longtext: 4X00-pdb

content
HEADER    HYDROLASE                               20-NOV-14   4X00
TITLE     X-RAY CRYSTAL STRUCTURE OF A PUTATIVE ARYL ESTERASE FROM BURKHOLDERIA
TITLE    2 CENOCEPACIA
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: PUTATIVE HYDROLASE;
COMPND   3 CHAIN: A, B, C, D;
COMPND   4 FRAGMENT: UNP RESIDUES 28-302;
COMPND   5 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: BURKHOLDERIA CENOCEPACIA;
SOURCE   3 ORGANISM_TAXID: 216591;
SOURCE   4 STRAIN: ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 /
SOURCE   5 CF5610;
SOURCE   6 GENE: BCAL2527;
SOURCE   7 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   8 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE   9 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);
SOURCE  10 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID
KEYWDS    HYDROLASE, ARYL ESTERASE, STRUCTURAL GENOMICS, SEATTLE STRUCTURAL
KEYWDS   2 GENOMICS CENTER FOR INFECTIOUS DISEASE, SSGCID
EXPDTA    X-RAY DIFFRACTION
AUTHOR    SEATTLE STRUCTURAL GENOMICS CENTER FOR INFECTIOUS DISEASE (SSGCID)
REVDAT   1   03-DEC-14 4X00    0
JRNL        AUTH   J.W.FAIRMAN,T.E.EDWARDS,D.LORIMER
JRNL        TITL   X-RAY CRYSTAL STRUCTURE OF A PUTATIVE ARYL ESTERASE FROM
JRNL        TITL 2 BURKHOLDERIA CENOCEPACIA
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    1.38 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : ML
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.38
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 46.03
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.360
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.8
REMARK   3   NUMBER OF REFLECTIONS             : 211239
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.138
REMARK   3   R VALUE            (WORKING SET) : 0.137
REMARK   3   FREE R VALUE                     : 0.166
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.940
REMARK   3   FREE R VALUE TEST SET COUNT      : 10430
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 46.0501 -  4.2867    0.99     6822   344  0.1386 0.1444
REMARK   3     2  4.2867 -  3.4028    1.00     6786   353  0.1340 0.1496
REMARK   3     3  3.4028 -  2.9727    1.00     6700   345  0.1434 0.1477
REMARK   3     4  2.9727 -  2.7010    1.00     6719   383  0.1435 0.1670
REMARK   3     5  2.7010 -  2.5074    1.00     6712   369  0.1380 0.1718
REMARK   3     6  2.5074 -  2.3596    1.00     6683   335  0.1330 0.1573
REMARK   3     7  2.3596 -  2.2414    1.00     6772   330  0.1326 0.1673
REMARK   3     8  2.2414 -  2.1438    1.00     6674   356  0.1224 0.1535
REMARK   3     9  2.1438 -  2.0613    1.00     6664   372  0.1264 0.1600
REMARK   3    10  2.0613 -  1.9902    1.00     6711   335  0.1264 0.1558
REMARK   3    11  1.9902 -  1.9279    1.00     6730   334  0.1255 0.1580
REMARK   3    12  1.9279 -  1.8728    1.00     6703   330  0.1263 0.1772
REMARK   3    13  1.8728 -  1.8235    1.00     6686   341  0.1263 0.1710
REMARK   3    14  1.8235 -  1.7790    1.00     6759   296  0.1220 0.1682
REMARK   3    15  1.7790 -  1.7386    1.00     6703   341  0.1221 0.1543
REMARK   3    16  1.7386 -  1.7016    1.00     6665   324  0.1218 0.1704
REMARK   3    17  1.7016 -  1.6675    1.00     6727   345  0.1227 0.1835
REMARK   3    18  1.6675 -  1.6361    1.00     6623   352  0.1242 0.1798
REMARK   3    19  1.6361 -  1.6069    1.00     6657   366  0.1305 0.1848
REMARK   3    20  1.6069 -  1.5796    1.00     6717   326  0.1298 0.1695
REMARK   3    21  1.5796 -  1.5541    1.00     6664   334  0.1308 0.1720
REMARK   3    22  1.5541 -  1.5302    1.00     6689   347  0.1391 0.1817
REMARK   3    23  1.5302 -  1.5077    1.00     6651   375  0.1429 0.1819
REMARK   3    24  1.5077 -  1.4865    1.00     6622   350  0.1532 0.2012
REMARK   3    25  1.4865 -  1.4664    1.00     6717   376  0.1631 0.1952
REMARK   3    26  1.4664 -  1.4473    1.00     6631   366  0.1691 0.1994
REMARK   3    27  1.4473 -  1.4293    1.00     6630   365  0.1713 0.2272
REMARK   3    28  1.4293 -  1.4120    1.00     6681   356  0.1917 0.2324
REMARK   3    29  1.4120 -  1.3956    1.00     6694   329  0.2024 0.2564
REMARK   3    30  1.3956 -  1.3800    1.00     6617   355  0.1956 0.2428
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.110
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 16.020
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 11.06
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 16.61
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.010           8774
REMARK   3   ANGLE     :  1.291          11980
REMARK   3   CHIRALITY :  0.057           1345
REMARK   3   PLANARITY :  0.008           1569
REMARK   3   DIHEDRAL  : 12.634           3235
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 4X00 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 21-NOV-14.
