longtext: 4qes-pdb

content
HEADER    OXIDOREDUCTASE, VIRAL PROTEIN           18-MAY-14   4QES
TITLE     STRUCTURE OF A 16 NM PROTEIN CAGE DESIGNED BY FUSING SYMMETRIC
TITLE    2 OLIGOMERIC DOMAINS, QUADRUPLE MUTANT, I222 FORM
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: NON-HAEM BROMOPEROXIDASE BPO-A2, MATRIX PROTEIN 1 CHIMERA;
COMPND   3 CHAIN: A, B, C;
COMPND   4 FRAGMENT: SEE REMARK 999;
COMPND   5 SYNONYM: DESIGNED 16NM TETRAHEDRAL PROTEIN CAGE, BPO2, BROMIDE
COMPND   6 PEROXIDASE, M1;
COMPND   7 EC: 1.11.1.-;
COMPND   8 ENGINEERED: YES;
COMPND   9 MUTATION: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: STREPTOMYCES AUREOFACIENS, INFLUENZA A VIRUS;
SOURCE   3 ORGANISM_TAXID: 1894, 11320;
SOURCE   4 GENE: BPOA2, M;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE   7 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);
SOURCE   8 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE   9 EXPRESSION_SYSTEM_PLASMID: PET22B
KEYWDS    PROTEIN DESIGN, BIONANOTECHNOLOGY, PROTEIN ASSEMBLY, SYMMETRY,
KEYWDS   2 BIOMATERIALS, OXIDOREDUCTASE, VIRAL PROTEIN
EXPDTA    X-RAY DIFFRACTION
AUTHOR    Y.-T.LAI,T.O.YEATES
REVDAT   1   20-MAY-15 4QES    0
JRNL        AUTH   Y.-T.LAI,T.O.YEATES
JRNL        TITL   STRUCTURAL TRANSITION OF A PROTEIN NANOCAGE AS A FUNCTION OF
JRNL        TITL 2 PH AND SALT CONCENTRATION.
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    4.19 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.8.0071
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 4.19
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 83.83
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.7
REMARK   3   NUMBER OF REFLECTIONS             : 12914
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.254
REMARK   3   R VALUE            (WORKING SET) : 0.251
REMARK   3   FREE R VALUE                     : 0.295
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000
REMARK   3   FREE R VALUE TEST SET COUNT      : 646
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 4.19
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 4.30
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 865
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 96.40
REMARK   3   BIN R VALUE           (WORKING SET) : 0.3250
REMARK   3   BIN FREE R VALUE SET COUNT          : 45
REMARK   3   BIN FREE R VALUE                    : 0.3260
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 10128
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 0
REMARK   3   SOLVENT ATOMS            : 0
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 161.22
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 198.02
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : 0.88000
REMARK   3    B22 (A**2) : -3.72000
REMARK   3    B33 (A**2) : 2.84000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : -0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): NULL
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 1.144
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.981
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 76.252
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.911
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.938
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A): 10359 ; 0.009 ; 0.019
REMARK   3   BOND LENGTHS OTHERS               (A):  9666 ; 0.004 ; 0.020
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 14112 ; 1.440 ; 1.953
REMARK   3   BOND ANGLES OTHERS          (DEGREES): 22149 ; 0.949 ; 3.000
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  1320 ; 4.271 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   465 ;35.453 ;23.742
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  1575 ;15.472 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    66 ;19.286 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  1605 ; 0.075 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A): 11946 ; 0.005 ; 0.021
REMARK   3   GENERAL PLANES OTHERS             (A):  2436 ; 0.003 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  5289 ;17.367 ;19.675
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  5288 ;17.368 ;19.674
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  6606 ;28.124 ;29.476
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2):  NULL ;  NULL ;  NULL
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NCS TYPE: LOCAL
REMARK   3   NUMBER OF DIFFERENT NCS PAIRS  : 3
REMARK   3  GROUP  CHAIN1    RANGE     CHAIN2     RANGE    COUNT RMS  WEIGHT
REMARK   3    1      A     1   441       B     1    441    27229 0.050 0.050
REMARK   3    2      A     1   441       C     1    441    27171 0.060 0.050
REMARK   3    3      B     1   441       C     1    441    27228 0.050 0.050
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING
REMARK   3  POSITIONS
REMARK   4
REMARK   4 4QES COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 28-MAY-14.
