longtext: 4OYY-pdb

content
HEADER    HYDROLASE                               13-FEB-14   4OYY
TITLE     HUMICOLA INSOLENS CUTINASE
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: CUTINASE;
COMPND   3 CHAIN: A, B, C, D, E, F, G, H, I, J, K, L;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: HUMICOLA INSOLENS;
SOURCE   3 ORGANISM_TAXID: 34413;
SOURCE   4 EXPRESSION_SYSTEM: ASPERGILLUS ORYZAE;
SOURCE   5 EXPRESSION_SYSTEM_TAXID: 5062
KEYWDS    HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    Z.D.DAUTER,A.M.BRZOZOWSKI,J.P.TURKENBURG,K.S.WILSON
REVDAT   1   30-JUL-14 4OYY    0
JRNL        AUTH   D.KOLD,Z.DAUTER,A.K.LAUSTSEN,A.M.BRZOZOWSKI,J.P.TURKENBURG,
JRNL        AUTH 2 A.D.NIELSEN,H.KOLDS,E.PETERSEN,B.SCHITT,L.DE MARIA,
JRNL        AUTH 3 K.S.WILSON,A.SVENDSEN,R.WIMMER
JRNL        TITL   THERMODYNAMIC AND STRUCTURAL INVESTIGATION OF THE SPECIFIC
JRNL        TITL 2 SDS BINDING OF HUMICOLA INSOLENS CUTINASE.
JRNL        REF    PROTEIN SCI.                  V.  23  1023 2014
JRNL        REFN                   ESSN 1469-896X
JRNL        PMID   24832484
JRNL        DOI    10.1002/PRO.2489
REMARK   2
REMARK   2 RESOLUTION.    3.00 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.8.0049
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 3.00
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 29.76
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.4
REMARK   3   NUMBER OF REFLECTIONS             : 42118
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.175
REMARK   3   R VALUE            (WORKING SET) : 0.174
REMARK   3   FREE R VALUE                     : 0.196
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 3.100
REMARK   3   FREE R VALUE TEST SET COUNT      : 1338
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 3.00
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 3.08
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 3010
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 97.31
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2620
REMARK   3   BIN FREE R VALUE SET COUNT          : 96
REMARK   3   BIN FREE R VALUE                    : 0.2850
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 16877
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 0
REMARK   3   SOLVENT ATOMS            : 98
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 27.82
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -1.05000
REMARK   3    B22 (A**2) : 2.39000
REMARK   3    B33 (A**2) : -1.34000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): NULL
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.378
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.276
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 15.789
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.957
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.957
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A): 17189 ; 0.011 ; 0.019
REMARK   3   BOND LENGTHS OTHERS               (A): 16543 ; 0.008 ; 0.020
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 23355 ; 1.445 ; 1.959
REMARK   3   BOND ANGLES OTHERS          (DEGREES): 37829 ; 1.539 ; 3.000
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  2289 ; 5.624 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   731 ;36.083 ;23.844
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  2624 ;16.371 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):   141 ;16.258 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  2630 ; 0.084 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A): 20270 ; 0.008 ; 0.021
REMARK   3   GENERAL PLANES OTHERS             (A):  3987 ; 0.006 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  9192 ; 1.757 ; 2.617
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  9191 ; 1.756 ; 2.617
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2): 11469 ; 2.917 ; 3.924
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2): 11470 ; 2.918 ; 3.924
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  7997 ; 2.312 ; 2.925
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2):  7998 ; 2.312 ; 2.926
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2): 11887 ; 3.869 ; 4.271
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2): 18530 ; 5.390 ;20.771
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2): 18531 ; 5.390 ;20.773
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NCS TYPE: LOCAL
REMARK   3   NUMBER OF DIFFERENT NCS PAIRS  : 66
REMARK   3  GROUP  CHAIN1    RANGE     CHAIN2     RANGE    COUNT RMS  WEIGHT
REMARK   3    1     A     3    193       B     3    193   11229  0.07  0.05
REMARK   3    2     A     3    192       C     3    192   11032  0.07  0.05
REMARK   3    3     A     3    193       D     3    193   11457  0.05  0.05
REMARK   3    4     A     3    193       E     3    193   11074  0.07  0.05
REMARK   3    5     A     3    192       F     3    192   11069  0.07  0.05
REMARK   3    6     A     3    192       G     3    192   11234  0.06  0.05
REMARK   3    7     A     3    193       H     3    193   11337  0.06  0.05
REMARK   3    8     A     3    192       I     3    192   11051  0.06  0.05
REMARK   3    9     A     3    193       J     3    193   11380  0.06  0.05
REMARK   3   10     A     3    193       K     3    193   11244  0.06  0.05
REMARK   3   11     A     3    192       L     3    192   11035  0.08  0.05
REMARK   3   12     B     3    192       C     3    192   10906  0.08  0.05
REMARK   3   13     B     3    193       D     3    193   11228  0.07  0.05
REMARK   3   14     B     3    193       E     3    193   11103  0.08  0.05
REMARK   3   15     B     3    192       F     3    192   10953  0.08  0.05
REMARK   3   16     B     3    192       G     3    192   11015  0.08  0.05
REMARK   3   17     B     3    193       H     3    193   11358  0.06  0.05
REMARK   3   18     B     3    192       I     3    192   10892  0.07  0.05
REMARK   3   19     B     3    193       J     3    193   11144  0.08  0.05
REMARK   3   20     B     3    193       K     3    193   11276  0.06  0.05
REMARK   3   21     B     3    192       L     3    192   10938  0.09  0.05
REMARK   3   22     C     3    192       D     3    192   11018  0.07  0.05
REMARK   3   23     C     3    192       E     3    192   10864  0.08  0.05
REMARK   3   24     C     1    193       F     1    193   11392  0.06  0.05
REMARK   3   25     C     1    193       G     1    193   11237  0.07  0.05
REMARK   3   26     C     3    192       H     3    192   10955  0.08  0.05
REMARK   3   27     C     1    193       I     1    193   11180  0.07  0.05
REMARK   3   28     C     3    192       J     3    192   11039  0.07  0.05
REMARK   3   29     C     3    192       K     3    192   11005  0.07  0.05
REMARK   3   30     C     2    192       L     2    192   11165  0.08  0.05
REMARK   3   31     D     3    193       E     3    193   11063  0.07  0.05
REMARK   3   32     D     3    192       F     3    192   11086  0.06  0.05
REMARK   3   33     D     3    192       G     3    192   11198  0.06  0.05
REMARK   3   34     D     3    193       H     3    193   11294  0.06  0.05
REMARK   3   35     D     3    192       I     3    192   11035  0.06  0.05
REMARK   3   36     D     3    193       J     3    193   11337  0.07  0.05
REMARK   3   37     D     3    193       K     3    193   11235  0.06  0.05
REMARK   3   38     D     3    192       L     3    192   11017  0.08  0.05
REMARK   3   39     E     3    192       F     3    192   10860  0.08  0.05
REMARK   3   40     E     3    192       G     3    192   10944  0.07  0.05
REMARK   3   41     E     3    193       H     3    193   11114  0.07  0.05
REMARK   3   42     E     3    192       I     3    192   10782  0.08  0.05
REMARK   3   43     E     3    193       J     3    193   11063  0.07  0.05
REMARK   3   44     E     3    193       K     3    193   11106  0.07  0.05
REMARK   3   45     E     3    192       L     3    192   10872  0.09  0.05
REMARK   3   46     F     1    193       G     1    193   11233  0.07  0.05
REMARK   3   47     F     3    192       H     3    192   11004  0.08  0.05
REMARK   3   48     F     1    193       I     1    193   11286  0.06  0.05
REMARK   3   49     F     3    192       J     3    192   11039  0.07  0.05
REMARK   3   50     F     3    192       K     3    192   11025  0.07  0.05
REMARK   3   51     F     2    192       L     2    192   11188  0.08  0.05
REMARK   3   52     G     3    192       H     3    192   11094  0.07  0.05
REMARK   3   53     G     1    193       I     1    193   11177  0.07  0.05
REMARK   3   54     G     3    192       J     3    192   11210  0.05  0.05
REMARK   3   55     G     3    192       K     3    192   11065  0.06  0.05
REMARK   3   56     G     2    192       L     2    192   11107  0.08  0.05
REMARK   3   57     H     3    192       I     3    192   10945  0.07  0.05
REMARK   3   58     H     3    193       J     3    193   11261  0.07  0.05
REMARK   3   59     H     3    193       K     3    193   11350  0.05  0.05
REMARK   3   60     H     3    192       L     3    192   10971  0.09  0.05
REMARK   3   61     I     3    192       J     3    192   10954  0.07  0.05
REMARK   3   62     I     3    192       K     3    192   11121  0.05  0.05
REMARK   3   63     I     2    192       L     2    192   11042  0.08  0.05
REMARK   3   64     J     3    193       K     3    193   11196  0.07  0.05
REMARK   3   65     J     3    192       L     3    192   11101  0.07  0.05
REMARK   3   66     K     3    192       L     3    192   11032  0.08  0.05
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING
REMARK   3  POSITIONS
REMARK   4
REMARK   4 4OYY COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 27-FEB-14.
