longtext: 4ivj-pdb

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HEADER    OXIDOREDUCTASE                          23-JAN-13   4IVJ
TITLE     STRUCTURE OF A 16 NM PROTEIN CAGE DESIGNED BY FUSING SYMMETRIC
TITLE    2 OLIGOMERIC DOMAINS, TRIPLE MUTANT, I222 FORM
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: NON-HAEM BROMOPEROXIDASE BPO-A2, MATRIX PROTEIN 1;
COMPND   3 CHAIN: A, B, C;
COMPND   4 SYNONYM: BPO2, BROMIDE PEROXIDASE, M1;
COMPND   5 EC: 1.11.1.-;
COMPND   6 ENGINEERED: YES;
COMPND   7 MUTATION: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: STREPTOMYCES AUREOFACIENS, INFLUENZA A VIRUS;
SOURCE   3 ORGANISM_TAXID: 1894, 211044;
SOURCE   4 STRAIN: A/PUERTO RICO/8/1934 H1N1;
SOURCE   5 GENE: BPOA2, BROMOPEROXIDASE A2 AND M1 MATRIX, M;
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PET22B
KEYWDS    PROTEIN DESIGN, BIONANOTECHNOLOGY, PROTEIN ASSEMBLY, SYMMETRIC
KEYWDS   2 OLIGOMERIC DOMAINS, BIOMATERIALS, OXIDOREDUCTASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    Y.-T.LAI,M.R.SAWAYA,T.O.YEATES
REVDAT   1   24-JUL-13 4IVJ    0
JRNL        AUTH   Y.T.LAI,K.L.TSAI,M.R.SAWAYA,F.J.ASTURIAS,T.O.YEATES
JRNL        TITL   STRUCTURE AND FLEXIBILITY OF NANOSCALE PROTEIN CAGES
JRNL        TITL 2 DESIGNED BY SYMMETRIC SELF-ASSEMBLY.
JRNL        REF    J.AM.CHEM.SOC.                V. 135  7738 2013
JRNL        REFN                   ISSN 0002-7863
JRNL        PMID   23621606
JRNL        DOI    10.1021/JA402277F
REMARK   2
REMARK   2 RESOLUTION.    7.35 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX (PHENIX.REFINE: 1.8.1_1168)
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VICENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-
REMARK   3               : KUNSTLEVE,LI-WEI HUNG,ROBERT IMMORMINO,
REMARK   3               : TOM IOERGER,AIRLIE MCCOY,ERIK MCKEE,NIGEL
REMARK   3               : MORIARTY,REETAL PAI,RANDY READ,JANE
REMARK   3               : RICHARDSON,DAVID RICHARDSON,TOD ROMO,JIM
REMARK   3               : SACCHETTINI,NICHOLAS SAUTER,JACOB SMITH,
REMARK   3               : LAURENT STORONI,TOM TERWILLIGER,PETER
REMARK   3               : ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : ML
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 7.35
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 28.42
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.990
REMARK   3   COMPLETENESS FOR RANGE        (%) : 97.0
REMARK   3   NUMBER OF REFLECTIONS             : 2431
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.277
REMARK   3   R VALUE            (WORKING SET) : 0.276
REMARK   3   FREE R VALUE                     : 0.288
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.980
REMARK   3   FREE R VALUE TEST SET COUNT      : 121
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1  0.0000 -  0.0000    0.00        0     0  0.0000 0.0000
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.390
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 31.130
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 383.65
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 318.45
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.015          10425
REMARK   3   ANGLE     :  2.390          14187
REMARK   3   CHIRALITY :  0.114           1602
REMARK   3   PLANARITY :  0.008           1848
REMARK   3   DIHEDRAL  : 15.896           3702
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 6
REMARK   3   TLS GROUP : 1
REMARK   3    SELECTION: chain A and resid 1:287
REMARK   3    ORIGIN FOR THE GROUP (A): -21.4924  -9.9458 -46.5575
REMARK   3    T TENSOR
REMARK   3      T11:   3.0482 T22:   3.2616
REMARK   3      T33:   1.5458 T12:   0.9584
REMARK   3      T13:  -0.1520 T23:   0.1838
