longtext: 4KAF-pdb

content
HEADER    HYDROLASE                               22-APR-13   4KAF
TITLE     CRYSTAL STRUCTURE OF HALOALKANE DEHALOGENASE HALOTAG7 AT THE
TITLE    2 RESOLUTION 1.5A, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG)
TITLE    3 TARGET OR151
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: HALOALKANE DEHALOGENASE;
COMPND   3 CHAIN: A, B;
COMPND   4 EC: 3.8.1.5;
COMPND   5 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: RHODOCOCCUS SP.;
SOURCE   3 ORGANISM_TAXID: 1831;
SOURCE   4 GENE: DHAA
KEYWDS    STRUCTURAL GENOMICS, PSI-BIOLOGY, PROTEIN STRUCTURE INITIATIVE,
KEYWDS   2 NORTHEAST STRUCTURAL GENOMICS CONSORTIUM, NESG, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    A.P.KUZIN,S.LEW,T.K.NEKLESA,D.NOBLIN,J.SEETHARAMAN,M.MAGLAQUI,R.XIAO,
AUTHOR   2 E.KOHAN,H.WANG,J.K.EVERETT,T.B.ACTON,G.KORNHABER,G.T.MONTELIONE,
AUTHOR   3 C.CREWS,L.TONG,NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG)
REVDAT   1   05-JUN-13 4KAF    0
JRNL        AUTH   A.P.KUZIN,S.LEW,T.K.NEKLESA,D.NOBLIN,J.SEETHARAMAN,
JRNL        AUTH 2 M.MAGLAQUI,R.XIAO,E.KOHAN,H.WANG,J.K.EVERETT,T.B.ACTON,
JRNL        AUTH 3 G.KORNHABER,G.T.MONTELIONE,C.CREWS,L.TONG
JRNL        TITL   NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET OR151
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    1.50 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX (PHENIX.REFINE: DEV_1269)
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VICENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-
REMARK   3               : KUNSTLEVE,LI-WEI HUNG,ROBERT IMMORMINO,
REMARK   3               : TOM IOERGER,AIRLIE MCCOY,ERIK MCKEE,NIGEL
REMARK   3               : MORIARTY,REETAL PAI,RANDY READ,JANE
REMARK   3               : RICHARDSON,DAVID RICHARDSON,TOD ROMO,JIM
REMARK   3               : SACCHETTINI,NICHOLAS SAUTER,JACOB SMITH,
REMARK   3               : LAURENT STORONI,TOM TERWILLIGER,PETER
REMARK   3               : ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : ML
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.50
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 44.40
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.340
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.9
REMARK   3   NUMBER OF REFLECTIONS             : 203210
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.149
REMARK   3   R VALUE            (WORKING SET) : 0.148
REMARK   3   FREE R VALUE                     : 0.165
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 1.900
REMARK   3   FREE R VALUE TEST SET COUNT      : 3857
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 44.4186 -  4.5412    0.99     7136   146  0.1806 0.1895
REMARK   3     2  4.5412 -  3.6050    1.00     7197   137  0.1424 0.1772
REMARK   3     3  3.6050 -  3.1494    1.00     7190   133  0.1498 0.1902
REMARK   3     4  3.1494 -  2.8615    1.00     7197   140  0.1526 0.1505
REMARK   3     5  2.8615 -  2.6565    1.00     7183   147  0.1439 0.1391
REMARK   3     6  2.6565 -  2.4999    1.00     7208   136  0.1441 0.1668
REMARK   3     7  2.4999 -  2.3747    1.00     7182   136  0.1364 0.1458
REMARK   3     8  2.3747 -  2.2713    1.00     7227   142  0.1370 0.1526
REMARK   3     9  2.2713 -  2.1839    1.00     7207   145  0.1413 0.1665
REMARK   3    10  2.1839 -  2.1085    1.00     7168   128  0.1406 0.1549
REMARK   3    11  2.1085 -  2.0426    1.00     7205   151  0.1410 0.1850
REMARK   3    12  2.0426 -  1.9842    1.00     7173   132  0.1381 0.1476
REMARK   3    13  1.9842 -  1.9320    1.00     7168   154  0.1418 0.1582
REMARK   3    14  1.9320 -  1.8848    1.00     7225   119  0.1383 0.1266
REMARK   3    15  1.8848 -  1.8420    1.00     7172   142  0.1385 0.1659
REMARK   3    16  1.8420 -  1.8028    1.00     7162   147  0.1388 0.1597
REMARK   3    17  1.8028 -  1.7667    1.00     7178   130  0.1392 0.1477
REMARK   3    18  1.7667 -  1.7334    1.00     7199   136  0.1460 0.1686
