longtext: 4KE8-pdb

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HEADER    HYDROLASE                               25-APR-13   4KE8
TITLE     CRYSTAL STRUCTURE OF MONOGLYCERIDE LIPASE FROM BACILLUS SP. H257 IN
TITLE    2 COMPLEX WITH MONOPALMITOYL GLYCEROL ANALOGUE
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: THERMOSTABLE MONOACYLGLYCEROL LIPASE;
COMPND   3 CHAIN: A, B, C, D;
COMPND   4 SYNONYM: MGLP;
COMPND   5 EC: 3.1.1.23;
COMPND   6 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: BACILLUS SP.;
SOURCE   3 ORGANISM_TAXID: 129908;
SOURCE   4 STRAIN: H-257;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE   7 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);
SOURCE   8 EXPRESSION_SYSTEM_VECTOR_TYPE: PET28A(+)
KEYWDS    ALPHA/BETA HYDROLASE, MONOGLYCERIDE LIPASE, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    S.RENGACHARI,P.ASCHAUER,K.GRUBER,I.DREVENY,M.OBERER
REVDAT   1   18-SEP-13 4KE8    0
JRNL        AUTH   S.RENGACHARI,P.ASCHAUER,K.GRUBER,I.DREVENY,M.OBERER
JRNL        TITL   CONFORMATIONAL PLASTICITY AND LIGAND BINDING OF BACTERIAL
JRNL        TITL 2 MONOACYLGLYCEROL LIPASE
JRNL        REF    J.BIOL.CHEM.                               2013
JRNL        REFN                   ESSN 1083-351X
REMARK   2
REMARK   2 RESOLUTION.    1.85 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX (PHENIX.REFINE: 1.8.2_1309)
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VICENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-
REMARK   3               : KUNSTLEVE,LI-WEI HUNG,ROBERT IMMORMINO,
REMARK   3               : TOM IOERGER,AIRLIE MCCOY,ERIK MCKEE,NIGEL
REMARK   3               : MORIARTY,REETAL PAI,RANDY READ,JANE
REMARK   3               : RICHARDSON,DAVID RICHARDSON,TOD ROMO,JIM
REMARK   3               : SACCHETTINI,NICHOLAS SAUTER,JACOB SMITH,
REMARK   3               : LAURENT STORONI,TOM TERWILLIGER,PETER
REMARK   3               : ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : ML
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.85
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 43.74
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.500
REMARK   3   COMPLETENESS FOR RANGE        (%) : 92.0
REMARK   3   NUMBER OF REFLECTIONS             : 81489
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.181
REMARK   3   R VALUE            (WORKING SET) : 0.180
REMARK   3   FREE R VALUE                     : 0.220
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 2.450
REMARK   3   FREE R VALUE TEST SET COUNT      : 1999
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 43.7488 -  4.4573    0.98     6179   155  0.1397 0.1604
REMARK   3     2  4.4573 -  3.5384    0.98     6061   153  0.1488 0.1773
REMARK   3     3  3.5384 -  3.0912    0.98     6104   152  0.1792 0.2359
REMARK   3     4  3.0912 -  2.8087    0.98     6042   153  0.1930 0.2314
REMARK   3     5  2.8087 -  2.6074    0.98     6014   151  0.1872 0.2384
REMARK   3     6  2.6074 -  2.4537    0.96     5924   148  0.1833 0.2284
REMARK   3     7  2.4537 -  2.3308    0.96     5909   150  0.1826 0.1970
REMARK   3     8  2.3308 -  2.2293    0.90     5517   138  0.2034 0.2738
REMARK   3     9  2.2293 -  2.1435    0.87     5363   136  0.1924 0.2656
REMARK   3    10  2.1435 -  2.0696    0.93     5715   143  0.2039 0.2350
REMARK   3    11  2.0696 -  2.0048    0.90     5532   139  0.2095 0.2556
REMARK   3    12  2.0048 -  1.9475    0.86     5269   133  0.2259 0.2975
REMARK   3    13  1.9475 -  1.8963    0.83     5092   128  0.2704 0.2724
REMARK   3    14  1.8963 -  1.8500    0.77     4769   120  0.2438 0.3056
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.180
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 26.860
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -9.43920
REMARK   3    B22 (A**2) : 17.27940
REMARK   3    B33 (A**2) : -7.84030
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.43050
REMARK   3    B23 (A**2) : -0.00000
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.007           7951
REMARK   3   ANGLE     :  1.043          10811
REMARK   3   CHIRALITY :  0.065           1202
REMARK   3   PLANARITY :  0.005           1391
REMARK   3   DIHEDRAL  : 13.402           2855
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 4KE8 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 01-MAY-13.
