longtext: 4QNN-pdb

content
HEADER    HYDROLASE                               18-JUN-14   4QNN
TITLE     CRYSTAL STRUCTURE OF PHOSPHOLIPASE A 1 FROM HORNET(VESPA BASALIS)
TITLE    2 VENOM
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: PHOSPHOLIPASE A 1  FROM HORNET(VESPA BASALIS) VENOM;
COMPND   3 CHAIN: A, B, C, D;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: VESPA BASALIS;
SOURCE   3 ORGANISM_TAXID: 7444;
SOURCE   4 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   5 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    ALPHA / BATA HYDROLASE FAMILY FOLD, PHOSPHOLIPASE A1, PHOSPHOLIPID,
KEYWDS   2 HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    C.Y.CHUANG,T.P.KO,A.H.J.WANG,M.H.HOU
REVDAT   1   24-JUN-15 4QNN    0
JRNL        AUTH   C.Y.CHUANG,T.P.KO,A.H.J.WANG,M.H.HOU
JRNL        TITL   CRYSTAL STRUCTURE OF PHOSPHOLIPASE A 1 FROM HORNET(VESPA
JRNL        TITL 2 BASALIS) VENOM
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    2.50 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : CNS 1.1
REMARK   3   AUTHORS     : BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE-
REMARK   3               : KUNSTLEVE,JIANG,KUSZEWSKI,NILGES,PANNU,
REMARK   3               : READ,RICE,SIMONSON,WARREN
REMARK   3
REMARK   3  REFINEMENT TARGET : ENGH & HUBER
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.50
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 25.00
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000
REMARK   3   DATA CUTOFF HIGH         (ABS(F)) : NULL
REMARK   3   DATA CUTOFF LOW          (ABS(F)) : NULL
REMARK   3   COMPLETENESS (WORKING+TEST)   (%) : NULL
REMARK   3   NUMBER OF REFLECTIONS             : 35409
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : NULL
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE            (WORKING SET) : 0.204
REMARK   3   FREE R VALUE                     : 0.279
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : NULL
REMARK   3   FREE R VALUE TEST SET COUNT      : 1936
REMARK   3   ESTIMATED ERROR OF FREE R VALUE  : NULL
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : NULL
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : NULL
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : NULL
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : NULL
REMARK   3   REFLECTIONS IN BIN    (WORKING SET) : NULL
REMARK   3   BIN R VALUE           (WORKING SET) : NULL
REMARK   3   BIN FREE R VALUE                    : NULL
REMARK   3   BIN FREE R VALUE TEST SET SIZE  (%) : NULL
REMARK   3   BIN FREE R VALUE TEST SET COUNT     : NULL
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE : NULL
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 9168
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 27
REMARK   3   SOLVENT ATOMS            : 477
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  ESTIMATED COORDINATE ERROR.
REMARK   3   ESD FROM LUZZATI PLOT        (A) : NULL
REMARK   3   ESD FROM SIGMAA              (A) : NULL
REMARK   3   LOW RESOLUTION CUTOFF        (A) : NULL
REMARK   3
REMARK   3  CROSS-VALIDATED ESTIMATED COORDINATE ERROR.
REMARK   3   ESD FROM C-V LUZZATI PLOT    (A) : NULL
REMARK   3   ESD FROM C-V SIGMAA          (A) : NULL
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES.
REMARK   3   BOND LENGTHS                 (A) : NULL
REMARK   3   BOND ANGLES            (DEGREES) : NULL
REMARK   3   DIHEDRAL ANGLES        (DEGREES) : NULL
REMARK   3   IMPROPER ANGLES        (DEGREES) : NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL MODEL : NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.    RMS    SIGMA
REMARK   3   MAIN-CHAIN BOND              (A**2) : 1.270 ; NULL
REMARK   3   MAIN-CHAIN ANGLE             (A**2) : 2.166 ; NULL
REMARK   3   SIDE-CHAIN BOND              (A**2) : NULL  ; NULL
REMARK   3   SIDE-CHAIN ANGLE             (A**2) : NULL  ; NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELING.
REMARK   3   METHOD USED : NULL
REMARK   3   KSOL        : NULL
REMARK   3   BSOL        : NULL
REMARK   3
REMARK   3  NCS MODEL : NULL
REMARK   3
REMARK   3  NCS RESTRAINTS.                         RMS   SIGMA/WEIGHT
REMARK   3   GROUP  1  POSITIONAL            (A) : NULL  ; NULL
REMARK   3   GROUP  1  B-FACTOR           (A**2) : NULL  ; NULL
REMARK   3
REMARK   3  PARAMETER FILE  1  : NULL
REMARK   3  TOPOLOGY FILE  1   : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 4QNN COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 26-JUN-14.
