longtext: 4KE6-pdb

content
HEADER    HYDROLASE                               25-APR-13   4KE6
TITLE     CRYSTAL STRUCTURE D196N MUTANT OF MONOGLYCERIDE LIPASE FROM BACILLUS
TITLE    2 SP. H257 IN COMPLEX WITH 1-RAC-LAUROYL GLYCEROL
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: THERMOSTABLE MONOACYLGLYCEROL LIPASE;
COMPND   3 CHAIN: A, B, C, D, E, F;
COMPND   4 SYNONYM: MGLP;
COMPND   5 EC: 3.1.1.23;
COMPND   6 ENGINEERED: YES;
COMPND   7 MUTATION: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: BACILLUS SP.;
SOURCE   3 ORGANISM_TAXID: 129908;
SOURCE   4 STRAIN: H-257;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE   7 EXPRESSION_SYSTEM_STRAIN: BL21 DE3;
SOURCE   8 EXPRESSION_SYSTEM_VECTOR_TYPE: PET28A(+)
KEYWDS    ALPHA/BETA HYDROLASE FOLD, MONOGLYCERIDE LIPASE, MONOGLYCERIDES,
KEYWDS   2 HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    S.RENGACHARI,P.ASCHAUER,K.GRUBER,I.DREVENY,M.OBERER
REVDAT   1   18-SEP-13 4KE6    0
JRNL        AUTH   S.RENGACHARI,P.ASCHAUER,K.GRUBER,I.DREVENY,M.OBERER
JRNL        TITL   CONFORMATIONAL PLASTICITY AND LIGAND BINDING OF BACTERIAL
JRNL        TITL 2 MONOACYLGLYCEROL LIPASE
JRNL        REF    J.BIOL.CHEM.                               2013
JRNL        REFN                   ESSN 1083-351X
REMARK   2
REMARK   2 RESOLUTION.    2.80 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX (PHENIX.REFINE: 1.8_1069)
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VICENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-
REMARK   3               : KUNSTLEVE,LI-WEI HUNG,ROBERT IMMORMINO,
REMARK   3               : TOM IOERGER,AIRLIE MCCOY,ERIK MCKEE,NIGEL
REMARK   3               : MORIARTY,REETAL PAI,RANDY READ,JANE
REMARK   3               : RICHARDSON,DAVID RICHARDSON,TOD ROMO,JIM
REMARK   3               : SACCHETTINI,NICHOLAS SAUTER,JACOB SMITH,
REMARK   3               : LAURENT STORONI,TOM TERWILLIGER,PETER
REMARK   3               : ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : ML
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.80
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 61.36
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.350
REMARK   3   COMPLETENESS FOR RANGE        (%) : 93.3
REMARK   3   NUMBER OF REFLECTIONS             : 42399
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.202
REMARK   3   R VALUE            (WORKING SET) : 0.200
REMARK   3   FREE R VALUE                     : 0.245
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.080
REMARK   3   FREE R VALUE TEST SET COUNT      : 2152
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 61.3722 -  6.9025    0.87     2764   140  0.1785 0.1969
REMARK   3     2  6.9025 -  5.4798    0.92     2733   129  0.2045 0.2488
REMARK   3     3  5.4798 -  4.7874    0.94     2733   154  0.1758 0.1948
REMARK   3     4  4.7874 -  4.3499    0.96     2727   155  0.1622 0.2029
REMARK   3     5  4.3499 -  4.0381    0.95     2821   128  0.1726 0.2117
REMARK   3     6  4.0381 -  3.8001    0.96     2753   153  0.1877 0.2365
REMARK   3     7  3.8001 -  3.6098    0.97     2749   134  0.2046 0.2649
REMARK   3     8  3.6098 -  3.4527    0.97     2779   155  0.2041 0.2436
REMARK   3     9  3.4527 -  3.3198    0.97     2740   135  0.2102 0.2555
REMARK   3    10  3.3198 -  3.2052    0.97     2753   138  0.2231 0.2852
REMARK   3    11  3.2052 -  3.1050    0.98     2770   155  0.2393 0.3086
REMARK   3    12  3.1050 -  3.0163    0.96     2640   172  0.2566 0.3274
REMARK   3    13  3.0163 -  2.9369    0.84     2460   115  0.2637 0.3407
REMARK   3    14  2.9369 -  2.8652    0.87     2422   144  0.2779 0.3608
REMARK   3    15  2.8652 -  2.8000    0.88     2403   145  0.2780 0.3683
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.370
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 24.780
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 53.06
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.008          11367
REMARK   3   ANGLE     :  1.360          15472
REMARK   3   CHIRALITY :  0.066           1741
REMARK   3   PLANARITY :  0.009           1991
REMARK   3   DIHEDRAL  : 13.933           4144
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 4KE6 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 01-MAY-13.
