longtext: 4NVR-pdb

content
HEADER    TRANSFERASE                             05-DEC-13   4NVR
TITLE     2.22 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF A PUTATIVE
TITLE    2 ACYLTRANSFERASE FROM SALMONELLA ENTERICA
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: PUTATIVE ACYLTRANSFERASE;
COMPND   3 CHAIN: A, B, C, D;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: SALMONELLA ENTERICA;
SOURCE   3 ORGANISM_TAXID: 99287;
SOURCE   4 STRAIN: LT2 / SGSC1412 / ATCC 700720;
SOURCE   5 GENE: MHPC, STM0332;
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: BL21-CODONPLUS(DE3)-RIPL;
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PMCSG7
KEYWDS    STRUCTURAL GENOMICS, CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS
KEYWDS   2 DISEASES, CSGID, ALPHA/BETA HYDROLASE FAMILY, TRANSFERASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    G.MINASOV,Z.WAWRZAK,T.SKARINA,E.GORDON,J.STAM,K.KWON,A.SAVCHENKO,
AUTHOR   2 W.F.ANDERSON,CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES
AUTHOR   3 (CSGID)
REVDAT   1   18-DEC-13 4NVR    0
JRNL        AUTH   G.MINASOV,Z.WAWRZAK,T.SKARINA,E.GORDON,J.STAM,K.KWON,
JRNL        AUTH 2 A.SAVCHENKO,W.F.ANDERSON
JRNL        TITL   2.22 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF A PUTATIVE
JRNL        TITL 2 ACYLTRANSFERASE FROM SALMONELLA ENTERICA.
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    2.22 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.8.0046
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.22
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 28.63
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.1
REMARK   3   NUMBER OF REFLECTIONS             : 50666
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.184
REMARK   3   R VALUE            (WORKING SET) : 0.181
REMARK   3   FREE R VALUE                     : 0.241
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.100
REMARK   3   FREE R VALUE TEST SET COUNT      : 2697
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.22
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.28
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 3600
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 94.50
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2320
REMARK   3   BIN FREE R VALUE SET COUNT          : 198
REMARK   3   BIN FREE R VALUE                    : 0.3130
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 9482
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 7
REMARK   3   SOLVENT ATOMS            : 597
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 27.30
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 28.82
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : 0.14000
REMARK   3    B22 (A**2) : -1.82000
REMARK   3    B33 (A**2) : 1.00000
REMARK   3    B12 (A**2) : -1.03000
REMARK   3    B13 (A**2) : 0.02000
REMARK   3    B23 (A**2) : 0.36000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.422
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.247
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.180
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 13.842
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.943
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.899
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  9906 ; 0.011 ; 0.019
REMARK   3   BOND LENGTHS OTHERS               (A):  9239 ; 0.002 ; 0.020
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 13481 ; 1.566 ; 1.958
REMARK   3   BOND ANGLES OTHERS          (DEGREES): 21245 ; 0.792 ; 3.000
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  1232 ; 3.178 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   455 ;29.455 ;23.099
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  1484 ;11.051 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    71 ;14.681 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  1463 ; 0.093 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A): 11342 ; 0.020 ; 0.021
REMARK   3   GENERAL PLANES OTHERS             (A):  2393 ; 0.017 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  4904 ; 1.312 ; 1.267
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  4903 ; 1.312 ; 1.267
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  6140 ; 1.394 ; 1.894
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2):  6141 ; 1.394 ; 1.894
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  5002 ; 1.513 ; 1.431
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2):  5002 ; 1.513 ; 1.431
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2):  7341 ; 2.100 ; 2.085
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2): 11884 ; 5.106 ;11.317
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2): 11693 ; 5.002 ;11.049
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 19
REMARK   3
REMARK   3   TLS GROUP : 1
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A     3        A    22
REMARK   3    ORIGIN FOR THE GROUP (A):  45.5108  42.0117  99.5046
REMARK   3    T TENSOR
REMARK   3      T11:   0.4219 T22:   0.3884
REMARK   3      T33:   0.3460 T12:  -0.0039
REMARK   3      T13:  -0.1843 T23:   0.1100
REMARK   3    L TENSOR
REMARK   3      L11:   9.6720 L22:   1.8978
REMARK   3      L33:   3.3526 L12:  -0.1420
REMARK   3      L13:  -0.8157 L23:  -0.5699
REMARK   3    S TENSOR
REMARK   3      S11:   0.3974 S12:  -0.7031 S13:  -0.9321
REMARK   3      S21:   0.4591 S22:  -0.4269 S23:  -0.5759
REMARK   3      S31:   0.1123 S32:   0.1582 S33:   0.0295
REMARK   3
REMARK   3   TLS GROUP : 2
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A    23        A   185
REMARK   3    ORIGIN FOR THE GROUP (A):  36.7255  44.5018  83.5337
REMARK   3    T TENSOR
REMARK   3      T11:   0.0779 T22:   0.1397
REMARK   3      T33:   0.0202 T12:   0.0693
REMARK   3      T13:  -0.0097 T23:  -0.0071
REMARK   3    L TENSOR
REMARK   3      L11:   0.4618 L22:   1.0213
REMARK   3      L33:   1.7704 L12:   0.3193
REMARK   3      L13:   0.3967 L23:   0.2172
REMARK   3    S TENSOR
REMARK   3      S11:   0.0551 S12:  -0.0838 S13:  -0.0205
