longtext: 5oj6-pdb

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HEADER    CELL ADHESION                           20-JUL-17   5OJ6
TITLE     CRYSTAL STRUCTURE OF THE CHICKEN MDGA1 ECTODOMAIN IN COMPLEX WITH THE
TITLE    2 HUMAN NEUROLIGIN 1 (NL1(-A-B)) CHOLINESTERASE DOMAIN.
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: NEUROLIGIN-1;
COMPND   3 CHAIN: A;
COMPND   4 ENGINEERED: YES;
COMPND   5 MOL_ID: 2;
COMPND   6 MOLECULE: MAM DOMAIN-CONTAINING GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR
COMPND   7 PROTEIN 1;
COMPND   8 CHAIN: B;
COMPND   9 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE   3 ORGANISM_COMMON: HUMAN;
SOURCE   4 ORGANISM_TAXID: 9606;
SOURCE   5 GENE: NLGN1, KIAA1070;
SOURCE   6 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 9606;
SOURCE   8 EXPRESSION_SYSTEM_CELL_LINE: HEK293S GNTI-/-;
SOURCE   9 EXPRESSION_SYSTEM_PLASMID: PHLSEC;
SOURCE  10 MOL_ID: 2;
SOURCE  11 ORGANISM_SCIENTIFIC: GALLUS GALLUS;
SOURCE  12 ORGANISM_COMMON: CHICKEN;
SOURCE  13 ORGANISM_TAXID: 9031;
SOURCE  14 GENE: MDGA1;
SOURCE  15 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE  16 EXPRESSION_SYSTEM_TAXID: 9606;
SOURCE  17 EXPRESSION_SYSTEM_CELL_LINE: HEK293S GNTI-/-;
SOURCE  18 EXPRESSION_SYSTEM_PLASMID: PHLSEC
KEYWDS    NEUROLIGIN-NEUREXIN, SYNAPSE FORMATION, AUSTISM SPECTRUM DISORDERS
KEYWDS   2 (ASDS), SYNAPTIC TRANSMISSION, CELL ADHESION
EXPDTA    X-RAY DIFFRACTION
AUTHOR    J.ELEGHEERT,A.J.CLAYTON,A.R.ARICESCU
REVDAT   1   23-AUG-17 5OJ6    0
JRNL        AUTH   J.ELEGHEERT,V.CVETKOVSKA,A.J.CLAYTON,C.HEROVEN,
JRNL        AUTH 2 K.M.VENNEKENS,S.N.SMUKOWSKI,M.C.REGAN,W.JIA,A.C.SMITH,
JRNL        AUTH 3 H.FURUKAWA,J.N.SAVAS,J.DE WIT,J.BEGBIE,A.M.CRAIG,
JRNL        AUTH 4 A.R.ARICESCU
JRNL        TITL   STRUCTURAL MECHANISM FOR MODULATION OF SYNAPTIC
JRNL        TITL 2 NEUROLIGIN-NEUREXIN SIGNALING BY MDGA PROTEINS
JRNL        REF    NEURON                        V.  95   896 2017
JRNL        REFN                   ISSN 0896-6273
JRNL        DOI    10.1016/J.NEURON.2017.07.040
REMARK   2
REMARK   2 RESOLUTION.    3.30 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX (DEV_2044:)
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : NULL
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 3.30
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 72.36
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.340
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.4
REMARK   3   NUMBER OF REFLECTIONS             : 29572
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.229
REMARK   3   R VALUE            (WORKING SET) : 0.227
REMARK   3   FREE R VALUE                     : 0.277
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.980
REMARK   3   FREE R VALUE TEST SET COUNT      : 1474
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 72.3795 -  7.3371    0.97     2678   131  0.2352 0.2621
REMARK   3     2  7.3371 -  5.8244    0.99     2620   142  0.2448 0.2579
REMARK   3     3  5.8244 -  5.0884    1.00     2595   142  0.2035 0.2972
REMARK   3     4  5.0884 -  4.6233    0.98     2557   130  0.1837 0.2546
REMARK   3     5  4.6233 -  4.2919    0.97     2515   119  0.1890 0.2084
REMARK   3     6  4.2919 -  4.0389    0.99     2545   121  0.1994 0.2616
REMARK   3     7  4.0389 -  3.8366    0.99     2534   151  0.2241 0.3015
REMARK   3     8  3.8366 -  3.6696    0.99     2519   147  0.2546 0.2906
REMARK   3     9  3.6696 -  3.5284    0.99     2535   135  0.2663 0.3426
REMARK   3    10  3.5284 -  3.4066    1.00     2527   138  0.2906 0.3657
REMARK   3    11  3.4066 -  3.3001    0.96     2473   118  0.3181 0.3838
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : NULL
REMARK   3   SOLVENT RADIUS     : 1.00
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.470
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 28.590
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.003          10061
REMARK   3   ANGLE     :  0.939          13737
REMARK   3   CHIRALITY :  0.041           1569
REMARK   3   PLANARITY :  0.004           1774
REMARK   3   DIHEDRAL  : 11.487           6051
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 5OJ6 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 20-JUL-17.