REMARK 100 THE RCSB ID CODE IS RCSB079225.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 22-MAR-13
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 6.9
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : N
REMARK 200  RADIATION SOURCE               : ROTATING ANODE
REMARK 200  BEAMLINE                       : NULL
REMARK 200  X-RAY GENERATOR MODEL          : BRUKER AXS MICROSTAR
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : NULL
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.54
REMARK 200  MONOCHROMATOR                  : OSMIC MIRROR
REMARK 200  OPTICS                         : MIRRORS
REMARK 200
REMARK 200  DETECTOR TYPE                  : IMAGE PLATE
REMARK 200  DETECTOR MANUFACTURER          : MAR SCANNER 345 MM PLATE
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : MOSFLM
REMARK 200  DATA SCALING SOFTWARE          : SCALA
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 42482
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.800
REMARK 200  RESOLUTION RANGE LOW       (A) : 73.621
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 94.4
REMARK 200  DATA REDUNDANCY                : 3.900
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : 0.09600
REMARK 200   FOR THE DATA SET  : 9.4000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.80
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.95
REMARK 200  COMPLETENESS FOR SHELL     (%) : 87.6
REMARK 200  DATA REDUNDANCY IN SHELL       : 3.10
REMARK 200  R MERGE FOR SHELL          (I) : 0.40100
REMARK 200  R SYM FOR SHELL            (I) : 0.40100
REMARK 200   FOR SHELL         : 1.900
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 51.04
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.51
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: ~0.9 MM OF BMGL(D196N) WAS MIXED WITH
REMARK 280  180 MM 1-(RAC)-LAUROYL GLYCEROL DISSOLVED IN 99% ETOH TO ACHIEVE
REMARK 280  A FINAL PROTEIN-LIGAND RATIO OF 1:5. THE PROTEIN-LIGAND MIXTURE
REMARK 280  WAS INCUBATED AT 4 C FOR 1 HOUR. INITIAL CRYSTALS WERE OBTAINED
REMARK 280  USING THE MORPHEUS SCREEN IN CONDITION A4. THESE CRYSTALS WERE
REMARK 280  USED FOR PREPARING A SEED STOCK. THE OPTIMISED CRYSTALS WERE
REMARK 280  OBTAINED IN A DROP CONTAINING 0.9 MM BMGL(D196N); 56 % V/V MPD,
REMARK 280  0.1 M HEPES PH 6.9 AND 1:1000 DILUTION OF SEED STOCK IN A RATIO
REMARK 280  OF 2:2:1 RESPECTIVELY. 1-LG POWDER WAS ADDED TO THESE
REMARK 280  CRYSTALLIZATION DROPS AND THE CRYSTALS WERE SOAKED FOR 8H., VAPOR
REMARK 280  DIFFUSION, HANGING DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X+1/2,-Y,Z+1/2
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       19.59250
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000      124.13200
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       91.43900
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000      124.13200
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       19.59250
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       91.43900
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3, 4, 5, 6
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 3
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 4
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 5
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: E
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 6
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: F
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A   -19
REMARK 465     GLY A   -18
REMARK 465     SER A   -17
REMARK 465     SER A   -16
REMARK 465     HIS A   -15
REMARK 465     HIS A   -14
REMARK 465     HIS A   -13
REMARK 465     HIS A   -12
REMARK 465     HIS A   -11
REMARK 465     HIS A   -10
REMARK 465     SER A    -9
REMARK 465     SER A    -8
REMARK 465     GLY A    -7
REMARK 465     LEU A    -6
REMARK 465     VAL A    -5
REMARK 465     PRO A    -4
REMARK 465     ARG A    -3
REMARK 465     GLY A    -2
REMARK 465     SER A    -1
REMARK 465     HIS A     0
REMARK 465     THR A   133
REMARK 465     GLY A   134
REMARK 465     GLY A   250
REMARK 465     MET B   -19
REMARK 465     GLY B   -18
REMARK 465     SER B   -17
REMARK 465     SER B   -16
REMARK 465     HIS B   -15
REMARK 465     HIS B   -14
REMARK 465     HIS B   -13
REMARK 465     HIS B   -12
REMARK 465     HIS B   -11
REMARK 465     HIS B   -10
REMARK 465     SER B    -9
REMARK 465     SER B    -8
REMARK 465     GLY B    -7
REMARK 465     LEU B    -6
REMARK 465     VAL B    -5
REMARK 465     PRO B    -4
REMARK 465     ARG B    -3
REMARK 465     GLY B    -2
REMARK 465     SER B    -1
REMARK 465     HIS B     0
REMARK 465     MET B     1
REMARK 465     ALA B   130
REMARK 465     GLY B   131
REMARK 465     MET B   132
REMARK 465     THR B   133
REMARK 465     GLY B   134
REMARK 465     GLY B   135
REMARK 465     GLY B   136
REMARK 465     GLY B   250
REMARK 465     MET C   -19
REMARK 465     GLY C   -18
REMARK 465     SER C   -17
REMARK 465     SER C   -16
REMARK 465     HIS C   -15
REMARK 465     HIS C   -14
REMARK 465     HIS C   -13
REMARK 465     HIS C   -12
REMARK 465     HIS C   -11
REMARK 465     HIS C   -10
REMARK 465     SER C    -9
REMARK 465     SER C    -8
REMARK 465     GLY C    -7
REMARK 465     LEU C    -6
REMARK 465     VAL C    -5
REMARK 465     PRO C    -4
REMARK 465     ARG C    -3
REMARK 465     GLY C    -2
REMARK 465     SER C    -1
REMARK 465     HIS C     0
REMARK 465     MET C     1
REMARK 465     ILE C   128
REMARK 465     ALA C   129
REMARK 465     ALA C   130
REMARK 465     GLY C   131
REMARK 465     MET C   132
REMARK 465     THR C   133
REMARK 465     GLY C   134
REMARK 465     GLY C   135
REMARK 465     GLY C   136
REMARK 465     GLY C   250
REMARK 465     MET D   -19
REMARK 465     GLY D   -18
REMARK 465     SER D   -17
REMARK 465     SER D   -16
REMARK 465     HIS D   -15
REMARK 465     HIS D   -14
REMARK 465     HIS D   -13
REMARK 465     HIS D   -12
REMARK 465     HIS D   -11
REMARK 465     HIS D   -10
REMARK 465     SER D    -9
REMARK 465     SER D    -8
REMARK 465     GLY D    -7
REMARK 465     LEU D    -6
REMARK 465     VAL D    -5
REMARK 465     PRO D    -4
REMARK 465     ARG D    -3
REMARK 465     GLY D    -2
REMARK 465     SER D    -1
REMARK 465     HIS D     0
REMARK 465     MET D     1
REMARK 465     ILE D   128
REMARK 465     ALA D   129
REMARK 465     ALA D   130
REMARK 465     GLY D   131
REMARK 465     MET D   132
REMARK 465     THR D   133
REMARK 465     GLY D   134
REMARK 465     GLY D   135
REMARK 465     GLY D   136
REMARK 465     GLU D   137
REMARK 465     LEU D   138
REMARK 465     GLY D   250
REMARK 465     MET E   -19
REMARK 465     GLY E   -18
REMARK 465     SER E   -17
REMARK 465     SER E   -16
REMARK 465     HIS E   -15
REMARK 465     HIS E   -14
REMARK 465     HIS E   -13
REMARK 465     HIS E   -12
REMARK 465     HIS E   -11
REMARK 465     HIS E   -10
REMARK 465     SER E    -9
REMARK 465     SER E    -8
REMARK 465     GLY E    -7
REMARK 465     LEU E    -6