REMARK   3      S21:   0.0474 S22:   0.0431 S23:   0.0496
REMARK   3      S31:  -0.1253 S32:  -0.2731 S33:  -0.0982
REMARK   3
REMARK   3   TLS GROUP : 3
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A   186        A   198
REMARK   3    ORIGIN FOR THE GROUP (A):  52.0839  47.9482  73.3330
REMARK   3    T TENSOR
REMARK   3      T11:   0.7586 T22:   0.8238
REMARK   3      T33:   1.0679 T12:  -0.1832
REMARK   3      T13:  -0.5360 T23:   0.3280
REMARK   3    L TENSOR
REMARK   3      L11:   1.6494 L22:  19.3131
REMARK   3      L33:   0.1006 L12:   5.6195
REMARK   3      L13:  -0.3780 L23:  -1.3339
REMARK   3    S TENSOR
REMARK   3      S11:  -0.6793 S12:   0.2972 S13:   0.6910
REMARK   3      S21:  -2.1196 S22:   0.7693 S23:   2.0362
REMARK   3      S31:   0.0916 S32:  -0.0033 S33:  -0.0900
REMARK   3
REMARK   3   TLS GROUP : 4
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A   199        A   304
REMARK   3    ORIGIN FOR THE GROUP (A):  37.8853  51.9366  79.5270
REMARK   3    T TENSOR
REMARK   3      T11:   0.1438 T22:   0.1515
REMARK   3      T33:   0.0199 T12:   0.1015
REMARK   3      T13:   0.0141 T23:  -0.0171
REMARK   3    L TENSOR
REMARK   3      L11:   0.4055 L22:   0.8844
REMARK   3      L33:   1.4978 L12:  -0.1052
REMARK   3      L13:   0.1442 L23:  -0.1641
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0208 S12:  -0.0000 S13:   0.0338
REMARK   3      S21:  -0.0235 S22:   0.1141 S23:  -0.0113
REMARK   3      S31:  -0.3490 S32:  -0.1897 S33:  -0.0932
REMARK   3
REMARK   3   TLS GROUP : 5
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   B     3        B    15
REMARK   3    ORIGIN FOR THE GROUP (A):  24.0089  -1.2089  35.4957
REMARK   3    T TENSOR
REMARK   3      T11:   0.2475 T22:   0.2004
REMARK   3      T33:   0.0922 T12:   0.0460
REMARK   3      T13:   0.0873 T23:   0.0173
REMARK   3    L TENSOR
REMARK   3      L11:  13.6364 L22:   4.3516
REMARK   3      L33:   6.9267 L12:  -5.0468
REMARK   3      L13:   4.1635 L23:  -4.4935
REMARK   3    S TENSOR
REMARK   3      S11:   0.0113 S12:   0.5177 S13:   0.3940
REMARK   3      S21:  -0.4097 S22:  -0.1723 S23:  -0.4084
REMARK   3      S31:  -0.0338 S32:  -0.1698 S33:   0.1611
REMARK   3
REMARK   3   TLS GROUP : 6
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   B    16        B   185
REMARK   3    ORIGIN FOR THE GROUP (A):  13.2809  -2.9221  50.7869
REMARK   3    T TENSOR
REMARK   3      T11:   0.0644 T22:   0.1163
REMARK   3      T33:   0.0257 T12:  -0.0034
REMARK   3      T13:  -0.0038 T23:  -0.0184
REMARK   3    L TENSOR
REMARK   3      L11:   0.4155 L22:   1.0839
REMARK   3      L33:   1.8383 L12:  -0.1496
REMARK   3      L13:  -0.1825 L23:   0.3305
REMARK   3    S TENSOR
REMARK   3      S11:   0.0333 S12:   0.0660 S13:   0.0350
REMARK   3      S21:  -0.0309 S22:  -0.0056 S23:   0.0939
REMARK   3      S31:   0.1051 S32:  -0.2115 S33:  -0.0276
REMARK   3
REMARK   3   TLS GROUP : 7
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   B   186        B   198
REMARK   3    ORIGIN FOR THE GROUP (A):  28.1980  -6.5665  61.7177
REMARK   3    T TENSOR
REMARK   3      T11:   0.5227 T22:   0.5614
REMARK   3      T33:   0.4886 T12:  -0.0055
REMARK   3      T13:   0.1351 T23:   0.0720
REMARK   3    L TENSOR
REMARK   3      L11:  17.5616 L22:  13.7270
REMARK   3      L33:   6.4112 L12: -15.2731
REMARK   3      L13: -10.5632 L23:   9.0270
REMARK   3    S TENSOR
REMARK   3      S11:  -1.5313 S12:  -0.6580 S13:  -2.4402
REMARK   3      S21:   1.3644 S22:   0.0719 S23:   2.0842
REMARK   3      S31:   0.8814 S32:   0.5659 S33:   1.4594
REMARK   3
REMARK   3   TLS GROUP : 8
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   B   199        B   304
REMARK   3    ORIGIN FOR THE GROUP (A):  14.0616 -10.4804  55.5260
REMARK   3    T TENSOR
REMARK   3      T11:   0.1375 T22:   0.1294
REMARK   3      T33:   0.0161 T12:  -0.0262
REMARK   3      T13:  -0.0228 T23:  -0.0299
REMARK   3    L TENSOR
REMARK   3      L11:   0.5980 L22:   1.2215
REMARK   3      L33:   1.4423 L12:   0.1477
REMARK   3      L13:  -0.1250 L23:   0.1446
REMARK   3    S TENSOR
REMARK   3      S11:   0.0155 S12:  -0.0213 S13:  -0.0162
REMARK   3      S21:   0.0597 S22:   0.0200 S23:   0.0205
REMARK   3      S31:   0.3297 S32:  -0.1668 S33:  -0.0355
REMARK   3
REMARK   3   TLS GROUP : 9
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   C     4        C    29
REMARK   3    ORIGIN FOR THE GROUP (A):  49.5639  18.7839  35.3913
REMARK   3    T TENSOR
REMARK   3      T11:   0.2732 T22:   0.3654
REMARK   3      T33:   0.3177 T12:   0.0462
REMARK   3      T13:   0.0881 T23:  -0.1237
REMARK   3    L TENSOR
REMARK   3      L11:   4.6288 L22:   2.7611
REMARK   3      L33:   5.5986 L12:  -0.6556
REMARK   3      L13:  -0.6064 L23:   1.1947
REMARK   3    S TENSOR
REMARK   3      S11:   0.0658 S12:   0.1297 S13:  -0.4956
REMARK   3      S21:  -0.5502 S22:   0.1425 S23:  -0.7135
REMARK   3      S31:  -0.0255 S32:   0.4885 S33:  -0.2083
REMARK   3
REMARK   3   TLS GROUP : 10
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   C    30        C    72
REMARK   3    ORIGIN FOR THE GROUP (A):  38.7052  19.6915  38.0152
REMARK   3    T TENSOR
REMARK   3      T11:   0.1467 T22:   0.1421
REMARK   3      T33:   0.0519 T12:  -0.0107
REMARK   3      T13:  -0.0064 T23:  -0.0586
REMARK   3    L TENSOR
REMARK   3      L11:   0.7609 L22:   3.2642
REMARK   3      L33:   4.7642 L12:   0.0486
REMARK   3      L13:  -0.3616 L23:   0.7984
REMARK   3    S TENSOR
REMARK   3      S11:   0.0709 S12:   0.1445 S13:  -0.1477
REMARK   3      S21:  -0.4113 S22:   0.1300 S23:  -0.1349
REMARK   3      S31:  -0.0307 S32:   0.0054 S33:  -0.2008
REMARK   3
REMARK   3   TLS GROUP : 11
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   C    73        C   242
REMARK   3    ORIGIN FOR THE GROUP (A):  40.3946  32.1824  47.3301
REMARK   3    T TENSOR
REMARK   3      T11:   0.1818 T22:   0.1042
REMARK   3      T33:   0.0229 T12:  -0.0400
REMARK   3      T13:   0.0196 T23:  -0.0460
REMARK   3    L TENSOR
REMARK   3      L11:   0.3955 L22:   1.0417
