longtext: 4KE9-pdb

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HEADER    HYDROLASE                               25-APR-13   4KE9
TITLE     CRYSTAL STRUCTURE OF MONOGLYCERIDE LIPASE FROM BACILLUS SP. H257 IN
TITLE    2 COMPLEX WITH AN 1-STEARYOL GLYCEROL ANALOGUE
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: THERMOSTABLE MONOACYLGLYCEROL LIPASE;
COMPND   3 CHAIN: A, B, C, D;
COMPND   4 SYNONYM: MGLP;
COMPND   5 EC: 3.1.1.23;
COMPND   6 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: BACILLUS SP.;
SOURCE   3 ORGANISM_TAXID: 129908;
SOURCE   4 STRAIN: H-257;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE   7 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);
SOURCE   8 EXPRESSION_SYSTEM_VECTOR_TYPE: PET28A(+)
KEYWDS    ALPHA/BETA HYDROLASE FOLD, MONOGLYCERIDE LIPASE, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    S.RENGACHARI,P.ASCHAUER,K.GRUBER,I.DREVENY,M.OBERER
REVDAT   1   18-SEP-13 4KE9    0
JRNL        AUTH   S.RENGACHARI,P.ASCHAUER,K.GRUBER,I.DREVENY,M.OBERER
JRNL        TITL   CONFORMATIONAL PLASTICITY AND LIGAND BINDING OF BACTERIAL
JRNL        TITL 2 MONOACYLGLYCEROL LIPASE
JRNL        REF    J.BIOL.CHEM.                               2013
JRNL        REFN                   ESSN 1083-351X
REMARK   2
REMARK   2 RESOLUTION.    2.20 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX (PHENIX.REFINE: 1.8.2_1309)
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VICENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-
REMARK   3               : KUNSTLEVE,LI-WEI HUNG,ROBERT IMMORMINO,
REMARK   3               : TOM IOERGER,AIRLIE MCCOY,ERIK MCKEE,NIGEL
REMARK   3               : MORIARTY,REETAL PAI,RANDY READ,JANE
REMARK   3               : RICHARDSON,DAVID RICHARDSON,TOD ROMO,JIM
REMARK   3               : SACCHETTINI,NICHOLAS SAUTER,JACOB SMITH,
REMARK   3               : LAURENT STORONI,TOM TERWILLIGER,PETER
REMARK   3               : ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : ML
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.20
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 43.66
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.390
REMARK   3   COMPLETENESS FOR RANGE        (%) : 92.5
REMARK   3   NUMBER OF REFLECTIONS             : 48678
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.225
REMARK   3   R VALUE            (WORKING SET) : 0.223
REMARK   3   FREE R VALUE                     : 0.262
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.130
REMARK   3   FREE R VALUE TEST SET COUNT      : 2492
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 43.6695 -  6.8276    0.94     3074   151  0.1974 0.2093
REMARK   3     2  6.8276 -  5.4225    1.00     3263   149  0.2112 0.2139
REMARK   3     3  5.4225 -  4.7380    1.00     3241   165  0.2013 0.2127
REMARK   3     4  4.7380 -  4.3052    1.00     3212   195  0.1833 0.2268
REMARK   3     5  4.3052 -  3.9969    1.00     3248   160  0.1950 0.2521
REMARK   3     6  3.9969 -  3.7614    1.00     3244   185  0.2008 0.1984
REMARK   3     7  3.7614 -  3.5731    1.00     3227   167  0.2173 0.2596
REMARK   3     8  3.5731 -  3.4176    1.00     3277   162  0.2245 0.2716
REMARK   3     9  3.4176 -  3.2861    1.00     3192   202  0.2319 0.2526
REMARK   3    10  3.2861 -  3.1727    1.00     3212   184  0.2427 0.2938
REMARK   3    11  3.1727 -  3.0736    1.00     3190   201  0.2357 0.2733
REMARK   3    12  3.0736 -  2.9857    1.00     3262   183  0.2416 0.3150
REMARK   3    13  2.9857 -  2.9071    1.00     3244   202  0.2382 0.3058
REMARK   3    14  2.9071 -  2.8362    1.00     3198   191  0.2330 0.2549
REMARK   3    15  2.8362 -  2.7718    1.00     3244   159  0.2261 0.2674