REMARK 100 THE DEPOSITION ID IS D_1000204846.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 13-NOV-13
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 7.5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : APS
REMARK 200  BEAMLINE                       : 21-ID-F
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.97740
REMARK 200  MONOCHROMATOR                  : DIAMOND[111]
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : RAYONIX MX-225
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : NULL
REMARK 200  DATA SCALING SOFTWARE          : XSCALE
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 211257
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.380
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : -3.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.8
REMARK 200  DATA REDUNDANCY                : 3.760
REMARK 200  R MERGE                    (I) : 0.05500
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 14.9500
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.38
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.42
REMARK 200  COMPLETENESS FOR SHELL     (%) : 99.8
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : 0.57600
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 2.270
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: NULL
REMARK 200 SOFTWARE USED: PHENIX
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 43.72
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.19
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: MCSG1 H1: 0.2 M POTASSIUM FLUORIDE,
REMARK 280  20% PEG3350, BUCEA.00095.A.B1.PW37307 AT 26.4 MG/ML
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       40.18500
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3, 4
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 300 REMARK: BIOLOGICAL UNIT IS A MONOMER
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 3
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 4
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A     1
REMARK 465     ALA A     2
REMARK 465     HIS A     3
REMARK 465     HIS A     4
REMARK 465     HIS A     5
REMARK 465     HIS A     6
REMARK 465     HIS A     7
REMARK 465     HIS A     8
REMARK 465     ALA A     9
REMARK 465     ALA A    10
REMARK 465     MET B     1
REMARK 465     ALA B     2
REMARK 465     HIS B     3
REMARK 465     HIS B     4
REMARK 465     HIS B     5
REMARK 465     HIS B     6
REMARK 465     HIS B     7
REMARK 465     HIS B     8
REMARK 465     ALA B     9
REMARK 465     ALA B    10
REMARK 465     ALA B    11
REMARK 465     MET C     1
REMARK 465     ALA C     2
REMARK 465     HIS C     3
REMARK 465     HIS C     4
REMARK 465     HIS C     5
REMARK 465     HIS C     6
REMARK 465     HIS C     7
REMARK 465     HIS C     8
REMARK 465     ALA C     9
REMARK 465     ALA C    10
REMARK 465     MET D     1
REMARK 465     ALA D     2
REMARK 465     HIS D     3
REMARK 465     HIS D     4
REMARK 465     HIS D     5
REMARK 465     HIS D     6
REMARK 465     HIS D     7
REMARK 465     HIS D     8
REMARK 465     ALA D     9
REMARK 465     ALA D    10
REMARK 465     ALA D    11
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     ARG A  12    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG A  58    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG A 104    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LYS A 128    CG   CD   CE   NZ
REMARK 470     LYS A 143    CG   CD   CE   NZ
REMARK 470     ARG A 250    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG A 283    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU B  33    CG   CD   OE1  OE2
REMARK 470     ARG B  58    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG B 104    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LYS B 105    CG   CD   CE   NZ
REMARK 470     ARG B 179    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LYS B 217    CG   CD   CE   NZ
REMARK 470     GLU B 267    CG   CD   OE1  OE2
REMARK 470     ARG B 283    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG C  12    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU C  33    CG   CD   OE1  OE2
REMARK 470     ARG C 104    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LYS C 105    CG   CD   CE   NZ
REMARK 470     LYS C 128    CG   CD   CE   NZ
REMARK 470     ARG C 179    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG C 250    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG C 278    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG D  12    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG D  58    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG D 104    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LYS D 128    CG   CD   CE   NZ
REMARK 470     LYS D 217    CG   CD   CE   NZ
REMARK 470     ARG D 250    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU D 267    CG   CD   OE1  OE2
REMARK 470     ARG D 271    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG D 278    CG   CD   NE   CZ   NH1  NH2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   O    HOH A   419     O    HOH A   451              2.09
REMARK 500   O    HOH A   524     O    HOH A   697              2.13
REMARK 500   NZ   LYS C   236     O    HOH C   703              2.13
REMARK 500   O    HOH C   465     O    HOH C   658              2.15
REMARK 500   O    HOH A   518     O    HOH A   745              2.16
REMARK 500   O    HOH A   402     O    HOH A   457              2.17
REMARK 500   OG   SER D   282     O    HOH D   701              2.18
REMARK 500   O    HOH A   642     O    HOH A   718              2.19
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS
REMARK 500
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.
