longtext: 4FKB-pdb

content
HEADER    HYDROLASE                               13-JUN-12   4FKB
TITLE     AN ORGANIC SOLVENT TOLERANT LIPASE 42
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: THERMOSTABLE ORGANIC SOLVENT TOLERANT LIPASE;
COMPND   3 CHAIN: A, B;
COMPND   4 EC: 3.1.1.3;
COMPND   5 ENGINEERED: YES;
COMPND   6 MUTATION: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: BACILLUS SP. 42;
SOURCE   3 ORGANISM_TAXID: 294830;
SOURCE   4 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   5 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    A/B CANNONICAL FOLD, HYDROLASE, CLEAVE LIPID
EXPDTA    X-RAY DIFFRACTION
AUTHOR    R.N.ZALIHA,R.A.RAHMAN,M.S.KHUSAINI
REVDAT   1   19-JUN-13 4FKB    0
JRNL        AUTH   R.N.ZALIHA,R.N.RAHMAN,M.S.KHUSAINI
JRNL        TITL   AN ORGANIC SOLVENT TOLERANT LIPASE 42
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    1.22 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.6.0117
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.22
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 50.00
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL
REMARK   3   COMPLETENESS FOR RANGE        (%) : 93.7
REMARK   3   NUMBER OF REFLECTIONS             : 244769
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.129
REMARK   3   R VALUE            (WORKING SET) : 0.127
REMARK   3   FREE R VALUE                     : 0.165
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000
REMARK   3   FREE R VALUE TEST SET COUNT      : 12959
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 1.22
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 1.25
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 16466
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 86.16
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2620
REMARK   3   BIN FREE R VALUE SET COUNT          : 891
REMARK   3   BIN FREE R VALUE                    : 0.3020
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 6102
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 143
REMARK   3   SOLVENT ATOMS            : 1015
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 15.09
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : 0.19000
REMARK   3    B22 (A**2) : -0.17000
REMARK   3    B33 (A**2) : -0.00000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.06000
REMARK   3    B23 (A**2) : -0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.034
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.037
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.025
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 1.300
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.981
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.970
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  6797 ; 0.025 ; 0.020
REMARK   3   BOND LENGTHS OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES):  9291 ; 2.308 ; 1.952
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):   889 ; 5.912 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   337 ;33.283 ;22.967
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  1058 ;12.487 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    59 ;16.315 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):   993 ; 0.172 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  5350 ; 0.016 ; 0.021
REMARK   3   GENERAL PLANES OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  4040 ; 2.650 ; 1.500
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  6550 ; 3.567 ; 2.000
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  2757 ; 5.325 ; 3.000
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  2687 ; 7.411 ; 4.500
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  6796 ; 9.943 ; 3.000
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):   287 ;47.343 ; 5.000
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  7340 ;14.173 ; 5.000
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN USED IF PRESENT IN
REMARK   3  THE INPUT
REMARK   4
REMARK   4 4FKB COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 14-JUN-12.
REMARK 100 THE RCSB ID CODE IS RCSB073005.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 07-FEB-11
REMARK 200  TEMPERATURE           (KELVIN) : 200
REMARK 200  PH                             : 8
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SPRING-8
REMARK 200  BEAMLINE                       : BL41XU
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.75
REMARK 200  MONOCHROMATOR                  : ROTATED-INCLINED DOUBLE-CRYSTAL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : MARMOSAIC 225 MM CCD
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 275120
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.220
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 93.7
REMARK 200  DATA REDUNDANCY                : NULL
REMARK 200  R MERGE                    (I) : 0.05600
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : NULL
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.22
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.25
REMARK 200  COMPLETENESS FOR SHELL     (%) : 93.7
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: SHELXS
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 54.85
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.72
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: COUNTER-DIFFUSION METHOD WITHOUT
REMARK 280  MIXING THE PROTEIN AND PRECIPITANT, PH 8, LIQUID DIFFUSION,
REMARK 280  TEMPERATURE 293.15K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 1 2 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y,-Z
REMARK 290       3555   X+1/2,Y+1/2,Z
REMARK 290       4555   -X+1/2,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   3  1.000000  0.000000  0.000000       58.91200
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       40.50050
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000       58.91200
REMARK 290   SMTRY2   4  0.000000  1.000000  0.000000       40.50050
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 375
REMARK 375 SPECIAL POSITION
REMARK 375 THE FOLLOWING ATOMS ARE FOUND TO BE WITHIN 0.15 ANGSTROMS
REMARK 375 OF A SYMMETRY RELATED ATOM AND ARE ASSUMED TO BE ON SPECIAL
REMARK 375 POSITIONS.
REMARK 375
REMARK 375 ATOM RES CSSEQI
REMARK 375 CL    CL A 416  LIES ON A SPECIAL POSITION.