REMARK   3    16  2.7718 -  2.7128    1.00     3258   175  0.2220 0.2856
REMARK   3    17  2.7128 -  2.6585    1.00     3202   176  0.2221 0.2432
REMARK   3    18  2.6585 -  2.6084    1.00     3273   154  0.2224 0.2928
REMARK   3    19  2.6084 -  2.5618    1.00     3243   188  0.2246 0.2907
REMARK   3    20  2.5618 -  2.5184    1.00     3224   149  0.2251 0.2574
REMARK   3    21  2.5184 -  2.4777    0.99     3237   166  0.2289 0.2959
REMARK   3    22  2.4777 -  2.4396    0.95     3060   165  0.2379 0.2577
REMARK   3    23  2.4396 -  2.4038    0.90     2951   125  0.2371 0.2797
REMARK   3    24  2.4038 -  2.3699    0.85     2783   154  0.2349 0.3383
REMARK   3    25  2.3699 -  2.3379    0.79     2524   134  0.2339 0.2675
REMARK   3    26  2.3379 -  2.3075    0.75     2397   153  0.2314 0.3314
REMARK   3    27  2.3075 -  2.2787    0.70     2304   107  0.2422 0.3294
REMARK   3    28  2.2787 -  2.2512    0.67     2149   133  0.3003 0.3771
REMARK   3    29  2.2512 -  2.2250    0.62     1990   123  0.4385 0.4921
REMARK   3    30  2.2250 -  2.2000    0.60     1966    99  0.3340 0.3956
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.260
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 32.150
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -10.46400
REMARK   3    B22 (A**2) : 20.73080
REMARK   3    B33 (A**2) : -10.26690
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 1.00790
REMARK   3    B23 (A**2) : -0.00000
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.003           7907
REMARK   3   ANGLE     :  0.840          10740
REMARK   3   CHIRALITY :  0.043           1191
REMARK   3   PLANARITY :  0.004           1378
REMARK   3   DIHEDRAL  : 12.586           2836
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 4KE9 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 02-MAY-13.
REMARK 100 THE RCSB ID CODE IS RCSB079228.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 25-JUN-12
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 5.0
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : ESRF
REMARK 200  BEAMLINE                       : ID14-4
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.98
REMARK 200  MONOCHROMATOR                  : CHANNEL-CUT MONOCHROMATOR
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 315R
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XSCALE
REMARK 200  DATA SCALING SOFTWARE          : SCALA
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 48702
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.200
REMARK 200  RESOLUTION RANGE LOW       (A) : 43.661
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 93.2
REMARK 200  DATA REDUNDANCY                : 7.000
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : 0.13900
REMARK 200   FOR THE DATA SET  : 9.0000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.20
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.32
REMARK 200  COMPLETENESS FOR SHELL     (%) : 68.4
REMARK 200  DATA REDUNDANCY IN SHELL       : 4.80
REMARK 200  R MERGE FOR SHELL          (I) : 0.55700
REMARK 200  R SYM FOR SHELL            (I) : 0.55700
REMARK 200   FOR SHELL         : 0.900
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 44.56
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.22
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1 M CITRIC ACID PH 5.0 AND 22% PEG
REMARK 280  3350, VAPOR DIFFUSION, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       40.14350
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3, 4
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 3
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 4
