longtext: 4EBB-pdb

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HEADER    HYDROLASE                               23-MAR-12   4EBB
TITLE     STRUCTURE OF DPP2
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: DIPEPTIDYL PEPTIDASE 2;
COMPND   3 CHAIN: A, B;
COMPND   4 FRAGMENT: DIPEPTIDYL PEPTIDASE 7 (UNP RESIDUES 27-492);
COMPND   5 SYNONYM: DIPEPTIDYL AMINOPEPTIDASE II, DIPEPTIDYL PEPTIDASE 7,
COMPND   6 DIPEPTIDYL PEPTIDASE II, DPP II, QUIESCENT CELL PROLINE DIPEPTIDASE;
COMPND   7 EC: 3.4.14.2;
COMPND   8 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE   3 ORGANISM_COMMON: HUMAN;
SOURCE   4 ORGANISM_TAXID: 9606;
SOURCE   5 GENE: DPP7, DPP2, QPP;
SOURCE   6 EXPRESSION_SYSTEM: CRICETULUS GRISEUS;
SOURCE   7 EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER;
SOURCE   8 EXPRESSION_SYSTEM_TAXID: 10029;
SOURCE   9 EXPRESSION_SYSTEM_PLASMID: PDEST
KEYWDS    PEPTIDASE, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    L.M.SHEWCHUK,A.H.HASSELL,S.M.SWEITZER,T.D.SWEITZER,P.J.MCDEVITT,
AUTHOR   2 K.M.KENNEDY-WILSON,K.O.JOHANSON
REVDAT   1   19-SEP-12 4EBB    0
JRNL        AUTH   G.A.BEZERRA,E.DOBROVETSKY,A.DONG,A.SEITOVA,L.CROMBETT,
JRNL        AUTH 2 L.M.SHEWCHUK,A.M.HASSELL,S.M.SWEITZER,T.D.SWEITZER,
JRNL        AUTH 3 P.J.MCDEVITT,K.O.JOHANSON,K.M.KENNEDY-WILSON,D.COSSAR,
JRNL        AUTH 4 A.BOCHKAREV,K.GRUBER,S.DHE-PAGANON
JRNL        TITL   STRUCTURES OF HUMAN DPP7 REVEAL THE MOLECULAR BASIS OF
JRNL        TITL 2 SPECIFIC INHIBITION AND THE ARCHITECTURAL DIVERSITY OF
JRNL        TITL 3 PROLINE-SPECIFIC PEPTIDASES.
JRNL        REF    PLOS ONE                      V.   7 43019 2012
JRNL        REFN                   ESSN 1932-6203
JRNL        PMID   22952628
JRNL        DOI    10.1371/JOURNAL.PONE.0043019
REMARK   2
REMARK   2 RESOLUTION.    2.00 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.5.0109
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.00
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 37.77
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.9
REMARK   3   NUMBER OF REFLECTIONS             : 72860
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.210
REMARK   3   R VALUE            (WORKING SET) : 0.208
REMARK   3   FREE R VALUE                     : 0.230
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000
REMARK   3   FREE R VALUE TEST SET COUNT      : 3868
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.00
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.05
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 5225
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 96.77
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2620
REMARK   3   BIN FREE R VALUE SET COUNT          : 265
REMARK   3   BIN FREE R VALUE                    : 0.2810
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 6962
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 45
REMARK   3   SOLVENT ATOMS            : 512
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 32.56
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -0.16000
REMARK   3    B22 (A**2) : 0.16000
REMARK   3    B33 (A**2) : 0.00000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.179
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.151
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.104
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 8.204
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.947
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.929
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  7249 ; 0.006 ; 0.022
REMARK   3   BOND LENGTHS OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES):  9876 ; 0.864 ; 1.944
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):   910 ; 4.694 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   355 ;31.368 ;23.183
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  1043 ;12.032 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    56 ;15.331 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  1044 ; 0.062 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  5761 ; 0.003 ; 0.021
REMARK   3   GENERAL PLANES OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  4478 ; 0.338 ; 1.500
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  7119 ; 0.651 ; 2.000
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  2771 ; 0.983 ; 3.000
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  2750 ; 1.521 ; 4.500
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 1
REMARK   3
REMARK   3   TLS GROUP : 1
REMARK   3    NUMBER OF COMPONENTS GROUP : 6
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   B   601        B   822
REMARK   3    RESIDUE RANGE :   A   601        A   890
REMARK   3    RESIDUE RANGE :   B   501        B   501
REMARK   3    RESIDUE RANGE :   A   501        A   505
REMARK   3    RESIDUE RANGE :   B    27        B   477
REMARK   3    RESIDUE RANGE :   A    28        A   477
REMARK   3    ORIGIN FOR THE GROUP (A):  52.5482  61.7161  78.5649
REMARK   3    T TENSOR
REMARK   3      T11:   0.0323 T22:   0.0507
REMARK   3      T33:   0.0545 T12:  -0.0030
REMARK   3      T13:   0.0024 T23:  -0.0002
REMARK   3    L TENSOR
REMARK   3      L11:   0.0226 L22:   0.0195
REMARK   3      L33:   0.4496 L12:   0.0116
REMARK   3      L13:   0.0707 L23:   0.0568
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0312 S12:   0.0149 S13:  -0.0089
REMARK   3      S21:  -0.0198 S22:  -0.0208 S23:   0.0034
REMARK   3      S31:  -0.0751 S32:   0.0537 S33:   0.0521
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.40
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING
REMARK   3  POSITIONS
REMARK   4
REMARK   4 4EBB COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 02-APR-12.
