longtext: 5c8x-pdb

content
HEADER    HYDROLASE                               26-JUN-15   5C8X
TITLE     ZHD-INTERMEDIATE COMPLEX AFTER ZHD CRYSTAL SOAKING IN ZEN FOR 20MIN
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: ZEARALENONE HYDROLASE;
COMPND   3 CHAIN: A, B;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: CLONOSTACHYS ROSEA;
SOURCE   3 ORGANISM_TAXID: 29856;
SOURCE   4 GENE: ZHD101;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    LACTONASE, HYDROLASE, ALPHA-BETA FOLD, ZEARALENONE DEGRADE
KEYWDS   2 INTERMEDIATE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    X.-J.HU,Q.QI,W.-J.YANG
REVDAT   1   29-JUN-16 5C8X    0
JRNL        AUTH   D.-M.MING,Q.QI,W.-J.YANG,K.-L.SUN,T.-Y.XU,Q.HUANG,X.-J.HU,
JRNL        AUTH 2 H.LV
JRNL        TITL   A CASE STUDY OF LACTONASE ZHD
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    1.80 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.9_1692
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : ML
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.80
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 47.74
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.340
REMARK   3   COMPLETENESS FOR RANGE        (%) : 100.0
REMARK   3   NUMBER OF REFLECTIONS             : 70440
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.151
REMARK   3   R VALUE            (WORKING SET) : 0.150
REMARK   3   FREE R VALUE                     : 0.168
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.980
REMARK   3   FREE R VALUE TEST SET COUNT      : 3510
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 47.7605 -  5.2610    1.00     2863   167  0.1908 0.1872
REMARK   3     2  5.2610 -  4.1766    1.00     2769   140  0.1701 0.1660
REMARK   3     3  4.1766 -  3.6489    1.00     2724   149  0.1495 0.1607
REMARK   3     4  3.6489 -  3.3153    1.00     2707   137  0.1448 0.1769
REMARK   3     5  3.3153 -  3.0778    1.00     2707   130  0.1446 0.1572
REMARK   3     6  3.0778 -  2.8963    1.00     2667   152  0.1509 0.1659
REMARK   3     7  2.8963 -  2.7513    1.00     2717   124  0.1450 0.1432
REMARK   3     8  2.7513 -  2.6315    1.00     2668   140  0.1466 0.1697
REMARK   3     9  2.6315 -  2.5302    1.00     2681   133  0.1495 0.1713
REMARK   3    10  2.5302 -  2.4429    1.00     2708   125  0.1451 0.1494
REMARK   3    11  2.4429 -  2.3665    1.00     2638   144  0.1439 0.1824
REMARK   3    12  2.3665 -  2.2989    1.00     2693   120  0.1460 0.1652
REMARK   3    13  2.2989 -  2.2384    1.00     2650   144  0.1422 0.1787
REMARK   3    14  2.2384 -  2.1838    1.00     2648   138  0.1379 0.1751
REMARK   3    15  2.1838 -  2.1341    1.00     2645   149  0.1356 0.1451
REMARK   3    16  2.1341 -  2.0887    1.00     2652   147  0.1397 0.1554
REMARK   3    17  2.0887 -  2.0469    1.00     2666   143  0.1370 0.1802
REMARK   3    18  2.0469 -  2.0083    1.00     2629   151  0.1416 0.1773
REMARK   3    19  2.0083 -  1.9724    1.00     2604   132  0.1332 0.1488
REMARK   3    20  1.9724 -  1.9390    1.00     2664   154  0.1320 0.1624
REMARK   3    21  1.9390 -  1.9077    1.00     2638   132  0.1328 0.1664
REMARK   3    22  1.9077 -  1.8784    1.00     2680   132  0.1354 0.1966
REMARK   3    23  1.8784 -  1.8507    1.00     2612   138  0.1432 0.1567
REMARK   3    24  1.8507 -  1.8247    1.00     2639   153  0.1488 0.1924
REMARK   3    25  1.8247 -  1.8000    1.00     2661   136  0.1665 0.2041
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.140
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 14.150
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.007           4458
REMARK   3   ANGLE     :  1.072           6117
REMARK   3   CHIRALITY :  0.046            682
REMARK   3   PLANARITY :  0.006            806
REMARK   3   DIHEDRAL  : 11.445           1613
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 1
REMARK   3   TLS GROUP : 1
REMARK   3    SELECTION: ALL
REMARK   3    ORIGIN FOR THE GROUP (A): -18.2952  15.9064   5.5880
REMARK   3    T TENSOR
REMARK   3      T11:   0.0818 T22:   0.1144
REMARK   3      T33:   0.1161 T12:   0.0004
REMARK   3      T13:  -0.0027 T23:   0.0211
REMARK   3    L TENSOR
REMARK   3      L11:   0.2095 L22:   0.6218
REMARK   3      L33:   0.6862 L12:  -0.0346
REMARK   3      L13:  -0.0649 L23:   0.4384
REMARK   3    S TENSOR
REMARK   3      S11:   0.0139 S12:  -0.0153 S13:  -0.0121
REMARK   3      S21:   0.0025 S22:   0.0054 S23:  -0.0218
REMARK   3      S31:  -0.0067 S32:  -0.0218 S33:  -0.0200
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 5C8X COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 30-JUN-15.
