longtext: 5AJH-pdb

content
HEADER    HYDROLASE                               24-FEB-15   5AJH
TITLE     CRYSTAL STRUCTURE OF FUSARIUM OXYSPORUM CUTINASE
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: CUTINASE;
COMPND   3 CHAIN: A, B, C;
COMPND   4 FRAGMENT: UNP RESIDUES 17-230;
COMPND   5 EC: 3.1.1.74;
COMPND   6 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: FUSARIUM OXYSPORUM F. SP. RAPHANI;
SOURCE   3 ORGANISM_TAXID: 1089458;
SOURCE   4 STRAIN: PHW815;
SOURCE   5 ATCC: NRRL 54005;
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PET22B
KEYWDS    HYDROLASE, ALPHA/BETA HYDROLASE FOLD, ESTERASE, PET MODIFICATION
EXPDTA    X-RAY DIFFRACTION
AUTHOR    M.DIMAROGONA,E.NIKOLAIVITS,M.KANELLI,P.CHRISTAKOPOULOS,M.SANDGREN,
AUTHOR   2 E.TOPAKAS
REVDAT   1   02-SEP-15 5AJH    0
JRNL        AUTH   M.DIMAROGONA,E.NIKOLAIVITS,M.KANELLI,P.CHRISTAKOPOULOS,
JRNL        AUTH 2 M.SANDGREN,E.TOPAKAS
JRNL        TITL   STRUCTURAL AND FUNCTIONAL STUDIES OF A FUSARIUM OXYSPORUM
JRNL        TITL 2 CUTINASE WITH POLYETHYLENE TEREPHTHALATE MODIFICATION
JRNL        TITL 3 POTENTIAL.
JRNL        REF    BIOCHIM.BIOPHYS.ACTA                       2015
JRNL        REFN                   ESSN 0006-3002
JRNL        PMID   26291558
JRNL        DOI    10.1016/J.BBAGEN.2015.08.009
REMARK   2
REMARK   2 RESOLUTION.    1.90 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.8.0073
REMARK   3   AUTHORS     : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,
REMARK   3                 STEINER,NICHOLLS,WINN,LONG,VAGIN
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.90
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 120.98
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NONE
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.70
REMARK   3   NUMBER OF REFLECTIONS             : 40392
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.18355
REMARK   3   R VALUE            (WORKING SET) : 0.18143
REMARK   3   FREE R VALUE                     : 0.22373
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.9
REMARK   3   FREE R VALUE TEST SET COUNT      : 2067
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 1.900
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 1.949
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 2913
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 99.97
REMARK   3   BIN R VALUE           (WORKING SET) : 0.284
REMARK   3   BIN FREE R VALUE SET COUNT          : 164
REMARK   3   BIN FREE R VALUE                    : 0.312
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 4246
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 48
REMARK   3   SOLVENT ATOMS            : 468
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 19.117
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -0.09
REMARK   3    B22 (A**2) : -0.73
REMARK   3    B33 (A**2) : 0.81
REMARK   3    B12 (A**2) : 0.00
REMARK   3    B13 (A**2) : 0.00
REMARK   3    B23 (A**2) : 0.00
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.166
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.149
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.122
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 4.337
REMARK   3
REMARK   3  CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.951
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.924
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  4368 ; 0.008 ; 0.019
REMARK   3   BOND LENGTHS OTHERS               (A):  4168 ; 0.001 ; 0.020
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES):  5937 ; 1.212 ; 1.969
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  9558 ; 0.774 ; 3.000
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):   603 ; 4.982 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   156 ;40.111 ;24.295
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):   641 ;13.595 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    23 ;17.787 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):   674 ; 0.065 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  5133 ; 0.005 ; 0.021
REMARK   3   GENERAL PLANES OTHERS             (A):   957 ; 0.001 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  2403 ; 0.875 ; 1.817
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  2402 ; 0.874 ; 1.817
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  3006 ; 1.445 ; 2.720
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  1965 ; 1.029 ; 1.915
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ANISOTROPIC THERMAL FACTOR RESTRAINTS.   COUNT   RMS    WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE
REMARK   3   RIDING POSITIONS.