REMARK 100 THE RCSB ID CODE IS RCSB086282.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 07-MAY-04
REMARK 200  TEMPERATURE           (KELVIN) : 110
REMARK 200  PH                             : 8.0
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : NSRRC
REMARK 200  BEAMLINE                       : BL17B2
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.5418
REMARK 200  MONOCHROMATOR                  : WATER-COOLED, FIXED-EXIT DOUBLE
REMARK 200                                   CRYSTAL MONOCHROMATOR
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : SCINTILLATION COUNTER
REMARK 200  DETECTOR MANUFACTURER          : NULL
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 35849
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.500
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 0.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 96.5
REMARK 200  DATA REDUNDANCY                : NULL
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : NULL
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.50
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.59
REMARK 200  COMPLETENESS FOR SHELL     (%) : 95.0
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: REFMAC
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 41.42
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.10
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.2M SODIUM ACETATE TRIHYDRATE, 0.1M
REMARK 280  TRIS HCL PH 8.0, 25% PEG4000 500ML PRECIPITATION, VAPOR
REMARK 280  DIFFUSION, SITTING DROP, TEMPERATURE 298K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 7770 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 44760 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -341.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, C, B, D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     PHE A     1
REMARK 465     ASN A     2
REMARK 465     ILE A   300
REMARK 465     PHE B     1
REMARK 465     ASN B     2
REMARK 465     ILE B   300
REMARK 465     PHE C     1
REMARK 465     ASN C     2
REMARK 465     ILE C   300
REMARK 465     PHE D     1
REMARK 465     ASN D     2
REMARK 465     ILE D   300
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     HIS A 242    CB   CG   ND1  CD2  CE1  NE2
REMARK 470     HIS B 242    CB   CG   ND1  CD2  CE1  NE2
REMARK 470     HIS C 242    CB   CG   ND1  CD2  CE1  NE2
REMARK 470     HIS D 242    CB   CG   ND1  CD2  CE1  NE2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   O    ASN A   211     O    HOH A   525              2.00
REMARK 500   O    ASN A   295     O    HOH A   576              2.02
REMARK 500   NZ   LYS A   241     O    HOH A   513              2.07
REMARK 500   O    PRO A   221     O    HOH A   540              2.09
REMARK 500   NE2  HIS D   196     O    HOH D   623              2.12
REMARK 500   NE2  HIS A   196     O    HOH A   501              2.13
REMARK 500   O    ASN D   211     O    HOH D   563              2.17
REMARK 500   O    HOH D   596     O    HOH D   626              2.17
REMARK 500   OH   TYR A   101     O    HOH A   555              2.18
REMARK 500  CL     CL B   402     O    HOH A   577              2.18
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    PRO A   5   C   -  N   -  CA  ANGL. DEV. =  13.2 DEGREES
REMARK 500    PRO B   5   C   -  N   -  CA  ANGL. DEV. =  12.4 DEGREES
REMARK 500    CYS B  87   CA  -  CB  -  SG  ANGL. DEV. =   7.4 DEGREES
REMARK 500    PRO C   5   C   -  N   -  CA  ANGL. DEV. =   9.6 DEGREES
REMARK 500    CYS C 227   CA  -  CB  -  SG  ANGL. DEV. =   8.8 DEGREES
REMARK 500    PRO D   5   C   -  N   -  CA  ANGL. DEV. =  11.0 DEGREES
REMARK 500    PRO D 221   C   -  N   -  CA  ANGL. DEV. =   9.1 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    SER A   7      137.72   -170.48
REMARK 500    GLU A  19       50.44   -105.37
REMARK 500    ASN A  20       66.75   -176.59
REMARK 500    LYS A  22      109.91    -53.43
REMARK 500    PHE A  53      131.26    -37.76
REMARK 500    ASP A  58       38.42    -92.86
REMARK 500    ASN A  74       54.85   -100.91
REMARK 500    GLU A  90       -2.55   -160.82
REMARK 500    MET A  91       87.31    -21.95
REMARK 500    ILE A  94       87.74    -49.21
REMARK 500    SER A 137     -112.42     39.27
REMARK 500    ASP A 165       63.67     39.20
REMARK 500    SER A 170        7.36     80.60
REMARK 500    PHE A 171      -40.23   -142.12
REMARK 500    LYS A 172      -53.13    -26.80
REMARK 500    ASN A 211      -52.87    104.24
REMARK 500    PRO A 221      -41.96    -29.58
REMARK 500    ARG A 263       -6.92    -55.04
REMARK 500    TYR A 292      -19.95     62.23
REMARK 500    CYS A 293      137.19    -30.53
REMARK 500    SER B   7      140.82   -176.86
REMARK 500    ASN B  20       69.39   -171.67
REMARK 500    HIS B  23       48.22    -75.50
REMARK 500    THR B  30        5.03    -62.12
REMARK 500    ASP B  58       41.64    -92.00
REMARK 500    GLU B  89       42.80    -83.74
REMARK 500    GLU B  90       13.35    175.50
REMARK 500    MET B  91       79.56    -44.93
REMARK 500    SER B  92       73.01   -117.87
REMARK 500    ILE B  94       75.14    -27.38
REMARK 500    SER B 137     -111.03     48.07
REMARK 500    ASP B 165       68.43     36.43
REMARK 500    SER B 170        1.90     86.53
REMARK 500    PHE B 171      -35.76   -137.06
REMARK 500    LYS B 172      -63.67    -27.91
REMARK 500    THR B 193      -34.00   -133.62