REMARK 465     VAL E    -5
REMARK 465     PRO E    -4
REMARK 465     ARG E    -3
REMARK 465     GLY E    -2
REMARK 465     SER E    -1
REMARK 465     HIS E     0
REMARK 465     MET E     1
REMARK 465     SER E     2
REMARK 465     GLU E     3
REMARK 465     ILE E   128
REMARK 465     ALA E   129
REMARK 465     ALA E   130
REMARK 465     GLY E   131
REMARK 465     MET E   132
REMARK 465     THR E   133
REMARK 465     GLY E   134
REMARK 465     GLY E   135
REMARK 465     GLY E   136
REMARK 465     GLU E   137
REMARK 465     LEU E   138
REMARK 465     PRO E   139
REMARK 465     ARG E   140
REMARK 465     TYR E   141
REMARK 465     LEU E   142
REMARK 465     ASP E   143
REMARK 465     SER E   144
REMARK 465     ILE E   145
REMARK 465     GLY E   146
REMARK 465     SER E   147
REMARK 465     GLY E   250
REMARK 465     MET F   -19
REMARK 465     GLY F   -18
REMARK 465     SER F   -17
REMARK 465     SER F   -16
REMARK 465     HIS F   -15
REMARK 465     HIS F   -14
REMARK 465     HIS F   -13
REMARK 465     HIS F   -12
REMARK 465     HIS F   -11
REMARK 465     HIS F   -10
REMARK 465     SER F    -9
REMARK 465     SER F    -8
REMARK 465     GLY F    -7
REMARK 465     LEU F    -6
REMARK 465     VAL F    -5
REMARK 465     PRO F    -4
REMARK 465     ARG F    -3
REMARK 465     GLY F    -2
REMARK 465     SER F    -1
REMARK 465     HIS F     0
REMARK 465     MET F     1
REMARK 465     SER F     2
REMARK 465     GLU F     3
REMARK 465     ILE F   128
REMARK 465     ALA F   129
REMARK 465     ALA F   130
REMARK 465     GLY F   131
REMARK 465     MET F   132
REMARK 465     THR F   133
REMARK 465     GLY F   134
REMARK 465     GLY F   135
REMARK 465     GLY F   136
REMARK 465     GLU F   137
REMARK 465     LEU F   138
REMARK 465     PRO F   139
REMARK 465     ARG F   140
REMARK 465     TYR F   141
REMARK 465     LEU F   142
REMARK 465     ASP F   143
REMARK 465     SER F   144
REMARK 465     ILE F   145
REMARK 465     GLY F   146
REMARK 465     GLY F   250
REMARK 480
REMARK 480 ZERO OCCUPANCY ATOM
REMARK 480 THE FOLLOWING RESIDUES HAVE ATOMS MODELED WITH ZERO
REMARK 480 OCCUPANCY. THE LOCATION AND PROPERTIES OF THESE ATOMS
REMARK 480 MAY NOT BE RELIABLE. (M=MODEL NUMBER; RES=RESIDUE NAME;
REMARK 480 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 480   M RES C SSEQI ATOMS
REMARK 480     LYS A   45   CB   CG   CD   CE
REMARK 480     GLN A   89   CD   OE1  NE2
REMARK 480     MET A  132   CB   CG   SD   CE
REMARK 480     LYS A  155   CB   CG   CD   CE
REMARK 480     LYS B   45   CD   CE   NZ
REMARK 480     LYS B   56   CD   CE   NZ
REMARK 480     LEU B  138   CD1  CD2
REMARK 480     LYS B  155   CG   CD   CE   NZ
REMARK 480     ARG B  183   CD   NE   CZ   NH1  NH2
REMARK 480     GLU B  215   CA   CB   CG   CD   OE1  OE2
REMARK 480     GLN C   89   CG   CD   OE1  NE2
REMARK 480     LYS C  155   CB   CG   CD   CE   NZ
REMARK 480     ARG C  183   CB   CG   CD   NE   CZ   NH1  NH2
REMARK 480     ARG C  222   CZ   NH1  NH2
REMARK 480     GLN D   89   CB   CG   CD   OE1  NE2
REMARK 480     CYS D  114   N    CA   C    O    CB   SG
REMARK 480     LYS D  155   CB   CG   CD   CE   NZ
REMARK 480     ARG D  183   CD   NE   CZ   NH1  NH2
REMARK 480     GLN E    4   CB   CG   CD   OE1  NE2
REMARK 480     VAL E    7   CG1  CG2
REMARK 480     LYS E   45   CG   CD   CE   NZ
REMARK 480     LYS E   56   CD   CE   NZ
REMARK 480     TYR E   62   CB   CG   CD1  CD2  CE1  CE2  CZ
REMARK 480     TYR E   62   OH
REMARK 480     GLU E   63   CG   CD   OE1  OE2
REMARK 480     ARG E   67   CG   CD   NE   CZ   NH1  NH2
REMARK 480     LYS E  155   CD   CE   NZ
REMARK 480     LYS E  161   CB   CG   CD   CE   NZ
REMARK 480     ARG E  172   CA   CB   CG   CD   NE   CZ   NH1
REMARK 480     ARG E  172   NH2
REMARK 480     LYS F   45   CG   CD   CE   NZ
REMARK 480     GLN F   89   CB   CG   CD   OE1  NE2
REMARK 480     GLU F  215   CA   CB   CG   CD   OE1  OE2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   OE1  GLU B   137     OG1  THR D    69              1.77
REMARK 500   ND2  ASN C   196     O    VAL C   199              1.95
REMARK 500   O    ALA A   129     N    GLY A   131              2.01
REMARK 500   OG   SER D   144     OG1  THR D   162              2.11
REMARK 500   ND2  ASN A   196     O    VAL A   199              2.18
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    ILE B 125   CG1 -  CB  -  CG2 ANGL. DEV. = -17.5 DEGREES
REMARK 500    PRO C 111   C   -  N   -  CD  ANGL. DEV. = -19.8 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    GLU A   3      133.62    -29.83
REMARK 500    ASN A  18     -112.10   -131.46
REMARK 500    THR A  30       -2.82     70.58
REMARK 500    THR A  60      -78.05   -122.72
REMARK 500    SER A  97     -115.99     60.76
REMARK 500    ALA A 130       20.33     11.46
REMARK 500    VAL A 198      -60.30   -123.83
REMARK 500    TYR A 225     -149.50    -95.60
REMARK 500    ASN B  18     -108.15   -133.53
REMARK 500    THR B  30       -3.94     69.33
REMARK 500    THR B  60      -79.16   -127.84
REMARK 500    SER B  97     -115.87     61.99
REMARK 500    ALA B 127      -49.12   -165.39
REMARK 500    ILE B 128       94.95    -52.78
REMARK 500    VAL B 198      -58.05   -122.39
REMARK 500    TYR B 225     -151.65    -97.66
REMARK 500    ASN C  18     -111.49   -131.80
REMARK 500    THR C  30       -1.42     68.43
REMARK 500    THR C  60      -80.56   -128.08
REMARK 500    SER C  97     -115.71     60.84
REMARK 500    VAL C 198      -59.70   -123.52
REMARK 500    GLU C 215       67.65   -160.43
REMARK 500    GLU C 217      140.38   -171.40
REMARK 500    TYR C 225     -147.32    -96.17
REMARK 500    ASN D  18      -78.54   -130.85
REMARK 500    THR D  30       -2.43     68.91
REMARK 500    THR D  60      -80.11   -126.58
REMARK 500    SER D  97     -114.65     60.02
REMARK 500    ASP D 153       35.29    -97.15
REMARK 500    VAL D 198      -58.88   -123.79
REMARK 500    TYR D 225     -147.63    -99.36
REMARK 500    LEU E   8     -170.22    -66.86
REMARK 500    ASN E  18     -113.77   -130.25
REMARK 500    THR E  30       -0.59     68.99
REMARK 500    THR E  60      -82.46   -123.20
REMARK 500    SER E  97     -112.99     60.78
REMARK 500    ASP E 153       34.73    -81.93
REMARK 500    LEU E 157      104.52    -54.77
REMARK 500    VAL E 198      -59.48   -121.72
REMARK 500    TYR E 225     -146.09    -98.64
REMARK 500    ASN F  18     -109.38   -132.05
REMARK 500    THR F  60      -77.72   -126.66
REMARK 500    SER F  97     -112.92     58.73
REMARK 500    LEU F 173      -54.56    -25.68
REMARK 500    VAL F 198      -56.91   -124.20
REMARK 500    PRO F 201       -7.74    -58.43
REMARK 500    TYR F 225     -149.44    -92.65
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY
REMARK 500
REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY
REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER
REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME;
REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 500 I=INSERTION CODE).
