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HEADER    HYDROLASE                               22-APR-16   5JIB
TITLE     CRYSTAL STRUCTURE OF THE THERMOTOGA MARITIMA ACETYL ESTERASE (TM0077)
TITLE    2 COMPLEX WITH A SUBSTRATE ANALOG
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: CEPHALOSPORIN-C DEACETYLASE;
COMPND   3 CHAIN: A, B, C, D, E, F;
COMPND   4 SYNONYM: ACETYLXYLAN ESTERASE;
COMPND   5 EC: 3.1.1.41,3.1.1.72;
COMPND   6 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: THERMOTOGA MARITIMA (STRAIN ATCC 43589 / MSB8 /
SOURCE   3 DSM 3109 / JCM 10099);
SOURCE   4 ORGANISM_TAXID: 243274;
SOURCE   5 STRAIN: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099;
SOURCE   6 GENE: AXEA, TM_0077;
SOURCE   7 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);
SOURCE   8 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE   9 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);
SOURCE  10 EXPRESSION_SYSTEM_VARIANT: RIL;
SOURCE  11 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE  12 EXPRESSION_SYSTEM_PLASMID: PMH1
KEYWDS    HYDROLASE, CARBOHYDRATE METABOLISM, CEPHALOSPORIN DEACETYLASE,
KEYWDS   2 ROSSMANN FOLD
EXPDTA    X-RAY DIFFRACTION
AUTHOR    N.MANOJ
REVDAT   1   01-MAR-17 5JIB    0
JRNL        AUTH   M.K.SINGH,N.MANOJ
JRNL        TITL   CRYSTAL STRUCTURE OF THERMOTOGA MARITIMA ACETYL ESTERASE
JRNL        TITL 2 COMPLEX WITH A SUBSTRATE ANALOG: INSIGHTS INTO THE
JRNL        TITL 3 DISTINCTIVE SUBSTRATE SPECIFICITY IN THE CE7 CARBOHYDRATE
JRNL        TITL 4 ESTERASE FAMILY
JRNL        REF    BIOCHEM. BIOPHYS. RES.        V. 476    63 2016
JRNL        REF  2 COMMUN.
JRNL        REFN                   ESSN 1090-2104
JRNL        PMID   27181355
JRNL        DOI    10.1016/J.BBRC.2016.05.061
REMARK   1
REMARK   1 REFERENCE 1
REMARK   1  AUTH   M.K.SINGH,N.MANOJ
REMARK   1  TITL   AN EXTENDED LOOP IN CE7 CARBOHYDRATE ESTERASE FAMILY IS
REMARK   1  TITL 2 DISPENSABLE FOR OLIGOMERIZATION BUT REQUIRED FOR ACTIVITY
REMARK   1  TITL 3 AND THERMOSTABILITY.
REMARK   1  REF    J. STRUCT. BIOL.                           2016
REMARK   1  REFN                   ESSN 1095-8657
REMARK   1  PMID   27085421
REMARK   1  DOI    10.1016/J.JSB.2016.04.008
REMARK   2
REMARK   2 RESOLUTION.    1.86 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.8.0103
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON
REMARK   3
REMARK   3    REFINEMENT TARGET : NULL
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.86
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 45.97
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000
REMARK   3   COMPLETENESS FOR RANGE        (%) : 94.8
REMARK   3   NUMBER OF REFLECTIONS             : 148760
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.157
REMARK   3   R VALUE            (WORKING SET) : 0.155
REMARK   3   FREE R VALUE                     : 0.192
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000
REMARK   3   FREE R VALUE TEST SET COUNT      : 7863
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 1.86
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 1.91
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 10040
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 86.39
REMARK   3   BIN R VALUE           (WORKING SET) : 0.1840
REMARK   3   BIN FREE R VALUE SET COUNT          : 516
REMARK   3   BIN FREE R VALUE                    : 0.2280
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 15120
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 84
REMARK   3   SOLVENT ATOMS            : 1039
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 19.60
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : 0.21000
REMARK   3    B22 (A**2) : 0.30000
REMARK   3    B33 (A**2) : -0.54000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.23000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.132
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.122
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.076
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 2.508
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.961
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.944
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A): 15686 ; 0.019 ; 0.019
REMARK   3   BOND LENGTHS OTHERS               (A): 14419 ; 0.002 ; 0.020
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 21339 ; 1.845 ; 1.955
REMARK   3   BOND ANGLES OTHERS          (DEGREES): 33108 ; 1.110 ; 3.001
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  1908 ; 6.525 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   738 ;29.654 ;22.846
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  2291 ;11.899 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):   105 ;16.851 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  2208 ; 0.117 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A): 17939 ; 0.011 ; 0.021
REMARK   3   GENERAL PLANES OTHERS             (A):  3898 ; 0.001 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  7656 ; 1.787 ; 1.771
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  7655 ; 1.784 ; 1.770
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  9553 ; 2.557 ; 2.643
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2):  NULL ;  NULL ;  NULL
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : NULL
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING
REMARK   3  POSITIONS U VALUES : REFINED INDIVIDUALLY
REMARK   4
REMARK   4 5JIB COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 24-APR-16.
REMARK 100 THE DEPOSITION ID IS D_1000220649.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 27-SEP-14
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 6.5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : N
REMARK 200  RADIATION SOURCE               : ROTATING ANODE
REMARK 200  BEAMLINE                       : NULL
REMARK 200  X-RAY GENERATOR MODEL          : BRUKER AXS MICROSTAR
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.5418
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : IMAGE PLATE
REMARK 200  DETECTOR MANUFACTURER          : MARRESEARCH
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : IMOSFLM
