longtext: 4EUS-pdb

content
HEADER    HYDROLASE                               25-APR-12   4EUS
TITLE     CRYSTAL STRUCTURE OF THE CFTR INHIBITORY FACTOR CIF BOUND TO 1,2-
TITLE    2 HEXANEDIOL
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: PUTATIVE HYDROLASE;
COMPND   3 CHAIN: A, B, C, D;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: PSEUDOMONAS AERUGINOSA;
SOURCE   3 ORGANISM_TAXID: 208963;
SOURCE   4 STRAIN: UCBPP-PA14;
SOURCE   5 GENE: PA14_26090;
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: TOP10;
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PMQ70
KEYWDS    ALPHA BETA HYDROLASE, EPOXIDE HYDROLASE, SECRETED, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    C.D.BAHL,D.R.MADDEN
REVDAT   1   07-AUG-13 4EUS    0
JRNL        AUTH   C.D.BAHL,D.R.MADDEN
JRNL        TITL   CIF EPOXIDE HYDROLASE ENZYME ACTIVITY IS REQUIRED FOR CFTR
JRNL        TITL 2 INHIBITORY ACTIVITY
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    1.65 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX (PHENIX.REFINE: 1.7.3_928)
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VICENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-
REMARK   3               : KUNSTLEVE,LI-WEI HUNG,ROBERT IMMORMINO,
REMARK   3               : TOM IOERGER,AIRLIE MCCOY,ERIK MCKEE,NIGEL
REMARK   3               : MORIARTY,REETAL PAI,RANDY READ,JANE
REMARK   3               : RICHARDSON,DAVID RICHARDSON,TOD ROMO,JIM
REMARK   3               : SACCHETTINI,NICHOLAS SAUTER,JACOB SMITH,
REMARK   3               : LAURENT STORONI,TOM TERWILLIGER,PETER
REMARK   3               : ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : MLHL
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.65
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 46.45
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.990
REMARK   3   COMPLETENESS FOR RANGE        (%) : 100.0
REMARK   3   NUMBER OF REFLECTIONS             : 149955
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.170
REMARK   3   R VALUE            (WORKING SET) : 0.169
REMARK   3   FREE R VALUE                     : 0.197
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.010
REMARK   3   FREE R VALUE TEST SET COUNT      : 7520
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 46.4679 -  5.1247    0.99     4760   376  0.1858 0.1888
REMARK   3     2  5.1247 -  4.0684    1.00     5062     0  0.1263 0.0000
REMARK   3     3  4.0684 -  3.5544    1.00     4654   376  0.1509 0.1746
REMARK   3     4  3.5544 -  3.2295    1.00     4639   376  0.1567 0.1882
REMARK   3     5  3.2295 -  2.9980    1.00     5020     0  0.1718 0.0000
REMARK   3     6  2.9980 -  2.8213    1.00     4637   376  0.1712 0.1913
REMARK   3     7  2.8213 -  2.6800    1.00     4644   376  0.1655 0.1833
REMARK   3     8  2.6800 -  2.5634    1.00     4985     0  0.1638 0.0000
REMARK   3     9  2.5634 -  2.4647    1.00     4636   376  0.1653 0.1879
REMARK   3    10  2.4647 -  2.3797    1.00     4619   376  0.1672 0.1901
REMARK   3    11  2.3797 -  2.3052    1.00     4979     0  0.1615 0.0000
REMARK   3    12  2.3052 -  2.2394    1.00     4643   376  0.1733 0.2146
REMARK   3    13  2.2394 -  2.1804    1.00     4626   376  0.1654 0.2013
REMARK   3    14  2.1804 -  2.1272    1.00     5004     0  0.1618 0.0000
REMARK   3    15  2.1272 -  2.0788    1.00     4596   376  0.1638 0.1844
REMARK   3    16  2.0788 -  2.0346    1.00     4610   376  0.1643 0.1965
REMARK   3    17  2.0346 -  1.9939    1.00     4977     0  0.1639 0.0000
REMARK   3    18  1.9939 -  1.9563    1.00     4581   376  0.1654 0.1938
REMARK   3    19  1.9563 -  1.9213    1.00     4631   376  0.1638 0.1919
REMARK   3    20  1.9213 -  1.8888    1.00     4992     0  0.1748 0.0000
REMARK   3    21  1.8888 -  1.8583    1.00     4569   376  0.1864 0.2222
REMARK   3    22  1.8583 -  1.8297    1.00     4646   376  0.1909 0.2288
REMARK   3    23  1.8297 -  1.8028    1.00     4977     0  0.1863 0.0000
REMARK   3    24  1.8028 -  1.7774    1.00     4617   376  0.2026 0.2234