REMARK 100 THE DEPOSITION ID IS D_1200005895.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 15-MAY-14
REMARK 200  TEMPERATURE           (KELVIN) : 80
REMARK 200  PH                             : NULL
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : DIAMOND
REMARK 200  BEAMLINE                       : I04-1
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.92000
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 6M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XIA2
REMARK 200  DATA SCALING SOFTWARE          : AIMLESS
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 29576
REMARK 200  RESOLUTION RANGE HIGH      (A) : 3.300
REMARK 200  RESOLUTION RANGE LOW       (A) : 92.070
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.7
REMARK 200  DATA REDUNDANCY                : 4.500
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 15.6000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.30
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 3.39
REMARK 200  COMPLETENESS FOR SHELL     (%) : 95.4
REMARK 200  DATA REDUNDANCY IN SHELL       : 4.60
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 1.600
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: 5OJ2
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 57.84
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.92
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1M NA.HEPES PH 7.0, 7.5% W/V
REMARK 280  PEG8000, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 2
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,-Y,Z
REMARK 290       3555   -X+1/2,Y+1/2,-Z
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000       54.71000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       92.07000
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       54.71000
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       92.07000
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 14960 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 111120 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: 37.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350   BIOMT1   2 -1.000000  0.000000  0.000000      109.42000
REMARK 350   BIOMT2   2  0.000000 -1.000000  0.000000      368.28000
REMARK 350   BIOMT3   2  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     THR A    44
REMARK 465     GLY A    45
REMARK 465     GLN A    46
REMARK 465     LYS A    47
REMARK 465     LEU A    48
REMARK 465     ASP A    49
REMARK 465     ASP A    50
REMARK 465     ASP A   181
REMARK 465     ASP A   182
REMARK 465     ILE A   183
REMARK 465     THR A   577
REMARK 465     LYS A   578
REMARK 465     PHE A   579
REMARK 465     ILE A   580
REMARK 465     HIS A   581
REMARK 465     THR A   582
REMARK 465     LYS A   583
REMARK 465     ASN A   634
REMARK 465     ASP A   635
REMARK 465     ARG A   636
REMARK 465     THR A   637
REMARK 465     LYS A   638
REMARK 465     HIS A   639
REMARK 465     HIS A   640
REMARK 465     HIS A   641
REMARK 465     HIS A   642
REMARK 465     HIS A   643
REMARK 465     HIS A   644
REMARK 465     VAL B    38
REMARK 465     LYS B    39
REMARK 465     GLU B    40
REMARK 465     ASP B    41
REMARK 465     ASN B    42
REMARK 465     ILE B    43
REMARK 465     SER B    44
REMARK 465     ILE B   140
REMARK 465     SER B   141
REMARK 465     ASP B   142
REMARK 465     VAL B   143
REMARK 465     ARG B   144
REMARK 465     GLY B   145
REMARK 465     SER B   146
REMARK 465     SER B   179
REMARK 465     GLN B   180
REMARK 465     ASP B   181
REMARK 465     ASN B   182
REMARK 465     GLY B   183
REMARK 465     ALA B   378
REMARK 465     ARG B   379
REMARK 465     PHE B   380
REMARK 465     PRO B   584
REMARK 465     PRO B   585
REMARK 465     ALA B   586
REMARK 465     GLU B   587
REMARK 465     GLN B   588
REMARK 465     GLU B   735
REMARK 465     PRO B   736
REMARK 465     ILE B   737
REMARK 465     ASN B   738
REMARK 465     TYR B   739
REMARK 465     PRO B   740
REMARK 465     SER B   741
REMARK 465     PRO B   742
REMARK 465     THR B   743
REMARK 465     ASP B   744
REMARK 465     ASN B   745
REMARK 465     THR B   746
REMARK 465     CYS B   747
REMARK 465     ARG B   748
REMARK 465     PHE B   749
REMARK 465     GLU B   750
REMARK 465     ASP B   751
REMARK 465     GLU B   752
REMARK 465     LYS B   753
REMARK 465     ILE B   754
REMARK 465     CYS B   755
REMARK 465     GLY B   756
REMARK 465     PHE B   757
REMARK 465     VAL B   758
REMARK 465     GLN B   759
REMARK 465     ASP B   760
REMARK 465     LYS B   761
REMARK 465     MET B   762
REMARK 465     ASP B   763
REMARK 465     ASN B   764
REMARK 465     PHE B   765