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     ALA A     1
REMARK 465     ALA B     1
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     GLN A 216    CG   CD   OE1  NE2
REMARK 470     GLU B 381    CG   CD   OE1  OE2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   O1   GOL A   402     C1   GOL A   411              1.45
REMARK 500   O    HOH B   537     O    HOH B   717              1.73
REMARK 500   O    HOH B   717     O    HOH B   935              1.74
REMARK 500   O    HOH A   682     O    HOH A   968              1.77
REMARK 500   O    HOH B   668     O    HOH B   909              1.79
REMARK 500   OG   SER A   201     O2   GOL A   411              1.81
REMARK 500   NH1  ARG A   378     O    HOH A  1010              1.81
REMARK 500   CE2  PHE A    16     O    HOH A   710              1.83
REMARK 500   OE2  GLU B   149     O    HOH B   938              1.85
REMARK 500   OE1  GLN B   131     O    HOH B   977              1.95
REMARK 500   NE2  GLN A   254     O    HOH A   935              1.96
REMARK 500   O3   GOL B   407     O    HOH B   916              1.97
REMARK 500   O    HOH B   799     O    HOH B   981              1.97
REMARK 500   CG2  THR A   306     O    HOH A   683              1.99
REMARK 500   O    HOH B   631     O    HOH B   824              2.05
REMARK 500   O    HOH A   686     O    HOH A   990              2.06
REMARK 500   O    HOH A   915     O    HOH A  1019              2.08
REMARK 500   O    HOH A   655     O    HOH A  1015              2.08
REMARK 500   O1   GOL B   410     O    HOH B   780              2.09
REMARK 500   O    HOH B   811     O    HOH B   987              2.09
REMARK 500   OE1  GLU A   250     O    HOH A   947              2.11
REMARK 500   O    HOH A   713     O    HOH A   965              2.12
REMARK 500   O    HOH A   996     O    HOH A  1022              2.12
REMARK 500   O    HOH A   778     O    HOH A  1014              2.13
REMARK 500   O    HOH A   702     O    HOH A   896              2.14
REMARK 500   O    HOH A   761     O    HOH A  1000              2.14
REMARK 500   O    HOH A   728     O    HOH A   995              2.16
REMARK 500   O    HOH B   970     O    HOH B   971              2.17
REMARK 500   OG   SER B   201     O    HOH B   702              2.17
REMARK 500   CZ   PHE A    16     O    HOH A   710              2.17
REMARK 500   O    HOH A   757     O    HOH A   987              2.17
REMARK 500   O    HOH A   732     O    HOH A   849              2.18
REMARK 500   O    HOH B   907     O    HOH B   984              2.19
REMARK 500   O    HOH B   729     O    HOH B   796              2.19
REMARK 500   NH2  ARG B   214     O    HOH B   749              2.19
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS
REMARK 500
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.
REMARK 500
REMARK 500 DISTANCE CUTOFF:
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE
REMARK 500   O    HOH A   683     O    HOH B   718     4545     2.03
REMARK 500   O    HOH B   736     O    HOH B   761     4545     2.09
REMARK 500   O    HOH A   684     O    HOH B   682     3445     2.16
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION
REMARK 500    TRP A  40   CE2   TRP A  40   CD2     0.083
REMARK 500    GLU A 100   CD    GLU A 100   OE1     0.094
REMARK 500    ARG A 303   CZ    ARG A 303   NH1     0.138
REMARK 500    ARG A 303   CZ    ARG A 303   NH2     0.109
REMARK 500    GLU B 202   CB    GLU B 202   CG     -0.130
REMARK 500    GLU B 202   CD    GLU B 202   OE2     0.110
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    ARG A  21   NE  -  CZ  -  NH1 ANGL. DEV. =   3.5 DEGREES
REMARK 500    ARG A  62   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.5 DEGREES
REMARK 500    ARG A  89   NE  -  CZ  -  NH1 ANGL. DEV. =  -3.5 DEGREES
REMARK 500    ARG A 230   NE  -  CZ  -  NH1 ANGL. DEV. =   5.4 DEGREES
REMARK 500    ARG A 230   NE  -  CZ  -  NH2 ANGL. DEV. =  -4.3 DEGREES
REMARK 500    LEU A 277   CB  -  CG  -  CD2 ANGL. DEV. = -10.3 DEGREES
REMARK 500    GLY A 279   C   -  N   -  CA  ANGL. DEV. = -17.3 DEGREES
REMARK 500    ARG A 330   NE  -  CZ  -  NH1 ANGL. DEV. =  -5.3 DEGREES
REMARK 500    ARG A 330   NE  -  CZ  -  NH2 ANGL. DEV. =   3.1 DEGREES
REMARK 500    TYR A 354   CB  -  CG  -  CD2 ANGL. DEV. =  -4.1 DEGREES
REMARK 500    ASP A 357   CB  -  CG  -  OD1 ANGL. DEV. =   6.8 DEGREES
REMARK 500    ARG A 378   NE  -  CZ  -  NH1 ANGL. DEV. =   3.9 DEGREES
REMARK 500    LEU B   3   CA  -  CB  -  CG  ANGL. DEV. = -17.5 DEGREES
REMARK 500    ARG B  47   NE  -  CZ  -  NH2 ANGL. DEV. =  -5.7 DEGREES
REMARK 500    ARG B  92   NE  -  CZ  -  NH2 ANGL. DEV. =  -4.2 DEGREES
REMARK 500    ARG B 103   NE  -  CZ  -  NH1 ANGL. DEV. =   3.3 DEGREES
REMARK 500    ARG B 103   NE  -  CZ  -  NH2 ANGL. DEV. =  -4.2 DEGREES
REMARK 500    ARG B 106   NE  -  CZ  -  NH1 ANGL. DEV. =  -5.6 DEGREES
REMARK 500    ARG B 214   NE  -  CZ  -  NH1 ANGL. DEV. =   3.7 DEGREES
REMARK 500    ARG B 214   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.3 DEGREES
REMARK 500    ARG B 271   NE  -  CZ  -  NH2 ANGL. DEV. =  -4.1 DEGREES
REMARK 500    ARG B 303   NE  -  CZ  -  NH2 ANGL. DEV. =   4.1 DEGREES