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A   -17
REMARK 465     GLY A   -16
REMARK 465     SER A   -15
REMARK 465     SER A   -14
REMARK 465     HIS A   -13
REMARK 465     HIS A   -12
REMARK 465     HIS A   -11
REMARK 465     HIS A   -10
REMARK 465     HIS A    -9
REMARK 465     HIS A    -8
REMARK 465     SER A    -7
REMARK 465     SER A    -6
REMARK 465     GLY A    -5
REMARK 465     LEU A    -4
REMARK 465     VAL A    -3
REMARK 465     PRO A    -2
REMARK 465     ARG A    -1
REMARK 465     GLY A     0
REMARK 465     SER A     1
REMARK 465     HIS A     2
REMARK 465     GLY A   250
REMARK 465     MET B   -17
REMARK 465     GLY B   -16
REMARK 465     SER B   -15
REMARK 465     SER B   -14
REMARK 465     HIS B   -13
REMARK 465     HIS B   -12
REMARK 465     HIS B   -11
REMARK 465     HIS B   -10
REMARK 465     HIS B    -9
REMARK 465     HIS B    -8
REMARK 465     SER B    -7
REMARK 465     SER B    -6
REMARK 465     GLY B    -5
REMARK 465     LEU B    -4
REMARK 465     VAL B    -3
REMARK 465     PRO B    -2
REMARK 465     ARG B    -1
REMARK 465     GLY B     0
REMARK 465     SER B     1
REMARK 465     HIS B     2
REMARK 465     GLY B   250
REMARK 465     MET C   -17
REMARK 465     GLY C   -16
REMARK 465     SER C   -15
REMARK 465     SER C   -14
REMARK 465     HIS C   -13
REMARK 465     HIS C   -12
REMARK 465     HIS C   -11
REMARK 465     HIS C   -10
REMARK 465     HIS C    -9
REMARK 465     HIS C    -8
REMARK 465     SER C    -7
REMARK 465     SER C    -6
REMARK 465     GLY C    -5
REMARK 465     LEU C    -4
REMARK 465     VAL C    -3
REMARK 465     PRO C    -2
REMARK 465     ARG C    -1
REMARK 465     GLY C     0
REMARK 465     SER C     1
REMARK 465     HIS C     2
REMARK 465     GLU C     3
REMARK 465     GLY C   250
REMARK 465     MET D   -17
REMARK 465     GLY D   -16
REMARK 465     SER D   -15
REMARK 465     SER D   -14
REMARK 465     HIS D   -13
REMARK 465     HIS D   -12
REMARK 465     HIS D   -11
REMARK 465     HIS D   -10
REMARK 465     HIS D    -9
REMARK 465     HIS D    -8
REMARK 465     SER D    -7
REMARK 465     SER D    -6
REMARK 465     GLY D    -5
REMARK 465     LEU D    -4
REMARK 465     VAL D    -3
REMARK 465     PRO D    -2
REMARK 465     ARG D    -1
REMARK 465     GLY D     0
REMARK 465     SER D     1
REMARK 465     HIS D     2
REMARK 465     GLY D   250
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ASN A  18     -111.68   -118.62
REMARK 500    THR A  30       -5.63     65.31
REMARK 500    THR A  60      -84.91   -119.87
REMARK 500    ARG A  87       16.24   -152.73
REMARK 500    SER A  97     -114.15     60.22
REMARK 500    GLU A 195       63.22   -106.69
REMARK 500    TYR A 225     -145.68    -89.89
REMARK 500    ASN B  18     -121.78   -125.39
REMARK 500    THR B  30       -7.56     69.07
REMARK 500    THR B  60      -81.31   -118.07
REMARK 500    SER B  97     -116.65     60.03
REMARK 500    GLU B 195       60.81   -108.38
REMARK 500    TYR B 225     -144.54    -95.38
REMARK 500    ASN C  18     -114.11   -123.77
REMARK 500    THR C  60      -73.86   -130.08
REMARK 500    ARG C  87       12.03   -149.85
REMARK 500    SER C  97     -109.34     62.06
REMARK 500    GLU C 195       64.49   -103.66
REMARK 500    TYR C 225     -144.51    -92.43
REMARK 500    ASN D  18     -114.76   -126.97
REMARK 500    THR D  30       -1.12     63.19
REMARK 500    THR D  60      -73.47   -124.29
REMARK 500    SER D  97     -120.32     58.76
REMARK 500    TYR D 225     -141.39    -92.47
REMARK 500
REMARK 500 REMARK: NULL
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE 1R1 A 301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE 1R1 B 301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE 1R1 C 301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE 1R1 D 301