REMARK   3      L33:   1.7149 L12:  -0.1294
REMARK   3      L13:   0.0988 L23:   0.9033
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0465 S12:   0.0895 S13:  -0.0329
REMARK   3      S21:  -0.3147 S22:   0.1082 S23:  -0.0814
REMARK   3      S31:  -0.4006 S32:   0.1292 S33:  -0.0618
REMARK   3
REMARK   3   TLS GROUP : 12
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   C   243        C   289
REMARK   3    ORIGIN FOR THE GROUP (A):  24.4983  30.7558  43.6114
REMARK   3    T TENSOR
REMARK   3      T11:   0.2431 T22:   0.2294
REMARK   3      T33:   0.1014 T12:   0.0591
REMARK   3      T13:  -0.0773 T23:  -0.0376
REMARK   3    L TENSOR
REMARK   3      L11:   1.6233 L22:   1.5364
REMARK   3      L33:   3.1776 L12:  -0.8395
REMARK   3      L13:   0.2121 L23:   0.2701
REMARK   3    S TENSOR
REMARK   3      S11:   0.0665 S12:   0.0273 S13:  -0.1094
REMARK   3      S21:  -0.1638 S22:  -0.0724 S23:   0.3323
REMARK   3      S31:  -0.4833 S32:  -0.4143 S33:   0.0059
REMARK   3
REMARK   3   TLS GROUP : 13
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   C   290        C   304
REMARK   3    ORIGIN FOR THE GROUP (A):  24.0700  20.7205  34.6121
REMARK   3    T TENSOR
REMARK   3      T11:   0.1215 T22:   0.1140
REMARK   3      T33:   0.0864 T12:   0.0245
REMARK   3      T13:  -0.0693 T23:  -0.0667
REMARK   3    L TENSOR
REMARK   3      L11:   8.8823 L22:   8.1526
REMARK   3      L33:  21.3703 L12:  -2.5953
REMARK   3      L13:   4.8863 L23:  -6.3467
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0550 S12:   0.1050 S13:  -0.2265
REMARK   3      S21:  -0.4926 S22:   0.2550 S23:   0.3795
REMARK   3      S31:  -0.2897 S32:  -0.5405 S33:  -0.2000
REMARK   3
REMARK   3   TLS GROUP : 14
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   D     4        D    14
REMARK   3    ORIGIN FOR THE GROUP (A):  23.3873  28.8001  97.7793
REMARK   3    T TENSOR
REMARK   3      T11:   0.5116 T22:   0.4544
REMARK   3      T33:   0.6342 T12:  -0.1214
REMARK   3      T13:  -0.1717 T23:   0.0545
REMARK   3    L TENSOR
REMARK   3      L11:  14.8227 L22:   6.7053
REMARK   3      L33:   9.9366 L12:  -7.0097
REMARK   3      L13:  11.6844 L23:  -4.3473
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0542 S12:   0.1745 S13:  -0.7983
REMARK   3      S21:   0.1769 S22:   0.4942 S23:  -0.2056
REMARK   3      S31:  -0.3080 S32:   0.5204 S33:  -0.4400
REMARK   3
REMARK   3   TLS GROUP : 15
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   D    15        D    79
REMARK   3    ORIGIN FOR THE GROUP (A):  18.3174  20.4932  97.1967
REMARK   3    T TENSOR
REMARK   3      T11:   0.1361 T22:   0.1416
REMARK   3      T33:   0.0520 T12:   0.0611
REMARK   3      T13:  -0.0315 T23:  -0.0510
REMARK   3    L TENSOR
REMARK   3      L11:   1.5643 L22:   1.3412
REMARK   3      L33:   3.7597 L12:  -0.4171
REMARK   3      L13:   0.3203 L23:   0.0733
REMARK   3    S TENSOR
REMARK   3      S11:   0.0176 S12:  -0.1167 S13:   0.2130
REMARK   3      S21:   0.2417 S22:   0.0522 S23:  -0.1881
REMARK   3      S31:  -0.0134 S32:   0.2398 S33:  -0.0699
REMARK   3
REMARK   3   TLS GROUP : 16
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   D    80        D   182
REMARK   3    ORIGIN FOR THE GROUP (A):  15.7522   6.9418  89.7262
REMARK   3    T TENSOR
REMARK   3      T11:   0.3024 T22:   0.1194
REMARK   3      T33:   0.0284 T12:   0.1052
REMARK   3      T13:  -0.0100 T23:  -0.0403
REMARK   3    L TENSOR
REMARK   3      L11:   0.8227 L22:   0.8795
REMARK   3      L33:   1.9969 L12:   0.2738
REMARK   3      L13:  -0.4325 L23:   0.9892
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0969 S12:  -0.0863 S13:  -0.0573
REMARK   3      S21:   0.3276 S22:   0.0631 S23:  -0.0540
REMARK   3      S31:   0.6272 S32:   0.1033 S33:   0.0338
REMARK   3
REMARK   3   TLS GROUP : 17
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   D   183        D   243
REMARK   3    ORIGIN FOR THE GROUP (A):  16.3277  12.4359  84.4455
REMARK   3    T TENSOR
REMARK   3      T11:   0.1276 T22:   0.0915
REMARK   3      T33:   0.0396 T12:   0.0657
REMARK   3      T13:  -0.0179 T23:  -0.0415
REMARK   3    L TENSOR
REMARK   3      L11:   0.3628 L22:   1.1188
REMARK   3      L33:   2.8689 L12:  -0.4879
REMARK   3      L13:  -0.2298 L23:  -0.0783
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0398 S12:  -0.0454 S13:   0.0738
REMARK   3      S21:   0.0750 S22:   0.0802 S23:  -0.0402
REMARK   3      S31:   0.4076 S32:   0.0850 S33:  -0.0404
REMARK   3
REMARK   3   TLS GROUP : 18
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   D   244        D   289
REMARK   3    ORIGIN FOR THE GROUP (A):   0.2744  10.7185  90.7742
REMARK   3    T TENSOR
REMARK   3      T11:   0.3007 T22:   0.3143
REMARK   3      T33:   0.1571 T12:  -0.0230
REMARK   3      T13:   0.0308 T23:  -0.0319
REMARK   3    L TENSOR
REMARK   3      L11:   1.1336 L22:   1.4470
REMARK   3      L33:   3.4389 L12:   0.9814
REMARK   3      L13:   0.2562 L23:   0.6572
REMARK   3    S TENSOR
REMARK   3      S11:   0.0775 S12:   0.0164 S13:   0.2053
REMARK   3      S21:   0.1316 S22:  -0.0442 S23:   0.3927
REMARK   3      S31:   0.6362 S32:  -0.4765 S33:  -0.0333
REMARK   3
REMARK   3   TLS GROUP : 19
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   D   290        D   304
REMARK   3    ORIGIN FOR THE GROUP (A):  -0.2447  20.4873 100.1924
REMARK   3    T TENSOR
REMARK   3      T11:   0.0895 T22:   0.1629
REMARK   3      T33:   0.0802 T12:   0.0577
REMARK   3      T13:   0.0410 T23:  -0.0408
REMARK   3    L TENSOR
REMARK   3      L11:   4.9694 L22:   7.6688
REMARK   3      L33:  20.2713 L12:   1.7518
REMARK   3      L13:  -1.7145 L23:  -4.8538
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0189 S12:  -0.0413 S13:   0.1181
REMARK   3      S21:   0.6165 S22:   0.3460 S23:   0.5630
REMARK   3      S31:  -0.4537 S32:  -0.8889 S33:  -0.3271
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING
REMARK   3  POSITIONS
REMARK   4
REMARK   4 4NVR COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 06-DEC-13.