REMARK 500    ASN B 211      -58.44    105.69
REMARK 500    PRO B 221      -50.37    -18.01
REMARK 500    ARG B 263        0.51    -69.24
REMARK 500    TYR B 292      -14.86     61.27
REMARK 500    CYS B 293      141.45    -36.98
REMARK 500    ASN B 295      147.93    176.10
REMARK 500    ASN C  20       77.71   -158.81
REMARK 500    ASP C  29      -73.60    -89.72
REMARK 500    THR C  30       -0.18    -58.30
REMARK 500    SER C  55     -168.33   -127.30
REMARK 500    ASP C  58       49.75    -82.85
REMARK 500    ASN C  74       45.18    -96.18
REMARK 500    GLU C  89       35.85    -70.12
REMARK 500    GLU C  90       31.04    177.02
REMARK 500
REMARK 500 THIS ENTRY HAS      79 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: PLANAR GROUPS
REMARK 500
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS
REMARK 500 AN RMSD GREATER THAN THIS VALUE
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500  M RES CSSEQI        RMS     TYPE
REMARK 500    TYR B   6         0.07    SIDE CHAIN
REMARK 500    TYR B 283         0.08    SIDE CHAIN
REMARK 500    TYR C   6         0.07    SIDE CHAIN
REMARK 500    TYR D   6         0.07    SIDE CHAIN
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH A 554        DISTANCE =  7.39 ANGSTROMS
REMARK 525    HOH A 558        DISTANCE =  5.05 ANGSTROMS
REMARK 525    HOH A 567        DISTANCE =  5.27 ANGSTROMS
REMARK 525    HOH A 568        DISTANCE =  5.03 ANGSTROMS
REMARK 525    HOH A 569        DISTANCE =  6.16 ANGSTROMS
REMARK 525    HOH A 570        DISTANCE =  5.74 ANGSTROMS
REMARK 525    HOH A 609        DISTANCE =  5.14 ANGSTROMS
REMARK 525    HOH B 514        DISTANCE =  5.27 ANGSTROMS
REMARK 525    HOH B 517        DISTANCE =  5.51 ANGSTROMS
REMARK 525    HOH B 519        DISTANCE =  5.13 ANGSTROMS
REMARK 525    HOH B 538        DISTANCE =  5.50 ANGSTROMS
REMARK 525    HOH B 539        DISTANCE =  6.83 ANGSTROMS
REMARK 525    HOH B 542        DISTANCE =  7.68 ANGSTROMS
REMARK 525    HOH B 551        DISTANCE =  6.81 ANGSTROMS
REMARK 525    HOH B 554        DISTANCE =  8.52 ANGSTROMS
REMARK 525    HOH B 557        DISTANCE =  8.89 ANGSTROMS
REMARK 525    HOH B 559        DISTANCE =  7.56 ANGSTROMS
REMARK 525    HOH B 560        DISTANCE =  8.24 ANGSTROMS
REMARK 525    HOH B 600        DISTANCE =  5.78 ANGSTROMS
REMARK 525    HOH B 607        DISTANCE =  6.30 ANGSTROMS
REMARK 525    HOH C 601        DISTANCE =  6.40 ANGSTROMS
REMARK 525    HOH C 618        DISTANCE =  5.12 ANGSTROMS
REMARK 525    HOH C 628        DISTANCE =  5.25 ANGSTROMS
REMARK 525    HOH C 666        DISTANCE =  6.52 ANGSTROMS
REMARK 525    HOH C 670        DISTANCE =  6.46 ANGSTROMS
REMARK 525    HOH C 677        DISTANCE =  5.34 ANGSTROMS
REMARK 525    HOH C 680        DISTANCE =  8.19 ANGSTROMS
REMARK 525    HOH C 681        DISTANCE =  6.69 ANGSTROMS
REMARK 525    HOH C 685        DISTANCE =  7.16 ANGSTROMS
REMARK 525    HOH C 696        DISTANCE =  6.93 ANGSTROMS
REMARK 525    HOH C 709        DISTANCE =  9.21 ANGSTROMS
REMARK 525    HOH C 715        DISTANCE =  5.76 ANGSTROMS
REMARK 525    HOH C 717        DISTANCE = 11.38 ANGSTROMS
REMARK 525    HOH D 544        DISTANCE =  5.60 ANGSTROMS
REMARK 525    HOH D 547        DISTANCE =  5.99 ANGSTROMS
REMARK 525    HOH D 548        DISTANCE =  6.98 ANGSTROMS
REMARK 525    HOH D 554        DISTANCE =  9.73 ANGSTROMS
REMARK 525    HOH D 561        DISTANCE =  5.74 ANGSTROMS
REMARK 525    HOH D 568        DISTANCE =  5.21 ANGSTROMS
REMARK 525    HOH D 579        DISTANCE =  5.78 ANGSTROMS
REMARK 525    HOH D 580        DISTANCE =  7.06 ANGSTROMS
REMARK 525    HOH D 601        DISTANCE =  8.74 ANGSTROMS
REMARK 525    HOH D 613        DISTANCE =  6.19 ANGSTROMS
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL A 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL A 402
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL A 403
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL A 404
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE HG A 406
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 402
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 403
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 404
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 405
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 406
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 407
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 408
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 409
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 410
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 411
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 412
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE HG B 413
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL C 501
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL C 502
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL C 503
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL C 504
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE HG C 505
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL D 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL D 402
REMARK 800
REMARK 800 SITE_IDENTIFIER: CC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL D 403
REMARK 999
REMARK 999 SEQUENCE
REMARK 999 THE SEQUENCE OF THIS PROTEIN WAS NOT AVAILABLE AT THE UNIPROT
REMARK 999 KNOWLEDGEBASE DATABASE (UNIPROTKB) AT THE TIME OF DEPOSITION.