REMARK 100 THE RCSB ID CODE IS RCSB085963.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 28-FEB-14
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 4.4
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : APS
REMARK 200  BEAMLINE                       : 24-ID-C
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9789
REMARK 200  MONOCHROMATOR                  : CRYO-COOLED DOUBLE CRYSTAL
REMARK 200                                   SI(111)
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 6M-F
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : NULL
REMARK 200  DATA SCALING SOFTWARE          : XSCALE
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 12914
REMARK 200  RESOLUTION RANGE HIGH      (A) : 4.190
REMARK 200  RESOLUTION RANGE LOW       (A) : 83.835
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : -3.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.7
REMARK 200  DATA REDUNDANCY                : NULL
REMARK 200  R MERGE                    (I) : 0.12700
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 14.1600
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 4.19
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 4.30
REMARK 200  COMPLETENESS FOR SHELL     (%) : 96.4
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : 0.88500
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 3.320
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 56.78
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.85
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1 M SODIUM CITRATE, PH 4.4, 11%
REMARK 280  PEG3000, 200 MM SODIUM CHLORIDE, VAPOR DIFFUSION, HANGING DROP,
REMARK 280  TEMPERATURE 298K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: I 2 2 2
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,-Y,Z
REMARK 290       3555   -X,Y,-Z
REMARK 290       4555   X,-Y,-Z
REMARK 290       5555   X+1/2,Y+1/2,Z+1/2
REMARK 290       6555   -X+1/2,-Y+1/2,Z+1/2
REMARK 290       7555   -X+1/2,Y+1/2,-Z+1/2
REMARK 290       8555   X+1/2,-Y+1/2,-Z+1/2
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   5  1.000000  0.000000  0.000000       61.75500
REMARK 290   SMTRY2   5  0.000000  1.000000  0.000000       82.76000
REMARK 290   SMTRY3   5  0.000000  0.000000  1.000000       83.83500
REMARK 290   SMTRY1   6 -1.000000  0.000000  0.000000       61.75500
REMARK 290   SMTRY2   6  0.000000 -1.000000  0.000000       82.76000
REMARK 290   SMTRY3   6  0.000000  0.000000  1.000000       83.83500
REMARK 290   SMTRY1   7 -1.000000  0.000000  0.000000       61.75500
REMARK 290   SMTRY2   7  0.000000  1.000000  0.000000       82.76000
REMARK 290   SMTRY3   7  0.000000  0.000000 -1.000000       83.83500
REMARK 290   SMTRY1   8  1.000000  0.000000  0.000000       61.75500
REMARK 290   SMTRY2   8  0.000000 -1.000000  0.000000       82.76000
REMARK 290   SMTRY3   8  0.000000  0.000000 -1.000000       83.83500
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DODECAMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DODECAMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 34160 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 186590 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -102.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, C, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350   BIOMT1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 350   BIOMT3   2  0.000000  0.000000  1.000000        0.00000
REMARK 350   BIOMT1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   3  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   3  0.000000  0.000000 -1.000000        0.00000
REMARK 350   BIOMT1   4  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   4  0.000000 -1.000000  0.000000        0.00000