REMARK   3    19  1.7334 -  1.7024    1.00     7164   139  0.1516 0.1806
REMARK   3    20  1.7024 -  1.6736    0.99     7133   125  0.1482 0.1525
REMARK   3    21  1.6736 -  1.6466    1.00     7151   152  0.1509 0.1692
REMARK   3    22  1.6466 -  1.6212    0.99     7190   137  0.1487 0.1347
REMARK   3    23  1.6212 -  1.5974    0.99     7084   162  0.1520 0.1628
REMARK   3    24  1.5974 -  1.5749    0.99     7148   111  0.1542 0.2037
REMARK   3    25  1.5749 -  1.5536    0.99     7104   126  0.1610 0.1815
REMARK   3    26  1.5536 -  1.5334    0.99     7152   160  0.1684 0.1542
REMARK   3    27  1.5334 -  1.5142    0.95     6875   146  0.1841 0.1917
REMARK   3    28  1.5142 -  1.4960    0.83     5975    98  0.1939 0.2246
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.090
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 14.610
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 9.83
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 13.09
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -0.17100
REMARK   3    B22 (A**2) : 0.20000
REMARK   3    B33 (A**2) : -0.02900
REMARK   3    B12 (A**2) : -0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.009           5035
REMARK   3   ANGLE     :  1.364           6883
REMARK   3   CHIRALITY :  0.079            727
REMARK   3   PLANARITY :  0.008            909
REMARK   3   DIHEDRAL  : 12.134           1858
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 1
REMARK   3   TLS GROUP : 1
REMARK   3    SELECTION: all
REMARK   3    ORIGIN FOR THE GROUP (A):   0.1329 -31.3022  25.4694
REMARK   3    T TENSOR
REMARK   3      T11:   0.0616 T22:   0.0493
REMARK   3      T33:   0.0775 T12:   0.0017
REMARK   3      T13:  -0.0056 T23:  -0.0009
REMARK   3    L TENSOR
REMARK   3      L11:   0.2038 L22:   0.1399
REMARK   3      L33:   0.4888 L12:   0.0192
REMARK   3      L13:  -0.1150 L23:   0.0004
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0096 S12:  -0.0018 S13:  -0.0114
REMARK   3      S21:  -0.0015 S22:   0.0038 S23:   0.0021
REMARK   3      S31:   0.0181 S32:   0.0017 S33:   0.0077
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 4KAF COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 25-APR-13.
REMARK 100 THE RCSB ID CODE IS RCSB079093.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 05-JUN-12
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 6
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : NSLS
REMARK 200  BEAMLINE                       : X4A
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.979
REMARK 200  MONOCHROMATOR                  : SI 111 CHANNEL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 4
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000
REMARK 200  DATA SCALING SOFTWARE          : SCALEPACK
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 203311
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.496
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : -3.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.2
REMARK 200  DATA REDUNDANCY                : 6.800
REMARK 200  R MERGE                    (I) : 0.08400
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 36.6000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : NULL
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : NULL
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: BALBES
REMARK 200 STARTING MODEL: PDB ENTRY 4E46
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 47.07
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.32
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: PROTEIN SOLUTION: 100MM NACL, 5MM DTT,
REMARK 280  0.02% NAN3, 10MM TRIS-HCL (PH 7.5) . RESERVOIR SOLUTION: AMMONIUM
REMARK 280  THIOCYNATE, MES 0.1M, PEG 4000 20%, MICROBATCH UNDER OIL,
REMARK 280  TEMPERATURE 277K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X+1/2,-Y,Z+1/2
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       34.46500
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       50.25100