REMARK   3    L TENSOR
REMARK   3      L11:  -0.1127 L22:   2.6937
REMARK   3      L33:   1.7775 L12:  -1.0663
REMARK   3      L13:  -0.8059 L23:  -0.1502
REMARK   3    S TENSOR
REMARK   3      S11:   1.2449 S12:   1.2203 S13:   0.4773
REMARK   3      S21:  -3.2035 S22:  -0.7876 S23:  -0.2934
REMARK   3      S31:   0.2291 S32:  -0.2024 S33:   0.9941
REMARK   3   TLS GROUP : 2
REMARK   3    SELECTION: chain A and resid 288:440
REMARK   3    ORIGIN FOR THE GROUP (A): -18.4564  10.4953  -9.5139
REMARK   3    T TENSOR
REMARK   3      T11:   2.0737 T22:   2.7266
REMARK   3      T33:   1.6132 T12:  -0.1233
REMARK   3      T13:  -0.2610 T23:   0.4405
REMARK   3    L TENSOR
REMARK   3      L11:   0.1544 L22:   1.4581
REMARK   3      L33:   4.5457 L12:  -0.3267
REMARK   3      L13:  -1.2570 L23:   0.0635
REMARK   3    S TENSOR
REMARK   3      S11:  -0.7126 S12:   0.8972 S13:   0.9198
REMARK   3      S21:   0.0237 S22:   1.1725 S23:   0.7249
REMARK   3      S31:   1.7696 S32:  -3.0428 S33:  -1.4010
REMARK   3   TLS GROUP : 3
REMARK   3    SELECTION: chain B and resid 1:287
REMARK   3    ORIGIN FOR THE GROUP (A): -43.2757 -41.3402 -45.6845
REMARK   3    T TENSOR
REMARK   3      T11:   4.9966 T22:   3.4023
REMARK   3      T33:   5.7894 T12:  -1.4471
REMARK   3      T13:  -3.3650 T23:   0.3835
REMARK   3    L TENSOR
REMARK   3      L11:   0.3655 L22:   0.3294
REMARK   3      L33:   1.4732 L12:   0.4809
REMARK   3      L13:   0.9107 L23:   0.9790
REMARK   3    S TENSOR
REMARK   3      S11:   0.4068 S12:   0.6485 S13:  -0.9438
REMARK   3      S21:  -4.3219 S22:   3.0816 S23:   2.7255
REMARK   3      S31:   3.3496 S32:  -4.4964 S33:   4.9831
REMARK   3   TLS GROUP : 4
REMARK   3    SELECTION: chain B and resid 288:440
REMARK   3    ORIGIN FOR THE GROUP (A): -70.7310 -12.6252 -59.4230
REMARK   3    T TENSOR
REMARK   3      T11:   4.3621 T22:   3.1773
REMARK   3      T33:   5.1499 T12:  -1.0683
REMARK   3      T13:  -0.9445 T23:   0.2081
REMARK   3    L TENSOR
REMARK   3      L11:   2.5681 L22:   3.3008
REMARK   3      L33:   2.6542 L12:  -0.9439
REMARK   3      L13:   2.1541 L23:  -1.2848
REMARK   3    S TENSOR
REMARK   3      S11:   1.1276 S12:  -0.7317 S13:  -2.1472
REMARK   3      S21:   0.2036 S22:   2.3021 S23:   3.0470
REMARK   3      S31:  -0.5486 S32:  -1.6189 S33:   1.3616
REMARK   3   TLS GROUP : 5
REMARK   3    SELECTION: chain C and resid 1:287
REMARK   3    ORIGIN FOR THE GROUP (A): -20.4393 -33.5752 -16.6105
REMARK   3    T TENSOR
REMARK   3      T11:   1.6115 T22:   2.1174
REMARK   3      T33:   1.1633 T12:   0.4662
REMARK   3      T13:   0.3324 T23:  -1.2729
REMARK   3    L TENSOR
REMARK   3      L11:   3.1097 L22:   2.4024
REMARK   3      L33:   5.5959 L12:  -1.0853
REMARK   3      L13:   2.7488 L23:  -1.2347
REMARK   3    S TENSOR
REMARK   3      S11:   0.7753 S12:   1.1553 S13:  -1.7417
REMARK   3      S21:  -0.1346 S22:   1.7366 S23:   2.0356
REMARK   3      S31:   1.1200 S32:   1.4808 S33:   8.1279
REMARK   3   TLS GROUP : 6
REMARK   3    SELECTION: chain C and resid 288:440
REMARK   3    ORIGIN FOR THE GROUP (A): -53.1720 -43.7673   8.3307
REMARK   3    T TENSOR
REMARK   3      T11:   2.3891 T22:   3.0602
REMARK   3      T33:   2.8469 T12:   0.1185
REMARK   3      T13:   1.5078 T23:   0.5015
REMARK   3    L TENSOR
REMARK   3      L11:   2.6100 L22:   2.3415
REMARK   3      L33:   4.0401 L12:   0.3953
REMARK   3      L13:   1.5009 L23:   2.9856
REMARK   3    S TENSOR
REMARK   3      S11:   1.9225 S12:  -1.3373 S13:  -1.1489
REMARK   3      S21:   1.3102 S22:   0.7601 S23:  -0.8581
REMARK   3      S31:   0.0706 S32:   1.1985 S33:   3.4062
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 4IVJ COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 24-JAN-13.
