UNP RESIDUES 36-293;
COMPND   5 EC: 3.1.1.74;
COMPND   6 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: UNCULTURED BACTERIUM;
SOURCE   3 ORGANISM_TAXID: 77133;
SOURCE   4 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   5 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE   6 EXPRESSION_SYSTEM_STRAIN: BL21-CODONPLUS(DE3)-RP;
SOURCE   7 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE   8 EXPRESSION_SYSTEM_PLASMID: PET25B
KEYWDS    HYDROLASE, SERINE ESTERASE, CUTINASE HOMOLOG, PET DEGRADATION,
KEYWDS   2 METAGENOME
EXPDTA    X-RAY DIFFRACTION
AUTHOR    S.SULAIMAN,D.J.YOU,K.EIKO,Y.KOGA,S.KANAYA
REVDAT   1   27-MAR-13 4EB0    0
JRNL        AUTH   S.SULAIMAN,D.J.YOU,K.EIKO,Y.KOGA,S.KANAYA
JRNL        TITL   CRYSTAL STRUCTURE OF LEAF-BRANCH COMPOST BACTERIAL CUTINASE
JRNL        TITL 2 HOMOLOG
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    1.50 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.5.0109
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.50
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 50.00
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.6
REMARK   3   NUMBER OF REFLECTIONS             : 32818
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.158
REMARK   3   R VALUE            (WORKING SET) : 0.157
REMARK   3   FREE R VALUE                     : 0.186
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000
REMARK   3   FREE R VALUE TEST SET COUNT      : 1741
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 1.50
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 1.54
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 2374
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 99.64
REMARK   3   BIN R VALUE           (WORKING SET) : 0.1880
REMARK   3   BIN FREE R VALUE SET COUNT          : 127
REMARK   3   BIN FREE R VALUE                    : 0.2500
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 1962
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 12
REMARK   3   SOLVENT ATOMS            : 315
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 17.17
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -0.67000
REMARK   3    B22 (A**2) : -0.04000
REMARK   3    B33 (A**2) : 0.70000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : -0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.074
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.075
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.043
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 1.126
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.971
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.959
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  2023 ; 0.007 ; 0.022
REMARK   3   BOND LENGTHS OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES):  2764 ; 1.000 ; 1.941
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):   257 ; 7.429 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):    87 ;32.304 ;22.759
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):   283 ;10.840 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    16 ;12.062 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):   310 ; 0.084 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  1578 ; 0.020 ; 0.021
REMARK   3   GENERAL PLANES OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  1298 ; 1.466 ; 1.500
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  2088 ; 2.175 ; 2.000
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):   725 ; 3.398 ; 3.000
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):   676 ; 4.458 ; 4.500
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.40
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING
REMARK   3  POSITIONS
REMARK   4
REMARK   4 4EB0 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 30-MAR-12.
REMARK 100 THE RCSB ID CODE IS RCSB071392.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 10-OCT-11
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 7.0
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SPRING-8
REMARK 200  BEAMLINE                       : BL44XU
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9
REMARK 200  MONOCHROMATOR                  : HORIZONTAL FOCUSING MIRROR
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : BRUKER SMART 6500
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL
REMARK 200  DATA SCALING SOFTWARE          : HKL
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 35110
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.500
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : -3.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.9
REMARK 200  DATA REDUNDANCY                : 13.700
REMARK 200  R MERGE                    (I) : 0.10600
REMARK 200  R SYM                      (I) : 0.10600
REMARK 200   FOR THE DATA SET  : 31.6570
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.50
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.53
REMARK 200  COMPLETENESS FOR SHELL     (%) : 100.0
REMARK 200  DATA REDUNDANCY IN SHELL       : 12.70
REMARK 200  R MERGE FOR SHELL          (I) : 0.41900
REMARK 200  R SYM FOR SHELL            (I) : 0.41900
REMARK 200   FOR SHELL         : 0.419
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: MOLREP
REMARK 200 STARTING MODEL: 1JFR
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 35.33
