longtext: 4P93-pdb

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HEADER    HYDROLASE                               02-APR-14   4P93
TITLE     STRUCTURE OF DIENELACTONE HYDROLASE AT 1.85 A RESOLUTION CRYSTALLISED
TITLE    2 IN THE C2 SPACE GROUP
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: CARBOXYMETHYLENEBUTENOLIDASE;
COMPND   3 CHAIN: A, B;
COMPND   4 SYNONYM: DIENELACTONE HYDROLASE,DLH;
COMPND   5 EC: 3.1.1.45;
COMPND   6 ENGINEERED: YES;
COMPND   7 MUTATION: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: PSEUDOMONAS SP.;
SOURCE   3 ORGANISM_TAXID: 65741;
SOURCE   4 STRAIN: B13;
SOURCE   5 GENE: CLCD;
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    HYDROLASE, A/B HYDROLASE FOLD
EXPDTA    X-RAY DIFFRACTION
AUTHOR    J.L.PORTER,P.D.CARR,C.A.COLLYER,D.L.OLLIS
REVDAT   1   09-JUL-14 4P93    0
JRNL        AUTH   J.L.PORTER,P.D.CARR,C.A.COLLYER,D.L.OLLIS
JRNL        TITL   CRYSTALLIZATION OF DIENELACTONE HYDROLASE IN TWO SPACE
JRNL        TITL 2 GROUPS: STRUCTURAL CHANGES CAUSED BY CRYSTAL PACKING
JRNL        REF    ACTA CRYSTALLOGR.,SECT.F      V.  70   884 2014
JRNL        REFN                   ESSN 1744-3091
JRNL        DOI    10.1107/S2053230X1401108X
REMARK   2
REMARK   2 RESOLUTION.    1.85 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.6.0117
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.85
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 89.36
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL
REMARK   3   COMPLETENESS FOR RANGE        (%) : 94.0
REMARK   3   NUMBER OF REFLECTIONS             : 33459
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.175
REMARK   3   R VALUE            (WORKING SET) : 0.173
REMARK   3   FREE R VALUE                     : 0.205
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000
REMARK   3   FREE R VALUE TEST SET COUNT      : 1770
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 1.85
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 1.90
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 2299
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 88.76
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2010
REMARK   3   BIN FREE R VALUE SET COUNT          : 117
REMARK   3   BIN FREE R VALUE                    : 0.2630
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 3542
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 0
REMARK   3   SOLVENT ATOMS            : 184
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 21.07
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -0.31000
REMARK   3    B22 (A**2) : 0.98000
REMARK   3    B33 (A**2) : -0.62000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.31000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.149
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.132
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.083
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 2.688
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.953
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.932
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  3649 ; 0.008 ; 0.019
REMARK   3   BOND LENGTHS OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES):  4969 ; 1.087 ; 1.947
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):   468 ; 6.733 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   169 ;34.138 ;23.905
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):   533 ;14.847 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    20 ;21.347 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):   528 ; 0.098 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  2881 ; 0.021 ; 0.021
REMARK   3   GENERAL PLANES OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2):  NULL ;  NULL ;  NULL
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NCS TYPE: LOCAL
REMARK   3   NUMBER OF DIFFERENT NCS PAIRS  : 1
REMARK   3  GROUP  CHAIN1    RANGE     CHAIN2     RANGE    COUNT RMS  WEIGHT
REMARK   3    1     A     1    233       B     1    233     265  0.16  0.05
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : BABINET MODEL WITH MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN USED IF PRESENT IN
REMARK   3  THE INPUT
REMARK   4
REMARK   4 4P93 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 03-APR-14.