REMARK 100 THE RCSB ID CODE IS RCSB077262.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 29-AUG-12
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 4.4
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : N
REMARK 200  RADIATION SOURCE               : ROTATING ANODE
REMARK 200  BEAMLINE                       : NULL
REMARK 200  X-RAY GENERATOR MODEL          : RIGAKU
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.542
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : IMAGE PLATE
REMARK 200  DETECTOR MANUFACTURER          : RIGAKU RAXIS HTC
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : XSCALE
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 2438
REMARK 200  RESOLUTION RANGE HIGH      (A) : 7.350
REMARK 200  RESOLUTION RANGE LOW       (A) : 29.283
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : -3.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 95.2
REMARK 200  DATA REDUNDANCY                : NULL
REMARK 200  R MERGE                    (I) : 0.08200
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 13.2400
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 7.35
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 7.54
REMARK 200  COMPLETENESS FOR SHELL     (%) : 96.7
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : 0.77800
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 1.440
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: 1BRO AND 1AA7
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 57.58
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.90
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1M NA CITRATE PH 4.4, 10% PEG 3000,
REMARK 280  VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 298K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: I 2 2 2
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,-Y,Z
REMARK 290       3555   -X,Y,-Z
REMARK 290       4555   X,-Y,-Z
REMARK 290       5555   X+1/2,Y+1/2,Z+1/2
REMARK 290       6555   -X+1/2,-Y+1/2,Z+1/2
REMARK 290       7555   -X+1/2,Y+1/2,-Z+1/2
REMARK 290       8555   X+1/2,-Y+1/2,-Z+1/2
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   5  1.000000  0.000000  0.000000       64.83500
REMARK 290   SMTRY2   5  0.000000  1.000000  0.000000       80.49000
REMARK 290   SMTRY3   5  0.000000  0.000000  1.000000       83.81500
REMARK 290   SMTRY1   6 -1.000000  0.000000  0.000000       64.83500
REMARK 290   SMTRY2   6  0.000000 -1.000000  0.000000       80.49000
REMARK 290   SMTRY3   6  0.000000  0.000000  1.000000       83.81500
REMARK 290   SMTRY1   7 -1.000000  0.000000  0.000000       64.83500
REMARK 290   SMTRY2   7  0.000000  1.000000  0.000000       80.49000
REMARK 290   SMTRY3   7  0.000000  0.000000 -1.000000       83.81500
REMARK 290   SMTRY1   8  1.000000  0.000000  0.000000       64.83500
REMARK 290   SMTRY2   8  0.000000 -1.000000  0.000000       80.49000
REMARK 290   SMTRY3   8  0.000000  0.000000 -1.000000       83.81500
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DODECAMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DODECAMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 34510 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 188550 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -112.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350   BIOMT1   2 -1.000000  0.000000  0.000000     -129.67000
REMARK 350   BIOMT2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 350   BIOMT3   2  0.000000  0.000000  1.000000        0.00000
REMARK 350   BIOMT1   3 -1.000000  0.000000  0.000000     -129.67000
REMARK 350   BIOMT2   3  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   3  0.000000  0.000000 -1.000000        0.00000
REMARK 350   BIOMT1   4  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   4  0.000000 -1.000000  0.000000        0.00000
REMARK 350   BIOMT3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A     0
REMARK 465     GLN A   441
REMARK 465     HIS A   442
REMARK 465     ARG A   443
REMARK 465     SER A   444
REMARK 465     HIS A   445
REMARK 465     ARG A   446
REMARK 465     GLN A   447
REMARK 465     LEU A   448
REMARK 465     GLU A   449
REMARK 465     HIS A   450
REMARK 465     HIS A   451