REMARK 500    ARG B 330   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.3 DEGREES
REMARK 500    ASP B 357   CB  -  CG  -  OD1 ANGL. DEV. =   8.1 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    SER A 113     -136.14     56.69
REMARK 500    VAL A 203      -59.17     70.18
REMARK 500    LEU A 208       37.29    -99.42
REMARK 500    ARG A 271       44.15   -147.18
REMARK 500    LEU A 277      -71.73    -87.71
REMARK 500    ASP A 310     -155.77   -130.29
REMARK 500    ILE A 319      -41.32   -138.89
REMARK 500    LYS A 329      -46.40   -133.66
REMARK 500    ASN A 367       90.21   -164.99
REMARK 500    SER B 113     -138.16     59.87
REMARK 500    ASP B 175       37.39    -95.03
REMARK 500    VAL B 203      -55.82     72.17
REMARK 500    LEU B 208       35.31    -99.57
REMARK 500    ARG B 271       45.74   -152.67
REMARK 500    LEU B 277      -66.62    -93.31
REMARK 500    ASN B 304       82.83   -151.11
REMARK 500    ASP B 310     -158.54   -127.55
REMARK 500    ILE B 319      -36.14   -137.35
REMARK 500    LYS B 329      -51.73   -133.22
REMARK 500    ASN B 367       91.64   -169.91
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500                                 MODEL     OMEGA
REMARK 500 PHE A   16     THR A   17                  149.20
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CHIRAL CENTERS
REMARK 500
REMARK 500 UNEXPECTED CONFIGURATION OF THE FOLLOWING CHIRAL
REMARK 500 CENTER(S) USING IMPROPER CA--C--CB--N CHIRALITY
REMARK 500 FOR AMINO ACIDS AND C1'--O4'--N1(N9)--C2' FOR
REMARK 500 NUCLEIC ACIDS OR EQUIVALENT ANGLE
REMARK 500 M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,6X,F5.1,6X,A1,10X,A1,3X,A16)
REMARK 500
REMARK 500  M RES CSSEQI    IMPROPER   EXPECTED   FOUND DETAILS
REMARK 500    VAL A 294        21.1      L          L   OUTSIDE RANGE
REMARK 500
REMARK 500 REMARK: NULL
REMARK 610
REMARK 610 MISSING HETEROATOM
REMARK 610 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 610 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 610 I=INSERTION CODE):
REMARK 610   M RES C SSEQI
REMARK 610     GOL A  402
REMARK 610     GOL A  411
REMARK 620
REMARK 620 METAL COORDINATION
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              ZN B 401  ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ASP B 238   OD2
REMARK 620 2 ASP B  61   OD1 124.8
REMARK 620 3 HIS B  87   NE2  97.6 120.2
REMARK 620 4 HIS B  81   NE2 107.4  98.7 106.8
REMARK 620 N                    1     2     3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              NA A 407  NA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 GLU A 202   OE1
REMARK 620 2 GLU A 202   OE2  41.6
REMARK 620 N                    1
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              ZN A 401  ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ASP A 238   OD2
REMARK 620 2 ASP A  61   OD1 129.4
REMARK 620 3 HIS A  81   NE2 107.8  98.4
REMARK 620 4 HIS A  87   NE2  96.6 116.0 107.3
REMARK 620 N                    1     2     3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              NA A 404  NA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 HOH A 693   O
REMARK 620 2 LYS A 329   O    94.1
REMARK 620 3 HOH A 766   O   178.0  87.9
REMARK 620 4 SER A 332   O    90.3  95.3  89.9
REMARK 620 5 HOH A 861   O    55.9 146.9 122.2  73.4
REMARK 620 6 HOH A 826   O    95.7  76.4  84.5 170.1 116.5
REMARK 620 N                    1     2     3     4     5
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              NA B 403  NA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 HOH B 910   O
REMARK 620 2 HOH B 575   O    76.9
REMARK 620 3 SER B 369   OG  108.9  84.3
REMARK 620 4 HOH B 724   O   100.0  91.1 148.8
REMARK 620 N                    1     2     3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              NA A 406  NA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 HOH A 742   O
REMARK 620 2 HOH A 743   O   172.5
REMARK 620 3 HOH A 760   O    85.4  92.6
REMARK 620 4 HOH A 578   O    83.5  89.1  83.4
REMARK 620 5 HOH A 967   O    76.3 110.6  81.0 155.3
REMARK 620 N                    1     2     3     4
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              NA A 405  NA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 HOH A 578   O
REMARK 620 2 THR A 272   O   170.7
REMARK 620 3 HOH A 760   O    91.5  89.6
REMARK 620 4 GLU A 270   OE1  91.4  92.9 145.5
REMARK 620 5 GLU A 284   OE2  76.2  94.6 104.1 109.9
REMARK 620 6 HOH A 577   O   126.3  62.9  75.8  74.8 157.4
REMARK 620 7 HOH A 684   O    89.7  83.9  50.4 163.9  54.9 116.9
REMARK 620 N                    1     2     3     4     5     6
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              NA B 402  NA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 HOH B 816   O
REMARK 620 2 HOH B 730   O    80.8
REMARK 620 3 LYS B 329   O   165.3  93.9
REMARK 620 4 HOH B 757   O    93.5 172.1  92.9
REMARK 620 5 SER B 332   O    71.5  91.1  95.0  92.3
REMARK 620 N                    1     2     3     4
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              NA B 404  NA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 THR B 272   O
REMARK 620 2 HOH B 726   O   150.0