REMARK 500
REMARK 500 DISTANCE CUTOFF:
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE
REMARK 500   O    HOH A   440     O    HOH C   450     1455     2.02
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    ARG D 170   NE  -  CZ  -  NH1 ANGL. DEV. =  -3.4 DEGREES
REMARK 500    ARG D 170   NE  -  CZ  -  NH2 ANGL. DEV. =   3.9 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    LYS A 105       69.00     32.53
REMARK 500    SER A 112     -111.88     60.83
REMARK 500    ILE A 140      -70.23   -100.21
REMARK 500    SER B 112     -113.12     58.79
REMARK 500    ILE B 140      -70.03   -100.86
REMARK 500    GLU B 210       59.31    -93.30
REMARK 500    SER C 112     -112.90     60.58
REMARK 500    ILE C 140      -68.86    -98.78
REMARK 500    GLU C 210       59.16    -95.60
REMARK 500    SER D 112     -113.79     60.33
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH A 648        DISTANCE =  5.86 ANGSTROMS
REMARK 525    HOH C 589        DISTANCE =  5.89 ANGSTROMS
REMARK 525    HOH D 521        DISTANCE =  8.35 ANGSTROMS
REMARK 525    HOH D 694        DISTANCE =  6.95 ANGSTROMS
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 302
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 303
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 304
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 305
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 306
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 307
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue GOL A 308
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO B 301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO B 302
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO B 303
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue F B 304
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO C 301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO C 302
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue GOL C 303
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue F C 304
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO D 301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO D 302
REMARK 800
REMARK 800 SITE_IDENTIFIER: AE1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue GOL D 303
REMARK 800
REMARK 800 SITE_IDENTIFIER: AE2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue F D 304
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: SSGCID-BUCEA.00095.A   RELATED DB: TARGETTRACK
DBREF  4X00 A    9   283  UNP    B4E794   B4E794_BURCJ    28    302
DBREF  4X00 B    9   283  UNP    B4E794   B4E794_BURCJ    28    302
DBREF  4X00 C    9   283  UNP    B4E794   B4E794_BURCJ    28    302
DBREF  4X00 D    9   283  UNP    B4E794   B4E794_BURCJ    28    302
SEQADV 4X00 MET A    1  UNP  B4E794              INITIATING METHIONINE
SEQADV 4X00 ALA A    2  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 HIS A    3  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 HIS A    4  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 HIS A    5  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 HIS A    6  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 HIS A    7  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 HIS A    8  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 MET B    1  UNP  B4E794              INITIATING METHIONINE