REMARK 500
REMARK 500  M RES CSSEQI        ANGLE
REMARK 500    HIS B 110         10.02
REMARK 500    ASN E  18         12.45
REMARK 500
REMARK 500 REMARK: NULL
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE 1QW A 301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MPD C 301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MPD E 301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MPD F 301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MPD F 302
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 4KE7   RELATED DB: PDB
REMARK 900 RELATED ID: 4KE8   RELATED DB: PDB
REMARK 900 RELATED ID: 4KE9   RELATED DB: PDB
REMARK 900 RELATED ID: 4KEA   RELATED DB: PDB
DBREF  4KE6 A    1   250  UNP    P82597   MGLP_BAC25       1    250
DBREF  4KE6 B    1   250  UNP    P82597   MGLP_BAC25       1    250
DBREF  4KE6 C    1   250  UNP    P82597   MGLP_BAC25       1    250
DBREF  4KE6 D    1   250  UNP    P82597   MGLP_BAC25       1    250
DBREF  4KE6 E    1   250  UNP    P82597   MGLP_BAC25       1    250
DBREF  4KE6 F    1   250  UNP    P82597   MGLP_BAC25       1    250
SEQADV 4KE6 MET A  -19  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 GLY A  -18  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER A  -17  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER A  -16  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS A  -15  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS A  -14  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS A  -13  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS A  -12  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS A  -11  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS A  -10  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER A   -9  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER A   -8  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 GLY A   -7  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 LEU A   -6  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 VAL A   -5  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 PRO A   -4  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 ARG A   -3  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 GLY A   -2  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER A   -1  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS A    0  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 ASN A  196  UNP  P82597    ASP   196 ENGINEERED MUTATION
SEQADV 4KE6 MET B  -19  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 GLY B  -18  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER B  -17  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER B  -16  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS B  -15  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS B  -14  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS B  -13  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS B  -12  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS B  -11  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS B  -10  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER B   -9  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER B   -8  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 GLY B   -7  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 LEU B   -6  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 VAL B   -5  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 PRO B   -4  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 ARG B   -3  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 GLY B   -2  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER B   -1  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS B    0  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 ASN B  196  UNP  P82597    ASP   196 ENGINEERED MUTATION
SEQADV 4KE6 MET C  -19  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 GLY C  -18  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER C  -17  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER C  -16  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS C  -15  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS C  -14  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS C  -13  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS C  -12  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS C  -11  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS C  -10  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER C   -9  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER C   -8  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 GLY C   -7  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 LEU C   -6  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 VAL C   -5  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 PRO C   -4  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 ARG C   -3  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 GLY C   -2  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER C   -1  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS C    0  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 ASN C  196  UNP  P82597    ASP   196 ENGINEERED MUTATION