REMARK 100 THE RCSB ID CODE IS RCSB071403.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 15-JUL-05
REMARK 200  TEMPERATURE           (KELVIN) : 93
REMARK 200  PH                             : 4.6
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : APS
REMARK 200  BEAMLINE                       : 17-ID
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.97
REMARK 200  MONOCHROMATOR                  : SI
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 210
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : DENZO
REMARK 200  DATA SCALING SOFTWARE          : SCALEPACK
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 72860
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.000
REMARK 200  RESOLUTION RANGE LOW       (A) : 37.770
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 2.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.9
REMARK 200  DATA REDUNDANCY                : 3.400
REMARK 200  R MERGE                    (I) : 0.07900
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 20.0000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.00
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.05
REMARK 200  COMPLETENESS FOR SHELL     (%) : 96.8
REMARK 200  DATA REDUNDANCY IN SHELL       : 3.00
REMARK 200  R MERGE FOR SHELL          (I) : 0.47500
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 2.000
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: SAD
REMARK 200 SOFTWARE USED: SHARP
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 54.07
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.68
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1M SODIUM ACETATE, 0.05M ZINC
REMARK 280  ACETATE, 5% PEG3350, PH 4.6, VAPOR DIFFUSION, HANGING DROP,
REMARK 280  TEMPERATURE 295K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X+1/2,-Y,Z+1/2
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       30.54450
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       96.06850
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       48.22350
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       96.06850
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       30.54450
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       48.22350
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3, 4
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 3
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 2340 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 35360 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -84.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   2  1.000000  0.000000  0.000000       30.54450
REMARK 350   BIOMT2   2  0.000000 -1.000000  0.000000      144.67050
REMARK 350   BIOMT3   2  0.000000  0.000000 -1.000000      192.13700
REMARK 350
REMARK 350 BIOMOLECULE: 4
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 5440 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 32260 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -59.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   2 -1.000000  0.000000  0.000000       91.63350
REMARK 350   BIOMT2   2  0.000000 -1.000000  0.000000       96.44700
REMARK 350   BIOMT3   2  0.000000  0.000000  1.000000       96.06850
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     PRO A    27
REMARK 465     ARG A   478