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 4KE6   RELATED DB: PDB
REMARK 900 RELATED ID: 4KE7   RELATED DB: PDB
REMARK 900 RELATED ID: 4KE8   RELATED DB: PDB
REMARK 900 RELATED ID: 4KEA   RELATED DB: PDB
DBREF  4KE9 A  -17   250  UNP    P82597   MGLP_BAC25       1    250
DBREF  4KE9 B  -17   250  UNP    P82597   MGLP_BAC25       1    250
DBREF  4KE9 C  -17   250  UNP    P82597   MGLP_BAC25       1    250
DBREF  4KE9 D  -17   250  UNP    P82597   MGLP_BAC25       1    250
SEQADV 4KE9 GLY A  -16  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 SER A  -15  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 SER A  -14  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS A  -13  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS A  -12  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS A  -11  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS A  -10  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS A   -9  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS A   -8  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 SER A   -7  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 SER A   -6  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 GLY A   -5  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 LEU A   -4  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 VAL A   -3  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 PRO A   -2  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 ARG A   -1  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 GLY A    0  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS A    2  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 GLY B  -16  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 SER B  -15  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 SER B  -14  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS B  -13  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS B  -12  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS B  -11  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS B  -10  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS B   -9  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS B   -8  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 SER B   -7  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 SER B   -6  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 GLY B   -5  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 LEU B   -4  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 VAL B   -3  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 PRO B   -2  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 ARG B   -1  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 GLY B    0  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS B    2  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 GLY C  -16  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 SER C  -15  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 SER C  -14  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS C  -13  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS C  -12  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS C  -11  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS C  -10  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS C   -9  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS C   -8  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 SER C   -7  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 SER C   -6  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 GLY C   -5  