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       47.40000
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       50.25100
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       34.46500
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       47.40000
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 300 REMARK: MONOMER,35.49 KD,99.1%
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MSE A     1
REMARK 465     GLY A     2
REMARK 465     HIS A     3
REMARK 465     HIS A     4
REMARK 465     HIS A     5
REMARK 465     HIS A     6
REMARK 465     HIS A     7
REMARK 465     HIS A     8
REMARK 465     SER A     9
REMARK 465     HIS A    10
REMARK 465     MSE A    11
REMARK 465     MSE B    -9
REMARK 465     GLY B    -8
REMARK 465     HIS B    -7
REMARK 465     HIS B    -6
REMARK 465     HIS B    -5
REMARK 465     HIS B    -4
REMARK 465     HIS B    -3
REMARK 465     HIS B    -2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   O    PHE B    20     O1   EDO B   405              2.14
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    PRO A  52       45.17   -105.67
REMARK 500    GLU A 108      -95.19   -107.16
REMARK 500    ASP A 116     -134.71     58.18
REMARK 500    ASP A 166      -49.99     72.34
REMARK 500    VAL A 255      -62.93   -131.48
REMARK 500    LEU A 281      -98.92   -116.45
REMARK 500    PRO B  52       46.26   -108.54
REMARK 500    GLU B 108      -93.21   -107.97
REMARK 500    ASP B 116     -135.16     57.50
REMARK 500    ASP B 166      -55.36     73.92
REMARK 500    VAL B 255      -68.30   -127.86
REMARK 500    LEU B 281     -100.12   -119.02
REMARK 500    SER B 306       35.46    117.57
REMARK 500
REMARK 500 REMARK: NULL
REMARK 620
REMARK 620 METAL COORDINATION
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              NA A 402  NA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 GLU A 224   OE2
REMARK 620 2 HOH B 581   O   108.7
REMARK 620 3 HOH A 715   O   105.0 108.8
REMARK 620 4 HOH A 536   O   148.0  76.5 102.7
REMARK 620 N                    1     2     3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              NA B 402  NA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 GLU B 224   OE2
REMARK 620 2 HOH A 592   O   120.8
REMARK 620 3 HOH B 736   O    99.9 113.0
REMARK 620 4 HOH B 540   O   143.4  77.5 100.6
REMARK 620 N                    1     2     3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              NA A 404  NA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ASP A  21   OD2
REMARK 620 2 ASP A  21   OD1  58.3
REMARK 620 3 ASP A  36   O   144.2 149.0
REMARK 620 4 HOH A 523   O    98.5  84.3  72.6
REMARK 620 N                    1     2     3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              NA B 403  NA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 HOH B 590   O
REMARK 620 2 HOH B 792   O   117.9
REMARK 620 N                    1
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              NA A 403  NA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 PRO A 184   O
REMARK 620 2 ARG A 189   O   131.1
REMARK 620 3 VAL A 187   O    67.2  69.7
REMARK 620 N                    1     2
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SCN A 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NA A 402
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NA A 403
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NA A 404
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NA A 405
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SCN B 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NA B 402
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NA B 403
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE EDO B 404
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE EDO B 405
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEG B 406
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 4E46   RELATED DB: PDB
REMARK 900 HOMOLOGY IS 92.49%