REMARK 465     ASP B   766
REMARK 465     TRP B   767
REMARK 465     THR B   768
REMARK 465     ARG B   769
REMARK 465     GLN B   770
REMARK 465     ASN B   771
REMARK 465     ALA B   772
REMARK 465     LEU B   773
REMARK 465     THR B   774
REMARK 465     GLN B   775
REMARK 465     ASN B   776
REMARK 465     PRO B   777
REMARK 465     LYS B   778
REMARK 465     ARG B   779
REMARK 465     THR B   780
REMARK 465     VAL B   781
REMARK 465     ASN B   782
REMARK 465     THR B   783
REMARK 465     GLY B   784
REMARK 465     PRO B   785
REMARK 465     PRO B   786
REMARK 465     THR B   787
REMARK 465     ASP B   788
REMARK 465     ILE B   789
REMARK 465     SER B   790
REMARK 465     GLY B   791
REMARK 465     THR B   792
REMARK 465     PRO B   793
REMARK 465     GLU B   794
REMARK 465     GLY B   795
REMARK 465     TYR B   796
REMARK 465     TYR B   797
REMARK 465     MET B   798
REMARK 465     PHE B   799
REMARK 465     ILE B   800
REMARK 465     GLU B   801
REMARK 465     ALA B   802
REMARK 465     SER B   803
REMARK 465     ARG B   804
REMARK 465     PRO B   805
REMARK 465     ARG B   806
REMARK 465     VAL B   807
REMARK 465     THR B   808
REMARK 465     GLY B   809
REMARK 465     ASP B   810
REMARK 465     LYS B   811
REMARK 465     ALA B   812
REMARK 465     ARG B   813
REMARK 465     LEU B   814
REMARK 465     ILE B   815
REMARK 465     SER B   816
REMARK 465     PRO B   817
REMARK 465     LEU B   818
REMARK 465     TYR B   819
REMARK 465     ASN B   820
REMARK 465     ILE B   821
REMARK 465     THR B   822
REMARK 465     ALA B   823
REMARK 465     LYS B   824
REMARK 465     TYR B   825
REMARK 465     TYR B   826
REMARK 465     CYS B   827
REMARK 465     VAL B   828
REMARK 465     SER B   829
REMARK 465     PHE B   830
REMARK 465     TYR B   831
REMARK 465     TYR B   832
REMARK 465     HIS B   833
REMARK 465     MET B   834
REMARK 465     TYR B   835
REMARK 465     GLY B   836
REMARK 465     LYS B   837
REMARK 465     HIS B   838
REMARK 465     ILE B   839
REMARK 465     GLY B   840
REMARK 465     SER B   841
REMARK 465     LEU B   842
REMARK 465     ASN B   843
REMARK 465     LEU B   844
REMARK 465     LEU B   845
REMARK 465     VAL B   846
REMARK 465     ARG B   847
REMARK 465     VAL B   848
REMARK 465     ARG B   849
REMARK 465     ASN B   850
REMARK 465     LYS B   851
REMARK 465     ARG B   852
REMARK 465     ALA B   853
REMARK 465     ILE B   854
REMARK 465     ASP B   855
REMARK 465     THR B   856
REMARK 465     GLN B   857
REMARK 465     VAL B   858
REMARK 465     TRP B   859
REMARK 465     SER B   860
REMARK 465     LEU B   861
REMARK 465     SER B   862
REMARK 465     GLY B   863
REMARK 465     ASN B   864
REMARK 465     ARG B   865
REMARK 465     GLY B   866
REMARK 465     ASN B   867
REMARK 465     MET B   868
REMARK 465     TRP B   869
REMARK 465     GLN B   870
REMARK 465     GLN B   871
REMARK 465     ALA B   872
REMARK 465     HIS B   873
REMARK 465     VAL B   874
REMARK 465     PRO B   875
REMARK 465     ILE B   876
REMARK 465     ASN B   877
REMARK 465     PRO B   878
REMARK 465     PRO B   879
REMARK 465     GLY B   880
REMARK 465     PRO B   881
REMARK 465     PHE B   882
REMARK 465     GLN B   883
REMARK 465     ILE B   884
REMARK 465     ILE B   885
REMARK 465     PHE B   886
REMARK 465     GLU B   887
REMARK 465     GLY B   888
REMARK 465     VAL B   889
REMARK 465     ARG B   890
REMARK 465     GLY B   891
REMARK 465     THR B   892
REMARK 465     SER B   893
REMARK 465     TYR B   894
REMARK 465     GLU B   895
REMARK 465     GLY B   896
REMARK 465     ASP B   897
REMARK 465     ILE B   898
REMARK 465     ALA B   899
REMARK 465     ILE B   900
REMARK 465     ASP B   901
REMARK 465     ASP B   902
REMARK 465     VAL B   903
REMARK 465     THR B   904
REMARK 465     LEU B   905
REMARK 465     LYS B   906
REMARK 465     LYS B   907
REMARK 465     GLY B   908
REMARK 465     ASP B   909
REMARK 465     CYS B   910
REMARK 465     PRO B   911
REMARK 465     ARG B   912
REMARK 465     LYS B   913
REMARK 465     PRO B   914
REMARK 465     ILE B   915
REMARK 465     GLY B   916
REMARK 465     PRO B   917
REMARK 465     ASN B   918
REMARK 465     LYS B   919
REMARK 465     GLY B   920
REMARK 465     THR B   921
REMARK 465     LYS B   922
REMARK 465     HIS B   923
REMARK 465     HIS B   924
REMARK 465     HIS B   925
REMARK 465     HIS B   926
REMARK 465     HIS B   927
REMARK 465     HIS B   928
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     GLU A 163    CG   CD   OE1  OE2
REMARK 470     ARG A 184    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ASP A 185    CG   OD1  OD2
REMARK 470     GLN A 510    CG   CD   OE1  NE2