REMARK   3   SIDE CHAINS OF RESIDUES 79, 97, 108, 157, 165 IN CHAIN A,
REMARK   3    79 AND 97 IN CHAIN B, AND 31, 66, 67, 82, 159, 165, 206
REMARK   3    IN CHAIN C, HAVE BEEN TRIMMED DUE TO INSUFFICIENT
REMARK   3    ELECTRON DENSITY
REMARK   4
REMARK   4 5AJH COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 24-FEB-15.
REMARK 100 THE PDBE ID CODE IS EBI-63056.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 17-JUL-14
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 8.5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : ESRF
REMARK 200  BEAMLINE                       : ID23-2
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.8726
REMARK 200  MONOCHROMATOR                  : SI(111)
REMARK 200  OPTICS                         : MIRRORS
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD (MARMOSAIC 225)
REMARK 200  DETECTOR MANUFACTURER          : MARRESEARCH
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : AIMLESS
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 42540
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.90
REMARK 200  RESOLUTION RANGE LOW       (A) : 120.90
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 1.5
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.8
REMARK 200  DATA REDUNDANCY                : 8.6
REMARK 200  R MERGE                    (I) : 0.23
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 7.50
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.90
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.94
REMARK 200  COMPLETENESS FOR SHELL     (%) : 100.0
REMARK 200  DATA REDUNDANCY IN SHELL       : 8.5
REMARK 200  R MERGE FOR SHELL          (I) : 1.27
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 1.50
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: PDB ENTRY 1CEX
REMARK 200
REMARK 200 REMARK: NONE
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 35.07
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 1.89
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.12M MONOSACCHARIDES, PH 8.5
REMARK 280  12.5% MPD, 12.5% PEG1000, 12.5% PEG3350
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X+1/2,-Y,Z+1/2
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       17.95300
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000      120.98250
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       30.07050
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000      120.98250
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       17.95300
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       30.07050
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 3
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A     0
REMARK 465     LEU A     1
REMARK 465     PRO A     2
REMARK 465     ALA A     3
REMARK 465     GLY A     4
REMARK 465     GLN A     5
REMARK 465     ASP A     6
REMARK 465     ALA A     7
REMARK 465     ALA A     8
REMARK 465     ALA A     9
REMARK 465     LEU A    10
REMARK 465     GLU A    11
REMARK 465     ALA A    12
REMARK 465     ARG A    13
REMARK 465     GLN A    14
REMARK 465     LEU A    15
REMARK 465     GLY A    16
REMARK 465     GLY A    17
REMARK 465     GLU A   219
REMARK 465     HIS A   220
REMARK 465     HIS A   221
REMARK 465     HIS A   222
REMARK 465     HIS A   223
REMARK 465     HIS A   224
REMARK 465     HIS A   225
REMARK 465     MET B     0
REMARK 465     LEU B     1
REMARK 465     PRO B     2
REMARK 465     ALA B     3
REMARK 465     GLY B     4
REMARK 465     GLN B     5
REMARK 465     ASP B     6
REMARK 465     ALA B     7
REMARK 465     ALA B     8
REMARK 465     ALA B     9
REMARK 465     LEU B    10
REMARK 465     GLU B    11
REMARK 465     ALA B    12