REMARK 900 RELATED ID: NESG-OR151   RELATED DB: TARGETTRACK
DBREF  4KAF A    9   303  UNP    P0A3G3   DHAA_RHOSO       2    293
DBREF  4KAF B   -1   303  UNP    P0A3G3   DHAA_RHOSO       2    293
SEQADV 4KAF MSE A    1  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF GLY A    2  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF HIS A    3  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF HIS A    4  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF HIS A    5  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF HIS A    6  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF HIS A    7  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF HIS A    8  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF HIS A   10  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF MSE A   11  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF ALA A   12  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF VAL A   57  UNP  P0A3G3    LEU    47 ENGINEERED MUTATION
SEQADV 4KAF THR A   68  UNP  P0A3G3    SER    58 ENGINEERED MUTATION
SEQADV 4KAF GLY A   88  UNP  P0A3G3    ASP    78 ENGINEERED MUTATION
SEQADV 4KAF PHE A   97  UNP  P0A3G3    TYR    87 ENGINEERED MUTATION
SEQADV 4KAF MSE A   98  UNP  P0A3G3    LEU    88 ENGINEERED MUTATION
SEQADV 4KAF ILE A  133  UNP  P0A3G3    VAL   123 ENGINEERED MUTATION
SEQADV 4KAF PHE A  138  UNP  P0A3G3    CYS   128 ENGINEERED MUTATION
SEQADV 4KAF THR A  165  UNP  P0A3G3    ALA   155 ENGINEERED MUTATION
SEQADV 4KAF LYS A  170  UNP  P0A3G3    GLU   160 ENGINEERED MUTATION
SEQADV 4KAF VAL A  177  UNP  P0A3G3    ALA   167 ENGINEERED MUTATION
SEQADV 4KAF THR A  182  UNP  P0A3G3    ALA   172 ENGINEERED MUTATION
SEQADV 4KAF MSE A  185  UNP  P0A3G3    LYS   175 ENGINEERED MUTATION
SEQADV 4KAF GLY A  186  UNP  P0A3G3    CYS   176 ENGINEERED MUTATION
SEQADV 4KAF ASN A  205  UNP  P0A3G3    LYS   195 ENGINEERED MUTATION
SEQADV 4KAF GLU A  234  UNP  P0A3G3    ALA   224 ENGINEERED MUTATION
SEQADV 4KAF ASP A  237  UNP  P0A3G3    ASN   227 ENGINEERED MUTATION
SEQADV 4KAF LYS A  267  UNP  P0A3G3    GLU   257 ENGINEERED MUTATION
SEQADV 4KAF ALA A  274  UNP  P0A3G3    THR   264 ENGINEERED MUTATION
SEQADV 4KAF ASN A  282  UNP  P0A3G3    HIS   272 ENGINEERED MUTATION
SEQADV 4KAF LEU A  283  UNP  P0A3G3    TYR   273 ENGINEERED MUTATION
SEQADV 4KAF SER A  301  UNP  P0A3G3    PRO   291 ENGINEERED MUTATION
SEQADV 4KAF THR A  302  UNP  P0A3G3    ALA   292 ENGINEERED MUTATION
SEQADV 4KAF GLU A  304  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF ILE A  305  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF SER A  306  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF GLY A  307  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF MSE B   -9  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF GLY B   -8  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF HIS B   -7  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF HIS B   -6  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF HIS B   -5  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF HIS B   -4  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF HIS B   -3  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF HIS B   -2  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF HIS B    0  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF MSE B    1  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF ALA B   12  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF VAL B   57  UNP  P0A3G3    LEU    47 ENGINEERED MUTATION
SEQADV 4KAF THR B   68  UNP  P0A3G3    SER    58 ENGINEERED MUTATION
SEQADV 4KAF GLY B   88  UNP  P0A3G3    ASP    78 ENGINEERED MUTATION
SEQADV 4KAF PHE B   97  UNP  P0A3G3    TYR    87 ENGINEERED MUTATION
SEQADV 4KAF MSE B   98  UNP  P0A3G3    LEU    88 ENGINEERED MUTATION
SEQADV 4KAF ILE B  133  UNP  P0A3G3    VAL   123 ENGINEERED MUTATION
SEQADV 4KAF PHE B  138  UNP  P0A3G3    CYS   128 ENGINEERED MUTATION
SEQADV 4KAF THR B  165  UNP  P0A3G3    ALA   155 ENGINEERED MUTATION