DBREF  4QNN A    1   300  PDB    4QNN     4QNN             1    300
DBREF  4QNN B    1   300  PDB    4QNN     4QNN             1    300
DBREF  4QNN C    1   300  PDB    4QNN     4QNN             1    300
DBREF  4QNN D    1   300  PDB    4QNN     4QNN             1    300
SEQRES   1 A  300  PHE ASN PRO CYS PRO TYR SER ASP ASP THR VAL LYS MET
SEQRES   2 A  300  ILE ILE LEU THR ARG GLU ASN LYS LYS HIS ASP PHE TYR
SEQRES   3 A  300  THR LEU ASP THR ILE LYS LYS HIS ASN GLU PHE LYS LYS
SEQRES   4 A  300  SER THR ILE LYS HIS GLN VAL VAL PHE ILE THR HIS GLY
SEQRES   5 A  300  PHE THR SER SER ALA ASP THR GLU ASN PHE LEU ALA MET
SEQRES   6 A  300  ALA LYS ALA LEU SER ASP LYS GLY ASN TYR LEU VAL ILE
SEQRES   7 A  300  LEU ILE ASP TRP ARG VAL ALA ALA CYS THR GLU GLU MET
SEQRES   8 A  300  SER GLY ILE GLN LEU ALA TYR TYR SER TYR ALA ALA SER
SEQRES   9 A  300  ASN THR ARG LEU VAL GLY ASN TYR ILE ALA THR VAL THR
SEQRES  10 A  300  LYS MET LEU VAL GLN LYS TYR ASN VAL PRO MET ALA ASN
SEQRES  11 A  300  ILE ARG LEU ILE GLY HIS SER LEU GLY ALA HIS THR SER
SEQRES  12 A  300  GLY PHE ALA GLY LYS LYS VAL GLN GLU LEU GLY LEU GLY
SEQRES  13 A  300  LYS TYR SER GLU ILE ILE GLY LEU ASP PRO ALA GLY PRO
SEQRES  14 A  300  SER PHE LYS SER ASN ASP CYS SER GLU ARG ILE CYS LYS
SEQRES  15 A  300  THR ASP ALA HIS TYR VAL GLN ILE ILE HIS THR SER ASN
SEQRES  16 A  300  HIS LEU GLY THR LEU VAL THR LEU GLY THR VAL ASP PHE
SEQRES  17 A  300  MET ASN ASN GLY TYR ASN GLN PRO GLY CYS GLY LEU PRO
SEQRES  18 A  300  LEU ILE GLY GLU THR CYS SER HIS THR ARG ALA VAL LYS
SEQRES  19 A  300  TYR PHE THR GLU CYS ILE LYS HIS GLU CYS CYS LEU ILE
SEQRES  20 A  300  GLY VAL PRO GLN SER LYS LYS PRO GLN PRO VAL SER LYS
SEQRES  21 A  300  CYS THR ARG ASN GLU CYS VAL CYS VAL GLY LEU ASN ALA
SEQRES  22 A  300  LYS THR TYR PRO LYS THR GLY SER PHE TYR VAL PRO VAL
SEQRES  23 A  300  GLU SER LYS ALA PRO TYR CYS ASN ASN LYS GLY LYS ILE
SEQRES  24 A  300  ILE
SEQRES   1 B  300  PHE ASN PRO CYS PRO TYR SER ASP ASP THR VAL LYS MET
SEQRES   2 B  300  ILE ILE LEU THR ARG GLU ASN LYS LYS HIS ASP PHE TYR
SEQRES   3 B  300  THR LEU ASP THR ILE LYS LYS HIS ASN GLU PHE LYS LYS
SEQRES   4 B  300  SER THR ILE LYS HIS GLN VAL VAL PHE ILE THR HIS GLY
SEQRES   5 B  300  PHE THR SER SER ALA ASP THR GLU ASN PHE LEU ALA MET
SEQRES   6 B  300  ALA LYS ALA LEU SER ASP LYS GLY ASN TYR LEU VAL ILE
SEQRES   7 B  300  LEU ILE ASP TRP ARG VAL ALA ALA CYS THR GLU GLU MET
SEQRES   8 B  300  SER GLY ILE GLN LEU ALA TYR TYR SER TYR ALA ALA SER
SEQRES   9 B  300  ASN THR ARG LEU VAL GLY ASN TYR ILE ALA THR VAL THR
SEQRES  10 B  300  LYS MET LEU VAL GLN LYS TYR ASN VAL PRO MET ALA ASN
SEQRES  11 B  300  ILE ARG LEU ILE GLY HIS SER LEU GLY ALA HIS THR SER
SEQRES  12 B  300  GLY PHE ALA GLY LYS LYS VAL GLN GLU LEU GLY LEU GLY
SEQRES  13 B  300  LYS TYR SER GLU ILE ILE GLY LEU ASP PRO ALA GLY PRO
SEQRES  14 B  300  SER PHE LYS SER ASN ASP CYS SER GLU ARG ILE CYS LYS
SEQRES  15 B  300  THR ASP ALA HIS TYR VAL GLN ILE ILE HIS THR SER ASN
SEQRES  16 B  300  HIS LEU GLY THR LEU VAL THR LEU GLY THR VAL ASP PHE
SEQRES  17 B  300  MET ASN ASN GLY TYR ASN GLN PRO GLY CYS GLY LEU PRO
SEQRES  18 B  300  LEU ILE GLY GLU THR CYS SER HIS THR ARG ALA VAL LYS
SEQRES  19 B  300  TYR PHE THR GLU CYS ILE LYS HIS GLU CYS CYS LEU ILE
SEQRES  20 B  300  GLY VAL PRO GLN SER LYS LYS PRO GLN PRO VAL SER LYS
SEQRES  21 B  300  CYS THR ARG ASN GLU CYS VAL CYS VAL GLY LEU ASN ALA
SEQRES  22 B  300  LYS THR TYR PRO LYS THR GLY SER PHE TYR VAL PRO VAL
SEQRES  23 B  300  GLU SER LYS ALA PRO TYR CYS ASN ASN LYS GLY LYS ILE
SEQRES  24 B  300  ILE
SEQRES   1 C  300  PHE ASN PRO CYS PRO TYR SER ASP ASP THR VAL LYS MET