REMARK   3    25  1.7774 -  1.7534    1.00     4541   376  0.2020 0.2272
REMARK   3    26  1.7534 -  1.7306    1.00     4986     0  0.2138 0.0000
REMARK   3    27  1.7306 -  1.7090    1.00     4616   376  0.2247 0.2446
REMARK   3    28  1.7090 -  1.6884    1.00     4552   376  0.2343 0.2659
REMARK   3    29  1.6884 -  1.6688    1.00     5003     0  0.2347 0.0000
REMARK   3    30  1.6688 -  1.6500    1.00     4633   376  0.2458 0.2828
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.00
REMARK   3   SHRINKAGE RADIUS   : 0.73
REMARK   3   K_SOL              : 0.32
REMARK   3   B_SOL              : 33.49
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.220
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 17.020
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -0.85060
REMARK   3    B22 (A**2) : -1.36040
REMARK   3    B33 (A**2) : 2.21090
REMARK   3    B12 (A**2) : -0.00000
REMARK   3    B13 (A**2) : 0.40120
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.006           9776
REMARK   3   ANGLE     :  1.061          13278
REMARK   3   CHIRALITY :  0.077           1371
REMARK   3   PLANARITY :  0.005           1750
REMARK   3   DIHEDRAL  : 13.441           3570
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 4
REMARK   3   TLS GROUP : 1
REMARK   3    SELECTION: (chain A and resid 25:317)
REMARK   3    ORIGIN FOR THE GROUP (A):  21.9278  12.3684 -27.4424
REMARK   3    T TENSOR
REMARK   3      T11:   0.0800 T22:   0.0814
REMARK   3      T33:   0.0608 T12:   0.0012
REMARK   3      T13:   0.0118 T23:  -0.0051
REMARK   3    L TENSOR
REMARK   3      L11:   0.5993 L22:   0.6217
REMARK   3      L33:   0.6191 L12:   0.0434
REMARK   3      L13:   0.0725 L23:  -0.0366
REMARK   3    S TENSOR
REMARK   3      S11:   0.0030 S12:   0.0631 S13:  -0.0529
REMARK   3      S21:  -0.0484 S22:  -0.0191 S23:  -0.0628
REMARK   3      S31:   0.0766 S32:   0.0604 S33:   0.0100
REMARK   3   TLS GROUP : 2
REMARK   3    SELECTION: (chain B and resid 25:317)
REMARK   3    ORIGIN FOR THE GROUP (A):  31.0711  51.3549 -15.8003
REMARK   3    T TENSOR
REMARK   3      T11:   0.0708 T22:   0.0618
REMARK   3      T33:   0.0862 T12:  -0.0137
REMARK   3      T13:  -0.0177 T23:   0.0061
REMARK   3    L TENSOR
REMARK   3      L11:   0.8047 L22:   0.7015
REMARK   3      L33:   0.3728 L12:   0.2526
REMARK   3      L13:  -0.0256 L23:   0.0485
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0185 S12:   0.0213 S13:   0.1201
REMARK   3      S21:   0.0361 S22:   0.0063 S23:  -0.0315
REMARK   3      S31:  -0.0619 S32:  -0.0026 S33:   0.0057
REMARK   3   TLS GROUP : 3
REMARK   3    SELECTION: (chain C and resid 25:317)
REMARK   3    ORIGIN FOR THE GROUP (A):  -5.6619  44.3894 -27.2750
REMARK   3    T TENSOR
REMARK   3      T11:   0.0629 T22:   0.0543
REMARK   3      T33:   0.0717 T12:  -0.0019
REMARK   3      T13:   0.0038 T23:  -0.0023
REMARK   3    L TENSOR
REMARK   3      L11:   0.5488 L22:   0.7523
REMARK   3      L33:   0.7013 L12:  -0.0164
REMARK   3      L13:   0.0400 L23:  -0.0926
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0048 S12:   0.0143 S13:   0.0844
REMARK   3      S21:  -0.0155 S22:  -0.0145 S23:   0.0923
REMARK   3      S31:  -0.0840 S32:  -0.0528 S33:   0.0105
REMARK   3   TLS GROUP : 4
REMARK   3    SELECTION: (chain D and resid 25:317)
REMARK   3    ORIGIN FOR THE GROUP (A): -14.7063   5.4248 -15.7749
REMARK   3    T TENSOR
REMARK   3      T11:   0.0532 T22:   0.0642
REMARK   3      T33:   0.0466 T12:  -0.0237
REMARK   3      T13:   0.0071 T23:   0.0015
REMARK   3    L TENSOR
REMARK   3      L11:   0.7399 L22:   0.5389
REMARK   3      L33:   0.3630 L12:   0.0786
REMARK   3      L13:  -0.0360 L23:  -0.1175
REMARK   3    S TENSOR
REMARK   3      S11:   0.0160 S12:   0.0066 S13:  -0.0444
REMARK   3      S21:  -0.0076 S22:  -0.0014 S23:   0.0740
REMARK   3      S31:   0.0223 S32:  -0.0070 S33:  -0.0093
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 4EUS COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 01-MAY-12.