REMARK 100 THE DEPOSITION ID IS D_1000211197.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 04-JAN-15
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 7.4
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SSRF
REMARK 200  BEAMLINE                       : BL17U
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.97923
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 315R
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 70514
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.800
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 100.0
REMARK 200  DATA REDUNDANCY                : 14.10
REMARK 200  R MERGE                    (I) : 0.09400
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 20.3000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.80
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.90
REMARK 200  COMPLETENESS FOR SHELL     (%) : 100.0
REMARK 200  DATA REDUNDANCY IN SHELL       : 14.40
REMARK 200  R MERGE FOR SHELL          (I) : 0.41900
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 7.500
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: NULL
REMARK 200 SOFTWARE USED: MOLREP
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 62.58
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.29
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 1.2 M AMMONIUM DIBASIC PHOSPHATE, 200
REMARK 280  MM KCL, 100 MM IMIDAZOLE, PH 7.4, VAPOR DIFFUSION, HANGING DROP,
REMARK 280  TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X+1/2,-Y,Z+1/2
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       37.29000
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       56.56500
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       44.51500
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       56.56500
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       37.29000
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       44.51500
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 2240 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 20350 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -16.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A     1
REMARK 465     SER A   268
REMARK 465     SER A   269
REMARK 465     VAL A   270
REMARK 465     ASP A   271
REMARK 465     LYS A   272
REMARK 465     LEU A   273
REMARK 465     ALA A   274
REMARK 465     ALA A   275
REMARK 465     ALA A   276
REMARK 465     LEU A   277
REMARK 465     GLU A   278
REMARK 465     HIS A   279
REMARK 465     HIS A   280
REMARK 465     HIS A   281
REMARK 465     HIS A   282
REMARK 465     HIS A   283
REMARK 465     HIS A   284
REMARK 465     MET B     1
REMARK 465     SER B   269
REMARK 465     VAL B   270
REMARK 465     ASP B   271
REMARK 465     LYS B   272
REMARK 465     LEU B   273
REMARK 465     ALA B   274
REMARK 465     ALA B   275
REMARK 465     ALA B   276
REMARK 465     LEU B   277
REMARK 465     GLU B   278
REMARK 465     HIS B   279
REMARK 465     HIS B   280
REMARK 465     HIS B   281
REMARK 465     HIS B   282
REMARK 465     HIS B   283
REMARK 465     HIS B   284
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   OE2  GLU B   171     O    HOH B   401              2.16
REMARK 500   O    HOH B   460     O    HOH B   530              2.18
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ASP A  31     -176.53    -65.76
REMARK 500    SER A  62     -123.41     47.99
REMARK 500    SER A 102     -126.97     65.39
REMARK 500    GLU A 126       74.14     45.76
REMARK 500    PRO A 196       48.45    -80.71
REMARK 500    MET A 241     -110.56   -132.61
REMARK 500    SER B  62     -121.73     46.28
REMARK 500    SER B 102     -128.35     65.20
REMARK 500    GLU B 126       71.53     47.15
REMARK 500    PRO B 196       44.59    -82.27
REMARK 500    MET B 241     -107.98   -130.51
REMARK 500
REMARK 500 REMARK: NULL
REMARK 600
REMARK 600 HETEROGEN
REMARK 600
REMARK 600 ZFR AND FMT ARE USED TO SIMULATE THE INTERMEDIATE IN THE CRYSTAL
REMARK 600 STRUCTURE.