REMARK 470     HIS A 629    CG   ND1  CD2  CE1  NE2
REMARK 470     HIS A 631    CG   ND1  CD2  CE1  NE2
REMARK 470     PHE B 147    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     ASN B 203    CG   OD1  ND2
REMARK 470     GLN B 289    CG   CD   OE1  NE2
REMARK 470     LYS B 376    CG   CD   CE   NZ
REMARK 470     ARG B 388    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ASN B 639    CG   OD1  ND2
REMARK 470     LYS B 648    CG   CD   CE   NZ
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS
REMARK 500
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.
REMARK 500
REMARK 500 DISTANCE CUTOFF:
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE
REMARK 500   OG   SER B   643     O4   NAG B  1001     4477     2.07
REMARK 500   O    VAL B   273     NE2  GLN B   690     4577     2.09
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    PRO A  53       98.92    -67.80
REMARK 500    ASP A 106     -158.84    -99.81
REMARK 500    ASN A 138       44.84   -142.47
REMARK 500    THR A 162       55.10   -101.90
REMARK 500    ASP A 185     -110.99     59.03
REMARK 500    TYR A 201       -7.10     80.43
REMARK 500    ASP A 239     -158.43   -140.11
REMARK 500    ALA A 372      -63.22    -93.75
REMARK 500    ASP A 380      -75.00   -121.56
REMARK 500    TYR A 440       65.18   -112.22
REMARK 500    ASP A 462       40.95     79.70
REMARK 500    TRP A 482      -53.45   -124.87
REMARK 500    ARG A 610      158.63    178.85
REMARK 500    ARG A 616       43.60     39.61
REMARK 500    ASN A 632        9.63     81.14
REMARK 500    ASP B  81     -136.91     55.27
REMARK 500    LYS B  82       84.31    -66.40
REMARK 500    ARG B 171       55.97   -115.85
REMARK 500    GLN B 193       50.89   -101.78
REMARK 500    ASN B 285       19.93     51.24
REMARK 500    ASN B 312       18.73   -145.30
REMARK 500    PRO B 338      173.10    -57.14
REMARK 500    ASP B 382     -119.26     65.87
REMARK 500    LEU B 384      -56.42     72.43
REMARK 500    ASP B 404       70.70     56.12
REMARK 500    TYR B 410      107.81    -59.17
REMARK 500    GLN B 420      105.77    -58.77
REMARK 500    LYS B 446     -130.96     56.40
REMARK 500    SER B 457     -179.11    -62.05
REMARK 500    LEU B 562      -64.47    -98.46
REMARK 500    LEU B 581     -160.49   -110.72
REMARK 500    ASP B 590      -13.61     76.16
REMARK 500    VAL B 599       84.86    -65.40
REMARK 500    ASP B 636       64.97   -102.20
REMARK 500    GLN B 644       23.36     44.50
REMARK 500    LYS B 645       16.11     54.01
REMARK 500    VAL B 664     -159.27   -136.96
REMARK 500    LEU B 677      -53.37     68.46
REMARK 500    LYS B 691      162.70    175.09
REMARK 500
REMARK 500 REMARK: NULL
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG B 1009
REMARK 800  bound to ASN B 90
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG B 1007
REMARK 800  bound to ASN B 235
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG B 1001
REMARK 800  bound to ASN B 257
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG B 1011
REMARK 800  bound to ASN B 292
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG B 1002
REMARK 800  bound to ASN B 307
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG B
REMARK 800  1003 through BMA B 1005 bound to ASN B 331
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG B 1008
REMARK 800  bound to ASN B 432
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG B 1010
REMARK 800  bound to ASN B 577
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG B 1006
REMARK 800  bound to ASN B 649
DBREF  5OJ6 A   46   635  UNP    Q8N2Q7   NLGN1_HUMAN     46    618
DBREF  5OJ6 B   19   919  UNP    Q0WYX8   MDGA1_CHICK     19    919
SEQADV 5OJ6 THR A   44  UNP  Q8N2Q7              EXPRESSION TAG
SEQADV 5OJ6 GLY A   45  UNP  Q8N2Q7              EXPRESSION TAG
SEQADV 5OJ6     A       UNP  Q8N2Q7    GLY   278 DELETION
SEQADV 5OJ6     A       UNP  Q8N2Q7    ASN   279 DELETION
SEQADV 5OJ6     A       UNP  Q8N2Q7    ARG   280 DELETION
SEQADV 5OJ6     A       UNP  Q8N2Q7    TRP   281 DELETION
SEQADV 5OJ6     A       UNP  Q8N2Q7    SER   282 DELETION
SEQADV 5OJ6     A       UNP  Q8N2Q7    ASN   283 DELETION
SEQADV 5OJ6     A       UNP  Q8N2Q7    SER   284 DELETION
SEQADV 5OJ6     A       UNP  Q8N2Q7    THR   285 DELETION
SEQADV 5OJ6     A       UNP  Q8N2Q7    LYS   286 DELETION
SEQADV 5OJ6 ARG A  636  UNP  Q8N2Q7              EXPRESSION TAG
SEQADV 5OJ6 THR A  637  UNP  Q8N2Q7              EXPRESSION TAG
SEQADV 5OJ6 LYS A  638  UNP  Q8N2Q7              EXPRESSION TAG
SEQADV 5OJ6 HIS A  639  UNP  Q8N2Q7              EXPRESSION TAG