SEQRES   2 C  300  ILE ILE LEU THR ARG GLU ASN LYS LYS HIS ASP PHE TYR
SEQRES   3 C  300  THR LEU ASP THR ILE LYS LYS HIS ASN GLU PHE LYS LYS
SEQRES   4 C  300  SER THR ILE LYS HIS GLN VAL VAL PHE ILE THR HIS GLY
SEQRES   5 C  300  PHE THR SER SER ALA ASP THR GLU ASN PHE LEU ALA MET
SEQRES   6 C  300  ALA LYS ALA LEU SER ASP LYS GLY ASN TYR LEU VAL ILE
SEQRES   7 C  300  LEU ILE ASP TRP ARG VAL ALA ALA CYS THR GLU GLU MET
SEQRES   8 C  300  SER GLY ILE GLN LEU ALA TYR TYR SER TYR ALA ALA SER
SEQRES   9 C  300  ASN THR ARG LEU VAL GLY ASN TYR ILE ALA THR VAL THR
SEQRES  10 C  300  LYS MET LEU VAL GLN LYS TYR ASN VAL PRO MET ALA ASN
SEQRES  11 C  300  ILE ARG LEU ILE GLY HIS SER LEU GLY ALA HIS THR SER
SEQRES  12 C  300  GLY PHE ALA GLY LYS LYS VAL GLN GLU LEU GLY LEU GLY
SEQRES  13 C  300  LYS TYR SER GLU ILE ILE GLY LEU ASP PRO ALA GLY PRO
SEQRES  14 C  300  SER PHE LYS SER ASN ASP CYS SER GLU ARG ILE CYS LYS
SEQRES  15 C  300  THR ASP ALA HIS TYR VAL GLN ILE ILE HIS THR SER ASN
SEQRES  16 C  300  HIS LEU GLY THR LEU VAL THR LEU GLY THR VAL ASP PHE
SEQRES  17 C  300  MET ASN ASN GLY TYR ASN GLN PRO GLY CYS GLY LEU PRO
SEQRES  18 C  300  LEU ILE GLY GLU THR CYS SER HIS THR ARG ALA VAL LYS
SEQRES  19 C  300  TYR PHE THR GLU CYS ILE LYS HIS GLU CYS CYS LEU ILE
SEQRES  20 C  300  GLY VAL PRO GLN SER LYS LYS PRO GLN PRO VAL SER LYS
SEQRES  21 C  300  CYS THR ARG ASN GLU CYS VAL CYS VAL GLY LEU ASN ALA
SEQRES  22 C  300  LYS THR TYR PRO LYS THR GLY SER PHE TYR VAL PRO VAL
SEQRES  23 C  300  GLU SER LYS ALA PRO TYR CYS ASN ASN LYS GLY LYS ILE
SEQRES  24 C  300  ILE
SEQRES   1 D  300  PHE ASN PRO CYS PRO TYR SER ASP ASP THR VAL LYS MET
SEQRES   2 D  300  ILE ILE LEU THR ARG GLU ASN LYS LYS HIS ASP PHE TYR
SEQRES   3 D  300  THR LEU ASP THR ILE LYS LYS HIS ASN GLU PHE LYS LYS
SEQRES   4 D  300  SER THR ILE LYS HIS GLN VAL VAL PHE ILE THR HIS GLY
SEQRES   5 D  300  PHE THR SER SER ALA ASP THR GLU ASN PHE LEU ALA MET
SEQRES   6 D  300  ALA LYS ALA LEU SER ASP LYS GLY ASN TYR LEU VAL ILE
SEQRES   7 D  300  LEU ILE ASP TRP ARG VAL ALA ALA CYS THR GLU GLU MET
SEQRES   8 D  300  SER GLY ILE GLN LEU ALA TYR TYR SER TYR ALA ALA SER
SEQRES   9 D  300  ASN THR ARG LEU VAL GLY ASN TYR ILE ALA THR VAL THR
SEQRES  10 D  300  LYS MET LEU VAL GLN LYS TYR ASN VAL PRO MET ALA ASN
SEQRES  11 D  300  ILE ARG LEU ILE GLY HIS SER LEU GLY ALA HIS THR SER
SEQRES  12 D  300  GLY PHE ALA GLY LYS LYS VAL GLN GLU LEU GLY LEU GLY
SEQRES  13 D  300  LYS TYR SER GLU ILE ILE GLY LEU ASP PRO ALA GLY PRO
SEQRES  14 D  300  SER PHE LYS SER ASN ASP CYS SER GLU ARG ILE CYS LYS
SEQRES  15 D  300  THR ASP ALA HIS TYR VAL GLN ILE ILE HIS THR SER ASN
SEQRES  16 D  300  HIS LEU GLY THR LEU VAL THR LEU GLY THR VAL ASP PHE
SEQRES  17 D  300  MET ASN ASN GLY TYR ASN GLN PRO GLY CYS GLY LEU PRO
SEQRES  18 D  300  LEU ILE GLY GLU THR CYS SER HIS THR ARG ALA VAL LYS
SEQRES  19 D  300  TYR PHE THR GLU CYS ILE LYS HIS GLU CYS CYS LEU ILE
SEQRES  20 D  300  GLY VAL PRO GLN SER LYS LYS PRO GLN PRO VAL SER LYS
SEQRES  21 D  300  CYS THR ARG ASN GLU CYS VAL CYS VAL GLY LEU ASN ALA
SEQRES  22 D  300  LYS THR TYR PRO LYS THR GLY SER PHE TYR VAL PRO VAL
SEQRES  23 D  300  GLU SER LYS ALA PRO TYR CYS ASN ASN LYS GLY LYS ILE
SEQRES  24 D  300  ILE
HET     CL  A 401       1
HET     CL  A 402       1
HET     CL  A 403       1
HET     CL  A 404       1
HET     CL  A 405       1
HET     HG  A 406       1
HET     CL  B 401       1
HET     CL  B 402       1
HET     CL  B 403       1
HET     CL  B 404       1
HET     CL  B 405       1
HET     CL  B 406       1
HET     CL  B 407       1
HET     CL  B 408       1
HET     CL  B 409       1
HET     CL  B 410       1