REMARK 100 THE RCSB ID CODE IS RCSB072094.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 24-FEB-12
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : NSLS
REMARK 200  BEAMLINE                       : X6A
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.0000
REMARK 200  MONOCHROMATOR                  : SI(111) CHANNEL CUT MONOCHROMATOR
REMARK 200  OPTICS                         : TOROIDAL FOCUSING MIRROR
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 270
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS-PACKAGE
REMARK 200  DATA SCALING SOFTWARE          : XDS-PACKAGE
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 149966
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.650
REMARK 200  RESOLUTION RANGE LOW       (A) : 46.450
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.9
REMARK 200  DATA REDUNDANCY                : 4.100
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : 0.05800
REMARK 200   FOR THE DATA SET  : 15.6300
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.65
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.70
REMARK 200  COMPLETENESS FOR SHELL     (%) : 99.9
REMARK 200  DATA REDUNDANCY IN SHELL       : 4.20
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : 0.37700
REMARK 200   FOR SHELL         : 3.590
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHENIX
REMARK 200 STARTING MODEL: CHAIN A OF PDB ENTRY 3KD2
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 46.99
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.32
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 14% PEG 8000, 0.125M CALCIUM CHLORIDE,
REMARK 280  0.1M SODIUM ACETATE, 0.02M 1,2-HEXANEDIOL, VAPOR DIFFUSION,
REMARK 280  HANGING DROP, TEMPERATURE 291K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 1 2 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y,-Z
REMARK 290       3555   X+1/2,Y+1/2,Z
REMARK 290       4555   -X+1/2,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   3  1.000000  0.000000  0.000000       84.88400
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       42.12450
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000       84.88400
REMARK 290   SMTRY2   4  0.000000  1.000000  0.000000       42.12450
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 2760 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 20610 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -24.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 2780 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 20630 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -23.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 375
REMARK 375 SPECIAL POSITION
REMARK 375 THE FOLLOWING ATOMS ARE FOUND TO BE WITHIN 0.15 ANGSTROMS
REMARK 375 OF A SYMMETRY RELATED ATOM AND ARE ASSUMED TO BE ON SPECIAL
REMARK 375 POSITIONS.
REMARK 375
REMARK 375 ATOM RES CSSEQI
REMARK 375      HOH D 589  LIES ON A SPECIAL POSITION.
REMARK 375      HOH A 712  LIES ON A SPECIAL POSITION.
REMARK 375      HOH C 635  LIES ON A SPECIAL POSITION.
REMARK 375      HOH C 646  LIES ON A SPECIAL POSITION.
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     GLY A   318
REMARK 465     ARG A   319
REMARK 465     HIS A   320
REMARK 465     HIS A   321
REMARK 465     HIS A   322
REMARK 465     HIS A   323
REMARK 465     HIS A   324
REMARK 465     HIS A   325
REMARK 465     GLY B   318
REMARK 465     ARG B   319
REMARK 465     HIS B   320
REMARK 465     HIS B   321
REMARK 465     HIS B   322
REMARK 465     HIS B   323
REMARK 465     HIS B   324
REMARK 465     HIS B   325
REMARK 465     GLY C   318
REMARK 465     ARG C   319
REMARK 465     HIS C   320
REMARK 465     HIS C   321
REMARK 465     HIS C   322
REMARK 465     HIS C   323
REMARK 465     HIS C   324