SEQADV 4KE6 MET D  -19  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 GLY D  -18  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER D  -17  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER D  -16  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS D  -15  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS D  -14  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS D  -13  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS D  -12  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS D  -11  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS D  -10  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER D   -9  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER D   -8  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 GLY D   -7  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 LEU D   -6  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 VAL D   -5  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 PRO D   -4  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 ARG D   -3  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 GLY D   -2  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER D   -1  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS D    0  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 ASN D  196  UNP  P82597    ASP   196 ENGINEERED MUTATION
SEQADV 4KE6 MET E  -19  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 GLY E  -18  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER E  -17  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER E  -16  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS E  -15  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS E  -14  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS E  -13  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS E  -12  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS E  -11  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS E  -10  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER E   -9  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER E   -8  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 GLY E   -7  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 LEU E   -6  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 VAL E   -5  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 PRO E   -4  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 ARG E   -3  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 GLY E   -2  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER E   -1  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS E    0  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 ASN E  196  UNP  P82597    ASP   196 ENGINEERED MUTATION
SEQADV 4KE6 MET F  -19  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 GLY F  -18  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER F  -17  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER F  -16  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS F  -15  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS F  -14  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS F  -13  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS F  -12  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS F  -11  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS F  -10  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER F   -9  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER F   -8  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 GLY F   -7  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 LEU F   -6  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 VAL F   -5  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 PRO F   -4  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 ARG F   -3  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 GLY F   -2  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 SER F   -1  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 HIS F    0  UNP  P82597              EXPRESSION TAG
SEQADV 4KE6 ASN F  196  UNP  P82597    ASP   196 ENGINEERED MUTATION
SEQRES   1 A  270  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 A  270  LEU VAL PRO ARG GLY SER HIS MET SER GLU GLN TYR PRO
SEQRES   3 A  270  VAL LEU SER GLY ALA GLU PRO PHE TYR ALA GLU ASN GLY
SEQRES   4 A  270  PRO VAL GLY VAL LEU LEU VAL HIS GLY PHE THR GLY THR
SEQRES   5 A  270  PRO HIS SER MET ARG PRO LEU ALA GLU ALA TYR ALA LYS
SEQRES   6 A  270  ALA GLY TYR THR VAL CYS LEU PRO ARG LEU LYS GLY HIS
SEQRES   7 A  270  GLY THR HIS TYR GLU ASP MET GLU ARG THR THR PHE HIS
SEQRES   8 A  270  ASP TRP VAL ALA SER VAL GLU GLU GLY TYR GLY TRP LEU
SEQRES   9 A  270  LYS GLN ARG CYS GLN THR ILE PHE VAL THR GLY LEU SER
SEQRES  10 A  270  MET GLY GLY THR LEU THR LEU TYR LEU ALA GLU HIS HIS
SEQRES  11 A  270  PRO ASP ILE CYS GLY ILE VAL PRO ILE ASN ALA ALA VAL
SEQRES  12 A  270  ASP ILE PRO ALA ILE ALA ALA GLY MET THR GLY GLY GLY
SEQRES  13 A  270  GLU LEU PRO ARG TYR LEU ASP SER ILE GLY SER ASP LEU
SEQRES  14 A  270  LYS ASN PRO ASP VAL LYS GLU LEU ALA TYR GLU LYS THR
SEQRES  15 A  270  PRO THR ALA SER LEU LEU GLN LEU ALA ARG LEU MET ALA
SEQRES  16 A  270  GLN THR LYS ALA LYS LEU ASP ARG ILE VAL CYS PRO ALA
SEQRES  17 A  270  LEU ILE PHE VAL SER ASP GLU ASN HIS VAL VAL PRO PRO
SEQRES  18 A  270  GLY ASN ALA ASP ILE ILE PHE GLN GLY ILE SER SER THR
SEQRES  19 A  270  GLU LYS GLU ILE VAL ARG LEU ARG ASN SER TYR HIS VAL
SEQRES  20 A  270  ALA THR LEU ASP TYR ASP GLN PRO MET ILE ILE GLU ARG
SEQRES  21 A  270  SER LEU GLU PHE PHE ALA LYS HIS ALA GLY
SEQRES   1 B  270  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 B  270  LEU VAL PRO ARG GLY SER HIS MET SER GLU GLN TYR PRO
