longtext: 4X7B-pdb

content
HEADER    HYDROLASE                               09-DEC-14   4X7B
TITLE     CRYSTAL STRUCTURE OF LIPASE FROM GEOBACILLUS STEAROTHERMOPHILUS T6
TITLE    2 METHANOL STABLE VARIANT H86Y/A269T
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: LIPASE;
COMPND   3 CHAIN: A;
COMPND   4 FRAGMENT: UNP RESIDUES 34-418;
COMPND   5 EC: 3.1.1.3;
COMPND   6 ENGINEERED: YES;
COMPND   7 MUTATION: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: GEOBACILLUS STEAROTHERMOPHILUS T6;
SOURCE   3 ORGANISM_TAXID: 646309;
SOURCE   4 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);
SOURCE   5 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE   6 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE   7 EXPRESSION_SYSTEM_PLASMID: PET9A
KEYWDS    HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    M.KANTEEV,A.DROR,S.GIHAZ,A.FISHMAN
REVDAT   1   10-JUN-15 4X7B    0
JRNL        AUTH   A.DROR,M.KANTEEV,I.KAGAN,S.GIHAZ,A.SHAHAR,A.FISHMAN
JRNL        TITL   STRUCTURAL INSIGHTS INTO METHANOL-STABLE VARIANTS OF LIPASE
JRNL        TITL 2 T6 FROM GEOBACILLUS STEAROTHERMOPHILUS.
JRNL        REF    APPL.MICROBIOL.BIOTECHNOL.                 2015
JRNL        REFN                   ESSN 1432-0614
JRNL        PMID   26026940
JRNL        DOI    10.1007/S00253-015-6700-4
REMARK   2
REMARK   2 RESOLUTION.    2.40 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : ML
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.40
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 30.27
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.340
REMARK   3   COMPLETENESS FOR RANGE        (%) : 96.8
REMARK   3   NUMBER OF REFLECTIONS             : 16078
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.206
REMARK   3   R VALUE            (WORKING SET) : 0.204
REMARK   3   FREE R VALUE                     : 0.248
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.040
REMARK   3   FREE R VALUE TEST SET COUNT      : 811
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 30.2745 -  4.3575    0.93     2598   128  0.1751 0.1906
REMARK   3     2  4.3575 -  3.4603    0.94     2513   120  0.1672 0.1998
REMARK   3     3  3.4603 -  3.0233    0.98     2556   138  0.2121 0.2615
REMARK   3     4  3.0233 -  2.7471    0.98     2543   142  0.2378 0.2823
REMARK   3     5  2.7471 -  2.5503    0.99     2526   154  0.2512 0.3158
REMARK   3     6  2.5503 -  2.4000    0.99     2531   129  0.2669 0.3513
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.20
REMARK   3   SHRINKAGE RADIUS   : 0.98
REMARK   3   K_SOL              : 0.35
REMARK   3   B_SOL              : 20.85
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.360
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 24.340
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 22.99
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 23.50
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -2.44110
REMARK   3    B22 (A**2) : -9.72660
REMARK   3    B33 (A**2) : 15.13750
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.005           3205
REMARK   3   ANGLE     :  0.723           4366
REMARK   3   CHIRALITY :  0.051            451
REMARK   3   PLANARITY :  0.003            570
REMARK   3   DIHEDRAL  : 11.109           1133
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 4X7B COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 09-DEC-14.