SEQADV 4X00 ALA B    2  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 HIS B    3  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 HIS B    4  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 HIS B    5  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 HIS B    6  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 HIS B    7  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 HIS B    8  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 MET C    1  UNP  B4E794              INITIATING METHIONINE
SEQADV 4X00 ALA C    2  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 HIS C    3  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 HIS C    4  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 HIS C    5  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 HIS C    6  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 HIS C    7  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 HIS C    8  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 MET D    1  UNP  B4E794              INITIATING METHIONINE
SEQADV 4X00 ALA D    2  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 HIS D    3  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 HIS D    4  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 HIS D    5  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 HIS D    6  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 HIS D    7  UNP  B4E794              EXPRESSION TAG
SEQADV 4X00 HIS D    8  UNP  B4E794              EXPRESSION TAG
SEQRES   1 A  283  MET ALA HIS HIS HIS HIS HIS HIS ALA ALA ALA ARG ASP
SEQRES   2 A  283  TYR THR VAL THR ALA PRO ASP GLY VAL VAL LEU ALA VAL
SEQRES   3 A  283  GLN GLU ALA GLY ASP PRO GLU GLY SER PRO ILE ILE PHE
SEQRES   4 A  283  ILE HIS GLY LEU LEU GLY SER ARG LEU ASN TRP SER LYS
SEQRES   5 A  283  GLN LEU GLN ASP PRO ARG LEU GLN HIS TYR ARG LEU ILE
SEQRES   6 A  283  THR TYR ASP LEU ARG GLY HIS GLY LEU SER GLY LYS PRO
SEQRES   7 A  283  ALA GLU ALA SER SER TYR THR ASP GLY ARG ARG TRP ALA
SEQRES   8 A  283  ASP ASP LEU ALA ALA ILE ILE GLU SER THR HIS ALA ARG
SEQRES   9 A  283  LYS PRO VAL LEU VAL GLY TRP SER LEU GLY GLY ALA VAL
SEQRES  10 A  283  ILE SER ASN TYR LEU ALA ALA TYR GLY ASP LYS GLY ILE
SEQRES  11 A  283  ALA GLY ALA VAL TYR VAL ASP GLY VAL ILE GLU LEU LYS
SEQRES  12 A  283  PRO ASP GLN ILE VAL ALA HIS PRO GLU VAL TYR ARG ASP
SEQRES  13 A  283  MET ILE ALA SER ASP LEU GLN THR HIS LEU ASP GLY GLU
SEQRES  14 A  283  ARG ALA PHE LEU ARG LEU CYS PHE HIS ARG GLN PRO ASP
SEQRES  15 A  283  ALA THR THR PHE SER LEU LEU LEU ALA ASN ALA ALA LEU
SEQRES  16 A  283  ALA SER TRP ASP MET GLN ARG ALA VAL ARG SER MET THR
SEQRES  17 A  283  VAL GLU ALA ALA LYS GLY LEU SER LYS ALA GLU VAL PRO
SEQRES  18 A  283  LEU LEU LEU LEU TYR GLY ALA GLN ASP ALA LEU VAL LYS
SEQRES  19 A  283  ALA LYS PRO SER ILE ALA ARG ALA LYS SER LEU ASN PRO
SEQRES  20 A  283  ARG ILE ARG SER GLU LEU TYR ALA ASP SER GLY HIS ALA
SEQRES  21 A  283  PRO PHE LEU GLU GLU PRO GLU ARG PHE ASN ARG ASP LEU
SEQRES  22 A  283  SER ASP PHE VAL ARG MET ALA LEU SER ARG
SEQRES   1 B  283  MET ALA HIS HIS HIS HIS HIS HIS ALA ALA ALA ARG ASP
SEQRES   2 B  283  TYR THR VAL THR ALA PRO ASP GLY VAL VAL LEU ALA VAL
SEQRES   3 B  283  GLN GLU ALA GLY ASP PRO GLU GLY SER PRO ILE ILE PHE
SEQRES   4 B  283  ILE HIS GLY LEU LEU GLY SER ARG LEU ASN TRP SER LYS
SEQRES   5 B  283  GLN LEU GLN ASP PRO ARG LEU GLN HIS TYR ARG LEU ILE
SEQRES   6 B  283  THR TYR ASP LEU ARG GLY HIS GLY LEU SER GLY LYS PRO
SEQRES   7 B  283  ALA GLU ALA SER SER TYR THR ASP GLY ARG ARG TRP ALA