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 LEU C   -4  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 VAL C   -3  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 PRO C   -2  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 ARG C   -1  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 GLY C    0  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS C    2  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 GLY D  -16  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 SER D  -15  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 SER D  -14  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS D  -13  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS D  -12  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS D  -11  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS D  -10  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS D   -9  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS D   -8  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 SER D   -7  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 SER D   -6  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 GLY D   -5  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 LEU D   -4  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 VAL D   -3  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 PRO D   -2  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 ARG D   -1  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 GLY D    0  UNP  P82597              EXPRESSION TAG
SEQADV 4KE9 HIS D    2  UNP  P82597              EXPRESSION TAG
SEQRES   1 A  268  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 A  268  LEU VAL PRO ARG GLY SER HIS GLU GLN TYR PRO VAL LEU
SEQRES   3 A  268  SER GLY ALA GLU PRO PHE TYR ALA GLU ASN GLY PRO VAL
SEQRES   4 A  268  GLY VAL LEU LEU VAL HIS GLY PHE THR GLY THR PRO HIS
SEQRES   5 A  268  SER MET ARG PRO LEU ALA GLU ALA TYR ALA LYS ALA GLY
SEQRES   6 A  268  TYR THR VAL CYS LEU PRO ARG LEU LYS GLY HIS GLY THR
SEQRES   7 A  268  HIS TYR GLU ASP MET GLU ARG THR THR PHE HIS ASP TRP
SEQRES   8 A  268  VAL ALA SER VAL GLU GLU GLY TYR GLY TRP LEU LYS GLN
SEQRES   9 A  268  ARG CYS GLN THR ILE PHE VAL THR GLY LEU SER MET GLY
SEQRES  10 A  268  GLY THR LEU THR LEU TYR LEU ALA GLU HIS HIS PRO ASP
SEQRES  11 A  268  ILE CYS GLY ILE VAL PRO ILE ASN ALA ALA VAL ASP ILE
SEQRES  12 A  268  PRO ALA ILE ALA ALA GLY MET THR GLY GLY GLY GLU LEU
SEQRES  13 A  268  PRO ARG TYR LEU ASP SER ILE GLY SER ASP LEU LYS ASN
SEQRES  14 A  268  PRO ASP VAL LYS GLU LEU ALA TYR GLU LYS THR PRO THR
SEQRES  15 A  268  ALA SER LEU LEU GLN LEU ALA ARG LEU MET ALA GLN THR
SEQRES  16 A  268  LYS ALA LYS LEU ASP ARG ILE VAL CYS PRO ALA LEU ILE
SEQRES  17 A  268  PHE VAL SER ASP GLU ASP HIS VAL VAL PRO PRO GLY ASN
SEQRES  18 A  268  ALA ASP ILE ILE PHE GLN GLY ILE SER SER THR GLU LYS
SEQRES  19 A  268  GLU ILE VAL ARG LEU ARG ASN SER TYR HIS VAL ALA THR
SEQRES  20 A  268  LEU ASP TYR ASP GLN PRO MET ILE ILE GLU ARG SER LEU
SEQRES  21 A  268  GLU PHE PHE ALA LYS HIS ALA GLY
SEQRES   1 B  268  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 B  268  LEU VAL PRO ARG GLY SER HIS GLU GLN TYR PRO VAL LEU
SEQRES   3 B  268  SER GLY ALA GLU PRO PHE TYR ALA GLU ASN GLY PRO VAL
SEQRES   4 B  268  GLY VAL LEU LEU VAL HIS GLY PHE THR GLY THR PRO HIS
SEQRES   5 B  268  SER MET ARG PRO LEU ALA GLU ALA TYR ALA LYS ALA GLY
SEQRES   6 B  268  TYR THR VAL CYS LEU PRO ARG LEU LYS GLY HIS GLY THR
SEQRES   7 B  268  HIS TYR GLU ASP MET GLU ARG THR THR PHE HIS ASP TRP
SEQRES   8 B  268  VAL ALA SER VAL GLU GLU GLY TYR GLY TRP LEU LYS GLN
SEQRES   9 B  268  ARG CYS GLN THR ILE PHE VAL THR GLY LEU SER MET GLY