REMARK 100 THE RCSB ID CODE IS RCSB083716.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 11-JUN-09
REMARK 200  TEMPERATURE           (KELVIN) : 100.0
REMARK 200  PH                             : 6.5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : APS
REMARK 200  BEAMLINE                       : 21-ID-F
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.97872
REMARK 200  MONOCHROMATOR                  : DIAMOND
REMARK 200  OPTICS                         : BERYLLIUM LENSES
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : MARMOSAIC 225 MM CCD
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 53580
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.220
REMARK 200  RESOLUTION RANGE LOW       (A) : 30.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : -3.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.2
REMARK 200  DATA REDUNDANCY                : 5.800
REMARK 200  R MERGE                    (I) : 0.12000
REMARK 200  R SYM                      (I) : 0.12000
REMARK 200   FOR THE DATA SET  : 19.4000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.22
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.26
REMARK 200  COMPLETENESS FOR SHELL     (%) : 92.3
REMARK 200  DATA REDUNDANCY IN SHELL       : 4.90
REMARK 200  R MERGE FOR SHELL          (I) : 0.45800
REMARK 200  R SYM FOR SHELL            (I) : 0.45800
REMARK 200   FOR SHELL         : 3.600
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: SAD
REMARK 200 SOFTWARE USED: PHENIX
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 40.18
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.06
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: PROTEIN: 8.8MG/ML, 0.3M SODIUM
REMARK 280  CLORIDE, 0.1M HEPES, PH 7.5. SCREEN: 0.2M CALCIUM ACETATE, 0.1M
REMARK 280  NA CACODYLATE, PH 6.5, 9% (W/V) PEG 8000, VAPOR DIFFUSION,
REMARK 280  HANGING DROP, TEMPERATURE 295K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 2400 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 21780 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -64.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 2330 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 21810 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -50.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     SER A    -2
REMARK 465     ASN A    -1
REMARK 465     ALA A     0
REMARK 465     MSE A     1
REMARK 465     SER A     2
REMARK 465     SER B    -2
REMARK 465     ASN B    -1
REMARK 465     ALA B     0
REMARK 465     MSE B     1
REMARK 465     SER B     2
REMARK 465     SER C    -2
REMARK 465     ASN C    -1
REMARK 465     ALA C     0
REMARK 465     MSE C     1
REMARK 465     SER C     2
REMARK 465     THR C     3
REMARK 465     SER D    -2
REMARK 465     ASN D    -1
REMARK 465     ALA D     0
REMARK 465     MSE D     1
REMARK 465     SER D     2
REMARK 465     THR D     3
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    GLU A 268   OE1 -  CD  -  OE2 ANGL. DEV. =   9.1 DEGREES
REMARK 500    GLU B 268   OE1 -  CD  -  OE2 ANGL. DEV. =   9.9 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    PRO A  47       31.63    -97.07
REMARK 500    SER A  82     -163.04   -105.50
REMARK 500    SER A 108      -75.44   -105.92
REMARK 500    ASP A 116     -125.31     58.76
REMARK 500    ASP A 179       82.11   -162.40
REMARK 500    LEU A 192      -73.57    -88.18
REMARK 500    ILE A 194       94.71   -170.82
REMARK 500    GLU A 195       98.42     12.83
REMARK 500    THR A 228      -86.86   -134.82
REMARK 500    PRO B  47       40.13    -98.40
REMARK 500    SER B 108      -84.66    -97.05
REMARK 500    ASP B 116     -124.57     59.10
REMARK 500    ASP B 179       84.56   -158.87
REMARK 500    LEU B 192      -65.59    -98.78
REMARK 500    LYS B 193       27.77     42.77
REMARK 500    GLU B 195       90.34      3.70
REMARK 500    THR B 228      -90.42   -137.76
REMARK 500    CYS B 280     -176.94   -172.25
REMARK 500    HIS C  44     -178.94    -65.21
REMARK 500    SER C 108     -100.45   -104.51
REMARK 500    ASP C 116     -125.32     57.75
REMARK 500    ASP C 179       85.30   -161.09
REMARK 500    THR C 228      -97.34   -128.26
REMARK 500    HIS D  44     -178.52    -69.31
REMARK 500    ASN D  49     -167.58   -124.02
REMARK 500    SER D 108      -87.84    -75.87
REMARK 500    ASP D 116     -131.36     52.26
REMARK 500    ASP D 179       89.73   -174.52
REMARK 500    THR D 228      -89.72   -131.07
REMARK 500
REMARK 500 REMARK: NULL
REMARK 620
REMARK 620 METAL COORDINATION
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA B 401  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 GLU B 268   OE2
REMARK 620 2 GLU B 268   OE1  60.6
REMARK 620 3 THR B 238   O   105.4 131.9
REMARK 620 4 THR B 238   OG1 139.0 144.8  77.6
REMARK 620 5 HOH B 654   O    71.1 128.4  76.3  70.1
REMARK 620 6 HOH B 586   O   141.2  81.7  92.4  77.8 147.5
REMARK 620 7 HOH B 644   O    80.4  71.5  60.6 130.7 118.7  79.0
REMARK 620 8 HOH B 652   O    93.0  80.5 147.5  71.0  85.0  89.4 150.8
REMARK 620 N                    1     2     3     4     5     6     7
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA A 401  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 GLU A 268   OE1
REMARK 620 2 GLU A 268   OE2  60.2
REMARK 620 3 THR A 238   O   131.3 104.3
REMARK 620 4 THR A 238   OG1 150.2 141.6  71.2
REMARK 620 5 HOH A 633   O    81.6 138.6  88.5  79.8
REMARK 620 6 HOH A 631   O   122.0  65.6  80.0  76.1 155.5
REMARK 620 7 HOH A 632   O    80.0  89.9 148.7  80.3  99.2  80.8
REMARK 620 8 HOH A 598   O    70.9  81.0  60.8 123.5  71.2 119.7 150.2
REMARK 620 N                    1     2     3     4     5     6     7
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA C 402  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 GLU C 205   OE2
REMARK 620 2 ASN C  49   OD1  83.5
REMARK 620 3 HOH C 554   O   116.5  77.0
REMARK 620 N                    1     2
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA D 401  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 SER D 189   O
REMARK 620 2 LEU D 192   O    86.9
REMARK 620 3 HOH D 610   O    77.0  85.2
REMARK 620 4 HOH D 573   O    86.9  86.3 162.2
REMARK 620 N                    1     2     3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA C 401  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 LEU C 192   O
REMARK 620 2 SER C 189   O    85.7
REMARK 620 3 HOH C 516   O    92.0  79.7
REMARK 620 4 HOH C 632   O    84.0  76.2 155.8