REMARK 100 THE DEPOSITION ID IS D_1000200280.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 20-JUN-95
REMARK 200  TEMPERATURE           (KELVIN) : 120
REMARK 200  PH                             : 8.5
REMARK 200  NUMBER OF CRYSTALS USED        : NULL
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : N
REMARK 200  RADIATION SOURCE               : ROTATING ANODE
REMARK 200  BEAMLINE                       : NULL
REMARK 200  X-RAY GENERATOR MODEL          : RIGAKU RU200
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : NULL
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.54
REMARK 200  MONOCHROMATOR                  : MIRRORS
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : IMAGE PLATE
REMARK 200  DETECTOR MANUFACTURER          : RIGAKU RAXIS II
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : NULL
REMARK 200  DATA SCALING SOFTWARE          : NULL
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 43738
REMARK 200  RESOLUTION RANGE HIGH      (A) : 3.000
REMARK 200  RESOLUTION RANGE LOW       (A) : 30.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.5
REMARK 200  DATA REDUNDANCY                : 4.500
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 5.9000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.00
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 3.16
REMARK 200  COMPLETENESS FOR SHELL     (%) : 97.5
REMARK 200  DATA REDUNDANCY IN SHELL       : 3.60
REMARK 200  R MERGE FOR SHELL          (I) : 0.32400
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 2.300
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: NULL
REMARK 200 SOFTWARE USED: NULL
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 44.20
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.20
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: HICUTINASE 30 MG ML-1, 0.1 M TRIS/HCL
REMARK 280  BUFFER PH 8.5, 50 MM LYSINE, 100 MG ML-1 (APP. 8.6%) ISOPROPANOL,
REMARK 280  50 MG ML-1 (APP. 4.3 %) DIOXANE, PEG 4K 22% V/V OF 50% W/V
REMARK 280  STOCK SOLUTIONS
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X+1/2,-Y,Z+1/2
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       62.77400
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       67.25250
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       63.49950
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       67.25250
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       62.77400
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       63.49950
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 3
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 4
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 5
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: E
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 6
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: F
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 7
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: G
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 8
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: H
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 9
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: I
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 10
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: J
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 11
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: K
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 12
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: L
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     GLN A     1
REMARK 465     LEU A     2
REMARK 465     ALA A   194
REMARK 465     GLN B     1
REMARK 465     LEU B     2
REMARK 465     ALA B   194
REMARK 465     ALA C   194
REMARK 465     GLN D     1
REMARK 465     LEU D     2
REMARK 465     ALA D   194
REMARK 465     GLN E     1
REMARK 465     LEU E     2
REMARK 465     ALA E   194
REMARK 465     ALA F   194
REMARK 465     ALA G   194
REMARK 465     GLN H     1
REMARK 465     LEU H     2
REMARK 465     ALA H   194
REMARK 465     ALA I   194
REMARK 465     GLN J     1
REMARK 465     LEU J     2
REMARK 465     ALA J   194
REMARK 465     GLN K     1
REMARK 465     LEU K     2
REMARK 465     ALA K   194
REMARK 465     GLN L     1
REMARK 465     ALA L   194
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     ARG B 141    CD   NE   CZ   NH1  NH2
REMARK 470     ARG E 141    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU G  47    CD   OE1  OE2
REMARK 470     ASN I  15    CG   OD1  ND2
REMARK 470     ARG I 149    CG   CD   NE   CZ   NH1  NH2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    ARG A  51   NE  -  CZ  -  NH1 ANGL. DEV. =   3.9 DEGREES
REMARK 500    ARG A 181   NE  -  CZ  -  NH1 ANGL. DEV. =   3.0 DEGREES
REMARK 500    MET B  34   CG  -  SD  -  CE  ANGL. DEV. = -17.2 DEGREES
REMARK 500    ARG C  51   NE  -  CZ  -  NH1 ANGL. DEV. =   3.2 DEGREES
REMARK 500    ARG C 141   NE  -  CZ  -  NH1 ANGL. DEV. =   3.1 DEGREES
REMARK 500    ALA E   4   N   -  CA  -  CB  ANGL. DEV. =  13.0 DEGREES
REMARK 500    ARG F  51   NE  -  CZ  -  NH1 ANGL. DEV. =   3.2 DEGREES
REMARK 500    ARG G  51   NE  -  CZ  -  NH1 ANGL. DEV. =   3.8 DEGREES
REMARK 500    ILE G 192   CA  -  CB  -  CG1 ANGL. DEV. =  14.4 DEGREES
REMARK 500    LEU H 167   CB  -  CG  -  CD1 ANGL. DEV. =  11.4 DEGREES
REMARK 500    ARG H 186   CD  -  NE  -  CZ  ANGL. DEV. =   9.0 DEGREES
REMARK 500    ARG H 186   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.7 DEGREES
REMARK 500    ARG H 193   NE  -  CZ  -  NH1 ANGL. DEV. =   3.1 DEGREES
REMARK 500    ARG J  51   NE  -  CZ  -  NH1 ANGL. DEV. =   3.9 DEGREES