REMARK 620 3 GLU B 270   OE1  96.2  90.4
REMARK 620 4 HOH B 621   O    69.0 140.8  76.7
REMARK 620 5 HOH B 653   O    79.9  83.0 157.6 121.1
REMARK 620 6 HOH B 900   O   135.7  71.2  99.2  74.6  98.8
REMARK 620 7 GLU B 284   OE2  85.1  64.9 102.3 153.7  55.6 130.7
REMARK 620 N                    1     2     3     4     5     6
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              NA B 405  NA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 HOH B 918   O
REMARK 620 2 HOH B 929   O    87.5
REMARK 620 3 HOH A 884   O   171.4  98.3
REMARK 620 4 HOH A 727   O    94.2 161.1  78.3
REMARK 620 5 HOH B 746   O    89.9  79.8  85.0  81.4
REMARK 620 N                    1     2     3     4
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA B 424  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 GLU B 360   OE2
REMARK 620 2 GLY B 286   O    85.1
REMARK 620 3 HOH B 660   O   147.7  86.9
REMARK 620 4 PRO B 366   O    91.9 165.3  88.0
REMARK 620 5 ASP B 365   OD2 111.5 104.2 100.8  90.3
REMARK 620 6 HOH B 691   O    91.6  88.3  56.9  77.3 154.3
REMARK 620 N                    1     2     3     4     5
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA A 420  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 HOH A 666   O
REMARK 620 2 PRO A 366   O    89.1
REMARK 620 3 GLY A 286   O    87.8 165.0
REMARK 620 4 GLU A 360   OE2 145.6  90.3  83.9
REMARK 620 5 ASP A 365   OD2 101.3  91.8 103.2 113.0
REMARK 620 6 HOH A 747   O    57.6  80.5  85.5  88.4 157.4
REMARK 620 N                    1     2     3     4     5
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              NA B 406  NA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 HOH B 733   O
REMARK 620 2 HOH B 519   O   113.8
REMARK 620 3 ALA B 192   O    78.0  88.3
REMARK 620 4 HOH B 543   O    72.0 162.4  76.5
REMARK 620 N                    1     2     3
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN A 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL A 402
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL A 403
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NA A 404
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NA A 405
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NA A 406
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NA A 407
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL A 408
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL A 409
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL A 410
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL A 411
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL A 412
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL A 413
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL A 414
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL A 415
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL A 416
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL A 417
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL A 418
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL A 419
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA A 420
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN B 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NA B 402
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NA B 403
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NA B 404
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NA B 405
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NA B 406
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 407
REMARK 800
REMARK 800 SITE_IDENTIFIER: DC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 408
REMARK 800
REMARK 800 SITE_IDENTIFIER: DC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 409
REMARK 800
REMARK 800 SITE_IDENTIFIER: DC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 410
REMARK 800
REMARK 800 SITE_IDENTIFIER: DC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 411
REMARK 800
REMARK 800 SITE_IDENTIFIER: DC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 412
REMARK 800
REMARK 800 SITE_IDENTIFIER: DC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 413
REMARK 800
REMARK 800 SITE_IDENTIFIER: DC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 414
REMARK 800
REMARK 800 SITE_IDENTIFIER: DC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 415
REMARK 800
REMARK 800 SITE_IDENTIFIER: DC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 416
REMARK 800
REMARK 800 SITE_IDENTIFIER: EC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 417
REMARK 800
REMARK 800 SITE_IDENTIFIER: EC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 418
REMARK 800
REMARK 800 SITE_IDENTIFIER: EC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 419
REMARK 800
REMARK 800 SITE_IDENTIFIER: EC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 420
REMARK 800
REMARK 800 SITE_IDENTIFIER: EC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 421
REMARK 800
REMARK 800 SITE_IDENTIFIER: EC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 422
REMARK 800
REMARK 800 SITE_IDENTIFIER: EC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 423
REMARK 800
REMARK 800 SITE_IDENTIFIER: EC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA B 424