REMARK 620 N                    1     2     3
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA A 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL A 402
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA B 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 402
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA C 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA C 402
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA D 401
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: CSGID-IDP01787   RELATED DB: TARGETTRACK
DBREF  4NVR A    1   304  UNP    Q8ZRI7   Q8ZRI7_SALTY     1    304
DBREF  4NVR B    1   304  UNP    Q8ZRI7   Q8ZRI7_SALTY     1    304
DBREF  4NVR C    1   304  UNP    Q8ZRI7   Q8ZRI7_SALTY     1    304
DBREF  4NVR D    1   304  UNP    Q8ZRI7   Q8ZRI7_SALTY     1    304
SEQADV 4NVR SER A   -2  UNP  Q8ZRI7              EXPRESSION TAG
SEQADV 4NVR ASN A   -1  UNP  Q8ZRI7              EXPRESSION TAG
SEQADV 4NVR ALA A    0  UNP  Q8ZRI7              EXPRESSION TAG
SEQADV 4NVR SER B   -2  UNP  Q8ZRI7              EXPRESSION TAG
SEQADV 4NVR ASN B   -1  UNP  Q8ZRI7              EXPRESSION TAG
SEQADV 4NVR ALA B    0  UNP  Q8ZRI7              EXPRESSION TAG
SEQADV 4NVR SER C   -2  UNP  Q8ZRI7              EXPRESSION TAG
SEQADV 4NVR ASN C   -1  UNP  Q8ZRI7              EXPRESSION TAG
SEQADV 4NVR ALA C    0  UNP  Q8ZRI7              EXPRESSION TAG
SEQADV 4NVR SER D   -2  UNP  Q8ZRI7              EXPRESSION TAG
SEQADV 4NVR ASN D   -1  UNP  Q8ZRI7              EXPRESSION TAG
SEQADV 4NVR ALA D    0  UNP  Q8ZRI7              EXPRESSION TAG
SEQRES   1 A  307  SER ASN ALA MSE SER THR LEU ILE GLU CYS GLY ALA SER
SEQRES   2 A  307  PRO PHE ILE PRO GLY PHE ALA LEU LYS ASP VAL ARG LEU
SEQRES   3 A  307  GLU ASN GLY LEU THR VAL ARG VAL ALA ILE GLY GLY SER
SEQRES   4 A  307  GLY SER PRO LEU VAL LEU LEU HIS GLY HIS PRO GLN ASN
SEQRES   5 A  307  HIS THR THR TRP ARG LYS VAL ALA PRO THR LEU ALA GLN
SEQRES   6 A  307  ASN HIS THR VAL ILE LEU PRO ASP LEU ARG GLY TYR GLY
SEQRES   7 A  307  ASP SER ASP LYS PRO THR SER ASP PRO ALA HIS ARG THR
SEQRES   8 A  307  TYR SER LYS ARG THR MSE ALA GLN ASP ILE VAL MSE LEU
SEQRES   9 A  307  MSE ASP ALA LEU GLY PHE SER ARG PHE ALA PHE VAL GLY
SEQRES  10 A  307  HIS ASP ARG GLY GLY ARG VAL GLY HIS ARG LEU ALA LEU
SEQRES  11 A  307  ASP TYR PRO ASP ARG VAL THR CYS CYS THR PHE ILE ASP
SEQRES  12 A  307  ILE ALA PRO THR ALA THR MSE TYR ALA LEU THR ASP LYS
SEQRES  13 A  307  SER PHE ALA THR ARG TYR PHE TRP TRP PHE PHE LEU ILE
SEQRES  14 A  307  GLN PRO PHE PRO LEU PRO GLU THR MSE ILE ALA HIS ASP
SEQRES  15 A  307  PRO ALA PHE PHE LEU ARG LYS HIS ILE SER GLY GLN LEU
SEQRES  16 A  307  LYS ILE GLU GLY ALA THR SER GLN GLU ALA PHE ASN GLU
SEQRES  17 A  307  TYR LEU ARG CYS TYR GLN ASN PRO GLU MSE ILE HIS ALA
SEQRES  18 A  307  ILE CYS GLU ASP TYR ARG ALA ALA ALA THR ILE ASP LEU
SEQRES  19 A  307  ASP ASP ASP ALA ALA ASP THR SER ALA ARG ILE ARG CYS
SEQRES  20 A  307  PRO LEU GLN LEU LEU TRP GLY GLY LEU GLY THR VAL GLY
SEQRES  21 A  307  GLN LEU TYR ASN VAL VAL GLY THR TRP LYS GLU LYS ALA
SEQRES  22 A  307  LEU ASN VAL GLN GLY GLU ALA LEU PRO CYS GLY HIS SER
SEQRES  23 A  307  PRO GLN GLU GLU CYS PRO GLU TYR PHE ILE GLN LYS LEU
SEQRES  24 A  307  GLN SER PHE LEU HIS SER VAL LEU
SEQRES   1 B  307  SER ASN ALA MSE SER THR LEU ILE GLU CYS GLY ALA SER
SEQRES   2 B  307  PRO PHE ILE PRO GLY PHE ALA LEU LYS ASP VAL ARG LEU
SEQRES   3 B  307  GLU ASN GLY LEU THR VAL ARG VAL ALA ILE GLY GLY SER
SEQRES   4 B  307  GLY SER PRO LEU VAL LEU LEU HIS GLY HIS PRO GLN ASN
SEQRES   5 B  307  HIS THR THR TRP ARG LYS VAL ALA PRO THR LEU ALA GLN
SEQRES   6 B  307  ASN HIS THR VAL ILE LEU PRO ASP LEU ARG GLY TYR GLY
SEQRES   7 B  307  ASP SER ASP LYS PRO THR SER ASP PRO ALA HIS ARG THR
SEQRES   8 B  307  TYR SER LYS ARG THR MSE ALA GLN ASP ILE VAL MSE LEU
SEQRES   9 B  307  MSE ASP ALA LEU GLY PHE SER ARG PHE ALA PHE VAL GLY
SEQRES  10 B  307  HIS ASP ARG GLY GLY ARG VAL GLY HIS ARG LEU ALA LEU
SEQRES  11 B  307  ASP TYR PRO ASP ARG VAL THR CYS CYS THR PHE ILE ASP
SEQRES  12 B  307  ILE ALA PRO THR ALA THR MSE TYR ALA LEU THR ASP LYS
SEQRES  13 B  307  SER PHE ALA THR ARG TYR PHE TRP TRP PHE PHE LEU ILE
SEQRES  14 B  307  GLN PRO PHE PRO LEU PRO GLU THR MSE ILE ALA HIS ASP
SEQRES  15 B  307  PRO ALA PHE PHE LEU ARG LYS HIS ILE SER GLY GLN LEU
SEQRES  16 B  307  LYS ILE GLU GLY ALA THR SER GLN GLU ALA PHE ASN GLU
SEQRES  17 B  307  TYR LEU ARG CYS TYR GLN ASN PRO GLU MSE ILE HIS ALA
SEQRES  18 B  307  ILE CYS GLU ASP TYR ARG ALA ALA ALA THR ILE ASP LEU
SEQRES  19 B  307  ASP ASP ASP ALA ALA ASP THR SER ALA ARG ILE ARG CYS
SEQRES  20 B  307  PRO LEU GLN LEU LEU TRP GLY GLY LEU GLY THR VAL GLY
SEQRES  21 B  307  GLN LEU TYR ASN VAL VAL GLY THR TRP LYS GLU LYS ALA
SEQRES  22 B  307  LEU ASN VAL GLN GLY GLU ALA LEU PRO CYS GLY HIS SER
SEQRES  23 B  307  PRO GLN GLU GLU CYS PRO GLU TYR PHE ILE GLN LYS LEU
SEQRES  24 B  307  GLN SER PHE LEU HIS SER VAL LEU
SEQRES   1 C  307  SER ASN ALA MSE SER THR LEU ILE GLU CYS GLY ALA SER
SEQRES   2 C  307  PRO PHE ILE PRO GLY PHE ALA LEU LYS ASP VAL ARG LEU
SEQRES   3 C  307  GLU ASN GLY LEU THR VAL ARG VAL ALA ILE GLY GLY SER
SEQRES   4 C  307  GLY SER PRO LEU VAL LEU LEU HIS GLY HIS PRO GLN ASN
SEQRES   5 C  307  HIS THR THR TRP ARG LYS VAL ALA PRO THR LEU ALA GLN
SEQRES   6 C  307  ASN HIS THR VAL ILE LEU PRO ASP LEU ARG GLY TYR GLY
SEQRES   7 C  307  ASP SER ASP LYS PRO THR SER ASP PRO ALA HIS ARG THR
SEQRES   8 C  307  TYR SER LYS ARG THR MSE ALA GLN ASP ILE VAL MSE LEU
SEQRES   9 C  307  MSE ASP ALA LEU GLY PHE SER ARG PHE ALA PHE VAL GLY
SEQRES  10 C  307  HIS ASP ARG GLY GLY ARG VAL GLY HIS ARG LEU ALA LEU
SEQRES  11 C  307  ASP TYR PRO ASP ARG VAL THR CYS CYS THR PHE ILE ASP
SEQRES  12 C  307  ILE ALA PRO THR ALA THR MSE TYR ALA LEU THR ASP LYS
SEQRES  13 C  307  SER PHE ALA THR ARG TYR PHE TRP TRP PHE PHE LEU ILE
SEQRES  14 C  307  GLN PRO PHE PRO LEU PRO GLU THR MSE ILE ALA HIS ASP
SEQRES  15 C  307  PRO ALA PHE PHE LEU ARG LYS HIS ILE SER GLY GLN LEU
SEQRES  16 C  307  LYS ILE GLU GLY ALA THR SER GLN GLU ALA PHE ASN GLU
SEQRES  17 C  307  TYR LEU ARG CYS TYR GLN ASN PRO GLU MSE ILE HIS ALA
SEQRES  18 C  307  ILE CYS GLU ASP TYR ARG ALA ALA ALA THR ILE ASP LEU
SEQRES  19 C  307  ASP ASP ASP ALA ALA ASP THR SER ALA ARG ILE ARG CYS
SEQRES  20 C  307  PRO LEU GLN LEU LEU TRP GLY GLY LEU GLY THR VAL GLY
SEQRES  21 C  307  GLN LEU TYR ASN VAL VAL GLY THR TRP LYS GLU LYS ALA
