longtext: 5A71-pdb

content
HEADER    HYDROLASE                               02-JUL-15   5A71
TITLE     OPEN AND CLOSED CONFORMATIONS AND PROTONATION STATES OF
TITLE    2 CANDIDA ANTARCTICA LIPASE B: ATOMIC RESOLUTION NATIVE
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: LIPASE B;
COMPND   3 CHAIN: A, B;
COMPND   4 FRAGMENT: RESIDUES 26-342;
COMPND   5 SYNONYM: CALB, CANDIDA ANTARCTICA LIPASE B;
COMPND   6 EC: 3.1.1.3;
COMPND   7 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: PSEUDOZYMA ANTARCTICA;
SOURCE   3 ORGANISM_TAXID: 84753;
SOURCE   4 EXPRESSION_SYSTEM: ASPERGILLUS ORYZAE;
SOURCE   5 EXPRESSION_SYSTEM_TAXID: 5062
KEYWDS    HYDROLASE, LIPASE, CANDIDA ANTARCTICA, ATOMIC RESOLUTION, FREE FATTY
KEYWDS   2 ACIDS, LIPIDS, HYDROLASE FOLD, INTERFACIAL ACTIVATION
EXPDTA    X-RAY DIFFRACTION
AUTHOR    B.STAUCH,S.J.FISHER,M.CIANCI
REVDAT   1   21-OCT-15 5A71    0
JRNL        AUTH   B.STAUCH,S.J.FISHER,M.CIANCI
JRNL        TITL   OPEN AND CLOSED STATES OF CANDIDA ANTARCTICA LIPASE B:
JRNL        TITL 2 PROTONATION AND THE MECHANISM OF INTERFACIAL ACTIVATION.
JRNL        REF    J.LIPID RES.                               2015
JRNL        REFN                   ESSN 0022-2275
JRNL        PMID   26447231
JRNL        DOI    10.1194/JLR.M063388
REMARK   2
REMARK   2 RESOLUTION.    0.91 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.8.0123
REMARK   3   AUTHORS     : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,
REMARK   3                 STEINER,NICHOLLS,WINN,LONG,VAGIN
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 0.91
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 71.04
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NONE
REMARK   3   COMPLETENESS FOR RANGE        (%) : 94.48
REMARK   3   NUMBER OF REFLECTIONS             : 326301
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.11255
REMARK   3   R VALUE            (WORKING SET) : 0.11150
REMARK   3   FREE R VALUE                     : 0.13197
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.1
REMARK   3   FREE R VALUE TEST SET COUNT      : 17383
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 0.910
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 0.934
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 19765
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 77.27
REMARK   3   BIN R VALUE           (WORKING SET) : 0.268
REMARK   3   BIN FREE R VALUE SET COUNT          : 1080
REMARK   3   BIN FREE R VALUE                    : 0.277
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 4824
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 105
REMARK   3   SOLVENT ATOMS            : 1019
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 11.793
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -0.04
REMARK   3    B22 (A**2) : 0.40
REMARK   3    B33 (A**2) : -0.29
REMARK   3    B12 (A**2) : -0.23
REMARK   3    B13 (A**2) : -0.10
REMARK   3    B23 (A**2) : 0.16
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.016
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.017
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.014
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 0.572
REMARK   3
REMARK   3  CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.987
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.983
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  5074 ; 0.026 ; 0.020
REMARK   3   BOND LENGTHS OTHERS               (A):  4781 ; 0.002 ; 0.020
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES):  7009 ; 2.257 ; 1.991
REMARK   3   BOND ANGLES OTHERS          (DEGREES): 11078 ; 1.454 ; 3.001
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):   687 ; 6.583 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   169 ;33.317 ;25.030
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):   726 ;11.303 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    17 ;20.037 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):   838 ; 0.159 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  5839 ; 0.013 ; 0.021
REMARK   3   GENERAL PLANES OTHERS             (A):  1062 ; 0.009 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  2643 ; 1.324 ; 0.914
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  2642 ; 1.321 ; 0.913
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  3325 ; 1.565 ; 1.379
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  2431 ; 2.177 ; 1.073
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ANISOTROPIC THERMAL FACTOR RESTRAINTS.   COUNT   RMS    WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  9855 ; 6.779 ; 3.000
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):   123 ;35.794 ; 5.000
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2): 10613 ;11.239 ;
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE
REMARK   3   RIDING POSITIONS.