SEQADV 4KAF LYS B  170  UNP  P0A3G3    GLU   160 ENGINEERED MUTATION
SEQADV 4KAF VAL B  177  UNP  P0A3G3    ALA   167 ENGINEERED MUTATION
SEQADV 4KAF THR B  182  UNP  P0A3G3    ALA   172 ENGINEERED MUTATION
SEQADV 4KAF MSE B  185  UNP  P0A3G3    LYS   175 ENGINEERED MUTATION
SEQADV 4KAF GLY B  186  UNP  P0A3G3    CYS   176 ENGINEERED MUTATION
SEQADV 4KAF ASN B  205  UNP  P0A3G3    LYS   195 ENGINEERED MUTATION
SEQADV 4KAF GLU B  234  UNP  P0A3G3    ALA   224 ENGINEERED MUTATION
SEQADV 4KAF ASP B  237  UNP  P0A3G3    ASN   227 ENGINEERED MUTATION
SEQADV 4KAF LYS B  267  UNP  P0A3G3    GLU   257 ENGINEERED MUTATION
SEQADV 4KAF ALA B  274  UNP  P0A3G3    THR   264 ENGINEERED MUTATION
SEQADV 4KAF ASN B  282  UNP  P0A3G3    HIS   272 ENGINEERED MUTATION
SEQADV 4KAF LEU B  283  UNP  P0A3G3    TYR   273 ENGINEERED MUTATION
SEQADV 4KAF SER B  301  UNP  P0A3G3    PRO   291 ENGINEERED MUTATION
SEQADV 4KAF THR B  302  UNP  P0A3G3    ALA   292 ENGINEERED MUTATION
SEQADV 4KAF GLU B  304  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF ILE B  305  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF SER B  306  UNP  P0A3G3              EXPRESSION TAG
SEQADV 4KAF GLY B  307  UNP  P0A3G3              EXPRESSION TAG
SEQRES   1 A  307  MSE GLY HIS HIS HIS HIS HIS HIS SER HIS MSE ALA GLU
SEQRES   2 A  307  ILE GLY THR GLY PHE PRO PHE ASP PRO HIS TYR VAL GLU
SEQRES   3 A  307  VAL LEU GLY GLU ARG MSE HIS TYR VAL ASP VAL GLY PRO
SEQRES   4 A  307  ARG ASP GLY THR PRO VAL LEU PHE LEU HIS GLY ASN PRO
SEQRES   5 A  307  THR SER SER TYR VAL TRP ARG ASN ILE ILE PRO HIS VAL
SEQRES   6 A  307  ALA PRO THR HIS ARG CYS ILE ALA PRO ASP LEU ILE GLY
SEQRES   7 A  307  MSE GLY LYS SER ASP LYS PRO ASP LEU GLY TYR PHE PHE
SEQRES   8 A  307  ASP ASP HIS VAL ARG PHE MSE ASP ALA PHE ILE GLU ALA
SEQRES   9 A  307  LEU GLY LEU GLU GLU VAL VAL LEU VAL ILE HIS ASP TRP
SEQRES  10 A  307  GLY SER ALA LEU GLY PHE HIS TRP ALA LYS ARG ASN PRO
SEQRES  11 A  307  GLU ARG ILE LYS GLY ILE ALA PHE MSE GLU PHE ILE ARG
SEQRES  12 A  307  PRO ILE PRO THR TRP ASP GLU TRP PRO GLU PHE ALA ARG
SEQRES  13 A  307  GLU THR PHE GLN ALA PHE ARG THR THR ASP VAL GLY ARG
SEQRES  14 A  307  LYS LEU ILE ILE ASP GLN ASN VAL PHE ILE GLU GLY THR
SEQRES  15 A  307  LEU PRO MSE GLY VAL VAL ARG PRO LEU THR GLU VAL GLU
SEQRES  16 A  307  MSE ASP HIS TYR ARG GLU PRO PHE LEU ASN PRO VAL ASP
SEQRES  17 A  307  ARG GLU PRO LEU TRP ARG PHE PRO ASN GLU LEU PRO ILE
SEQRES  18 A  307  ALA GLY GLU PRO ALA ASN ILE VAL ALA LEU VAL GLU GLU
SEQRES  19 A  307  TYR MSE ASP TRP LEU HIS GLN SER PRO VAL PRO LYS LEU
SEQRES  20 A  307  LEU PHE TRP GLY THR PRO GLY VAL LEU ILE PRO PRO ALA
SEQRES  21 A  307  GLU ALA ALA ARG LEU ALA LYS SER LEU PRO ASN CYS LYS
SEQRES  22 A  307  ALA VAL ASP ILE GLY PRO GLY LEU ASN LEU LEU GLN GLU
SEQRES  23 A  307  ASP ASN PRO ASP LEU ILE GLY SER GLU ILE ALA ARG TRP
SEQRES  24 A  307  LEU SER THR LEU GLU ILE SER GLY
SEQRES   1 B  307  MSE GLY HIS HIS HIS HIS HIS HIS SER HIS MSE ALA GLU
SEQRES   2 B  307  ILE GLY THR GLY PHE PRO PHE ASP PRO HIS TYR VAL GLU
SEQRES   3 B  307  VAL LEU GLY GLU ARG MSE HIS TYR VAL ASP VAL GLY PRO
SEQRES   4 B  307  ARG ASP GLY THR PRO VAL LEU PHE LEU HIS GLY ASN PRO
SEQRES   5 B  307  THR SER SER TYR VAL TRP ARG ASN ILE ILE PRO HIS VAL
SEQRES   6 B  307  ALA PRO THR HIS ARG CYS ILE ALA PRO ASP LEU ILE GLY
SEQRES   7 B  307  MSE GLY LYS SER ASP LYS PRO ASP LEU GLY TYR PHE PHE
SEQRES   8 B  307  ASP ASP HIS VAL ARG PHE MSE ASP ALA PHE ILE GLU ALA
SEQRES   9 B  307  LEU GLY LEU GLU GLU VAL VAL LEU VAL ILE HIS ASP TRP
SEQRES  10 B  307  GLY SER ALA LEU GLY PHE HIS TRP ALA LYS ARG ASN PRO
SEQRES  11 B  307  GLU ARG ILE LYS GLY ILE ALA PHE MSE GLU PHE ILE ARG
SEQRES  12 B  307  PRO ILE PRO THR TRP ASP GLU TRP PRO GLU PHE ALA ARG
SEQRES  13 B  307  GLU THR PHE GLN ALA PHE ARG THR THR ASP VAL GLY ARG
SEQRES  14 B  307  LYS LEU ILE ILE ASP GLN ASN VAL PHE ILE GLU GLY THR