REMARK 200  DATA SCALING SOFTWARE          : AIMLESS 0.1.30
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 156655
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.860
REMARK 200  RESOLUTION RANGE LOW       (A) : 45.970
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 94.3
REMARK 200  DATA REDUNDANCY                : 7.500
REMARK 200  R MERGE                    (I) : 0.07200
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 19.0000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.86
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.89
REMARK 200  COMPLETENESS FOR SHELL     (%) : 70.7
REMARK 200  DATA REDUNDANCY IN SHELL       : 6.10
REMARK 200  R MERGE FOR SHELL          (I) : 0.36000
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 5.100
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: MOLREP
REMARK 200 STARTING MODEL: 5FDF
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 43.41
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.17
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.05 M AMMONIUM SULFATE, 0.1 M BIS
REMARK 280  -TRIS PH 6.5 AND 30% (V/V) PENTAERYTHRITOLETHOXYLATE (15/4 EO/OH)
REMARK 280  , VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 295K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       57.89000
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: HEXAMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 17740 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 60300 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -119.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A   -11
REMARK 465     GLY A   -10
REMARK 465     SER A    -9
REMARK 465     ASP A    -8
REMARK 465     LYS A    -7
REMARK 465     ILE A    -6
REMARK 465     HIS A    -5
REMARK 465     HIS A    -4
REMARK 465     HIS A    -3
REMARK 465     HIS A    -2
REMARK 465     HIS A    -1
REMARK 465     HIS A     0
REMARK 465     MET A     1
REMARK 465     ALA A     2
REMARK 465     PHE A     3
REMARK 465     GLU A   134
REMARK 465     LYS A   324
REMARK 465     GLY A   325
REMARK 465     MET B   -11
REMARK 465     GLY B   -10
REMARK 465     SER B    -9
REMARK 465     ASP B    -8
REMARK 465     LYS B    -7
REMARK 465     ILE B    -6
REMARK 465     HIS B    -5
REMARK 465     HIS B    -4
REMARK 465     HIS B    -3
REMARK 465     HIS B    -2
REMARK 465     HIS B    -1
REMARK 465     HIS B     0
REMARK 465     MET B     1
REMARK 465     ALA B     2
REMARK 465     PHE B     3
REMARK 465     GLU B   134
REMARK 465     LYS B   324
REMARK 465     GLY B   325
REMARK 465     MET C   -11
REMARK 465     GLY C   -10
REMARK 465     SER C    -9
REMARK 465     ASP C    -8
REMARK 465     LYS C    -7
REMARK 465     ILE C    -6
REMARK 465     HIS C    -5
REMARK 465     HIS C    -4
REMARK 465     HIS C    -3
REMARK 465     HIS C    -2
REMARK 465     HIS C    -1
REMARK 465     HIS C     0
REMARK 465     MET C     1
REMARK 465     ALA C     2
REMARK 465     PHE C     3
REMARK 465     LYS C   324
REMARK 465     GLY C   325
REMARK 465     MET D   -11
REMARK 465     GLY D   -10
REMARK 465     SER D    -9
REMARK 465     ASP D    -8
REMARK 465     LYS D    -7
REMARK 465     ILE D    -6
REMARK 465     HIS D    -5
REMARK 465     HIS D    -4
REMARK 465     HIS D    -3
REMARK 465     HIS D    -2
REMARK 465     HIS D    -1
REMARK 465     HIS D     0
REMARK 465     MET D     1
REMARK 465     ALA D     2
REMARK 465     PHE D     3
REMARK 465     GLU D   134
REMARK 465     LYS D   324
REMARK 465     GLY D   325
REMARK 465     MET E   -11
REMARK 465     GLY E   -10
REMARK 465     SER E    -9
REMARK 465     ASP E    -8
REMARK 465     LYS E    -7
REMARK 465     ILE E    -6
REMARK 465     HIS E    -5
REMARK 465     HIS E    -4
REMARK 465     HIS E    -3
REMARK 465     HIS E    -2
REMARK 465     HIS E    -1
REMARK 465     HIS E     0
REMARK 465     MET E     1
REMARK 465     ALA E     2
REMARK 465     PHE E     3
REMARK 465     GLY E   135
REMARK 465     LYS E   324
REMARK 465     GLY E   325
REMARK 465     MET F   -11
REMARK 465     GLY F   -10
REMARK 465     SER F    -9
REMARK 465     ASP F    -8
REMARK 465     LYS F    -7
REMARK 465     ILE F    -6
REMARK 465     HIS F    -5
REMARK 465     HIS F    -4
REMARK 465     HIS F    -3
REMARK 465     HIS F    -2
REMARK 465     HIS F    -1
REMARK 465     HIS F     0
REMARK 465     MET F     1
REMARK 465     ALA F     2
REMARK 465     PHE F     3
REMARK 465     LYS F   324
REMARK 465     GLY F   325
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     GLU A   9    CG   CD   OE1  OE2
REMARK 470     LYS A  13    CG   CD   CE   NZ
REMARK 470     LYS A  22    CG   CD   CE   NZ
REMARK 470     GLU A  26    CG   CD   OE1  OE2
REMARK 470     GLU A  34    CG   CD   OE1  OE2
REMARK 470     GLU A  36    CG   CD   OE1  OE2
REMARK 470     LYS A  37    CG   CD   CE   NZ
REMARK 470     GLU A  48    CG   CD   OE1  OE2
REMARK 470     GLU A  79    CB   CG   CD   OE1  OE2
REMARK 470     ARG A 153    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU A 169    CG   CD   OE1  OE2
REMARK 470     GLN A 179    CG   CD   OE1  NE2
REMARK 470     LYS A 202    CG   CD   CE   NZ
REMARK 470     LYS A 203    CG   CD   CE   NZ
REMARK 470     LYS A 205    CG   CD   CE   NZ
REMARK 470     ARG A 218    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG A 248    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LYS A 263    CD   CE   NZ
REMARK 470     LYS A 320    CG   CD   CE   NZ
REMARK 470     GLU A 323    CG   CD   OE1  OE2
REMARK 470     GLU B   9    CG   CD   OE1  OE2
REMARK 470     LYS B  13    CG   CD   CE   NZ
REMARK 470     LYS B  22    CG   CD   CE   NZ
REMARK 470     GLU B  29    CG   CD   OE1  OE2
REMARK 470     GLU B  48    CG   CD   OE1  OE2
REMARK 470     GLU B  79    CG   CD   OE1  OE2
REMARK 470     GLU B  80    CG   CD   OE1  OE2
REMARK 470     GLU B  81    CG   CD   OE1  OE2
REMARK 470     LYS B  82    CG   CD   CE   NZ
REMARK 470     GLU B 169    CG   CD   OE1  OE2
REMARK 470     GLU B 244    CG   CD   OE1  OE2
REMARK 470     LYS B 320    CG   CD   CE   NZ
REMARK 470     GLU B 323    CG   CD   OE1  OE2
REMARK 470     GLU C   9    CG   CD   OE1  OE2