REMARK 100 THE DEPOSITION ID IS D_1000205205.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 07-APR-14
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : NULL
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : N
REMARK 200  RADIATION SOURCE               : ROTATING ANODE
REMARK 200  BEAMLINE                       : NULL
REMARK 200  X-RAY GENERATOR MODEL          : RIGAKU
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.56
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : IMAGE PLATE
REMARK 200  DETECTOR MANUFACTURER          : RIGAKU RAXIS
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : NULL
REMARK 200  DATA SCALING SOFTWARE          : SCALA 3.3.20
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 16204
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.400
REMARK 200  RESOLUTION RANGE LOW       (A) : 60.778
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 97.8
REMARK 200  DATA REDUNDANCY                : 3.000
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : 0.07500
REMARK 200   FOR THE DATA SET  : 10.0000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.40
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.53
REMARK 200  COMPLETENESS FOR SHELL     (%) : 99.8
REMARK 200  DATA REDUNDANCY IN SHELL       : 3.10
REMARK 200  R MERGE FOR SHELL          (I) : 0.17800
REMARK 200  R SYM FOR SHELL            (I) : 0.17800
REMARK 200   FOR SHELL         : 4.000
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER 2.3.0
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 47.15
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.33
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.2M SODIUM CITRATE, 25% PEG3350,
REMARK 280  VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 298K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X+1/2,-Y,Z+1/2
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       24.90500
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       57.18000
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       35.87500
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       57.18000
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       24.90500
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       35.87500
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 300 REMARK: BIOLOGICAL UNIT IS THE SAME AS ASYM.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 90 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 15560 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -12.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    SER A 114     -131.15     57.34
REMARK 500    HIS A 154       65.86   -116.68
REMARK 500    ASP A 176       40.85   -109.07
REMARK 500    LEU A 209       47.96    -95.26
REMARK 500    ARG A 272       43.71   -149.14
REMARK 500    ASP A 311     -163.13   -102.22
REMARK 500    LYS A 330      -45.77   -130.79
REMARK 500    ASP A 351       98.88    -68.94
REMARK 500    ASN A 368       89.58   -161.23
REMARK 500
REMARK 500 REMARK: NULL
REMARK 620
REMARK 620 METAL COORDINATION
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              ZN A 401  ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ASP A  62   OD1
REMARK 620 2 ASP A  62   OD2  63.0
REMARK 620 3 HIS A  82   NE2  89.4 152.3
REMARK 620 4 HIS A  88   NE2 112.6  95.3  98.3
REMARK 620 5 ASP A 239   OD1  98.0 101.4  78.5 149.3
REMARK 620 6 ASP A 239   OD2 144.7  89.8 114.0  90.7  63.9