REMARK 500    ARG J  73   N   -  CA  -  CB  ANGL. DEV. = -11.0 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    THR A  29       -1.05     72.38
REMARK 500    THR A  37      -91.19   -110.89
REMARK 500    ARG A  73       -3.82     84.15
REMARK 500    SER A 105     -124.36     57.64
REMARK 500    THR B  29       -1.41     74.48
REMARK 500    THR B  37      -90.53   -110.47
REMARK 500    ARG B  73       -3.35     84.56
REMARK 500    SER B 105     -123.28     56.38
REMARK 500    ALA C   4      -11.85   -141.30
REMARK 500    THR C  29       -0.23     73.13
REMARK 500    THR C  37      -92.79   -110.37
REMARK 500    ARG C  73       -2.63     84.92
REMARK 500    SER C 105     -123.23     56.88
REMARK 500    THR D  37      -91.06   -110.64
REMARK 500    ARG D  73       -3.67     85.69
REMARK 500    SER D 105     -122.95     56.69
REMARK 500    ALA E   4      -31.23    148.78
REMARK 500    THR E  29       -0.43     72.14
REMARK 500    THR E  37      -91.47   -110.41
REMARK 500    ARG E  73       -3.23     84.07
REMARK 500    SER E 105     -123.25     57.61
REMARK 500    THR F  37      -92.25   -109.67
REMARK 500    ARG F  73       -2.84     84.52
REMARK 500    SER F 105     -122.64     56.23
REMARK 500    THR G  37      -91.44   -110.56
REMARK 500    ARG G  73       -3.55     84.17
REMARK 500    SER G 105     -124.04     57.69
REMARK 500    THR H  29       -1.89     73.91
REMARK 500    THR H  37      -91.44   -110.59
REMARK 500    ARG H  73       -3.87     84.64
REMARK 500    SER H 105     -122.82     57.79
REMARK 500    THR I  37      -92.63   -109.76
REMARK 500    ARG I  73       -2.47     85.21
REMARK 500    SER I 105     -123.83     57.08
REMARK 500    THR J  29       -7.44     78.12
REMARK 500    THR J  37      -91.02   -110.26
REMARK 500    SER J 105     -123.92     58.44
REMARK 500    THR K  29       -0.95     72.93
REMARK 500    THR K  37      -91.32   -110.56
REMARK 500    ARG K  73       -3.02     84.66
REMARK 500    SER K 105     -123.12     58.30
REMARK 500    THR L  29       -0.05     72.38
REMARK 500    THR L  37      -92.27   -110.39
REMARK 500    SER L 105     -123.19     56.85
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500                                 MODEL     OMEGA
REMARK 500 GLN C    1     LEU C    2                 -144.00
REMARK 500 GLY C    3     ALA C    4                  -43.42
REMARK 500
REMARK 500 REMARK: NULL
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 4OYL   RELATED DB: PDB
REMARK 900 CUTINASE COMPLEXED WITH MONOETHYLPHOSPHATE
DBREF  4OYY A    1   194  PDB    PDB      4OYY             1    194
DBREF  4OYY B    1   194  PDB    PDB      4OYY             1    194
DBREF  4OYY C    1   194  PDB    PDB      4OYY             1    194
DBREF  4OYY D    1   194  PDB    PDB      4OYY             1    194
DBREF  4OYY E    1   194  PDB    PDB      4OYY             1    194
DBREF  4OYY F    1   194  PDB    PDB      4OYY             1    194
DBREF  4OYY G    1   194  PDB    PDB      4OYY             1    194
DBREF  4OYY H    1   194  PDB    PDB      4OYY             1    194
DBREF  4OYY I    1   194  PDB    PDB      4OYY             1    194
DBREF  4OYY J    1   194  PDB    PDB      4OYY             1    194
DBREF  4OYY K    1   194  PDB    PDB      4OYY             1    194
DBREF  4OYY L    1   194  PDB    PDB      4OYY             1    194
SEQRES   1 A  194  GLN LEU GLY ALA ILE GLU ASN GLY LEU GLU SER GLY SER
SEQRES   2 A  194  ALA ASN ALA CYS PRO ASP ALA ILE LEU ILE PHE ALA ARG
SEQRES   3 A  194  GLY SER THR GLU PRO GLY ASN MET GLY ILE THR VAL GLY
SEQRES   4 A  194  PRO ALA LEU ALA ASN GLY LEU GLU SER HIS ILE ARG ASN
SEQRES   5 A  194  ILE TRP ILE GLN GLY VAL GLY GLY PRO TYR ASP ALA ALA
SEQRES   6 A  194  LEU ALA THR ASN PHE LEU PRO ARG GLY THR SER GLN ALA
SEQRES   7 A  194  ASN ILE ASP GLU GLY LYS ARG LEU PHE ALA LEU ALA ASN
SEQRES   8 A  194  GLN LYS CYS PRO ASN THR PRO VAL VAL ALA GLY GLY TYR
SEQRES   9 A  194  SER GLN GLY ALA ALA LEU ILE ALA ALA ALA VAL SER GLU
SEQRES  10 A  194  LEU SER GLY ALA VAL LYS GLU GLN VAL LYS GLY VAL ALA
SEQRES  11 A  194  LEU PHE GLY TYR THR GLN ASN LEU GLN ASN ARG GLY GLY
SEQRES  12 A  194  ILE PRO ASN TYR PRO ARG GLU ARG THR LYS VAL PHE CYS
SEQRES  13 A  194  ASN VAL GLY ASP ALA VAL CYS THR GLY THR LEU ILE ILE
SEQRES  14 A  194  THR PRO ALA HIS LEU SER TYR THR ILE GLU ALA ARG GLY
SEQRES  15 A  194  GLU ALA ALA ARG PHE LEU ARG ASP ARG ILE ARG ALA
SEQRES   1 B  194  GLN LEU GLY ALA ILE GLU ASN GLY LEU GLU SER GLY SER
SEQRES   2 B  194  ALA ASN ALA CYS PRO ASP ALA ILE LEU ILE PHE ALA ARG
SEQRES   3 B  194  GLY SER THR GLU PRO GLY ASN MET GLY ILE THR VAL GLY
SEQRES   4 B  194  PRO ALA LEU ALA ASN GLY LEU GLU SER HIS ILE ARG ASN
SEQRES   5 B  194  ILE TRP ILE GLN GLY VAL GLY GLY PRO TYR ASP ALA ALA
SEQRES   6 B  194  LEU ALA THR ASN PHE LEU PRO ARG GLY THR SER GLN ALA
SEQRES   7 B  194  ASN ILE ASP GLU GLY LYS ARG LEU PHE ALA LEU ALA ASN
SEQRES   8 B  194  GLN LYS CYS PRO ASN THR PRO VAL VAL ALA GLY GLY TYR
SEQRES   9 B  194  SER GLN GLY ALA ALA LEU ILE ALA ALA ALA VAL SER GLU
SEQRES  10 B  194  LEU SER GLY ALA VAL LYS GLU GLN VAL LYS GLY VAL ALA
SEQRES  11 B  194  LEU PHE GLY TYR THR GLN ASN LEU GLN ASN ARG GLY GLY
SEQRES  12 B  194  ILE PRO ASN TYR PRO ARG GLU ARG THR LYS VAL PHE CYS
SEQRES  13 B  194  ASN VAL GLY ASP ALA VAL CYS THR GLY THR LEU ILE ILE
SEQRES  14 B  194  THR PRO ALA HIS LEU SER TYR THR ILE GLU ALA ARG GLY
SEQRES  15 B  194  GLU ALA ALA ARG PHE LEU ARG ASP ARG ILE ARG ALA
SEQRES   1 C  194  GLN LEU GLY ALA ILE GLU ASN GLY LEU GLU SER GLY SER
SEQRES   2 C  194  ALA ASN ALA CYS PRO ASP ALA ILE LEU ILE PHE ALA ARG