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 1.90
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 20% (W/V) POLYETHYLENE GLYCOL (PEG)
REMARK 280  3350, 200MM SODIUM THIOCYANATE, PH 7.0, VAPOR DIFFUSION, SITTING
REMARK 280  DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X+1/2,-Y,Z+1/2
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       20.45550
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       36.36300
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       35.54200
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       36.36300
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       20.45550
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       35.54200
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    SER A 165     -127.89     60.19
REMARK 500    HIS A 218      -83.73   -126.70
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500                                 MODEL     OMEGA
REMARK 500 ILE A  119     ASN A  120                  149.22
REMARK 500
REMARK 500 REMARK: NULL
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SCN A 301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SCN A 302
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SCN A 303
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SCN A 304
DBREF  4EB0 A   36   293  UNP    G9BY57   G9BY57_9BACT    36    293
SEQRES   1 A  258  SER ASN PRO TYR GLN ARG GLY PRO ASN PRO THR ARG SER
SEQRES   2 A  258  ALA LEU THR ALA ASP GLY PRO PHE SER VAL ALA THR TYR
SEQRES   3 A  258  THR VAL SER ARG LEU SER VAL SER GLY PHE GLY GLY GLY
SEQRES   4 A  258  VAL ILE TYR TYR PRO THR GLY THR SER LEU THR PHE GLY
SEQRES   5 A  258  GLY ILE ALA MET SER PRO GLY TYR THR ALA ASP ALA SER
SEQRES   6 A  258  SER LEU ALA TRP LEU GLY ARG ARG LEU ALA SER HIS GLY
SEQRES   7 A  258  PHE VAL VAL LEU VAL ILE ASN THR ASN SER ARG PHE ASP
SEQRES   8 A  258  TYR PRO ASP SER ARG ALA SER GLN LEU SER ALA ALA LEU
SEQRES   9 A  258  ASN TYR LEU ARG THR SER SER PRO SER ALA VAL ARG ALA
SEQRES  10 A  258  ARG LEU ASP ALA ASN ARG LEU ALA VAL ALA GLY HIS SER
SEQRES  11 A  258  MET GLY GLY GLY GLY THR LEU ARG ILE ALA GLU GLN ASN
SEQRES  12 A  258  PRO SER LEU LYS ALA ALA VAL PRO LEU THR PRO TRP HIS
SEQRES  13 A  258  THR ASP LYS THR PHE ASN THR SER VAL PRO VAL LEU ILE
SEQRES  14 A  258  VAL GLY ALA GLU ALA ASP THR VAL ALA PRO VAL SER GLN
SEQRES  15 A  258  HIS ALA ILE PRO PHE TYR GLN ASN LEU PRO SER THR THR
SEQRES  16 A  258  PRO LYS VAL TYR VAL GLU LEU ASP ASN ALA SER HIS PHE
SEQRES  17 A  258  ALA PRO ASN SER ASN ASN ALA ALA ILE SER VAL TYR THR
SEQRES  18 A  258  ILE SER TRP MET LYS LEU TRP VAL ASP ASN ASP THR ARG
SEQRES  19 A  258  TYR ARG GLN PHE LEU CYS ASN VAL ASN ASP PRO ALA LEU
SEQRES  20 A  258  SER ASP PHE ARG THR ASN ASN ARG HIS CYS GLN
HET    SCN  A 301       3
HET    SCN  A 302       3
HET    SCN  A 303       3
HET    SCN  A 304       3
HETNAM     SCN THIOCYANATE ION
FORMUL   2  SCN    4(C N S 1-)
FORMUL   6  HOH   *315(H2 O)
HELIX    1   1 ARG A   47  ALA A   52  5                                   6
HELIX    2   2 SER A   64  VAL A   68  5                                   5
HELIX    3   3 ASP A   98  SER A  101  5                                   4
HELIX    4   4 LEU A  102  HIS A  112  1                                  11
HELIX    5   5 TYR A  127  SER A  145  1                                  19
HELIX    6   6 PRO A  147  ALA A  152  1                                   6
HELIX    7   7 SER A  165  ASN A  178  1                                  14
HELIX    8   8 HIS A  218  LEU A  226  1                                   9
HELIX    9   9 PHE A  243  SER A  247  5                                   5
HELIX   10  10 ASN A  249  ASP A  265  1                                  17
HELIX   11  11 ASP A  267  LEU A  274  5                                   8
HELIX   12  12 ASN A  289  GLN A  293  5                                   5
SHEET    1   A 6 VAL A  58  VAL A  63  0
SHEET    2   A 6 GLY A  74  PRO A  79 -1  O  ILE A  76   N  TYR A  61
SHEET    3   A 6 VAL A 115  ILE A 119 -1  O  VAL A 116   N  TYR A  77
SHEET    4   A 6 PHE A  86  SER A  92  1  N  ILE A  89   O  VAL A 115
SHEET    5   A 6 LEU A 154  HIS A 164  1  O  ASP A 155   N  PHE A  86
SHEET    6   A 6 ALA A 184  LEU A 187  1  O  LEU A 187   N  GLY A 163
SHEET    1   B 3 VAL A 202  ALA A 207  0
SHEET    2   B 3 LYS A 232  LEU A 237  1  O  VAL A 235   N  GLY A 206
SHEET    3   B 3 LEU A 282  THR A 287 -1  O  ARG A 286   N  TYR A 234
SSBOND   1 CYS A  275    CYS A  292                          1555   1555  2.05
SITE     1 AC1  5 GLY A  42  TYR A 223  ARG A 286  HOH A 452
SITE     2 AC1  5 HOH A 527
SITE     1 AC2  5 THR A  96  ARG A 124  PRO A 231  ARG A 290
SITE     2 AC2  5 HOH A 469
SITE     1 AC3  4 SER A  48  SER A  69  THR A 144  SER A 145
SITE     1 AC4  8 ARG A  47  ASN A 276  VAL A 277  ASN A 278
SITE     2 AC4  8 ASP A 279  HOH A 458  HOH A 493  HOH A 544
CRYST1   40.911   71.084   72.726  90.00  90.00  90.00 P 21 21 21    4
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.024443  0.000000  0.000000        0.00000
SCALE2      0.000000  0.014068  0.000000        0.00000
SCALE3      0.000000  0.000000  0.013750        0.00000
TER    1963      GLN A 293
MASTER      279    0    4   12    9    0    7    6 2289    1   14   20
END