REMARK   3  U VALUES REFINED INDIVIDUALLY
REMARK   4
REMARK   4 5A71 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 02-JUL-15.
REMARK 100 THE PDBE ID CODE IS EBI-64247.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 21-MAR-13
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 4.8
REMARK 200  NUMBER OF CRYSTALS USED        : 4
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : PETRA III
REMARK 200  BEAMLINE                       : P13 (MX1)
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.826
REMARK 200  MONOCHROMATOR                  : SI(III)
REMARK 200  OPTICS                         : KB MIRRORS
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL (PILATUS 6M)
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : AIMLESS
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 343684
REMARK 200  RESOLUTION RANGE HIGH      (A) : 0.91
REMARK 200  RESOLUTION RANGE LOW       (A) : 71.04
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 1.5
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 94.5
REMARK 200  DATA REDUNDANCY                : 17.2
REMARK 200  R MERGE                    (I) : 0.11
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 13.65
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 0.91
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 0.93
REMARK 200  COMPLETENESS FOR SHELL     (%) : 77.4
REMARK 200  DATA REDUNDANCY IN SHELL       : 3.5
REMARK 200  R MERGE FOR SHELL          (I) : 0.57
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 1.59
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: MOLREP
REMARK 200 STARTING MODEL: PDB ENTRY 1TCA
REMARK 200
REMARK 200 REMARK: NONE
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 38
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 1.98
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: CANDIDA ANTARCTICA LIPASE B
REMARK 280  (CALB) WAS PURCHASED BY HAMPTON RESEARCH AND CRYSTALLIZED
REMARK 280  WITHOUT FURTHER PURIFICATION. CRYSTALLIZATION TRIALS WERE
REMARK 280  PERFORMED AT 293 K USING THE HANGING-DROP METHOD USING A
REMARK 280  QUIAGEN EASYXTAL 15-WELL PLATE. 1 UL OF A 15 MG/ML CALB
REMARK 280  SOLUTION IN 20MM NA(CH3COO) PH = 4.8 WAS DILUTED WITH 1 UL
REMARK 280  OF THE PRECIPITANT SOLUTION, MADE OF 200MM NA(CH3COO) PH =
REMARK 280  4.8, 20% (W/V) PEG4000, AND 10-13% (V/V) 2-PROPANOL. THE
REMARK 280  DROP WAS EQUILIBRATED BY VAPOR DIFFUSION AGAINST 500 ML OF
REMARK 280  THE PRECIPITANT SOLUTION. PROTEIN CRYSTALS OF NATIVE CALB
REMARK 280  APPEARED WITHIN ONE WEEK AND GREW TO A SIZE OF 0.2 X 0.4 X
REMARK 280  0.5 MM3 IN THREE WEEKS.
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 4260 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 22840 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -34.7 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     PRO A   317
REMARK 465     PRO B   317
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   OG   SER A    28     O    HOH A  2097              2.04
REMARK 500   OD1B ASN A    74     O    HOH A  2189              2.14
REMARK 500   O    GLY A    95     O    HOH A  2243              2.10
REMARK 500   OG1A THR A   159     O    HOH A  2332              2.15
REMARK 500   OD1B ASN B    97     O    HOH B  2212              2.03
REMARK 500   OG B SER B   105     O    HOH B  2111              2.06
REMARK 500   O    PRO B   218     O    HOH B  2344              2.13
REMARK 500   NH2  ARG B   309     O    HOH B  2465              1.87
REMARK 500   O    HOH A  2107     O    HOH A  2166              2.10
REMARK 500   O    HOH A  2148     O    HOH A  2161              2.00
REMARK 500   O    HOH A  2167     O    HOH A  2174              1.80
REMARK 500   O    HOH A  2198     O    HOH A  2373              2.15
REMARK 500   O    HOH A  2213     O    HOH A  2214              2.10
REMARK 500   O    HOH A  2301     O    HOH A  2302              2.04
REMARK 500   O    HOH A  2322     O    HOH A  2324              1.94
REMARK 500   O    HOH B  2036     O    HOH B  2083              2.04
REMARK 500   O    HOH B  2062     O    HOH B  2119              1.87
REMARK 500   O    HOH B  2062     O    HOH B  2481              2.20
REMARK 500   O    HOH B  2215     O    HOH B  2404              1.88
REMARK 500   O    HOH B  2225     O    HOH B  2413              2.15
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS
REMARK 500
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.