SEQRES   3 C  194  GLY SER THR GLU PRO GLY ASN MET GLY ILE THR VAL GLY
SEQRES   4 C  194  PRO ALA LEU ALA ASN GLY LEU GLU SER HIS ILE ARG ASN
SEQRES   5 C  194  ILE TRP ILE GLN GLY VAL GLY GLY PRO TYR ASP ALA ALA
SEQRES   6 C  194  LEU ALA THR ASN PHE LEU PRO ARG GLY THR SER GLN ALA
SEQRES   7 C  194  ASN ILE ASP GLU GLY LYS ARG LEU PHE ALA LEU ALA ASN
SEQRES   8 C  194  GLN LYS CYS PRO ASN THR PRO VAL VAL ALA GLY GLY TYR
SEQRES   9 C  194  SER GLN GLY ALA ALA LEU ILE ALA ALA ALA VAL SER GLU
SEQRES  10 C  194  LEU SER GLY ALA VAL LYS GLU GLN VAL LYS GLY VAL ALA
SEQRES  11 C  194  LEU PHE GLY TYR THR GLN ASN LEU GLN ASN ARG GLY GLY
SEQRES  12 C  194  ILE PRO ASN TYR PRO ARG GLU ARG THR LYS VAL PHE CYS
SEQRES  13 C  194  ASN VAL GLY ASP ALA VAL CYS THR GLY THR LEU ILE ILE
SEQRES  14 C  194  THR PRO ALA HIS LEU SER TYR THR ILE GLU ALA ARG GLY
SEQRES  15 C  194  GLU ALA ALA ARG PHE LEU ARG ASP ARG ILE ARG ALA
SEQRES   1 D  194  GLN LEU GLY ALA ILE GLU ASN GLY LEU GLU SER GLY SER
SEQRES   2 D  194  ALA ASN ALA CYS PRO ASP ALA ILE LEU ILE PHE ALA ARG
SEQRES   3 D  194  GLY SER THR GLU PRO GLY ASN MET GLY ILE THR VAL GLY
SEQRES   4 D  194  PRO ALA LEU ALA ASN GLY LEU GLU SER HIS ILE ARG ASN
SEQRES   5 D  194  ILE TRP ILE GLN GLY VAL GLY GLY PRO TYR ASP ALA ALA
SEQRES   6 D  194  LEU ALA THR ASN PHE LEU PRO ARG GLY THR SER GLN ALA
SEQRES   7 D  194  ASN ILE ASP GLU GLY LYS ARG LEU PHE ALA LEU ALA ASN
SEQRES   8 D  194  GLN LYS CYS PRO ASN THR PRO VAL VAL ALA GLY GLY TYR
SEQRES   9 D  194  SER GLN GLY ALA ALA LEU ILE ALA ALA ALA VAL SER GLU
SEQRES  10 D  194  LEU SER GLY ALA VAL LYS GLU GLN VAL LYS GLY VAL ALA
SEQRES  11 D  194  LEU PHE GLY TYR THR GLN ASN LEU GLN ASN ARG GLY GLY
SEQRES  12 D  194  ILE PRO ASN TYR PRO ARG GLU ARG THR LYS VAL PHE CYS
SEQRES  13 D  194  ASN VAL GLY ASP ALA VAL CYS THR GLY THR LEU ILE ILE
SEQRES  14 D  194  THR PRO ALA HIS LEU SER TYR THR ILE GLU ALA ARG GLY
SEQRES  15 D  194  GLU ALA ALA ARG PHE LEU ARG ASP ARG ILE ARG ALA
SEQRES   1 E  194  GLN LEU GLY ALA ILE GLU ASN GLY LEU GLU SER GLY SER
SEQRES   2 E  194  ALA ASN ALA CYS PRO ASP ALA ILE LEU ILE PHE ALA ARG
SEQRES   3 E  194  GLY SER THR GLU PRO GLY ASN MET GLY ILE THR VAL GLY
SEQRES   4 E  194  PRO ALA LEU ALA ASN GLY LEU GLU SER HIS ILE ARG ASN
SEQRES   5 E  194  ILE TRP ILE GLN GLY VAL GLY GLY PRO TYR ASP ALA ALA
SEQRES   6 E  194  LEU ALA THR ASN PHE LEU PRO ARG GLY THR SER GLN ALA
SEQRES   7 E  194  ASN ILE ASP GLU GLY LYS ARG LEU PHE ALA LEU ALA ASN
SEQRES   8 E  194  GLN LYS CYS PRO ASN THR PRO VAL VAL ALA GLY GLY TYR
SEQRES   9 E  194  SER GLN GLY ALA ALA LEU ILE ALA ALA ALA VAL SER GLU
SEQRES  10 E  194  LEU SER GLY ALA VAL LYS GLU GLN VAL LYS GLY VAL ALA
SEQRES  11 E  194  LEU PHE GLY TYR THR GLN ASN LEU GLN ASN ARG GLY GLY
SEQRES  12 E  194  ILE PRO ASN TYR PRO ARG GLU ARG THR LYS VAL PHE CYS
SEQRES  13 E  194  ASN VAL GLY ASP ALA VAL CYS THR GLY THR LEU ILE ILE
SEQRES  14 E  194  THR PRO ALA HIS LEU SER TYR THR ILE GLU ALA ARG GLY
SEQRES  15 E  194  GLU ALA ALA ARG PHE LEU ARG ASP ARG ILE ARG ALA
SEQRES   1 F  194  GLN LEU GLY ALA ILE GLU ASN GLY LEU GLU SER GLY SER
SEQRES   2 F  194  ALA ASN ALA CYS PRO ASP ALA ILE LEU ILE PHE ALA ARG
SEQRES   3 F  194  GLY SER THR GLU PRO GLY ASN MET GLY ILE THR VAL GLY
SEQRES   4 F  194  PRO ALA LEU ALA ASN GLY LEU GLU SER HIS ILE ARG ASN
SEQRES   5 F  194  ILE TRP ILE GLN GLY VAL GLY GLY PRO TYR ASP ALA ALA
SEQRES   6 F  194  LEU ALA THR ASN PHE LEU PRO ARG GLY THR SER GLN ALA
SEQRES   7 F  194  ASN ILE ASP GLU GLY LYS ARG LEU PHE ALA LEU ALA ASN
SEQRES   8 F  194  GLN LYS CYS PRO ASN THR PRO VAL VAL ALA GLY GLY TYR
SEQRES   9 F  194  SER GLN GLY ALA ALA LEU ILE ALA ALA ALA VAL SER GLU
SEQRES  10 F  194  LEU SER GLY ALA VAL LYS GLU GLN VAL LYS GLY VAL ALA
SEQRES  11 F  194  LEU PHE GLY TYR THR GLN ASN LEU GLN ASN ARG GLY GLY
SEQRES  12 F  194  ILE PRO ASN TYR PRO ARG GLU ARG THR LYS VAL PHE CYS
SEQRES  13 F  194  ASN VAL GLY ASP ALA VAL CYS THR GLY THR LEU ILE ILE
SEQRES  14 F  194  THR PRO ALA HIS LEU SER TYR THR ILE GLU ALA ARG GLY
SEQRES  15 F  194  GLU ALA ALA ARG PHE LEU ARG ASP ARG ILE ARG ALA
SEQRES   1 G  194  GLN LEU GLY ALA ILE GLU ASN GLY LEU GLU SER GLY SER
SEQRES   2 G  194  ALA ASN ALA CYS PRO ASP ALA ILE LEU ILE PHE ALA ARG
SEQRES   3 G  194  GLY SER THR GLU PRO GLY ASN MET GLY ILE THR VAL GLY
SEQRES   4 G  194  PRO ALA LEU ALA ASN GLY LEU GLU SER HIS ILE ARG ASN
SEQRES   5 G  194  ILE TRP ILE GLN GLY VAL GLY GLY PRO TYR ASP ALA ALA
SEQRES   6 G  194  LEU ALA THR ASN PHE LEU PRO ARG GLY THR SER GLN ALA
SEQRES   7 G  194  ASN ILE ASP GLU GLY LYS ARG LEU PHE ALA LEU ALA ASN
SEQRES   8 G  194  GLN LYS CYS PRO ASN THR PRO VAL VAL ALA GLY GLY TYR
SEQRES   9 G  194  SER GLN GLY ALA ALA LEU ILE ALA ALA ALA VAL SER GLU
SEQRES  10 G  194  LEU SER GLY ALA VAL LYS GLU GLN VAL LYS GLY VAL ALA
SEQRES  11 G  194  LEU PHE GLY TYR THR GLN ASN LEU GLN ASN ARG GLY GLY
SEQRES  12 G  194  ILE PRO ASN TYR PRO ARG GLU ARG THR LYS VAL PHE CYS
SEQRES  13 G  194  ASN VAL GLY ASP ALA VAL CYS THR GLY THR LEU ILE ILE
SEQRES  14 G  194  THR PRO ALA HIS LEU SER TYR THR ILE GLU ALA ARG GLY
SEQRES  15 G  194  GLU ALA ALA ARG PHE LEU ARG ASP ARG ILE ARG ALA
SEQRES   1 H  194  GLN LEU GLY ALA ILE GLU ASN GLY LEU GLU SER GLY SER
SEQRES   2 H  194  ALA ASN ALA CYS PRO ASP ALA ILE LEU ILE PHE ALA ARG
SEQRES   3 H  194  GLY SER THR GLU PRO GLY ASN MET GLY ILE THR VAL GLY
SEQRES   4 H  194  PRO ALA LEU ALA ASN GLY LEU GLU SER HIS ILE ARG ASN
SEQRES   5 H  194  ILE TRP ILE GLN GLY VAL GLY GLY PRO TYR ASP ALA ALA
SEQRES   6 H  194  LEU ALA THR ASN PHE LEU PRO ARG GLY THR SER GLN ALA