REMARK 465     GLU A   479
REMARK 465     GLN A   480
REMARK 465     GLN A   481
REMARK 465     PRO A   482
REMARK 465     ALA A   483
REMARK 465     LEU A   484
REMARK 465     ARG A   485
REMARK 465     GLY A   486
REMARK 465     GLY A   487
REMARK 465     PRO A   488
REMARK 465     ARG A   489
REMARK 465     LEU A   490
REMARK 465     SER A   491
REMARK 465     LEU A   492
REMARK 465     GLU A   493
REMARK 465     ASN A   494
REMARK 465     LEU A   495
REMARK 465     TYR A   496
REMARK 465     PHE A   497
REMARK 465     GLN A   498
REMARK 465     GLY B    67
REMARK 465     GLU B    68
REMARK 465     ARG B   478
REMARK 465     GLU B   479
REMARK 465     GLN B   480
REMARK 465     GLN B   481
REMARK 465     PRO B   482
REMARK 465     ALA B   483
REMARK 465     LEU B   484
REMARK 465     ARG B   485
REMARK 465     GLY B   486
REMARK 465     GLY B   487
REMARK 465     PRO B   488
REMARK 465     ARG B   489
REMARK 465     LEU B   490
REMARK 465     SER B   491
REMARK 465     LEU B   492
REMARK 465     GLU B   493
REMARK 465     ASN B   494
REMARK 465     LEU B   495
REMARK 465     TYR B   496
REMARK 465     PHE B   497
REMARK 465     GLN B   498
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     ARG A  66    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ALA A  89    CB
REMARK 470     LYS A 215    CE   NZ
REMARK 470     ARG A 225    NE   CZ   NH1  NH2
REMARK 470     LYS A 253    CE   NZ
REMARK 470     LEU A 281    CG   CD1  CD2
REMARK 470     ARG A 380    NE   CZ   NH1  NH2
REMARK 470     ARG A 427    NE   CZ   NH1  NH2
REMARK 470     ARG A 477    NE   CZ   NH1  NH2
REMARK 470     PRO B  27    CG   CD
REMARK 470     ARG B  66    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ALA B  89    CB
REMARK 470     ARG B 225    NE   CZ   NH1  NH2
REMARK 470     GLN B 247    CG   CD   OE1  NE2
REMARK 470     GLU B 252    CG   CD   OE1  OE2
REMARK 470     LYS B 253    CG   CD   CE   NZ
REMARK 470     LEU B 281    CG   CD1  CD2
REMARK 470     THR B 340    OG1  CG2
REMARK 470     PHE B 373    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     ASP B 375    CG   OD1  OD2
REMARK 470     GLU B 376    CG   CD   OE1  OE2
REMARK 470     ARG B 380    CG   CD   NE   CZ   NH1  NH2
REMARK 470     TRP B 389    CG   CD1  CD2  NE1  CE2  CE3  CZ2
REMARK 470     TRP B 389    CZ3  CH2
REMARK 470     LYS B 474    CE   NZ
REMARK 470     ARG B 477    CG   CD   NE   CZ   NH1  NH2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    GLU A  68      -51.32   -128.43
REMARK 500    ASN A  77     -146.11   -110.10
REMARK 500    GLU A  78       47.65    -76.23
REMARK 500    TYR A 109       -4.49     79.35
REMARK 500    SER A 113       75.88   -102.66
REMARK 500    SER A 162     -130.35     64.67
REMARK 500    SER A 250      -25.00   -146.04
REMARK 500    PHE A 280      -71.48    -86.39
REMARK 500    ASN A 315       36.64   -143.25
REMARK 500    THR A 353      -69.00   -124.79
REMARK 500    VAL A 364      -55.28   -123.59
REMARK 500    TRP A 400       -7.80     78.81
REMARK 500    ALA A 442     -135.93    -95.59
REMARK 500    HIS A 444       53.22     39.01
REMARK 500    ASN B  77     -141.94   -112.69
REMARK 500    GLU B  78       48.01    -81.26
REMARK 500    SER B  88       58.27   -118.16
REMARK 500    TYR B 109       -3.59     80.76
REMARK 500    SER B 162     -128.75     66.72