DBREF  4FKB A    1   388  UNP    Q5U780   Q5U780_9BACI    29    416
DBREF  4FKB B    1   388  UNP    Q5U780   Q5U780_9BACI    29    416
SEQADV 4FKB LEU A  147  UNP  Q5U780    TRP   175 ENGINEERED MUTATION
SEQADV 4FKB GLU A  202  UNP  Q5U780    GLN   230 ENGINEERED MUTATION
SEQADV 4FKB LEU B  147  UNP  Q5U780    TRP   175 ENGINEERED MUTATION
SEQADV 4FKB GLU B  202  UNP  Q5U780    GLN   230 ENGINEERED MUTATION
SEQRES   1 A  388  ALA SER LEU ARG ALA ASN ASP ALA PRO ILE VAL LEU LEU
SEQRES   2 A  388  HIS GLY PHE THR GLY TRP GLY ARG GLU GLU MET PHE GLY
SEQRES   3 A  388  PHE LYS TYR TRP GLY GLY VAL ARG GLY ASP ILE GLU GLN
SEQRES   4 A  388  TRP LEU ASN ASP ASN GLY TYR ARG THR TYR THR LEU ALA
SEQRES   5 A  388  VAL GLY PRO LEU SER SER ASN TRP ASP ARG ALA CYS GLU
SEQRES   6 A  388  ALA TYR ALA GLN LEU VAL GLY GLY THR VAL ASP TYR GLY
SEQRES   7 A  388  ALA ALA HIS ALA ALA LYS HIS GLY HIS ALA ARG PHE GLY
SEQRES   8 A  388  ARG THR TYR PRO GLY LEU LEU PRO GLU LEU LYS ARG GLY
SEQRES   9 A  388  GLY ARG ILE HIS ILE ILE ALA HIS SER GLN GLY GLY GLN
SEQRES  10 A  388  THR ALA ARG MET LEU VAL SER LEU LEU GLU ASN GLY SER
SEQRES  11 A  388  GLN GLU GLU ARG GLU TYR ALA LYS ALA HIS ASN VAL SER
SEQRES  12 A  388  LEU SER PRO LEU PHE GLU GLY GLY HIS HIS PHE VAL LEU
SEQRES  13 A  388  SER VAL THR THR ILE ALA THR PRO HIS ASP GLY THR THR
SEQRES  14 A  388  LEU VAL ASN MET VAL ASP PHE THR ASP ARG PHE PHE ASP
SEQRES  15 A  388  LEU GLN LYS ALA VAL LEU GLU ALA ALA ALA VAL ALA SER
SEQRES  16 A  388  ASN VAL PRO TYR THR SER GLU VAL TYR ASP PHE LYS LEU
SEQRES  17 A  388  ASP GLN TRP GLY LEU ARG ARG GLN PRO GLY GLU SER PHE
SEQRES  18 A  388  ASP HIS TYR PHE GLU ARG LEU LYS ARG SER PRO VAL TRP
SEQRES  19 A  388  THR SER THR ASP THR ALA ARG TYR ASP LEU SER VAL SER
SEQRES  20 A  388  GLY ALA GLU LYS LEU ASN GLN TRP VAL GLN ALA SER PRO
SEQRES  21 A  388  ASN THR TYR TYR LEU SER PHE SER THR GLU ARG THR TYR
SEQRES  22 A  388  ARG GLY ALA LEU THR GLY ASN HIS TYR PRO GLU LEU GLY
SEQRES  23 A  388  MET ASN ALA PHE SER ALA VAL VAL CYS ALA PRO PHE LEU
SEQRES  24 A  388  GLY SER TYR ARG ASN PRO THR LEU GLY ILE ASP ASP ARG
SEQRES  25 A  388  TRP LEU GLU ASN ASP GLY ILE VAL ASN THR VAL SER MET
SEQRES  26 A  388  ASN GLY PRO LYS ARG GLY SER SER ASP ARG ILE VAL PRO
SEQRES  27 A  388  TYR ASP GLY THR LEU LYS LYS GLY VAL TRP ASN ASP MET
SEQRES  28 A  388  GLY THR TYR ASN VAL ASP HIS LEU GLU ILE ILE GLY VAL
SEQRES  29 A  388  ASP PRO ASN PRO SER PHE ASP ILE ARG ALA PHE TYR LEU
SEQRES  30 A  388  ARG LEU ALA GLU GLN LEU ALA SER LEU ARG PRO
SEQRES   1 B  388  ALA SER LEU ARG ALA ASN ASP ALA PRO ILE VAL LEU LEU
SEQRES   2 B  388  HIS GLY PHE THR GLY TRP GLY ARG GLU GLU MET PHE GLY
SEQRES   3 B  388  PHE LYS TYR TRP GLY GLY VAL ARG GLY ASP ILE GLU GLN
SEQRES   4 B  388  TRP LEU ASN ASP ASN GLY TYR ARG THR TYR THR LEU ALA
SEQRES   5 B  388  VAL GLY PRO LEU SER SER ASN TRP ASP ARG ALA CYS GLU
SEQRES   6 B  388  ALA TYR ALA GLN LEU VAL GLY GLY THR VAL ASP TYR GLY
SEQRES   7 B  388  ALA ALA HIS ALA ALA LYS HIS GLY HIS ALA ARG PHE GLY
SEQRES   8 B  388  ARG THR TYR PRO GLY LEU LEU PRO GLU LEU LYS ARG GLY
SEQRES   9 B  388  GLY ARG ILE HIS ILE ILE ALA HIS SER GLN GLY GLY GLN
SEQRES  10 B  388  THR ALA ARG MET LEU VAL SER LEU LEU GLU ASN GLY SER
SEQRES  11 B  388  GLN GLU GLU ARG GLU TYR ALA LYS ALA HIS ASN VAL SER
SEQRES  12 B  388  LEU SER PRO LEU PHE GLU GLY GLY HIS HIS PHE VAL LEU
SEQRES  13 B  388  SER VAL THR THR ILE ALA THR PRO HIS ASP GLY THR THR
SEQRES  14 B  388  LEU VAL ASN MET VAL ASP PHE THR ASP ARG PHE PHE ASP
SEQRES  15 B  388  LEU GLN LYS ALA VAL LEU GLU ALA ALA ALA VAL ALA SER
SEQRES  16 B  388  ASN VAL PRO TYR THR SER GLU VAL TYR ASP PHE LYS LEU
SEQRES  17 B  388  ASP GLN TRP GLY LEU ARG ARG GLN PRO GLY GLU SER PHE
SEQRES  18 B  388  ASP HIS TYR PHE GLU ARG LEU LYS ARG SER PRO VAL TRP
SEQRES  19 B  388  THR SER THR ASP THR ALA ARG TYR ASP LEU SER VAL SER
SEQRES  20 B  388  GLY ALA GLU LYS LEU ASN GLN TRP VAL GLN ALA SER PRO
SEQRES  21 B  388  ASN THR TYR TYR LEU SER PHE SER THR GLU ARG THR TYR
SEQRES  22 B  388  ARG GLY ALA LEU THR GLY ASN HIS TYR PRO GLU LEU GLY
SEQRES  23 B  388  MET ASN ALA PHE SER ALA VAL VAL CYS ALA PRO PHE LEU
SEQRES  24 B  388  GLY SER TYR ARG ASN PRO THR LEU GLY ILE ASP ASP ARG
SEQRES  25 B  388  TRP LEU GLU ASN ASP GLY ILE VAL ASN THR VAL SER MET
SEQRES  26 B  388  ASN GLY PRO LYS ARG GLY SER SER ASP ARG ILE VAL PRO
SEQRES  27 B  388  TYR ASP GLY THR LEU LYS LYS GLY VAL TRP ASN ASP MET
SEQRES  28 B  388  GLY THR TYR ASN VAL ASP HIS LEU GLU ILE ILE GLY VAL
SEQRES  29 B  388  ASP PRO ASN PRO SER PHE ASP ILE ARG ALA PHE TYR LEU
SEQRES  30 B  388  ARG LEU ALA GLU GLN LEU ALA SER LEU ARG PRO
HET     ZN  A 401       1
HET    GOL  A 402       1
HET    GOL  A 403      12
HET     NA  A 404       1
HET     NA  A 405       1
HET     NA  A 406       1
HET     NA  A 407       1
HET    GOL  A 408       6
HET    GOL  A 409       6
HET    GOL  A 410       6
HET    GOL  A 411       5
HET    GOL  A 412       6
HET    GOL  A 413       6
HET    GOL  A 414       6
HET     CL  A 415       1
HET     CL  A 416       1
HET     CL  A 417       1
HET     CL  A 418       1
HET     CL  A 419       1