SEQRES   7 H  194  ASN ILE ASP GLU GLY LYS ARG LEU PHE ALA LEU ALA ASN
SEQRES   8 H  194  GLN LYS CYS PRO ASN THR PRO VAL VAL ALA GLY GLY TYR
SEQRES   9 H  194  SER GLN GLY ALA ALA LEU ILE ALA ALA ALA VAL SER GLU
SEQRES  10 H  194  LEU SER GLY ALA VAL LYS GLU GLN VAL LYS GLY VAL ALA
SEQRES  11 H  194  LEU PHE GLY TYR THR GLN ASN LEU GLN ASN ARG GLY GLY
SEQRES  12 H  194  ILE PRO ASN TYR PRO ARG GLU ARG THR LYS VAL PHE CYS
SEQRES  13 H  194  ASN VAL GLY ASP ALA VAL CYS THR GLY THR LEU ILE ILE
SEQRES  14 H  194  THR PRO ALA HIS LEU SER TYR THR ILE GLU ALA ARG GLY
SEQRES  15 H  194  GLU ALA ALA ARG PHE LEU ARG ASP ARG ILE ARG ALA
SEQRES   1 I  194  GLN LEU GLY ALA ILE GLU ASN GLY LEU GLU SER GLY SER
SEQRES   2 I  194  ALA ASN ALA CYS PRO ASP ALA ILE LEU ILE PHE ALA ARG
SEQRES   3 I  194  GLY SER THR GLU PRO GLY ASN MET GLY ILE THR VAL GLY
SEQRES   4 I  194  PRO ALA LEU ALA ASN GLY LEU GLU SER HIS ILE ARG ASN
SEQRES   5 I  194  ILE TRP ILE GLN GLY VAL GLY GLY PRO TYR ASP ALA ALA
SEQRES   6 I  194  LEU ALA THR ASN PHE LEU PRO ARG GLY THR SER GLN ALA
SEQRES   7 I  194  ASN ILE ASP GLU GLY LYS ARG LEU PHE ALA LEU ALA ASN
SEQRES   8 I  194  GLN LYS CYS PRO ASN THR PRO VAL VAL ALA GLY GLY TYR
SEQRES   9 I  194  SER GLN GLY ALA ALA LEU ILE ALA ALA ALA VAL SER GLU
SEQRES  10 I  194  LEU SER GLY ALA VAL LYS GLU GLN VAL LYS GLY VAL ALA
SEQRES  11 I  194  LEU PHE GLY TYR THR GLN ASN LEU GLN ASN ARG GLY GLY
SEQRES  12 I  194  ILE PRO ASN TYR PRO ARG GLU ARG THR LYS VAL PHE CYS
SEQRES  13 I  194  ASN VAL GLY ASP ALA VAL CYS THR GLY THR LEU ILE ILE
SEQRES  14 I  194  THR PRO ALA HIS LEU SER TYR THR ILE GLU ALA ARG GLY
SEQRES  15 I  194  GLU ALA ALA ARG PHE LEU ARG ASP ARG ILE ARG ALA
SEQRES   1 J  194  GLN LEU GLY ALA ILE GLU ASN GLY LEU GLU SER GLY SER
SEQRES   2 J  194  ALA ASN ALA CYS PRO ASP ALA ILE LEU ILE PHE ALA ARG
SEQRES   3 J  194  GLY SER THR GLU PRO GLY ASN MET GLY ILE THR VAL GLY
SEQRES   4 J  194  PRO ALA LEU ALA ASN GLY LEU GLU SER HIS ILE ARG ASN
SEQRES   5 J  194  ILE TRP ILE GLN GLY VAL GLY GLY PRO TYR ASP ALA ALA
SEQRES   6 J  194  LEU ALA THR ASN PHE LEU PRO ARG GLY THR SER GLN ALA
SEQRES   7 J  194  ASN ILE ASP GLU GLY LYS ARG LEU PHE ALA LEU ALA ASN
SEQRES   8 J  194  GLN LYS CYS PRO ASN THR PRO VAL VAL ALA GLY GLY TYR
SEQRES   9 J  194  SER GLN GLY ALA ALA LEU ILE ALA ALA ALA VAL SER GLU
SEQRES  10 J  194  LEU SER GLY ALA VAL LYS GLU GLN VAL LYS GLY VAL ALA
SEQRES  11 J  194  LEU PHE GLY TYR THR GLN ASN LEU GLN ASN ARG GLY GLY
SEQRES  12 J  194  ILE PRO ASN TYR PRO ARG GLU ARG THR LYS VAL PHE CYS
SEQRES  13 J  194  ASN VAL GLY ASP ALA VAL CYS THR GLY THR LEU ILE ILE
SEQRES  14 J  194  THR PRO ALA HIS LEU SER TYR THR ILE GLU ALA ARG GLY
SEQRES  15 J  194  GLU ALA ALA ARG PHE LEU ARG ASP ARG ILE ARG ALA
SEQRES   1 K  194  GLN LEU GLY ALA ILE GLU ASN GLY LEU GLU SER GLY SER
SEQRES   2 K  194  ALA ASN ALA CYS PRO ASP ALA ILE LEU ILE PHE ALA ARG
SEQRES   3 K  194  GLY SER THR GLU PRO GLY ASN MET GLY ILE THR VAL GLY
SEQRES   4 K  194  PRO ALA LEU ALA ASN GLY LEU GLU SER HIS ILE ARG ASN
SEQRES   5 K  194  ILE TRP ILE GLN GLY VAL GLY GLY PRO TYR ASP ALA ALA
SEQRES   6 K  194  LEU ALA THR ASN PHE LEU PRO ARG GLY THR SER GLN ALA
SEQRES   7 K  194  ASN ILE ASP GLU GLY LYS ARG LEU PHE ALA LEU ALA ASN
SEQRES   8 K  194  GLN LYS CYS PRO ASN THR PRO VAL VAL ALA GLY GLY TYR
SEQRES   9 K  194  SER GLN GLY ALA ALA LEU ILE ALA ALA ALA VAL SER GLU
SEQRES  10 K  194  LEU SER GLY ALA VAL LYS GLU GLN VAL LYS GLY VAL ALA
SEQRES  11 K  194  LEU PHE GLY TYR THR GLN ASN LEU GLN ASN ARG GLY GLY
SEQRES  12 K  194  ILE PRO ASN TYR PRO ARG GLU ARG THR LYS VAL PHE CYS
SEQRES  13 K  194  ASN VAL GLY ASP ALA VAL CYS THR GLY THR LEU ILE ILE
SEQRES  14 K  194  THR PRO ALA HIS LEU SER TYR THR ILE GLU ALA ARG GLY
SEQRES  15 K  194  GLU ALA ALA ARG PHE LEU ARG ASP ARG ILE ARG ALA
SEQRES   1 L  194  GLN LEU GLY ALA ILE GLU ASN GLY LEU GLU SER GLY SER
SEQRES   2 L  194  ALA ASN ALA CYS PRO ASP ALA ILE LEU ILE PHE ALA ARG
SEQRES   3 L  194  GLY SER THR GLU PRO GLY ASN MET GLY ILE THR VAL GLY
SEQRES   4 L  194  PRO ALA LEU ALA ASN GLY LEU GLU SER HIS ILE ARG ASN
SEQRES   5 L  194  ILE TRP ILE GLN GLY VAL GLY GLY PRO TYR ASP ALA ALA
SEQRES   6 L  194  LEU ALA THR ASN PHE LEU PRO ARG GLY THR SER GLN ALA
SEQRES   7 L  194  ASN ILE ASP GLU GLY LYS ARG LEU PHE ALA LEU ALA ASN
SEQRES   8 L  194  GLN LYS CYS PRO ASN THR PRO VAL VAL ALA GLY GLY TYR
SEQRES   9 L  194  SER GLN GLY ALA ALA LEU ILE ALA ALA ALA VAL SER GLU
SEQRES  10 L  194  LEU SER GLY ALA VAL LYS GLU GLN VAL LYS GLY VAL ALA
SEQRES  11 L  194  LEU PHE GLY TYR THR GLN ASN LEU GLN ASN ARG GLY GLY
SEQRES  12 L  194  ILE PRO ASN TYR PRO ARG GLU ARG THR LYS VAL PHE CYS
SEQRES  13 L  194  ASN VAL GLY ASP ALA VAL CYS THR GLY THR LEU ILE ILE
SEQRES  14 L  194  THR PRO ALA HIS LEU SER TYR THR ILE GLU ALA ARG GLY
SEQRES  15 L  194  GLU ALA ALA ARG PHE LEU ARG ASP ARG ILE ARG ALA
FORMUL  13  HOH   *98(H2 O)
HELIX    1 AA1 ASN A    7  GLY A   12  1                                   6
HELIX    2 AA2 SER A   13  CYS A   17  5                                   5
HELIX    3 AA3 THR A   37  SER A   48  1                                  12
HELIX    4 AA4 LEU A   66  LEU A   71  5                                   6
HELIX    5 AA5 SER A   76  CYS A   94  1                                  19
HELIX    6 AA6 SER A  105  GLU A  117  1                                  13
HELIX    7 AA7 SER A  119  GLN A  125  1                                   7
HELIX    8 AA8 PRO A  148  GLU A  150  5                                   3
HELIX    9 AA9 ASP A  160  GLY A  165  5                                   6
HELIX   10 AB1 THR A  170  SER A  175  5                                   6