REMARK 350   BIOMT3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A     0
REMARK 465     HIS A   442
REMARK 465     ARG A   443
REMARK 465     SER A   444
REMARK 465     HIS A   445
REMARK 465     ARG A   446
REMARK 465     GLN A   447
REMARK 465     LEU A   448
REMARK 465     GLU A   449
REMARK 465     HIS A   450
REMARK 465     HIS A   451
REMARK 465     HIS A   452
REMARK 465     HIS A   453
REMARK 465     HIS A   454
REMARK 465     HIS A   455
REMARK 465     MET B     0
REMARK 465     HIS B   442
REMARK 465     ARG B   443
REMARK 465     SER B   444
REMARK 465     HIS B   445
REMARK 465     ARG B   446
REMARK 465     GLN B   447
REMARK 465     LEU B   448
REMARK 465     GLU B   449
REMARK 465     HIS B   450
REMARK 465     HIS B   451
REMARK 465     HIS B   452
REMARK 465     HIS B   453
REMARK 465     HIS B   454
REMARK 465     HIS B   455
REMARK 465     MET C     0
REMARK 465     HIS C   442
REMARK 465     ARG C   443
REMARK 465     SER C   444
REMARK 465     HIS C   445
REMARK 465     ARG C   446
REMARK 465     GLN C   447
REMARK 465     LEU C   448
REMARK 465     GLU C   449
REMARK 465     HIS C   450
REMARK 465     HIS C   451
REMARK 465     HIS C   452
REMARK 465     HIS C   453
REMARK 465     HIS C   454
REMARK 465     HIS C   455
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     GLN A 279    CG   CD   OE1  NE2
REMARK 470     GLU A 280    CG   CD   OE1  OE2
REMARK 470     GLN A 282    CG   CD   OE1  NE2
REMARK 470     LYS A 283    CG   CD   CE   NZ
REMARK 470     GLN A 284    CG   CD   OE1  NE2
REMARK 470     LYS A 285    CG   CD   CE   NZ
REMARK 470     GLN B 279    CG   CD   OE1  NE2
REMARK 470     GLU B 280    CG   CD   OE1  OE2
REMARK 470     GLN B 282    CG   CD   OE1  NE2
REMARK 470     LYS B 283    CG   CD   CE   NZ
REMARK 470     GLN B 284    CG   CD   OE1  NE2
REMARK 470     LYS B 285    CG   CD   CE   NZ
REMARK 470     GLN C 279    CG   CD   OE1  NE2
REMARK 470     GLU C 280    CG   CD   OE1  OE2
REMARK 470     GLN C 282    CG   CD   OE1  NE2
REMARK 470     LYS C 283    CG   CD   CE   NZ
REMARK 470     GLN C 284    CG   CD   OE1  NE2
REMARK 470     LYS C 285    CG   CD   CE   NZ
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ASN A   9     -121.97     50.94
REMARK 500    PRO A  33       40.28   -105.84
REMARK 500    SER A  98     -120.19     55.39
REMARK 500    THR A 176      -79.02   -126.45
REMARK 500    TYR A 206       34.77    -98.78
REMARK 500    THR A 236      -68.34   -127.26
REMARK 500    ILE A 334      -54.73     73.11
REMARK 500    ASN B   9     -121.62     50.40
REMARK 500    PRO B  33       40.33   -105.91
REMARK 500    SER B  98     -120.01     55.56
REMARK 500    PHE B 128      135.13   -170.24
REMARK 500    THR B 176      -79.39   -126.92
REMARK 500    TYR B 206       34.81    -98.37
REMARK 500    THR B 236      -69.90   -127.03
REMARK 500    ILE B 334      -54.99     72.26
REMARK 500    ASN C   9     -121.92     50.76
REMARK 500    SER C  98     -119.84     54.85
REMARK 500    THR C 176      -78.80   -126.69
REMARK 500    TYR C 206       35.05    -98.79
REMARK 500    THR C 236      -76.46   -126.48
REMARK 500    ILE C 334      -55.73     72.56
REMARK 500
REMARK 500 REMARK: NULL
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 4QF0   RELATED DB: PDB
REMARK 900 RELATED ID: 4QFF   RELATED DB: PDB
REMARK 999
REMARK 999 SEQUENCE
REMARK 999 THE DESIGNED PROTEIN CONSTRUCT IS A CHIMERA COMPRISING BPO2 (UNP
REMARK 999 P29715) AND RESIDUES 2-164 (UNP P03485) OF M1, SEPARATED BY A
REMARK 999 LINKER.
DBREF  4QES A    0   277  UNP    P29715   BPOA2_STRAU      1    278
DBREF  4QES A  286   447  UNP    P03485   M1_I34A1         3    164
DBREF  4QES B    0   277  UNP    P29715   BPOA2_STRAU      1    278