SEQRES   8 B  283  ASP ASP LEU ALA ALA ILE ILE GLU SER THR HIS ALA ARG
SEQRES   9 B  283  LYS PRO VAL LEU VAL GLY TRP SER LEU GLY GLY ALA VAL
SEQRES  10 B  283  ILE SER ASN TYR LEU ALA ALA TYR GLY ASP LYS GLY ILE
SEQRES  11 B  283  ALA GLY ALA VAL TYR VAL ASP GLY VAL ILE GLU LEU LYS
SEQRES  12 B  283  PRO ASP GLN ILE VAL ALA HIS PRO GLU VAL TYR ARG ASP
SEQRES  13 B  283  MET ILE ALA SER ASP LEU GLN THR HIS LEU ASP GLY GLU
SEQRES  14 B  283  ARG ALA PHE LEU ARG LEU CYS PHE HIS ARG GLN PRO ASP
SEQRES  15 B  283  ALA THR THR PHE SER LEU LEU LEU ALA ASN ALA ALA LEU
SEQRES  16 B  283  ALA SER TRP ASP MET GLN ARG ALA VAL ARG SER MET THR
SEQRES  17 B  283  VAL GLU ALA ALA LYS GLY LEU SER LYS ALA GLU VAL PRO
SEQRES  18 B  283  LEU LEU LEU LEU TYR GLY ALA GLN ASP ALA LEU VAL LYS
SEQRES  19 B  283  ALA LYS PRO SER ILE ALA ARG ALA LYS SER LEU ASN PRO
SEQRES  20 B  283  ARG ILE ARG SER GLU LEU TYR ALA ASP SER GLY HIS ALA
SEQRES  21 B  283  PRO PHE LEU GLU GLU PRO GLU ARG PHE ASN ARG ASP LEU
SEQRES  22 B  283  SER ASP PHE VAL ARG MET ALA LEU SER ARG
SEQRES   1 C  283  MET ALA HIS HIS HIS HIS HIS HIS ALA ALA ALA ARG ASP
SEQRES   2 C  283  TYR THR VAL THR ALA PRO ASP GLY VAL VAL LEU ALA VAL
SEQRES   3 C  283  GLN GLU ALA GLY ASP PRO GLU GLY SER PRO ILE ILE PHE
SEQRES   4 C  283  ILE HIS GLY LEU LEU GLY SER ARG LEU ASN TRP SER LYS
SEQRES   5 C  283  GLN LEU GLN ASP PRO ARG LEU GLN HIS TYR ARG LEU ILE
SEQRES   6 C  283  THR TYR ASP LEU ARG GLY HIS GLY LEU SER GLY LYS PRO
SEQRES   7 C  283  ALA GLU ALA SER SER TYR THR ASP GLY ARG ARG TRP ALA
SEQRES   8 C  283  ASP ASP LEU ALA ALA ILE ILE GLU SER THR HIS ALA ARG
SEQRES   9 C  283  LYS PRO VAL LEU VAL GLY TRP SER LEU GLY GLY ALA VAL
SEQRES  10 C  283  ILE SER ASN TYR LEU ALA ALA TYR GLY ASP LYS GLY ILE
SEQRES  11 C  283  ALA GLY ALA VAL TYR VAL ASP GLY VAL ILE GLU LEU LYS
SEQRES  12 C  283  PRO ASP GLN ILE VAL ALA HIS PRO GLU VAL TYR ARG ASP
SEQRES  13 C  283  MET ILE ALA SER ASP LEU GLN THR HIS LEU ASP GLY GLU
SEQRES  14 C  283  ARG ALA PHE LEU ARG LEU CYS PHE HIS ARG GLN PRO ASP
SEQRES  15 C  283  ALA THR THR PHE SER LEU LEU LEU ALA ASN ALA ALA LEU
SEQRES  16 C  283  ALA SER TRP ASP MET GLN ARG ALA VAL ARG SER MET THR
SEQRES  17 C  283  VAL GLU ALA ALA LYS GLY LEU SER LYS ALA GLU VAL PRO
SEQRES  18 C  283  LEU LEU LEU LEU TYR GLY ALA GLN ASP ALA LEU VAL LYS
SEQRES  19 C  283  ALA LYS PRO SER ILE ALA ARG ALA LYS SER LEU ASN PRO
SEQRES  20 C  283  ARG ILE ARG SER GLU LEU TYR ALA ASP SER GLY HIS ALA
SEQRES  21 C  283  PRO PHE LEU GLU GLU PRO GLU ARG PHE ASN ARG ASP LEU
SEQRES  22 C  283  SER ASP PHE VAL ARG MET ALA LEU SER ARG
SEQRES   1 D  283  MET ALA HIS HIS HIS HIS HIS HIS ALA ALA ALA ARG ASP
SEQRES   2 D  283  TYR THR VAL THR ALA PRO ASP GLY VAL VAL LEU ALA VAL
SEQRES   3 D  283  GLN GLU ALA GLY ASP PRO GLU GLY SER PRO ILE ILE PHE
SEQRES   4 D  283  ILE HIS GLY LEU LEU GLY SER ARG LEU ASN TRP SER LYS
SEQRES   5 D  283  GLN LEU GLN ASP PRO ARG LEU GLN HIS TYR ARG LEU ILE
SEQRES   6 D  283  THR TYR ASP LEU ARG GLY HIS GLY LEU SER GLY LYS PRO
SEQRES   7 D  283  ALA GLU ALA SER SER TYR THR ASP GLY ARG ARG TRP ALA
SEQRES   8 D  283  ASP ASP LEU ALA ALA ILE ILE GLU SER THR HIS ALA ARG
SEQRES   9 D  283  LYS PRO VAL LEU VAL GLY TRP SER LEU GLY GLY ALA VAL
SEQRES  10 D  283  ILE SER ASN TYR LEU ALA ALA TYR GLY ASP LYS GLY ILE
SEQRES  11 D  283  ALA GLY ALA VAL TYR VAL ASP GLY VAL ILE GLU LEU LYS
SEQRES  12 D  283  PRO ASP GLN ILE VAL ALA HIS PRO GLU VAL TYR ARG ASP