REMARK 465     ARG B    13
REMARK 465     GLN B    14
REMARK 465     LEU B    15
REMARK 465     GLY B    16
REMARK 465     GLY B    17
REMARK 465     ALA B   217
REMARK 465     LEU B   218
REMARK 465     GLU B   219
REMARK 465     HIS B   220
REMARK 465     HIS B   221
REMARK 465     HIS B   222
REMARK 465     HIS B   223
REMARK 465     HIS B   224
REMARK 465     HIS B   225
REMARK 465     MET C     0
REMARK 465     LEU C     1
REMARK 465     PRO C     2
REMARK 465     ALA C     3
REMARK 465     GLY C     4
REMARK 465     GLN C     5
REMARK 465     ASP C     6
REMARK 465     ALA C     7
REMARK 465     ALA C     8
REMARK 465     ALA C     9
REMARK 465     LEU C    10
REMARK 465     GLU C    11
REMARK 465     ALA C    12
REMARK 465     ARG C    13
REMARK 465     GLN C    14
REMARK 465     LEU C    15
REMARK 465     GLY C    16
REMARK 465     GLY C    17
REMARK 465     ALA C   214
REMARK 465     ALA C   215
REMARK 465     ALA C   216
REMARK 465     ALA C   217
REMARK 465     LEU C   218
REMARK 465     GLU C   219
REMARK 465     HIS C   220
REMARK 465     HIS C   221
REMARK 465     HIS C   222
REMARK 465     HIS C   223
REMARK 465     HIS C   224
REMARK 465     HIS C   225
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     ARG A  79    CZ   NH1  NH2
REMARK 470     ARG A  97    CZ   NH1  NH2
REMARK 470     GLN A 108    CD   OE1  NE2
REMARK 470     ARG A 157    NE   CZ   NH1  NH2
REMARK 470     GLU A 165    CD   OE1  OE2
REMARK 470     LEU A 218    CG   CD1  CD2
REMARK 470     ARG B  79    NH1  NH2
REMARK 470     ARG B  97    CZ   NH1  NH2
REMARK 470     SER C  31    CB   OG
REMARK 470     LYS C  66    CD   CE   NZ
REMARK 470     ASN C  67    OD1  ND2
REMARK 470     LEU C  82    CD1  CD2
REMARK 470     LYS C 159    CD   CE   NZ
REMARK 470     GLU C 165    CD   OE1  OE2
REMARK 470     GLN C 206    CD   OE1  NE2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    THR A  44       -9.92     74.73
REMARK 500    SER A 121     -119.91     68.22
REMARK 500    LEU A 183       63.00   -104.94
REMARK 500    THR B  44       -9.98     77.37
REMARK 500    SER B 121     -119.72     62.61
REMARK 500    ALA B 191       56.92   -119.87
REMARK 500    SER C  29        1.03    -68.29
REMARK 500    SER C 121     -120.81     62.98
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH C2044        DISTANCE =  5.07 ANGSTROMS
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MPD A1219
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MPD A1220
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MPD A1221
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MPD B1217
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MPD B1218
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MPD B1219
REMARK 999
REMARK 999 SEQUENCE
REMARK 999 RESIDUE 145 IN ALL CHAINS OF THE DEPOSITED STRUCTURE IS AN
REMARK 999 ALANINE INSTEAD OF VALINE
DBREF  5AJH A    1   214  UNP    X0BTD8   X0BTD8_FUSOX    17    230
DBREF  5AJH B    1   214  UNP    X0BTD8   X0BTD8_FUSOX    17    230
DBREF  5AJH C    1   214  UNP    X0BTD8   X0BTD8_FUSOX    17    230
SEQADV 5AJH MET A    0  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH ALA A  215  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH ALA A  216  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH ALA A  217  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH LEU A  218  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH GLU A  219  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH HIS A  220  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH HIS A  221  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH HIS A  222  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH HIS A  223  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH HIS A  224  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH HIS A  225  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH ALA A  145  UNP  X0BTD8    VAL   161 CLONING ARTEFACT