REMARK 470     LYS C  13    CG   CD   CE   NZ
REMARK 470     ARG C  15    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU C  17    CG   CD   OE1  OE2
REMARK 470     LYS C  22    CG   CD   CE   NZ
REMARK 470     GLU C  34    CG   CD   OE1  OE2
REMARK 470     GLU C  48    CG   CD   OE1  OE2
REMARK 470     ARG C  65    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LYS C  77    CG   CD   CE   NZ
REMARK 470     GLU C  79    CG   CD   OE1  OE2
REMARK 470     GLU C  81    CG   CD   OE1  OE2
REMARK 470     GLU C 169    CG   CD   OE1  OE2
REMARK 470     GLN C 179    CG   CD   OE1  NE2
REMARK 470     LYS C 202    CG   CD   CE   NZ
REMARK 470     LYS C 203    CG   CD   CE   NZ
REMARK 470     LYS C 205    CG   CD   CE   NZ
REMARK 470     ARG C 218    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LYS C 263    CG   CD   CE   NZ
REMARK 470     LYS C 320    CG   CD   CE   NZ
REMARK 470     GLU D   9    CG   CD   OE1  OE2
REMARK 470     ARG D  15    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU D  17    CG   CD   OE1  OE2
REMARK 470     LYS D  22    CG   CD   CE   NZ
REMARK 470     GLU D  34    CG   CD   OE1  OE2
REMARK 470     GLU D  48    CG   CD   OE1  OE2
REMARK 470     GLU D  79    CG   CD   OE1  OE2
REMARK 470     GLU D  81    CG   CD   OE1  OE2
REMARK 470     LYS D 202    CG   CD   CE   NZ
REMARK 470     LYS D 205    CG   CD   CE   NZ
REMARK 470     ARG D 218    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LYS D 237    CG   CD   CE   NZ
REMARK 470     GLU D 244    CG   CD   OE1  OE2
REMARK 470     LYS D 263    CG   CD   CE   NZ
REMARK 470     LYS D 320    CG   CD   CE   NZ
REMARK 470     GLU D 323    CG   CD   OE1  OE2
REMARK 470     GLU E   9    CG   CD   OE1  OE2
REMARK 470     LYS E  22    CG   CD   CE   NZ
REMARK 470     GLU E  30    CG   CD   OE1  OE2
REMARK 470     GLU E  45    CG   CD   OE1  OE2
REMARK 470     GLU E  48    CG   CD   OE1  OE2
REMARK 470     GLU E  79    CG   CD   OE1  OE2
REMARK 470     GLU E 244    CG   CD   OE1  OE2
REMARK 470     LYS E 263    CG   CD   CE   NZ
REMARK 470     LYS E 320    CG   CD   CE   NZ
REMARK 470     GLU E 323    CG   CD   OE1  OE2
REMARK 470     GLU F   9    CG   CD   OE1  OE2
REMARK 470     LYS F  13    CG   CD   CE   NZ
REMARK 470     LYS F  22    CG   CD   CE   NZ
REMARK 470     GLU F  30    CG   CD   OE1  OE2
REMARK 470     LYS F  37    CG   CD   CE   NZ
REMARK 470     GLU F  48    CG   CD   OE1  OE2
REMARK 470     GLU F  79    CB   CG   CD   OE1  OE2
REMARK 470     GLU F  80    CB   CG   CD   OE1  OE2
REMARK 470     GLU F  81    CB   CG   CD   OE1  OE2
REMARK 470     LYS F  82    CG   CD   CE   NZ
REMARK 470     ARG F 153    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LYS F 202    CG   CD   CE   NZ
REMARK 470     LYS F 203    CG   CD   CE   NZ
REMARK 470     LYS F 205    CG   CD   CE   NZ
REMARK 470     GLU F 244    CG   CD   OE1  OE2
REMARK 470     LYS F 320    CG   CD   CE   NZ
REMARK 470     GLU F 323    CG   CD   OE1  OE2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   OE1  GLU B    55     O    HOH B   501              2.12
REMARK 500   O    HOH C   513     O    HOH C   535              2.19
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION
REMARK 500    GLU E 243   CD    GLU E 243   OE1    -0.067
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    ASP A 163   CB  -  CG  -  OD1 ANGL. DEV. =   5.4 DEGREES
REMARK 500    ARG A 219   NE  -  CZ  -  NH1 ANGL. DEV. =   3.4 DEGREES
REMARK 500    ARG A 219   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.1 DEGREES
REMARK 500    ARG A 240   NE  -  CZ  -  NH1 ANGL. DEV. =   3.3 DEGREES
REMARK 500    ASP A 241   CB  -  CG  -  OD1 ANGL. DEV. =   5.5 DEGREES
REMARK 500    ARG B  18   NE  -  CZ  -  NH1 ANGL. DEV. =   3.2 DEGREES
REMARK 500    ASP B 151   CB  -  CG  -  OD1 ANGL. DEV. =   5.9 DEGREES
REMARK 500    ASP B 151   CB  -  CG  -  OD2 ANGL. DEV. =  -5.8 DEGREES
REMARK 500    PHE B 161   CB  -  CG  -  CD1 ANGL. DEV. =   4.4 DEGREES
REMARK 500    ARG B 240   NE  -  CZ  -  NH1 ANGL. DEV. =   3.5 DEGREES
REMARK 500    ASP B 241   CB  -  CG  -  OD1 ANGL. DEV. =   7.3 DEGREES
REMARK 500    ARG C  18   NE  -  CZ  -  NH1 ANGL. DEV. =   4.0 DEGREES
REMARK 500    ARG C  18   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.8 DEGREES
REMARK 500    ARG C  68   NE  -  CZ  -  NH1 ANGL. DEV. =   3.5 DEGREES
REMARK 500    ARG C 118   NE  -  CZ  -  NH1 ANGL. DEV. =   3.1 DEGREES
REMARK 500    ASP C 151   CB  -  CG  -  OD1 ANGL. DEV. =   7.0 DEGREES
REMARK 500    ASP C 163   CB  -  CG  -  OD1 ANGL. DEV. =   5.8 DEGREES
REMARK 500    ARG C 219   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.5 DEGREES
REMARK 500    ARG C 240   NE  -  CZ  -  NH1 ANGL. DEV. =   3.1 DEGREES
REMARK 500    ASP C 241   CB  -  CG  -  OD1 ANGL. DEV. =   7.4 DEGREES
REMARK 500    ASP D  25   CB  -  CG  -  OD1 ANGL. DEV. =   5.6 DEGREES
REMARK 500    ASP D 163   CB  -  CG  -  OD1 ANGL. DEV. =   5.5 DEGREES
REMARK 500    ASP D 241   CB  -  CG  -  OD1 ANGL. DEV. =   6.5 DEGREES
REMARK 500    ARG D 248   NE  -  CZ  -  NH1 ANGL. DEV. =   4.2 DEGREES
REMARK 500    ARG D 261   NE  -  CZ  -  NH1 ANGL. DEV. =   3.6 DEGREES
REMARK 500    ARG E  15   NE  -  CZ  -  NH1 ANGL. DEV. =   3.2 DEGREES
REMARK 500    ARG E 118   NE  -  CZ  -  NH1 ANGL. DEV. =   4.2 DEGREES
REMARK 500    ARG E 118   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.9 DEGREES
REMARK 500    ASP E 151   CB  -  CG  -  OD1 ANGL. DEV. =   5.5 DEGREES
REMARK 500    ASP E 163   CB  -  CG  -  OD1 ANGL. DEV. =   5.5 DEGREES
REMARK 500    ASP E 241   CB  -  CG  -  OD1 ANGL. DEV. =   8.7 DEGREES
REMARK 500    ARG E 248   NE  -  CZ  -  NH1 ANGL. DEV. =   3.4 DEGREES
REMARK 500    ARG E 261   NE  -  CZ  -  NH1 ANGL. DEV. =   3.7 DEGREES
REMARK 500    ARG F  46   NE  -  CZ  -  NH1 ANGL. DEV. =   3.5 DEGREES
REMARK 500    ARG F  65   NE  -  CZ  -  NH1 ANGL. DEV. =   3.0 DEGREES
REMARK 500    ASP F 151   CB  -  CG  -  OD1 ANGL. DEV. =   6.5 DEGREES
REMARK 500    ASP F 241   CB  -  CG  -  OD1 ANGL. DEV. =   6.3 DEGREES
REMARK 500    ARG F 248   NE  -  CZ  -  NH1 ANGL. DEV. =   3.4 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ASP A   5     -166.56   -102.95