REMARK 500
REMARK 500 DISTANCE CUTOFF:
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE
REMARK 500   NH1  ARG B   309     O    HOH B  2390     2665     1.94
REMARK 500  NA     NA B  1325     O    HOH A  2462     2665     1.85
REMARK 500  NA     NA B  1325     O    HOH A  2419     2665     1.81
REMARK 500   O    HOH A  2055     O    HOH A  2434     2655     2.15
REMARK 500   O    HOH A  2065     O    HOH A  2444     2655     1.79
REMARK 500   O    HOH A  2071     O    HOH A  2442     2655     1.92
REMARK 500   O    HOH A  2072     O    HOH A  2393     2655     2.19
REMARK 500   O    HOH A  2305     O    HOH B  2372     2554     2.13
REMARK 500   O    HOH B  2022     O    HOH B  2385     2565     2.01
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION
REMARK 500    LYS A  32   CD    LYS A  32   CE      0.157
REMARK 500    GLY A  95   N     GLY A  95   CA      0.114
REMARK 500    ASN A  96   CA    ASN A  96   C      -0.162
REMARK 500    LYS A 124   CE    LYS A 124   NZ     -0.163
REMARK 500    GLY B   4   N     GLY B   4   CA      0.103
REMARK 500    SER B  28   CA    SER B  28   CB      0.110
REMARK 500    SER B 123   CA    SER B 123   CB      0.102
REMARK 500    SER B 123   CB    SER B 123   OG      0.095
REMARK 500    SER B 150   CB    SER B 150   OG     -0.081
REMARK 500    ARG B 238   CZ    ARG B 238   NH2    -0.100
REMARK 500    ARG B 242   CZ A  ARG B 242   NH1A   -0.106
REMARK 500    ARG B 242   CZ A  ARG B 242   NH2A   -0.129
REMARK 500    GLU B 269   CD    GLU B 269   OE1     0.077
REMARK 500    GLU B 269   CD    GLU B 269   OE2     0.093
REMARK 500    GLU B 269   CG    GLU B 269   CD      0.102
REMARK 500    LEU B 277   CB    LEU B 277   CG     -0.183
REMARK 500    GLU B 294   CD    GLU B 294   OE1    -0.070
REMARK 500    ARG B 309   CZ    ARG B 309   NH2     0.088
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    MET A  83   CG  -  SD  -  CE  ANGL. DEV. = -15.9 DEGREES
REMARK 500    ASP A 134   CB  -  CG  -  OD1 ANGL. DEV. =   6.1 DEGREES
REMARK 500    ASP A 134   CB  -  CG  -  OD2 ANGL. DEV. =  -6.0 DEGREES
REMARK 500    VAL A 139   CA  -  CB  -  CG2 ANGL. DEV. =   9.9 DEGREES
REMARK 500    ASP A 145   CB  -  CG  -  OD1 ANGL. DEV. =   6.8 DEGREES
REMARK 500    ASP A 145   CB  -  CG  -  OD2 ANGL. DEV. =  -8.7 DEGREES
REMARK 500    ARG A 168   NE  -  CZ  -  NH1 ANGL. DEV. =   3.7 DEGREES
REMARK 500    ARG A 168   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.7 DEGREES
REMARK 500    ARG A 249   NE  -  CZ  -  NH1 ANGL. DEV. =   4.6 DEGREES
REMARK 500    ARG A 249   NE  -  CZ  -  NH2 ANGL. DEV. =  -6.0 DEGREES
REMARK 500    LEU A 278   CB  -  CG  -  CD1 ANGL. DEV. = -11.2 DEGREES
REMARK 500    ARG A 302   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.6 DEGREES
REMARK 500    LEU B   1   CA  -  CB  -  CG  ANGL. DEV. =  19.2 DEGREES
REMARK 500    ASP B 134   CB  -  CG  -  OD1 ANGL. DEV. =   6.9 DEGREES
REMARK 500    ASP B 134   CB  -  CG  -  OD2 ANGL. DEV. =  -7.5 DEGREES
REMARK 500    ARG B 238   NE  -  CZ  -  NH2 ANGL. DEV. =   3.3 DEGREES
REMARK 500    ARG B 242   NE  -  CZ  -  NH2 ANGL. DEV. =   5.8 DEGREES
REMARK 500    ARG B 242   NH1 -  CZ  -  NH2 ANGL. DEV. =  -8.0 DEGREES
REMARK 500    LEU B 277   CB  -  CG  -  CD1 ANGL. DEV. = -11.0 DEGREES
REMARK 500    ARG B 302   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.9 DEGREES
REMARK 500    CYS B 311   CB  -  CA  -  C   ANGL. DEV. =  -7.3 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    SER A   3       20.77   -146.03
REMARK 500    SER A  29       87.07   -156.88
REMARK 500    ASN A  51      -96.65   -149.77
REMARK 500    ASP A  75      118.98    -32.43
REMARK 500    SER A 105     -133.68     59.74
REMARK 500    ASP A 134       66.15   -113.53
REMARK 500    ALA A 305       38.19   -142.84
REMARK 500    SER B  29       82.84   -156.37
REMARK 500    ASN B  51      -96.77   -149.21
REMARK 500    ASP B  75      120.17    -30.64
REMARK 500    SER B 105     -130.71     59.60
REMARK 500    ASP B 134       65.66   -111.69
REMARK 500    ASN B 206       -0.76     71.38
REMARK 500    ALA B 305       33.79   -140.19
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY
REMARK 500
REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY
REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER
REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME;
REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 500 I=INSERTION CODE).