SEQRES  10 B  268  GLY THR LEU THR LEU TYR LEU ALA GLU HIS HIS PRO ASP
SEQRES  11 B  268  ILE CYS GLY ILE VAL PRO ILE ASN ALA ALA VAL ASP ILE
SEQRES  12 B  268  PRO ALA ILE ALA ALA GLY MET THR GLY GLY GLY GLU LEU
SEQRES  13 B  268  PRO ARG TYR LEU ASP SER ILE GLY SER ASP LEU LYS ASN
SEQRES  14 B  268  PRO ASP VAL LYS GLU LEU ALA TYR GLU LYS THR PRO THR
SEQRES  15 B  268  ALA SER LEU LEU GLN LEU ALA ARG LEU MET ALA GLN THR
SEQRES  16 B  268  LYS ALA LYS LEU ASP ARG ILE VAL CYS PRO ALA LEU ILE
SEQRES  17 B  268  PHE VAL SER ASP GLU ASP HIS VAL VAL PRO PRO GLY ASN
SEQRES  18 B  268  ALA ASP ILE ILE PHE GLN GLY ILE SER SER THR GLU LYS
SEQRES  19 B  268  GLU ILE VAL ARG LEU ARG ASN SER TYR HIS VAL ALA THR
SEQRES  20 B  268  LEU ASP TYR ASP GLN PRO MET ILE ILE GLU ARG SER LEU
SEQRES  21 B  268  GLU PHE PHE ALA LYS HIS ALA GLY
SEQRES   1 C  268  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 C  268  LEU VAL PRO ARG GLY SER HIS GLU GLN TYR PRO VAL LEU
SEQRES   3 C  268  SER GLY ALA GLU PRO PHE TYR ALA GLU ASN GLY PRO VAL
SEQRES   4 C  268  GLY VAL LEU LEU VAL HIS GLY PHE THR GLY THR PRO HIS
SEQRES   5 C  268  SER MET ARG PRO LEU ALA GLU ALA TYR ALA LYS ALA GLY
SEQRES   6 C  268  TYR THR VAL CYS LEU PRO ARG LEU LYS GLY HIS GLY THR
SEQRES   7 C  268  HIS TYR GLU ASP MET GLU ARG THR THR PHE HIS ASP TRP
SEQRES   8 C  268  VAL ALA SER VAL GLU GLU GLY TYR GLY TRP LEU LYS GLN
SEQRES   9 C  268  ARG CYS GLN THR ILE PHE VAL THR GLY LEU SER MET GLY
SEQRES  10 C  268  GLY THR LEU THR LEU TYR LEU ALA GLU HIS HIS PRO ASP
SEQRES  11 C  268  ILE CYS GLY ILE VAL PRO ILE ASN ALA ALA VAL ASP ILE
SEQRES  12 C  268  PRO ALA ILE ALA ALA GLY MET THR GLY GLY GLY GLU LEU
SEQRES  13 C  268  PRO ARG TYR LEU ASP SER ILE GLY SER ASP LEU LYS ASN
SEQRES  14 C  268  PRO ASP VAL LYS GLU LEU ALA TYR GLU LYS THR PRO THR
SEQRES  15 C  268  ALA SER LEU LEU GLN LEU ALA ARG LEU MET ALA GLN THR
SEQRES  16 C  268  LYS ALA LYS LEU ASP ARG ILE VAL CYS PRO ALA LEU ILE
SEQRES  17 C  268  PHE VAL SER ASP GLU ASP HIS VAL VAL PRO PRO GLY ASN
SEQRES  18 C  268  ALA ASP ILE ILE PHE GLN GLY ILE SER SER THR GLU LYS
SEQRES  19 C  268  GLU ILE VAL ARG LEU ARG ASN SER TYR HIS VAL ALA THR
SEQRES  20 C  268  LEU ASP TYR ASP GLN PRO MET ILE ILE GLU ARG SER LEU
SEQRES  21 C  268  GLU PHE PHE ALA LYS HIS ALA GLY
SEQRES   1 D  268  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 D  268  LEU VAL PRO ARG GLY SER HIS GLU GLN TYR PRO VAL LEU
SEQRES   3 D  268  SER GLY ALA GLU PRO PHE TYR ALA GLU ASN GLY PRO VAL
SEQRES   4 D  268  GLY VAL LEU LEU VAL HIS GLY PHE THR GLY THR PRO HIS
SEQRES   5 D  268  SER MET ARG PRO LEU ALA GLU ALA TYR ALA LYS ALA GLY
SEQRES   6 D  268  TYR THR VAL CYS LEU PRO ARG LEU LYS GLY HIS GLY THR
SEQRES   7 D  268  HIS TYR GLU ASP MET GLU ARG THR THR PHE HIS ASP TRP
SEQRES   8 D  268  VAL ALA SER VAL GLU GLU GLY TYR GLY TRP LEU LYS GLN
SEQRES   9 D  268  ARG CYS GLN THR ILE PHE VAL THR GLY LEU SER MET GLY
SEQRES  10 D  268  GLY THR LEU THR LEU TYR LEU ALA GLU HIS HIS PRO ASP
SEQRES  11 D  268  ILE CYS GLY ILE VAL PRO ILE ASN ALA ALA VAL ASP ILE
SEQRES  12 D  268  PRO ALA ILE ALA ALA GLY MET THR GLY GLY GLY GLU LEU
SEQRES  13 D  268  PRO ARG TYR LEU ASP SER ILE GLY SER ASP LEU LYS ASN
SEQRES  14 D  268  PRO ASP VAL LYS GLU LEU ALA TYR GLU LYS THR PRO THR
SEQRES  15 D  268  ALA SER LEU LEU GLN LEU ALA ARG LEU MET ALA GLN THR
SEQRES  16 D  268  LYS ALA LYS LEU ASP ARG ILE VAL CYS PRO ALA LEU ILE
SEQRES  17 D  268  PHE VAL SER ASP GLU ASP HIS VAL VAL PRO PRO GLY ASN
SEQRES  18 D  268  ALA ASP ILE ILE PHE GLN GLY ILE SER SER THR GLU LYS
SEQRES  19 D  268  GLU ILE VAL ARG LEU ARG ASN SER TYR HIS VAL ALA THR