HET     CL  B 411       1
HET     CL  B 412       1
HET     HG  B 413       1
HET     CL  C 501       1
HET     CL  C 502       1
HET     CL  C 503       1
HET     CL  C 504       1
HET     HG  C 505       1
HET     CL  D 401       1
HET     CL  D 402       1
HET     CL  D 403       1
HETNAM      CL CHLORIDE ION
HETNAM      HG MERCURY (II) ION
FORMUL   5   CL    24(CL 1-)
FORMUL  10   HG    3(HG 2+)
FORMUL  32  HOH   *477(H2 O)
HELIX    1   1 SER A    7  VAL A   11  5                                   5
HELIX    2   2 ASP A   29  LYS A   38  5                                  10
HELIX    3   3 THR A   59  ASP A   71  1                                  13
HELIX    4   4 ILE A   94  ASN A  125  1                                  32
HELIX    5   5 PRO A  127  ALA A  129  5                                   3
HELIX    6   6 SER A  137  LEU A  153  1                                  17
HELIX    7   7 ASP A  175  ARG A  179  5                                   5
HELIX    8   8 GLY A  224  HIS A  242  1                                  19
HELIX    9   9 ASN A  272  TYR A  276  5                                   5
HELIX   10  10 SER B    7  VAL B   11  5                                   5
HELIX   11  11 ASP B   29  LYS B   38  5                                  10
HELIX   12  12 THR B   59  ASP B   71  1                                  13
HELIX   13  13 CYS B   87  MET B   91  5                                   5
HELIX   14  14 ILE B   94  ASN B  125  1                                  32
HELIX   15  15 PRO B  127  ALA B  129  5                                   3
HELIX   16  16 LEU B  138  LEU B  153  1                                  16
HELIX   17  17 ASP B  175  ARG B  179  5                                   5
HELIX   18  18 GLY B  224  HIS B  242  1                                  19
HELIX   19  19 PRO B  257  CYS B  261  5                                   5
HELIX   20  20 ASN B  272  TYR B  276  5                                   5
HELIX   21  21 SER C    7  VAL C   11  5                                   5
HELIX   22  22 ASP C   29  LYS C   39  5                                  11
HELIX   23  23 THR C   59  ASP C   71  1                                  13
HELIX   24  24 CYS C   87  MET C   91  5                                   5
HELIX   25  25 ILE C   94  ASN C  125  1                                  32
HELIX   26  26 PRO C  127  ALA C  129  5                                   3
HELIX   27  27 SER C  137  LEU C  153  1                                  17
HELIX   28  28 ASP C  175  ARG C  179  5                                   5
HELIX   29  29 CYS C  181  THR C  183  5                                   3
HELIX   30  30 GLY C  224  HIS C  242  1                                  19
HELIX   31  31 PRO C  257  CYS C  261  5                                   5
HELIX   32  32 ASN C  272  TYR C  276  5                                   5
HELIX   33  33 SER D    7  VAL D   11  5                                   5
HELIX   34  34 ASP D   29  LYS D   38  5                                  10
HELIX   35  35 THR D   59  ASP D   71  1                                  13
HELIX   36  36 CYS D   87  MET D   91  5                                   5
HELIX   37  37 ILE D   94  ASN D  125  1                                  32
HELIX   38  38 PRO D  127  ALA D  129  5                                   3
HELIX   39  39 SER D  137  LEU D  153  1                                  17
HELIX   40  40 ASP D  175  ARG D  179  5                                   5
HELIX   41  41 GLY D  224  HIS D  242  1                                  19
HELIX   42  42 PRO D  257  CYS D  261  5                                   5