SEQRES  22 C  307  LEU ASN VAL GLN GLY GLU ALA LEU PRO CYS GLY HIS SER
SEQRES  23 C  307  PRO GLN GLU GLU CYS PRO GLU TYR PHE ILE GLN LYS LEU
SEQRES  24 C  307  GLN SER PHE LEU HIS SER VAL LEU
SEQRES   1 D  307  SER ASN ALA MSE SER THR LEU ILE GLU CYS GLY ALA SER
SEQRES   2 D  307  PRO PHE ILE PRO GLY PHE ALA LEU LYS ASP VAL ARG LEU
SEQRES   3 D  307  GLU ASN GLY LEU THR VAL ARG VAL ALA ILE GLY GLY SER
SEQRES   4 D  307  GLY SER PRO LEU VAL LEU LEU HIS GLY HIS PRO GLN ASN
SEQRES   5 D  307  HIS THR THR TRP ARG LYS VAL ALA PRO THR LEU ALA GLN
SEQRES   6 D  307  ASN HIS THR VAL ILE LEU PRO ASP LEU ARG GLY TYR GLY
SEQRES   7 D  307  ASP SER ASP LYS PRO THR SER ASP PRO ALA HIS ARG THR
SEQRES   8 D  307  TYR SER LYS ARG THR MSE ALA GLN ASP ILE VAL MSE LEU
SEQRES   9 D  307  MSE ASP ALA LEU GLY PHE SER ARG PHE ALA PHE VAL GLY
SEQRES  10 D  307  HIS ASP ARG GLY GLY ARG VAL GLY HIS ARG LEU ALA LEU
SEQRES  11 D  307  ASP TYR PRO ASP ARG VAL THR CYS CYS THR PHE ILE ASP
SEQRES  12 D  307  ILE ALA PRO THR ALA THR MSE TYR ALA LEU THR ASP LYS
SEQRES  13 D  307  SER PHE ALA THR ARG TYR PHE TRP TRP PHE PHE LEU ILE
SEQRES  14 D  307  GLN PRO PHE PRO LEU PRO GLU THR MSE ILE ALA HIS ASP
SEQRES  15 D  307  PRO ALA PHE PHE LEU ARG LYS HIS ILE SER GLY GLN LEU
SEQRES  16 D  307  LYS ILE GLU GLY ALA THR SER GLN GLU ALA PHE ASN GLU
SEQRES  17 D  307  TYR LEU ARG CYS TYR GLN ASN PRO GLU MSE ILE HIS ALA
SEQRES  18 D  307  ILE CYS GLU ASP TYR ARG ALA ALA ALA THR ILE ASP LEU
SEQRES  19 D  307  ASP ASP ASP ALA ALA ASP THR SER ALA ARG ILE ARG CYS
SEQRES  20 D  307  PRO LEU GLN LEU LEU TRP GLY GLY LEU GLY THR VAL GLY
SEQRES  21 D  307  GLN LEU TYR ASN VAL VAL GLY THR TRP LYS GLU LYS ALA
SEQRES  22 D  307  LEU ASN VAL GLN GLY GLU ALA LEU PRO CYS GLY HIS SER
SEQRES  23 D  307  PRO GLN GLU GLU CYS PRO GLU TYR PHE ILE GLN LYS LEU
SEQRES  24 D  307  GLN SER PHE LEU HIS SER VAL LEU
MODRES 4NVR MSE A   94  MET  SELENOMETHIONINE
MODRES 4NVR MSE A  100  MET  SELENOMETHIONINE
MODRES 4NVR MSE A  102  MET  SELENOMETHIONINE
MODRES 4NVR MSE A  147  MET  SELENOMETHIONINE
MODRES 4NVR MSE A  175  MET  SELENOMETHIONINE
MODRES 4NVR MSE A  215  MET  SELENOMETHIONINE
MODRES 4NVR MSE B   94  MET  SELENOMETHIONINE
MODRES 4NVR MSE B  100  MET  SELENOMETHIONINE
MODRES 4NVR MSE B  102  MET  SELENOMETHIONINE
MODRES 4NVR MSE B  147  MET  SELENOMETHIONINE
MODRES 4NVR MSE B  175  MET  SELENOMETHIONINE
MODRES 4NVR MSE B  215  MET  SELENOMETHIONINE
MODRES 4NVR MSE C   94  MET  SELENOMETHIONINE
MODRES 4NVR MSE C  100  MET  SELENOMETHIONINE
MODRES 4NVR MSE C  102  MET  SELENOMETHIONINE
MODRES 4NVR MSE C  147  MET  SELENOMETHIONINE
MODRES 4NVR MSE C  175  MET  SELENOMETHIONINE
MODRES 4NVR MSE C  215  MET  SELENOMETHIONINE
MODRES 4NVR MSE D   94  MET  SELENOMETHIONINE
MODRES 4NVR MSE D  100  MET  SELENOMETHIONINE
MODRES 4NVR MSE D  102  MET  SELENOMETHIONINE
MODRES 4NVR MSE D  147  MET  SELENOMETHIONINE
MODRES 4NVR MSE D  175  MET  SELENOMETHIONINE
MODRES 4NVR MSE D  215  MET  SELENOMETHIONINE
HET    MSE  A  94       8
HET    MSE  A 100       8
HET    MSE  A 102       8
HET    MSE  A 147       8
HET    MSE  A 175       8
HET    MSE  A 215       8
HET    MSE  B  94       8
HET    MSE  B 100       8
HET    MSE  B 102       8
HET    MSE  B 147       8
HET    MSE  B 175       8
HET    MSE  B 215       8
HET    MSE  C  94       8
HET    MSE  C 100       8
HET    MSE  C 102       8
HET    MSE  C 147       8
HET    MSE  C 175       8
HET    MSE  C 215       8
HET    MSE  D  94       8
HET    MSE  D 100       8
HET    MSE  D 102       8
HET    MSE  D 147       8
HET    MSE  D 175       8
HET    MSE  D 215       8
HET     CA  A 401       1
HET     CL  A 402       1
HET     CA  B 401       1
HET     CL  B 402       1
HET     CA  C 401       1
HET     CA  C 402       1
HET     CA  D 401       1
HETNAM     MSE SELENOMETHIONINE
HETNAM      CA CALCIUM ION
HETNAM      CL CHLORIDE ION
FORMUL   1  MSE    24(C5 H11 N O2 SE)
FORMUL   5   CA    5(CA 2+)
FORMUL   6   CL    2(CL 1-)
FORMUL  12  HOH   *597(H2 O)
HELIX    1   1 ASN A   49  ARG A   54  5                                   6
HELIX    2   2 VAL A   56  ALA A   61  1                                   6
HELIX    3   3 HIS A   86  TYR A   89  5                                   4
HELIX    4   4 SER A   90  LEU A  105  1                                  16
HELIX    5   5 ASP A  116  TYR A  129  1                                  14
HELIX    6   6 PRO A  143  LEU A  150  1                                   8
HELIX    7   7 ASP A  152  TYR A  159  1                                   8
HELIX    8   8 PHE A  160  LEU A  165  1                                   6
HELIX    9   9 PRO A  170  HIS A  178  1                                   9
HELIX   10  10 ASP A  179  LYS A  193  1                                  15
HELIX   11  11 SER A  199  GLN A  211  1                                  13
HELIX   12  12 ASN A  212  ALA A  227  1                                  16
HELIX   13  13 THR A  228  ASP A  237  1                                  10
HELIX   14  14 GLY A  254  TYR A  260  1                                   7
HELIX   15  15 ASN A  261  LYS A  267  1                                   7
HELIX   16  16 SER A  283  CYS A  288  1                                   6
HELIX   17  17 CYS A  288  VAL A  303  1                                  16
HELIX   18  18 ASN B   49  ARG B   54  5                                   6
HELIX   19  19 VAL B   56  ALA B   61  1                                   6
HELIX   20  20 HIS B   86  TYR B   89  5                                   4
HELIX   21  21 SER B   90  LEU B  105  1                                  16
HELIX   22  22 ASP B  116  TYR B  129  1                                  14
HELIX   23  23 PRO B  143  LEU B  150  1                                   8
HELIX   24  24 ASP B  152  TYR B  159  1                                   8
HELIX   25  25 PHE B  160  LEU B  165  1                                   6
HELIX   26  26 PRO B  170  ASP B  179  1                                  10
HELIX   27  27 ASP B  179  LYS B  193  1                                  15
HELIX   28  28 SER B  199  GLN B  211  1                                  13
HELIX   29  29 ASN B  212  ALA B  227  1                                  16
HELIX   30  30 THR B  228  ASP B  237  1                                  10
HELIX   31  31 GLY B  254  TYR B  260  1                                   7