DBREF  4QES B  286   447  UNP    P03485   M1_I34A1         3    164
DBREF  4QES C    0   277  UNP    P29715   BPOA2_STRAU      1    278
DBREF  4QES C  286   447  UNP    P03485   M1_I34A1         3    164
SEQADV 4QES THR A   24  UNP  P29715    GLN    25 ENGINEERED MUTATION
SEQADV 4QES ALA A   51  UNP  P29715    TYR    52 ENGINEERED MUTATION
SEQADV 4QES ALA A  118  UNP  P29715    LYS   119 ENGINEERED MUTATION
SEQADV 4QES ALA A  278  UNP  P03485              LINKER
SEQADV 4QES GLN A  279  UNP  P03485              LINKER
SEQADV 4QES GLU A  280  UNP  P03485              LINKER
SEQADV 4QES ALA A  281  UNP  P03485              LINKER
SEQADV 4QES GLN A  282  UNP  P03485              LINKER
SEQADV 4QES LYS A  283  UNP  P03485              LINKER
SEQADV 4QES GLN A  284  UNP  P03485              LINKER
SEQADV 4QES LYS A  285  UNP  P03485              LINKER
SEQADV 4QES LEU A  448  UNP  P03485              EXPRESSION TAG
SEQADV 4QES GLU A  449  UNP  P03485              EXPRESSION TAG
SEQADV 4QES HIS A  450  UNP  P03485              EXPRESSION TAG
SEQADV 4QES HIS A  451  UNP  P03485              EXPRESSION TAG
SEQADV 4QES HIS A  452  UNP  P03485              EXPRESSION TAG
SEQADV 4QES HIS A  453  UNP  P03485              EXPRESSION TAG
SEQADV 4QES HIS A  454  UNP  P03485              EXPRESSION TAG
SEQADV 4QES HIS A  455  UNP  P03485              EXPRESSION TAG
SEQADV 4QES THR B   24  UNP  P29715    GLN    25 ENGINEERED MUTATION
SEQADV 4QES ALA B   51  UNP  P29715    TYR    52 ENGINEERED MUTATION
SEQADV 4QES ALA B  118  UNP  P29715    LYS   119 ENGINEERED MUTATION
SEQADV 4QES ALA B  278  UNP  P03485              LINKER
SEQADV 4QES GLN B  279  UNP  P03485              LINKER
SEQADV 4QES GLU B  280  UNP  P03485              LINKER
SEQADV 4QES ALA B  281  UNP  P03485              LINKER
SEQADV 4QES GLN B  282  UNP  P03485              LINKER
SEQADV 4QES LYS B  283  UNP  P03485              LINKER
SEQADV 4QES GLN B  284  UNP  P03485              LINKER
SEQADV 4QES LYS B  285  UNP  P03485              LINKER
SEQADV 4QES LEU B  448  UNP  P03485              EXPRESSION TAG
SEQADV 4QES GLU B  449  UNP  P03485              EXPRESSION TAG
SEQADV 4QES HIS B  450  UNP  P03485              EXPRESSION TAG
SEQADV 4QES HIS B  451  UNP  P03485              EXPRESSION TAG
SEQADV 4QES HIS B  452  UNP  P03485              EXPRESSION TAG
SEQADV 4QES HIS B  453  UNP  P03485              EXPRESSION TAG
SEQADV 4QES HIS B  454  UNP  P03485              EXPRESSION TAG
SEQADV 4QES HIS B  455  UNP  P03485              EXPRESSION TAG
SEQADV 4QES THR C   24  UNP  P29715    GLN    25 ENGINEERED MUTATION
SEQADV 4QES ALA C   51  UNP  P29715    TYR    52 ENGINEERED MUTATION
SEQADV 4QES ALA C  118  UNP  P29715    LYS   119 ENGINEERED MUTATION
SEQADV 4QES ALA C  278  UNP  P03485              LINKER
SEQADV 4QES GLN C  279  UNP  P03485              LINKER
SEQADV 4QES GLU C  280  UNP  P03485              LINKER
SEQADV 4QES ALA C  281  UNP  P03485              LINKER
SEQADV 4QES GLN C  282  UNP  P03485              LINKER
SEQADV 4QES LYS C  283  UNP  P03485              LINKER
SEQADV 4QES GLN C  284  UNP  P03485              LINKER
SEQADV 4QES LYS C  285  UNP  P03485              LINKER
SEQADV 4QES LEU C  448  UNP  P03485              EXPRESSION TAG
SEQADV 4QES GLU C  449  UNP  P03485              EXPRESSION TAG
SEQADV 4QES HIS C  450  UNP  P03485              EXPRESSION TAG
SEQADV 4QES HIS C  451  UNP  P03485              EXPRESSION TAG
SEQADV 4QES HIS C  452  UNP  P03485              EXPRESSION TAG
SEQADV 4QES HIS C  453  UNP  P03485              EXPRESSION TAG
SEQADV 4QES HIS C  454  UNP  P03485              EXPRESSION TAG
SEQADV 4QES HIS C  455  UNP  P03485              EXPRESSION TAG
SEQRES   1 A  456  MET PRO PHE ILE THR VAL GLY GLN GLU ASN SER THR SER