REMARK 465     HIS A   452
REMARK 465     HIS A   453
REMARK 465     HIS A   454
REMARK 465     HIS A   455
REMARK 465     MET B     0
REMARK 465     GLN B   441
REMARK 465     HIS B   442
REMARK 465     ARG B   443
REMARK 465     SER B   444
REMARK 465     HIS B   445
REMARK 465     ARG B   446
REMARK 465     GLN B   447
REMARK 465     LEU B   448
REMARK 465     GLU B   449
REMARK 465     HIS B   450
REMARK 465     HIS B   451
REMARK 465     HIS B   452
REMARK 465     HIS B   453
REMARK 465     HIS B   454
REMARK 465     HIS B   455
REMARK 465     MET C     0
REMARK 465     GLN C   441
REMARK 465     HIS C   442
REMARK 465     ARG C   443
REMARK 465     SER C   444
REMARK 465     HIS C   445
REMARK 465     ARG C   446
REMARK 465     GLN C   447
REMARK 465     LEU C   448
REMARK 465     GLU C   449
REMARK 465     HIS C   450
REMARK 465     HIS C   451
REMARK 465     HIS C   452
REMARK 465     HIS C   453
REMARK 465     HIS C   454
REMARK 465     HIS C   455
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ASN A   9     -131.49     55.95
REMARK 500    PRO A  33       49.50   -105.62
REMARK 500    GLN A  66       65.22   -119.44
REMARK 500    SER A  98     -117.94     51.09
REMARK 500    THR A 176      -82.60   -116.14
REMARK 500    TYR A 206       35.22    -90.43
REMARK 500    PRO A 256     -168.99    -79.78
REMARK 500    ASN B   9     -124.25     54.60
REMARK 500    PRO B  33       49.51   -105.76
REMARK 500    ARG B  59      135.55    -38.38
REMARK 500    GLN B  66       65.18   -119.25
REMARK 500    SER B  98     -127.10     58.30
REMARK 500    THR B 176      -78.74   -125.34
REMARK 500    PRO B 256     -169.03    -79.71
REMARK 500    ASN C   9     -124.13     54.51
REMARK 500    PRO C  33       49.36   -105.88
REMARK 500    GLN C  66       65.20   -119.51
REMARK 500    SER C  98     -117.92     51.13
REMARK 500    THR C 176      -88.23   -118.52
REMARK 500    TYR C 206       35.42    -90.46
REMARK 500    PRO C 219      135.75    -38.86
REMARK 500    PRO C 256     -168.98    -79.82
REMARK 500
REMARK 500 REMARK: NULL
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 3VDX   RELATED DB: PDB
REMARK 900 RELATED ID: 4D9J   RELATED DB: PDB
REMARK 900 RELATED ID: 4IQ4   RELATED DB: PDB
REMARK 900 RELATED ID: 4ITV   RELATED DB: PDB
DBREF  4IVJ A    0   277  UNP    P29715   BPOA2_STRAU      1    278
DBREF  4IVJ A  286   448  UNP    P03485   M1_I34A1         3    165
DBREF  4IVJ B    0   277  UNP    P29715   BPOA2_STRAU      1    278
DBREF  4IVJ B  286   448  UNP    P03485   M1_I34A1         3    165
DBREF  4IVJ C    0   277  UNP    P29715   BPOA2_STRAU      1    278
DBREF  4IVJ C  286   448  UNP    P03485   M1_I34A1         3    165
SEQADV 4IVJ THR A   24  UNP  P29715    GLN    25 ENGINEERED MUTATION
SEQADV 4IVJ ALA A  118  UNP  P29715    LYS   119 ENGINEERED MUTATION
SEQADV 4IVJ ALA A  278  UNP  P03485              LINKER
SEQADV 4IVJ GLN A  279  UNP  P03485              LINKER
SEQADV 4IVJ GLU A  280  UNP  P03485              LINKER
SEQADV 4IVJ ALA A  281  UNP  P03485              LINKER
SEQADV 4IVJ GLN A  282  UNP  P03485              LINKER
SEQADV 4IVJ LYS A  283  UNP  P03485              LINKER
SEQADV 4IVJ GLN A  284  UNP  P03485              LINKER
SEQADV 4IVJ LYS A  285  UNP  P03485              LINKER
SEQADV 4IVJ LEU A  448  UNP  P03485              EXPRESSION TAG
SEQADV 4IVJ GLU A  449  UNP  P03485              EXPRESSION TAG
SEQADV 4IVJ HIS A  450  UNP  P03485              EXPRESSION TAG
SEQADV 4IVJ HIS A  451  UNP  P03485              EXPRESSION TAG
SEQADV 4IVJ HIS A  452  UNP  P03485              EXPRESSION TAG
SEQADV 4IVJ HIS A  453  UNP  P03485              EXPRESSION TAG
SEQADV 4IVJ HIS A  454  UNP  P03485              EXPRESSION TAG
SEQADV 4IVJ HIS A  455  UNP  P03485              EXPRESSION TAG
SEQADV 4IVJ THR B   24  UNP  P29715    GLN    25 ENGINEERED MUTATION
SEQADV 4IVJ ALA B  118  UNP  P29715    LYS   119 ENGINEERED MUTATION
SEQADV 4IVJ ALA B  278  UNP  P03485              LINKER
SEQADV 4IVJ GLN B  279  UNP  P03485              LINKER
SEQADV 4IVJ GLU B  280  UNP  P03485              LINKER
SEQADV 4IVJ ALA B  281  UNP  P03485              LINKER
SEQADV 4IVJ GLN B  282  UNP  P03485              LINKER