HELIX   11 AB2 TYR A  176  GLY A  182  1                                   7
HELIX   12 AB3 GLY A  182  ARG A  193  1                                  12
HELIX   13 AB4 ASN B    7  GLY B   12  1                                   6
HELIX   14 AB5 SER B   13  CYS B   17  5                                   5
HELIX   15 AB6 THR B   37  SER B   48  1                                  12
HELIX   16 AB7 LEU B   66  LEU B   71  5                                   6
HELIX   17 AB8 SER B   76  CYS B   94  1                                  19
HELIX   18 AB9 SER B  105  GLU B  117  1                                  13
HELIX   19 AC1 SER B  119  GLN B  125  1                                   7
HELIX   20 AC2 PRO B  148  GLU B  150  5                                   3
HELIX   21 AC3 ASP B  160  GLY B  165  5                                   6
HELIX   22 AC4 THR B  170  SER B  175  5                                   6
HELIX   23 AC5 TYR B  176  GLY B  182  1                                   7
HELIX   24 AC6 GLY B  182  ARG B  193  1                                  12
HELIX   25 AC7 ASN C    7  GLY C   12  1                                   6
HELIX   26 AC8 THR C   37  SER C   48  1                                  12
HELIX   27 AC9 LEU C   66  LEU C   71  5                                   6
HELIX   28 AD1 SER C   76  CYS C   94  1                                  19
HELIX   29 AD2 SER C  105  GLU C  117  1                                  13
HELIX   30 AD3 SER C  119  GLN C  125  1                                   7
HELIX   31 AD4 PRO C  148  GLU C  150  5                                   3
HELIX   32 AD5 ASP C  160  GLY C  165  5                                   6
HELIX   33 AD6 THR C  170  SER C  175  5                                   6
HELIX   34 AD7 TYR C  176  GLY C  182  1                                   7
HELIX   35 AD8 GLY C  182  ILE C  192  1                                  11
HELIX   36 AD9 ASN D    7  GLY D   12  1                                   6
HELIX   37 AE1 SER D   13  CYS D   17  5                                   5
HELIX   38 AE2 THR D   37  SER D   48  1                                  12
HELIX   39 AE3 LEU D   66  LEU D   71  5                                   6
HELIX   40 AE4 SER D   76  CYS D   94  1                                  19
HELIX   41 AE5 SER D  105  GLU D  117  1                                  13
HELIX   42 AE6 SER D  119  GLN D  125  1                                   7
HELIX   43 AE7 PRO D  148  GLU D  150  5                                   3
HELIX   44 AE8 ASP D  160  GLY D  165  5                                   6
HELIX   45 AE9 THR D  170  SER D  175  5                                   6
HELIX   46 AF1 TYR D  176  GLY D  182  1                                   7
HELIX   47 AF2 GLY D  182  ARG D  193  1                                  12
HELIX   48 AF3 ASN E    7  GLY E   12  1                                   6
HELIX   49 AF4 SER E   13  CYS E   17  5                                   5
HELIX   50 AF5 THR E   37  SER E   48  1                                  12
HELIX   51 AF6 LEU E   66  LEU E   71  5                                   6
HELIX   52 AF7 SER E   76  CYS E   94  1                                  19
HELIX   53 AF8 SER E  105  GLU E  117  1                                  13
HELIX   54 AF9 SER E  119  GLN E  125  1                                   7
HELIX   55 AG1 PRO E  148  GLU E  150  5                                   3
HELIX   56 AG2 ASP E  160  GLY E  165  5                                   6
HELIX   57 AG3 THR E  170  SER E  175  5                                   6
HELIX   58 AG4 TYR E  176  GLY E  182  1                                   7
HELIX   59 AG5 GLY E  182  ARG E  193  1                                  12
HELIX   60 AG6 ASN F    7  GLY F   12  1                                   6
HELIX   61 AG7 THR F   37  SER F   48  1                                  12
HELIX   62 AG8 LEU F   66  LEU F   71  5                                   6
HELIX   63 AG9 SER F   76  CYS F   94  1                                  19
HELIX   64 AH1 SER F  105  GLU F  117  1                                  13
HELIX   65 AH2 SER F  119  GLN F  125  1                                   7
HELIX   66 AH3 PRO F  148  GLU F  150  5                                   3
HELIX   67 AH4 ASP F  160  GLY F  165  5                                   6
HELIX   68 AH5 THR F  170  SER F  175  5                                   6
HELIX   69 AH6 TYR F  176  GLY F  182  1                                   7
HELIX   70 AH7 GLY F  182  ILE F  192  1                                  11
HELIX   71 AH8 ASN G    7  GLY G   12  1                                   6
HELIX   72 AH9 THR G   37  SER G   48  1                                  12
HELIX   73 AI1 LEU G   66  LEU G   71  5                                   6
HELIX   74 AI2 SER G   76  CYS G   94  1                                  19
HELIX   75 AI3 SER G  105  GLU G  117  1                                  13
HELIX   76 AI4 SER G  119  GLN G  125  1                                   7
HELIX   77 AI5 PRO G  148  GLU G  150  5                                   3
HELIX   78 AI6 ASP G  160  GLY G  165  5                                   6
HELIX   79 AI7 THR G  170  SER G  175  5                                   6
HELIX   80 AI8 TYR G  176  GLY G  182  1                                   7
HELIX   81 AI9 GLY G  182  ARG G  193  1                                  12
HELIX   82 AJ1 ASN H    7  GLY H   12  1                                   6
HELIX   83 AJ2 SER H   13  CYS H   17  5                                   5