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZFR A 301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue GOL A 302
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue K A 303
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZFR B 301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue GOL B 302
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue K B 303
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 5C7Y   RELATED DB: PDB
REMARK 900 5C7Y CONTAINS THE SAME PROTEIN COMPLEXED WITH SUBSTRATE
REMARK 900 INTERMEDIATE.
REMARK 900 RELATED ID: 5C81   RELATED DB: PDB
REMARK 900 5C81 CONTAINS THE SAME PROTEIN COMPLEXED WITH SUBSTRATE
REMARK 900 INTERMEDIATE.
REMARK 900 RELATED ID: 5C8Z   RELATED DB: PDB
REMARK 900 5C8Z CONTAINS THE SAME PROTEIN COMPLEXED WITH PRODUCT ZGR.
REMARK 999
REMARK 999 SEQUENCE
REMARK 999 THE STRAIN OF CLONOSTACHYS ROSEA IS DIFFERENT FROM UNP Q8NKB0.
DBREF  5C8X A    1   264  UNP    Q8NKB0   Q8NKB0_BIOOC     1    264
DBREF  5C8X B    1   264  UNP    Q8NKB0   Q8NKB0_BIOOC     1    264
SEQADV 5C8X ILE A   26  UNP  Q8NKB0    VAL    26 SEE SEQUENCE DETAILS
SEQADV 5C8X ALA A   69  UNP  Q8NKB0    PRO    69 SEE SEQUENCE DETAILS
SEQADV 5C8X ILE A   87  UNP  Q8NKB0    VAL    87 SEE SEQUENCE DETAILS
SEQADV 5C8X ASN A  148  UNP  Q8NKB0    LYS   148 SEE SEQUENCE DETAILS
SEQADV 5C8X LEU A  168  UNP  Q8NKB0    MET   168 SEE SEQUENCE DETAILS
SEQADV 5C8X VAL A  170  UNP  Q8NKB0    ASP   170 SEE SEQUENCE DETAILS
SEQADV 5C8X GLN A  198  UNP  Q8NKB0    LYS   198 SEE SEQUENCE DETAILS
SEQADV 5C8X VAL A  200  UNP  Q8NKB0    LEU   200 SEE SEQUENCE DETAILS
SEQADV 5C8X TRP A  265  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X ASN A  266  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X SER A  267  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X SER A  268  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X SER A  269  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X VAL A  270  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X ASP A  271  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X LYS A  272  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X LEU A  273  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X ALA A  274  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X ALA A  275  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X ALA A  276  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X LEU A  277  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X GLU A  278  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X HIS A  279  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X HIS A  280  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X HIS A  281  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X HIS A  282  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X HIS A  283  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X HIS A  284  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X ILE B   26  UNP  Q8NKB0    VAL    26 SEE SEQUENCE DETAILS
SEQADV 5C8X ALA B   69  UNP  Q8NKB0    PRO    69 SEE SEQUENCE DETAILS
SEQADV 5C8X ILE B   87  UNP  Q8NKB0    VAL    87 SEE SEQUENCE DETAILS
SEQADV 5C8X ASN B  148  UNP  Q8NKB0    LYS   148 SEE SEQUENCE DETAILS
SEQADV 5C8X LEU B  168  UNP  Q8NKB0    MET   168 SEE SEQUENCE DETAILS