SEQRES  15 B  307  LEU PRO MSE GLY VAL VAL ARG PRO LEU THR GLU VAL GLU
SEQRES  16 B  307  MSE ASP HIS TYR ARG GLU PRO PHE LEU ASN PRO VAL ASP
SEQRES  17 B  307  ARG GLU PRO LEU TRP ARG PHE PRO ASN GLU LEU PRO ILE
SEQRES  18 B  307  ALA GLY GLU PRO ALA ASN ILE VAL ALA LEU VAL GLU GLU
SEQRES  19 B  307  TYR MSE ASP TRP LEU HIS GLN SER PRO VAL PRO LYS LEU
SEQRES  20 B  307  LEU PHE TRP GLY THR PRO GLY VAL LEU ILE PRO PRO ALA
SEQRES  21 B  307  GLU ALA ALA ARG LEU ALA LYS SER LEU PRO ASN CYS LYS
SEQRES  22 B  307  ALA VAL ASP ILE GLY PRO GLY LEU ASN LEU LEU GLN GLU
SEQRES  23 B  307  ASP ASN PRO ASP LEU ILE GLY SER GLU ILE ALA ARG TRP
SEQRES  24 B  307  LEU SER THR LEU GLU ILE SER GLY
MODRES 4KAF MSE A   32  MET  SELENOMETHIONINE
MODRES 4KAF MSE A   79  MET  SELENOMETHIONINE
MODRES 4KAF MSE A   98  MET  SELENOMETHIONINE
MODRES 4KAF MSE A  139  MET  SELENOMETHIONINE
MODRES 4KAF MSE A  185  MET  SELENOMETHIONINE
MODRES 4KAF MSE A  196  MET  SELENOMETHIONINE
MODRES 4KAF MSE A  236  MET  SELENOMETHIONINE
MODRES 4KAF MSE B    1  MET  SELENOMETHIONINE
MODRES 4KAF MSE B   32  MET  SELENOMETHIONINE
MODRES 4KAF MSE B   79  MET  SELENOMETHIONINE
MODRES 4KAF MSE B   98  MET  SELENOMETHIONINE
MODRES 4KAF MSE B  139  MET  SELENOMETHIONINE
MODRES 4KAF MSE B  185  MET  SELENOMETHIONINE
MODRES 4KAF MSE B  196  MET  SELENOMETHIONINE
MODRES 4KAF MSE B  236  MET  SELENOMETHIONINE
HET    MSE  A  32      17
HET    MSE  A  79      31
HET    MSE  A  98      17
HET    MSE  A 139      17
HET    MSE  A 185      34
HET    MSE  A 196      17
HET    MSE  A 236      17
HET    MSE  B   1      17
HET    MSE  B  32      17
HET    MSE  B  79      34
HET    MSE  B  98      17
HET    MSE  B 139      17
HET    MSE  B 185      17
HET    MSE  B 196      17
HET    MSE  B 236      17
HET    SCN  A 401       3
HET    SCN  B 401       3
HET     NA  A 402       1
HET     NA  A 403       1
HET     NA  A 404       1
HET     NA  A 405       1
HET     NA  B 402       1
HET     NA  B 403       1
HET    EDO  B 404       4
HET    EDO  B 405       4
HET    PEG  B 406      14
HETNAM     MSE SELENOMETHIONINE
HETNAM     SCN THIOCYANATE ION
HETNAM      NA SODIUM ION
HETNAM     EDO 1,2-ETHANEDIOL
HETNAM     PEG DI(HYDROXYETHYL)ETHER
HETSYN     EDO ETHYLENE GLYCOL
FORMUL   1  MSE    15(C5 H11 N O2 SE)
FORMUL   3  SCN    2(C N S 1-)
FORMUL   5   NA    6(NA 1+)
FORMUL  11  EDO    2(C2 H6 O2)
FORMUL  13  PEG    C4 H10 O3
FORMUL  14  HOH   *686(H2 O)
HELIX    1   1 SER A   54  ARG A   59  5                                   6
HELIX    2   2 ILE A   61  ALA A   66  1                                   6
HELIX    3   3 PHE A   90  LEU A  105  1                                  16
HELIX    4   4 ASP A  116  ASN A  129  1                                  14
HELIX    5   5 THR A  147  TRP A  151  5                                   5
HELIX    6   6 PRO A  152  ARG A  163  1                                  12
HELIX    7   7 ASP A  166  ILE A  173  1                                   8
HELIX    8   8 ASN A  176  GLY A  181  1                                   6
HELIX    9   9 LEU A  183  VAL A  187  5                                   5
HELIX   10  10 THR A  192  GLU A  201  1                                  10
HELIX   11  11 PRO A  202  LEU A  204  5                                   3
HELIX   12  12 ASN A  205  ASP A  208  5                                   4
HELIX   13  13 ARG A  209  LEU A  219  1                                  11
HELIX   14  14 PRO A  225  SER A  242  1                                  18
HELIX   15  15 PRO A  258  LEU A  269  1                                  12
HELIX   16  16 LEU A  283  ASN A  288  1                                   6
HELIX   17  17 ASN A  288  SER A  301  1                                  14
HELIX   18  18 SER B   54  ARG B   59  5                                   6
HELIX   19  19 ILE B   61  ALA B   66  1                                   6
HELIX   20  20 PHE B   90  LEU B  105  1                                  16