REMARK 500
REMARK 500  M RES CSSEQI        ANGLE
REMARK 500    ILE A 285         10.13
REMARK 500
REMARK 500 REMARK: NULL
REMARK 620
REMARK 620 METAL COORDINATION
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                               K A1320   K
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 HOH A2298   O
REMARK 620 2 HOH A2230   O   128.4
REMARK 620 3 ASP A 252   OD1 126.0 105.5
REMARK 620 N                    1     2
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                               K A1321   K
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 SER A  29   OG
REMARK 620 2 ASN B  96   OD1 107.1
REMARK 620 3 HOH A2099   O   129.3  98.9
REMARK 620 4 HOH A2100   O    50.4  64.7 109.9
REMARK 620 5 HOH A2106   O    88.1 108.8 123.6 126.2
REMARK 620 6 SER A  29   O    59.6 153.6  77.9  91.4  94.2
REMARK 620 N                    1     2     3     4     5
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                               K B1321   K
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 HOH B2376   O
REMARK 620 2 ASN B 206   O   113.1
REMARK 620 3 HOH B2298   O   134.0  59.6
REMARK 620 N                    1     2
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                               K A1322   K
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 LEU A  20   O
REMARK 620 2 HOH A2062   O    93.1
REMARK 620 3 ASP A  17   O    74.3  67.3
REMARK 620 4 HOH A2061   O   136.2  96.9  70.8
REMARK 620 N                    1     2     3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              NA A1323  NA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 PHE A 220   O
REMARK 620 2 HOH A2404   O   142.4
REMARK 620 3 HOH A2405   O   117.2  94.5
REMARK 620 N                    1     2
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              NA B1323  NA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 GLU B 294   OE1
REMARK 620 2 HOH B2284   O   109.5
REMARK 620 3 ARG B 309   O   107.9 101.9
REMARK 620 N                    1     2
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              NA B1324  NA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 GLN B  46   OE1
REMARK 620 2 GLY B  41   O    98.8
REMARK 620 3 HOH B2120   O    81.0 103.1
REMARK 620 4 HOH B2432   O   125.8 122.9  58.6
REMARK 620 5 HOH B2481   O   117.8 130.9 113.4  60.0
REMARK 620 N                    1     2     3     4
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              NA B1325  NA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 HOH A2494   O
REMARK 620 2 HOH A2420   O    89.4
REMARK 620 N                    1
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE IPA A1319
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE IPA B1319
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE IPA B1320
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE   K A1320
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE   K A1321
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE   K A1322
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE   K B1321
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE  NA B1322
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE  NA B1323
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE  NA B1324
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE  NA A1323
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE  NA B1325
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR POLY-SACCHARIDE