REMARK 620 N                    1     2     3     4     5
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA A 402  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 GLY A 287   O
REMARK 620 2 GLU A 361   OE2  83.7
REMARK 620 3 ASP A 366   OD2 108.1 102.4
REMARK 620 4 PRO A 367   O   163.7 101.2  86.3
REMARK 620 N                    1     2     3
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN A 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CA A 402
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 4X6U   RELATED DB: PDB
DBREF  4X7B A    5   389  UNP    Q93A71   Q93A71_GEOSE    34    418
SEQADV 4X7B TYR A   86  UNP  Q93A71    HIS   115 ENGINEERED MUTATION
SEQADV 4X7B THR A  269  UNP  Q93A71    ALA   298 ENGINEERED MUTATION
SEQADV 4X7B ALA A  323  UNP  Q93A71    THR   352 CONFLICT
SEQADV 4X7B HIS A  390  UNP  Q93A71              EXPRESSION TAG
SEQADV 4X7B HIS A  391  UNP  Q93A71              EXPRESSION TAG
SEQADV 4X7B HIS A  392  UNP  Q93A71              EXPRESSION TAG
SEQADV 4X7B HIS A  393  UNP  Q93A71              EXPRESSION TAG
SEQADV 4X7B HIS A  394  UNP  Q93A71              EXPRESSION TAG
SEQADV 4X7B HIS A  395  UNP  Q93A71              EXPRESSION TAG
SEQRES   1 A  391  ARG ALA ASN ASP ALA PRO ILE VAL LEU LEU HIS GLY PHE
SEQRES   2 A  391  THR GLY TRP GLY ARG GLU GLU MET PHE GLY PHE LYS TYR
SEQRES   3 A  391  TRP GLY GLY VAL ARG GLY ASP ILE GLU GLN TRP LEU ASN
SEQRES   4 A  391  ASP ASN GLY TYR ARG THR TYR THR LEU ALA VAL GLY PRO
SEQRES   5 A  391  LEU SER SER ASN TRP ASP ARG ALA CYS GLU ALA TYR ALA
SEQRES   6 A  391  GLN LEU VAL GLY GLY THR VAL ASP TYR GLY ALA ALA HIS
SEQRES   7 A  391  ALA ALA LYS TYR GLY HIS ALA ARG PHE GLY ARG THR TYR
SEQRES   8 A  391  PRO GLY LEU LEU PRO GLU LEU LYS ARG GLY GLY ARG ILE
SEQRES   9 A  391  HIS ILE ILE ALA HIS SER GLN GLY GLY GLN THR ALA ARG
SEQRES  10 A  391  MET LEU VAL SER LEU LEU GLU ASN GLY SER GLN GLU GLU
SEQRES  11 A  391  ARG GLU TYR ALA LYS ALA HIS ASN VAL SER LEU SER PRO
SEQRES  12 A  391  LEU PHE GLU GLY GLY HIS HIS PHE VAL LEU SER VAL THR
SEQRES  13 A  391  THR ILE ALA THR PRO HIS ASP GLY THR THR LEU VAL ASN
SEQRES  14 A  391  MET VAL ASP PHE THR ASP ARG PHE PHE ASP LEU GLN LYS
SEQRES  15 A  391  ALA VAL LEU LYS ALA ALA ALA VAL ALA SER ASN VAL PRO
SEQRES  16 A  391  TYR THR SER GLN VAL TYR ASP PHE LYS LEU ASP GLN TRP
SEQRES  17 A  391  GLY LEU ARG ARG GLN PRO GLY GLU SER PHE ASP GLN TYR
SEQRES  18 A  391  PHE GLU ARG LEU LYS ARG SER PRO VAL TRP THR SER THR
SEQRES  19 A  391  ASP THR ALA ARG TYR ASP LEU SER VAL PRO GLY ALA GLU
SEQRES  20 A  391  LYS LEU ASN GLN TRP VAL LYS ALA SER PRO ASN THR TYR
SEQRES  21 A  391  TYR LEU SER PHE THR THR GLU ARG THR TYR ARG GLY ALA
SEQRES  22 A  391  LEU THR GLY ASN TYR TYR PRO GLU LEU GLY MET ASN ALA
SEQRES  23 A  391  PHE SER ALA VAL VAL CYS ALA PRO PHE LEU GLY SER TYR
SEQRES  24 A  391  ARG ASN ALA THR LEU GLY ILE ASP ASP ARG TRP LEU GLU
SEQRES  25 A  391  ASN ASP GLY ILE VAL ASN ALA PHE SER MET ASN GLY PRO
SEQRES  26 A  391  LYS ARG GLY SER THR ASP ARG ILE VAL PRO TYR ASP GLY
SEQRES  27 A  391  THR ILE LYS LYS GLY VAL TRP ASN ASP MET GLY THR TYR
SEQRES  28 A  391  ASN VAL ASP HIS LEU GLU VAL ILE GLY VAL ASP PRO ASN
SEQRES  29 A  391  PRO LEU PHE ASP ILE ARG ALA PHE TYR LEU ARG LEU ALA
SEQRES  30 A  391  GLU GLN LEU ALA SER LEU GLN PRO HIS HIS HIS HIS HIS
SEQRES  31 A  391  HIS
HET     ZN  A 401       1
HET     CA  A 402       1
HETNAM      ZN ZINC ION
HETNAM      CA CALCIUM ION