REMARK 100 THE DEPOSITION ID IS D_1000200957.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 15-OCT-12
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 5.8
REMARK 200  NUMBER OF CRYSTALS USED        : NULL
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : N
REMARK 200  RADIATION SOURCE               : SEALED TUBE
REMARK 200  BEAMLINE                       : NULL
REMARK 200  X-RAY GENERATOR MODEL          : OTHER
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.5418
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : IMAGE PLATE
REMARK 200  DETECTOR MANUFACTURER          : MAR SCANNER 345 MM PLATE
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : NULL
REMARK 200  DATA SCALING SOFTWARE          : NULL
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 35229
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.850
REMARK 200  RESOLUTION RANGE LOW       (A) : 89.360
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 94.0
REMARK 200  DATA REDUNDANCY                : 3.200
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 16.8900
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.85
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.90
REMARK 200  COMPLETENESS FOR SHELL     (%) : 88.9
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 5.100
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: NULL
REMARK 200 STARTING MODEL: 1ZI6
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 42.89
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.15
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: SODIUM CITRATE
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 1 2 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y,-Z
REMARK 290       3555   X+1/2,Y+1/2,Z
REMARK 290       4555   -X+1/2,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   3  1.000000  0.000000  0.000000       50.11500
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       24.52500
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000       50.11500
REMARK 290   SMTRY2   4  0.000000  1.000000  0.000000       24.52500
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 860 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 19240 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: 0.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     LYS A   234
REMARK 465     LYS A   235
REMARK 465     PRO A   236
REMARK 465     LYS B   234
REMARK 465     LYS B   235
REMARK 465     PRO B   236
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     PHE A 173    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     LYS B  25    CG   CD   CE   NZ
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   NH2  ARG A    79     O    HOH A   301              1.79
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ASN A  41     -163.79   -104.16
REMARK 500    ALA A  68       72.49   -173.68
REMARK 500    SER A 123     -111.32     61.59
REMARK 500    TYR A 145       54.32     33.32
REMARK 500    GLU B  36     -157.81    -75.85
REMARK 500    ASN B  41     -160.98   -109.26
REMARK 500    ALA B  68       85.22   -168.94
REMARK 500    SER B 123     -117.41     61.66
REMARK 500    TYR B 145       56.13     30.78