SEQADV 5C8X VAL B  170  UNP  Q8NKB0    ASP   170 SEE SEQUENCE DETAILS
SEQADV 5C8X GLN B  198  UNP  Q8NKB0    LYS   198 SEE SEQUENCE DETAILS
SEQADV 5C8X VAL B  200  UNP  Q8NKB0    LEU   200 SEE SEQUENCE DETAILS
SEQADV 5C8X TRP B  265  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X ASN B  266  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X SER B  267  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X SER B  268  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X SER B  269  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X VAL B  270  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X ASP B  271  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X LYS B  272  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X LEU B  273  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X ALA B  274  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X ALA B  275  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X ALA B  276  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X LEU B  277  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X GLU B  278  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X HIS B  279  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X HIS B  280  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X HIS B  281  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X HIS B  282  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X HIS B  283  UNP  Q8NKB0              EXPRESSION TAG
SEQADV 5C8X HIS B  284  UNP  Q8NKB0              EXPRESSION TAG
SEQRES   1 A  284  MET ARG THR ARG SER THR ILE SER THR PRO ASN GLY ILE
SEQRES   2 A  284  THR TRP TYR TYR GLU GLN GLU GLY THR GLY PRO ASP ILE
SEQRES   3 A  284  VAL LEU VAL PRO ASP GLY LEU GLY GLU CYS GLN MET PHE
SEQRES   4 A  284  ASP SER SER VAL SER GLN ILE ALA ALA GLN GLY PHE ARG
SEQRES   5 A  284  VAL THR THR PHE ASP MET PRO GLY MET SER ARG SER ALA
SEQRES   6 A  284  LYS ALA PRO ALA GLU THR TYR THR GLU VAL THR ALA GLN
SEQRES   7 A  284  LYS LEU ALA SER TYR VAL ILE SER ILE LEU ASP ALA LEU
SEQRES   8 A  284  ASP ILE LYS HIS ALA THR VAL TRP GLY CYS SER SER GLY
SEQRES   9 A  284  ALA SER THR VAL VAL ALA LEU LEU LEU GLY TYR PRO ASP
SEQRES  10 A  284  ARG ILE ARG ASN ALA MET CYS HIS GLU LEU PRO THR LYS
SEQRES  11 A  284  LEU LEU ASP HIS LEU SER ASN THR ALA VAL LEU GLU ASP
SEQRES  12 A  284  GLU GLU ILE SER ASN ILE LEU ALA ASN VAL MET LEU ASN
SEQRES  13 A  284  ASP VAL SER GLY GLY SER GLU ALA TRP GLN ALA LEU GLY
SEQRES  14 A  284  VAL GLU VAL HIS ALA ARG LEU HIS LYS ASN TYR PRO VAL
SEQRES  15 A  284  TRP ALA ARG GLY TYR PRO ARG THR ILE PRO PRO SER ALA
SEQRES  16 A  284  PRO VAL GLN ASP VAL GLU ALA LEU ARG GLY LYS PRO LEU
SEQRES  17 A  284  ASP TRP THR VAL GLY ALA ALA THR PRO THR GLU SER PHE
SEQRES  18 A  284  PHE ASP ASN ILE VAL THR ALA THR LYS ALA GLY VAL ASN
SEQRES  19 A  284  ILE GLY LEU LEU PRO GLY MET HIS PHE PRO TYR VAL SER
SEQRES  20 A  284  HIS PRO ASP VAL PHE ALA LYS TYR VAL VAL GLU THR THR
SEQRES  21 A  284  GLN LYS HIS LEU TRP ASN SER SER SER VAL ASP LYS LEU
SEQRES  22 A  284  ALA ALA ALA LEU GLU HIS HIS HIS HIS HIS HIS
SEQRES   1 B  284  MET ARG THR ARG SER THR ILE SER THR PRO ASN GLY ILE
SEQRES   2 B  284  THR TRP TYR TYR GLU GLN GLU GLY THR GLY PRO ASP ILE
SEQRES   3 B  284  VAL LEU VAL PRO ASP GLY LEU GLY GLU CYS GLN MET PHE