SEQADV 4IVJ LYS B  283  UNP  P03485              LINKER
SEQADV 4IVJ GLN B  284  UNP  P03485              LINKER
SEQADV 4IVJ LYS B  285  UNP  P03485              LINKER
SEQADV 4IVJ LEU B  448  UNP  P03485              EXPRESSION TAG
SEQADV 4IVJ GLU B  449  UNP  P03485              EXPRESSION TAG
SEQADV 4IVJ HIS B  450  UNP  P03485              EXPRESSION TAG
SEQADV 4IVJ HIS B  451  UNP  P03485              EXPRESSION TAG
SEQADV 4IVJ HIS B  452  UNP  P03485              EXPRESSION TAG
SEQADV 4IVJ HIS B  453  UNP  P03485              EXPRESSION TAG
SEQADV 4IVJ HIS B  454  UNP  P03485              EXPRESSION TAG
SEQADV 4IVJ HIS B  455  UNP  P03485              EXPRESSION TAG
SEQADV 4IVJ THR C   24  UNP  P29715    GLN    25 ENGINEERED MUTATION
SEQADV 4IVJ ALA C  118  UNP  P29715    LYS   119 ENGINEERED MUTATION
SEQADV 4IVJ ALA C  278  UNP  P03485              LINKER
SEQADV 4IVJ GLN C  279  UNP  P03485              LINKER
SEQADV 4IVJ GLU C  280  UNP  P03485              LINKER
SEQADV 4IVJ ALA C  281  UNP  P03485              LINKER
SEQADV 4IVJ GLN C  282  UNP  P03485              LINKER
SEQADV 4IVJ LYS C  283  UNP  P03485              LINKER
SEQADV 4IVJ GLN C  284  UNP  P03485              LINKER
SEQADV 4IVJ LYS C  285  UNP  P03485              LINKER
SEQADV 4IVJ LEU C  448  UNP  P03485              EXPRESSION TAG
SEQADV 4IVJ GLU C  449  UNP  P03485              EXPRESSION TAG
SEQADV 4IVJ HIS C  450  UNP  P03485              EXPRESSION TAG
SEQADV 4IVJ HIS C  451  UNP  P03485              EXPRESSION TAG
SEQADV 4IVJ HIS C  452  UNP  P03485              EXPRESSION TAG
SEQADV 4IVJ HIS C  453  UNP  P03485              EXPRESSION TAG
SEQADV 4IVJ HIS C  454  UNP  P03485              EXPRESSION TAG
SEQADV 4IVJ HIS C  455  UNP  P03485              EXPRESSION TAG
SEQRES   1 A  456  MET PRO PHE ILE THR VAL GLY GLN GLU ASN SER THR SER
SEQRES   2 A  456  ILE ASP LEU TYR TYR GLU ASP HIS GLY THR GLY THR PRO
SEQRES   3 A  456  VAL VAL LEU ILE HIS GLY PHE PRO LEU SER GLY HIS SER
SEQRES   4 A  456  TRP GLU ARG GLN SER ALA ALA LEU LEU ASP ALA GLY TYR
SEQRES   5 A  456  ARG VAL ILE THR TYR ASP ARG ARG GLY PHE GLY GLN SER
SEQRES   6 A  456  SER GLN PRO THR THR GLY TYR ASP TYR ASP THR PHE ALA
SEQRES   7 A  456  ALA ASP LEU ASN THR VAL LEU GLU THR LEU ASP LEU GLN
SEQRES   8 A  456  ASP ALA VAL LEU VAL GLY PHE SER MET GLY THR GLY GLU
SEQRES   9 A  456  VAL ALA ARG TYR VAL SER SER TYR GLY THR ALA ARG ILE
SEQRES  10 A  456  ALA ALA VAL ALA PHE LEU ALA SER LEU GLU PRO PHE LEU
SEQRES  11 A  456  LEU LYS THR ASP ASP ASN PRO ASP GLY ALA ALA PRO GLN
SEQRES  12 A  456  GLU PHE PHE ASP GLY ILE VAL ALA ALA VAL LYS ALA ASP
SEQRES  13 A  456  ARG TYR ALA PHE TYR THR GLY PHE PHE ASN ASP PHE TYR
SEQRES  14 A  456  ASN LEU ASP GLU ASN LEU GLY THR ARG ILE SER GLU GLU
SEQRES  15 A  456  ALA VAL ARG ASN SER TRP ASN THR ALA ALA SER GLY GLY
SEQRES  16 A  456  PHE PHE ALA ALA ALA ALA ALA PRO THR THR TRP TYR THR
SEQRES  17 A  456  ASP PHE ARG ALA ASP ILE PRO ARG ILE ASP VAL PRO ALA
SEQRES  18 A  456  LEU ILE LEU HIS GLY THR GLY ASP ARG THR LEU PRO ILE
SEQRES  19 A  456  GLU ASN THR ALA ARG VAL PHE HIS LYS ALA LEU PRO SER
SEQRES  20 A  456  ALA GLU TYR VAL GLU VAL GLU GLY ALA PRO HIS GLY LEU
SEQRES  21 A  456  LEU TRP THR HIS ALA GLU GLU VAL ASN THR ALA LEU LEU
SEQRES  22 A  456  ALA PHE LEU ALA LYS ALA GLN GLU ALA GLN LYS GLN LYS
SEQRES  23 A  456  LEU LEU THR GLU VAL GLU THR TYR VAL LEU SER ILE ILE
SEQRES  24 A  456  PRO SER GLY PRO LEU LYS ALA GLU ILE ALA GLN ARG LEU
SEQRES  25 A  456  GLU ASP VAL PHE ALA GLY LYS ASN THR ASP LEU GLU VAL
SEQRES  26 A  456  LEU MET GLU TRP LEU LYS THR ARG PRO ILE LEU SER PRO
SEQRES  27 A  456  LEU THR LYS GLY ILE LEU GLY PHE VAL PHE THR LEU THR
SEQRES  28 A  456  VAL PRO SER GLU ARG GLY LEU GLN ARG ARG ARG PHE VAL
SEQRES  29 A  456  GLN ASN ALA LEU ASN GLY ASN GLY ASP PRO ASN ASN MET
SEQRES  30 A  456  ASP LYS ALA VAL LYS LEU TYR ARG LYS LEU LYS ARG GLU
SEQRES  31 A  456  ILE THR PHE HIS GLY ALA LYS GLU ILE SER LEU SER TYR
SEQRES  32 A  456  SER ALA GLY ALA LEU ALA SER CYS MET GLY LEU ILE TYR
SEQRES  33 A  456  ASN ARG MET GLY ALA VAL THR THR GLU VAL ALA PHE GLY