REMARK 500    GLN A 120     -121.92    -96.16
REMARK 500    SER A 122       12.32   -141.84
REMARK 500    PRO A 139      127.48    -38.08
REMARK 500    SER A 188     -115.74     58.90
REMARK 500    VAL A 211       56.82     30.04
REMARK 500    ASN A 302     -144.47    -91.45
REMARK 500    ASP B   5     -168.74   -105.67
REMARK 500    ASP B  41       61.52     38.62
REMARK 500    GLN B 120     -116.98   -101.93
REMARK 500    SER B 188     -120.56     63.63
REMARK 500    VAL B 211       52.55     38.91
REMARK 500    ASN B 302     -142.89    -88.34
REMARK 500    GLN C 120     -121.47    -93.06
REMARK 500    ASP C 138      151.34    -49.62
REMARK 500    PRO C 139      132.52    -38.91
REMARK 500    SER C 188     -119.05     58.91
REMARK 500    VAL C 211       56.21     37.09
REMARK 500    ASN C 302     -147.88    -88.63
REMARK 500    ASN C 302     -147.52    -88.59
REMARK 500    GLN D 120     -117.96    -96.85
REMARK 500    ASP D 138      154.24    -49.36
REMARK 500    PRO D 139      131.37    -39.35
REMARK 500    SER D 188     -120.61     56.35
REMARK 500    VAL D 211       56.60     32.51
REMARK 500    ASN D 302     -144.12    -81.65
REMARK 500    ASP E   5     -165.40   -111.87
REMARK 500    GLN E 120     -117.68    -96.87
REMARK 500    SER E 188     -123.59     63.00
REMARK 500    VAL E 211       54.90     34.67
REMARK 500    ASN E 302     -143.92    -89.90
REMARK 500    ASP F   5     -166.91   -101.09
REMARK 500    GLN F 120     -121.26    -98.26
REMARK 500    TRP F 124      -18.81   -154.74
REMARK 500    SER F 188     -114.11     62.87
REMARK 500    VAL F 211       53.19     39.63
REMARK 500    ASN F 302     -145.09    -91.20
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH B 681        DISTANCE =  6.48 ANGSTROMS
REMARK 525    HOH F 669        DISTANCE =  6.34 ANGSTROMS
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue OIA A 400
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue OIA B 400
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue OIA C 400
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue OIA D 400
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue OIA E 400
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue OIA F 400
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 5FDF   RELATED DB: PDB
REMARK 900 5FDF CONTAINS THE APO-FORM OF THE SAME PROTEIN
REMARK 900 RELATED ID: 5HFN   RELATED DB: PDB
REMARK 900 5HFN CONTAINS A TRUNCATION VARIANT OF THE SAME PROTEIN
REMARK 900 RELATED ID: 3M82   RELATED DB: PDB
REMARK 900 3M82 CONTAINS A COVALENTLY MODIFIED INHIBITOR (PMSF) COMPLEX OF THE
REMARK 900 SAME PROTEIN
REMARK 900 RELATED ID: 3M83   RELATED DB: PDB
REMARK 900 3M83 CONTAINS A COVALENTLY MODIFIED INHIBITOR (PARAOXON)COMPLEX OF
REMARK 900 THE SAME PROTEIN
DBREF  5JIB A    1   325  UNP    Q9WXT2   CAH_THEMA        1    325
DBREF  5JIB B    1   325  UNP    Q9WXT2   CAH_THEMA        1    325
DBREF  5JIB C    1   325  UNP    Q9WXT2   CAH_THEMA        1    325
DBREF  5JIB D    1   325  UNP    Q9WXT2   CAH_THEMA        1    325
DBREF  5JIB E    1   325  UNP    Q9WXT2   CAH_THEMA        1    325
DBREF  5JIB F    1   325  UNP    Q9WXT2   CAH_THEMA        1    325
SEQADV 5JIB MET A  -11  UNP  Q9WXT2              INITIATING METHIONINE
SEQADV 5JIB GLY A  -10  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB SER A   -9  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB ASP A   -8  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB LYS A   -7  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB ILE A   -6  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS A   -5  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS A   -4  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS A   -3  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS A   -2  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS A   -1  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS A    0  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB MET B  -11  UNP  Q9WXT2              INITIATING METHIONINE
SEQADV 5JIB GLY B  -10  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB SER B   -9  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB ASP B   -8  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB LYS B   -7  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB ILE B   -6  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS B   -5  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS B   -4  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS B   -3  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS B   -2  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS B   -1  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS B    0  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB MET C  -11  UNP  Q9WXT2              INITIATING METHIONINE
SEQADV 5JIB GLY C  -10  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB SER C   -9  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB ASP C   -8  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB LYS C   -7  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB ILE C   -6  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS C   -5  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS C   -4  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS C   -3  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS C   -2  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS C   -1  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS C    0  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB MET D  -11  UNP  Q9WXT2              INITIATING METHIONINE
SEQADV 5JIB GLY D  -10  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB SER D   -9  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB ASP D   -8  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB LYS D   -7  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB ILE D   -6  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS D   -5  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS D   -4  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS D   -3  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS D   -2  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS D   -1  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS D    0  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB MET E  -11  UNP  Q9WXT2              INITIATING METHIONINE