REMARK 500    SER B 250      -43.49   -148.92
REMARK 500    ASN B 315       43.87   -140.87
REMARK 500    THR B 353      -69.72   -125.39
REMARK 500    VAL B 364      -54.82   -120.32
REMARK 500    TRP B 400      -15.02     80.79
REMARK 500    ALA B 442     -135.73    -96.48
REMARK 500    HIS B 444       57.09     36.99
REMARK 500
REMARK 500 REMARK: NULL
REMARK 620
REMARK 620 METAL COORDINATION
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              ZN A 504  ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 GLU A 453   OE1
REMARK 620 2 HIS A 451   ND1 104.6
REMARK 620 N                    1
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAG A 501
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAG A 502
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN A 503
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN A 504
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN A 505
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAG B 501
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 3JYH   RELATED DB: PDB
DBREF  4EBB A   27   492  UNP    Q9UHL4   DPP2_HUMAN      27    492
DBREF  4EBB B   27   492  UNP    Q9UHL4   DPP2_HUMAN      27    492
SEQADV 4EBB GLU A  493  UNP  Q9UHL4              EXPRESSION TAG
SEQADV 4EBB ASN A  494  UNP  Q9UHL4              EXPRESSION TAG
SEQADV 4EBB LEU A  495  UNP  Q9UHL4              EXPRESSION TAG
SEQADV 4EBB TYR A  496  UNP  Q9UHL4              EXPRESSION TAG
SEQADV 4EBB PHE A  497  UNP  Q9UHL4              EXPRESSION TAG
SEQADV 4EBB GLN A  498  UNP  Q9UHL4              EXPRESSION TAG
SEQADV 4EBB GLU B  493  UNP  Q9UHL4              EXPRESSION TAG
SEQADV 4EBB ASN B  494  UNP  Q9UHL4              EXPRESSION TAG
SEQADV 4EBB LEU B  495  UNP  Q9UHL4              EXPRESSION TAG
SEQADV 4EBB TYR B  496  UNP  Q9UHL4              EXPRESSION TAG
SEQADV 4EBB PHE B  497  UNP  Q9UHL4              EXPRESSION TAG
SEQADV 4EBB GLN B  498  UNP  Q9UHL4              EXPRESSION TAG
SEQRES   1 A  472  PRO ASP PRO GLY PHE GLN GLU ARG PHE PHE GLN GLN ARG
SEQRES   2 A  472  LEU ASP HIS PHE ASN PHE GLU ARG PHE GLY ASN LYS THR
SEQRES   3 A  472  PHE PRO GLN ARG PHE LEU VAL SER ASP ARG PHE TRP VAL
SEQRES   4 A  472  ARG GLY GLU GLY PRO ILE PHE PHE TYR THR GLY ASN GLU
SEQRES   5 A  472  GLY ASP VAL TRP ALA PHE ALA ASN ASN SER ALA PHE VAL
SEQRES   6 A  472  ALA GLU LEU ALA ALA GLU ARG GLY ALA LEU LEU VAL PHE
SEQRES   7 A  472  ALA GLU HIS ARG TYR TYR GLY LYS SER LEU PRO PHE GLY
SEQRES   8 A  472  ALA GLN SER THR GLN ARG GLY HIS THR GLU LEU LEU THR
SEQRES   9 A  472  VAL GLU GLN ALA LEU ALA ASP PHE ALA GLU LEU LEU ARG
SEQRES  10 A  472  ALA LEU ARG ARG ASP LEU GLY ALA GLN ASP ALA PRO ALA
SEQRES  11 A  472  ILE ALA PHE GLY GLY SER TYR GLY GLY MSE LEU SER ALA
SEQRES  12 A  472  TYR LEU ARG MSE LYS TYR PRO HIS LEU VAL ALA GLY ALA
SEQRES  13 A  472  LEU ALA ALA SER ALA PRO VAL LEU ALA VAL ALA GLY LEU
SEQRES  14 A  472  GLY ASP SER ASN GLN PHE PHE ARG ASP VAL THR ALA ASP
SEQRES  15 A  472  PHE GLU GLY GLN SER PRO LYS CYS THR GLN GLY VAL ARG
SEQRES  16 A  472  GLU ALA PHE ARG GLN ILE LYS ASP LEU PHE LEU GLN GLY
SEQRES  17 A  472  ALA TYR ASP THR VAL ARG TRP GLU PHE GLY THR CYS GLN
SEQRES  18 A  472  PRO LEU SER ASP GLU LYS ASP LEU THR GLN LEU PHE MSE
SEQRES  19 A  472  PHE ALA ARG ASN ALA PHE THR VAL LEU ALA MSE MSE ASP