HELIX   84 AJ3 THR H   37  SER H   48  1                                  12
HELIX   85 AJ4 LEU H   66  LEU H   71  5                                   6
HELIX   86 AJ5 SER H   76  CYS H   94  1                                  19
HELIX   87 AJ6 SER H  105  GLU H  117  1                                  13
HELIX   88 AJ7 SER H  119  GLN H  125  1                                   7
HELIX   89 AJ8 PRO H  148  GLU H  150  5                                   3
HELIX   90 AJ9 ASP H  160  GLY H  165  5                                   6
HELIX   91 AK1 THR H  170  SER H  175  5                                   6
HELIX   92 AK2 TYR H  176  GLY H  182  1                                   7
HELIX   93 AK3 GLY H  182  ARG H  193  1                                  12
HELIX   94 AK4 ASN I    7  GLY I   12  1                                   6
HELIX   95 AK5 SER I   13  CYS I   17  5                                   5
HELIX   96 AK6 THR I   37  SER I   48  1                                  12
HELIX   97 AK7 LEU I   66  LEU I   71  5                                   6
HELIX   98 AK8 SER I   76  CYS I   94  1                                  19
HELIX   99 AK9 SER I  105  GLU I  117  1                                  13
HELIX  100 AL1 SER I  119  GLN I  125  1                                   7
HELIX  101 AL2 PRO I  148  GLU I  150  5                                   3
HELIX  102 AL3 ASP I  160  GLY I  165  5                                   6
HELIX  103 AL4 THR I  170  SER I  175  5                                   6
HELIX  104 AL5 TYR I  176  GLY I  182  1                                   7
HELIX  105 AL6 GLY I  182  ILE I  192  1                                  11
HELIX  106 AL7 ASN J    7  GLY J   12  1                                   6
HELIX  107 AL8 THR J   37  SER J   48  1                                  12
HELIX  108 AL9 LEU J   66  LEU J   71  5                                   6
HELIX  109 AM1 SER J   76  CYS J   94  1                                  19
HELIX  110 AM2 SER J  105  GLU J  117  1                                  13
HELIX  111 AM3 SER J  119  GLN J  125  1                                   7
HELIX  112 AM4 PRO J  148  GLU J  150  5                                   3
HELIX  113 AM5 ASP J  160  GLY J  165  5                                   6
HELIX  114 AM6 THR J  170  SER J  175  5                                   6
HELIX  115 AM7 TYR J  176  GLY J  182  1                                   7
HELIX  116 AM8 GLY J  182  ARG J  193  1                                  12
HELIX  117 AM9 ASN K    7  GLY K   12  1                                   6
HELIX  118 AN1 SER K   13  CYS K   17  5                                   5
HELIX  119 AN2 THR K   37  SER K   48  1                                  12
HELIX  120 AN3 LEU K   66  LEU K   71  5                                   6
HELIX  121 AN4 SER K   76  CYS K   94  1                                  19
HELIX  122 AN5 SER K  105  GLU K  117  1                                  13
HELIX  123 AN6 SER K  119  GLN K  125  1                                   7
HELIX  124 AN7 PRO K  148  GLU K  150  5                                   3
HELIX  125 AN8 ASP K  160  GLY K  165  5                                   6
HELIX  126 AN9 THR K  170  SER K  175  5                                   6
HELIX  127 AO1 TYR K  176  GLY K  182  1                                   7
HELIX  128 AO2 GLY K  182  ARG K  193  1                                  12
HELIX  129 AO3 ASN L    7  GLY L   12  1                                   6
HELIX  130 AO4 SER L   13  CYS L   17  5                                   5
HELIX  131 AO5 THR L   37  SER L   48  1                                  12
HELIX  132 AO6 LEU L   66  LEU L   71  5                                   6
HELIX  133 AO7 SER L   76  CYS L   94  1                                  19
HELIX  134 AO8 SER L  105  GLU L  117  1                                  13
HELIX  135 AO9 SER L  119  GLN L  125  1                                   7
HELIX  136 AP1 PRO L  148  GLU L  150  5                                   3
HELIX  137 AP2 ASP L  160  GLY L  165  5                                   6
HELIX  138 AP3 THR L  170  SER L  175  5                                   6
HELIX  139 AP4 TYR L  176  GLY L  182  1                                   7
HELIX  140 AP5 GLY L  182  ILE L  192  1                                  11
SHEET    1 AA1 5 ILE A  53  GLY A  57  0
SHEET    2 AA1 5 ALA A  20  ALA A  25  1  N  LEU A  22   O  TRP A  54
SHEET    3 AA1 5 VAL A  99  TYR A 104  1  O  VAL A 100   N  ILE A  21
SHEET    4 AA1 5 VAL A 126  PHE A 132  1  O  ALA A 130   N  ALA A 101
SHEET    5 AA1 5 THR A 152  PHE A 155  1  O  PHE A 155   N  LEU A 131
SHEET    1 AA2 5 ILE B  53  GLY B  57  0
SHEET    2 AA2 5 ALA B  20  ALA B  25  1  N  LEU B  22   O  TRP B  54
SHEET    3 AA2 5 VAL B  99  TYR B 104  1  O  VAL B 100   N  ILE B  21
SHEET    4 AA2 5 VAL B 126  PHE B 132  1  O  ALA B 130   N  ALA B 101
SHEET    5 AA2 5 THR B 152  PHE B 155  1  O  PHE B 155   N  LEU B 131
SHEET    1 AA3 5 ILE C  53  GLY C  57  0
SHEET    2 AA3 5 ALA C  20  ALA C  25  1  N  LEU C  22   O  TRP C  54
SHEET    3 AA3 5 VAL C  99  TYR C 104  1  O  VAL C 100   N  ILE C  21
SHEET    4 AA3 5 VAL C 126  PHE C 132  1  O  ALA C 130   N  ALA C 101
SHEET    5 AA3 5 THR C 152  PHE C 155  1  O  PHE C 155   N  LEU C 131
SHEET    1 AA4 5 ILE D  53  GLY D  57  0
SHEET    2 AA4 5 ALA D  20  ALA D  25  1  N  LEU D  22   O  TRP D  54
SHEET    3 AA4 5 VAL D  99  TYR D 104  1  O  VAL D 100   N  ILE D  21
SHEET    4 AA4 5 VAL D 126  PHE D 132  1  O  ALA D 130   N  ALA D 101