REMARK 800  RESIDUES NAG A1317  THROUGH NAG A1318  BOUND TO ASN A  74
REMARK 800
REMARK 800 SITE_IDENTIFIER: BC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR POLY-SACCHARIDE
REMARK 800  RESIDUES NAG B1317  THROUGH NAG B1318  BOUND TO ASN B  74
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 5A6V   RELATED DB: PDB
REMARK 900  OPEN AND CLOSED CONFORMATIONS AND PROTONATION STATES OF
REMARK 900   CANDIDA ANTARCTICA LIPASE B: XENON COMPLEX
DBREF  5A71 A    1   317  UNP    P41365   LIPB_CANAR      26    342
DBREF  5A71 B    1   317  UNP    P41365   LIPB_CANAR      26    342
SEQRES   1 A  317  LEU PRO SER GLY SER ASP PRO ALA PHE SER GLN PRO LYS
SEQRES   2 A  317  SER VAL LEU ASP ALA GLY LEU THR CYS GLN GLY ALA SER
SEQRES   3 A  317  PRO SER SER VAL SER LYS PRO ILE LEU LEU VAL PRO GLY
SEQRES   4 A  317  THR GLY THR THR GLY PRO GLN SER PHE ASP SER ASN TRP
SEQRES   5 A  317  ILE PRO LEU SER THR GLN LEU GLY TYR THR PRO CYS TRP
SEQRES   6 A  317  ILE SER PRO PRO PRO PHE MET LEU ASN ASP THR GLN VAL
SEQRES   7 A  317  ASN THR GLU TYR MET VAL ASN ALA ILE THR ALA LEU TYR
SEQRES   8 A  317  ALA GLY SER GLY ASN ASN LYS LEU PRO VAL LEU THR TRP
SEQRES   9 A  317  SER GLN GLY GLY LEU VAL ALA GLN TRP GLY LEU THR PHE
SEQRES  10 A  317  PHE PRO SER ILE ARG SER LYS VAL ASP ARG LEU MET ALA
SEQRES  11 A  317  PHE ALA PRO ASP TYR LYS GLY THR VAL LEU ALA GLY PRO
SEQRES  12 A  317  LEU ASP ALA LEU ALA VAL SER ALA PRO SER VAL TRP GLN
SEQRES  13 A  317  GLN THR THR GLY SER ALA LEU THR THR ALA LEU ARG ASN
SEQRES  14 A  317  ALA GLY GLY LEU THR GLN ILE VAL PRO THR THR ASN LEU
SEQRES  15 A  317  TYR SER ALA THR ASP GLU ILE VAL GLN PRO GLN VAL SER
SEQRES  16 A  317  ASN SER PRO LEU ASP SER SER TYR LEU PHE ASN GLY LYS
SEQRES  17 A  317  ASN VAL GLN ALA GLN ALA VAL CYS GLY PRO LEU PHE VAL
SEQRES  18 A  317  ILE ASP HIS ALA GLY SER LEU THR SER GLN PHE SER TYR
SEQRES  19 A  317  VAL VAL GLY ARG SER ALA LEU ARG SER THR THR GLY GLN
SEQRES  20 A  317  ALA ARG SER ALA ASP TYR GLY ILE THR ASP CYS ASN PRO
SEQRES  21 A  317  LEU PRO ALA ASN ASP LEU THR PRO GLU GLN LYS VAL ALA
SEQRES  22 A  317  ALA ALA ALA LEU LEU ALA PRO ALA ALA ALA ALA ILE VAL
SEQRES  23 A  317  ALA GLY PRO LYS GLN ASN CYS GLU PRO ASP LEU MET PRO
SEQRES  24 A  317  TYR ALA ARG PRO PHE ALA VAL GLY LYS ARG THR CYS SER
SEQRES  25 A  317  GLY ILE VAL THR PRO
SEQRES   1 B  317  LEU PRO SER GLY SER ASP PRO ALA PHE SER GLN PRO LYS
SEQRES   2 B  317  SER VAL LEU ASP ALA GLY LEU THR CYS GLN GLY ALA SER
SEQRES   3 B  317  PRO SER SER VAL SER LYS PRO ILE LEU LEU VAL PRO GLY
SEQRES   4 B  317  THR GLY THR THR GLY PRO GLN SER PHE ASP SER ASN TRP
SEQRES   5 B  317  ILE PRO LEU SER THR GLN LEU GLY TYR THR PRO CYS TRP
SEQRES   6 B  317  ILE SER PRO PRO PRO PHE MET LEU ASN ASP THR GLN VAL
SEQRES   7 B  317  ASN THR GLU TYR MET VAL ASN ALA ILE THR ALA LEU TYR
SEQRES   8 B  317  ALA GLY SER GLY ASN ASN LYS LEU PRO VAL LEU THR TRP
SEQRES   9 B  317  SER GLN GLY GLY LEU VAL ALA GLN TRP GLY LEU THR PHE
SEQRES  10 B  317  PHE PRO SER ILE ARG SER LYS VAL ASP ARG LEU MET ALA
SEQRES  11 B  317  PHE ALA PRO ASP TYR LYS GLY THR VAL LEU ALA GLY PRO
SEQRES  12 B  317  LEU ASP ALA LEU ALA VAL SER ALA PRO SER VAL TRP GLN
SEQRES  13 B  317  GLN THR THR GLY SER ALA LEU THR THR ALA LEU ARG ASN
SEQRES  14 B  317  ALA GLY GLY LEU THR GLN ILE VAL PRO THR THR ASN LEU
SEQRES  15 B  317  TYR SER ALA THR ASP GLU ILE VAL GLN PRO GLN VAL SER
SEQRES  16 B  317  ASN SER PRO LEU ASP SER SER TYR LEU PHE ASN GLY LYS