SEQRES  20 A  472  TYR PRO TYR PRO THR ASP PHE LEU GLY PRO LEU PRO ALA
SEQRES  21 A  472  ASN PRO VAL LYS VAL GLY CYS ASP ARG LEU LEU SER GLU
SEQRES  22 A  472  ALA GLN ARG ILE THR GLY LEU ARG ALA LEU ALA GLY LEU
SEQRES  23 A  472  VAL TYR ASN ALA SER GLY SER GLU HIS CYS TYR ASP ILE
SEQRES  24 A  472  TYR ARG LEU TYR HIS SER CYS ALA ASP PRO THR GLY CYS
SEQRES  25 A  472  GLY THR GLY PRO ASP ALA ARG ALA TRP ASP TYR GLN ALA
SEQRES  26 A  472  CYS THR GLU ILE ASN LEU THR PHE ALA SER ASN ASN VAL
SEQRES  27 A  472  THR ASP MSE PHE PRO ASP LEU PRO PHE THR ASP GLU LEU
SEQRES  28 A  472  ARG GLN ARG TYR CYS LEU ASP THR TRP GLY VAL TRP PRO
SEQRES  29 A  472  ARG PRO ASP TRP LEU LEU THR SER PHE TRP GLY GLY ASP
SEQRES  30 A  472  LEU ARG ALA ALA SER ASN ILE ILE PHE SER ASN GLY ASN
SEQRES  31 A  472  LEU ASP PRO TRP ALA GLY GLY GLY ILE ARG ARG ASN LEU
SEQRES  32 A  472  SER ALA SER VAL ILE ALA VAL THR ILE GLN GLY GLY ALA
SEQRES  33 A  472  HIS HIS LEU ASP LEU ARG ALA SER HIS PRO GLU ASP PRO
SEQRES  34 A  472  ALA SER VAL VAL GLU ALA ARG LYS LEU GLU ALA THR ILE
SEQRES  35 A  472  ILE GLY GLU TRP VAL LYS ALA ALA ARG ARG GLU GLN GLN
SEQRES  36 A  472  PRO ALA LEU ARG GLY GLY PRO ARG LEU SER LEU GLU ASN
SEQRES  37 A  472  LEU TYR PHE GLN
SEQRES   1 B  472  PRO ASP PRO GLY PHE GLN GLU ARG PHE PHE GLN GLN ARG
SEQRES   2 B  472  LEU ASP HIS PHE ASN PHE GLU ARG PHE GLY ASN LYS THR
SEQRES   3 B  472  PHE PRO GLN ARG PHE LEU VAL SER ASP ARG PHE TRP VAL
SEQRES   4 B  472  ARG GLY GLU GLY PRO ILE PHE PHE TYR THR GLY ASN GLU
SEQRES   5 B  472  GLY ASP VAL TRP ALA PHE ALA ASN ASN SER ALA PHE VAL
SEQRES   6 B  472  ALA GLU LEU ALA ALA GLU ARG GLY ALA LEU LEU VAL PHE
SEQRES   7 B  472  ALA GLU HIS ARG TYR TYR GLY LYS SER LEU PRO PHE GLY
SEQRES   8 B  472  ALA GLN SER THR GLN ARG GLY HIS THR GLU LEU LEU THR
SEQRES   9 B  472  VAL GLU GLN ALA LEU ALA ASP PHE ALA GLU LEU LEU ARG
SEQRES  10 B  472  ALA LEU ARG ARG ASP LEU GLY ALA GLN ASP ALA PRO ALA
SEQRES  11 B  472  ILE ALA PHE GLY GLY SER TYR GLY GLY MSE LEU SER ALA
SEQRES  12 B  472  TYR LEU ARG MSE LYS TYR PRO HIS LEU VAL ALA GLY ALA
SEQRES  13 B  472  LEU ALA ALA SER ALA PRO VAL LEU ALA VAL ALA GLY LEU
SEQRES  14 B  472  GLY ASP SER ASN GLN PHE PHE ARG ASP VAL THR ALA ASP
SEQRES  15 B  472  PHE GLU GLY GLN SER PRO LYS CYS THR GLN GLY VAL ARG
SEQRES  16 B  472  GLU ALA PHE ARG GLN ILE LYS ASP LEU PHE LEU GLN GLY
SEQRES  17 B  472  ALA TYR ASP THR VAL ARG TRP GLU PHE GLY THR CYS GLN
SEQRES  18 B  472  PRO LEU SER ASP GLU LYS ASP LEU THR GLN LEU PHE MSE
SEQRES  19 B  472  PHE ALA ARG ASN ALA PHE THR VAL LEU ALA MSE MSE ASP
SEQRES  20 B  472  TYR PRO TYR PRO THR ASP PHE LEU GLY PRO LEU PRO ALA
SEQRES  21 B  472  ASN PRO VAL LYS VAL GLY CYS ASP ARG LEU LEU SER GLU
SEQRES  22 B  472  ALA GLN ARG ILE THR GLY LEU ARG ALA LEU ALA GLY LEU
SEQRES  23 B  472  VAL TYR ASN ALA SER GLY SER GLU HIS CYS TYR ASP ILE
SEQRES  24 B  472  TYR ARG LEU TYR HIS SER CYS ALA ASP PRO THR GLY CYS
SEQRES  25 B  472  GLY THR GLY PRO ASP ALA ARG ALA TRP ASP TYR GLN ALA
SEQRES  26 B  472  CYS THR GLU ILE ASN LEU THR PHE ALA SER ASN ASN VAL
SEQRES  27 B  472  THR ASP MSE PHE PRO ASP LEU PRO PHE THR ASP GLU LEU
SEQRES  28 B  472  ARG GLN ARG TYR CYS LEU ASP THR TRP GLY VAL TRP PRO
SEQRES  29 B  472  ARG PRO ASP TRP LEU LEU THR SER PHE TRP GLY GLY ASP