SEQRES  34 A  456  LEU VAL CYS ALA THR CYS GLU GLN ILE ALA ASP SER GLN
SEQRES  35 A  456  HIS ARG SER HIS ARG GLN LEU GLU HIS HIS HIS HIS HIS
SEQRES  36 A  456  HIS
SEQRES   1 B  456  MET PRO PHE ILE THR VAL GLY GLN GLU ASN SER THR SER
SEQRES   2 B  456  ILE ASP LEU TYR TYR GLU ASP HIS GLY THR GLY THR PRO
SEQRES   3 B  456  VAL VAL LEU ILE HIS GLY PHE PRO LEU SER GLY HIS SER
SEQRES   4 B  456  TRP GLU ARG GLN SER ALA ALA LEU LEU ASP ALA GLY TYR
SEQRES   5 B  456  ARG VAL ILE THR TYR ASP ARG ARG GLY PHE GLY GLN SER
SEQRES   6 B  456  SER GLN PRO THR THR GLY TYR ASP TYR ASP THR PHE ALA
SEQRES   7 B  456  ALA ASP LEU ASN THR VAL LEU GLU THR LEU ASP LEU GLN
SEQRES   8 B  456  ASP ALA VAL LEU VAL GLY PHE SER MET GLY THR GLY GLU
SEQRES   9 B  456  VAL ALA ARG TYR VAL SER SER TYR GLY THR ALA ARG ILE
SEQRES  10 B  456  ALA ALA VAL ALA PHE LEU ALA SER LEU GLU PRO PHE LEU
SEQRES  11 B  456  LEU LYS THR ASP ASP ASN PRO ASP GLY ALA ALA PRO GLN
SEQRES  12 B  456  GLU PHE PHE ASP GLY ILE VAL ALA ALA VAL LYS ALA ASP
SEQRES  13 B  456  ARG TYR ALA PHE TYR THR GLY PHE PHE ASN ASP PHE TYR
SEQRES  14 B  456  ASN LEU ASP GLU ASN LEU GLY THR ARG ILE SER GLU GLU
SEQRES  15 B  456  ALA VAL ARG ASN SER TRP ASN THR ALA ALA SER GLY GLY
SEQRES  16 B  456  PHE PHE ALA ALA ALA ALA ALA PRO THR THR TRP TYR THR
SEQRES  17 B  456  ASP PHE ARG ALA ASP ILE PRO ARG ILE ASP VAL PRO ALA
SEQRES  18 B  456  LEU ILE LEU HIS GLY THR GLY ASP ARG THR LEU PRO ILE
SEQRES  19 B  456  GLU ASN THR ALA ARG VAL PHE HIS LYS ALA LEU PRO SER
SEQRES  20 B  456  ALA GLU TYR VAL GLU VAL GLU GLY ALA PRO HIS GLY LEU
SEQRES  21 B  456  LEU TRP THR HIS ALA GLU GLU VAL ASN THR ALA LEU LEU
SEQRES  22 B  456  ALA PHE LEU ALA LYS ALA GLN GLU ALA GLN LYS GLN LYS
SEQRES  23 B  456  LEU LEU THR GLU VAL GLU THR TYR VAL LEU SER ILE ILE
SEQRES  24 B  456  PRO SER GLY PRO LEU LYS ALA GLU ILE ALA GLN ARG LEU
SEQRES  25 B  456  GLU ASP VAL PHE ALA GLY LYS ASN THR ASP LEU GLU VAL
SEQRES  26 B  456  LEU MET GLU TRP LEU LYS THR ARG PRO ILE LEU SER PRO
SEQRES  27 B  456  LEU THR LYS GLY ILE LEU GLY PHE VAL PHE THR LEU THR
SEQRES  28 B  456  VAL PRO SER GLU ARG GLY LEU GLN ARG ARG ARG PHE VAL
SEQRES  29 B  456  GLN ASN ALA LEU ASN GLY ASN GLY ASP PRO ASN ASN MET
SEQRES  30 B  456  ASP LYS ALA VAL LYS LEU TYR ARG LYS LEU LYS ARG GLU
SEQRES  31 B  456  ILE THR PHE HIS GLY ALA LYS GLU ILE SER LEU SER TYR
SEQRES  32 B  456  SER ALA GLY ALA LEU ALA SER CYS MET GLY LEU ILE TYR
SEQRES  33 B  456  ASN ARG MET GLY ALA VAL THR THR GLU VAL ALA PHE GLY
SEQRES  34 B  456  LEU VAL CYS ALA THR CYS GLU GLN ILE ALA ASP SER GLN
SEQRES  35 B  456  HIS ARG SER HIS ARG GLN LEU GLU HIS HIS HIS HIS HIS
SEQRES  36 B  456  HIS
SEQRES   1 C  456  MET PRO PHE ILE THR VAL GLY GLN GLU ASN SER THR SER
SEQRES   2 C  456  ILE ASP LEU TYR TYR GLU ASP HIS GLY THR GLY THR PRO
SEQRES   3 C  456  VAL VAL LEU ILE HIS GLY PHE PRO LEU SER GLY HIS SER
SEQRES   4 C  456  TRP GLU ARG GLN SER ALA ALA LEU LEU ASP ALA GLY TYR
SEQRES   5 C  456  ARG VAL ILE THR TYR ASP ARG ARG GLY PHE GLY GLN SER
SEQRES   6 C  456  SER GLN PRO THR THR GLY TYR ASP TYR ASP THR PHE ALA
SEQRES   7 C  456  ALA ASP LEU ASN THR VAL LEU GLU THR LEU ASP LEU GLN
SEQRES   8 C  456  ASP ALA VAL LEU VAL GLY PHE SER MET GLY THR GLY GLU
SEQRES   9 C  456  VAL ALA ARG TYR VAL SER SER TYR GLY THR ALA ARG ILE
SEQRES  10 C  456  ALA ALA VAL ALA PHE LEU ALA SER LEU GLU PRO PHE LEU
SEQRES  11 C  456  LEU LYS THR ASP ASP ASN PRO ASP GLY ALA ALA PRO GLN
SEQRES  12 C  456  GLU PHE PHE ASP GLY ILE VAL ALA ALA VAL LYS ALA ASP
SEQRES  13 C  456  ARG TYR ALA PHE TYR THR GLY PHE PHE ASN ASP PHE TYR
SEQRES  14 C  456  ASN LEU ASP GLU ASN LEU GLY THR ARG ILE SER GLU GLU
SEQRES  15 C  456  ALA VAL ARG ASN SER TRP ASN THR ALA ALA SER GLY GLY
SEQRES  16 C  456  PHE PHE ALA ALA ALA ALA ALA PRO THR THR TRP TYR THR
SEQRES  17 C  456  ASP PHE ARG ALA ASP ILE PRO ARG ILE ASP VAL PRO ALA
SEQRES  18 C  456  LEU ILE LEU HIS GLY THR GLY ASP ARG THR LEU PRO ILE
SEQRES  19 C  456  GLU ASN THR ALA ARG VAL PHE HIS LYS ALA LEU PRO SER
SEQRES  20 C  456  ALA GLU TYR VAL GLU VAL GLU GLY ALA PRO HIS GLY LEU
SEQRES  21 C  456  LEU TRP THR HIS ALA GLU GLU VAL ASN THR ALA LEU LEU
SEQRES  22 C  456  ALA PHE LEU ALA LYS ALA GLN GLU ALA GLN LYS GLN LYS