HELIX   32  32 VAL B  263  LYS B  267  5                                   5
HELIX   33  33 SER B  283  CYS B  288  1                                   6
HELIX   34  34 CYS B  288  VAL B  303  1                                  16
HELIX   35  35 ASN C   49  ARG C   54  5                                   6
HELIX   36  36 VAL C   56  ALA C   61  1                                   6
HELIX   37  37 HIS C   86  TYR C   89  5                                   4
HELIX   38  38 SER C   90  GLY C  106  1                                  17
HELIX   39  39 ASP C  116  TYR C  129  1                                  14
HELIX   40  40 PRO C  143  LEU C  150  1                                   8
HELIX   41  41 ASP C  152  TYR C  159  1                                   8
HELIX   42  42 PHE C  160  LEU C  165  1                                   6
HELIX   43  43 PRO C  170  ASP C  179  1                                  10
HELIX   44  44 ASP C  179  LEU C  192  1                                  14
HELIX   45  45 SER C  199  GLN C  211  1                                  13
HELIX   46  46 ASN C  212  THR C  228  1                                  17
HELIX   47  47 THR C  228  ASP C  237  1                                  10
HELIX   48  48 GLY C  254  TYR C  260  1                                   7
HELIX   49  49 ASN C  261  GLU C  268  1                                   8
HELIX   50  50 SER C  283  CYS C  288  1                                   6
HELIX   51  51 CYS C  288  LEU C  304  1                                  17
HELIX   52  52 ASN D   49  ARG D   54  5                                   6
HELIX   53  53 VAL D   56  ALA D   61  1                                   6
HELIX   54  54 HIS D   86  TYR D   89  5                                   4
HELIX   55  55 SER D   90  LEU D  105  1                                  16
HELIX   56  56 ASP D  116  TYR D  129  1                                  14
HELIX   57  57 PRO D  143  LEU D  150  1                                   8
HELIX   58  58 ASP D  152  TYR D  159  1                                   8
HELIX   59  59 PHE D  160  LEU D  165  1                                   6
HELIX   60  60 PRO D  170  HIS D  178  1                                   9
HELIX   61  61 ASP D  179  LEU D  192  1                                  14
HELIX   62  62 SER D  199  GLN D  211  1                                  13
HELIX   63  63 ASN D  212  THR D  228  1                                  17
HELIX   64  64 THR D  228  ASP D  237  1                                  10
HELIX   65  65 GLY D  254  TYR D  260  1                                   7
HELIX   66  66 ASN D  261  GLU D  268  1                                   8
HELIX   67  67 SER D  283  CYS D  288  1                                   6
HELIX   68  68 CYS D  288  LEU D  304  1                                  17
SHEET    1   A 9 LEU A   4  ALA A   9  0
SHEET    2   A 9 ALA A  17  ARG A  22 -1  O  LEU A  18   N  GLY A   8
SHEET    3   A 9 THR A  28  GLY A  35 -1  O  VAL A  31   N  LYS A  19
SHEET    4   A 9 THR A  65  PRO A  69 -1  O  LEU A  68   N  ALA A  32
SHEET    5   A 9 PRO A  39  LEU A  43  1  N  LEU A  40   O  ILE A  67
SHEET    6   A 9 PHE A 110  HIS A 115  1  O  VAL A 113   N  VAL A  41
SHEET    7   A 9 VAL A 133  ILE A 139  1  O  THR A 137   N  GLY A 114
SHEET    8   A 9 LEU A 246  GLY A 251  1  O  GLN A 247   N  CYS A 136
SHEET    9   A 9 VAL A 273  LEU A 278  1  O  LEU A 278   N  TRP A 250
SHEET    1   B 9 LEU B   4  ALA B   9  0
SHEET    2   B 9 ALA B  17  ARG B  22 -1  O  LEU B  18   N  GLY B   8
SHEET    3   B 9 THR B  28  GLY B  35 -1  O  VAL B  29   N  VAL B  21
SHEET    4   B 9 THR B  65  PRO B  69 -1  O  VAL B  66   N  GLY B  34
SHEET    5   B 9 PRO B  39  LEU B  43  1  N  LEU B  40   O  ILE B  67
SHEET    6   B 9 PHE B 110  HIS B 115  1  O  VAL B 113   N  LEU B  43
SHEET    7   B 9 VAL B 133  ILE B 139  1  O  ILE B 139   N  GLY B 114
SHEET    8   B 9 LEU B 246  GLY B 251  1  O  GLN B 247   N  CYS B 136
SHEET    9   B 9 VAL B 273  LEU B 278  1  O  LEU B 278   N  TRP B 250
SHEET    1   C 9 ILE C   5  ALA C   9  0
SHEET    2   C 9 ALA C  17  ARG C  22 -1  O  LEU C  18   N  GLY C   8
SHEET    3   C 9 THR C  28  GLY C  35 -1  O  VAL C  31   N  LYS C  19
SHEET    4   C 9 HIS C  64  PRO C  69 -1  O  LEU C  68   N  ALA C  32
SHEET    5   C 9 SER C  38  LEU C  43  1  N  LEU C  40   O  THR C  65
SHEET    6   C 9 PHE C 110  HIS C 115  1  O  VAL C 113   N  LEU C  43
SHEET    7   C 9 VAL C 133  ILE C 139  1  O  ILE C 139   N  GLY C 114
SHEET    8   C 9 LEU C 246  GLY C 251  1  O  GLN C 247   N  PHE C 138
SHEET    9   C 9 VAL C 273  LEU C 278  1  O  LEU C 278   N  TRP C 250
SHEET    1   D 9 ILE D   5  ALA D   9  0
SHEET    2   D 9 ALA D  17  ARG D  22 -1  O  LEU D  18   N  GLY D   8
SHEET    3   D 9 THR D  28  GLY D  35 -1  O  VAL D  29   N  VAL D  21
SHEET    4   D 9 HIS D  64  PRO D  69 -1  O  VAL D  66   N  GLY D  34
SHEET    5   D 9 SER D  38  LEU D  43  1  N  LEU D  42   O  ILE D  67
SHEET    6   D 9 PHE D 110  HIS D 115  1  O  VAL D 113   N  LEU D  43
SHEET    7   D 9 VAL D 133  ILE D 139  1  O  ILE D 139   N  GLY D 114
SHEET    8   D 9 LEU D 246  GLY D 251  1  O  GLN D 247   N  PHE D 138
SHEET    9   D 9 VAL D 273  LEU D 278  1  O  LEU D 278   N  TRP D 250
LINK         C   THR A  93                 N   MSE A  94     1555   1555  1.33
LINK         C   MSE A  94                 N   ALA A  95     1555   1555  1.34
LINK         C   VAL A  99                 N   MSE A 100     1555   1555  1.33
LINK         C   MSE A 100                 N   LEU A 101     1555   1555  1.34
LINK         C   LEU A 101                 N   MSE A 102     1555   1555  1.33
LINK         C   MSE A 102                 N   ASP A 103     1555   1555  1.34
LINK         C   THR A 146                 N   MSE A 147     1555   1555  1.32
LINK         C   MSE A 147                 N   TYR A 148     1555   1555  1.33
LINK         C   THR A 174                 N   MSE A 175     1555   1555  1.32
LINK         C   MSE A 175                 N   ILE A 176     1555   1555  1.34
LINK         C   GLU A 214                 N   MSE A 215     1555   1555  1.34
LINK         C   MSE A 215                 N  AILE A 216     1555   1555  1.33
LINK         C   MSE A 215                 N  BILE A 216     1555   1555  1.33
LINK         C   THR B  93                 N   MSE B  94     1555   1555  1.33
LINK         C   MSE B  94                 N   ALA B  95     1555   1555  1.33