SEQRES   2 A  456  ILE ASP LEU TYR TYR GLU ASP HIS GLY THR GLY THR PRO
SEQRES   3 A  456  VAL VAL LEU ILE HIS GLY PHE PRO LEU SER GLY HIS SER
SEQRES   4 A  456  TRP GLU ARG GLN SER ALA ALA LEU LEU ASP ALA GLY ALA
SEQRES   5 A  456  ARG VAL ILE THR TYR ASP ARG ARG GLY PHE GLY GLN SER
SEQRES   6 A  456  SER GLN PRO THR THR GLY TYR ASP TYR ASP THR PHE ALA
SEQRES   7 A  456  ALA ASP LEU ASN THR VAL LEU GLU THR LEU ASP LEU GLN
SEQRES   8 A  456  ASP ALA VAL LEU VAL GLY PHE SER MET GLY THR GLY GLU
SEQRES   9 A  456  VAL ALA ARG TYR VAL SER SER TYR GLY THR ALA ARG ILE
SEQRES  10 A  456  ALA ALA VAL ALA PHE LEU ALA SER LEU GLU PRO PHE LEU
SEQRES  11 A  456  LEU LYS THR ASP ASP ASN PRO ASP GLY ALA ALA PRO GLN
SEQRES  12 A  456  GLU PHE PHE ASP GLY ILE VAL ALA ALA VAL LYS ALA ASP
SEQRES  13 A  456  ARG TYR ALA PHE TYR THR GLY PHE PHE ASN ASP PHE TYR
SEQRES  14 A  456  ASN LEU ASP GLU ASN LEU GLY THR ARG ILE SER GLU GLU
SEQRES  15 A  456  ALA VAL ARG ASN SER TRP ASN THR ALA ALA SER GLY GLY
SEQRES  16 A  456  PHE PHE ALA ALA ALA ALA ALA PRO THR THR TRP TYR THR
SEQRES  17 A  456  ASP PHE ARG ALA ASP ILE PRO ARG ILE ASP VAL PRO ALA
SEQRES  18 A  456  LEU ILE LEU HIS GLY THR GLY ASP ARG THR LEU PRO ILE
SEQRES  19 A  456  GLU ASN THR ALA ARG VAL PHE HIS LYS ALA LEU PRO SER
SEQRES  20 A  456  ALA GLU TYR VAL GLU VAL GLU GLY ALA PRO HIS GLY LEU
SEQRES  21 A  456  LEU TRP THR HIS ALA GLU GLU VAL ASN THR ALA LEU LEU
SEQRES  22 A  456  ALA PHE LEU ALA LYS ALA GLN GLU ALA GLN LYS GLN LYS
SEQRES  23 A  456  LEU LEU THR GLU VAL GLU THR TYR VAL LEU SER ILE ILE
SEQRES  24 A  456  PRO SER GLY PRO LEU LYS ALA GLU ILE ALA GLN ARG LEU
SEQRES  25 A  456  GLU ASP VAL PHE ALA GLY LYS ASN THR ASP LEU GLU VAL
SEQRES  26 A  456  LEU MET GLU TRP LEU LYS THR ARG PRO ILE LEU SER PRO
SEQRES  27 A  456  LEU THR LYS GLY ILE LEU GLY PHE VAL PHE THR LEU THR
SEQRES  28 A  456  VAL PRO SER GLU ARG GLY LEU GLN ARG ARG ARG PHE VAL
SEQRES  29 A  456  GLN ASN ALA LEU ASN GLY ASN GLY ASP PRO ASN ASN MET
SEQRES  30 A  456  ASP LYS ALA VAL LYS LEU TYR ARG LYS LEU LYS ARG GLU
SEQRES  31 A  456  ILE THR PHE HIS GLY ALA LYS GLU ILE SER LEU SER TYR
SEQRES  32 A  456  SER ALA GLY ALA LEU ALA SER CYS MET GLY LEU ILE TYR
SEQRES  33 A  456  ASN ARG MET GLY ALA VAL THR THR GLU VAL ALA PHE GLY
SEQRES  34 A  456  LEU VAL CYS ALA THR CYS GLU GLN ILE ALA ASP SER GLN
SEQRES  35 A  456  HIS ARG SER HIS ARG GLN LEU GLU HIS HIS HIS HIS HIS
SEQRES  36 A  456  HIS
SEQRES   1 B  456  MET PRO PHE ILE THR VAL GLY GLN GLU ASN SER THR SER
SEQRES   2 B  456  ILE ASP LEU TYR TYR GLU ASP HIS GLY THR GLY THR PRO
SEQRES   3 B  456  VAL VAL LEU ILE HIS GLY PHE PRO LEU SER GLY HIS SER
SEQRES   4 B  456  TRP GLU ARG GLN SER ALA ALA LEU LEU ASP ALA GLY ALA
SEQRES   5 B  456  ARG VAL ILE THR TYR ASP ARG ARG GLY PHE GLY GLN SER
SEQRES   6 B  456  SER GLN PRO THR THR GLY TYR ASP TYR ASP THR PHE ALA
SEQRES   7 B  456  ALA ASP LEU ASN THR VAL LEU GLU THR LEU ASP LEU GLN
SEQRES   8 B  456  ASP ALA VAL LEU VAL GLY PHE SER MET GLY THR GLY GLU
SEQRES   9 B  456  VAL ALA ARG TYR VAL SER SER TYR GLY THR ALA ARG ILE
SEQRES  10 B  456  ALA ALA VAL ALA PHE LEU ALA SER LEU GLU PRO PHE LEU
SEQRES  11 B  456  LEU LYS THR ASP ASP ASN PRO ASP GLY ALA ALA PRO GLN
SEQRES  12 B  456  GLU PHE PHE ASP GLY ILE VAL ALA ALA VAL LYS ALA ASP
SEQRES  13 B  456  ARG TYR ALA PHE TYR THR GLY PHE PHE ASN ASP PHE TYR
SEQRES  14 B  456  ASN LEU ASP GLU ASN LEU GLY THR ARG ILE SER GLU GLU
SEQRES  15 B  456  ALA VAL ARG ASN SER TRP ASN THR ALA ALA SER GLY GLY
SEQRES  16 B  456  PHE PHE ALA ALA ALA ALA ALA PRO THR THR TRP TYR THR
SEQRES  17 B  456  ASP PHE ARG ALA ASP ILE PRO ARG ILE ASP VAL PRO ALA
SEQRES  18 B  456  LEU ILE LEU HIS GLY THR GLY ASP ARG THR LEU PRO ILE