REMARK 100 THE RCSB ID CODE IS RCSB079227.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 01-APR-12
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 5.2
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SLS
REMARK 200  BEAMLINE                       : X06DA
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.0
REMARK 200  MONOCHROMATOR                  : SI(111)
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 2M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XSCALE
REMARK 200  DATA SCALING SOFTWARE          : SCALA
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 88070
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.850
REMARK 200  RESOLUTION RANGE LOW       (A) : 43.737
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.5
REMARK 200  DATA REDUNDANCY                : 3.400
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : 0.04100
REMARK 200   FOR THE DATA SET  : 17.9000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.85
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.95
REMARK 200  COMPLETENESS FOR SHELL     (%) : 99.6
REMARK 200  DATA REDUNDANCY IN SHELL       : 3.30
REMARK 200  R MERGE FOR SHELL          (I) : 0.30200
REMARK 200  R SYM FOR SHELL            (I) : 0.30200
REMARK 200   FOR SHELL         : 2.500
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: BALBES
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 44.73
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.23
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1 M CITRIC ACID PH 5.2 AND 18% PEG
REMARK 280  3350, VAPOR DIFFUSION, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       40.56250
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3, 4
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 3
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 4
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A   -19
REMARK 465     GLY A   -18
REMARK 465     SER A   -17
REMARK 465     SER A   -16
REMARK 465     HIS A   -15
REMARK 465     HIS A   -14
REMARK 465     HIS A   -13
REMARK 465     HIS A   -12
REMARK 465     HIS A   -11
REMARK 465     HIS A   -10
REMARK 465     SER A    -9
REMARK 465     SER A    -8
REMARK 465     GLY A    -7
REMARK 465     LEU A    -6
REMARK 465     VAL A    -5
REMARK 465     PRO A    -4
REMARK 465     ARG A    -3
REMARK 465     GLY A    -2
REMARK 465     SER A    -1
REMARK 465     HIS A     0
REMARK 465     MET A     1
REMARK 465     GLY A   250
REMARK 465     MET B   -19
REMARK 465     GLY B   -18
REMARK 465     SER B   -17
REMARK 465     SER B   -16
REMARK 465     HIS B   -15
REMARK 465     HIS B   -14
REMARK 465     HIS B   -13
REMARK 465     HIS B   -12
REMARK 465     HIS B   -11
REMARK 465     HIS B   -10
REMARK 465     SER B    -9
REMARK 465     SER B    -8
REMARK 465     GLY B    -7
REMARK 465     LEU B    -6
REMARK 465     VAL B    -5
REMARK 465     PRO B    -4
REMARK 465     ARG B    -3
REMARK 465     GLY B    -2
REMARK 465     SER B    -1
REMARK 465     HIS B     0
REMARK 465     MET B     1
REMARK 465     GLY B   250
REMARK 465     MET C   -19
REMARK 465     GLY C   -18
REMARK 465     SER C   -17
REMARK 465     SER C   -16
REMARK 465     HIS C   -15
REMARK 465     HIS C   -14
REMARK 465     HIS C   -13
REMARK 465     HIS C   -12
REMARK 465     HIS C   -11
REMARK 465     HIS C   -10
REMARK 465     SER C    -9
REMARK 465     SER C    -8
REMARK 465     GLY C    -7
REMARK 465     LEU C    -6
REMARK 465     VAL C    -5
REMARK 465     PRO C    -4
REMARK 465     ARG C    -3
REMARK 465     GLY C    -2