SHEET    5 AA4 5 THR D 152  PHE D 155  1  O  PHE D 155   N  LEU D 131
SHEET    1 AA5 5 ILE E  53  GLY E  57  0
SHEET    2 AA5 5 ALA E  20  ALA E  25  1  N  LEU E  22   O  TRP E  54
SHEET    3 AA5 5 VAL E  99  TYR E 104  1  O  VAL E 100   N  ILE E  21
SHEET    4 AA5 5 VAL E 126  PHE E 132  1  O  ALA E 130   N  ALA E 101
SHEET    5 AA5 5 THR E 152  PHE E 155  1  O  PHE E 155   N  LEU E 131
SHEET    1 AA6 5 ILE F  53  GLY F  57  0
SHEET    2 AA6 5 ALA F  20  ALA F  25  1  N  LEU F  22   O  TRP F  54
SHEET    3 AA6 5 VAL F  99  TYR F 104  1  O  VAL F 100   N  ILE F  21
SHEET    4 AA6 5 VAL F 126  PHE F 132  1  O  ALA F 130   N  ALA F 101
SHEET    5 AA6 5 THR F 152  PHE F 155  1  O  PHE F 155   N  LEU F 131
SHEET    1 AA7 5 ILE G  53  GLY G  57  0
SHEET    2 AA7 5 ALA G  20  ALA G  25  1  N  LEU G  22   O  TRP G  54
SHEET    3 AA7 5 VAL G  99  TYR G 104  1  O  VAL G 100   N  ILE G  21
SHEET    4 AA7 5 VAL G 126  PHE G 132  1  O  ALA G 130   N  ALA G 101
SHEET    5 AA7 5 THR G 152  PHE G 155  1  O  PHE G 155   N  LEU G 131
SHEET    1 AA8 5 ILE H  53  GLY H  57  0
SHEET    2 AA8 5 ALA H  20  ALA H  25  1  N  PHE H  24   O  GLN H  56
SHEET    3 AA8 5 VAL H  99  TYR H 104  1  O  VAL H 100   N  ILE H  21
SHEET    4 AA8 5 VAL H 126  PHE H 132  1  O  ALA H 130   N  ALA H 101
SHEET    5 AA8 5 THR H 152  PHE H 155  1  O  PHE H 155   N  LEU H 131
SHEET    1 AA9 5 ILE I  53  GLY I  57  0
SHEET    2 AA9 5 ALA I  20  ALA I  25  1  N  LEU I  22   O  TRP I  54
SHEET    3 AA9 5 VAL I  99  TYR I 104  1  O  VAL I 100   N  ILE I  21
SHEET    4 AA9 5 VAL I 126  PHE I 132  1  O  ALA I 130   N  ALA I 101
SHEET    5 AA9 5 THR I 152  PHE I 155  1  O  PHE I 155   N  LEU I 131
SHEET    1 AB1 5 ILE J  53  GLY J  57  0
SHEET    2 AB1 5 ALA J  20  ALA J  25  1  N  LEU J  22   O  TRP J  54
SHEET    3 AB1 5 VAL J  99  TYR J 104  1  O  VAL J 100   N  ILE J  21
SHEET    4 AB1 5 VAL J 126  PHE J 132  1  O  ALA J 130   N  ALA J 101
SHEET    5 AB1 5 THR J 152  PHE J 155  1  O  PHE J 155   N  LEU J 131
SHEET    1 AB2 5 ILE K  53  GLY K  57  0
SHEET    2 AB2 5 ALA K  20  ALA K  25  1  N  LEU K  22   O  TRP K  54
SHEET    3 AB2 5 VAL K  99  TYR K 104  1  O  VAL K 100   N  ILE K  21
SHEET    4 AB2 5 VAL K 126  PHE K 132  1  O  ALA K 130   N  ALA K 101
SHEET    5 AB2 5 THR K 152  PHE K 155  1  O  PHE K 155   N  LEU K 131
SHEET    1 AB3 5 ILE L  53  GLY L  57  0
SHEET    2 AB3 5 ALA L  20  ALA L  25  1  N  LEU L  22   O  TRP L  54
SHEET    3 AB3 5 VAL L  99  TYR L 104  1  O  VAL L 100   N  ILE L  21
SHEET    4 AB3 5 VAL L 126  PHE L 132  1  O  ALA L 130   N  ALA L 101
SHEET    5 AB3 5 THR L 152  PHE L 155  1  O  PHE L 155   N  LEU L 131
SSBOND   1 CYS A   17    CYS A   94                          1555   1555  2.04
SSBOND   2 CYS A  156    CYS A  163                          1555   1555  2.03
SSBOND   3 CYS B   17    CYS B   94                          1555   1555  2.02
SSBOND   4 CYS B  156    CYS B  163                          1555   1555  2.02
SSBOND   5 CYS C   17    CYS C   94                          1555   1555  2.02
SSBOND   6 CYS C  156    CYS C  163                          1555   1555  1.99
SSBOND   7 CYS D   17    CYS D   94                          1555   1555  2.02
SSBOND   8 CYS D  156    CYS D  163                          1555   1555  2.03
SSBOND   9 CYS E   17    CYS E   94                          1555   1555  2.03
SSBOND  10 CYS E  156    CYS E  163                          1555   1555  2.01
SSBOND  11 CYS F   17    CYS F   94                          1555   1555  2.01
SSBOND  12 CYS F  156    CYS F  163                          1555   1555  2.00
SSBOND  13 CYS G   17    CYS G   94                          1555   1555  2.02
SSBOND  14 CYS G  156    CYS G  163                          1555   1555  2.02
SSBOND  15 CYS H   17    CYS H   94                          1555   1555  2.02
SSBOND  16 CYS H  156    CYS H  163                          1555   1555  2.01
SSBOND  17 CYS I   17    CYS I   94                          1555   1555  2.03
SSBOND  18 CYS I  156    CYS I  163                          1555   1555  2.00
SSBOND  19 CYS J   17    CYS J   94                          1555   1555  2.02
SSBOND  20 CYS J  156    CYS J  163                          1555   1555  2.01
SSBOND  21 CYS K   17    CYS K   94                          1555   1555  2.02
SSBOND  22 CYS K  156    CYS K  163                          1555   1555  2.00
SSBOND  23 CYS L   17    CYS L   94                          1555   1555  2.02
SSBOND  24 CYS L  156    CYS L  163                          1555   1555  2.01
CISPEP   1 GLY A    3    ALA A    4          0         1.47
CISPEP   2 GLY B    3    ALA B    4          0         2.80
CISPEP   3 GLY D    3    ALA D    4          0         1.54
CISPEP   4 GLY E    3    ALA E    4          0        12.96
CISPEP   5 GLY H    3    ALA H    4          0         1.99
CISPEP   6 GLY J    3    ALA J    4          0         1.64
CISPEP   7 GLY K    3    ALA K    4          0         2.62
CRYST1  125.548  126.999  134.505  90.00  90.00  90.00 P 21 21 21   48
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.007965  0.000000  0.000000        0.00000
SCALE2      0.000000  0.007874  0.000000        0.00000
SCALE3      0.000000  0.000000  0.007435        0.00000
TER    1403      ARG A 193
TER    2801      ARG B 193
TER    4221      ARG C 193
TER    5624      ARG D 193
TER    7021      ARG E 193
TER    8441      ARG F 193
TER    9858      ARG G 193
TER   11261      ARG H 193
TER   12672      ARG I 193
TER   14075      ARG J 193
TER   15478      ARG K 193
TER   16889      ARG L 193
MASTER      536    0    0  140   60    0    0    616975   12   48  180
END