SEQRES   4 B  284  ASP SER SER VAL SER GLN ILE ALA ALA GLN GLY PHE ARG
SEQRES   5 B  284  VAL THR THR PHE ASP MET PRO GLY MET SER ARG SER ALA
SEQRES   6 B  284  LYS ALA PRO ALA GLU THR TYR THR GLU VAL THR ALA GLN
SEQRES   7 B  284  LYS LEU ALA SER TYR VAL ILE SER ILE LEU ASP ALA LEU
SEQRES   8 B  284  ASP ILE LYS HIS ALA THR VAL TRP GLY CYS SER SER GLY
SEQRES   9 B  284  ALA SER THR VAL VAL ALA LEU LEU LEU GLY TYR PRO ASP
SEQRES  10 B  284  ARG ILE ARG ASN ALA MET CYS HIS GLU LEU PRO THR LYS
SEQRES  11 B  284  LEU LEU ASP HIS LEU SER ASN THR ALA VAL LEU GLU ASP
SEQRES  12 B  284  GLU GLU ILE SER ASN ILE LEU ALA ASN VAL MET LEU ASN
SEQRES  13 B  284  ASP VAL SER GLY GLY SER GLU ALA TRP GLN ALA LEU GLY
SEQRES  14 B  284  VAL GLU VAL HIS ALA ARG LEU HIS LYS ASN TYR PRO VAL
SEQRES  15 B  284  TRP ALA ARG GLY TYR PRO ARG THR ILE PRO PRO SER ALA
SEQRES  16 B  284  PRO VAL GLN ASP VAL GLU ALA LEU ARG GLY LYS PRO LEU
SEQRES  17 B  284  ASP TRP THR VAL GLY ALA ALA THR PRO THR GLU SER PHE
SEQRES  18 B  284  PHE ASP ASN ILE VAL THR ALA THR LYS ALA GLY VAL ASN
SEQRES  19 B  284  ILE GLY LEU LEU PRO GLY MET HIS PHE PRO TYR VAL SER
SEQRES  20 B  284  HIS PRO ASP VAL PHE ALA LYS TYR VAL VAL GLU THR THR
SEQRES  21 B  284  GLN LYS HIS LEU TRP ASN SER SER SER VAL ASP LYS LEU
SEQRES  22 B  284  ALA ALA ALA LEU GLU HIS HIS HIS HIS HIS HIS
HET    ZFR  A 301      21
HET    GOL  A 302       6
HET      K  A 303       1
HET    ZFR  B 301      21
HET    GOL  B 302       6
HET      K  B 303       1
HETNAM     ZFR (1E,10S)-1-(3,5-DIHYDROXYPHENYL)-10-HYDROXYUNDEC-1-EN-
HETNAM   2 ZFR  6-ONE
HETNAM     GOL GLYCEROL
HETNAM       K POTASSIUM ION
HETSYN     GOL GLYCERIN; PROPANE-1,2,3-TRIOL
FORMUL   3  ZFR    2(C17 H24 O4)
FORMUL   4  GOL    2(C3 H8 O3)
FORMUL   5    K    2(K 1+)
FORMUL   9  HOH   *336(H2 O)
HELIX    1 AA1 GLU A   35  MET A   38  5                                   4
HELIX    2 AA2 PHE A   39  ALA A   48  1                                  10
HELIX    3 AA3 MET A   61  ALA A   65  5                                   5
HELIX    4 AA4 PRO A   68  THR A   73  5                                   6
HELIX    5 AA5 THR A   76  LEU A   91  1                                  16
HELIX    6 AA6 SER A  102  TYR A  115  1                                  14
HELIX    7 AA7 LEU A  132  ASN A  137  1                                   6
HELIX    8 AA8 THR A  138  LEU A  141  5                                   4
HELIX    9 AA9 GLU A  142  ASP A  157  1                                  16
HELIX   10 AB1 GLY A  161  ALA A  167  1                                   7
HELIX   11 AB2 GLY A  169  TYR A  187  1                                  19
HELIX   12 AB3 ILE A  191  ALA A  195  5                                   5
HELIX   13 AB4 ASP A  199  ARG A  204  1                                   6
HELIX   14 AB5 PRO A  217  ALA A  231  1                                  15
HELIX   15 AB6 PHE A  243  HIS A  248  1                                   6
HELIX   16 AB7 HIS A  248  SER A  267  1                                  20
HELIX   17 AB8 GLU B   35  MET B   38  5                                   4
HELIX   18 AB9 PHE B   39  ALA B   48  1                                  10
HELIX   19 AC1 MET B   61  ALA B   65  5                                   5