REMARK 465     HIS C   325
REMARK 465     GLY D   318
REMARK 465     ARG D   319
REMARK 465     HIS D   320
REMARK 465     HIS D   321
REMARK 465     HIS D   322
REMARK 465     HIS D   323
REMARK 465     HIS D   324
REMARK 465     HIS D   325
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ASP A 129     -132.27     60.70
REMARK 500    CYS A 303       54.87   -144.11
REMARK 500    THR B  99      -69.67    -93.04
REMARK 500    ASP B 129     -132.64     60.13
REMARK 500    ALA B 154      148.25   -175.96
REMARK 500    ASP B 185       19.57     55.54
REMARK 500    ASP C 129     -131.30     60.24
REMARK 500    CYS C 303       56.01   -143.33
REMARK 500    THR D  99      -67.69    -93.07
REMARK 500    ASP D 129     -133.49     59.39
REMARK 500    ALA D 154      148.41   -176.69
REMARK 500    CYS D 303       55.94   -144.01
REMARK 500
REMARK 500 REMARK: NULL
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE 0RE B 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE 0RE D 401
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 3KD2   RELATED DB: PDB
REMARK 900 SAME PROTEIN, BUT THE APO-STRUCTURE
REMARK 900 RELATED ID: 3KDA   RELATED DB: PDB
REMARK 900 RELATED ID: 3PI6   RELATED DB: PDB
REMARK 900 RELATED ID: 4DLN   RELATED DB: PDB
REMARK 900 RELATED ID: 4DM7   RELATED DB: PDB
REMARK 900 RELATED ID: 4DMC   RELATED DB: PDB
REMARK 900 RELATED ID: 4DMF   RELATED DB: PDB
REMARK 900 RELATED ID: 4DMH   RELATED DB: PDB
REMARK 900 RELATED ID: 4DNF   RELATED DB: PDB
REMARK 900 RELATED ID: 4DNO   RELATED DB: PDB
DBREF  4EUS A   25   319  UNP    Q02P97   Q02P97_PSEAB    25    319
DBREF  4EUS B   25   319  UNP    Q02P97   Q02P97_PSEAB    25    319
DBREF  4EUS C   25   319  UNP    Q02P97   Q02P97_PSEAB    25    319
DBREF  4EUS D   25   319  UNP    Q02P97   Q02P97_PSEAB    25    319
SEQADV 4EUS HIS A  320  UNP  Q02P97              EXPRESSION TAG
SEQADV 4EUS HIS A  321  UNP  Q02P97              EXPRESSION TAG
SEQADV 4EUS HIS A  322  UNP  Q02P97              EXPRESSION TAG
SEQADV 4EUS HIS A  323  UNP  Q02P97              EXPRESSION TAG
SEQADV 4EUS HIS A  324  UNP  Q02P97              EXPRESSION TAG
SEQADV 4EUS HIS A  325  UNP  Q02P97              EXPRESSION TAG
SEQADV 4EUS HIS B  320  UNP  Q02P97              EXPRESSION TAG
SEQADV 4EUS HIS B  321  UNP  Q02P97              EXPRESSION TAG
SEQADV 4EUS HIS B  322  UNP  Q02P97              EXPRESSION TAG
SEQADV 4EUS HIS B  323  UNP  Q02P97              EXPRESSION TAG
SEQADV 4EUS HIS B  324  UNP  Q02P97              EXPRESSION TAG
SEQADV 4EUS HIS B  325  UNP  Q02P97              EXPRESSION TAG
SEQADV 4EUS HIS C  320  UNP  Q02P97              EXPRESSION TAG
SEQADV 4EUS HIS C  321  UNP  Q02P97              EXPRESSION TAG
SEQADV 4EUS HIS C  322  UNP  Q02P97              EXPRESSION TAG
SEQADV 4EUS HIS C  323  UNP  Q02P97              EXPRESSION TAG
SEQADV 4EUS HIS C  324  UNP  Q02P97              EXPRESSION TAG
SEQADV 4EUS HIS C  325  UNP  Q02P97              EXPRESSION TAG
SEQADV 4EUS HIS D  320  UNP  Q02P97              EXPRESSION TAG
SEQADV 4EUS HIS D  321  UNP  Q02P97              EXPRESSION TAG
SEQADV 4EUS HIS D  322  UNP  Q02P97              EXPRESSION TAG
SEQADV 4EUS HIS D  323  UNP  Q02P97              EXPRESSION TAG
SEQADV 4EUS HIS D  324  UNP  Q02P97              EXPRESSION TAG
SEQADV 4EUS HIS D  325  UNP  Q02P97              EXPRESSION TAG
SEQRES   1 A  301  ALA GLU GLU PHE PRO VAL PRO ASN GLY PHE GLU SER ALA
SEQRES   2 A  301  TYR ARG GLU VAL ASP GLY VAL LYS LEU HIS TYR VAL LYS
SEQRES   3 A  301  GLY GLY GLN GLY PRO LEU VAL MET LEU VAL HIS GLY PHE
SEQRES   4 A  301  GLY GLN THR TRP TYR GLU TRP HIS GLN LEU MET PRO GLU
SEQRES   5 A  301  LEU ALA LYS ARG PHE THR VAL ILE ALA PRO ASP LEU PRO
SEQRES   6 A  301  GLY LEU GLY GLN SER GLU PRO PRO LYS THR GLY TYR SER