REMARK 500
REMARK 500 REMARK: NULL
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 4P92   RELATED DB: PDB
REMARK 900 4P92 IS THE SAME PROTEIN BUT CRYSTALLISED IN A DIFFERENT SPACE GROUP
DBREF  4P93 A    1   236  UNP    P0A115   CLCD_PSESB       1    236
DBREF  4P93 B    1   236  UNP    P0A115   CLCD_PSESB       1    236
SEQADV 4P93 SER A  123  UNP  P0A115    CYS   123 ENGINEERED MUTATION
SEQADV 4P93 ASN A  154  UNP  P0A115    LYS   154 CONFLICT
SEQADV 4P93 THR A  224  UNP  P0A115    ARG   224 CONFLICT
SEQADV 4P93 SER B  123  UNP  P0A115    CYS   123 ENGINEERED MUTATION
SEQADV 4P93 ASN B  154  UNP  P0A115    LYS   154 CONFLICT
SEQADV 4P93 THR B  224  UNP  P0A115    ARG   224 CONFLICT
SEQRES   1 A  236  MET LEU THR GLU GLY ILE SER ILE GLN SER TYR ASP GLY
SEQRES   2 A  236  HIS THR PHE GLY ALA LEU VAL GLY SER PRO ALA LYS ALA
SEQRES   3 A  236  PRO ALA PRO VAL ILE VAL ILE ALA GLN GLU ILE PHE GLY
SEQRES   4 A  236  VAL ASN ALA PHE MET ARG GLU THR VAL SER TRP LEU VAL
SEQRES   5 A  236  ASP GLN GLY TYR ALA ALA VAL CYS PRO ASP LEU TYR ALA
SEQRES   6 A  236  ARG GLN ALA PRO GLY THR ALA LEU ASP PRO GLN ASP GLU
SEQRES   7 A  236  ARG GLN ARG GLU GLN ALA TYR LYS LEU TRP GLN ALA PHE
SEQRES   8 A  236  ASP MET GLU ALA GLY VAL GLY ASP LEU GLU ALA ALA ILE
SEQRES   9 A  236  ARG TYR ALA ARG HIS GLN PRO TYR SER ASN GLY LYS VAL
SEQRES  10 A  236  GLY LEU VAL GLY TYR SER LEU GLY GLY ALA LEU ALA PHE
SEQRES  11 A  236  LEU VAL ALA ALA LYS GLY TYR VAL ASP ARG ALA VAL GLY
SEQRES  12 A  236  TYR TYR GLY VAL GLY LEU GLU LYS GLN LEU ASN LYS VAL
SEQRES  13 A  236  PRO GLU VAL LYS HIS PRO ALA LEU PHE HIS MET GLY GLY
SEQRES  14 A  236  GLN ASP HIS PHE VAL PRO ALA PRO SER ARG GLN LEU ILE
SEQRES  15 A  236  THR GLU GLY PHE GLY ALA ASN PRO LEU LEU GLN VAL HIS
SEQRES  16 A  236  TRP TYR GLU GLU ALA GLY HIS SER PHE ALA ARG THR SER
SEQRES  17 A  236  SER SER GLY TYR VAL ALA SER ALA ALA ALA LEU ALA ASN
SEQRES  18 A  236  GLU ARG THR LEU ASP PHE LEU ALA PRO LEU GLN SER LYS
SEQRES  19 A  236  LYS PRO
SEQRES   1 B  236  MET LEU THR GLU GLY ILE SER ILE GLN SER TYR ASP GLY
SEQRES   2 B  236  HIS THR PHE GLY ALA LEU VAL GLY SER PRO ALA LYS ALA
SEQRES   3 B  236  PRO ALA PRO VAL ILE VAL ILE ALA GLN GLU ILE PHE GLY
SEQRES   4 B  236  VAL ASN ALA PHE MET ARG GLU THR VAL SER TRP LEU VAL
SEQRES   5 B  236  ASP GLN GLY TYR ALA ALA VAL CYS PRO ASP LEU TYR ALA
SEQRES   6 B  236  ARG GLN ALA PRO GLY THR ALA LEU ASP PRO GLN ASP GLU
SEQRES   7 B  236  ARG GLN ARG GLU GLN ALA TYR LYS LEU TRP GLN ALA PHE
SEQRES   8 B  236  ASP MET GLU ALA GLY VAL GLY ASP LEU GLU ALA ALA ILE
SEQRES   9 B  236  ARG TYR ALA ARG HIS GLN PRO TYR SER ASN GLY LYS VAL
SEQRES  10 B  236  GLY LEU VAL GLY TYR SER LEU GLY GLY ALA LEU ALA PHE
SEQRES  11 B  236  LEU VAL ALA ALA LYS GLY TYR VAL ASP ARG ALA VAL GLY
SEQRES  12 B  236  TYR TYR GLY VAL GLY LEU GLU LYS GLN LEU ASN LYS VAL
SEQRES  13 B  236  PRO GLU VAL LYS HIS PRO ALA LEU PHE HIS MET GLY GLY
SEQRES  14 B  236  GLN ASP HIS PHE VAL PRO ALA PRO SER ARG GLN LEU ILE
SEQRES  15 B  236  THR GLU GLY PHE GLY ALA ASN PRO LEU LEU GLN VAL HIS
SEQRES  16 B  236  TRP TYR GLU GLU ALA GLY HIS SER PHE ALA ARG THR SER