SEQRES  19 B  456  GLU ASN THR ALA ARG VAL PHE HIS LYS ALA LEU PRO SER
SEQRES  20 B  456  ALA GLU TYR VAL GLU VAL GLU GLY ALA PRO HIS GLY LEU
SEQRES  21 B  456  LEU TRP THR HIS ALA GLU GLU VAL ASN THR ALA LEU LEU
SEQRES  22 B  456  ALA PHE LEU ALA LYS ALA GLN GLU ALA GLN LYS GLN LYS
SEQRES  23 B  456  LEU LEU THR GLU VAL GLU THR TYR VAL LEU SER ILE ILE
SEQRES  24 B  456  PRO SER GLY PRO LEU LYS ALA GLU ILE ALA GLN ARG LEU
SEQRES  25 B  456  GLU ASP VAL PHE ALA GLY LYS ASN THR ASP LEU GLU VAL
SEQRES  26 B  456  LEU MET GLU TRP LEU LYS THR ARG PRO ILE LEU SER PRO
SEQRES  27 B  456  LEU THR LYS GLY ILE LEU GLY PHE VAL PHE THR LEU THR
SEQRES  28 B  456  VAL PRO SER GLU ARG GLY LEU GLN ARG ARG ARG PHE VAL
SEQRES  29 B  456  GLN ASN ALA LEU ASN GLY ASN GLY ASP PRO ASN ASN MET
SEQRES  30 B  456  ASP LYS ALA VAL LYS LEU TYR ARG LYS LEU LYS ARG GLU
SEQRES  31 B  456  ILE THR PHE HIS GLY ALA LYS GLU ILE SER LEU SER TYR
SEQRES  32 B  456  SER ALA GLY ALA LEU ALA SER CYS MET GLY LEU ILE TYR
SEQRES  33 B  456  ASN ARG MET GLY ALA VAL THR THR GLU VAL ALA PHE GLY
SEQRES  34 B  456  LEU VAL CYS ALA THR CYS GLU GLN ILE ALA ASP SER GLN
SEQRES  35 B  456  HIS ARG SER HIS ARG GLN LEU GLU HIS HIS HIS HIS HIS
SEQRES  36 B  456  HIS
SEQRES   1 C  456  MET PRO PHE ILE THR VAL GLY GLN GLU ASN SER THR SER
SEQRES   2 C  456  ILE ASP LEU TYR TYR GLU ASP HIS GLY THR GLY THR PRO
SEQRES   3 C  456  VAL VAL LEU ILE HIS GLY PHE PRO LEU SER GLY HIS SER
SEQRES   4 C  456  TRP GLU ARG GLN SER ALA ALA LEU LEU ASP ALA GLY ALA
SEQRES   5 C  456  ARG VAL ILE THR TYR ASP ARG ARG GLY PHE GLY GLN SER
SEQRES   6 C  456  SER GLN PRO THR THR GLY TYR ASP TYR ASP THR PHE ALA
SEQRES   7 C  456  ALA ASP LEU ASN THR VAL LEU GLU THR LEU ASP LEU GLN
SEQRES   8 C  456  ASP ALA VAL LEU VAL GLY PHE SER MET GLY THR GLY GLU
SEQRES   9 C  456  VAL ALA ARG TYR VAL SER SER TYR GLY THR ALA ARG ILE
SEQRES  10 C  456  ALA ALA VAL ALA PHE LEU ALA SER LEU GLU PRO PHE LEU
SEQRES  11 C  456  LEU LYS THR ASP ASP ASN PRO ASP GLY ALA ALA PRO GLN
SEQRES  12 C  456  GLU PHE PHE ASP GLY ILE VAL ALA ALA VAL LYS ALA ASP
SEQRES  13 C  456  ARG TYR ALA PHE TYR THR GLY PHE PHE ASN ASP PHE TYR
SEQRES  14 C  456  ASN LEU ASP GLU ASN LEU GLY THR ARG ILE SER GLU GLU
SEQRES  15 C  456  ALA VAL ARG ASN SER TRP ASN THR ALA ALA SER GLY GLY
SEQRES  16 C  456  PHE PHE ALA ALA ALA ALA ALA PRO THR THR TRP TYR THR
SEQRES  17 C  456  ASP PHE ARG ALA ASP ILE PRO ARG ILE ASP VAL PRO ALA
SEQRES  18 C  456  LEU ILE LEU HIS GLY THR GLY ASP ARG THR LEU PRO ILE
SEQRES  19 C  456  GLU ASN THR ALA ARG VAL PHE HIS LYS ALA LEU PRO SER
SEQRES  20 C  456  ALA GLU TYR VAL GLU VAL GLU GLY ALA PRO HIS GLY LEU
SEQRES  21 C  456  LEU TRP THR HIS ALA GLU GLU VAL ASN THR ALA LEU LEU
SEQRES  22 C  456  ALA PHE LEU ALA LYS ALA GLN GLU ALA GLN LYS GLN LYS
SEQRES  23 C  456  LEU LEU THR GLU VAL GLU THR TYR VAL LEU SER ILE ILE
SEQRES  24 C  456  PRO SER GLY PRO LEU LYS ALA GLU ILE ALA GLN ARG LEU
SEQRES  25 C  456  GLU ASP VAL PHE ALA GLY LYS ASN THR ASP LEU GLU VAL
SEQRES  26 C  456  LEU MET GLU TRP LEU LYS THR ARG PRO ILE LEU SER PRO
SEQRES  27 C  456  LEU THR LYS GLY ILE LEU GLY PHE VAL PHE THR LEU THR
SEQRES  28 C  456  VAL PRO SER GLU ARG GLY LEU GLN ARG ARG ARG PHE VAL
SEQRES  29 C  456  GLN ASN ALA LEU ASN GLY ASN GLY ASP PRO ASN ASN MET
SEQRES  30 C  456  ASP LYS ALA VAL LYS LEU TYR ARG LYS LEU LYS ARG GLU
SEQRES  31 C  456  ILE THR PHE HIS GLY ALA LYS GLU ILE SER LEU SER TYR
SEQRES  32 C  456  SER ALA GLY ALA LEU ALA SER CYS MET GLY LEU ILE TYR
SEQRES  33 C  456  ASN ARG MET GLY ALA VAL THR THR GLU VAL ALA PHE GLY
SEQRES  34 C  456  LEU VAL CYS ALA THR CYS GLU GLN ILE ALA ASP SER GLN
SEQRES  35 C  456  HIS ARG SER HIS ARG GLN LEU GLU HIS HIS HIS HIS HIS
SEQRES  36 C  456  HIS