SEQRES  23 C  456  LEU LEU THR GLU VAL GLU THR TYR VAL LEU SER ILE ILE
SEQRES  24 C  456  PRO SER GLY PRO LEU LYS ALA GLU ILE ALA GLN ARG LEU
SEQRES  25 C  456  GLU ASP VAL PHE ALA GLY LYS ASN THR ASP LEU GLU VAL
SEQRES  26 C  456  LEU MET GLU TRP LEU LYS THR ARG PRO ILE LEU SER PRO
SEQRES  27 C  456  LEU THR LYS GLY ILE LEU GLY PHE VAL PHE THR LEU THR
SEQRES  28 C  456  VAL PRO SER GLU ARG GLY LEU GLN ARG ARG ARG PHE VAL
SEQRES  29 C  456  GLN ASN ALA LEU ASN GLY ASN GLY ASP PRO ASN ASN MET
SEQRES  30 C  456  ASP LYS ALA VAL LYS LEU TYR ARG LYS LEU LYS ARG GLU
SEQRES  31 C  456  ILE THR PHE HIS GLY ALA LYS GLU ILE SER LEU SER TYR
SEQRES  32 C  456  SER ALA GLY ALA LEU ALA SER CYS MET GLY LEU ILE TYR
SEQRES  33 C  456  ASN ARG MET GLY ALA VAL THR THR GLU VAL ALA PHE GLY
SEQRES  34 C  456  LEU VAL CYS ALA THR CYS GLU GLN ILE ALA ASP SER GLN
SEQRES  35 C  456  HIS ARG SER HIS ARG GLN LEU GLU HIS HIS HIS HIS HIS
SEQRES  36 C  456  HIS
HELIX    1   1 SER A   35  SER A   38  5                                   4
HELIX    2   2 TRP A   39  ALA A   49  1                                  11
HELIX    3   3 ASP A   72  ASP A   88  1                                  17
HELIX    4   4 MET A   99  GLY A  112  1                                  14
HELIX    5   5 PRO A  141  ASP A  155  1                                  15
HELIX    6   6 ASP A  155  ASN A  169  1                                  15
HELIX    7   7 ASN A  169  LEU A  174  1                                   6
HELIX    8   8 SER A  179  SER A  192  1                                  14
HELIX    9   9 GLY A  194  TRP A  205  1                                  12
HELIX   10  10 ASP A  212  ILE A  216  5                                   5
HELIX   11  11 PRO A  232  LEU A  244  1                                  13
HELIX   12  12 GLY A  258  HIS A  263  1                                   6
HELIX   13  13 HIS A  263  SER A  296  1                                  34
HELIX   14  14 GLY A  301  ALA A  316  1                                  16
HELIX   15  15 ASP A  321  THR A  331  1                                  11
HELIX   16  16 SER A  336  VAL A  351  1                                  16
HELIX   17  17 ARG A  360  LEU A  367  1                                   8
HELIX   18  18 ASN A  368  GLY A  371  5                                   4
HELIX   19  19 ASP A  372  LYS A  387  1                                  16
HELIX   20  20 THR A  391  LEU A  400  1                                  10
HELIX   21  21 SER A  403  ASN A  416  1                                  14
HELIX   22  22 THR A  422  SER A  440  1                                  19
HELIX   23  23 SER B   35  SER B   38  5                                   4
HELIX   24  24 TRP B   39  GLY B   50  1                                  12
HELIX   25  25 ASP B   72  ASP B   88  1                                  17
HELIX   26  26 MET B   99  GLY B  112  1                                  14
HELIX   27  27 PRO B  141  ASP B  155  1                                  15
HELIX   28  28 ASP B  155  ASN B  169  1                                  15
HELIX   29  29 ASN B  169  LEU B  174  1                                   6
HELIX   30  30 SER B  179  SER B  192  1                                  14
HELIX   31  31 GLY B  194  TRP B  205  1                                  12
HELIX   32  32 ALA B  211  ILE B  216  1                                   6
HELIX   33  33 THR B  236  LEU B  244  1                                   9
HELIX   34  34 GLY B  258  SER B  296  1                                  39
HELIX   35  35 GLY B  301  ALA B  316  1                                  16
HELIX   36  36 ASP B  321  THR B  331  1                                  11
HELIX   37  37 SER B  336  VAL B  351  1                                  16
HELIX   38  38 ARG B  360  LEU B  367  1                                   8
HELIX   39  39 ASN B  368  GLY B  371  5                                   4
HELIX   40  40 ASP B  372  LYS B  387  1                                  16
HELIX   41  41 THR B  391  LEU B  400  1                                  10
HELIX   42  42 SER B  403  ASN B  416  1                                  14