SEQRES  13 D  283  MET ILE ALA SER ASP LEU GLN THR HIS LEU ASP GLY GLU
SEQRES  14 D  283  ARG ALA PHE LEU ARG LEU CYS PHE HIS ARG GLN PRO ASP
SEQRES  15 D  283  ALA THR THR PHE SER LEU LEU LEU ALA ASN ALA ALA LEU
SEQRES  16 D  283  ALA SER TRP ASP MET GLN ARG ALA VAL ARG SER MET THR
SEQRES  17 D  283  VAL GLU ALA ALA LYS GLY LEU SER LYS ALA GLU VAL PRO
SEQRES  18 D  283  LEU LEU LEU LEU TYR GLY ALA GLN ASP ALA LEU VAL LYS
SEQRES  19 D  283  ALA LYS PRO SER ILE ALA ARG ALA LYS SER LEU ASN PRO
SEQRES  20 D  283  ARG ILE ARG SER GLU LEU TYR ALA ASP SER GLY HIS ALA
SEQRES  21 D  283  PRO PHE LEU GLU GLU PRO GLU ARG PHE ASN ARG ASP LEU
SEQRES  22 D  283  SER ASP PHE VAL ARG MET ALA LEU SER ARG
HET    EDO  A 301       4
HET    EDO  A 302       4
HET    EDO  A 303       4
HET    EDO  A 304       4
HET    EDO  A 305       4
HET    EDO  A 306       4
HET    EDO  A 307       4
HET    GOL  A 308       6
HET    EDO  B 301       4
HET    EDO  B 302       4
HET    EDO  B 303       4
HET      F  B 304       1
HET    EDO  C 301       4
HET    EDO  C 302       4
HET    GOL  C 303       6
HET      F  C 304       1
HET    EDO  D 301       4
HET    EDO  D 302       4
HET    GOL  D 303       6
HET      F  D 304       1
HETNAM     EDO 1,2-ETHANEDIOL
HETNAM     GOL GLYCEROL
HETNAM       F FLUORIDE ION
HETSYN     EDO ETHYLENE GLYCOL
HETSYN     GOL GLYCERIN; PROPANE-1,2,3-TRIOL
FORMUL   5  EDO    14(C2 H6 O2)
FORMUL  12  GOL    3(C3 H8 O3)
FORMUL  16    F    3(F 1-)
FORMUL  25  HOH   *1289(H2 O)
HELIX    1 AA1 SER A   46  ASN A   49  5                                   4
HELIX    2 AA2 TRP A   50  GLN A   55  1                                   6
HELIX    3 AA3 ASP A   56  GLN A   60  5                                   5
HELIX    4 AA4 ALA A   81  ASP A   86  1                                   6
HELIX    5 AA5 ASP A   86  THR A  101  1                                  16
HELIX    6 AA6 LEU A  113  GLY A  126  1                                  14
HELIX    7 AA7 HIS A  150  MET A  157  1                                   8
HELIX    8 AA8 ASP A  161  LEU A  175  1                                  15
HELIX    9 AA9 ASP A  182  LEU A  195  1                                  14
HELIX   10 AB1 SER A  197  ARG A  205  1                                   9
HELIX   11 AB2 GLU A  210  LYS A  217  1                                   8
HELIX   12 AB3 LYS A  234  ASN A  246  1                                  13
HELIX   13 AB4 ALA A  260  GLU A  265  1                                   6
HELIX   14 AB5 GLU A  265  LEU A  281  1                                  17
HELIX   15 AB6 SER B   46  ASN B   49  5                                   4
HELIX   16 AB7 TRP B   50  GLN B   55  1                                   6
HELIX   17 AB8 ARG B   58  HIS B   61  5                                   4
HELIX   18 AB9 ALA B   81  ASP B   86  1                                   6
HELIX   19 AC1 ASP B   86  HIS B  102  1                                  17
HELIX   20 AC2 LEU B  113  GLY B  126  1                                  14
HELIX   21 AC3 HIS B  150  MET B  157  1                                   8
HELIX   22 AC4 ASP B  161  CYS B  176  1                                  16
HELIX   23 AC5 ASP B  182  LEU B  195  1                                  14
HELIX   24 AC6 SER B  197  VAL B  204  1                                   8
HELIX   25 AC7 ARG B  205  MET B  207  5                                   3