HET     CA  A 420       1
HET     ZN  B 401       1
HET     NA  B 402       1
HET     NA  B 403       1
HET     NA  B 404       1
HET     NA  B 405       1
HET     NA  B 406       1
HET    GOL  B 407       6
HET    GOL  B 408      18
HET    GOL  B 409       6
HET    GOL  B 410       6
HET    GOL  B 411       6
HET    GOL  B 412       6
HET    GOL  B 413      12
HET    GOL  B 414       6
HET    GOL  B 415       6
HET    GOL  B 416       6
HET    GOL  B 417       6
HET    GOL  B 418       6
HET     CL  B 419       1
HET     CL  B 420       1
HET     CL  B 421       1
HET     CL  B 422       1
HET     CL  B 423       1
HET     CA  B 424       1
HETNAM      ZN ZINC ION
HETNAM     GOL GLYCEROL
HETNAM      NA SODIUM ION
HETNAM      CL CHLORIDE ION
HETNAM      CA CALCIUM ION
HETSYN     GOL GLYCERIN; PROPANE-1,2,3-TRIOL
FORMUL   3   ZN    2(ZN 2+)
FORMUL   4  GOL    21(C3 H8 O3)
FORMUL   6   NA    9(NA 1+)
FORMUL  17   CL    10(CL 1-)
FORMUL  22   CA    2(CA 2+)
FORMUL  47  HOH   *1015(H2 O)
HELIX    1   1 GLU A   23  PHE A   27  5                                   5
HELIX    2   2 GLY A   31  GLY A   35  5                                   5
HELIX    3   3 ASP A   36  ASN A   44  1                                   9
HELIX    4   4 SER A   58  GLY A   72  1                                  15
HELIX    5   5 GLY A   78  GLY A   86  1                                   9
HELIX    6   6 LEU A   98  ARG A  103  5                                   6
HELIX    7   7 GLN A  114  GLY A  129  1                                  16
HELIX    8   8 SER A  130  ASN A  141  1                                  12
HELIX    9   9 SER A  145  GLU A  149  5                                   5
HELIX   10  10 THR A  168  MET A  173  5                                   6
HELIX   11  11 ASP A  175  ALA A  191  1                                  17
HELIX   12  12 LEU A  208  GLY A  212  5                                   5
HELIX   13  13 SER A  220  ARG A  230  1                                  11
HELIX   14  14 SER A  231  SER A  236  1                                   6
HELIX   15  15 THR A  239  SER A  245  1                                   7
HELIX   16  16 SER A  245  VAL A  256  1                                  12
HELIX   17  17 ASN A  288  CYS A  295  1                                   8
HELIX   18  18 CYS A  295  GLY A  300  1                                   6
HELIX   19  19 ASN A  304  GLY A  308  5                                   5
HELIX   20  20 ASP A  310  LEU A  314  5                                   5
HELIX   21  21 ASN A  321  ASN A  326  5                                   6
HELIX   22  22 ASP A  371  SER A  385  1                                  15
HELIX   23  23 GLU B   23  PHE B   27  5                                   5
HELIX   24  24 GLY B   31  GLY B   35  5                                   5
HELIX   25  25 ASP B   36  ASN B   44  1                                   9
HELIX   26  26 SER B   58  GLY B   72  1                                  15
HELIX   27  27 GLY B   78  GLY B   86  1                                   9
HELIX   28  28 LEU B   98  GLY B  104  5                                   7
HELIX   29  29 GLN B  114  GLY B  129  1                                  16
HELIX   30  30 SER B  130  ASN B  141  1                                  12
HELIX   31  31 SER B  145  GLU B  149  5                                   5
HELIX   32  32 THR B  168  MET B  173  5                                   6
HELIX   33  33 ASP B  175  ALA B  191  1                                  17
HELIX   34  34 LEU B  208  GLY B  212  5                                   5
HELIX   35  35 SER B  220  ARG B  230  1                                  11
HELIX   36  36 SER B  231  SER B  236  1                                   6
HELIX   37  37 THR B  239  SER B  245  1                                   7
HELIX   38  38 SER B  245  VAL B  256  1                                  12
HELIX   39  39 ASN B  288  CYS B  295  1                                   8
HELIX   40  40 CYS B  295  GLY B  300  1                                   6
HELIX   41  41 ASN B  304  GLY B  308  5                                   5
HELIX   42  42 ASP B  310  LEU B  314  5                                   5
HELIX   43  43 ASN B  321  MET B  325  5                                   5
HELIX   44  44 ASP B  371  SER B  385  1                                  15
SHEET    1   A 7 THR A  48  THR A  50  0
SHEET    2   A 7 ILE A  10  LEU A  13  1  N  LEU A  12   O  TYR A  49
SHEET    3   A 7 ILE A 107  HIS A 112  1  O  HIS A 108   N  VAL A  11
SHEET    4   A 7 VAL A 155  ILE A 161  1  O  THR A 159   N  ILE A 109
SHEET    5   A 7 TYR A 263  THR A 269  1  O  TYR A 263   N  LEU A 156
SHEET    6   A 7 TRP A 348  TYR A 354  1  O  ASN A 349   N  TYR A 264
SHEET    7   A 7 ILE A 336  PRO A 338  1  N  VAL A 337   O  TRP A 348
SHEET    1   B 2 GLY A  73  ASP A  76  0
SHEET    2   B 2 PHE A  90  TYR A  94 -1  O  TYR A  94   N  GLY A  73
SHEET    1   C 2 THR A 272  ARG A 274  0
SHEET    2   C 2 HIS A 281  PRO A 283 -1  O  TYR A 282   N  TYR A 273
SHEET    1   D 7 THR B  48  THR B  50  0
SHEET    2   D 7 ILE B  10  LEU B  13  1  N  LEU B  12   O  TYR B  49