SEQRES  17 B  317  ASN VAL GLN ALA GLN ALA VAL CYS GLY PRO LEU PHE VAL
SEQRES  18 B  317  ILE ASP HIS ALA GLY SER LEU THR SER GLN PHE SER TYR
SEQRES  19 B  317  VAL VAL GLY ARG SER ALA LEU ARG SER THR THR GLY GLN
SEQRES  20 B  317  ALA ARG SER ALA ASP TYR GLY ILE THR ASP CYS ASN PRO
SEQRES  21 B  317  LEU PRO ALA ASN ASP LEU THR PRO GLU GLN LYS VAL ALA
SEQRES  22 B  317  ALA ALA ALA LEU LEU ALA PRO ALA ALA ALA ALA ILE VAL
SEQRES  23 B  317  ALA GLY PRO LYS GLN ASN CYS GLU PRO ASP LEU MET PRO
SEQRES  24 B  317  TYR ALA ARG PRO PHE ALA VAL GLY LYS ARG THR CYS SER
SEQRES  25 B  317  GLY ILE VAL THR PRO
HET    NAG  A1317      28
HET    NAG  A1318      28
HET    IPA  A1319       4
HET    NAG  B1317      14
HET    NAG  B1318      14
HET    IPA  B1319       4
HET    IPA  B1320       4
HET      K  A1320       1
HET      K  A1321       1
HET      K  A1322       1
HET      K  B1321       1
HET     NA  B1322       1
HET     NA  B1323       1
HET     NA  B1324       1
HET     NA  A1323       1
HET     NA  B1325       1
HETNAM     IPA ISOPROPYL ALCOHOL
HETNAM       K POTASSIUM ION
HETNAM      NA SODIUM ION
HETNAM     NAG N-ACETYL-D-GLUCOSAMINE
HETSYN     IPA 2-PROPANOL
FORMUL   3  IPA    3(C3 H8 O)
FORMUL   4   NA    5(NA 1+)
FORMUL   5  NAG    4(C8 H15 N O6)
FORMUL   6    K    4(K 1+)
FORMUL   7  HOH   *1019(H2 O)
HELIX    1   1 PRO A   12  GLY A   19  1                                   8
HELIX    2   2 THR A   43  ASP A   49  1                                   7
HELIX    3   3 ASN A   51  LEU A   59  1                                   9
HELIX    4   4 ASP A   75  SER A   94  1                                  20
HELIX    5   5 SER A  105  PHE A  118  1                                  14
HELIX    6   6 PRO A  119  ARG A  122  5                                   4
HELIX    7   7 ALA A  141  LEU A  147  1                                   7
HELIX    8   8 ALA A  151  GLN A  157  1                                   7
HELIX    9   9 SER A  161  ALA A  170  1                                  10
HELIX   10  10 ALA A  212  GLY A  217  1                                   6
HELIX   11  11 ALA A  225  SER A  230  1                                   6
HELIX   12  12 SER A  230  SER A  243  1                                  14
HELIX   13  13 ARG A  249  TYR A  253  5                                   5
HELIX   14  14 GLY A  254  CYS A  258  5                                   5
HELIX   15  15 THR A  267  ALA A  276  1                                  10
HELIX   16  16 LEU A  277  GLY A  288  1                                  12
HELIX   17  17 ALA A  301  ALA A  305  5                                   5
HELIX   18  18 PRO B   12  GLY B   19  1                                   8
HELIX   19  19 THR B   43  ASP B   49  1                                   7
HELIX   20  20 ASN B   51  LEU B   59  1                                   9
HELIX   21  21 ASP B   75  SER B   94  1                                  20
HELIX   22  22 SER B  105  PHE B  118  1                                  14
HELIX   23  23 PRO B  119  SER B  123  5                                   5
HELIX   24  24 ALA B  151  GLN B  157  1                                   7
HELIX   25  25 SER B  161  ALA B  170  1                                  10
HELIX   26  26 ALA B  212  GLY B  217  1                                   6
HELIX   27  27 ALA B  225  SER B  230  1                                   6