HELIX   26 AC8 GLU B  210  ALA B  218  1                                   9
HELIX   27 AC9 LYS B  234  ASN B  246  1                                  13
HELIX   28 AD1 ALA B  260  GLU B  265  1                                   6
HELIX   29 AD2 GLU B  265  ARG B  283  1                                  19
HELIX   30 AD3 SER C   46  ASN C   49  5                                   4
HELIX   31 AD4 TRP C   50  GLN C   55  1                                   6
HELIX   32 AD5 ARG C   58  HIS C   61  5                                   4
HELIX   33 AD6 ALA C   81  ASP C   86  1                                   6
HELIX   34 AD7 ASP C   86  HIS C  102  1                                  17
HELIX   35 AD8 LEU C  113  GLY C  126  1                                  14
HELIX   36 AD9 HIS C  150  MET C  157  1                                   8
HELIX   37 AE1 ASP C  161  LEU C  175  1                                  15
HELIX   38 AE2 ASP C  182  LEU C  195  1                                  14
HELIX   39 AE3 SER C  197  VAL C  204  1                                   8
HELIX   40 AE4 ARG C  205  MET C  207  5                                   3
HELIX   41 AE5 GLU C  210  ALA C  218  1                                   9
HELIX   42 AE6 LYS C  234  ASN C  246  1                                  13
HELIX   43 AE7 ALA C  260  GLU C  265  1                                   6
HELIX   44 AE8 GLU C  265  SER C  282  1                                  18
HELIX   45 AE9 SER D   46  ASN D   49  5                                   4
HELIX   46 AF1 TRP D   50  GLN D   55  1                                   6
HELIX   47 AF2 ARG D   58  HIS D   61  5                                   4
HELIX   48 AF3 ALA D   81  ASP D   86  1                                   6
HELIX   49 AF4 ASP D   86  HIS D  102  1                                  17
HELIX   50 AF5 LEU D  113  GLY D  126  1                                  14
HELIX   51 AF6 HIS D  150  MET D  157  1                                   8
HELIX   52 AF7 ASP D  161  LEU D  175  1                                  15
HELIX   53 AF8 ASP D  182  LEU D  195  1                                  14
HELIX   54 AF9 SER D  197  ARG D  205  1                                   9
HELIX   55 AG1 GLU D  210  ALA D  218  1                                   9
HELIX   56 AG2 LYS D  234  ASN D  246  1                                  13
HELIX   57 AG3 ALA D  260  GLU D  265  1                                   6
HELIX   58 AG4 GLU D  265  ARG D  283  1                                  19
SHEET    1 AA1 8 ARG A  12  THR A  17  0
SHEET    2 AA1 8 VAL A  23  GLY A  30 -1  O  LEU A  24   N  VAL A  16
SHEET    3 AA1 8 ARG A  63  TYR A  67 -1  O  THR A  66   N  GLN A  27
SHEET    4 AA1 8 PRO A  36  ILE A  40  1  N  ILE A  37   O  ILE A  65
SHEET    5 AA1 8 VAL A 107  TRP A 111  1  O  VAL A 109   N  ILE A  40
SHEET    6 AA1 8 GLY A 132  VAL A 136  1  O  VAL A 136   N  GLY A 110
SHEET    7 AA1 8 LEU A 222  GLY A 227  1  O  LEU A 225   N  TYR A 135
SHEET    8 AA1 8 ARG A 250  TYR A 254  1  O  TYR A 254   N  TYR A 226
SHEET    1 AA2 8 ASP B  13  THR B  17  0
SHEET    2 AA2 8 VAL B  23  GLY B  30 -1  O  LEU B  24   N  VAL B  16
SHEET    3 AA2 8 ARG B  63  TYR B  67 -1  O  THR B  66   N  GLN B  27
SHEET    4 AA2 8 PRO B  36  ILE B  40  1  N  ILE B  37   O  ILE B  65
SHEET    5 AA2 8 VAL B 107  TRP B 111  1  O  VAL B 109   N  ILE B  40
SHEET    6 AA2 8 GLY B 132  VAL B 136  1  O  VAL B 136   N  GLY B 110