SEQADV 5AJH MET B    0  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH ALA B  215  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH ALA B  216  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH ALA B  217  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH LEU B  218  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH GLU B  219  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH HIS B  220  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH HIS B  221  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH HIS B  222  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH HIS B  223  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH HIS B  224  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH HIS B  225  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH ALA B  145  UNP  X0BTD8    VAL   161 CLONING ARTEFACT
SEQADV 5AJH MET C    0  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH ALA C  215  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH ALA C  216  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH ALA C  217  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH LEU C  218  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH GLU C  219  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH HIS C  220  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH HIS C  221  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH HIS C  222  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH HIS C  223  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH HIS C  224  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH HIS C  225  UNP  X0BTD8              EXPRESSION TAG
SEQADV 5AJH ALA C  145  UNP  X0BTD8    VAL   161 CLONING ARTEFACT
SEQRES   1 A  226  MET LEU PRO ALA GLY GLN ASP ALA ALA ALA LEU GLU ALA
SEQRES   2 A  226  ARG GLN LEU GLY GLY SER ILE THR ARG ASN ASP LEU ALA
SEQRES   3 A  226  ASN GLY ASN SER GLY SER CYS PRO GLY VAL ILE PHE ILE
SEQRES   4 A  226  TYR ALA ARG GLY SER THR GLU SER GLY ASN LEU GLY THR
SEQRES   5 A  226  LEU GLY PRO ARG VAL ALA SER LYS LEU GLU ALA LYS TYR
SEQRES   6 A  226  GLY LYS ASN GLY VAL TRP ILE GLN GLY VAL GLY GLY ALA
SEQRES   7 A  226  TYR ARG ALA THR LEU GLY ASP ASN ALA LEU PRO ARG GLY
SEQRES   8 A  226  THR SER SER ALA ALA ILE ARG GLU MET LEU GLY HIS PHE
SEQRES   9 A  226  SER ASP ALA ASN GLN LYS CYS PRO ASP ALA VAL LEU ILE
SEQRES  10 A  226  ALA GLY GLY TYR SER GLN GLY ALA ALA LEU ALA ALA ALA
SEQRES  11 A  226  SER VAL THR ASP VAL ASP ALA GLY ILE ARG GLU LYS ILE
SEQRES  12 A  226  ALA GLY ALA VAL LEU PHE GLY TYR THR LYS ASN LEU GLN
SEQRES  13 A  226  ASN ARG GLY LYS ILE PRO SER TYR PRO GLU ASP ARG THR
SEQRES  14 A  226  LYS VAL PHE CYS ASN THR GLY ASP LEU VAL CYS THR GLY
SEQRES  15 A  226  SER LEU ILE VAL ALA ALA PRO HIS LEU ALA TYR GLN SER
SEQRES  16 A  226  ALA ALA SER GLY ALA ALA PRO GLU PHE LEU ILE GLN LYS
SEQRES  17 A  226  ALA ASP ALA ALA GLY ALA ALA ALA ALA ALA LEU GLU HIS
SEQRES  18 A  226  HIS HIS HIS HIS HIS
SEQRES   1 B  226  MET LEU PRO ALA GLY GLN ASP ALA ALA ALA LEU GLU ALA
SEQRES   2 B  226  ARG GLN LEU GLY GLY SER ILE THR ARG ASN ASP LEU ALA
SEQRES   3 B  226  ASN GLY ASN SER GLY SER CYS PRO GLY VAL ILE PHE ILE
SEQRES   4 B  226  TYR ALA ARG GLY SER THR GLU SER GLY ASN LEU GLY THR
SEQRES   5 B  226  LEU GLY PRO ARG VAL ALA SER LYS LEU GLU ALA LYS TYR
SEQRES   6 B  226  GLY LYS ASN GLY VAL TRP ILE GLN GLY VAL GLY GLY ALA