SEQRES   3 B  270  VAL LEU SER GLY ALA GLU PRO PHE TYR ALA GLU ASN GLY
SEQRES   4 B  270  PRO VAL GLY VAL LEU LEU VAL HIS GLY PHE THR GLY THR
SEQRES   5 B  270  PRO HIS SER MET ARG PRO LEU ALA GLU ALA TYR ALA LYS
SEQRES   6 B  270  ALA GLY TYR THR VAL CYS LEU PRO ARG LEU LYS GLY HIS
SEQRES   7 B  270  GLY THR HIS TYR GLU ASP MET GLU ARG THR THR PHE HIS
SEQRES   8 B  270  ASP TRP VAL ALA SER VAL GLU GLU GLY TYR GLY TRP LEU
SEQRES   9 B  270  LYS GLN ARG CYS GLN THR ILE PHE VAL THR GLY LEU SER
SEQRES  10 B  270  MET GLY GLY THR LEU THR LEU TYR LEU ALA GLU HIS HIS
SEQRES  11 B  270  PRO ASP ILE CYS GLY ILE VAL PRO ILE ASN ALA ALA VAL
SEQRES  12 B  270  ASP ILE PRO ALA ILE ALA ALA GLY MET THR GLY GLY GLY
SEQRES  13 B  270  GLU LEU PRO ARG TYR LEU ASP SER ILE GLY SER ASP LEU
SEQRES  14 B  270  LYS ASN PRO ASP VAL LYS GLU LEU ALA TYR GLU LYS THR
SEQRES  15 B  270  PRO THR ALA SER LEU LEU GLN LEU ALA ARG LEU MET ALA
SEQRES  16 B  270  GLN THR LYS ALA LYS LEU ASP ARG ILE VAL CYS PRO ALA
SEQRES  17 B  270  LEU ILE PHE VAL SER ASP GLU ASN HIS VAL VAL PRO PRO
SEQRES  18 B  270  GLY ASN ALA ASP ILE ILE PHE GLN GLY ILE SER SER THR
SEQRES  19 B  270  GLU LYS GLU ILE VAL ARG LEU ARG ASN SER TYR HIS VAL
SEQRES  20 B  270  ALA THR LEU ASP TYR ASP GLN PRO MET ILE ILE GLU ARG
SEQRES  21 B  270  SER LEU GLU PHE PHE ALA LYS HIS ALA GLY
SEQRES   1 C  270  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 C  270  LEU VAL PRO ARG GLY SER HIS MET SER GLU GLN TYR PRO
SEQRES   3 C  270  VAL LEU SER GLY ALA GLU PRO PHE TYR ALA GLU ASN GLY
SEQRES   4 C  270  PRO VAL GLY VAL LEU LEU VAL HIS GLY PHE THR GLY THR
SEQRES   5 C  270  PRO HIS SER MET ARG PRO LEU ALA GLU ALA TYR ALA LYS
SEQRES   6 C  270  ALA GLY TYR THR VAL CYS LEU PRO ARG LEU LYS GLY HIS
SEQRES   7 C  270  GLY THR HIS TYR GLU ASP MET GLU ARG THR THR PHE HIS
SEQRES   8 C  270  ASP TRP VAL ALA SER VAL GLU GLU GLY TYR GLY TRP LEU
SEQRES   9 C  270  LYS GLN ARG CYS GLN THR ILE PHE VAL THR GLY LEU SER
SEQRES  10 C  270  MET GLY GLY THR LEU THR LEU TYR LEU ALA GLU HIS HIS
SEQRES  11 C  270  PRO ASP ILE CYS GLY ILE VAL PRO ILE ASN ALA ALA VAL
SEQRES  12 C  270  ASP ILE PRO ALA ILE ALA ALA GLY MET THR GLY GLY GLY
SEQRES  13 C  270  GLU LEU PRO ARG TYR LEU ASP SER ILE GLY SER ASP LEU
SEQRES  14 C  270  LYS ASN PRO ASP VAL LYS GLU LEU ALA TYR GLU LYS THR
SEQRES  15 C  270  PRO THR ALA SER LEU LEU GLN LEU ALA ARG LEU MET ALA
SEQRES  16 C  270  GLN THR LYS ALA LYS LEU ASP ARG ILE VAL CYS PRO ALA
SEQRES  17 C  270  LEU ILE PHE VAL SER ASP GLU ASN HIS VAL VAL PRO PRO
SEQRES  18 C  270  GLY ASN ALA ASP ILE ILE PHE GLN GLY ILE SER SER THR
SEQRES  19 C  270  GLU LYS GLU ILE VAL ARG LEU ARG ASN SER TYR HIS VAL
SEQRES  20 C  270  ALA THR LEU ASP TYR ASP GLN PRO MET ILE ILE GLU ARG
SEQRES  21 C  270  SER LEU GLU PHE PHE ALA LYS HIS ALA GLY
SEQRES   1 D  270  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 D  270  LEU VAL PRO ARG GLY SER HIS MET SER GLU GLN TYR PRO
SEQRES   3 D  270  VAL LEU SER GLY ALA GLU PRO PHE TYR ALA GLU ASN GLY
SEQRES   4 D  270  PRO VAL GLY VAL LEU LEU VAL HIS GLY PHE THR GLY THR
SEQRES   5 D  270  PRO HIS SER MET ARG PRO LEU ALA GLU ALA TYR ALA LYS
SEQRES   6 D  270  ALA GLY TYR THR VAL CYS LEU PRO ARG LEU LYS GLY HIS
SEQRES   7 D  270  GLY THR HIS TYR GLU ASP MET GLU ARG THR THR PHE HIS
SEQRES   8 D  270  ASP TRP VAL ALA SER VAL GLU GLU GLY TYR GLY TRP LEU
SEQRES   9 D  270  LYS GLN ARG CYS GLN THR ILE PHE VAL THR GLY LEU SER
SEQRES  10 D  270  MET GLY GLY THR LEU THR LEU TYR LEU ALA GLU HIS HIS
SEQRES  11 D  270  PRO ASP ILE CYS GLY ILE VAL PRO ILE ASN ALA ALA VAL
SEQRES  12 D  270  ASP ILE PRO ALA ILE ALA ALA GLY MET THR GLY GLY GLY
SEQRES  13 D  270  GLU LEU PRO ARG TYR LEU ASP SER ILE GLY SER ASP LEU
SEQRES  14 D  270  LYS ASN PRO ASP VAL LYS GLU LEU ALA TYR GLU LYS THR
SEQRES  15 D  270  PRO THR ALA SER LEU LEU GLN LEU ALA ARG LEU MET ALA
SEQRES  16 D  270  GLN THR LYS ALA LYS LEU ASP ARG ILE VAL CYS PRO ALA
SEQRES  17 D  270  LEU ILE PHE VAL SER ASP GLU ASN HIS VAL VAL PRO PRO
SEQRES  18 D  270  GLY ASN ALA ASP ILE ILE PHE GLN GLY ILE SER SER THR
SEQRES  19 D  270  GLU LYS GLU ILE VAL ARG LEU ARG ASN SER TYR HIS VAL
SEQRES  20 D  270  ALA THR LEU ASP TYR ASP GLN PRO MET ILE ILE GLU ARG
SEQRES  21 D  270  SER LEU GLU PHE PHE ALA LYS HIS ALA GLY
SEQRES   1 E  270  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 E  270  LEU VAL PRO ARG GLY SER HIS MET SER GLU GLN TYR PRO
SEQRES   3 E  270  VAL LEU SER GLY ALA GLU PRO PHE TYR ALA GLU ASN GLY
SEQRES   4 E  270  PRO VAL GLY VAL LEU LEU VAL HIS GLY PHE THR GLY THR
SEQRES   5 E  270  PRO HIS SER MET ARG PRO LEU ALA GLU ALA TYR ALA LYS
SEQRES   6 E  270  ALA GLY TYR THR VAL CYS LEU PRO ARG LEU LYS GLY HIS
SEQRES   7 E  270  GLY THR HIS TYR GLU ASP MET GLU ARG THR THR PHE HIS
SEQRES   8 E  270  ASP TRP VAL ALA SER VAL GLU GLU GLY TYR GLY TRP LEU
SEQRES   9 E  270  LYS GLN ARG CYS GLN THR ILE PHE VAL THR GLY LEU SER
SEQRES  10 E  270  MET GLY GLY THR LEU THR LEU TYR LEU ALA GLU HIS HIS
SEQRES  11 E  270  PRO ASP ILE CYS GLY ILE VAL PRO ILE ASN ALA ALA VAL
SEQRES  12 E  270  ASP ILE PRO ALA ILE ALA ALA GLY MET THR GLY GLY GLY
SEQRES  13 E  270  GLU LEU PRO ARG TYR LEU ASP SER ILE GLY SER ASP LEU
SEQRES  14 E  270  LYS ASN PRO ASP VAL LYS GLU LEU ALA TYR GLU LYS THR
SEQRES  15 E  270  PRO THR ALA SER LEU LEU GLN LEU ALA ARG LEU MET ALA
SEQRES  16 E  270  GLN THR LYS ALA LYS LEU ASP ARG ILE VAL CYS PRO ALA