SEQADV 5JIB GLY E  -10  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB SER E   -9  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB ASP E   -8  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB LYS E   -7  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB ILE E   -6  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS E   -5  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS E   -4  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS E   -3  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS E   -2  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS E   -1  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS E    0  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB MET F  -11  UNP  Q9WXT2              INITIATING METHIONINE
SEQADV 5JIB GLY F  -10  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB SER F   -9  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB ASP F   -8  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB LYS F   -7  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB ILE F   -6  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS F   -5  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS F   -4  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS F   -3  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS F   -2  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS F   -1  UNP  Q9WXT2              EXPRESSION TAG
SEQADV 5JIB HIS F    0  UNP  Q9WXT2              EXPRESSION TAG
SEQRES   1 A  337  MET GLY SER ASP LYS ILE HIS HIS HIS HIS HIS HIS MET
SEQRES   2 A  337  ALA PHE PHE ASP LEU PRO LEU GLU GLU LEU LYS LYS TYR
SEQRES   3 A  337  ARG PRO GLU ARG TYR GLU GLU LYS ASP PHE ASP GLU PHE
SEQRES   4 A  337  TRP GLU GLU THR LEU ALA GLU SER GLU LYS PHE PRO LEU
SEQRES   5 A  337  ASP PRO VAL PHE GLU ARG MET GLU SER HIS LEU LYS THR
SEQRES   6 A  337  VAL GLU ALA TYR ASP VAL THR PHE SER GLY TYR ARG GLY
SEQRES   7 A  337  GLN ARG ILE LYS GLY TRP LEU LEU VAL PRO LYS LEU GLU
SEQRES   8 A  337  GLU GLU LYS LEU PRO CYS VAL VAL GLN TYR ILE GLY TYR
SEQRES   9 A  337  ASN GLY GLY ARG GLY PHE PRO HIS ASP TRP LEU PHE TRP
SEQRES  10 A  337  PRO SER MET GLY TYR ILE CYS PHE VAL MET ASP THR ARG
SEQRES  11 A  337  GLY GLN GLY SER GLY TRP LEU LYS GLY ASP THR PRO ASP
SEQRES  12 A  337  TYR PRO GLU GLY PRO VAL ASP PRO GLN TYR PRO GLY PHE
SEQRES  13 A  337  MET THR ARG GLY ILE LEU ASP PRO ARG THR TYR TYR TYR
SEQRES  14 A  337  ARG ARG VAL PHE THR ASP ALA VAL ARG ALA VAL GLU ALA
SEQRES  15 A  337  ALA ALA SER PHE PRO GLN VAL ASP GLN GLU ARG ILE VAL
SEQRES  16 A  337  ILE ALA GLY GLY SER GLN GLY GLY GLY ILE ALA LEU ALA
SEQRES  17 A  337  VAL SER ALA LEU SER LYS LYS ALA LYS ALA LEU LEU CYS
SEQRES  18 A  337  ASP VAL PRO PHE LEU CYS HIS PHE ARG ARG ALA VAL GLN
SEQRES  19 A  337  LEU VAL ASP THR HIS PRO TYR ALA GLU ILE THR ASN PHE
SEQRES  20 A  337  LEU LYS THR HIS ARG ASP LYS GLU GLU ILE VAL PHE ARG
SEQRES  21 A  337  THR LEU SER TYR PHE ASP GLY VAL ASN PHE ALA ALA ARG
SEQRES  22 A  337  ALA LYS ILE PRO ALA LEU PHE SER VAL GLY LEU MET ASP
SEQRES  23 A  337  ASN ILE CYS PRO PRO SER THR VAL PHE ALA ALA TYR ASN
SEQRES  24 A  337  TYR TYR ALA GLY PRO LYS GLU ILE ARG ILE TYR PRO TYR
SEQRES  25 A  337  ASN ASN HIS GLU GLY GLY GLY SER PHE GLN ALA VAL GLU
SEQRES  26 A  337  GLN VAL LYS PHE LEU LYS LYS LEU PHE GLU LYS GLY
SEQRES   1 B  337  MET GLY SER ASP LYS ILE HIS HIS HIS HIS HIS HIS MET
SEQRES   2 B  337  ALA PHE PHE ASP LEU PRO LEU GLU GLU LEU LYS LYS TYR
SEQRES   3 B  337  ARG PRO GLU ARG TYR GLU GLU LYS ASP PHE ASP GLU PHE
SEQRES   4 B  337  TRP GLU GLU THR LEU ALA GLU SER GLU LYS PHE PRO LEU
SEQRES   5 B  337  ASP PRO VAL PHE GLU ARG MET GLU SER HIS LEU LYS THR
SEQRES   6 B  337  VAL GLU ALA TYR ASP VAL THR PHE SER GLY TYR ARG GLY
SEQRES   7 B  337  GLN ARG ILE LYS GLY TRP LEU LEU VAL PRO LYS LEU GLU
SEQRES   8 B  337  GLU GLU LYS LEU PRO CYS VAL VAL GLN TYR ILE GLY TYR
SEQRES   9 B  337  ASN GLY GLY ARG GLY PHE PRO HIS ASP TRP LEU PHE TRP
SEQRES  10 B  337  PRO SER MET GLY TYR ILE CYS PHE VAL MET ASP THR ARG
SEQRES  11 B  337  GLY GLN GLY SER GLY TRP LEU LYS GLY ASP THR PRO ASP
SEQRES  12 B  337  TYR PRO GLU GLY PRO VAL ASP PRO GLN TYR PRO GLY PHE
SEQRES  13 B  337  MET THR ARG GLY ILE LEU ASP PRO ARG THR TYR TYR TYR
SEQRES  14 B  337  ARG ARG VAL PHE THR ASP ALA VAL ARG ALA VAL GLU ALA
SEQRES  15 B  337  ALA ALA SER PHE PRO GLN VAL ASP GLN GLU ARG ILE VAL
SEQRES  16 B  337  ILE ALA GLY GLY SER GLN GLY GLY GLY ILE ALA LEU ALA
SEQRES  17 B  337  VAL SER ALA LEU SER LYS LYS ALA LYS ALA LEU LEU CYS
SEQRES  18 B  337  ASP VAL PRO PHE LEU CYS HIS PHE ARG ARG ALA VAL GLN
SEQRES  19 B  337  LEU VAL ASP THR HIS PRO TYR ALA GLU ILE THR ASN PHE
SEQRES  20 B  337  LEU LYS THR HIS ARG ASP LYS GLU GLU ILE VAL PHE ARG
SEQRES  21 B  337  THR LEU SER TYR PHE ASP GLY VAL ASN PHE ALA ALA ARG
SEQRES  22 B  337  ALA LYS ILE PRO ALA LEU PHE SER VAL GLY LEU MET ASP
SEQRES  23 B  337  ASN ILE CYS PRO PRO SER THR VAL PHE ALA ALA TYR ASN
SEQRES  24 B  337  TYR TYR ALA GLY PRO LYS GLU ILE ARG ILE TYR PRO TYR
SEQRES  25 B  337  ASN ASN HIS GLU GLY GLY GLY SER PHE GLN ALA VAL GLU
SEQRES  26 B  337  GLN VAL LYS PHE LEU LYS LYS LEU PHE GLU LYS GLY
SEQRES   1 C  337  MET GLY SER ASP LYS ILE HIS HIS HIS HIS HIS HIS MET
SEQRES   2 C  337  ALA PHE PHE ASP LEU PRO LEU GLU GLU LEU LYS LYS TYR
SEQRES   3 C  337  ARG PRO GLU ARG TYR GLU GLU LYS ASP PHE ASP GLU PHE
SEQRES   4 C  337  TRP GLU GLU THR LEU ALA GLU SER GLU LYS PHE PRO LEU
SEQRES   5 C  337  ASP PRO VAL PHE GLU ARG MET GLU SER HIS LEU LYS THR
SEQRES   6 C  337  VAL GLU ALA TYR ASP VAL THR PHE SER GLY TYR ARG GLY
SEQRES   7 C  337  GLN ARG ILE LYS GLY TRP LEU LEU VAL PRO LYS LEU GLU
SEQRES   8 C  337  GLU GLU LYS LEU PRO CYS VAL VAL GLN TYR ILE GLY TYR
SEQRES   9 C  337  ASN GLY GLY ARG GLY PHE PRO HIS ASP TRP LEU PHE TRP
SEQRES  10 C  337  PRO SER MET GLY TYR ILE CYS PHE VAL MET ASP THR ARG