SEQRES   7 B  226  TYR ARG ALA THR LEU GLY ASP ASN ALA LEU PRO ARG GLY
SEQRES   8 B  226  THR SER SER ALA ALA ILE ARG GLU MET LEU GLY HIS PHE
SEQRES   9 B  226  SER ASP ALA ASN GLN LYS CYS PRO ASP ALA VAL LEU ILE
SEQRES  10 B  226  ALA GLY GLY TYR SER GLN GLY ALA ALA LEU ALA ALA ALA
SEQRES  11 B  226  SER VAL THR ASP VAL ASP ALA GLY ILE ARG GLU LYS ILE
SEQRES  12 B  226  ALA GLY ALA VAL LEU PHE GLY TYR THR LYS ASN LEU GLN
SEQRES  13 B  226  ASN ARG GLY LYS ILE PRO SER TYR PRO GLU ASP ARG THR
SEQRES  14 B  226  LYS VAL PHE CYS ASN THR GLY ASP LEU VAL CYS THR GLY
SEQRES  15 B  226  SER LEU ILE VAL ALA ALA PRO HIS LEU ALA TYR GLN SER
SEQRES  16 B  226  ALA ALA SER GLY ALA ALA PRO GLU PHE LEU ILE GLN LYS
SEQRES  17 B  226  ALA ASP ALA ALA GLY ALA ALA ALA ALA ALA LEU GLU HIS
SEQRES  18 B  226  HIS HIS HIS HIS HIS
SEQRES   1 C  226  MET LEU PRO ALA GLY GLN ASP ALA ALA ALA LEU GLU ALA
SEQRES   2 C  226  ARG GLN LEU GLY GLY SER ILE THR ARG ASN ASP LEU ALA
SEQRES   3 C  226  ASN GLY ASN SER GLY SER CYS PRO GLY VAL ILE PHE ILE
SEQRES   4 C  226  TYR ALA ARG GLY SER THR GLU SER GLY ASN LEU GLY THR
SEQRES   5 C  226  LEU GLY PRO ARG VAL ALA SER LYS LEU GLU ALA LYS TYR
SEQRES   6 C  226  GLY LYS ASN GLY VAL TRP ILE GLN GLY VAL GLY GLY ALA
SEQRES   7 C  226  TYR ARG ALA THR LEU GLY ASP ASN ALA LEU PRO ARG GLY
SEQRES   8 C  226  THR SER SER ALA ALA ILE ARG GLU MET LEU GLY HIS PHE
SEQRES   9 C  226  SER ASP ALA ASN GLN LYS CYS PRO ASP ALA VAL LEU ILE
SEQRES  10 C  226  ALA GLY GLY TYR SER GLN GLY ALA ALA LEU ALA ALA ALA
SEQRES  11 C  226  SER VAL THR ASP VAL ASP ALA GLY ILE ARG GLU LYS ILE
SEQRES  12 C  226  ALA GLY ALA VAL LEU PHE GLY TYR THR LYS ASN LEU GLN
SEQRES  13 C  226  ASN ARG GLY LYS ILE PRO SER TYR PRO GLU ASP ARG THR
SEQRES  14 C  226  LYS VAL PHE CYS ASN THR GLY ASP LEU VAL CYS THR GLY
SEQRES  15 C  226  SER LEU ILE VAL ALA ALA PRO HIS LEU ALA TYR GLN SER
SEQRES  16 C  226  ALA ALA SER GLY ALA ALA PRO GLU PHE LEU ILE GLN LYS
SEQRES  17 C  226  ALA ASP ALA ALA GLY ALA ALA ALA ALA ALA LEU GLU HIS
SEQRES  18 C  226  HIS HIS HIS HIS HIS
HET    MPD  A1219       8
HET    MPD  A1220       8
HET    MPD  A1221       8
HET    MPD  B1217       8
HET    MPD  B1218       8
HET    MPD  B1219       8
HETNAM     MPD (4S)-2-METHYL-2,4-PENTANEDIOL
FORMUL   4  MPD    6(C6 H14 O2)
FORMUL   5  HOH   *468(H2 O)
HELIX    1   1 ASN A   28  CYS A   32  5                                   5
HELIX    2   2 LEU A   52  GLY A   65  1                                  14
HELIX    3   3 THR A   81  LEU A   87  5                                   7
HELIX    4   4 SER A   92  CYS A  110  1                                  19
HELIX    5   5 SER A  121  VAL A  134  1                                  14
HELIX    6   6 ASP A  135  LYS A  141  1                                   7
HELIX    7   7 PRO A  164  ASP A  166  5                                   3
HELIX    8   8 ASP A  176  GLY A  181  5                                   6
HELIX    9   9 ALA A  186  ALA A  191  5                                   6
HELIX   10  10 TYR A  192  GLY A  198  1                                   7
HELIX   11  11 GLY A  198  LEU A  218  1                                  21
HELIX   12  12 LEU B   52  GLY B   65  1                                  14
HELIX   13  13 THR B   81  LEU B   87  5                                   7
HELIX   14  14 SER B   92  CYS B  110  1                                  19
HELIX   15  15 SER B  121  VAL B  134  1                                  14
HELIX   16  16 ASP B  135  GLU B  140  1                                   6
HELIX   17  17 PRO B  164  ASP B  166  5                                   3