SHEET    3   D 7 ILE B 107  HIS B 112  1  O  HIS B 108   N  VAL B  11
SHEET    4   D 7 VAL B 155  ILE B 161  1  O  THR B 159   N  ALA B 111
SHEET    5   D 7 TYR B 263  THR B 269  1  O  LEU B 265   N  VAL B 158
SHEET    6   D 7 TRP B 348  TYR B 354  1  O  MET B 351   N  SER B 266
SHEET    7   D 7 ILE B 336  PRO B 338  1  N  VAL B 337   O  TRP B 348
SHEET    1   E 2 GLY B  73  ASP B  76  0
SHEET    2   E 2 PHE B  90  TYR B  94 -1  O  ARG B  92   N  VAL B  75
SHEET    1   F 2 THR B 272  ARG B 274  0
SHEET    2   F 2 HIS B 281  PRO B 283 -1  O  TYR B 282   N  TYR B 273
LINK         OD2 ASP B 238                ZN    ZN B 401     1555   1555  1.96
LINK         OE1 GLU A 202                NA    NA A 407     1555   1555  1.97
LINK         OD1 ASP B  61                ZN    ZN B 401     1555   1555  1.98
LINK         OD2 ASP A 238                ZN    ZN A 401     1555   1555  1.99
LINK         NE2 HIS B  87                ZN    ZN B 401     1555   1555  2.00
LINK         OD1 ASP A  61                ZN    ZN A 401     1555   1555  2.00
LINK         NE2 HIS A  81                ZN    ZN A 401     1555   1555  2.00
LINK         NE2 HIS A  87                ZN    ZN A 401     1555   1555  2.01
LINK        NA    NA A 404                 O   HOH A 693     1555   1555  2.02
LINK         NE2 HIS B  81                ZN    ZN B 401     1555   1555  2.03
LINK        NA    NA B 403                 O   HOH B 910     1555   1555  2.07
LINK        NA    NA A 406                 O   HOH A 742     1555   1555  2.11
LINK        NA    NA A 405                 O   HOH A 578     1555   1555  2.12
LINK        NA    NA B 402                 O   HOH B 816     1555   1555  2.12
LINK        NA    NA B 402                 O   HOH B 730     1555   1555  2.13
LINK         O   THR B 272                NA    NA B 404     1555   1555  2.16
LINK        NA    NA B 404                 O   HOH B 726     1555   1555  2.17
LINK         O   THR A 272                NA    NA A 405     1555   1555  2.19
LINK        NA    NA A 406                 O   HOH A 743     1555   1555  2.22
LINK        NA    NA B 405                 O   HOH B 918     1555   1555  2.23
LINK        NA    NA A 405                 O   HOH A 760     1555   1555  2.29
LINK         OE2 GLU B 360                CA    CA B 424     1555   1555  2.29
LINK         O   LYS B 329                NA    NA B 402     1555   1555  2.31
LINK         O   GLY B 286                CA    CA B 424     1555   1555  2.31
LINK        CA    CA B 424                 O   HOH B 660     1555   1555  2.31
LINK        CA    CA A 420                 O   HOH A 666     1555   1555  2.31
LINK         O   PRO A 366                CA    CA A 420     1555   1555  2.32
LINK         O   LYS A 329                NA    NA A 404     1555   1555  2.34
LINK         O   GLY A 286                CA    CA A 420     1555   1555  2.34
LINK        NA    NA B 406                 O   HOH B 733     1555   1555  2.35
LINK         O   PRO B 366                CA    CA B 424     1555   1555  2.35
LINK        NA    NA B 406                 O   HOH B 519     1555   1555  2.35
LINK         O   ALA B 192                NA    NA B 406     1555   1555  2.35
LINK         OE2 GLU A 360                CA    CA A 420     1555   1555  2.35
LINK        NA    NA B 405                 O   HOH B 929     1555   1555  2.36
LINK         OD2 ASP A 365                CA    CA A 420     1555   1555  2.36
LINK        NA    NA A 406                 O   HOH A 760     1555   1555  2.37
LINK         OE1 GLU A 270                NA    NA A 405     1555   1555  2.37
LINK        NA    NA B 406                 O   HOH B 543     1555   1555  2.37
LINK        NA    NA A 406                 O   HOH A 578     1555   1555  2.38
LINK        NA    NA B 402                 O   HOH B 757     1555   1555  2.39
LINK         OD2 ASP B 365                CA    CA B 424     1555   1555  2.39
LINK         OE1 GLU B 270                NA    NA B 404     1555   1555  2.39
LINK         O   SER B 332                NA    NA B 402     1555   1555  2.43
LINK        NA    NA B 403                 O   HOH B 575     1555   1555  2.45
LINK        NA    NA A 404                 O   HOH A 766     1555   1555  2.47
LINK        NA    NA B 405                 O   HOH A 884     1555   1555  2.49
LINK         O   SER A 332                NA    NA A 404     1555   1555  2.51
LINK         OG ASER B 369                NA    NA B 403     1555   1555  2.55
LINK        NA    NA B 405                 O   HOH A 727     1555   1555  2.56
LINK        NA    NA B 405                 O   HOH B 746     1555   1555  2.58
LINK        NA    NA B 404                 O   HOH B 621     1555   1555  2.64
LINK        NA    NA B 404                 O   HOH B 653     1555   1555  2.65
LINK        CA    CA B 424                 O   HOH B 691     1555   1555  2.67
LINK        NA    NA A 404                 O   HOH A 861     1555   1555  2.70
LINK        NA    NA B 403                 O   HOH B 724     1555   1555  2.72
LINK         OE2 GLU A 284                NA    NA A 405     1555   1555  2.75
LINK        NA    NA A 406                 O   HOH A 967     1555   1555  2.82