SEQRES  17 B  236  SER SER GLY TYR VAL ALA SER ALA ALA ALA LEU ALA ASN
SEQRES  18 B  236  GLU ARG THR LEU ASP PHE LEU ALA PRO LEU GLN SER LYS
SEQRES  19 B  236  LYS PRO
FORMUL   3  HOH   *184(H2 O)
HELIX    1 AA1 ASN A   41  GLN A   54  1                                  14
HELIX    2 AA2 ASP A   77  PHE A   91  1                                  15
HELIX    3 AA3 ASP A   92  HIS A  109  1                                  18
HELIX    4 AA4 SER A  123  GLY A  136  1                                  14
HELIX    5 AA5 GLY A  148  VAL A  159  5                                  12
HELIX    6 AA6 PRO A  177  GLY A  187  1                                  11
HELIX    7 AA7 VAL A  213  ALA A  229  1                                  17
HELIX    8 AA8 PRO A  230  GLN A  232  5                                   3
HELIX    9 AA9 ASN B   41  GLN B   54  1                                  14
HELIX   10 AB1 LEU B   63  GLN B   67  5                                   5
HELIX   11 AB2 ASP B   77  ALA B   90  1                                  14
HELIX   12 AB3 ASP B   92  ARG B  108  1                                  17
HELIX   13 AB4 SER B  123  GLY B  136  1                                  14
HELIX   14 AB5 GLY B  148  VAL B  159  5                                  12
HELIX   15 AB6 PRO B  175  GLY B  187  1                                  13
HELIX   16 AB7 VAL B  213  ALA B  229  1                                  17
HELIX   17 AB8 PRO B  230  GLN B  232  5                                   3
SHEET    1 AA1 2 ILE A   8  GLN A   9  0
SHEET    2 AA1 2 THR A  15  PHE A  16 -1  O  PHE A  16   N  ILE A   8
SHEET    1 AA2 7 ALA A  18  GLY A  21  0
SHEET    2 AA2 7 ALA A  57  PRO A  61 -1  O  CYS A  60   N  LEU A  19
SHEET    3 AA2 7 ALA A  28  ALA A  34  1  N  ILE A  31   O  ALA A  57
SHEET    4 AA2 7 SER A 113  TYR A 122  1  O  GLY A 118   N  VAL A  32
SHEET    5 AA2 7 ARG A 140  TYR A 144  1  O  TYR A 144   N  GLY A 121
SHEET    6 AA2 7 ALA A 163  GLY A 168  1  O  LEU A 164   N  ALA A 141
SHEET    7 AA2 7 LEU A 192  TYR A 197  1  O  HIS A 195   N  MET A 167
SHEET    1 AA3 2 ILE B   8  GLN B   9  0
SHEET    2 AA3 2 THR B  15  PHE B  16 -1  O  PHE B  16   N  ILE B   8
SHEET    1 AA4 7 ALA B  18  GLY B  21  0
SHEET    2 AA4 7 ALA B  57  PRO B  61 -1  O  CYS B  60   N  LEU B  19
SHEET    3 AA4 7 ALA B  28  ALA B  34  1  N  ILE B  31   O  ALA B  57
SHEET    4 AA4 7 SER B 113  TYR B 122  1  O  GLY B 118   N  VAL B  32
SHEET    5 AA4 7 ARG B 140  TYR B 144  1  O  TYR B 144   N  GLY B 121
SHEET    6 AA4 7 ALA B 163  GLY B 168  1  O  LEU B 164   N  ALA B 141
SHEET    7 AA4 7 LEU B 192  TYR B 197  1  O  HIS B 195   N  MET B 167
CISPEP   1 ALA A   26    PRO A   27          0         1.10
CISPEP   2 ALA B   26    PRO B   27          0        -8.01
CRYST1  100.230   49.050   89.610  90.00  94.30  90.00 C 1 2 1       8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.009977  0.000000  0.000749        0.00000
SCALE2      0.000000  0.020387  0.000000        0.00000
SCALE3      0.000000  0.000000  0.011191        0.00000
TER    1783      SER A 233
TER    3556      SER B 233
MASTER      300    0    0   17   18    0    0    6 3726    2    0   38
END