SEQRES  11 C  337  GLY GLN GLY SER GLY TRP LEU LYS GLY ASP THR PRO ASP
SEQRES  12 C  337  TYR PRO GLU GLY PRO VAL ASP PRO GLN TYR PRO GLY PHE
SEQRES  13 C  337  MET THR ARG GLY ILE LEU ASP PRO ARG THR TYR TYR TYR
SEQRES  14 C  337  ARG ARG VAL PHE THR ASP ALA VAL ARG ALA VAL GLU ALA
SEQRES  15 C  337  ALA ALA SER PHE PRO GLN VAL ASP GLN GLU ARG ILE VAL
SEQRES  16 C  337  ILE ALA GLY GLY SER GLN GLY GLY GLY ILE ALA LEU ALA
SEQRES  17 C  337  VAL SER ALA LEU SER LYS LYS ALA LYS ALA LEU LEU CYS
SEQRES  18 C  337  ASP VAL PRO PHE LEU CYS HIS PHE ARG ARG ALA VAL GLN
SEQRES  19 C  337  LEU VAL ASP THR HIS PRO TYR ALA GLU ILE THR ASN PHE
SEQRES  20 C  337  LEU LYS THR HIS ARG ASP LYS GLU GLU ILE VAL PHE ARG
SEQRES  21 C  337  THR LEU SER TYR PHE ASP GLY VAL ASN PHE ALA ALA ARG
SEQRES  22 C  337  ALA LYS ILE PRO ALA LEU PHE SER VAL GLY LEU MET ASP
SEQRES  23 C  337  ASN ILE CYS PRO PRO SER THR VAL PHE ALA ALA TYR ASN
SEQRES  24 C  337  TYR TYR ALA GLY PRO LYS GLU ILE ARG ILE TYR PRO TYR
SEQRES  25 C  337  ASN ASN HIS GLU GLY GLY GLY SER PHE GLN ALA VAL GLU
SEQRES  26 C  337  GLN VAL LYS PHE LEU LYS LYS LEU PHE GLU LYS GLY
SEQRES   1 D  337  MET GLY SER ASP LYS ILE HIS HIS HIS HIS HIS HIS MET
SEQRES   2 D  337  ALA PHE PHE ASP LEU PRO LEU GLU GLU LEU LYS LYS TYR
SEQRES   3 D  337  ARG PRO GLU ARG TYR GLU GLU LYS ASP PHE ASP GLU PHE
SEQRES   4 D  337  TRP GLU GLU THR LEU ALA GLU SER GLU LYS PHE PRO LEU
SEQRES   5 D  337  ASP PRO VAL PHE GLU ARG MET GLU SER HIS LEU LYS THR
SEQRES   6 D  337  VAL GLU ALA TYR ASP VAL THR PHE SER GLY TYR ARG GLY
SEQRES   7 D  337  GLN ARG ILE LYS GLY TRP LEU LEU VAL PRO LYS LEU GLU
SEQRES   8 D  337  GLU GLU LYS LEU PRO CYS VAL VAL GLN TYR ILE GLY TYR
SEQRES   9 D  337  ASN GLY GLY ARG GLY PHE PRO HIS ASP TRP LEU PHE TRP
SEQRES  10 D  337  PRO SER MET GLY TYR ILE CYS PHE VAL MET ASP THR ARG
SEQRES  11 D  337  GLY GLN GLY SER GLY TRP LEU LYS GLY ASP THR PRO ASP
SEQRES  12 D  337  TYR PRO GLU GLY PRO VAL ASP PRO GLN TYR PRO GLY PHE
SEQRES  13 D  337  MET THR ARG GLY ILE LEU ASP PRO ARG THR TYR TYR TYR
SEQRES  14 D  337  ARG ARG VAL PHE THR ASP ALA VAL ARG ALA VAL GLU ALA
SEQRES  15 D  337  ALA ALA SER PHE PRO GLN VAL ASP GLN GLU ARG ILE VAL
SEQRES  16 D  337  ILE ALA GLY GLY SER GLN GLY GLY GLY ILE ALA LEU ALA
SEQRES  17 D  337  VAL SER ALA LEU SER LYS LYS ALA LYS ALA LEU LEU CYS
SEQRES  18 D  337  ASP VAL PRO PHE LEU CYS HIS PHE ARG ARG ALA VAL GLN
SEQRES  19 D  337  LEU VAL ASP THR HIS PRO TYR ALA GLU ILE THR ASN PHE
SEQRES  20 D  337  LEU LYS THR HIS ARG ASP LYS GLU GLU ILE VAL PHE ARG
SEQRES  21 D  337  THR LEU SER TYR PHE ASP GLY VAL ASN PHE ALA ALA ARG
SEQRES  22 D  337  ALA LYS ILE PRO ALA LEU PHE SER VAL GLY LEU MET ASP
SEQRES  23 D  337  ASN ILE CYS PRO PRO SER THR VAL PHE ALA ALA TYR ASN
SEQRES  24 D  337  TYR TYR ALA GLY PRO LYS GLU ILE ARG ILE TYR PRO TYR
SEQRES  25 D  337  ASN ASN HIS GLU GLY GLY GLY SER PHE GLN ALA VAL GLU
SEQRES  26 D  337  GLN VAL LYS PHE LEU LYS LYS LEU PHE GLU LYS GLY
SEQRES   1 E  337  MET GLY SER ASP LYS ILE HIS HIS HIS HIS HIS HIS MET
SEQRES   2 E  337  ALA PHE PHE ASP LEU PRO LEU GLU GLU LEU LYS LYS TYR
SEQRES   3 E  337  ARG PRO GLU ARG TYR GLU GLU LYS ASP PHE ASP GLU PHE
SEQRES   4 E  337  TRP GLU GLU THR LEU ALA GLU SER GLU LYS PHE PRO LEU
SEQRES   5 E  337  ASP PRO VAL PHE GLU ARG MET GLU SER HIS LEU LYS THR
SEQRES   6 E  337  VAL GLU ALA TYR ASP VAL THR PHE SER GLY TYR ARG GLY
SEQRES   7 E  337  GLN ARG ILE LYS GLY TRP LEU LEU VAL PRO LYS LEU GLU
SEQRES   8 E  337  GLU GLU LYS LEU PRO CYS VAL VAL GLN TYR ILE GLY TYR
SEQRES   9 E  337  ASN GLY GLY ARG GLY PHE PRO HIS ASP TRP LEU PHE TRP
SEQRES  10 E  337  PRO SER MET GLY TYR ILE CYS PHE VAL MET ASP THR ARG
SEQRES  11 E  337  GLY GLN GLY SER GLY TRP LEU LYS GLY ASP THR PRO ASP
SEQRES  12 E  337  TYR PRO GLU GLY PRO VAL ASP PRO GLN TYR PRO GLY PHE
SEQRES  13 E  337  MET THR ARG GLY ILE LEU ASP PRO ARG THR TYR TYR TYR
SEQRES  14 E  337  ARG ARG VAL PHE THR ASP ALA VAL ARG ALA VAL GLU ALA
SEQRES  15 E  337  ALA ALA SER PHE PRO GLN VAL ASP GLN GLU ARG ILE VAL
SEQRES  16 E  337  ILE ALA GLY GLY SER GLN GLY GLY GLY ILE ALA LEU ALA
SEQRES  17 E  337  VAL SER ALA LEU SER LYS LYS ALA LYS ALA LEU LEU CYS
SEQRES  18 E  337  ASP VAL PRO PHE LEU CYS HIS PHE ARG ARG ALA VAL GLN
SEQRES  19 E  337  LEU VAL ASP THR HIS PRO TYR ALA GLU ILE THR ASN PHE
SEQRES  20 E  337  LEU LYS THR HIS ARG ASP LYS GLU GLU ILE VAL PHE ARG
SEQRES  21 E  337  THR LEU SER TYR PHE ASP GLY VAL ASN PHE ALA ALA ARG
SEQRES  22 E  337  ALA LYS ILE PRO ALA LEU PHE SER VAL GLY LEU MET ASP
SEQRES  23 E  337  ASN ILE CYS PRO PRO SER THR VAL PHE ALA ALA TYR ASN
SEQRES  24 E  337  TYR TYR ALA GLY PRO LYS GLU ILE ARG ILE TYR PRO TYR
SEQRES  25 E  337  ASN ASN HIS GLU GLY GLY GLY SER PHE GLN ALA VAL GLU
SEQRES  26 E  337  GLN VAL LYS PHE LEU LYS LYS LEU PHE GLU LYS GLY
SEQRES   1 F  337  MET GLY SER ASP LYS ILE HIS HIS HIS HIS HIS HIS MET
SEQRES   2 F  337  ALA PHE PHE ASP LEU PRO LEU GLU GLU LEU LYS LYS TYR
SEQRES   3 F  337  ARG PRO GLU ARG TYR GLU GLU LYS ASP PHE ASP GLU PHE
SEQRES   4 F  337  TRP GLU GLU THR LEU ALA GLU SER GLU LYS PHE PRO LEU
SEQRES   5 F  337  ASP PRO VAL PHE GLU ARG MET GLU SER HIS LEU LYS THR
SEQRES   6 F  337  VAL GLU ALA TYR ASP VAL THR PHE SER GLY TYR ARG GLY
SEQRES   7 F  337  GLN ARG ILE LYS GLY TRP LEU LEU VAL PRO LYS LEU GLU
SEQRES   8 F  337  GLU GLU LYS LEU PRO CYS VAL VAL GLN TYR ILE GLY TYR
SEQRES   9 F  337  ASN GLY GLY ARG GLY PHE PRO HIS ASP TRP LEU PHE TRP
SEQRES  10 F  337  PRO SER MET GLY TYR ILE CYS PHE VAL MET ASP THR ARG
SEQRES  11 F  337  GLY GLN GLY SER GLY TRP LEU LYS GLY ASP THR PRO ASP
SEQRES  12 F  337  TYR PRO GLU GLY PRO VAL ASP PRO GLN TYR PRO GLY PHE
SEQRES  13 F  337  MET THR ARG GLY ILE LEU ASP PRO ARG THR TYR TYR TYR
SEQRES  14 F  337  ARG ARG VAL PHE THR ASP ALA VAL ARG ALA VAL GLU ALA
SEQRES  15 F  337  ALA ALA SER PHE PRO GLN VAL ASP GLN GLU ARG ILE VAL
SEQRES  16 F  337  ILE ALA GLY GLY SER GLN GLY GLY GLY ILE ALA LEU ALA
SEQRES  17 F  337  VAL SER ALA LEU SER LYS LYS ALA LYS ALA LEU LEU CYS
SEQRES  18 F  337  ASP VAL PRO PHE LEU CYS HIS PHE ARG ARG ALA VAL GLN