SEQRES   7 A  301  GLY GLU GLN VAL ALA VAL TYR LEU HIS LYS LEU ALA ARG
SEQRES   8 A  301  GLN PHE SER PRO ASP ARG PRO PHE ASP LEU VAL ALA HIS
SEQRES   9 A  301  ASP ILE GLY ILE TRP ASN THR TYR PRO MET VAL VAL LYS
SEQRES  10 A  301  ASN GLN ALA ASP ILE ALA ARG LEU VAL TYR MET GLU ALA
SEQRES  11 A  301  PRO ILE PRO ASP ALA ARG ILE TYR ARG PHE PRO ALA PHE
SEQRES  12 A  301  THR ALA GLN GLY GLU SER LEU VAL TRP HIS PHE SER PHE
SEQRES  13 A  301  PHE ALA ALA ASP ASP ARG LEU ALA GLU THR LEU ILE ALA
SEQRES  14 A  301  GLY LYS GLU ARG PHE PHE LEU GLU HIS PHE ILE LYS SER
SEQRES  15 A  301  HIS ALA SER ASN THR GLU VAL PHE SER GLU ARG LEU LEU
SEQRES  16 A  301  ASP LEU TYR ALA ARG SER TYR ALA LYS PRO HIS SER LEU
SEQRES  17 A  301  ASN ALA SER PHE GLU TYR TYR ARG ALA LEU ASN GLU SER
SEQRES  18 A  301  VAL ARG GLN ASN ALA GLU LEU ALA LYS THR ARG LEU GLN
SEQRES  19 A  301  MET PRO THR MET THR LEU ALA GLY GLY GLY HIS GLY GLY
SEQRES  20 A  301  MET GLY THR PHE GLN LEU GLU GLN MET LYS ALA TYR ALA
SEQRES  21 A  301  GLU ASP VAL GLU GLY HIS VAL LEU PRO GLY CYS GLY HIS
SEQRES  22 A  301  TRP LEU PRO GLU GLU CYS ALA ALA PRO MET ASN ARG LEU
SEQRES  23 A  301  VAL ILE ASP PHE LEU SER ARG GLY ARG HIS HIS HIS HIS
SEQRES  24 A  301  HIS HIS
SEQRES   1 B  301  ALA GLU GLU PHE PRO VAL PRO ASN GLY PHE GLU SER ALA
SEQRES   2 B  301  TYR ARG GLU VAL ASP GLY VAL LYS LEU HIS TYR VAL LYS
SEQRES   3 B  301  GLY GLY GLN GLY PRO LEU VAL MET LEU VAL HIS GLY PHE
SEQRES   4 B  301  GLY GLN THR TRP TYR GLU TRP HIS GLN LEU MET PRO GLU
SEQRES   5 B  301  LEU ALA LYS ARG PHE THR VAL ILE ALA PRO ASP LEU PRO
SEQRES   6 B  301  GLY LEU GLY GLN SER GLU PRO PRO LYS THR GLY TYR SER
SEQRES   7 B  301  GLY GLU GLN VAL ALA VAL TYR LEU HIS LYS LEU ALA ARG
SEQRES   8 B  301  GLN PHE SER PRO ASP ARG PRO PHE ASP LEU VAL ALA HIS
SEQRES   9 B  301  ASP ILE GLY ILE TRP ASN THR TYR PRO MET VAL VAL LYS
SEQRES  10 B  301  ASN GLN ALA ASP ILE ALA ARG LEU VAL TYR MET GLU ALA
SEQRES  11 B  301  PRO ILE PRO ASP ALA ARG ILE TYR ARG PHE PRO ALA PHE
SEQRES  12 B  301  THR ALA GLN GLY GLU SER LEU VAL TRP HIS PHE SER PHE
SEQRES  13 B  301  PHE ALA ALA ASP ASP ARG LEU ALA GLU THR LEU ILE ALA
SEQRES  14 B  301  GLY LYS GLU ARG PHE PHE LEU GLU HIS PHE ILE LYS SER
SEQRES  15 B  301  HIS ALA SER ASN THR GLU VAL PHE SER GLU ARG LEU LEU
SEQRES  16 B  301  ASP LEU TYR ALA ARG SER TYR ALA LYS PRO HIS SER LEU
SEQRES  17 B  301  ASN ALA SER PHE GLU TYR TYR ARG ALA LEU ASN GLU SER
SEQRES  18 B  301  VAL ARG GLN ASN ALA GLU LEU ALA LYS THR ARG LEU GLN
SEQRES  19 B  301  MET PRO THR MET THR LEU ALA GLY GLY GLY HIS GLY GLY
SEQRES  20 B  301  MET GLY THR PHE GLN LEU GLU GLN MET LYS ALA TYR ALA
SEQRES  21 B  301  GLU ASP VAL GLU GLY HIS VAL LEU PRO GLY CYS GLY HIS
SEQRES  22 B  301  TRP LEU PRO GLU GLU CYS ALA ALA PRO MET ASN ARG LEU
SEQRES  23 B  301  VAL ILE ASP PHE LEU SER ARG GLY ARG HIS HIS HIS HIS
SEQRES  24 B  301  HIS HIS
SEQRES   1 C  301  ALA GLU GLU PHE PRO VAL PRO ASN GLY PHE GLU SER ALA
SEQRES   2 C  301  TYR ARG GLU VAL ASP GLY VAL LYS LEU HIS TYR VAL LYS
SEQRES   3 C  301  GLY GLY GLN GLY PRO LEU VAL MET LEU VAL HIS GLY PHE
SEQRES   4 C  301  GLY GLN THR TRP TYR GLU TRP HIS GLN LEU MET PRO GLU
SEQRES   5 C  301  LEU ALA LYS ARG PHE THR VAL ILE ALA PRO ASP LEU PRO
SEQRES   6 C  301  GLY LEU GLY GLN SER GLU PRO PRO LYS THR GLY TYR SER
SEQRES   7 C  301  GLY GLU GLN VAL ALA VAL TYR LEU HIS LYS LEU ALA ARG
SEQRES   8 C  301  GLN PHE SER PRO ASP ARG PRO PHE ASP LEU VAL ALA HIS
SEQRES   9 C  301  ASP ILE GLY ILE TRP ASN THR TYR PRO MET VAL VAL LYS
SEQRES  10 C  301  ASN GLN ALA ASP ILE ALA ARG LEU VAL TYR MET GLU ALA
SEQRES  11 C  301  PRO ILE PRO ASP ALA ARG ILE TYR ARG PHE PRO ALA PHE
SEQRES  12 C  301  THR ALA GLN GLY GLU SER LEU VAL TRP HIS PHE SER PHE