HELIX    1   1 SER A   35  SER A   38  5                                   4
HELIX    2   2 TRP A   39  ALA A   49  1                                  11
HELIX    3   3 ASP A   72  ASP A   88  1                                  17
HELIX    4   4 MET A   99  GLY A  112  1                                  14
HELIX    5   5 PRO A  141  ASP A  155  1                                  15
HELIX    6   6 ARG A  156  ASN A  169  1                                  14
HELIX    7   7 ASN A  169  LEU A  174  1                                   6
HELIX    8   8 SER A  179  SER A  192  1                                  14
HELIX    9   9 GLY A  194  TRP A  205  1                                  12
HELIX   10  10 ASP A  212  ILE A  216  5                                   5
HELIX   11  11 PRO A  232  LEU A  244  1                                  13
HELIX   12  12 GLY A  258  HIS A  263  1                                   6
HELIX   13  13 HIS A  263  SER A  296  1                                  34
HELIX   14  14 GLY A  301  ALA A  316  1                                  16
HELIX   15  15 ASP A  321  THR A  331  1                                  11
HELIX   16  16 SER A  336  VAL A  351  1                                  16
HELIX   17  17 ARG A  360  LEU A  367  1                                   8
HELIX   18  18 ASN A  368  GLY A  371  5                                   4
HELIX   19  19 ASP A  372  LYS A  387  1                                  16
HELIX   20  20 THR A  391  LEU A  400  1                                  10
HELIX   21  21 SER A  403  ASN A  416  1                                  14
HELIX   22  22 THR A  422  GLN A  441  1                                  20
HELIX   23  23 SER B   35  SER B   38  5                                   4
HELIX   24  24 TRP B   39  ALA B   49  1                                  11
HELIX   25  25 ASP B   72  ASP B   88  1                                  17
HELIX   26  26 MET B   99  GLY B  112  1                                  14
HELIX   27  27 PRO B  141  ASP B  155  1                                  15
HELIX   28  28 ARG B  156  ASN B  169  1                                  14
HELIX   29  29 ASN B  169  LEU B  174  1                                   6
HELIX   30  30 SER B  179  SER B  192  1                                  14
HELIX   31  31 GLY B  194  TRP B  205  1                                  12
HELIX   32  32 ASP B  212  ILE B  216  5                                   5
HELIX   33  33 PRO B  232  LEU B  244  1                                  13
HELIX   34  34 GLY B  258  HIS B  263  1                                   6
HELIX   35  35 HIS B  263  SER B  296  1                                  34
HELIX   36  36 GLY B  301  ALA B  316  1                                  16
HELIX   37  37 ASP B  321  THR B  331  1                                  11
HELIX   38  38 SER B  336  VAL B  351  1                                  16
HELIX   39  39 ARG B  360  LEU B  367  1                                   8
HELIX   40  40 ASN B  368  GLY B  371  5                                   4
HELIX   41  41 ASP B  372  ARG B  388  1                                  17
HELIX   42  42 THR B  391  LEU B  400  1                                  10
HELIX   43  43 SER B  403  ASN B  416  1                                  14
HELIX   44  44 THR B  422  GLN B  441  1                                  20
HELIX   45  45 SER C   35  SER C   38  5                                   4
HELIX   46  46 TRP C   39  ALA C   49  1                                  11
HELIX   47  47 ASP C   72  ASP C   88  1                                  17
HELIX   48  48 MET C   99  GLY C  112  1                                  14