REMARK 465     SER C    -1
REMARK 465     HIS C     0
REMARK 465     MET C     1
REMARK 465     MET D   -19
REMARK 465     GLY D   -18
REMARK 465     SER D   -17
REMARK 465     SER D   -16
REMARK 465     HIS D   -15
REMARK 465     HIS D   -14
REMARK 465     HIS D   -13
REMARK 465     HIS D   -12
REMARK 465     HIS D   -11
REMARK 465     HIS D   -10
REMARK 465     SER D    -9
REMARK 465     SER D    -8
REMARK 465     GLY D    -7
REMARK 465     LEU D    -6
REMARK 465     VAL D    -5
REMARK 465     PRO D    -4
REMARK 465     ARG D    -3
REMARK 465     GLY D    -2
REMARK 465     SER D    -1
REMARK 465     HIS D     0
REMARK 465     MET D     1
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     LYS B 155    CG   CD   CE   NZ
REMARK 470     LYS D 155    CD   CE   NZ
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   ND1  HIS B    61     OE1  GLU B    63              2.09
REMARK 500   ND1  HIS A    61     OE1  GLU A    63              2.16
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    PRO B  20   C   -  N   -  CA  ANGL. DEV. =  10.3 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ASN A  18     -121.68   -132.60
REMARK 500    THR A  30       -1.04     67.76
REMARK 500    THR A  60      -83.93   -117.71
REMARK 500    SER A  97     -120.92     64.45
REMARK 500    GLU A 195       55.69   -110.60
REMARK 500    TYR A 225     -149.31   -102.86
REMARK 500    ASN B  18     -121.01   -139.15
REMARK 500    THR B  60      -78.95   -118.12
REMARK 500    SER B  97     -122.64     66.02
REMARK 500    GLU B 195       52.55   -113.05
REMARK 500    TYR B 225     -146.62   -101.74
REMARK 500    ASN C  18     -114.53   -131.44
REMARK 500    THR C  30       -3.41     69.85
REMARK 500    THR C  60      -73.85   -123.35
REMARK 500    SER C  97     -118.13     65.79
REMARK 500    TYR C 225     -149.26    -96.18
REMARK 500    ASN D  18     -118.86   -138.40
REMARK 500    THR D  30       -3.89     71.54
REMARK 500    THR D  60      -75.51   -118.12
REMARK 500    SER D  97     -119.27     64.57
REMARK 500    TYR D 225     -145.68    -94.66
REMARK 500
REMARK 500 REMARK: NULL
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE 1QY A 301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE 1QY B 301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE 1QY C 301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE 1QY D 301
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 4KE6   RELATED DB: PDB
REMARK 900 RELATED ID: 4KE7   RELATED DB: PDB
REMARK 900 RELATED ID: 4KE9   RELATED DB: PDB
REMARK 900 RELATED ID: 4KEA   RELATED DB: PDB
DBREF  4KE8 A    1   250  UNP    P82597   MGLP_BAC25       1    250
DBREF  4KE8 B    1   250  UNP    P82597   MGLP_BAC25       1    250
DBREF  4KE8 C    1   250  UNP    P82597   MGLP_BAC25       1    250
DBREF  4KE8 D    1   250  UNP    P82597   MGLP_BAC25       1    250
SEQADV 4KE8 MET A  -19  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 GLY A  -18  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 SER A  -17  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 SER A  -16  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS A  -15  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS A  -14  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS A  -13  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS A  -12  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS A  -11  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS A  -10  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 SER A   -9  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 