SEQRES  13 C  301  PHE ALA ALA ASP ASP ARG LEU ALA GLU THR LEU ILE ALA
SEQRES  14 C  301  GLY LYS GLU ARG PHE PHE LEU GLU HIS PHE ILE LYS SER
SEQRES  15 C  301  HIS ALA SER ASN THR GLU VAL PHE SER GLU ARG LEU LEU
SEQRES  16 C  301  ASP LEU TYR ALA ARG SER TYR ALA LYS PRO HIS SER LEU
SEQRES  17 C  301  ASN ALA SER PHE GLU TYR TYR ARG ALA LEU ASN GLU SER
SEQRES  18 C  301  VAL ARG GLN ASN ALA GLU LEU ALA LYS THR ARG LEU GLN
SEQRES  19 C  301  MET PRO THR MET THR LEU ALA GLY GLY GLY HIS GLY GLY
SEQRES  20 C  301  MET GLY THR PHE GLN LEU GLU GLN MET LYS ALA TYR ALA
SEQRES  21 C  301  GLU ASP VAL GLU GLY HIS VAL LEU PRO GLY CYS GLY HIS
SEQRES  22 C  301  TRP LEU PRO GLU GLU CYS ALA ALA PRO MET ASN ARG LEU
SEQRES  23 C  301  VAL ILE ASP PHE LEU SER ARG GLY ARG HIS HIS HIS HIS
SEQRES  24 C  301  HIS HIS
SEQRES   1 D  301  ALA GLU GLU PHE PRO VAL PRO ASN GLY PHE GLU SER ALA
SEQRES   2 D  301  TYR ARG GLU VAL ASP GLY VAL LYS LEU HIS TYR VAL LYS
SEQRES   3 D  301  GLY GLY GLN GLY PRO LEU VAL MET LEU VAL HIS GLY PHE
SEQRES   4 D  301  GLY GLN THR TRP TYR GLU TRP HIS GLN LEU MET PRO GLU
SEQRES   5 D  301  LEU ALA LYS ARG PHE THR VAL ILE ALA PRO ASP LEU PRO
SEQRES   6 D  301  GLY LEU GLY GLN SER GLU PRO PRO LYS THR GLY TYR SER
SEQRES   7 D  301  GLY GLU GLN VAL ALA VAL TYR LEU HIS LYS LEU ALA ARG
SEQRES   8 D  301  GLN PHE SER PRO ASP ARG PRO PHE ASP LEU VAL ALA HIS
SEQRES   9 D  301  ASP ILE GLY ILE TRP ASN THR TYR PRO MET VAL VAL LYS
SEQRES  10 D  301  ASN GLN ALA ASP ILE ALA ARG LEU VAL TYR MET GLU ALA
SEQRES  11 D  301  PRO ILE PRO ASP ALA ARG ILE TYR ARG PHE PRO ALA PHE
SEQRES  12 D  301  THR ALA GLN GLY GLU SER LEU VAL TRP HIS PHE SER PHE
SEQRES  13 D  301  PHE ALA ALA ASP ASP ARG LEU ALA GLU THR LEU ILE ALA
SEQRES  14 D  301  GLY LYS GLU ARG PHE PHE LEU GLU HIS PHE ILE LYS SER
SEQRES  15 D  301  HIS ALA SER ASN THR GLU VAL PHE SER GLU ARG LEU LEU
SEQRES  16 D  301  ASP LEU TYR ALA ARG SER TYR ALA LYS PRO HIS SER LEU
SEQRES  17 D  301  ASN ALA SER PHE GLU TYR TYR ARG ALA LEU ASN GLU SER
SEQRES  18 D  301  VAL ARG GLN ASN ALA GLU LEU ALA LYS THR ARG LEU GLN
SEQRES  19 D  301  MET PRO THR MET THR LEU ALA GLY GLY GLY HIS GLY GLY
SEQRES  20 D  301  MET GLY THR PHE GLN LEU GLU GLN MET LYS ALA TYR ALA
SEQRES  21 D  301  GLU ASP VAL GLU GLY HIS VAL LEU PRO GLY CYS GLY HIS
SEQRES  22 D  301  TRP LEU PRO GLU GLU CYS ALA ALA PRO MET ASN ARG LEU
SEQRES  23 D  301  VAL ILE ASP PHE LEU SER ARG GLY ARG HIS HIS HIS HIS
SEQRES  24 D  301  HIS HIS
HET    0RE  B 401       8
HET    0RE  D 401       8
HETNAM     0RE (2S)-HEXANE-1,2-DIOL
FORMUL   5  0RE    2(C6 H14 O2)
FORMUL   7  HOH   *1334(H2 O)
HELIX    1   1 THR A   66  HIS A   71  5                                   6
HELIX    2   2 LEU A   73  ALA A   78  1                                   6
HELIX    3   3 SER A  102  SER A  118  1                                  17
HELIX    4   4 ASP A  129  ASN A  134  1                                   6
HELIX    5   5 THR A  135  ASN A  142  1                                   8
HELIX    6   6 ASP A  158  PHE A  164  5                                   7
HELIX    7   7 TRP A  176  ALA A  183  1                                   8
HELIX    8   8 ARG A  186  ALA A  193  1                                   8
HELIX    9   9 LYS A  195  HIS A  207  1                                  13
HELIX   10  10 ASN A  210  PHE A  214  5                                   5
HELIX   11  11 SER A  215  ALA A  227  1                                  13
HELIX   12  12 LYS A  228  ALA A  241  1                                  14
HELIX   13  13 ALA A  241  ALA A  253  1                                  13
HELIX   14  14 THR A  274  ALA A  284  1                                  11
HELIX   15  15 TRP A  298  CYS A  303  1                                   6