HELIX   18  18 ASP B  176  GLY B  181  5                                   6
HELIX   19  19 PRO B  188  ALA B  191  5                                   4
HELIX   20  20 TYR B  192  GLY B  198  1                                   7
HELIX   21  21 GLY B  198  ALA B  211  1                                  14
HELIX   22  22 ASN C   22  GLY C   27  1                                   6
HELIX   23  23 LEU C   52  GLY C   68  1                                  17
HELIX   24  24 THR C   81  LEU C   87  5                                   7
HELIX   25  25 SER C   92  CYS C  110  1                                  19
HELIX   26  26 SER C  121  VAL C  134  1                                  14
HELIX   27  27 ASP C  135  LYS C  141  1                                   7
HELIX   28  28 PRO C  164  ASP C  166  5                                   3
HELIX   29  29 ASP C  176  GLY C  181  5                                   6
HELIX   30  30 ALA C  186  ALA C  191  5                                   6
HELIX   31  31 TYR C  192  GLY C  198  1                                   7
HELIX   32  32 GLY C  198  ALA C  211  1                                  14
SHEET    1  AA 5 VAL A  69  GLY A  73  0
SHEET    2  AA 5 VAL A  35  ALA A  40  1  O  VAL A  35   N  TRP A  70
SHEET    3  AA 5 VAL A 114  TYR A 120  1  O  VAL A 114   N  ILE A  36
SHEET    4  AA 5 ILE A 142  PHE A 148  1  N  ALA A 143   O  LEU A 115
SHEET    5  AA 5 THR A 168  PHE A 171  1  O  LYS A 169   N  LEU A 147
SHEET    1  AB 2 ILE A 184  VAL A 185  0
SHEET    2  AB 2 VAL B 185  ALA B 186 -1  O  VAL B 185   N  VAL A 185
SHEET    1  BA 5 VAL B  69  GLY B  73  0
SHEET    2  BA 5 VAL B  35  ALA B  40  1  O  VAL B  35   N  TRP B  70
SHEET    3  BA 5 VAL B 114  TYR B 120  1  O  VAL B 114   N  ILE B  36
SHEET    4  BA 5 ILE B 142  PHE B 148  1  N  ALA B 143   O  LEU B 115
SHEET    5  BA 5 THR B 168  PHE B 171  1  O  LYS B 169   N  LEU B 147
SHEET    1  CA 5 VAL C  69  GLY C  73  0
SHEET    2  CA 5 VAL C  35  ALA C  40  1  O  VAL C  35   N  TRP C  70
SHEET    3  CA 5 VAL C 114  TYR C 120  1  O  VAL C 114   N  ILE C  36
SHEET    4  CA 5 ILE C 142  PHE C 148  1  N  ALA C 143   O  LEU C 115
SHEET    5  CA 5 THR C 168  PHE C 171  1  O  LYS C 169   N  LEU C 147
SSBOND   1 CYS A   32    CYS A  110                          1555   1555  2.04
SSBOND   2 CYS A  172    CYS A  179                          1555   1555  2.04
SSBOND   3 CYS B   32    CYS B  110                          1555   1555  2.04
SSBOND   4 CYS B  172    CYS B  179                          1555   1555  2.06
SSBOND   5 CYS C   32    CYS C  110                          1555   1555  2.03
SSBOND   6 CYS C  172    CYS C  179                          1555   1555  2.05
SITE     1 AC1  7 ASN A  22  ASN A  26  ARG A 139  PRO A 164
SITE     2 AC1  7 ARG A 167  HOH A2010  HOH A2212
SITE     1 AC2  6 ASN A  85  SER A 121  LEU A 183  VAL A 185
SITE     2 AC2  6 HOH A2092  LEU B 190
SITE     1 AC3  6 GLY A  42  SER A  43  TYR A 120  SER A 121
SITE     2 AC3  6 HIS A 189  HOH A2048
SITE     1 AC4  6 ASN B  85  SER B 121  VAL B 178  VAL B 185
SITE     2 AC4  6 MPD B1218  HOH B2036
SITE     1 AC5  6 GLY B  42  SER B  43  TYR B 120  HIS B 189
SITE     2 AC5  6 MPD B1217  HOH B2036
SITE     1 AC6  4 LEU B 154  ARG B 157  GLY B 158  HOH B2155
CRYST1   35.906   60.141  241.965  90.00  90.00  90.00 P 21 21 21   12
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.027850  0.000000  0.000000        0.00000
SCALE2      0.000000  0.016628  0.000000        0.00000
SCALE3      0.000000  0.000000  0.004133        0.00000
TER    1421      LEU A 218
TER    2852      ALA B 216
TER    4249      ALA C 213
MASTER      430    0    6   32   17    0   11    6 4762    3   60   54
END