HELIX   21  21 ASP B  116  ASN B  129  1                                  14
HELIX   22  22 THR B  147  TRP B  151  5                                   5
HELIX   23  23 PRO B  152  ARG B  163  1                                  12
HELIX   24  24 ASP B  166  ILE B  173  1                                   8
HELIX   25  25 ASN B  176  GLY B  181  1                                   6
HELIX   26  26 GLY B  181  GLY B  186  1                                   6
HELIX   27  27 THR B  192  GLU B  201  1                                  10
HELIX   28  28 PRO B  202  LEU B  204  5                                   3
HELIX   29  29 ASN B  205  ASP B  208  5                                   4
HELIX   30  30 ARG B  209  LEU B  219  1                                  11
HELIX   31  31 PRO B  225  SER B  242  1                                  18
HELIX   32  32 PRO B  258  LEU B  269  1                                  12
HELIX   33  33 LEU B  283  ASN B  288  1                                   6
HELIX   34  34 ASN B  288  SER B  301  1                                  14
SHEET    1   A 8 HIS A  23  VAL A  27  0
SHEET    2   A 8 GLU A  30  VAL A  37 -1  O  GLU A  30   N  VAL A  27
SHEET    3   A 8 CYS A  71  PRO A  74 -1  O  CYS A  71   N  VAL A  37
SHEET    4   A 8 VAL A  45  LEU A  48  1  N  PHE A  47   O  ILE A  72
SHEET    5   A 8 VAL A 110  HIS A 115  1  O  VAL A 111   N  LEU A  46
SHEET    6   A 8 ILE A 133  MSE A 139  1  O  ALA A 137   N  LEU A 112
SHEET    7   A 8 LYS A 246  PRO A 253  1  O  LEU A 247   N  PHE A 138
SHEET    8   A 8 CYS A 272  GLY A 280  1  O  ILE A 277   N  TRP A 250
SHEET    1   B 8 HIS B  23  VAL B  27  0
SHEET    2   B 8 GLU B  30  VAL B  37 -1  O  GLU B  30   N  VAL B  27
SHEET    3   B 8 CYS B  71  PRO B  74 -1  O  CYS B  71   N  VAL B  37
SHEET    4   B 8 VAL B  45  LEU B  48  1  N  PHE B  47   O  ILE B  72
SHEET    5   B 8 VAL B 110  HIS B 115  1  O  VAL B 111   N  LEU B  46
SHEET    6   B 8 ILE B 133  MSE B 139  1  O  ALA B 137   N  LEU B 112
SHEET    7   B 8 LYS B 246  PRO B 253  1  O  LEU B 247   N  PHE B 138
SHEET    8   B 8 CYS B 272  GLY B 280  1  O  VAL B 275   N  LEU B 248
LINK         C   ARG A  31                 N   MSE A  32     1555   1555  1.33
LINK         C   MSE A  32                 N   HIS A  33     1555   1555  1.32
LINK         C   GLY A  78                 N   MSE A  79     1555   1555  1.33
LINK         C   MSE A  79                 N   GLY A  80     1555   1555  1.33
LINK         C   PHE A  97                 N   MSE A  98     1555   1555  1.33
LINK         C   MSE A  98                 N   ASP A  99     1555   1555  1.34
LINK         C   PHE A 138                 N   MSE A 139     1555   1555  1.33
LINK         C   MSE A 139                 N   GLU A 140     1555   1555  1.33
LINK         C   PRO A 184                 N  AMSE A 185     1555   1555  1.32
LINK         C   PRO A 184                 N  BMSE A 185     1555   1555  1.33
LINK         C  AMSE A 185                 N   GLY A 186     1555   1555  1.33
LINK         C  BMSE A 185                 N   GLY A 186     1555   1555  1.33
LINK         C   GLU A 195                 N   MSE A 196     1555   1555  1.33
LINK         C   MSE A 196                 N   ASP A 197     1555   1555  1.33
LINK         C   TYR A 235                 N   MSE A 236     1555   1555  1.33
LINK         C   MSE A 236                 N   ASP A 237     1555   1555  1.34
LINK         C   HIS B   0                 N   MSE B   1     1555   1555  1.32
LINK         C   MSE B   1                 N   ALA B  12     1555   1555  1.33
LINK         C   ARG B  31                 N   MSE B  32     1555   1555  1.33
LINK         C   MSE B  32                 N   HIS B  33     1555   1555  1.33
LINK         C   GLY B  78                 N  AMSE B  79     1555   1555  1.33
LINK         C   GLY B  78                 N  BMSE B  79     1555   1555  1.34
LINK         C  AMSE B  79                 N   GLY B  80     1555   1555  1.32