HELIX   16  16 CYS A  303  SER A  316  1                                  14
HELIX   17  17 THR B   66  HIS B   71  5                                   6
HELIX   18  18 GLN B   72  ALA B   78  1                                   7
HELIX   19  19 SER B  102  SER B  118  1                                  17
HELIX   20  20 ASP B  129  ASN B  134  1                                   6
HELIX   21  21 THR B  135  ASN B  142  1                                   8
HELIX   22  22 ASP B  158  PHE B  164  5                                   7
HELIX   23  23 TRP B  176  ALA B  183  1                                   8
HELIX   24  24 ARG B  186  ALA B  193  1                                   8
HELIX   25  25 LYS B  195  HIS B  207  1                                  13
HELIX   26  26 ASN B  210  PHE B  214  5                                   5
HELIX   27  27 SER B  215  ALA B  227  1                                  13
HELIX   28  28 LYS B  228  ALA B  241  1                                  14
HELIX   29  29 ALA B  241  ALA B  253  1                                  13
HELIX   30  30 THR B  274  LYS B  281  1                                   8
HELIX   31  31 TRP B  298  CYS B  303  1                                   6
HELIX   32  32 CYS B  303  ARG B  317  1                                  15
HELIX   33  33 THR C   66  HIS C   71  5                                   6
HELIX   34  34 LEU C   73  ALA C   78  1                                   6
HELIX   35  35 SER C  102  SER C  118  1                                  17
HELIX   36  36 ASP C  129  ASN C  134  1                                   6
HELIX   37  37 THR C  135  ASN C  142  1                                   8
HELIX   38  38 ASP C  158  PHE C  164  5                                   7
HELIX   39  39 TRP C  176  ALA C  183  1                                   8
HELIX   40  40 ARG C  186  ALA C  193  1                                   8
HELIX   41  41 LYS C  195  HIS C  207  1                                  13
HELIX   42  42 ASN C  210  PHE C  214  5                                   5
HELIX   43  43 SER C  215  ALA C  227  1                                  13
HELIX   44  44 LYS C  228  ALA C  241  1                                  14
HELIX   45  45 ALA C  241  ALA C  253  1                                  13
HELIX   46  46 THR C  274  LYS C  281  1                                   8
HELIX   47  47 TRP C  298  CYS C  303  1                                   6
HELIX   48  48 CYS C  303  SER C  316  1                                  14
HELIX   49  49 THR D   66  HIS D   71  5                                   6
HELIX   50  50 GLN D   72  ALA D   78  1                                   7
HELIX   51  51 SER D  102  SER D  118  1                                  17
HELIX   52  52 ASP D  129  ASN D  134  1                                   6
HELIX   53  53 THR D  135  ASN D  142  1                                   8
HELIX   54  54 ASP D  158  PHE D  164  5                                   7
HELIX   55  55 TRP D  176  ALA D  183  1                                   8
HELIX   56  56 ARG D  186  ALA D  193  1                                   8
HELIX   57  57 LYS D  195  HIS D  207  1                                  13
HELIX   58  58 ASN D  210  PHE D  214  5                                   5
HELIX   59  59 SER D  215  ALA D  227  1                                  13
HELIX   60  60 LYS D  228  ALA D  241  1                                  14
HELIX   61  61 ALA D  241  ALA D  253  1                                  13
HELIX   62  62 THR D  274  LYS D  281  1                                   8
HELIX   63  63 TRP D  298  CYS D  303  1                                   6
HELIX   64  64 CYS D  303  SER D  316  1                                  14