SEQRES  17 E  270  LEU ILE PHE VAL SER ASP GLU ASN HIS VAL VAL PRO PRO
SEQRES  18 E  270  GLY ASN ALA ASP ILE ILE PHE GLN GLY ILE SER SER THR
SEQRES  19 E  270  GLU LYS GLU ILE VAL ARG LEU ARG ASN SER TYR HIS VAL
SEQRES  20 E  270  ALA THR LEU ASP TYR ASP GLN PRO MET ILE ILE GLU ARG
SEQRES  21 E  270  SER LEU GLU PHE PHE ALA LYS HIS ALA GLY
SEQRES   1 F  270  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 F  270  LEU VAL PRO ARG GLY SER HIS MET SER GLU GLN TYR PRO
SEQRES   3 F  270  VAL LEU SER GLY ALA GLU PRO PHE TYR ALA GLU ASN GLY
SEQRES   4 F  270  PRO VAL GLY VAL LEU LEU VAL HIS GLY PHE THR GLY THR
SEQRES   5 F  270  PRO HIS SER MET ARG PRO LEU ALA GLU ALA TYR ALA LYS
SEQRES   6 F  270  ALA GLY TYR THR VAL CYS LEU PRO ARG LEU LYS GLY HIS
SEQRES   7 F  270  GLY THR HIS TYR GLU ASP MET GLU ARG THR THR PHE HIS
SEQRES   8 F  270  ASP TRP VAL ALA SER VAL GLU GLU GLY TYR GLY TRP LEU
SEQRES   9 F  270  LYS GLN ARG CYS GLN THR ILE PHE VAL THR GLY LEU SER
SEQRES  10 F  270  MET GLY GLY THR LEU THR LEU TYR LEU ALA GLU HIS HIS
SEQRES  11 F  270  PRO ASP ILE CYS GLY ILE VAL PRO ILE ASN ALA ALA VAL
SEQRES  12 F  270  ASP ILE PRO ALA ILE ALA ALA GLY MET THR GLY GLY GLY
SEQRES  13 F  270  GLU LEU PRO ARG TYR LEU ASP SER ILE GLY SER ASP LEU
SEQRES  14 F  270  LYS ASN PRO ASP VAL LYS GLU LEU ALA TYR GLU LYS THR
SEQRES  15 F  270  PRO THR ALA SER LEU LEU GLN LEU ALA ARG LEU MET ALA
SEQRES  16 F  270  GLN THR LYS ALA LYS LEU ASP ARG ILE VAL CYS PRO ALA
SEQRES  17 F  270  LEU ILE PHE VAL SER ASP GLU ASN HIS VAL VAL PRO PRO
SEQRES  18 F  270  GLY ASN ALA ASP ILE ILE PHE GLN GLY ILE SER SER THR
SEQRES  19 F  270  GLU LYS GLU ILE VAL ARG LEU ARG ASN SER TYR HIS VAL
SEQRES  20 F  270  ALA THR LEU ASP TYR ASP GLN PRO MET ILE ILE GLU ARG
SEQRES  21 F  270  SER LEU GLU PHE PHE ALA LYS HIS ALA GLY
HET    1QW  A 301      19
HET    MPD  C 301       8
HET    MPD  E 301       8
HET    MPD  F 301       8
HET    MPD  F 302       8
HETNAM     1QW (2R)-2,3-DIHYDROXYPROPYL DODECANOATE
HETNAM     MPD (4S)-2-METHYL-2,4-PENTANEDIOL
HETSYN     1QW 1-LAUROYL-RAC-GLYCEROL
FORMUL   7  1QW    C15 H30 O4
FORMUL   8  MPD    4(C6 H14 O2)
FORMUL  12  HOH   *31(H2 O)
HELIX    1   1 THR A   32  SER A   35  5                                   4
HELIX    2   2 MET A   36  ALA A   46  1                                  11
HELIX    3   3 HIS A   61  THR A   68  1                                   8
HELIX    4   4 THR A   69  GLN A   86  1                                  18
HELIX    5   5 SER A   97  HIS A  110  1                                  14
HELIX    6   6 ILE A  125  ALA A  130  1                                   6
HELIX    7   7 THR A  164  LYS A  180  1                                  17
HELIX    8   8 LEU A  181  ILE A  184  5                                   4
HELIX    9   9 GLY A  202  ILE A  211  1                                  10
HELIX   10  10 VAL A  227  ASP A  231  5                                   5
HELIX   11  11 ASP A  233  ALA A  249  1                                  17
HELIX   12  12 THR B   32  SER B   35  5                                   4
HELIX   13  13 MET B   36  ALA B   46  1                                  11
HELIX   14  14 HIS B   61  ARG B   67  1                                   7
HELIX   15  15 THR B   69  GLN B   86  1                                  18
HELIX   16  16 SER B   97  HIS B  110  1                                  14
HELIX   17  17 THR B  164  LYS B  180  1                                  17
HELIX   18  18 LEU B  181  ILE B  184  5                                   4
HELIX   19  19 PRO B  201  ILE B  211  1                                  11
HELIX   20  20 VAL B  227  ASP B  231  5                                   5
HELIX   21  21 ASP B  233  ALA B  249  1                                  17
HELIX   22  22 THR C   32  SER C   35  5                                   4
HELIX   23  23 MET C   36  ALA C   46  1                                  11
HELIX   24  24 HIS C   61  ARG C   67  1                                   7
HELIX   25  25 THR C   69  GLN C   86  1                                  18
HELIX   26  26 SER C   97  HIS C  110  1                                  14
HELIX   27  27 THR C  164  LYS C  180  1                                  17
HELIX   28  28 LEU C  181  ILE C  184  5                                   4
HELIX   29  29 PRO C  201  ILE C  211  1                                  11
HELIX   30  30 VAL C  227  ASP C  231  5                                   5
HELIX   31  31 ASP C  233  ALA C  249  1                                  17
HELIX   32  32 THR D   32  SER D   35  5                                   4
HELIX   33  33 MET D   36  ALA D   46  1                                  11
HELIX   34  34 HIS D   61  ARG D   67  1                                   7
HELIX   35  35 THR D   69  GLN D   86  1                                  18
HELIX   36  36 SER D   97  GLU D  108  1                                  12
HELIX   37  37 THR D  164  LYS D  180  1                                  17
HELIX   38  38 LEU D  181  ILE D  184  5                                   4
HELIX   39  39 GLY D  202  ILE D  211  1                                  10
HELIX   40  40 ASP D  233  ALA D  249  1                                  17
HELIX   41  41 THR E   32  SER E   35  5                                   4
HELIX   42  42 MET E   36  ALA E   46  1                                  11