HELIX   20 AC2 PRO B   68  THR B   73  5                                   6
HELIX   21 AC3 THR B   76  LEU B   91  1                                  16
HELIX   22 AC4 SER B  102  TYR B  115  1                                  14
HELIX   23 AC5 LEU B  132  ASN B  137  1                                   6
HELIX   24 AC6 THR B  138  LEU B  141  5                                   4
HELIX   25 AC7 GLU B  142  VAL B  158  1                                  17
HELIX   26 AC8 GLY B  161  ALA B  167  1                                   7
HELIX   27 AC9 GLY B  169  TYR B  187  1                                  19
HELIX   28 AD1 ILE B  191  ALA B  195  5                                   5
HELIX   29 AD2 ASP B  199  ARG B  204  1                                   6
HELIX   30 AD3 PRO B  217  GLY B  232  1                                  16
HELIX   31 AD4 PHE B  243  HIS B  248  1                                   6
HELIX   32 AD5 HIS B  248  SER B  268  1                                  21
SHEET    1 AA1 8 THR A   3  SER A   8  0
SHEET    2 AA1 8 THR A  14  GLU A  20 -1  O  GLN A  19   N  THR A   3
SHEET    3 AA1 8 ARG A  52  PHE A  56 -1  O  VAL A  53   N  GLU A  20
SHEET    4 AA1 8 ASP A  25  VAL A  29  1  N  LEU A  28   O  THR A  54
SHEET    5 AA1 8 ALA A  96  CYS A 101  1  O  THR A  97   N  VAL A  27
SHEET    6 AA1 8 ILE A 119  HIS A 125  1  O  MET A 123   N  VAL A  98
SHEET    7 AA1 8 LEU A 208  GLY A 213  1  O  ASP A 209   N  ALA A 122
SHEET    8 AA1 8 ASN A 234  LEU A 238  1  O  ASN A 234   N  TRP A 210
SHEET    1 AA2 8 THR B   3  SER B   8  0
SHEET    2 AA2 8 THR B  14  GLU B  20 -1  O  TRP B  15   N  ILE B   7
SHEET    3 AA2 8 ARG B  52  PHE B  56 -1  O  VAL B  53   N  GLU B  20
SHEET    4 AA2 8 ASP B  25  VAL B  29  1  N  LEU B  28   O  THR B  54
SHEET    5 AA2 8 ALA B  96  CYS B 101  1  O  THR B  97   N  VAL B  27
SHEET    6 AA2 8 ILE B 119  HIS B 125  1  O  MET B 123   N  VAL B  98
SHEET    7 AA2 8 LEU B 208  GLY B 213  1  O  THR B 211   N  CYS B 124
SHEET    8 AA2 8 ASN B 234  LEU B 238  1  O  ASN B 234   N  TRP B 210
SITE     1 AC1 15 ASP A  31  GLY A  32  SER A 102  LYS A 130
SITE     2 AC1 15 LEU A 132  LEU A 135  MET A 154  TRP A 183
SITE     3 AC1 15 TYR A 187  PRO A 188  ILE A 191  PRO A 192
SITE     4 AC1 15 HIS A 242  PHE A 243  HOH A 446
SITE     1 AC2  8 LEU A 127  PRO A 128  THR A 129  LYS A 130
SITE     2 AC2  8 SER A 220  PHE A 221  ASP A 223  HOH A 515
SITE     1 AC3  3 HIS A 248  ASP A 250  VAL A 251
SITE     1 AC4 15 ASP B  31  GLY B  32  SER B 102  LYS B 130
SITE     2 AC4 15 LEU B 132  LEU B 135  MET B 154  TRP B 183
SITE     3 AC4 15 TYR B 187  PRO B 188  ILE B 191  PRO B 192
SITE     4 AC4 15 HIS B 242  PHE B 243  HOH B 420
SITE     1 AC5  7 LEU B 127  PRO B 128  THR B 129  LYS B 130
SITE     2 AC5  7 SER B 220  PHE B 221  ASP B 223
SITE     1 AC6  4 HIS B 248  PRO B 249  ASP B 250  VAL B 251
CRYST1   74.580   89.030  113.130  90.00  90.00  90.00 P 21 21 21    8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.013408  0.000000  0.000000        0.00000
SCALE2      0.000000  0.011232  0.000000        0.00000
SCALE3      0.000000  0.000000  0.008839        0.00000
TER    2162      SER A 267
TER    4281      SER B 268
MASTER      356    0    6   32   16    0   14    6 4474    2   54   44
END