HELIX   43  43 THR B  422  SER B  440  1                                  19
HELIX   44  44 SER C   35  SER C   38  5                                   4
HELIX   45  45 TRP C   39  GLY C   50  1                                  12
HELIX   46  46 ASP C   72  ASP C   88  1                                  17
HELIX   47  47 MET C   99  GLY C  112  1                                  14
HELIX   48  48 PRO C  141  ASP C  155  1                                  15
HELIX   49  49 ASP C  155  ASN C  169  1                                  15
HELIX   50  50 ASN C  169  LEU C  174  1                                   6
HELIX   51  51 SER C  179  SER C  192  1                                  14
HELIX   52  52 GLY C  194  TRP C  205  1                                  12
HELIX   53  53 ASP C  212  ILE C  216  5                                   5
HELIX   54  54 PRO C  232  LEU C  244  1                                  13
HELIX   55  55 GLY C  258  HIS C  263  1                                   6
HELIX   56  56 HIS C  263  SER C  296  1                                  34
HELIX   57  57 GLY C  301  ALA C  316  1                                  16
HELIX   58  58 ASP C  321  THR C  331  1                                  11
HELIX   59  59 SER C  336  VAL C  351  1                                  16
HELIX   60  60 ARG C  360  LEU C  367  1                                   8
HELIX   61  61 ASN C  368  GLY C  371  5                                   4
HELIX   62  62 ASP C  372  LYS C  387  1                                  16
HELIX   63  63 THR C  391  LEU C  400  1                                  10
HELIX   64  64 SER C  403  ASN C  416  1                                  14
HELIX   65  65 THR C  422  SER C  440  1                                  19
SHEET    1   A 8 PHE A   2  GLU A   8  0
SHEET    2   A 8 THR A  11  HIS A  20 -1  O  LEU A  15   N  ILE A   3
SHEET    3   A 8 ARG A  52  TYR A  56 -1  O  VAL A  53   N  HIS A  20
SHEET    4   A 8 PRO A  25  ILE A  29  1  N  VAL A  26   O  ILE A  54
SHEET    5   A 8 ALA A  92  PHE A  97  1  O  VAL A  93   N  VAL A  27
SHEET    6   A 8 ILE A 116  LEU A 122  1  O  ALA A 117   N  ALA A  92
SHEET    7   A 8 ALA A 220  GLY A 225  1  O  LEU A 223   N  PHE A 121
SHEET    8   A 8 GLU A 248  VAL A 252  1  O  VAL A 252   N  HIS A 224
SHEET    1   B 8 PHE B   2  GLU B   8  0
SHEET    2   B 8 THR B  11  HIS B  20 -1  O  LEU B  15   N  ILE B   3
SHEET    3   B 8 TYR B  51  TYR B  56 -1  O  VAL B  53   N  HIS B  20
SHEET    4   B 8 THR B  24  ILE B  29  1  N  VAL B  26   O  ILE B  54
SHEET    5   B 8 ALA B  92  PHE B  97  1  O  VAL B  93   N  VAL B  27
SHEET    6   B 8 ILE B 116  LEU B 122  1  O  ALA B 120   N  LEU B  94
SHEET    7   B 8 ALA B 220  GLY B 225  1  O  LEU B 221   N  PHE B 121
SHEET    8   B 8 GLU B 248  VAL B 252  1  O  VAL B 252   N  HIS B 224
SHEET    1   C 8 PHE C   2  GLU C   8  0
SHEET    2   C 8 THR C  11  HIS C  20 -1  O  LEU C  15   N  ILE C   3
SHEET    3   C 8 ARG C  52  TYR C  56 -1  O  VAL C  53   N  HIS C  20
SHEET    4   C 8 PRO C  25  ILE C  29  1  N  VAL C  26   O  ILE C  54
SHEET    5   C 8 ALA C  92  PHE C  97  1  O  VAL C  93   N  VAL C  27
SHEET    6   C 8 ILE C 116  LEU C 122  1  O  ALA C 117   N  ALA C  92
SHEET    7   C 8 ALA C 220  GLY C 225  1  O  LEU C 223   N  PHE C 121
SHEET    8   C 8 GLU C 248  VAL C 252  1  O  VAL C 252   N  HIS C 224
CISPEP   1 PHE A   32    PRO A   33          0        -3.90
CISPEP   2 GLU A  126    PRO A  127          0       -12.19
CISPEP   3 PHE B   32    PRO B   33          0        -3.65
CISPEP   4 GLU B  126    PRO B  127          0        -2.94
CISPEP   5 PHE C   32    PRO C   33          0        -3.53
CISPEP   6 GLU C  126    PRO C  127          0       -11.00
CRYST1  129.670  160.980  167.630  90.00  90.00  90.00 I 2 2 2      24
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.007712  0.000000  0.000000        0.00000
SCALE2      0.000000  0.006212  0.000000        0.00000
SCALE3      0.000000  0.000000  0.005966        0.00000
TER    3399      SER A 440
TER    6798      SER B 440
TER   10197      SER C 440
MASTER      408    0    0   65   24    0    0    610194    3    0  108
END