SHEET    1   A 8 GLU A  35  VAL A  41  0
SHEET    2   A 8 VAL A  44  GLY A  52 -1  O  VAL A  44   N  VAL A  41
SHEET    3   A 8 THR A  82  PRO A  86 -1  O  VAL A  83   N  GLY A  51
SHEET    4   A 8 LEU A  56  VAL A  60  1  N  LEU A  59   O  ILE A  84
SHEET    5   A 8 PHE A 123  HIS A 128  1  O  ASP A 124   N  LEU A  56
SHEET    6   A 8 ILE A 146  MET A 152  1  O  VAL A 150   N  LEU A 125
SHEET    7   A 8 THR A 261  GLY A 266  1  O  MET A 262   N  TYR A 151
SHEET    8   A 8 VAL A 287  LEU A 292  1  O  LEU A 292   N  ALA A 265
SHEET    1   B 2 PHE A 167  THR A 168  0
SHEET    2   B 2 GLY A 171  GLU A 172 -1  O  GLY A 171   N  THR A 168
SHEET    1   C 8 PHE B  34  VAL B  41  0
SHEET    2   C 8 VAL B  44  GLY B  52 -1  O  LEU B  46   N  ARG B  39
SHEET    3   C 8 THR B  82  PRO B  86 -1  O  VAL B  83   N  GLY B  51
SHEET    4   C 8 LEU B  56  VAL B  60  1  N  VAL B  57   O  ILE B  84
SHEET    5   C 8 PHE B 123  HIS B 128  1  O  VAL B 126   N  VAL B  60
SHEET    6   C 8 ILE B 146  MET B 152  1  O  VAL B 150   N  LEU B 125
SHEET    7   C 8 THR B 261  GLY B 266  1  O  MET B 262   N  LEU B 149
SHEET    8   C 8 VAL B 287  LEU B 292  1  O  LEU B 292   N  ALA B 265
SHEET    1   D 2 PHE B 167  THR B 168  0
SHEET    2   D 2 GLY B 171  GLU B 172 -1  O  GLY B 171   N  THR B 168
SHEET    1   E 8 GLU C  35  VAL C  41  0
SHEET    2   E 8 VAL C  44  GLY C  52 -1  O  LEU C  46   N  ARG C  39
SHEET    3   E 8 THR C  82  PRO C  86 -1  O  VAL C  83   N  GLY C  51
SHEET    4   E 8 LEU C  56  VAL C  60  1  N  LEU C  59   O  ILE C  84
SHEET    5   E 8 PHE C 123  HIS C 128  1  O  VAL C 126   N  VAL C  60
SHEET    6   E 8 ILE C 146  MET C 152  1  O  VAL C 150   N  LEU C 125
SHEET    7   E 8 THR C 261  GLY C 266  1  O  MET C 262   N  TYR C 151
SHEET    8   E 8 VAL C 287  LEU C 292  1  O  LEU C 292   N  ALA C 265
SHEET    1   F 2 PHE C 167  THR C 168  0
SHEET    2   F 2 GLY C 171  GLU C 172 -1  O  GLY C 171   N  THR C 168
SHEET    1   G 8 PHE D  34  VAL D  41  0
SHEET    2   G 8 VAL D  44  GLY D  52 -1  O  LEU D  46   N  ARG D  39
SHEET    3   G 8 THR D  82  PRO D  86 -1  O  VAL D  83   N  GLY D  51
SHEET    4   G 8 LEU D  56  VAL D  60  1  N  VAL D  57   O  THR D  82
SHEET    5   G 8 PHE D 123  HIS D 128  1  O  VAL D 126   N  VAL D  60
SHEET    6   G 8 ILE D 146  MET D 152  1  O  VAL D 150   N  LEU D 125
SHEET    7   G 8 THR D 261  GLY D 266  1  O  MET D 262   N  LEU D 149
SHEET    8   G 8 VAL D 287  LEU D 292  1  O  LEU D 292   N  ALA D 265
SHEET    1   H 2 PHE D 167  THR D 168  0
SHEET    2   H 2 GLY D 171  GLU D 172 -1  O  GLY D 171   N  THR D 168
SSBOND   1 CYS A  295    CYS A  303                          1555   1555  2.01
SSBOND   2 CYS B  295    CYS B  303                          1555   1555  2.01
SSBOND   3 CYS C  295    CYS C  303                          1555   1555  2.01
SSBOND   4 CYS D  295    CYS D  303                          1555   1555  2.00
SITE     1 AC1 13 ASP B 129  ILE B 130  TRP B 133  GLU B 153
SITE     2 AC1 13 PRO B 155  HIS B 177  PHE B 178  TYR B 239
SITE     3 AC1 13 MET B 272  HIS B 297  HOH B 579  HOH B 629
SITE     4 AC1 13 HOH B 685
SITE     1 AC2 10 ASP D 129  TRP D 133  PRO D 155  HIS D 177
SITE     2 AC2 10 PHE D 178  TYR D 239  MET D 272  HIS D 297
SITE     3 AC2 10 HOH D 538  HOH D 664
CRYST1  169.768   84.249   90.132  90.00 100.31  90.00 C 1 2 1      16
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.005890  0.000000  0.001071        0.00000
SCALE2      0.000000  0.011870  0.000000        0.00000
SCALE3      0.000000  0.000000  0.011277        0.00000
TER    2392      ARG A 317
TER    4735      ARG B 317
TER    7128      ARG C 317
TER    9467      ARG D 317
MASTER      396    0    2   64   40    0    7    610702    4   24   96
END