SEQRES  20 D  268  LEU ASP TYR ASP GLN PRO MET ILE ILE GLU ARG SER LEU
SEQRES  21 D  268  GLU PHE PHE ALA LYS HIS ALA GLY
HET    1R1  A 301      25
HET    1R1  B 301      25
HET    1R1  C 301      25
HET    1R1  D 301      25
HETNAM     1R1 HEXADECYL HYDROGEN (R)-(3-AZIDOPROPYL)PHOSPHONATE
FORMUL   5  1R1    4(C19 H40 N3 O3 P)
FORMUL   9  HOH   *303(H2 O)
HELIX    1   1 THR A   32  SER A   35  5                                   4
HELIX    2   2 MET A   36  ALA A   46  1                                  11
HELIX    3   3 HIS A   61  GLU A   66  1                                   6
HELIX    4   4 THR A   69  GLN A   86  1                                  18
HELIX    5   5 SER A   97  GLU A  108  1                                  12
HELIX    6   6 ILE A  125  MET A  132  1                                   8
HELIX    7   7 THR A  164  LYS A  180  1                                  17
HELIX    8   8 LEU A  181  ILE A  184  5                                   4
HELIX    9   9 GLY A  202  ILE A  211  1                                  10
HELIX   10  10 ASP A  233  ALA A  249  1                                  17
HELIX   11  11 THR B   32  SER B   35  5                                   4
HELIX   12  12 MET B   36  ALA B   46  1                                  11
HELIX   13  13 HIS B   61  GLU B   66  1                                   6
HELIX   14  14 THR B   69  GLN B   86  1                                  18
HELIX   15  15 SER B   97  HIS B  110  1                                  14
HELIX   16  16 ILE B  125  THR B  133  1                                   9
HELIX   17  17 THR B  164  LYS B  180  1                                  17
HELIX   18  18 LEU B  181  ILE B  184  5                                   4
HELIX   19  19 PRO B  201  ILE B  211  1                                  11
HELIX   20  20 VAL B  227  ASP B  231  5                                   5
HELIX   21  21 ASP B  233  ALA B  249  1                                  17
HELIX   22  22 THR C   32  SER C   35  5                                   4
HELIX   23  23 MET C   36  ALA C   46  1                                  11
HELIX   24  24 HIS C   61  GLU C   66  1                                   6
HELIX   25  25 THR C   69  GLN C   86  1                                  18
HELIX   26  26 SER C   97  HIS C  110  1                                  14
HELIX   27  27 ILE C  125  THR C  133  1                                   9
HELIX   28  28 THR C  164  LYS C  180  1                                  17
HELIX   29  29 LEU C  181  ILE C  184  5                                   4
HELIX   30  30 GLY C  202  ILE C  211  1                                  10
HELIX   31  31 ASP C  233  ALA C  249  1                                  17
HELIX   32  32 THR D   32  SER D   35  5                                   4
HELIX   33  33 MET D   36  ALA D   46  1                                  11
HELIX   34  34 HIS D   61  ARG D   67  1                                   7
HELIX   35  35 THR D   69  GLN D   86  1                                  18
HELIX   36  36 SER D   97  HIS D  110  1                                  14
HELIX   37  37 ILE D  125  THR D  133  1                                   9
HELIX   38  38 THR D  164  LYS D  180  1                                  17
HELIX   39  39 LEU D  181  ILE D  184  5                                   4
HELIX   40  40 GLY D  202  ILE D  211  1                                  10
HELIX   41  41 ASP D  233  ALA D  249  1                                  17
SHEET    1   A 5 PHE A  14  ALA A  16  0
SHEET    2   A 5 THR A  49  LEU A  52 -1  O  LEU A  52   N  PHE A  14