HELIX   28  28 SER B  230  SER B  243  1                                  14
HELIX   29  29 ARG B  249  TYR B  253  5                                   5
HELIX   30  30 GLY B  254  CYS B  258  5                                   5
HELIX   31  31 THR B  267  ALA B  276  1                                  10
HELIX   32  32 LEU B  277  GLY B  288  1                                  12
HELIX   33  33 ALA B  301  ALA B  305  5                                   5
SHEET    1  AA 7 LEU A  20  CYS A  22  0
SHEET    2  AA 7 THR A  62  ILE A  66 -1  O  TRP A  65   N  THR A  21
SHEET    3  AA 7 PRO A  33  VAL A  37  1  O  ILE A  34   N  CYS A  64
SHEET    4  AA 7 LEU A  99  TRP A 104  1  O  PRO A 100   N  LEU A  35
SHEET    5  AA 7 VAL A 125  PHE A 131  1  N  ASP A 126   O  LEU A  99
SHEET    6  AA 7 THR A 179  TYR A 183  1  O  THR A 180   N  ALA A 130
SHEET    7  AA 7 LYS A 208  GLN A 211  1  O  LYS A 208   N  ASN A 181
SHEET    1  AB 2 ARG A 309  THR A 310  0
SHEET    2  AB 2 GLY A 313  ILE A 314 -1  O  GLY A 313   N  THR A 310
SHEET    1  BA 7 LEU B  20  CYS B  22  0
SHEET    2  BA 7 THR B  62  ILE B  66 -1  O  TRP B  65   N  THR B  21
SHEET    3  BA 7 PRO B  33  VAL B  37  1  O  ILE B  34   N  CYS B  64
SHEET    4  BA 7 LEU B  99  TRP B 104  1  O  PRO B 100   N  LEU B  35
SHEET    5  BA 7 VAL B 125  PHE B 131  1  N  ASP B 126   O  LEU B  99
SHEET    6  BA 7 THR B 179  TYR B 183  1  O  THR B 180   N  ALA B 130
SHEET    7  BA 7 LYS B 208  GLN B 211  1  O  LYS B 208   N  ASN B 181
SHEET    1  BB 2 ARG B 309  THR B 310  0
SHEET    2  BB 2 GLY B 313  ILE B 314 -1  O  GLY B 313   N  THR B 310
SSBOND   1 CYS A   22    CYS A   64                          1555   1555  2.07
SSBOND   2 CYS A  216    CYS A  258                          1555   1555  2.05
SSBOND   3 CYS A  293    CYS A  311                          1555   1555  2.04
SSBOND   4 CYS B   22    CYS B   64                          1555   1555  2.07
SSBOND   5 CYS B  216    CYS B  258                          1555   1555  2.05
SSBOND   6 CYS B  293    CYS B  311                          1555   1555  2.04
LINK         ND2AASN A  74                 C1 ANAG A1317     1555   1555  1.46
LINK         ND2BASN A  74                 C1 BNAG A1317     1555   1555  1.47
LINK         O   PRO A 218                NA    NA A1323     1555   1555  1.77
LINK         O4 ANAG A1317                 C1 ANAG A1318     1555   1555  1.38
LINK         O4 BNAG A1317                 C1 BNAG A1318     1555   1555  1.39
LINK         K     K A1320                 O   HOH A2230     1555   1555  3.07
LINK         K     K A1320                 OD1 ASP A 252     1555   1555  2.79
LINK         K     K A1320                 O   HOH A2298     1555   1445  2.45
LINK         K     K A1321                 O   SER A  29     1555   1555  3.18
LINK         K     K A1321                 O   HOH A2100     1555   1555  2.55
LINK         K     K A1321                 O   HOH A2106     1555   1555  2.63
LINK         K     K A1321                 OG  SER A  29     1555   1555  3.34
LINK         K     K A1321                 O   HOH A2099     1555   1555  2.37
LINK         K     K A1321                 OD1 ASN B  96     1555   1544  3.04
LINK         K     K A1322                 O   ASP A  17     1555   1555  2.92
LINK         K     K A1322                 O   HOH A2061     1555   1555  3.04
LINK         K     K A1322                 O   LEU A  20     1555   1555  2.75
LINK         K     K A1322                 O   HOH A2062     1555   1555  2.55