LINK         C   VAL B  99                 N   MSE B 100     1555   1555  1.34
LINK         C   MSE B 100                 N   LEU B 101     1555   1555  1.34
LINK         C   LEU B 101                 N   MSE B 102     1555   1555  1.34
LINK         C   MSE B 102                 N   ASP B 103     1555   1555  1.33
LINK         C   THR B 146                 N   MSE B 147     1555   1555  1.33
LINK         C   MSE B 147                 N   TYR B 148     1555   1555  1.34
LINK         C   THR B 174                 N   MSE B 175     1555   1555  1.32
LINK         C   MSE B 175                 N   ILE B 176     1555   1555  1.33
LINK         C   GLU B 214                 N   MSE B 215     1555   1555  1.34
LINK         C   MSE B 215                 N   ILE B 216     1555   1555  1.32
LINK         C   THR C  93                 N   MSE C  94     1555   1555  1.32
LINK         C   MSE C  94                 N   ALA C  95     1555   1555  1.33
LINK         C   VAL C  99                 N   MSE C 100     1555   1555  1.33
LINK         C   MSE C 100                 N   LEU C 101     1555   1555  1.32
LINK         C   LEU C 101                 N   MSE C 102     1555   1555  1.34
LINK         C   MSE C 102                 N   ASP C 103     1555   1555  1.33
LINK         C   THR C 146                 N   MSE C 147     1555   1555  1.34
LINK         C   MSE C 147                 N   TYR C 148     1555   1555  1.33
LINK         C   THR C 174                 N   MSE C 175     1555   1555  1.32
LINK         C   MSE C 175                 N   ILE C 176     1555   1555  1.33
LINK         C   GLU C 214                 N   MSE C 215     1555   1555  1.34
LINK         C   MSE C 215                 N  AILE C 216     1555   1555  1.32
LINK         C   MSE C 215                 N  BILE C 216     1555   1555  1.33
LINK         C   THR D  93                 N   MSE D  94     1555   1555  1.33
LINK         C   MSE D  94                 N   ALA D  95     1555   1555  1.33
LINK         C   VAL D  99                 N   MSE D 100     1555   1555  1.33
LINK         C   MSE D 100                 N   LEU D 101     1555   1555  1.32
LINK         C   LEU D 101                 N   MSE D 102     1555   1555  1.33
LINK         C   MSE D 102                 N   ASP D 103     1555   1555  1.34
LINK         C   THR D 146                 N   MSE D 147     1555   1555  1.33
LINK         C   MSE D 147                 N   TYR D 148     1555   1555  1.34
LINK         C   THR D 174                 N   MSE D 175     1555   1555  1.32
LINK         C   MSE D 175                 N   ILE D 176     1555   1555  1.34
LINK         C   GLU D 214                 N   MSE D 215     1555   1555  1.33
LINK         C   MSE D 215                 N   ILE D 216     1555   1555  1.32
LINK         OE2 GLU B 268                CA    CA B 401     1555   1555  2.26
LINK         OE1 GLU B 268                CA    CA B 401     1555   1555  2.27
LINK         OE1 GLU A 268                CA    CA A 401     1555   1555  2.27
LINK         OE2 GLU A 268                CA    CA A 401     1555   1555  2.27
LINK         OE2 GLU C 205                CA    CA C 402     1555   1555  2.30
LINK         OD1 ASN C  49                CA    CA C 402     1555   1555  2.32
LINK         O   SER D 189                CA    CA D 401     1555   1555  2.32
LINK         O   THR A 238                CA    CA A 401     1555   1555  2.32
LINK         O   THR B 238                CA    CA B 401     1555   1555  2.33
LINK         O   LEU D 192                CA    CA D 401     1555   1555  2.33
LINK         OG1 THR B 238                CA    CA B 401     1555   1555  2.33
LINK         O   LEU C 192                CA    CA C 401     1555   1555  2.33
LINK         OG1 THR A 238                CA    CA A 401     1555   1555  2.34
LINK         O   SER C 189                CA    CA C 401     1555   1555  2.34
LINK        CA    CA D 401                 O   HOH D 610     1555   1555  2.12
LINK        CA    CA C 401                 O   HOH C 516     1555   1555  2.24
LINK        CA    CA A 401                 O   HOH A 633     1555   1555  2.39
LINK        CA    CA A 401                 O  AHOH A 631     1555   1555  2.39
LINK        CA    CA B 401                 O   HOH B 654     1555   1555  2.43
LINK        CA    CA C 401                 O   HOH C 632     1555   1555  2.44
LINK        CA    CA A 401                 O   HOH A 632     1555   1555  2.46
LINK        CA    CA B 401                 O   HOH B 586     1555   1555  2.50
LINK        CA    CA D 401                 O   HOH D 573     1555   1555  2.50
LINK        CA    CA A 401                 O   HOH A 598     1555   1555  2.51
LINK        CA    CA B 401                 O   HOH B 644     1555   1555  2.56
LINK        CA    CA B 401                 O   HOH B 652     1555   1555  2.59
LINK        CA    CA C 402                 O   HOH C 554     1555   1555  2.71
LINK        CA    CA A 401                 O  BHOH A 631     1555   1555  3.13
CISPEP   1 HIS A   46    PRO A   47          0        -0.22
CISPEP   2 PHE A  169    PRO A  170          0         2.20
CISPEP   3 HIS B   46    PRO B   47          0        -1.99
CISPEP   4 PHE B  169    PRO B  170          0         2.50
CISPEP   5 HIS C   46    PRO C   47          0        -0.26
CISPEP   6 PHE C  169    PRO C  170          0         0.87
CISPEP   7 HIS D   46    PRO D   47          0        -0.08
CISPEP   8 PHE D  169    PRO D  170          0        -0.05
SITE     1 AC1  6 THR A 238  GLU A 268  HOH A 598  HOH A 631
SITE     2 AC1  6 HOH A 632  HOH A 633
SITE     1 AC2  3 ASP A 116  ARG A 117  ARG A 120
SITE     1 AC3  6 THR B 238  GLU B 268  HOH B 586  HOH B 644
SITE     2 AC3  6 HOH B 652  HOH B 654
SITE     1 AC4  3 ASP B 116  ARG B 117  ARG B 120
SITE     1 AC5  5 SER C 189  LEU C 192  GLU C 195  HOH C 516
SITE     2 AC5  5 HOH C 632
SITE     1 AC6  5 ASN C  49  HIS C  50  THR C  51  GLU C 205
SITE     2 AC6  5 HOH C 554
SITE     1 AC7  4 SER D 189  LEU D 192  HOH D 573  HOH D 610
CRYST1   47.931   71.380   90.327 113.03  92.41  90.09 P 1           4
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.020863  0.000034  0.000968        0.00000
SCALE2      0.000000  0.014010  0.005963        0.00000
SCALE3      0.000000  0.000000  0.012043        0.00000
TER    2459      LEU A 304
TER    4846      LEU B 304
TER    7248      LEU C 304
TER    9616      LEU D 304
MASTER      765    0   31   68   36    0   11    610086    4  278   96
END