SER A   -8  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 GLY A   -7  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 LEU A   -6  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 VAL A   -5  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 PRO A   -4  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 ARG A   -3  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 GLY A   -2  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 SER A   -1  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS A    0  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 MET B  -19  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 GLY B  -18  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 SER B  -17  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 SER B  -16  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS B  -15  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS B  -14  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS B  -13  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS B  -12  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS B  -11  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS B  -10  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 SER B   -9  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 SER B   -8  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 GLY B   -7  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 LEU B   -6  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 VAL B   -5  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 PRO B   -4  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 ARG B   -3  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 GLY B   -2  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 SER B   -1  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS B    0  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 MET C  -19  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 GLY C  -18  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 SER C  -17  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 SER C  -16  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS C  -15  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS C  -14  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS C  -13  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS C  -12  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS C  -11  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS C  -10  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 SER C   -9  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 SER C   -8  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 GLY C   -7  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 LEU C   -6  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 VAL C   -5  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 PRO C   -4  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 ARG C   -3  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 GLY C   -2  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 SER C   -1  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS C    0  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 MET D  -19  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 GLY D  -18  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 SER D  -17  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 SER D  -16  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS D  -15  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS D  -14  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS D  -13  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS D  -12  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS D  -11  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS D  -10  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 SER D   -9  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 SER D   -8  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 GLY D   -7  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 LEU D   -6  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 VAL D   -5  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 PRO D   -4  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 ARG D   -3  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 GLY D   -2  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 SER D   -1  UNP  P82597              EXPRESSION TAG
SEQADV 4KE8 HIS D    0  UNP  P82597              EXPRESSION TAG
SEQRES   1 A  270  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 A  270  LEU VAL PRO ARG GLY SER HIS MET SER GLU GLN TYR PRO
SEQRES   3 A  270  VAL LEU SER GLY ALA GLU PRO PHE TYR ALA GLU ASN GLY
SEQRES   4 A  270  PRO VAL GLY VAL LEU LEU VAL HIS GLY PHE THR GLY THR
SEQRES   5 A  270  PRO HIS SER MET ARG PRO LEU ALA GLU ALA TYR ALA LYS
SEQRES   6 A  270  ALA GLY TYR THR VAL CYS LEU PRO ARG LEU LYS GLY HIS
SEQRES   7 A  270  GLY THR HIS TYR GLU ASP MET GLU ARG THR THR PHE HIS
SEQRES   8 A  270  ASP TRP VAL ALA SER VAL GLU GLU GLY TYR GLY TRP LEU
SEQRES   9 A  270  LYS GLN ARG CYS GLN THR ILE PHE VAL THR GLY LEU SER
SEQRES  10 A  270  MET GLY GLY THR LEU THR LEU TYR LEU ALA GLU HIS HIS
SEQRES  11 A  270  PRO ASP ILE CYS GLY ILE VAL PRO ILE ASN ALA ALA VAL
SEQRES  12 A  270  ASP ILE PRO ALA ILE ALA ALA GLY MET THR GLY GLY GLY
SEQRES  13 A  270  GLU LEU PRO ARG TYR LEU ASP SER ILE GLY SER ASP LEU
SEQRES  14 A  270  LYS ASN PRO ASP VAL LYS GLU LEU ALA TYR GLU LYS THR
SEQRES  15 A  270  PRO THR ALA SER LEU LEU GLN LEU ALA ARG LEU MET ALA
SEQRES  16 A  270  GLN THR LYS ALA LYS LEU ASP ARG ILE VAL CYS PRO ALA
SEQRES  17 A  270  LEU ILE PHE VAL SER ASP GLU ASP HIS VAL VAL PRO PRO
SEQRES  18 A  270  GLY ASN ALA ASP ILE ILE PHE GLN GLY ILE SER SER THR
SEQRES  19 A  270  GLU LYS GLU ILE VAL ARG LEU ARG ASN SER TYR HIS VAL
SEQRES  20 A  270  ALA THR LEU ASP TYR ASP GLN PRO MET ILE ILE GLU ARG
SEQRES  21 A  270  SER LEU GLU PHE PHE ALA LYS HIS ALA GLY
SEQRES   1 B  270  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 B  270  LEU VAL PRO ARG GLY SER HIS MET SER GLU GLN TYR PRO
SEQRES   3 B  270  VAL LEU SER GLY ALA GLU PRO PHE TYR ALA GLU ASN GLY
SEQRES   4 B  270  PRO VAL GLY VAL LEU LEU VAL HIS GLY PHE THR GLY THR
SEQRES   5 B  270  PRO HIS SER MET ARG PRO LEU ALA GLU ALA TYR ALA LYS
SEQRES   6 B  270  ALA GLY TYR THR VAL CYS LEU PRO ARG LEU LYS GLY HIS
SEQRES   7 B  270  GLY THR HIS TYR GLU ASP MET GLU ARG THR THR PHE HIS
SEQRES   8 B  270  ASP TRP VAL ALA SER VAL GLU GLU GLY TYR GLY TRP LEU
SEQRES   9 B  270  LYS GLN ARG CYS GLN THR ILE PHE VAL THR GLY LEU SER
SEQRES  10 B  270  MET GLY GLY THR LEU THR LEU TYR LEU ALA GLU HIS HIS
SEQRES  11 B  270  PRO ASP ILE CYS GLY ILE VAL PRO ILE ASN ALA ALA VAL
SEQRES  12 B  270  ASP ILE PRO ALA ILE ALA ALA GLY MET THR GLY GLY GLY
SEQRES  13 B  270  GLU LEU PRO ARG TYR LEU ASP SER ILE GLY SER ASP LEU
SEQRES  14 B  270  LYS ASN PRO ASP VAL LYS GLU LEU ALA TYR GLU LYS THR
SEQRES  15 B  270  PRO THR ALA SER LEU LEU GLN LEU ALA ARG LEU MET ALA
SEQRES  16 B  270  GLN THR LYS ALA LYS LEU ASP ARG ILE VAL CYS PRO ALA