SEQADV 5OJ6 HIS A  640  UNP  Q8N2Q7              EXPRESSION TAG
SEQADV 5OJ6 HIS A  641  UNP  Q8N2Q7              EXPRESSION TAG
SEQADV 5OJ6 HIS A  642  UNP  Q8N2Q7              EXPRESSION TAG
SEQADV 5OJ6 HIS A  643  UNP  Q8N2Q7              EXPRESSION TAG
SEQADV 5OJ6 HIS A  644  UNP  Q8N2Q7              EXPRESSION TAG
SEQADV 5OJ6 LYS B  120  UNP  Q0WYX8    ARG   120 ENGINEERED MUTATION
SEQADV 5OJ6 GLY B  920  UNP  Q0WYX8              EXPRESSION TAG
SEQADV 5OJ6 THR B  921  UNP  Q0WYX8              EXPRESSION TAG
SEQADV 5OJ6 LYS B  922  UNP  Q0WYX8              EXPRESSION TAG
SEQADV 5OJ6 HIS B  923  UNP  Q0WYX8              EXPRESSION TAG
SEQADV 5OJ6 HIS B  924  UNP  Q0WYX8              EXPRESSION TAG
SEQADV 5OJ6 HIS B  925  UNP  Q0WYX8              EXPRESSION TAG
SEQADV 5OJ6 HIS B  926  UNP  Q0WYX8              EXPRESSION TAG
SEQADV 5OJ6 HIS B  927  UNP  Q0WYX8              EXPRESSION TAG
SEQADV 5OJ6 HIS B  928  UNP  Q0WYX8              EXPRESSION TAG
SEQRES   1 A  575  THR GLY GLN LYS LEU ASP ASP VAL ASP PRO LEU VAL ALA
SEQRES   2 A  575  THR ASN PHE GLY LYS ILE ARG GLY ILE LYS LYS GLU LEU
SEQRES   3 A  575  ASN ASN GLU ILE LEU GLY PRO VAL ILE GLN PHE LEU GLY
SEQRES   4 A  575  VAL PRO TYR ALA ALA PRO PRO THR GLY GLU ARG ARG PHE
SEQRES   5 A  575  GLN PRO PRO GLU PRO PRO SER PRO TRP SER ASP ILE ARG
SEQRES   6 A  575  ASN ALA THR GLN PHE ALA PRO VAL CYS PRO GLN ASN ILE
SEQRES   7 A  575  ILE ASP GLY ARG LEU PRO GLU VAL MET LEU PRO VAL TRP
SEQRES   8 A  575  PHE THR ASN ASN LEU ASP VAL VAL SER SER TYR VAL GLN
SEQRES   9 A  575  ASP GLN SER GLU ASP CYS LEU TYR LEU ASN ILE TYR VAL
SEQRES  10 A  575  PRO THR GLU ASP ASP ILE ARG ASP SER GLY GLY PRO LYS
SEQRES  11 A  575  PRO VAL MET VAL TYR ILE HIS GLY GLY SER TYR MET GLU
SEQRES  12 A  575  GLY THR GLY ASN LEU TYR ASP GLY SER VAL LEU ALA SER
SEQRES  13 A  575  TYR GLY ASN VAL ILE VAL ILE THR VAL ASN TYR ARG LEU
SEQRES  14 A  575  GLY VAL LEU GLY PHE LEU SER THR GLY ASP GLN ALA ALA
SEQRES  15 A  575  LYS GLY ASN TYR GLY LEU LEU ASP LEU ILE GLN ALA LEU
SEQRES  16 A  575  ARG TRP THR SER GLU ASN ILE GLY PHE PHE GLY GLY ASP
SEQRES  17 A  575  PRO LEU ARG ILE THR VAL PHE GLY SER GLY ALA GLY GLY
SEQRES  18 A  575  SER CYS VAL ASN LEU LEU THR LEU SER HIS TYR SER GLU
SEQRES  19 A  575  GLY LEU PHE GLN ARG ALA ILE ALA GLN SER GLY THR ALA
SEQRES  20 A  575  LEU SER SER TRP ALA VAL SER PHE GLN PRO ALA LYS TYR
SEQRES  21 A  575  ALA ARG MET LEU ALA THR LYS VAL GLY CYS ASN VAL SER
SEQRES  22 A  575  ASP THR VAL GLU LEU VAL GLU CYS LEU GLN LYS LYS PRO
SEQRES  23 A  575  TYR LYS GLU LEU VAL ASP GLN ASP ILE GLN PRO ALA ARG
SEQRES  24 A  575  TYR HIS ILE ALA PHE GLY PRO VAL ILE ASP GLY ASP VAL
SEQRES  25 A  575  ILE PRO ASP ASP PRO GLN ILE LEU MET GLU GLN GLY GLU
SEQRES  26 A  575  PHE LEU ASN TYR ASP ILE MET LEU GLY VAL ASN GLN GLY
SEQRES  27 A  575  GLU GLY LEU LYS PHE VAL GLU ASN ILE VAL ASP SER ASP
SEQRES  28 A  575  ASP GLY ILE SER ALA SER ASP PHE ASP PHE ALA VAL SER
SEQRES  29 A  575  ASN PHE VAL ASP ASN LEU TYR GLY TYR PRO GLU GLY LYS
SEQRES  30 A  575  ASP VAL LEU ARG GLU THR ILE LYS PHE MET TYR THR ASP
SEQRES  31 A  575  TRP ALA ASP ARG HIS ASN PRO GLU THR ARG ARG LYS THR
SEQRES  32 A  575  LEU LEU ALA LEU PHE THR ASP HIS GLN TRP VAL ALA PRO
SEQRES  33 A  575  ALA VAL ALA THR ALA ASP LEU HIS SER ASN PHE GLY SER
SEQRES  34 A  575  PRO THR TYR PHE TYR ALA PHE TYR HIS HIS CYS GLN THR
SEQRES  35 A  575  ASP GLN VAL PRO ALA TRP ALA ASP ALA ALA HIS GLY ASP
SEQRES  36 A  575  GLU VAL PRO TYR VAL LEU GLY ILE PRO MET ILE GLY PRO
SEQRES  37 A  575  THR GLU LEU PHE PRO CYS ASN PHE SER LYS ASN ASP VAL
SEQRES  38 A  575  MET LEU SER ALA VAL VAL MET THR TYR TRP THR ASN PHE
SEQRES  39 A  575  ALA LYS THR GLY ASP PRO ASN GLN PRO VAL PRO GLN ASP
SEQRES  40 A  575  THR LYS PHE ILE HIS THR LYS PRO ASN ARG PHE GLU GLU
SEQRES  41 A  575  VAL ALA TRP THR ARG TYR SER GLN LYS ASP GLN LEU TYR
SEQRES  42 A  575  LEU HIS ILE GLY LEU LYS PRO ARG VAL LYS GLU HIS TYR
SEQRES  43 A  575  ARG ALA ASN LYS VAL ASN LEU TRP LEU GLU LEU VAL PRO
SEQRES  44 A  575  HIS LEU HIS ASN LEU ASN ASP ARG THR LYS HIS HIS HIS
SEQRES  45 A  575  HIS HIS HIS
SEQRES   1 B  910  GLN GLY VAL TYR ALA PRO ALA GLN ALA GLN ILE ILE HIS
SEQRES   2 B  910  ALA GLY GLN ALA CYS VAL VAL LYS GLU ASP ASN ILE SER
SEQRES   3 B  910  GLU ARG VAL TYR THR ILE ARG GLU GLY ASP THR LEU VAL
SEQRES   4 B  910  LEU GLN CYS LEU VAL THR GLY HIS PRO ARG PRO GLN VAL
SEQRES   5 B  910  ARG TRP THR LYS THR ALA GLY SER ALA SER ASP LYS PHE
SEQRES   6 B  910  GLN GLU THR SER VAL LEU ASN GLU THR LEU ARG ILE GLU
SEQRES   7 B  910  LYS ILE GLN ARG LEU GLN GLY GLY ARG TYR TYR CYS LYS