SHEET    7 AA2 8 LEU B 222  GLY B 227  1  O  LEU B 225   N  TYR B 135
SHEET    8 AA2 8 ARG B 250  TYR B 254  1  O  TYR B 254   N  TYR B 226
SHEET    1 AA3 8 ARG C  12  THR C  17  0
SHEET    2 AA3 8 VAL C  23  GLY C  30 -1  O  LEU C  24   N  VAL C  16
SHEET    3 AA3 8 ARG C  63  TYR C  67 -1  O  THR C  66   N  GLN C  27
SHEET    4 AA3 8 PRO C  36  ILE C  40  1  N  ILE C  37   O  ILE C  65
SHEET    5 AA3 8 VAL C 107  TRP C 111  1  O  VAL C 109   N  ILE C  40
SHEET    6 AA3 8 GLY C 132  VAL C 136  1  O  VAL C 136   N  GLY C 110
SHEET    7 AA3 8 LEU C 222  GLY C 227  1  O  LEU C 223   N  TYR C 135
SHEET    8 AA3 8 ARG C 250  TYR C 254  1  O  TYR C 254   N  TYR C 226
SHEET    1 AA4 8 ASP D  13  THR D  17  0
SHEET    2 AA4 8 VAL D  23  GLY D  30 -1  O  LEU D  24   N  VAL D  16
SHEET    3 AA4 8 ARG D  63  TYR D  67 -1  O  THR D  66   N  GLN D  27
SHEET    4 AA4 8 PRO D  36  ILE D  40  1  N  ILE D  37   O  ILE D  65
SHEET    5 AA4 8 VAL D 107  TRP D 111  1  O  VAL D 109   N  ILE D  40
SHEET    6 AA4 8 GLY D 132  VAL D 136  1  O  VAL D 136   N  GLY D 110
SHEET    7 AA4 8 LEU D 222  GLY D 227  1  O  LEU D 225   N  TYR D 135
SHEET    8 AA4 8 ARG D 250  TYR D 254  1  O  TYR D 254   N  TYR D 226
SITE     1 AC1  6 SER A 187  HOH A 415  HOH A 438  HOH A 744
SITE     2 AC1  6 ARG D 170  ARG D 174
SITE     1 AC2  5 LEU A  48  SER A  51  LEU A 263  HOH A 662
SITE     2 AC2  5 HOH A 756
SITE     1 AC3  7 ALA A 228  ASP A 230  VAL A 233  LYS A 234
SITE     2 AC3  7 ALA A 235  HOH A 525  HOH A 617
SITE     1 AC4  6 GLU A 252  ARG A 268  ARG A 271  ASP A 272
SITE     2 AC4  6 HOH A 421  GLU D  99
SITE     1 AC5  6 HOH A 406  HOH A 411  ILE D  98  GLU D  99
SITE     2 AC5  6 TYR D 121  TYR D 125
SITE     1 AC6  6 ASP A 275  ARG A 278  HOH A 417  HOH A 428
SITE     2 AC6  6 PRO D  19  ASP D  20
SITE     1 AC7  5 LYS A  52  ARG A 179  PRO A 181  LEU A 263
SITE     2 AC7  5 HOH A 566
SITE     1 AC8  2 SER A 112  LEU A 232
SITE     1 AC9  8 ALA B 228  ASP B 230  VAL B 233  LYS B 234
SITE     2 AC9  8 ALA B 235  HOH B 508  HOH B 585  HOH B 591
SITE     1 AD1  5 LYS B  77  ALA B 194  LEU B 195  ALA B 196
SITE     2 AD1  5 LEU C 195
SITE     1 AD2  7 ILE B  98  GLU B  99  TYR B 121  TYR B 125
SITE     2 AD2  7 HOH B 404  ARG C 268  HOH C 415
SITE     1 AD3  1 SER C 187
SITE     1 AD4  7 ALA C 228  ASP C 230  VAL C 233  LYS C 234
SITE     2 AD4  7 ALA C 235  HOH C 517  HOH C 581
SITE     1 AD5  7 GLU B  99  GLU C 252  TYR C 254  ARG C 268
SITE     2 AD5  7 ARG C 271  ASP C 272  HOH C 404
SITE     1 AD6  5 HIS C 150  PRO C 151  GLU C 152  VAL C 153
SITE     2 AD6  5 HOH C 695
SITE     1 AD7  2 SER B 187  ARG C 174
SITE     1 AD8  6 LEU D  48  ASN D  49  SER D  51  LEU D 188
SITE     2 AD8  6 LEU D 263  HOH D 564
SITE     1 AD9  9 TYR A 254  ALA A 255  ASP A 256  GLU A 265
SITE     2 AD9  9 ARG A 268  ILE D  98  GLU D  99  HOH D 402
SITE     3 AD9  9 HOH D 441
SITE     1 AE1  3 SER D 112  TYR D 154  HOH D 600
SITE     1 AE2  1 SER D 187
CRYST1   65.720   80.370   99.400  90.00  93.07  90.00 P 1 21 1      8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.015216  0.000000  0.000815        0.00000
SCALE2      0.000000  0.012442  0.000000        0.00000
SCALE3      0.000000  0.000000  0.010075        0.00000
TER    2134      ARG A 283
TER    4257      ARG B 283
TER    6377      ARG C 283
TER    8489      ARG D 283
MASTER      508    0   20   58   32    0   36    6 9644    4   74   88
END