SEQRES  17 B  270  LEU ILE PHE VAL SER ASP GLU ASP HIS VAL VAL PRO PRO
SEQRES  18 B  270  GLY ASN ALA ASP ILE ILE PHE GLN GLY ILE SER SER THR
SEQRES  19 B  270  GLU LYS GLU ILE VAL ARG LEU ARG ASN SER TYR HIS VAL
SEQRES  20 B  270  ALA THR LEU ASP TYR ASP GLN PRO MET ILE ILE GLU ARG
SEQRES  21 B  270  SER LEU GLU PHE PHE ALA LYS HIS ALA GLY
SEQRES   1 C  270  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 C  270  LEU VAL PRO ARG GLY SER HIS MET SER GLU GLN TYR PRO
SEQRES   3 C  270  VAL LEU SER GLY ALA GLU PRO PHE TYR ALA GLU ASN GLY
SEQRES   4 C  270  PRO VAL GLY VAL LEU LEU VAL HIS GLY PHE THR GLY THR
SEQRES   5 C  270  PRO HIS SER MET ARG PRO LEU ALA GLU ALA TYR ALA LYS
SEQRES   6 C  270  ALA GLY TYR THR VAL CYS LEU PRO ARG LEU LYS GLY HIS
SEQRES   7 C  270  GLY THR HIS TYR GLU ASP MET GLU ARG THR THR PHE HIS
SEQRES   8 C  270  ASP TRP VAL ALA SER VAL GLU GLU GLY TYR GLY TRP LEU
SEQRES   9 C  270  LYS GLN ARG CYS GLN THR ILE PHE VAL THR GLY LEU SER
SEQRES  10 C  270  MET GLY GLY THR LEU THR LEU TYR LEU ALA GLU HIS HIS
SEQRES  11 C  270  PRO ASP ILE CYS GLY ILE VAL PRO ILE ASN ALA ALA VAL
SEQRES  12 C  270  ASP ILE PRO ALA ILE ALA ALA GLY MET THR GLY GLY GLY
SEQRES  13 C  270  GLU LEU PRO ARG TYR LEU ASP SER ILE GLY SER ASP LEU
SEQRES  14 C  270  LYS ASN PRO ASP VAL LYS GLU LEU ALA TYR GLU LYS THR
SEQRES  15 C  270  PRO THR ALA SER LEU LEU GLN LEU ALA ARG LEU MET ALA
SEQRES  16 C  270  GLN THR LYS ALA LYS LEU ASP ARG ILE VAL CYS PRO ALA
SEQRES  17 C  270  LEU ILE PHE VAL SER ASP GLU ASP HIS VAL VAL PRO PRO
SEQRES  18 C  270  GLY ASN ALA ASP ILE ILE PHE GLN GLY ILE SER SER THR
SEQRES  19 C  270  GLU LYS GLU ILE VAL ARG LEU ARG ASN SER TYR HIS VAL
SEQRES  20 C  270  ALA THR LEU ASP TYR ASP GLN PRO MET ILE ILE GLU ARG
SEQRES  21 C  270  SER LEU GLU PHE PHE ALA LYS HIS ALA GLY
SEQRES   1 D  270  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 D  270  LEU VAL PRO ARG GLY SER HIS MET SER GLU GLN TYR PRO
SEQRES   3 D  270  VAL LEU SER GLY ALA GLU PRO PHE TYR ALA GLU ASN GLY
SEQRES   4 D  270  PRO VAL GLY VAL LEU LEU VAL HIS GLY PHE THR GLY THR
SEQRES   5 D  270  PRO HIS SER MET ARG PRO LEU ALA GLU ALA TYR ALA LYS
SEQRES   6 D  270  ALA GLY TYR THR VAL CYS LEU PRO ARG LEU LYS GLY HIS
SEQRES   7 D  270  GLY THR HIS TYR GLU ASP MET GLU ARG THR THR PHE HIS
SEQRES   8 D  270  ASP TRP VAL ALA SER VAL GLU GLU GLY TYR GLY TRP LEU
SEQRES   9 D  270  LYS GLN ARG CYS GLN THR ILE PHE VAL THR GLY LEU SER
SEQRES  10 D  270  MET GLY GLY THR LEU THR LEU TYR LEU ALA GLU HIS HIS
SEQRES  11 D  270  PRO ASP ILE CYS GLY ILE VAL PRO ILE ASN ALA ALA VAL
SEQRES  12 D  270  ASP ILE PRO ALA ILE ALA ALA GLY MET THR GLY GLY GLY
SEQRES  13 D  270  GLU LEU PRO ARG TYR LEU ASP SER ILE GLY SER ASP LEU
SEQRES  14 D  270  LYS ASN PRO ASP VAL LYS GLU LEU ALA TYR GLU LYS THR
SEQRES  15 D  270  PRO THR ALA SER LEU LEU GLN LEU ALA ARG LEU MET ALA
SEQRES  16 D  270  GLN THR LYS ALA LYS LEU ASP ARG ILE VAL CYS PRO ALA
SEQRES  17 D  270  LEU ILE PHE VAL SER ASP GLU ASP HIS VAL VAL PRO PRO
SEQRES  18 D  270  GLY ASN ALA ASP ILE ILE PHE GLN GLY ILE SER SER THR
SEQRES  19 D  270  GLU LYS GLU ILE VAL ARG LEU ARG ASN SER TYR HIS VAL
SEQRES  20 D  270  ALA THR LEU ASP TYR ASP GLN PRO MET ILE ILE GLU ARG
SEQRES  21 D  270  SER LEU GLU PHE PHE ALA LYS HIS ALA GLY
HET    1QY  A 301      23
HET    1QY  B 301      23
HET    1QY  C 301      23
HET    1QY  D 301      23
HETNAM     1QY TETRADECYL HYDROGEN (R)-(3-AZIDOPROPYL)PHOSPHONATE
FORMUL   5  1QY    4(C17 H36 N3 O3 P)
FORMUL   9  HOH   *902(H2 O)