SEQRES   8 B  910  ALA GLU ASN GLY VAL GLY VAL PRO ALA ILE LYS SER ILE
SEQRES   9 B  910  ARG VAL ASP VAL GLN TYR LEU ASP GLU PRO VAL LEU THR
SEQRES  10 B  910  VAL HIS GLN THR ILE SER ASP VAL ARG GLY SER PHE TYR
SEQRES  11 B  910  GLN GLU LYS THR VAL PHE LEU ARG CYS THR VAL ASN SER
SEQRES  12 B  910  ASN PRO PRO ALA ARG PHE ILE TRP LYS ARG GLY ALA GLU
SEQRES  13 B  910  THR LEU SER HIS SER GLN ASP ASN GLY VAL ASP ILE TYR
SEQRES  14 B  910  GLU PRO LEU TYR THR GLN GLY GLU THR LYS VAL LEU LYS
SEQRES  15 B  910  LEU LYS ASN LEU ARG PRO GLN ASP TYR ALA SER TYR THR
SEQRES  16 B  910  CYS GLN VAL SER VAL ARG ASN VAL CYS SER ILE PRO ASP
SEQRES  17 B  910  LYS SER ILE THR PHE GLN LEU THR ASN THR THR ALA PRO
SEQRES  18 B  910  PRO ALA LEU LYS LEU SER VAL ASN GLU THR LEU VAL VAL
SEQRES  19 B  910  ASN PRO GLY ASP ASN VAL THR MET GLN CYS SER LEU THR
SEQRES  20 B  910  GLY GLY ASP PRO GLN PRO GLU VAL LEU TRP SER HIS SER
SEQRES  21 B  910  PRO GLY PRO LEU PRO PRO ASN SER LEU VAL GLN GLY GLY
SEQRES  22 B  910  ASN LEU THR ILE TRP ARG ILE ARG VAL GLU ASP SER GLY
SEQRES  23 B  910  TYR TYR ASN CYS THR ALA ILE ASN ASN VAL GLY ASN PRO
SEQRES  24 B  910  ALA LYS LYS THR VAL ASN LEU LEU VAL ARG SER MET LYS
SEQRES  25 B  910  ASN ALA THR PHE GLN ILE THR PRO ASP VAL ILE LYS GLU
SEQRES  26 B  910  SER GLU THR ILE GLN LEU GLY GLN ASP LEU LYS LEU SER
SEQRES  27 B  910  CYS HIS VAL ASP ALA VAL PRO GLN GLU LYS VAL VAL TYR
SEQRES  28 B  910  SER TRP TYR LYS ASN GLY LYS PRO ALA ARG PHE SER ASP
SEQRES  29 B  910  ARG LEU LEU ILE THR ARG ASN ASP PRO GLU LEU PRO PRO
SEQRES  30 B  910  VAL THR CYS SER LEU GLU ILE ILE ASP LEU ARG PHE SER
SEQRES  31 B  910  ASP TYR GLY THR TYR LEU CYS VAL ALA THR PHE GLN GLY
SEQRES  32 B  910  ALA PRO ILE PRO ASP LEU SER VAL GLU VAL ASN ILE SER
SEQRES  33 B  910  SER GLU THR VAL PRO PRO THR ILE SER VAL PRO LYS GLY
SEQRES  34 B  910  GLN SER THR ILE THR VAL ARG GLU GLY SER ARG ALA GLU
SEQRES  35 B  910  LEU GLN CYS GLU VAL ARG GLY LYS PRO LYS PRO PRO ILE
SEQRES  36 B  910  ILE TRP SER ARG VAL ASP LYS GLU THR PRO MET PRO SER
SEQRES  37 B  910  GLY THR MET THR VAL GLU THR TYR ASP GLY LYS LEU ARG
SEQRES  38 B  910  LEU GLU SER VAL SER ARG ASP MET SER GLY THR TYR LYS
SEQRES  39 B  910  CYS GLN THR ALA ARG TYR ASN GLY PHE ASN ILE ARG PRO
SEQRES  40 B  910  ARG GLU ALA LEU VAL GLN LEU ASN VAL GLN PHE PRO PRO
SEQRES  41 B  910  VAL VAL GLU PRO ALA PHE GLN ASP VAL ARG GLN GLY MET
SEQRES  42 B  910  GLY ARG SER VAL THR LEU ARG CYS THR MET LEU LYS GLY
SEQRES  43 B  910  SER PRO MET LYS VAL ALA THR SER VAL TRP ARG PHE ASN
SEQRES  44 B  910  GLY THR LEU LEU ALA GLN PRO PRO ALA GLU GLN GLN ASP
SEQRES  45 B  910  TYR SER GLU LEU LYS VAL ASP SER VAL SER ARG GLU THR
SEQRES  46 B  910  SER GLY SER TYR GLU CYS SER ILE SER ASN ASP VAL GLY
SEQRES  47 B  910  VAL SER ALA CYS LEU PHE GLN VAL SER ALA LYS ALA TYR
SEQRES  48 B  910  SER PRO GLU PHE TYR TYR ASP THR PRO ASN PRO THR LEU
SEQRES  49 B  910  SER GLN LYS GLN SER LYS ASN TYR SER TYR ILE LEU GLN
SEQRES  50 B  910  TRP THR GLN LYS GLU PRO ASP ALA VAL ASP PRO ILE LEU
SEQRES  51 B  910  LYS TYR ARG LEU GLU VAL ARG GLN LEU ALA GLN ARG ASN
SEQRES  52 B  910  THR ILE GLN THR PHE ILE PRO VAL GLN LYS MET GLU LYS
SEQRES  53 B  910  GLY LEU LEU LEU GLU HIS ILE LEU PRO ASN LEU LYS VAL
SEQRES  54 B  910  PRO GLN SER TYR GLU VAL ARG LEU THR PRO ILE THR SER
SEQRES  55 B  910  PHE GLY ALA GLY ASP MET ALA ALA ARG ILE ILE ARG TYR
SEQRES  56 B  910  MET GLU PRO ILE ASN TYR PRO SER PRO THR ASP ASN THR
SEQRES  57 B  910  CYS ARG PHE GLU ASP GLU LYS ILE CYS GLY PHE VAL GLN
SEQRES  58 B  910  ASP LYS MET ASP ASN PHE ASP TRP THR ARG GLN ASN ALA
SEQRES  59 B  910  LEU THR GLN ASN PRO LYS ARG THR VAL ASN THR GLY PRO
SEQRES  60 B  910  PRO THR ASP ILE SER GLY THR PRO GLU GLY TYR TYR MET
SEQRES  61 B  910  PHE ILE GLU ALA SER ARG PRO ARG VAL THR GLY ASP LYS
SEQRES  62 B  910  ALA ARG LEU ILE SER PRO LEU TYR ASN ILE THR ALA LYS
SEQRES  63 B  910  TYR TYR CYS VAL SER PHE TYR TYR HIS MET TYR GLY LYS
SEQRES  64 B  910  HIS ILE GLY SER LEU ASN LEU LEU VAL ARG VAL ARG ASN
SEQRES  65 B  910  LYS ARG ALA ILE ASP THR GLN VAL TRP SER LEU SER GLY
SEQRES  66 B  910  ASN ARG GLY ASN MET TRP GLN GLN ALA HIS VAL PRO ILE
SEQRES  67 B  910  ASN PRO PRO GLY PRO PHE GLN ILE ILE PHE GLU GLY VAL
SEQRES  68 B  910  ARG GLY THR SER TYR GLU GLY ASP ILE ALA ILE ASP ASP
SEQRES  69 B  910  VAL THR LEU LYS LYS GLY ASP CYS PRO ARG LYS PRO ILE
SEQRES  70 B  910  GLY PRO ASN LYS GLY THR LYS HIS HIS HIS HIS HIS HIS
HET    NAG  B1001      14
HET    NAG  B1002      14
HET    NAG  B1003      14
HET    NAG  B1004      14
HET    BMA  B1005      11
HET    NAG  B1006      14