HELIX   43  43 ASN D  272  TYR D  276  5                                   5
SHEET    1   A11 PHE A  25  TYR A  26  0
SHEET    2   A11 LYS A  12  LEU A  16 -1  N  MET A  13   O  TYR A  26
SHEET    3   A11 TYR A  75  ASP A  81 -1  O  VAL A  77   N  LEU A  16
SHEET    4   A11 GLN A  45  THR A  50  1  N  ILE A  49   O  ILE A  80
SHEET    5   A11 ILE A 131  HIS A 136  1  O  ARG A 132   N  PHE A  48
SHEET    6   A11 TYR A 158  LEU A 164  1  O  LEU A 164   N  GLY A 135
SHEET    7   A11 ALA A 185  HIS A 192  1  O  GLN A 189   N  GLY A 163
SHEET    8   A11 VAL A 206  MET A 209  1  O  PHE A 208   N  ILE A 190
SHEET    9   A11 GLY A 280  TYR A 283  1  O  PHE A 282   N  MET A 209
SHEET   10   A11 ILE A 247  PRO A 250 -1  N  VAL A 249   O  TYR A 283
SHEET   11   A11 VAL A 267  CYS A 268 -1  O  VAL A 267   N  GLY A 248
SHEET    1   B10 LYS B  12  LEU B  16  0
SHEET    2   B10 TYR B  75  ASP B  81 -1  O  VAL B  77   N  LEU B  16
SHEET    3   B10 GLN B  45  THR B  50  1  N  GLN B  45   O  LEU B  76
SHEET    4   B10 ILE B 131  HIS B 136  1  O  ILE B 134   N  THR B  50
SHEET    5   B10 TYR B 158  LEU B 164  1  O  LEU B 164   N  GLY B 135
SHEET    6   B10 ALA B 185  HIS B 192  1  O  ILE B 191   N  GLY B 163
SHEET    7   B10 VAL B 206  MET B 209  1  O  PHE B 208   N  ILE B 190
SHEET    8   B10 GLY B 280  TYR B 283  1  O  PHE B 282   N  MET B 209
SHEET    9   B10 ILE B 247  PRO B 250 -1  N  VAL B 249   O  TYR B 283
SHEET   10   B10 VAL B 267  CYS B 268 -1  O  VAL B 267   N  GLY B 248
SHEET    1   C10 LYS C  12  LEU C  16  0
SHEET    2   C10 TYR C  75  ASP C  81 -1  O  VAL C  77   N  LEU C  16
SHEET    3   C10 GLN C  45  THR C  50  1  N  GLN C  45   O  LEU C  76
SHEET    4   C10 ILE C 131  HIS C 136  1  O  ARG C 132   N  PHE C  48
SHEET    5   C10 TYR C 158  LEU C 164  1  O  ILE C 162   N  LEU C 133
SHEET    6   C10 ALA C 185  HIS C 192  1  O  TYR C 187   N  ILE C 161
SHEET    7   C10 VAL C 206  MET C 209  1  O  PHE C 208   N  HIS C 192
SHEET    8   C10 GLY C 280  TYR C 283  1  O  GLY C 280   N  ASP C 207
SHEET    9   C10 ILE C 247  PRO C 250 -1  N  VAL C 249   O  TYR C 283
SHEET   10   C10 VAL C 267  CYS C 268 -1  O  VAL C 267   N  GLY C 248
SHEET    1   D10 LYS D  12  LEU D  16  0
SHEET    2   D10 TYR D  75  ASP D  81 -1  O  VAL D  77   N  LEU D  16
SHEET    3   D10 GLN D  45  THR D  50  1  N  ILE D  49   O  ILE D  80
SHEET    4   D10 ILE D 131  HIS D 136  1  O  ILE D 134   N  PHE D  48
SHEET    5   D10 GLU D 160  LEU D 164  1  O  ILE D 162   N  LEU D 133
SHEET    6   D10 VAL D 188  HIS D 192  1  O  GLN D 189   N  GLY D 163
SHEET    7   D10 VAL D 206  MET D 209  1  O  PHE D 208   N  HIS D 192
SHEET    8   D10 GLY D 280  TYR D 283  1  O  PHE D 282   N  MET D 209
SHEET    9   D10 ILE D 247  PRO D 250 -1  N  VAL D 249   O  TYR D 283
SHEET   10   D10 VAL D 267  CYS D 268 -1  O  VAL D 267   N  GLY D 248
SSBOND   1 CYS A    4    CYS A   87                          1555   1555  2.02
SSBOND   2 CYS A  176    CYS A  181                          1555   1555  2.05
SSBOND   3 CYS A  218    CYS A  227                          1555   1555  2.05
SSBOND   4 CYS A  244    CYS A  268                          1555   1555  2.05
SSBOND   5 CYS A  245    CYS A  293                          1555   1555  2.05
SSBOND   6 CYS A  261    CYS A  266                          1555   1555  2.03
SSBOND   7 CYS B    4    CYS B   87                          1555   1555  2.02
SSBOND   8 CYS B  176    CYS B  181                          1555   1555  2.04
SSBOND   9 CYS B  218    CYS B  227                          1555   1555  2.04
SSBOND  10 CYS B  244    CYS B  268                          1555   1555  2.04
SSBOND  11 CYS B  245    CYS B  293                          1555   1555  2.04