HELIX    1   1 THR A   32  SER A   35  5                                   4
HELIX    2   2 MET A   36  ALA A   46  1                                  11
HELIX    3   3 HIS A   61  ARG A   67  1                                   7
HELIX    4   4 THR A   69  GLN A   86  1                                  18
HELIX    5   5 SER A   97  HIS A  110  1                                  14
HELIX    6   6 ILE A  125  THR A  133  1                                   9
HELIX    7   7 THR A  164  LYS A  180  1                                  17
HELIX    8   8 LEU A  181  ILE A  184  5                                   4
HELIX    9   9 GLY A  202  ILE A  211  1                                  10
HELIX   10  10 VAL A  227  ASP A  231  5                                   5
HELIX   11  11 ASP A  233  ALA A  249  1                                  17
HELIX   12  12 THR B   32  SER B   35  5                                   4
HELIX   13  13 MET B   36  ALA B   46  1                                  11
HELIX   14  14 HIS B   61  ARG B   67  1                                   7
HELIX   15  15 THR B   69  CYS B   88  1                                  20
HELIX   16  16 SER B   97  HIS B  110  1                                  14
HELIX   17  17 ILE B  125  THR B  133  1                                   9
HELIX   18  18 THR B  164  LYS B  180  1                                  17
HELIX   19  19 LEU B  181  ILE B  184  5                                   4
HELIX   20  20 GLY B  202  ILE B  211  1                                  10
HELIX   21  21 ASP B  233  ALA B  249  1                                  17
HELIX   22  22 THR C   32  SER C   35  5                                   4
HELIX   23  23 MET C   36  ALA C   46  1                                  11
HELIX   24  24 HIS C   61  THR C   68  1                                   8
HELIX   25  25 THR C   69  GLN C   86  1                                  18
HELIX   26  26 SER C   97  HIS C  110  1                                  14
HELIX   27  27 ILE C  125  THR C  133  1                                   9
HELIX   28  28 THR C  164  LYS C  180  1                                  17
HELIX   29  29 LEU C  181  ILE C  184  5                                   4
HELIX   30  30 GLY C  202  ILE C  211  1                                  10
HELIX   31  31 ASP C  233  GLY C  250  1                                  18
HELIX   32  32 THR D   32  SER D   35  5                                   4
HELIX   33  33 MET D   36  ALA D   46  1                                  11
HELIX   34  34 HIS D   61  THR D   68  1                                   8
HELIX   35  35 THR D   69  GLN D   86  1                                  18
HELIX   36  36 SER D   97  HIS D  110  1                                  14
HELIX   37  37 ILE D  125  THR D  133  1                                   9
HELIX   38  38 THR D  164  LYS D  180  1                                  17
HELIX   39  39 LEU D  181  ILE D  184  5                                   4
HELIX   40  40 GLY D  202  ILE D  211  1                                  10
HELIX   41  41 ASP D  233  GLY D  250  1                                  18
SHEET    1   A 5 PHE A  14  ALA A  16  0
SHEET    2   A 5 THR A  49  LEU A  52 -1  O  LEU A  52   N  PHE A  14
SHEET    3   A 5 VAL A  21  VAL A  26  1  N  LEU A  25   O  CYS A  51
SHEET    4   A 5 THR A  90  LEU A  96  1  O  THR A  90   N  GLY A  22
SHEET    5   A 5 GLY A 115  ILE A 119  1  O  ILE A 119   N  GLY A  95
SHEET    1   B 2 TYR A 141  ASP A 143  0