SEQRES  19 F  337  LEU VAL ASP THR HIS PRO TYR ALA GLU ILE THR ASN PHE
SEQRES  20 F  337  LEU LYS THR HIS ARG ASP LYS GLU GLU ILE VAL PHE ARG
SEQRES  21 F  337  THR LEU SER TYR PHE ASP GLY VAL ASN PHE ALA ALA ARG
SEQRES  22 F  337  ALA LYS ILE PRO ALA LEU PHE SER VAL GLY LEU MET ASP
SEQRES  23 F  337  ASN ILE CYS PRO PRO SER THR VAL PHE ALA ALA TYR ASN
SEQRES  24 F  337  TYR TYR ALA GLY PRO LYS GLU ILE ARG ILE TYR PRO TYR
SEQRES  25 F  337  ASN ASN HIS GLU GLY GLY GLY SER PHE GLN ALA VAL GLU
SEQRES  26 F  337  GLN VAL LYS PHE LEU LYS LYS LEU PHE GLU LYS GLY
HET    OIA  A 400      14
HET    OIA  B 400      14
HET    OIA  C 400      14
HET    OIA  D 400      14
HET    OIA  E 400      14
HET    OIA  F 400      14
HETNAM     OIA [(3S)-2-OXO-2,3-DIHYDRO-1H-INDOL-3-YL]ACETIC ACID
FORMUL   7  OIA    6(C10 H9 N O3)
FORMUL  13  HOH   *1039(H2 O)
HELIX    1 AA1 PRO A    7  LYS A   12  1                                   6
HELIX    2 AA2 ASP A   23  LYS A   37  1                                  15
HELIX    3 AA3 TYR A   64  GLY A   66  5                                   3
HELIX    4 AA4 PHE A   98  TRP A  102  5                                   5
HELIX    5 AA5 LEU A  103  MET A  108  1                                   6
HELIX    6 AA6 ASP A  151  THR A  154  5                                   4
HELIX    7 AA7 TYR A  155  PHE A  174  1                                  20
HELIX    8 AA8 SER A  188  SER A  201  1                                  14
HELIX    9 AA9 HIS A  216  VAL A  224  1                                   9
HELIX   10 AB1 PRO A  228  HIS A  239  1                                  12
HELIX   11 AB2 LYS A  242  TYR A  252  1                                  11
HELIX   12 AB3 ASP A  254  ALA A  260  1                                   7
HELIX   13 AB4 PRO A  278  TYR A  289  1                                  12
HELIX   14 AB5 GLY A  306  GLU A  323  1                                  18
HELIX   15 AB6 PRO B    7  LYS B   12  1                                   6
HELIX   16 AB7 ASP B   23  LYS B   37  1                                  15
HELIX   17 AB8 TYR B   64  GLY B   66  5                                   3
HELIX   18 AB9 PHE B   98  TRP B  102  5                                   5
HELIX   19 AC1 LEU B  103  MET B  108  1                                   6
HELIX   20 AC2 ASP B  151  THR B  154  5                                   4
HELIX   21 AC3 TYR B  155  PHE B  174  1                                  20
HELIX   22 AC4 SER B  188  SER B  201  1                                  14
HELIX   23 AC5 HIS B  216  VAL B  224  1                                   9
HELIX   24 AC6 PRO B  228  HIS B  239  1                                  12
HELIX   25 AC7 LYS B  242  TYR B  252  1                                  11
HELIX   26 AC8 ASP B  254  ALA B  260  1                                   7
HELIX   27 AC9 PRO B  278  TYR B  289  1                                  12
HELIX   28 AD1 GLY B  306  PHE B  322  1                                  17
HELIX   29 AD2 PRO C    7  LYS C   12  1                                   6
HELIX   30 AD3 ASP C   23  LYS C   37  1                                  15
HELIX   31 AD4 TYR C   64  GLY C   66  5                                   3
HELIX   32 AD5 PHE C   98  TRP C  102  5                                   5
HELIX   33 AD6 LEU C  103  MET C  108  1                                   6
HELIX   34 AD7 ASP C  151  THR C  154  5                                   4
HELIX   35 AD8 TYR C  155  PHE C  174  1                                  20
HELIX   36 AD9 SER C  188  SER C  201  1                                  14
HELIX   37 AE1 HIS C  216  VAL C  224  1                                   9
HELIX   38 AE2 PRO C  228  HIS C  239  1                                  12
HELIX   39 AE3 LYS C  242  TYR C  252  1                                  11
HELIX   40 AE4 ASP C  254  ALA C  260  1                                   7
HELIX   41 AE5 PRO C  278  TYR C  289  1                                  12
HELIX   42 AE6 GLY C  306  GLU C  323  1                                  18
HELIX   43 AE7 PRO D    7  LYS D   12  1                                   6
HELIX   44 AE8 ASP D   23  LYS D   37  1                                  15
HELIX   45 AE9 TYR D   64  GLY D   66  5                                   3
HELIX   46 AF1 PHE D   98  TRP D  102  5                                   5
HELIX   47 AF2 LEU D  103  MET D  108  1                                   6
HELIX   48 AF3 ASP D  151  THR D  154  5                                   4
HELIX   49 AF4 TYR D  155  SER D  173  1                                  19
HELIX   50 AF5 SER D  188  SER D  201  1                                  14
HELIX   51 AF6 HIS D  216  VAL D  224  1                                   9
HELIX   52 AF7 TYR D  229  HIS D  239  1                                  11
HELIX   53 AF8 LYS D  242  TYR D  252  1                                  11
HELIX   54 AF9 ASP D  254  ALA D  260  1                                   7
HELIX   55 AG1 PRO D  278  TYR D  289  1                                  12
HELIX   56 AG2 GLY D  306  GLU D  323  1                                  18
HELIX   57 AG3 PRO E    7  LYS E   12  1                                   6
HELIX   58 AG4 ASP E   23  LYS E   37  1                                  15
HELIX   59 AG5 TYR E   64  GLY E   66  5                                   3
HELIX   60 AG6 PHE E   98  TRP E  102  5                                   5
HELIX   61 AG7 LEU E  103  MET E  108  1                                   6
HELIX   62 AG8 TYR E  155  SER E  173  1                                  19
HELIX   63 AG9 SER E  188  SER E  201  1                                  14
HELIX   64 AH1 HIS E  216  VAL E  224  1                                   9
HELIX   65 AH2 TYR E  229  HIS E  239  1                                  11
HELIX   66 AH3 LYS E  242  TYR E  252  1                                  11
HELIX   67 AH4 ASP E  254  ALA E  260  1                                   7
HELIX   68 AH5 PRO E  278  TYR E  289  1                                  12
HELIX   69 AH6 GLY E  306  GLU E  323  1                                  18