LINK        NA    NA A1323                 O   HOH A2405     1555   1555  2.62
LINK        NA    NA A1323                 O   HOH A2404     1555   1555  2.49
LINK        NA    NA A1323                 O   PHE A 220     1555   1555  2.82
LINK         ND2 ASN B  74                 C1  NAG B1317     1555   1555  1.52
LINK         O4  NAG B1317                 C1  NAG B1318     1555   1555  1.38
LINK         K     K B1321                 O   ASN B 206     1555   1555  2.97
LINK         K     K B1321                 O   HOH B2376     1555   1555  2.52
LINK         K     K B1321                 O   HOH B2298     1555   1555  2.70
LINK        NA    NA B1322                 O   HOH B2418     1555   1555  2.75
LINK        NA    NA B1323                 O   ARG B 309     1555   1555  2.34
LINK        NA    NA B1323                 O   HOH B2284     1555   1555  2.49
LINK        NA    NA B1323                 OE1 GLU B 294     1555   1555  2.58
LINK        NA    NA B1324                 O   HOH B2481     1555   1555  3.10
LINK        NA    NA B1324                 O   HOH B2432     1555   1555  2.27
LINK        NA    NA B1324                 O   HOH B2120     1555   1555  2.96
LINK        NA    NA B1324                 O   GLY B  41     1555   1555  2.78
LINK        NA    NA B1324                 OE1 GLN B  46     1555   1555  2.69
LINK        NA    NA B1325                 O   HOH A2420     1555   1665  2.75
LINK        NA    NA B1325                 O   HOH A2494     1555   1555  2.77
CISPEP   1 PRO A   69    PRO A   70          0       -14.76
CISPEP   2 GLN A  191    PRO A  192          0         8.71
CISPEP   3 PRO B   69    PRO B   70          0       -10.53
CISPEP   4 GLN B  191    PRO B  192          0        -0.23
SITE     1 AC1  6 THR A  40  SER A 105  ASP A 134  GLN A 157
SITE     2 AC1  6 ILE A 189  HOH A2281
SITE     1 AC2  5 THR B  40  ALA B 282  ILE B 285  IPA B1320
SITE     2 AC2  5 HOH B2111
SITE     1 AC3  5 THR B  40  GLN B 157  IPA B1319  HOH B2276
SITE     2 AC3  5 HOH B2480
SITE     1 AC4  4 ASP A 252  THR A 316  HOH A2230  HOH A2298
SITE     1 AC5  5 SER A  29  HOH A2099  HOH A2100  HOH A2106
SITE     2 AC5  5 ASN B  96
SITE     1 AC6  4 ASP A  17  LEU A  20  HOH A2061  HOH A2062
SITE     1 AC7  4 ASN B 206  GLN B 247  HOH B2298  HOH B2376
SITE     1 AC8  2 THR B 267  HOH B2418
SITE     1 AC9  3 GLU B 294  ARG B 309  HOH B2284
SITE     1 BC1  7 GLY B  41  GLN B  46  PHE B  71  ALA B 284
SITE     2 BC1  7 HOH B2120  HOH B2432  HOH B2481
SITE     1 BC2  6 GLN A 213  PRO A 218  LEU A 219  PHE A 220
SITE     2 BC2  6 HOH A2404  HOH A2405
SITE     1 BC3  6 ASP A 265  ASN A 292  HOH A2419  HOH A2420
SITE     2 BC3  6 HOH A2462  HOH A2494
SITE     1 BC4 12 SER A  10  GLN A  11  ASN A  74  ASP A  75
SITE     2 BC4 12 VAL A  78  HOH A2039  HOH A2040  HOH A2046
SITE     3 BC4 12 HOH A2047  HOH A2179  HOH A2530  HOH A2531
SITE     1 BC5 10 SER B  10  GLN B  11  ASN B  74  ASP B  75
SITE     2 BC5 10 VAL B  78  HOH B2038  HOH B2164  HOH B2184
SITE     3 BC5 10 HOH B2473  HOH B2474
CRYST1   39.670   48.940   71.610  88.74  97.15 108.44 P 1           2
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.025208  0.008405  0.003318        0.00000
SCALE2      0.000000  0.021539  0.000398        0.00000
SCALE3      0.000000  0.000000  0.014076        0.00000
TER    2418      THR A 316
TER    4826      THR B 316
MASTER      555    0   16   33   18    0   25    6 5948    2  151   50
END