LINK         C  BMSE B  79                 N   GLY B  80     1555   1555  1.33
LINK         C   PHE B  97                 N   MSE B  98     1555   1555  1.33
LINK         C   MSE B  98                 N   ASP B  99     1555   1555  1.33
LINK         C   PHE B 138                 N   MSE B 139     1555   1555  1.32
LINK         C   MSE B 139                 N   GLU B 140     1555   1555  1.33
LINK         C   PRO B 184                 N   MSE B 185     1555   1555  1.32
LINK         C   MSE B 185                 N   GLY B 186     1555   1555  1.33
LINK         C   GLU B 195                 N   MSE B 196     1555   1555  1.33
LINK         C   MSE B 196                 N   ASP B 197     1555   1555  1.33
LINK         C   TYR B 235                 N   MSE B 236     1555   1555  1.33
LINK         C   MSE B 236                 N   ASP B 237     1555   1555  1.33
LINK         OE2 GLU A 224                NA    NA A 402     1555   1555  2.19
LINK         OE2 GLU B 224                NA    NA B 402     1555   1555  2.20
LINK         OD2BASP A  21                NA    NA A 404     1555   1555  2.24
LINK         OD1BASP A  21                NA    NA A 404     1555   1555  2.29
LINK        NA    NA B 403                 O   HOH B 590     1555   1555  2.65
LINK         O   PRO A 184                NA    NA A 403     1555   1555  2.69
LINK        NA    NA B 402                 O   HOH A 592     1555   1555  2.73
LINK        NA    NA A 402                 O   HOH B 581     1555   1555  2.76
LINK         O   ARG A 189                NA    NA A 403     1555   1555  2.78
LINK         O   ASP A  36                NA    NA A 404     1555   1555  2.78
LINK        NA    NA A 402                 O   HOH A 715     1555   1555  2.79
LINK        NA    NA B 403                 O   HOH B 792     1555   1555  2.83
LINK        NA    NA B 402                 O   HOH B 736     1555   1555  2.86
LINK        NA    NA A 404                 O   HOH A 523     1555   1555  2.97
LINK         O   VAL A 187                NA    NA A 403     1555   1555  3.12
LINK        NA    NA A 402                 O   HOH A 536     1555   1555  3.19
LINK        NA    NA B 402                 O   HOH B 540     1555   1555  3.19
CISPEP   1 ASN A   51    PRO A   52          0        -1.10
CISPEP   2 GLU A  224    PRO A  225          0        -5.59
CISPEP   3 THR A  252    PRO A  253          0         6.05
CISPEP   4 SER A  306    GLY A  307          0        -8.34
CISPEP   5 ASN B   51    PRO B   52          0         1.84
CISPEP   6 GLU B  224    PRO B  225          0        -6.15
CISPEP   7 THR B  252    PRO B  253          0         3.29
SITE     1 AC1  4 ASN A  51  ASP A 116  TRP A 117  PRO A 216
SITE     1 AC2  4 GLU A 224  ALA A 226  HOH A 715  HOH B 581
SITE     1 AC3  5 ARG A  40  PRO A 184  VAL A 187  ARG A 189
SITE     2 AC3  5 HOH A 534
SITE     1 AC4  6 ASP A  21  HIS A  23  ASP A  36  MSE A 185
SITE     2 AC4  6  NA A 405  HOH A 523
SITE     1 AC5  4 ASP A  21  VAL A  37  MSE A 185   NA A 404
SITE     1 AC6  5 ASN B  51  ASP B 116  TRP B 117  PHE B 215
SITE     2 AC6  5 PRO B 216
SITE     1 AC7  4 HOH A 592  GLU B 224  ALA B 226  HOH B 736
SITE     1 AC8  3 GLU B 153  HOH B 590  HOH B 792
SITE     1 AC9  7 PHE B  18  SER B  55  ASP B  75  LYS B  81
SITE     2 AC9  7 EDO B 405  HOH B 557  HOH B 744
SITE     1 BC1  7 PHE B  18  PHE B  20  PRO B  22  HIS B  33
SITE     2 BC1  7 LYS B  81  EDO B 404  HOH B 644
SITE     1 BC2 10 HOH A 595  PHE B  91  ASP B  92  ASN B 227
SITE     2 BC2 10 ILE B 228  LEU B 231  HOH B 522  HOH B 582
SITE     3 BC2 10 HOH B 589  HOH B 761
CRYST1   68.930   94.800  100.502  90.00  90.00  90.00 P 21 21 21    8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.014507  0.000000  0.000000        0.00000
SCALE2      0.000000  0.010549  0.000000        0.00000
SCALE3      0.000000  0.000000  0.009950        0.00000
TER    4786      GLY A 307
TER    9587      GLY B 307
MASTER      406    0   26   34   16    0   18    6 5477    2  384   48
END