HET    NAG  B1007      14
HET    NAG  B1008      14
HET    NAG  B1009      14
HET    NAG  B1010      14
HET    NAG  B1011      14
HETNAM     NAG N-ACETYL-D-GLUCOSAMINE
HETNAM     BMA BETA-D-MANNOSE
FORMUL   3  NAG    10(C8 H15 N O6)
FORMUL   5  BMA    C6 H12 O6
HELIX    1 AA1 THR A   90  ARG A   94  5                                   5
HELIX    2 AA2 PRO A  132  ASN A  137  1                                   6
HELIX    3 AA3 ASN A  138  VAL A  146  1                                   9
HELIX    4 AA4 THR A  205  TYR A  209  5                                   5
HELIX    5 AA5 GLY A  211  ASN A  219  1                                   9
HELIX    6 AA6 LEU A  229  LEU A  235  1                                   7
HELIX    7 AA7 ASN A  245  ILE A  262  1                                  18
HELIX    8 AA8 GLY A  263  PHE A  265  5                                   3
HELIX    9 AA9 GLY A  278  LEU A  289  1                                  12
HELIX   10 AB1 SER A  290  GLU A  294  5                                   5
HELIX   11 AB2 GLN A  325  GLY A  338  1                                  14
HELIX   12 AB3 ASP A  343  GLN A  352  1                                  10
HELIX   13 AB4 PRO A  355  ASP A  361  1                                   7
HELIX   14 AB5 ASP A  385  GLN A  392  1                                   8
HELIX   15 AB6 GLY A  409  ASN A  415  1                                   7
HELIX   16 AB7 SER A  424  TYR A  440  1                                  17
HELIX   17 AB8 GLY A  445  TYR A  457  1                                  13
HELIX   18 AB9 ASN A  465  TRP A  482  1                                  18
HELIX   19 AC1 TRP A  482  PHE A  496  1                                  15
HELIX   20 AC2 GLU A  525  LEU A  530  1                                   6
HELIX   21 AC3 GLY A  531  GLY A  536  5                                   6
HELIX   22 AC4 SER A  546  GLY A  567  1                                  22
HELIX   23 AC5 ARG A  616  GLU A  625  1                                  10
HELIX   24 AC6 GLU A  625  LEU A  630  1                                   6
HELIX   25 AC7 ARG B  205  TYR B  209  5                                   5
HELIX   26 AC8 ASN B  220  ILE B  224  5                                   5
HELIX   27 AC9 ARG B  299  SER B  303  5                                   5
HELIX   28 AD1 PRO B  363  GLU B  365  5                                   3
HELIX   29 AD2 ARG B  406  TYR B  410  5                                   5
HELIX   30 AD3 SER B  504  SER B  508  5                                   5
HELIX   31 AD4 GLU B  660  VAL B  664  5                                   5
SHEET    1 AA1 3 LEU A  54  THR A  57  0
SHEET    2 AA1 3 GLY A  60  ARG A  63 -1  O  GLY A  60   N  THR A  57
SHEET    3 AA1 3 ILE A 107  ASN A 109  1  O  ARG A 108   N  ARG A  63
SHEET    1 AA211 ILE A  65  LYS A  67  0
SHEET    2 AA211 VAL A  77  PRO A  84 -1  O  VAL A  77   N  LYS A  67
SHEET    3 AA211 TYR A 155  PRO A 161 -1  O  VAL A 160   N  ILE A  78
SHEET    4 AA211 ILE A 221  VAL A 225 -1  O  VAL A 222   N  TYR A 159
SHEET    5 AA211 LYS A 190  TYR A 195  1  N  MET A 193   O  ILE A 221
SHEET    6 AA211 GLY A 267  SER A 277  1  O  THR A 273   N  VAL A 192
SHEET    7 AA211 ARG A 308  GLN A 312  1  O  ILE A 310   N  VAL A 274
SHEET    8 AA211 ASP A 399  ASN A 405  1  O  MET A 401   N  ALA A 311
SHEET    9 AA211 THR A 500  PHE A 505  1  O  PHE A 505   N  VAL A 404
SHEET   10 AA211 LEU A 601  ILE A 605  1  O  LEU A 603   N  PHE A 502
SHEET   11 AA211 ARG A 610  GLU A 613 -1  O  LYS A 612   N  TYR A 602
SHEET    1 AA3 3 ALA B  23  GLY B  33  0
SHEET    2 AA3 3 LEU B  56  HIS B  65 -1  O  GLN B  59   N  ILE B  30
SHEET    3 AA3 3 THR B  92  ILE B  95 -1  O  LEU B  93   N  LEU B  58
SHEET    1 AA4 4 VAL B  47  ARG B  51  0
SHEET    2 AA4 4 ALA B 118  LEU B 129  1  O  ARG B 123   N  TYR B  48
SHEET    3 AA4 4 GLY B 104  GLU B 111 -1  N  ALA B 110   O  ALA B 118
SHEET    4 AA4 4 GLN B  69  THR B  75 -1  N  GLN B  69   O  GLU B 111
SHEET    1 AA5 3 VAL B  47  ARG B  51  0
SHEET    2 AA5 3 ALA B 118  LEU B 129  1  O  ARG B 123   N  TYR B  48
SHEET    3 AA5 3 SER B 161  ASN B 162 -1  O  ASN B 162   N  TYR B 128
SHEET    1 AA6 4 VAL B 133  HIS B 137  0
SHEET    2 AA6 4 VAL B 153  THR B 158 -1  O  THR B 158   N  VAL B 133
SHEET    3 AA6 4 THR B 196  LEU B 201 -1  O  LYS B 197   N  CYS B 157
SHEET    4 AA6 4 ASP B 185  TYR B 187 -1  N  ASP B 185   O  LYS B 200
SHEET    1 AA7 3 ARG B 166  LYS B 170  0
SHEET    2 AA7 3 SER B 211  SER B 217 -1  O  SER B 217   N  ARG B 166
SHEET    3 AA7 3 LYS B 227  GLN B 232 -1  O  PHE B 231   N  TYR B 212