SSBOND  12 CYS B  261    CYS B  266                          1555   1555  2.03
SSBOND  13 CYS C    4    CYS C   87                          1555   1555  2.03
SSBOND  14 CYS C  176    CYS C  181                          1555   1555  2.04
SSBOND  15 CYS C  218    CYS C  227                          1555   1555  2.03
SSBOND  16 CYS C  244    CYS C  268                          1555   1555  2.04
SSBOND  17 CYS C  245    CYS C  293                          1555   1555  2.04
SSBOND  18 CYS C  261    CYS C  266                          1555   1555  2.05
SSBOND  19 CYS D    4    CYS D   87                          1555   1555  2.02
SSBOND  20 CYS D  176    CYS D  181                          1555   1555  2.05
SSBOND  21 CYS D  218    CYS D  227                          1555   1555  2.03
SSBOND  22 CYS D  244    CYS D  268                          1555   1555  2.06
SSBOND  23 CYS D  245    CYS D  293                          1555   1555  2.04
SSBOND  24 CYS D  261    CYS D  266                          1555   1555  2.02
LINK         ND2 ASN B 272                HG    HG B 413     1555   1555  2.70
LINK        HG    HG A 406                 O   HOH A 577     1555   1555  2.91
CISPEP   1 ASN A  211    GLY A  212          0        -1.83
CISPEP   2 ALA A  290    PRO A  291          0         0.55
CISPEP   3 ASN B  211    GLY B  212          0        -1.65
CISPEP   4 ALA B  290    PRO B  291          0         0.09
CISPEP   5 ASN C  211    GLY C  212          0         1.43
CISPEP   6 ALA C  290    PRO C  291          0         0.02
CISPEP   7 ASN D  211    GLY D  212          0        -0.90
CISPEP   8 ALA D  290    PRO D  291          0         0.53
SITE     1 AC1  3 LYS A 241   HG A 406   CL B 402
SITE     1 AC2  5 LYS A 298  HOH A 577   CL B 402   CL B 407
SITE     2 AC2  5  HG B 413
SITE     1 AC3  5 GLU A 238  LYS A 241   CL A 404  HOH A 513
SITE     2 AC3  5 HOH C 676
SITE     1 AC4  2  CL A 403  HOH C 676
SITE     1 AC5  4 LYS A 241   CL A 401  HOH A 577   CL B 402
SITE     1 AC6  4 LYS B 241  HIS B 242   CL B 405  HOH C 682
SITE     1 AC7  6  CL A 401   CL A 402   HG A 406  HOH A 577
SITE     2 AC7  6  CL B 407   HG B 413
SITE     1 AC8  4 GLU B 238  LYS B 241   CL B 404   CL B 410
SITE     1 AC9  4 GLU B 238  LYS B 241   CL B 403   CL B 410
SITE     1 BC1  4  CL B 401  HOH C 643  HOH C 682  HOH C 694
SITE     1 BC2  2  CL B 409  HOH C 635
SITE     1 BC3  4  CL A 402  LYS B  72   CL B 402   HG B 413
SITE     1 BC4  4  CL B 411   CL C 502  HOH D 544  HOH D 545
SITE     1 BC5  1  CL B 406
SITE     1 BC6  4 LYS B 241   CL B 403   CL B 404  HOH D 543
SITE     1 BC7  2  CL B 408   CL C 502
SITE     1 BC8  3 LYS B 298  HOH C 682  HOH C 694
SITE     1 BC9  5  CL A 402  GLU B 243  ASN B 272   CL B 402
SITE     2 BC9  5  CL B 407
SITE     1 CC1  4 LYS C 298   CL C 502   CL C 504   HG C 505
SITE     1 CC2  5  CL B 408   CL B 411   CL C 501   CL C 504
SITE     2 CC2  5  HG C 505
SITE     1 CC3  1 GLU C 238
SITE     1 CC4  3  CL C 501   CL C 502   HG C 505
SITE     1 CC5  4 HIS C 242   CL C 501   CL C 502   CL C 504
SITE     1 CC6  1 HOH C 650
SITE     1 CC7  1  CL D 403
SITE     1 CC8  4 GLU D 238   CL D 402  HOH D 592  HOH D 597
CRYST1   57.276   70.147   81.724 107.14 109.99 100.90 P 1           4
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.017459  0.003362  0.008317        0.00000
SCALE2      0.000000  0.014518  0.006138        0.00000
SCALE3      0.000000  0.000000  0.014137        0.00000
TER    2293      ILE A 299
TER    4586      ILE B 299
TER    6879      ILE C 299
TER    9172      ILE D 299
MASTER      528    0   27   43   41    0   31    6 9672    4   52   96
END