SEQRES  30 B  472  LEU ARG ALA ALA SER ASN ILE ILE PHE SER ASN GLY ASN
SEQRES  31 B  472  LEU ASP PRO TRP ALA GLY GLY GLY ILE ARG ARG ASN LEU
SEQRES  32 B  472  SER ALA SER VAL ILE ALA VAL THR ILE GLN GLY GLY ALA
SEQRES  33 B  472  HIS HIS LEU ASP LEU ARG ALA SER HIS PRO GLU ASP PRO
SEQRES  34 B  472  ALA SER VAL VAL GLU ALA ARG LYS LEU GLU ALA THR ILE
SEQRES  35 B  472  ILE GLY GLU TRP VAL LYS ALA ALA ARG ARG GLU GLN GLN
SEQRES  36 B  472  PRO ALA LEU ARG GLY GLY PRO ARG LEU SER LEU GLU ASN
SEQRES  37 B  472  LEU TYR PHE GLN
MODRES 4EBB ASN A  315  ASN  GLYCOSYLATION SITE
MODRES 4EBB ASN A  363  ASN  GLYCOSYLATION SITE
MODRES 4EBB ASN B  363  ASN  GLYCOSYLATION SITE
MODRES 4EBB MSE A  166  MET  SELENOMETHIONINE
MODRES 4EBB MSE A  173  MET  SELENOMETHIONINE
MODRES 4EBB MSE A  260  MET  SELENOMETHIONINE
MODRES 4EBB MSE A  271  MET  SELENOMETHIONINE
MODRES 4EBB MSE A  272  MET  SELENOMETHIONINE
MODRES 4EBB MSE A  367  MET  SELENOMETHIONINE
MODRES 4EBB MSE B  166  MET  SELENOMETHIONINE
MODRES 4EBB MSE B  173  MET  SELENOMETHIONINE
MODRES 4EBB MSE B  260  MET  SELENOMETHIONINE
MODRES 4EBB MSE B  271  MET  SELENOMETHIONINE
MODRES 4EBB MSE B  272  MET  SELENOMETHIONINE
MODRES 4EBB MSE B  367  MET  SELENOMETHIONINE
HET    MSE  A 166       8
HET    MSE  A 173       8
HET    MSE  A 260      13
HET    MSE  A 271       8
HET    MSE  A 272      13
HET    MSE  A 367       8
HET    MSE  B 166       8
HET    MSE  B 173       8
HET    MSE  B 260       8
HET    MSE  B 271       8
HET    MSE  B 272       8
HET    MSE  B 367       8
HET    NAG  A 501      14
HET    NAG  A 502      14
HET     ZN  A 503       1
HET     ZN  A 504       1
HET     ZN  A 505       1
HET    NAG  B 501      14
HETNAM     MSE SELENOMETHIONINE
HETNAM     NAG N-ACETYL-D-GLUCOSAMINE
HETNAM      ZN ZINC ION
FORMUL   1  MSE    12(C5 H11 N O2 SE)
FORMUL   3  NAG    3(C8 H15 N O6)
FORMUL   5   ZN    3(ZN 2+)
FORMUL   9  HOH   *512(H2 O)
HELIX    1   1 ASP A   80  SER A   88  1                                   9
HELIX    2   2 SER A   88  GLY A   99  1                                  12
HELIX    3   3 PHE A  116  GLN A  122  5                                   7
HELIX    4   4 THR A  130  LEU A  149  1                                  20
HELIX    5   5 SER A  162  TYR A  175  1                                  14
HELIX    6   6 LEU A  190  GLY A  194  5                                   5
HELIX    7   7 ASN A  199  GLY A  211  1                                  13
HELIX    8   8 SER A  213  GLY A  234  1                                  22
HELIX    9   9 ALA A  235  GLY A  244  1                                  10
HELIX   10  10 ASP A  251  MSE A  272  1                                  22
HELIX   11  11 ASN A  287  SER A  298  1                                  12
HELIX   12  12 GLN A  301  ASN A  315  1                                  15
HELIX   13  13 ASP A  324  TYR A  329  1                                   6
HELIX   14  14 GLY A  341  CYS A  352  1                                  12
HELIX   15  15 THR A  374  GLY A  387  1                                  14
HELIX   16  16 ASP A  393  TRP A  400  1                                   8
HELIX   17  17 TRP A  420  GLY A  424  5                                   5
HELIX   18  18 HIS A  444  ARG A  448  5                                   5