SHEET    2   B 2 LYS A 161  PRO A 163 -1  O  THR A 162   N  LEU A 142
SHEET    1   C 2 ALA A 188  SER A 193  0
SHEET    2   C 2 LYS A 216  LEU A 221  1  O  LEU A 221   N  VAL A 192
SHEET    1   D 5 PHE B  14  ALA B  16  0
SHEET    2   D 5 THR B  49  LEU B  52 -1  O  LEU B  52   N  PHE B  14
SHEET    3   D 5 VAL B  21  VAL B  26  1  N  LEU B  25   O  CYS B  51
SHEET    4   D 5 THR B  90  LEU B  96  1  O  THR B  90   N  GLY B  22
SHEET    5   D 5 GLY B 115  ILE B 119  1  O  ILE B 119   N  GLY B  95
SHEET    1   E 2 TYR B 141  ASP B 143  0
SHEET    2   E 2 LYS B 161  PRO B 163 -1  O  THR B 162   N  LEU B 142
SHEET    1   F 2 ALA B 188  SER B 193  0
SHEET    2   F 2 LYS B 216  LEU B 221  1  O  GLU B 217   N  ILE B 190
SHEET    1   G 5 PHE C  14  ALA C  16  0
SHEET    2   G 5 THR C  49  LEU C  52 -1  O  LEU C  52   N  PHE C  14
SHEET    3   G 5 VAL C  21  VAL C  26  1  N  LEU C  25   O  CYS C  51
SHEET    4   G 5 THR C  90  LEU C  96  1  O  THR C  90   N  GLY C  22
SHEET    5   G 5 GLY C 115  ILE C 119  1  O  ILE C 119   N  GLY C  95
SHEET    1   H 2 TYR C 141  ASP C 143  0
SHEET    2   H 2 LYS C 161  PRO C 163 -1  O  THR C 162   N  LEU C 142
SHEET    1   I 2 ALA C 188  SER C 193  0
SHEET    2   I 2 LYS C 216  LEU C 221  1  O  LEU C 221   N  VAL C 192
SHEET    1   J 5 PHE D  14  ALA D  16  0
SHEET    2   J 5 THR D  49  LEU D  52 -1  O  LEU D  52   N  PHE D  14
SHEET    3   J 5 VAL D  21  VAL D  26  1  N  LEU D  25   O  CYS D  51
SHEET    4   J 5 THR D  90  LEU D  96  1  O  THR D  90   N  GLY D  22
SHEET    5   J 5 GLY D 115  ILE D 119  1  O  ILE D 119   N  GLY D  95
SHEET    1   K 2 TYR D 141  ASP D 143  0
SHEET    2   K 2 LYS D 161  PRO D 163 -1  O  THR D 162   N  LEU D 142
SHEET    1   L 2 ALA D 188  SER D 193  0
SHEET    2   L 2 LYS D 216  LEU D 221  1  O  LEU D 221   N  VAL D 192
LINK         OG  SER A  97                 P1  1QY A 301     1555   1555  1.62
LINK         OG  SER D  97                 P1  1QY D 301     1555   1555  1.58
LINK         OG  SER B  97                 P1  1QY B 301     1555   1555  1.62
LINK         OG  SER C  97                 P1  1QY C 301     1555   1555  1.66
SITE     1 AC1 13 GLY A  28  PHE A  29  SER A  97  MET A  98
SITE     2 AC1 13 ALA A 127  ILE A 128  GLY A 131  LEU A 142
SITE     3 AC1 13 LEU A 170  VAL A 198  HIS A 226  HOH A 548
SITE     4 AC1 13 HOH A 604
SITE     1 AC2 14 GLY B  28  PHE B  29  GLY B  31  SER B  97
SITE     2 AC2 14 MET B  98  ILE B 125  ALA B 127  GLY B 131
SITE     3 AC2 14 LEU B 138  LEU B 142  GLU B 156  VAL B 198
SITE     4 AC2 14 HIS B 226  HOH B 515
SITE     1 AC3 17 GLY C  28  PHE C  29  SER C  97  MET C  98
SITE     2 AC3 17 ALA C 127  ILE C 128  MET C 132  LEU C 142
SITE     3 AC3 17 ILE C 145  GLY C 146  SER C 147  ASP C 148
SITE     4 AC3 17 GLU C 156  VAL C 198  VAL C 199  HIS C 226
SITE     5 AC3 17 VAL C 227
SITE     1 AC4 18 LEU B 168  GLY D  28  PHE D  29  SER D  97
SITE     2 AC4 18 MET D  98  ILE D 125  ALA D 127  ILE D 128
SITE     3 AC4 18 LEU D 142  ILE D 145  GLY D 146  SER D 147
SITE     4 AC4 18 ASP D 148  GLU D 156  LEU D 170  VAL D 198
SITE     5 AC4 18 HIS D 226  VAL D 227
CRYST1   77.015   81.125   85.611  90.00 100.26  90.00 P 1 21 1      8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.012984  0.000000  0.002350        0.00000
SCALE2      0.000000  0.012327  0.000000        0.00000
SCALE3      0.000000  0.000000  0.011871        0.00000
TER    1913      ALA A 249
TER    3827      ALA B 249
TER    5753      GLY C 250
TER    7668      GLY D 250
MASTER      414    0    4   41   36    0   18    6 8645    4   96   84
END