HELIX   49  49 PRO C  141  ASP C  155  1                                  15
HELIX   50  50 ARG C  156  ASN C  169  1                                  14
HELIX   51  51 ASN C  169  LEU C  174  1                                   6
HELIX   52  52 SER C  179  SER C  192  1                                  14
HELIX   53  53 GLY C  194  TRP C  205  1                                  12
HELIX   54  54 ASP C  212  ILE C  216  5                                   5
HELIX   55  55 THR C  236  LEU C  244  1                                   9
HELIX   56  56 GLY C  258  HIS C  263  1                                   6
HELIX   57  57 HIS C  263  SER C  296  1                                  34
HELIX   58  58 GLY C  301  ALA C  316  1                                  16
HELIX   59  59 ASP C  321  THR C  331  1                                  11
HELIX   60  60 SER C  336  VAL C  351  1                                  16
HELIX   61  61 ARG C  360  LEU C  367  1                                   8
HELIX   62  62 ASN C  368  GLY C  371  5                                   4
HELIX   63  63 ASP C  372  ARG C  388  1                                  17
HELIX   64  64 THR C  391  LEU C  400  1                                  10
HELIX   65  65 SER C  403  ASN C  416  1                                  14
HELIX   66  66 THR C  422  GLN C  441  1                                  20
SHEET    1   A 8 PHE A   2  GLU A   8  0
SHEET    2   A 8 THR A  11  HIS A  20 -1  O  LEU A  15   N  ILE A   3
SHEET    3   A 8 ARG A  52  TYR A  56 -1  O  VAL A  53   N  HIS A  20
SHEET    4   A 8 PRO A  25  ILE A  29  1  N  VAL A  26   O  ARG A  52
SHEET    5   A 8 ALA A  92  PHE A  97  1  O  VAL A  93   N  VAL A  27
SHEET    6   A 8 ILE A 116  LEU A 122  1  O  ALA A 117   N  ALA A  92
SHEET    7   A 8 ALA A 220  GLY A 225  1  O  LEU A 223   N  PHE A 121
SHEET    8   A 8 GLU A 248  VAL A 252  1  O  VAL A 252   N  HIS A 224
SHEET    1   B 8 PHE B   2  GLU B   8  0
SHEET    2   B 8 THR B  11  HIS B  20 -1  O  LEU B  15   N  ILE B   3
SHEET    3   B 8 ARG B  52  TYR B  56 -1  O  VAL B  53   N  HIS B  20
SHEET    4   B 8 PRO B  25  ILE B  29  1  N  VAL B  26   O  ARG B  52
SHEET    5   B 8 ALA B  92  PHE B  97  1  O  VAL B  93   N  VAL B  27
SHEET    6   B 8 ILE B 116  LEU B 122  1  O  ALA B 117   N  ALA B  92
SHEET    7   B 8 ALA B 220  GLY B 225  1  O  LEU B 223   N  PHE B 121
SHEET    8   B 8 GLU B 248  VAL B 252  1  O  VAL B 252   N  HIS B 224
SHEET    1   C 8 PHE C   2  GLU C   8  0
SHEET    2   C 8 THR C  11  HIS C  20 -1  O  LEU C  15   N  ILE C   3
SHEET    3   C 8 ARG C  52  TYR C  56 -1  O  VAL C  53   N  HIS C  20
SHEET    4   C 8 PRO C  25  ILE C  29  1  N  VAL C  26   O  ARG C  52
SHEET    5   C 8 ALA C  92  PHE C  97  1  O  VAL C  93   N  VAL C  27
SHEET    6   C 8 ILE C 116  LEU C 122  1  O  ALA C 117   N  ALA C  92
SHEET    7   C 8 ALA C 220  GLY C 225  1  O  LEU C 223   N  PHE C 121
SHEET    8   C 8 GLU C 248  VAL C 252  1  O  VAL C 252   N  HIS C 224
CISPEP   1 PHE A   32    PRO A   33          0        -1.72
CISPEP   2 GLU A  126    PRO A  127          0         7.61
CISPEP   3 PHE B   32    PRO B   33          0        -1.65
CISPEP   4 GLU B  126    PRO B  127          0         6.48
CISPEP   5 PHE C   32    PRO C   33          0        -1.53
CISPEP   6 GLU C  126    PRO C  127          0         6.85
CRYST1  123.510  165.520  167.670  90.00  90.00  90.00 I 2 2 2      24
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.008097  0.000000  0.000000        0.00000
SCALE2      0.000000  0.006042  0.000000        0.00000
SCALE3      0.000000  0.000000  0.005964        0.00000
TER    3377      GLN A 441
TER    6754      GLN B 441
TER   10131      GLN C 441
MASTER      393    0    0   66   24    0    0    610128    3    0  108
END