HELIX   70 AH7 PRO F    7  LYS F   13  1                                   7
HELIX   71 AH8 ASP F   23  LYS F   37  1                                  15
HELIX   72 AH9 TYR F   64  GLY F   66  5                                   3
HELIX   73 AI1 PHE F   98  TRP F  102  5                                   5
HELIX   74 AI2 LEU F  103  MET F  108  1                                   6
HELIX   75 AI3 TYR F  155  SER F  173  1                                  19
HELIX   76 AI4 SER F  188  SER F  201  1                                  14
HELIX   77 AI5 HIS F  216  VAL F  224  1                                   9
HELIX   78 AI6 TYR F  229  HIS F  239  1                                  11
HELIX   79 AI7 LYS F  242  TYR F  252  1                                  11
HELIX   80 AI8 ASP F  254  ALA F  260  1                                   7
HELIX   81 AI9 PRO F  278  TYR F  289  1                                  12
HELIX   82 AJ1 GLY F  306  GLU F  323  1                                  18
SHEET    1 AA1 9 VAL A  43  ARG A  46  0
SHEET    2 AA1 9 VAL A  54  SER A  62 -1  O  THR A  60   N  VAL A  43
SHEET    3 AA1 9 ARG A  68  PRO A  76 -1  O  ILE A  69   N  PHE A  61
SHEET    4 AA1 9 ILE A 111  MET A 115 -1  O  VAL A 114   N  TRP A  72
SHEET    5 AA1 9 LEU A  83  TYR A  89  1  N  GLN A  88   O  PHE A 113
SHEET    6 AA1 9 VAL A 177  GLY A 187  1  O  VAL A 183   N  VAL A  87
SHEET    7 AA1 9 ALA A 206  ASP A 210  1  O  LEU A 208   N  ILE A 184
SHEET    8 AA1 9 ALA A 266  GLY A 271  1  O  LEU A 267   N  CYS A 209
SHEET    9 AA1 9 LYS A 293  TYR A 298  1  O  GLU A 294   N  PHE A 268
SHEET    1 AA2 9 VAL B  43  ARG B  46  0
SHEET    2 AA2 9 VAL B  54  SER B  62 -1  O  THR B  60   N  VAL B  43
SHEET    3 AA2 9 ARG B  68  PRO B  76 -1  O  VAL B  75   N  GLU B  55
SHEET    4 AA2 9 ILE B 111  MET B 115 -1  O  VAL B 114   N  TRP B  72
SHEET    5 AA2 9 LEU B  83  GLN B  88  1  N  GLN B  88   O  PHE B 113
SHEET    6 AA2 9 VAL B 177  GLY B 187  1  O  VAL B 183   N  CYS B  85
SHEET    7 AA2 9 ALA B 206  ASP B 210  1  O  ASP B 210   N  GLY B 186
SHEET    8 AA2 9 ALA B 266  GLY B 271  1  O  LEU B 267   N  CYS B 209
SHEET    9 AA2 9 LYS B 293  TYR B 298  1  O  GLU B 294   N  PHE B 268
SHEET    1 AA3 9 VAL C  43  ARG C  46  0
SHEET    2 AA3 9 VAL C  54  SER C  62 -1  O  ASP C  58   N  GLU C  45
SHEET    3 AA3 9 ARG C  68  PRO C  76 -1  O  ILE C  69   N  PHE C  61
SHEET    4 AA3 9 ILE C 111  MET C 115 -1  O  CYS C 112   N  LEU C  74
SHEET    5 AA3 9 LEU C  83  GLN C  88  1  N  GLN C  88   O  PHE C 113
SHEET    6 AA3 9 VAL C 177  GLY C 187  1  O  VAL C 183   N  CYS C  85
SHEET    7 AA3 9 ALA C 206  ASP C 210  1  O  LEU C 208   N  ILE C 184
SHEET    8 AA3 9 ALA C 266  GLY C 271  1  O  LEU C 267   N  CYS C 209
SHEET    9 AA3 9 LYS C 293  TYR C 298  1  O  GLU C 294   N  PHE C 268
SHEET    1 AA4 9 VAL D  43  ARG D  46  0
SHEET    2 AA4 9 VAL D  54  SER D  62 -1  O  ASP D  58   N  GLU D  45
SHEET    3 AA4 9 ARG D  68  PRO D  76 -1  O  VAL D  75   N  GLU D  55
SHEET    4 AA4 9 ILE D 111  MET D 115 -1  O  VAL D 114   N  TRP D  72
SHEET    5 AA4 9 LEU D  83  GLN D  88  1  N  PRO D  84   O  ILE D 111
SHEET    6 AA4 9 VAL D 177  GLY D 187  1  O  VAL D 183   N  CYS D  85
SHEET    7 AA4 9 ALA D 206  ASP D 210  1  O  ALA D 206   N  ILE D 184
SHEET    8 AA4 9 ALA D 266  GLY D 271  1  O  LEU D 267   N  CYS D 209
SHEET    9 AA4 9 LYS D 293  TYR D 298  1  O  GLU D 294   N  PHE D 268
SHEET    1 AA5 9 VAL E  43  ARG E  46  0
SHEET    2 AA5 9 VAL E  54  SER E  62 -1  O  THR E  60   N  VAL E  43
SHEET    3 AA5 9 ARG E  68  PRO E  76 -1  O  ILE E  69   N  PHE E  61
SHEET    4 AA5 9 ILE E 111  MET E 115 -1  O  VAL E 114   N  TRP E  72
SHEET    5 AA5 9 LEU E  83  GLN E  88  1  N  GLN E  88   O  PHE E 113
SHEET    6 AA5 9 VAL E 177  GLY E 187  1  O  VAL E 183   N  CYS E  85
SHEET    7 AA5 9 ALA E 206  ASP E 210  1  O  ALA E 206   N  ILE E 184
SHEET    8 AA5 9 ALA E 266  GLY E 271  1  O  LEU E 267   N  LEU E 207
SHEET    9 AA5 9 LYS E 293  TYR E 298  1  O  TYR E 298   N  VAL E 270
SHEET    1 AA6 9 VAL F  43  ARG F  46  0
SHEET    2 AA6 9 VAL F  54  SER F  62 -1  O  ASP F  58   N  GLU F  45
SHEET    3 AA6 9 ARG F  68  PRO F  76 -1  O  ILE F  69   N  PHE F  61
SHEET    4 AA6 9 ILE F 111  MET F 115 -1  O  VAL F 114   N  TRP F  72
SHEET    5 AA6 9 LEU F  83  GLN F  88  1  N  GLN F  88   O  PHE F 113
SHEET    6 AA6 9 VAL F 177  GLY F 187  1  O  VAL F 183   N  CYS F  85
SHEET    7 AA6 9 ALA F 206  ASP F 210  1  O  LEU F 208   N  ILE F 184
SHEET    8 AA6 9 ALA F 266  GLY F 271  1  O  LEU F 267   N  LEU F 207
SHEET    9 AA6 9 LYS F 293  TYR F 298  1  O  GLU F 294   N  PHE F 268
CISPEP   1 HIS A  227    PRO A  228          0         7.58
CISPEP   2 HIS B  227    PRO B  228          0        10.74
CISPEP   3 HIS C  227    PRO C  228          0        11.56
CISPEP   4 HIS D  227    PRO D  228          0        11.81
CISPEP   5 HIS E  227    PRO E  228          0        10.09
CISPEP   6 HIS F  227    PRO F  228          0        10.91
SITE     1 AC1  7 GLY A  91  TYR A  92  SER A 188  GLN A 189
SITE     2 AC1  7 HIS A 227  HIS A 303  HOH A 603
SITE     1 AC2  7 GLY B  91  TYR B  92  SER B 188  GLN B 189
SITE     2 AC2  7 HIS B 227  HIS B 303  HOH B 517
SITE     1 AC3  7 GLY C  91  TYR C  92  SER C 188  GLN C 189
SITE     2 AC3  7 HIS C 227  HIS C 303  HOH C 501
SITE     1 AC4  7 GLY D  91  TYR D  92  SER D 188  GLN D 189
SITE     2 AC4  7 HIS D 227  HIS D 303  HOH D 519
SITE     1 AC5  7 GLY E  91  TYR E  92  SER E 188  GLN E 189
SITE     2 AC5  7 HIS E 227  HIS E 303  HOH E 548
SITE     1 AC6  7 GLY F  91  TYR F  92  SER F 188  GLN F 189
SITE     2 AC6  7 HIS F 227  HIS F 303  HOH F 556
CRYST1   89.810  115.780  103.200  90.00 109.98  90.00 P 1 21 1     12
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.011135  0.000000  0.004048        0.00000
SCALE2      0.000000  0.008637  0.000000        0.00000
SCALE3      0.000000  0.000000  0.010310        0.00000
TER    2498      GLU A 323
TER    5030      GLU B 323
TER    7546      GLU C 323
TER   10062      GLU D 323
TER   12611      GLU E 323
TER   15131      GLU F 323
MASTER      646    0    6   82   54    0   12    616243    6   84  156
END