LINK        NA    NA B 404                 O   HOH B 900     1555   1555  2.82
LINK        CA    CA A 420                 O   HOH A 747     1555   1555  2.83
LINK        NA    NA A 404                 O   HOH A 826     1555   1555  2.87
LINK        NA    NA A 405                 O   HOH A 577     1555   1555  3.02
LINK        NA    NA A 405                 O   HOH A 684     1555   1555  3.04
LINK         OE2 GLU B 284                NA    NA B 404     1555   1555  3.10
LINK         OE2 GLU A 202                NA    NA A 407     1555   1555  3.18
SITE     1 AC1  4 ASP A  61  HIS A  81  HIS A  87  ASP A 238
SITE     1 AC2  5 GLU A  22  GLU A  23  MET A  24  PHE A  25
SITE     2 AC2  5 GOL A 411
SITE     1 AC3  8 HOH A 570  HOH A 765  HIS B  85  THR B 237
SITE     2 AC3  8 TYR B 242  LYS B 251  GOL B 411  HOH B 604
SITE     1 AC4  6 LYS A 329  SER A 332  HOH A 693  HOH A 766
SITE     2 AC4  6 HOH A 826  HOH A 861
SITE     1 AC5  8 GLU A 270  THR A 272  GLU A 284   NA A 406
SITE     2 AC5  8 HOH A 577  HOH A 578  HOH A 684  HOH A 760
SITE     1 AC6  6  NA A 405  HOH A 578  HOH A 742  HOH A 743
SITE     2 AC6  6 HOH A 760  HOH A 967
SITE     1 AC7  4 GLU A 202  ARG A 214  ARG A 215   CL A 417
SITE     1 AC8  3 THR A 353  TYR A 354  HOH A 546
SITE     1 AC9  8 TRP A  60  HIS A  81  HIS A  85  HOH A 509
SITE     2 AC9  8 HOH A 514  HOH A 534  HOH A 592  HOH A 779
SITE     1 BC1  7 THR A  50  GLN A  69  LEU A  97  HOH A 579
SITE     2 BC1  7 HOH A 629  HOH A 718  HOH A 816
SITE     1 BC2  7 GLU A  22  PHE A  25  SER A 201  GLU A 202
SITE     2 BC2  7 VAL A 203  GOL A 402  HOH A 585
SITE     1 BC3  5 GLU A 127  GLY A 151  HIS A 152  HIS A 153
SITE     2 BC3  5 ASN A 261
SITE     1 BC4  8 ARG A 303  ASP A 310  ASP A 311  HOH A 507
SITE     2 BC4  8 HOH A 617  HOH A 858  PHE B  90  GLY B  91
SITE     1 BC5  3 PHE A  25  ALA A 192  SER A 201
SITE     1 BC6  6 GLY A 275  LEU A 277  THR A 278  GLY A 279
SITE     2 BC6  6 ASN A 280  TYR A 282
SITE     1 BC7  2 THR A 200  SER A 201
SITE     1 BC8  4 PHE A 206  ARG A 215  TYR A 224   NA A 407
SITE     1 BC9  2 ARG A 214  ARG A 227
SITE     1 CC1  5 ARG A  34  PRO A 366  ASN A 367  PRO A 368
SITE     2 CC1  5 HOH A 875
SITE     1 CC2  6 GLY A 286  GLU A 360  ASP A 365  PRO A 366
SITE     2 CC2  6 HOH A 666  HOH A 747
SITE     1 CC3  4 ASP B  61  HIS B  81  HIS B  87  ASP B 238
SITE     1 CC4  5 LYS B 329  SER B 332  HOH B 730  HOH B 757
SITE     2 CC4  5 HOH B 816
SITE     1 CC5  4 SER B 369  HOH B 575  HOH B 724  HOH B 910
SITE     1 CC6  7 GLU B 270  THR B 272  GLU B 284  HOH B 621
SITE     2 CC6  7 HOH B 653  HOH B 726  HOH B 900
SITE     1 CC7  5 HOH A 727  HOH A 884  HOH B 746  HOH B 918
SITE     2 CC7  5 HOH B 929
SITE     1 CC8  6 HIS B 153  ALA B 192  HOH B 519  HOH B 529
SITE     2 CC8  6 HOH B 543  HOH B 733
SITE     1 CC9  7 THR B  50  GLN B  69  TYR B  94  GOL B 413
SITE     2 CC9  7 HOH B 620  HOH B 646  HOH B 916
SITE     1 DC1 12 GLY B  26  PHE B  27  LYS B  28  GLY B  32
SITE     2 DC1 12 GLY B  35  ASP B  36  GLU B 149  GLY B 150
SITE     3 DC1 12 GLY B 151  HIS B 152  HOH B 776  HOH B 938
SITE     1 DC2  9 TYR B 199  THR B 200  GLU B 202  ARG B 214
SITE     2 DC2  9 ARG B 215  GLN B 216  PRO B 217  HOH B 598
SITE     3 DC2  9 HOH B 868
SITE     1 DC3 10 ASP B   7  ALA B   8  GLY B 105  ARG B 106
SITE     2 DC3 10  CL B 420  HOH B 654  HOH B 756  HOH B 780
SITE     3 DC3 10 HOH B 870  HOH B 936
SITE     1 DC4  9 GOL A 403  HOH A 570  HOH A 765  TRP B  60
SITE     2 DC4  9 HIS B  81  HIS B  85  HOH B 506  HOH B 541
SITE     3 DC4  9 HOH B 584
SITE     1 DC5  7 TYR B  67  LYS B 102  HIS B 152  HOH B 549
SITE     2 DC5  7 HOH B 578  HOH B 643  HOH B 775
SITE     1 DC6 10 ARG B  21  GLU B  38  TYR B  49  THR B  50
SITE     2 DC6 10 LEU B  97  GOL B 407  HOH B 700  HOH B 708
SITE     3 DC6 10 HOH B 762  HOH B 826
SITE     1 DC7  2 THR B 353  HOH B 527
SITE     1 DC8  4 ARG B  34  ARG B 373  HOH B 611  HOH B 808
SITE     1 DC9  7 TRP B  60  SER B 130  GLU B 132  TRP B 255
SITE     2 DC9  7 HOH B 584  HOH B 640  HOH B 932
SITE     1 EC1  6 PHE B 267  TYR B 354  PHE B 375  ARG B 378
SITE     2 EC1  6 GLN B 382  HOH B 915
SITE     1 EC2  9 LYS B 185  GLU B 189  SER B 195  HOH B 571
SITE     2 EC2  9 HOH B 608  HOH B 627  HOH B 841  HOH B 880
SITE     3 EC2  9 HOH B 890
SITE     1 EC3  6 GLY B 275  LEU B 277  THR B 278  GLY B 279
SITE     2 EC3  6 ASN B 280  TYR B 282
SITE     1 EC4  2 ARG B 106  GOL B 410
SITE     1 EC5  4 LEU B 213  ARG B 214  GLN B 216  ARG B 227
SITE     1 EC6  6 ARG B  34  PRO B 366  ASN B 367  PRO B 368
SITE     2 EC6  6 HOH B 648  HOH B 810
SITE     1 EC7  5 LEU B 126  HIS B 153  PHE B 154  VAL B 155
SITE     2 EC7  5 HOH B 725
SITE     1 EC8  6 GLY B 286  GLU B 360  ASP B 365  PRO B 366
SITE     2 EC8  6 HOH B 660  HOH B 691
CRYST1  117.824   81.001   99.529  90.00  96.69  90.00 C 1 2 1       8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.008487  0.000000  0.000996        0.00000
SCALE2      0.000000  0.012346  0.000000        0.00000
SCALE3      0.000000  0.000000  0.010116        0.00000
TER    3155      PRO A 388
TER    6442      PRO B 388
MASTER      771    0   44   44   22    0   81    6 7260    2  227   60
END