FORMUL   2   ZN    ZN 2+
FORMUL   3   CA    CA 2+
FORMUL   4  HOH   *176(H2 O)
HELIX    1 AA1 GLU A   24  PHE A   28  5                                   5
HELIX    2 AA2 ASP A   37  ASN A   45  1                                   9
HELIX    3 AA3 SER A   59  GLY A   73  1                                  15
HELIX    4 AA4 GLY A   79  GLY A   87  1                                   9
HELIX    5 AA5 LEU A   99  LYS A  103  5                                   5
HELIX    6 AA6 GLN A  115  GLY A  130  1                                  16
HELIX    7 AA7 SER A  131  ASN A  142  1                                  12
HELIX    8 AA8 SER A  146  GLU A  150  5                                   5
HELIX    9 AA9 THR A  169  MET A  174  5                                   6
HELIX   10 AB1 ASP A  176  ALA A  192  1                                  17
HELIX   11 AB2 SER A  221  ARG A  231  1                                  11
HELIX   12 AB3 SER A  232  SER A  237  1                                   6
HELIX   13 AB4 THR A  240  SER A  246  1                                   7
HELIX   14 AB5 SER A  246  GLN A  255  1                                  10
HELIX   15 AB6 ASN A  289  VAL A  295  1                                   7
HELIX   16 AB7 CYS A  296  GLY A  301  1                                   6
HELIX   17 AB8 ASN A  322  MET A  326  5                                   5
HELIX   18 AB9 ASP A  372  SER A  386  1                                  15
SHEET    1 AA1 7 THR A  49  LEU A  52  0
SHEET    2 AA1 7 ILE A  11  LEU A  14  1  N  ILE A  11   O  TYR A  50
SHEET    3 AA1 7 ILE A 108  HIS A 113  1  O  HIS A 109   N  VAL A  12
SHEET    4 AA1 7 VAL A 156  ILE A 162  1  O  THR A 160   N  ALA A 112
SHEET    5 AA1 7 TYR A 264  THR A 270  1  O  LEU A 266   N  THR A 161
SHEET    6 AA1 7 TRP A 349  TYR A 355  1  O  TYR A 355   N  THR A 269
SHEET    7 AA1 7 ILE A 337  PRO A 339  1  N  VAL A 338   O  ASP A 351
SHEET    1 AA2 2 GLY A  74  ASP A  77  0
SHEET    2 AA2 2 PHE A  91  TYR A  95 -1  O  ARG A  93   N  VAL A  76
SHEET    1 AA3 2 THR A 273  ARG A 275  0
SHEET    2 AA3 2 TYR A 282  PRO A 284 -1  O  TYR A 283   N  TYR A 274
LINK         OD1 ASP A  62                ZN    ZN A 401     1555   1555  2.04
LINK         OD2 ASP A  62                ZN    ZN A 401     1555   1555  2.09
LINK         NE2 HIS A  82                ZN    ZN A 401     1555   1555  2.04
LINK         NE2 HIS A  88                ZN    ZN A 401     1555   1555  2.10
LINK         OD1 ASP A 239                ZN    ZN A 401     1555   1555  2.12
LINK         OD2 ASP A 239                ZN    ZN A 401     1555   1555  1.99
LINK         O   GLY A 287                CA    CA A 402     1555   1555  2.39
LINK         OE2 GLU A 361                CA    CA A 402     1555   1555  2.35
LINK         OD2 ASP A 366                CA    CA A 402     1555   1555  2.38
LINK         O   PRO A 367                CA    CA A 402     1555   1555  2.35
SITE     1 AC1  4 ASP A  62  HIS A  82  HIS A  88  ASP A 239
SITE     1 AC2  4 GLY A 287  GLU A 361  ASP A 366  PRO A 367
CRYST1   49.810   71.750  114.360  90.00  90.00  90.00 P 21 21 21    4
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.020076  0.000000  0.000000        0.00000
SCALE2      0.000000  0.013937  0.000000        0.00000
SCALE3      0.000000  0.000000  0.008744        0.00000
TER    3106      HIS A 395
MASTER      260    0    2   18   11    0    2    6 3283    1   13   31
END