HELIX   19  19 PRO A  455  ARG A  477  1                                  23
HELIX   20  20 ASP B   80  SER B   88  1                                   9
HELIX   21  21 SER B   88  GLY B   99  1                                  12
HELIX   22  22 PHE B  116  GLN B  122  5                                   7
HELIX   23  23 THR B  130  LEU B  149  1                                  20
HELIX   24  24 SER B  162  TYR B  175  1                                  14
HELIX   25  25 LEU B  190  GLY B  194  5                                   5
HELIX   26  26 ASN B  199  SER B  213  1                                  15
HELIX   27  27 SER B  213  GLY B  234  1                                  22
HELIX   28  28 ALA B  235  GLY B  244  1                                  10
HELIX   29  29 ASP B  251  MSE B  272  1                                  22
HELIX   30  30 ASN B  287  SER B  298  1                                  12
HELIX   31  31 GLN B  301  ASN B  315  1                                  15
HELIX   32  32 ASP B  324  TYR B  329  1                                   6
HELIX   33  33 GLY B  341  CYS B  352  1                                  12
HELIX   34  34 THR B  374  GLY B  387  1                                  14
HELIX   35  35 ASP B  393  TRP B  400  1                                   8
HELIX   36  36 TRP B  420  GLY B  424  5                                   5
HELIX   37  37 HIS B  444  ARG B  448  5                                   5
HELIX   38  38 PRO B  455  ARG B  477  1                                  23
SHEET    1   A 8 GLN A  32  ARG A  39  0
SHEET    2   A 8 THR A  52  SER A  60 -1  O  PHE A  53   N  GLN A  38
SHEET    3   A 8 LEU A 101  ALA A 105 -1  O  PHE A 104   N  LEU A  58
SHEET    4   A 8 ILE A  71  THR A  75  1  N  PHE A  72   O  LEU A 101
SHEET    5   A 8 ALA A 156  GLY A 161  1  O  ILE A 157   N  ILE A  71
SHEET    6   A 8 GLY A 181  ALA A 185  1  O  ALA A 185   N  GLY A 160
SHEET    7   A 8 ILE A 410  GLY A 415  1  O  ILE A 411   N  ALA A 184
SHEET    8   A 8 VAL A 433  ILE A 438  1  O  ILE A 434   N  PHE A 412
SHEET    1   B 2 THR A 278  ASP A 279  0
SHEET    2   B 2 PRO A 283  LEU A 284 -1  O  LEU A 284   N  THR A 278
SHEET    1   C 8 GLN B  32  ARG B  39  0
SHEET    2   C 8 THR B  52  SER B  60 -1  O  GLN B  55   N  PHE B  36
SHEET    3   C 8 LEU B 101  ALA B 105 -1  O  PHE B 104   N  LEU B  58
SHEET    4   C 8 ILE B  71  THR B  75  1  N  PHE B  72   O  LEU B 101
SHEET    5   C 8 ALA B 156  GLY B 161  1  O  ILE B 157   N  PHE B  73
SHEET    6   C 8 GLY B 181  ALA B 185  1  O  LEU B 183   N  ALA B 158
SHEET    7   C 8 ILE B 410  GLY B 415  1  O  ILE B 411   N  ALA B 184
SHEET    8   C 8 VAL B 433  ILE B 438  1  O  ILE B 434   N  PHE B 412
SHEET    1   D 2 THR B 278  ASP B 279  0
SHEET    2   D 2 PRO B 283  LEU B 284 -1  O  LEU B 284   N  THR B 278
SSBOND   1 CYS A  216    CYS A  293                          1555   1555  2.03
SSBOND   2 CYS A  246    CYS A  322                          1555   1555  2.04
SSBOND   3 CYS A  332    CYS A  338                          1555   1555  2.03
SSBOND   4 CYS A  352    CYS A  382                          1555   1555  2.03
SSBOND   5 CYS B  216    CYS B  293                          1555   1555  2.03
SSBOND   6 CYS B  246    CYS B  322                          1555   1555  2.03