SHEET    3   A 5 VAL A  21  VAL A  26  1  N  VAL A  23   O  THR A  49
SHEET    4   A 5 THR A  90  LEU A  96  1  O  THR A  94   N  LEU A  24
SHEET    5   A 5 ILE A 113  ILE A 119  1  O  ILE A 119   N  GLY A  95
SHEET    1   B 2 TYR A 141  ASP A 143  0
SHEET    2   B 2 LYS A 161  PRO A 163 -1  O  THR A 162   N  LEU A 142
SHEET    1   C 2 ALA A 188  SER A 193  0
SHEET    2   C 2 LYS A 216  LEU A 221  1  O  VAL A 219   N  ILE A 190
SHEET    1   D 5 PHE B  14  ALA B  16  0
SHEET    2   D 5 THR B  49  LEU B  52 -1  O  LEU B  52   N  PHE B  14
SHEET    3   D 5 VAL B  21  VAL B  26  1  N  VAL B  23   O  THR B  49
SHEET    4   D 5 THR B  90  LEU B  96  1  O  PHE B  92   N  LEU B  24
SHEET    5   D 5 GLY B 115  ILE B 119  1  O  ILE B 119   N  GLY B  95
SHEET    1   E 2 TYR B 141  ASP B 143  0
SHEET    2   E 2 LYS B 161  PRO B 163 -1  O  THR B 162   N  LEU B 142
SHEET    1   F 2 ALA B 188  SER B 193  0
SHEET    2   F 2 LYS B 216  LEU B 221  1  O  VAL B 219   N  ILE B 190
SHEET    1   G 5 PHE C  14  ALA C  16  0
SHEET    2   G 5 THR C  49  LEU C  52 -1  O  LEU C  52   N  PHE C  14
SHEET    3   G 5 VAL C  21  VAL C  26  1  N  VAL C  23   O  THR C  49
SHEET    4   G 5 THR C  90  LEU C  96  1  O  THR C  94   N  LEU C  24
SHEET    5   G 5 GLY C 115  ILE C 119  1  O  ILE C 119   N  GLY C  95
SHEET    1   H 2 TYR C 141  ASP C 143  0
SHEET    2   H 2 LYS C 161  PRO C 163 -1  O  THR C 162   N  LEU C 142
SHEET    1   I 2 ALA C 188  SER C 193  0
SHEET    2   I 2 LYS C 216  LEU C 221  1  O  VAL C 219   N  ILE C 190
SHEET    1   J 5 PHE D  14  ALA D  16  0
SHEET    2   J 5 THR D  49  LEU D  52 -1  O  LEU D  52   N  PHE D  14
SHEET    3   J 5 VAL D  21  VAL D  26  1  N  VAL D  23   O  THR D  49
SHEET    4   J 5 THR D  90  LEU D  96  1  O  THR D  90   N  GLY D  22
SHEET    5   J 5 GLY D 115  ILE D 119  1  O  ILE D 119   N  GLY D  95
SHEET    1   K 2 TYR D 141  ASP D 143  0
SHEET    2   K 2 LYS D 161  PRO D 163 -1  O  THR D 162   N  LEU D 142
SHEET    1   L 2 ALA D 188  SER D 193  0
SHEET    2   L 2 LYS D 216  LEU D 221  1  O  GLU D 217   N  ILE D 190
LINK         OG  SER A  97                 P1  1R1 A 301     1555   1555  1.57
LINK         OG  SER D  97                 P1  1R1 D 301     1555   1555  1.67
LINK         OG  SER B  97                 P1  1R1 B 301     1555   1555  1.53
LINK         OG  SER C  97                 P1  1R1 C 301     1555   1555  1.65
SITE     1 AC1 10 PHE A  29  SER A  97  MET A  98  ILE A 128
SITE     2 AC1 10 MET A 132  LEU A 142  LEU A 168  LEU A 170
SITE     3 AC1 10 HIS A 226  HOH A 451
SITE     1 AC2 12 GLY B  28  PHE B  29  SER B  97  MET B  98
SITE     2 AC2 12 ILE B 128  MET B 132  LEU B 138  LEU B 142
SITE     3 AC2 12 ILE B 145  LEU B 168  VAL B 198  HIS B 226
SITE     1 AC3 17 GLY C  28  PHE C  29  THR C  30  SER C  97
SITE     2 AC3 17 MET C  98  ALA C 127  ILE C 128  GLY C 131
SITE     3 AC3 17 MET C 132  LEU C 142  ILE C 145  GLY C 146
SITE     4 AC3 17 THR C 164  LEU C 167  LEU C 170  HIS C 226
SITE     5 AC3 17 VAL C 227
SITE     1 AC4 14 GLY D  28  PHE D  29  SER D  97  MET D  98
SITE     2 AC4 14 ILE D 128  PRO D 139  LEU D 142  ILE D 145
SITE     3 AC4 14 GLY D 146  SER D 147  ASP D 148  GLU D 156
SITE     4 AC4 14 LEU D 170  HIS D 226
CRYST1   76.857   80.287   85.712  90.00 100.02  90.00 P 1 21 1      8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.013011  0.000000  0.002299        0.00000
SCALE2      0.000000  0.012455  0.000000        0.00000
SCALE3      0.000000  0.000000  0.011848        0.00000
TER    1907      ALA A 249
TER    3814      ALA B 249
TER    5712      ALA C 249
TER    7619      ALA D 249
MASTER      394    0    4   41   36    0   15    6 8018    4  104   84
END