HELIX   43  43 HIS E   61  ARG E   67  1                                   7
HELIX   44  44 THR E   69  GLN E   86  1                                  18
HELIX   45  45 SER E   97  HIS E  110  1                                  14
HELIX   46  46 PRO E  163  LYS E  180  1                                  18
HELIX   47  47 LEU E  181  ILE E  184  5                                   4
HELIX   48  48 GLY E  202  ILE E  211  1                                  10
HELIX   49  49 VAL E  227  ASP E  231  5                                   5
HELIX   50  50 ASP E  233  ALA E  249  1                                  17
HELIX   51  51 THR F   32  SER F   35  5                                   4
HELIX   52  52 MET F   36  GLY F   47  1                                  12
HELIX   53  53 HIS F   61  ARG F   67  1                                   7
HELIX   54  54 THR F   69  GLN F   86  1                                  18
HELIX   55  55 SER F   97  GLU F  108  1                                  12
HELIX   56  56 PRO F  163  LYS F  180  1                                  18
HELIX   57  57 LEU F  181  ILE F  184  5                                   4
HELIX   58  58 PRO F  201  ILE F  211  1                                  11
HELIX   59  59 VAL F  227  ASP F  231  5                                   5
HELIX   60  60 ASP F  233  ALA F  249  1                                  17
SHEET    1   A 5 PHE A  14  ALA A  16  0
SHEET    2   A 5 THR A  49  LEU A  52 -1  O  LEU A  52   N  PHE A  14
SHEET    3   A 5 VAL A  21  VAL A  26  1  N  VAL A  23   O  CYS A  51
SHEET    4   A 5 THR A  90  LEU A  96  1  O  THR A  90   N  GLY A  22
SHEET    5   A 5 ILE A 113  ILE A 119  1  O  CYS A 114   N  ILE A  91
SHEET    1   B 2 TYR A 141  ASP A 143  0
SHEET    2   B 2 LYS A 161  PRO A 163 -1  O  THR A 162   N  LEU A 142
SHEET    1   C 4 ALA A 188  SER A 193  0
SHEET    2   C 4 GLU A 215  LEU A 221  1  O  GLU A 217   N  ILE A 190
SHEET    3   C 4 GLU B 215  LEU B 221 -1  O  ILE B 218   N  LYS A 216
SHEET    4   C 4 ALA B 188  SER B 193  1  N  ILE B 190   O  GLU B 217
SHEET    1   D 5 PHE B  14  ALA B  16  0
SHEET    2   D 5 THR B  49  LEU B  52 -1  O  LEU B  52   N  PHE B  14
SHEET    3   D 5 VAL B  21  VAL B  26  1  N  LEU B  25   O  CYS B  51
SHEET    4   D 5 THR B  90  LEU B  96  1  O  PHE B  92   N  LEU B  24
SHEET    5   D 5 GLY B 115  ILE B 119  1  O  VAL B 117   N  VAL B  93
SHEET    1   E 2 TYR B 141  ASP B 143  0
SHEET    2   E 2 LYS B 161  PRO B 163 -1  O  THR B 162   N  LEU B 142
SHEET    1   F 5 PHE C  14  ALA C  16  0
SHEET    2   F 5 THR C  49  LEU C  52 -1  O  LEU C  52   N  PHE C  14
SHEET    3   F 5 VAL C  21  VAL C  26  1  N  LEU C  25   O  CYS C  51
SHEET    4   F 5 THR C  90  LEU C  96  1  O  THR C  90   N  GLY C  22
SHEET    5   F 5 GLY C 115  ILE C 119  1  O  ILE C 119   N  GLY C  95
SHEET    1   G 2 TYR C 141  ASP C 143  0
SHEET    2   G 2 LYS C 161  PRO C 163 -1  O  THR C 162   N  LEU C 142
SHEET    1   H 4 ILE C 190  SER C 193  0
SHEET    2   H 4 GLU C 215  LEU C 221  1  O  GLU C 217   N  ILE C 190
SHEET    3   H 4 GLU F 215  LEU F 221 -1  O  LYS F 216   N  ILE C 218
SHEET    4   H 4 ALA F 188  SER F 193  1  N  ILE F 190   O  GLU F 217
SHEET    1   I 5 PHE D  14  ALA D  16  0
SHEET    2   I 5 THR D  49  LEU D  52 -1  O  LEU D  52   N  PHE D  14
SHEET    3   I 5 VAL D  21  VAL D  26  1  N  LEU D  25   O  CYS D  51
SHEET    4   I 5 THR D  90  LEU D  96  1  O  THR D  94   N  LEU D  24
SHEET    5   I 5 ILE D 113  ILE D 119  1  O  ILE D 119   N  GLY D  95
SHEET    1   J 2 TYR D 141  ASP D 143  0
SHEET    2   J 2 LYS D 161  PRO D 163 -1  O  THR D 162   N  LEU D 142
SHEET    1   K 4 ALA D 188  SER D 193  0
SHEET    2   K 4 GLU D 215  LEU D 221  1  O  LEU D 221   N  VAL D 192
SHEET    3   K 4 GLU E 215  LEU E 221 -1  O  ILE E 218   N  LYS D 216
SHEET    4   K 4 ALA E 188  SER E 193  1  N  VAL E 192   O  LEU E 221
SHEET    1   L 5 PHE E  14  ALA E  16  0
SHEET    2   L 5 THR E  49  LEU E  52 -1  O  LEU E  52   N  PHE E  14
SHEET    3   L 5 VAL E  21  VAL E  26  1  N  VAL E  21   O  THR E  49
SHEET    4   L 5 THR E  90  LEU E  96  1  O  PHE E  92   N  LEU E  24
SHEET    5   L 5 GLY E 115  ILE E 119  1  O  VAL E 117   N  VAL E  93
SHEET    1   M 5 PHE F  14  ALA F  16  0
SHEET    2   M 5 THR F  49  LEU F  52 -1  O  LEU F  52   N  PHE F  14
SHEET    3   M 5 VAL F  21  VAL F  26  1  N  VAL F  21   O  THR F  49
SHEET    4   M 5 THR F  90  LEU F  96  1  O  THR F  94   N  LEU F  24
SHEET    5   M 5 GLY F 115  ILE F 119  1  O  ILE F 119   N  GLY F  95
CISPEP   1 GLY D  146    SER D  147          0         3.27
SITE     1 AC1  8 GLY A  28  PHE A  29  SER A  97  MET A  98
SITE     2 AC1  8 ILE A 128  SER A 147  GLU A 156  ASP C 143
SITE     1 AC2  3 SER C  97  ILE C 145  LEU C 167
SITE     1 AC3  6 VAL E  21  GLY E  47  TYR E  48  VAL F  21
SITE     2 AC3  6 ALA F  46  TYR F  48
SITE     1 AC4  2 LYS F 161  MPD F 302
SITE     1 AC5  2 THR F 164  MPD F 301
CRYST1   39.185  182.878  248.264  90.00  90.00  90.00 P 21 21 21   24
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.025520  0.000000  0.000000        0.00000
SCALE2      0.000000  0.005468  0.000000        0.00000
SCALE3      0.000000  0.000000  0.004028        0.00000
TER    1910      ALA A 249
TER    3793      ALA B 249
TER    5657      ALA C 249
TER    7510      ALA D 249
TER    9272      ALA E 249
TER   11046      ALA F 249
MASTER      648    0    5   60   50    0    7    611104    6   51  126
END