SSBOND   7 CYS B  332    CYS B  338                          1555   1555  2.03
SSBOND   8 CYS B  352    CYS B  382                          1555   1555  2.03
LINK         C   GLY A 165                 N   MSE A 166     1555   1555  1.33
LINK         C   MSE A 166                 N   LEU A 167     1555   1555  1.33
LINK         C   ARG A 172                 N   MSE A 173     1555   1555  1.33
LINK         C   MSE A 173                 N   LYS A 174     1555   1555  1.33
LINK         C   PHE A 259                 N   MSE A 260     1555   1555  1.33
LINK         C   MSE A 260                 N   PHE A 261     1555   1555  1.33
LINK         C   ALA A 270                 N   MSE A 271     1555   1555  1.33
LINK         C   MSE A 271                 N   MSE A 272     1555   1555  1.33
LINK         C   MSE A 272                 N   ASP A 273     1555   1555  1.33
LINK         C   ASP A 366                 N   MSE A 367     1555   1555  1.33
LINK         C   MSE A 367                 N   PHE A 368     1555   1555  1.33
LINK         C   GLY B 165                 N   MSE B 166     1555   1555  1.34
LINK         C   MSE B 166                 N   LEU B 167     1555   1555  1.33
LINK         C   ARG B 172                 N   MSE B 173     1555   1555  1.33
LINK         C   MSE B 173                 N   LYS B 174     1555   1555  1.33
LINK         C   PHE B 259                 N   MSE B 260     1555   1555  1.33
LINK         C   MSE B 260                 N   PHE B 261     1555   1555  1.33
LINK         C   ALA B 270                 N   MSE B 271     1555   1555  1.33
LINK         C   MSE B 271                 N   MSE B 272     1555   1555  1.33
LINK         C   MSE B 272                 N   ASP B 273     1555   1555  1.33
LINK         C   ASP B 366                 N   MSE B 367     1555   1555  1.33
LINK         C   MSE B 367                 N   PHE B 368     1555   1555  1.33
LINK         ND2 ASN A 315                 C1  NAG A 501     1555   1555  1.44
LINK         ND2 ASN A 363                 C1  NAG A 502     1555   1555  1.44
LINK         ND2 ASN B 363                 C1  NAG B 501     1555   1555  1.44
LINK         OE1 GLU A 453                ZN    ZN A 504     1555   1555  1.99
LINK         NE2 HIS A 125                ZN    ZN A 503     1555   1555  2.07
LINK         ND1 HIS A 451                ZN    ZN A 504     1555   1555  2.17
LINK         OD2 ASP A 251                ZN    ZN A 505     1555   1555  2.20
SITE     1 AC1  8 ARG A 307  ASN A 315  GLY A 318  GLU A 320
SITE     2 AC1  8 TYR A 323  HOH A 716  HOH A 764  HOH A 871
SITE     1 AC2  7 PHE A 224  ARG A 225  LYS A 228  ASN A 363
SITE     2 AC2  7 HOH A 615  HOH A 781  HOH A 829
SITE     1 AC3  4 GLN A 119  HIS A 125  ASP B 279  HOH B 810
SITE     1 AC4  4 HIS A 321  HIS A 451  GLU A 453  HOH A 851
SITE     1 AC5  1 ASP A 251
SITE     1 AC6  6 PHE B 224  ARG B 225  LYS B 228  ASN B 363
SITE     2 AC6  6 HOH B 732  HOH B 786
CRYST1   61.089   96.447  192.137  90.00  90.00  90.00 P 21 21 21    8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.016370  0.000000  0.000000        0.00000
SCALE2      0.000000  0.010368  0.000000        0.00000
SCALE3      0.000000  0.000000  0.005205        0.00000
TER    3536      ARG A 477
TER    6997      ARG B 477
MASTER      455    0   18   38   20    0    9    6 7519    2  194   74
END