SHEET    1 AA8 4 ALA B 238  LEU B 244  0
SHEET    2 AA8 4 VAL B 258  ASP B 268 -1  O  ASP B 268   N  ALA B 238
SHEET    3 AA8 4 ASN B 292  ILE B 295 -1  O  LEU B 293   N  MET B 260
SHEET    4 AA8 4 SER B 286  VAL B 288 -1  N  LEU B 287   O  THR B 294
SHEET    1 AA9 4 THR B 249  VAL B 252  0
SHEET    2 AA9 4 ALA B 318  VAL B 326  1  O  LEU B 325   N  LEU B 250
SHEET    3 AA9 4 GLY B 304  ILE B 311 -1  N  CYS B 308   O  LYS B 320
SHEET    4 AA9 4 GLU B 272  SER B 278 -1  N  LEU B 274   O  THR B 309
SHEET    1 AB1 5 LEU B 385  ARG B 388  0
SHEET    2 AB1 5 CYS B 398  ILE B 402 -1  O  SER B 399   N  ARG B 388
SHEET    3 AB1 5 LEU B 353  ALA B 361 -1  N  LEU B 355   O  LEU B 400
SHEET    4 AB1 5 MET B 329  THR B 337 -1  N  LYS B 330   O  ASP B 360
SHEET    5 AB1 5 GLY B 520  PHE B 521  1  O  GLY B 520   N  ILE B 336
SHEET    1 AB2 3 VAL B 367  LYS B 373  0
SHEET    2 AB2 3 THR B 412  PHE B 419 -1  O  LEU B 414   N  TYR B 372
SHEET    3 AB2 3 LEU B 427  ASN B 432 -1  O  VAL B 431   N  TYR B 413
SHEET    1 AB3 2 VAL B 438  SER B 443  0
SHEET    2 AB3 2 GLU B 464  LYS B 468 -1  O  ARG B 466   N  THR B 441
SHEET    1 AB4 5 THR B 450  ARG B 454  0
SHEET    2 AB4 5 GLU B 527  GLU B 541  1  O  GLN B 535   N  VAL B 453
SHEET    3 AB4 5 GLY B 509  THR B 515 -1  N  GLY B 509   O  LEU B 532
SHEET    4 AB4 5 ILE B 473  ARG B 477 -1  N  SER B 476   O  LYS B 512
SHEET    5 AB4 5 VAL B 491  THR B 493 -1  O  THR B 493   N  ILE B 473
SHEET    1 AB5 4 THR B 450  ARG B 454  0
SHEET    2 AB5 4 GLU B 527  GLU B 541  1  O  GLN B 535   N  VAL B 453
SHEET    3 AB5 4 VAL B 555  SER B 565 -1  O  THR B 560   N  GLU B 541
SHEET    4 AB5 4 TYR B 591  VAL B 596 -1  O  LEU B 594   N  LEU B 557
SHEET    1 AB6 2 ALA B 459  GLN B 462  0
SHEET    2 AB6 2 LYS B 497  LEU B 500 -1  O  LEU B 500   N  ALA B 459
SHEET    1 AB7 5 PHE B 544  ARG B 548  0
SHEET    2 AB7 5 VAL B 617  SER B 625  1  O  GLN B 623   N  VAL B 547
SHEET    3 AB7 5 GLY B 605  SER B 612 -1  N  GLY B 605   O  VAL B 624
SHEET    4 AB7 5 THR B 571  PHE B 576 -1  N  VAL B 573   O  SER B 610
SHEET    5 AB7 5 THR B 579  LEU B 580 -1  O  THR B 579   N  PHE B 576
SHEET    1 AB8 3 PRO B 631  PHE B 633  0
SHEET    2 AB8 3 ASN B 649  GLN B 658 -1  O  THR B 657   N  GLU B 632
SHEET    3 AB8 3 PRO B 640  LEU B 642 -1  N  THR B 641   O  SER B 651
SHEET    1 AB9 3 PRO B 631  PHE B 633  0
SHEET    2 AB9 3 ASN B 649  GLN B 658 -1  O  THR B 657   N  GLU B 632
SHEET    3 AB9 3 LEU B 698  LYS B 706 -1  O  LEU B 698   N  TRP B 656
SHEET    1 AC1 4 ILE B 683  PRO B 688  0
SHEET    2 AC1 4 LYS B 669  ARG B 675 -1  N  TYR B 670   O  ILE B 687
SHEET    3 AC1 4 SER B 710  THR B 719 -1  O  THR B 716   N  ARG B 671
SHEET    4 AC1 4 GLY B 722  ALA B 723 -1  O  GLY B 722   N  THR B 719
SHEET    1 AC2 4 ILE B 683  PRO B 688  0
SHEET    2 AC2 4 LYS B 669  ARG B 675 -1  N  TYR B 670   O  ILE B 687
SHEET    3 AC2 4 SER B 710  THR B 719 -1  O  THR B 716   N  ARG B 671
SHEET    4 AC2 4 ALA B 727  ARG B 732 -1  O  ARG B 729   N  VAL B 713
SSBOND   1 CYS A  117    CYS A  153                          1555   1555  2.03
SSBOND   2 CYS A  339    CYS A  350                          1555   1555  2.03
SSBOND   3 CYS A  509    CYS A  543                          1555   1555  2.03
SSBOND   4 CYS B   36    CYS B  222                          1555   1555  2.03
SSBOND   5 CYS B   60    CYS B  108                          1555   1555  2.03
SSBOND   6 CYS B  157    CYS B  214                          1555   1555  2.04
SSBOND   7 CYS B  262    CYS B  308                          1555   1555  2.03
SSBOND   8 CYS B  357    CYS B  415                          1555   1555  2.03
SSBOND   9 CYS B  463    CYS B  513                          1555   1555  2.04
SSBOND  10 CYS B  559    CYS B  620                          1555   1555  2.03
LINK         ND2 ASN B  90                 C1  NAG B1009     1555   1555  1.44
LINK         ND2 ASN B 235                 C1  NAG B1007     1555   1555  1.44
LINK         ND2 ASN B 257                 C1  NAG B1001     1555   1555  1.44
LINK         ND2 ASN B 292                 C1  NAG B1011     1555   1555  1.43
LINK         ND2 ASN B 307                 C1  NAG B1002     1555   1555  1.44
LINK         ND2 ASN B 331                 C1  NAG B1003     1555   1555  1.44
LINK         ND2 ASN B 432                 C1  NAG B1008     1555   1555  1.44
LINK         ND2 ASN B 577                 C1  NAG B1010     1555   1555  1.44
LINK         ND2 ASN B 649                 C1  NAG B1006     1555   1555  1.44
LINK         O4  NAG B1003                 C1  NAG B1004     1555   1555  1.44
LINK         O4  NAG B1004                 C1  BMA B1005     1555   1555  1.44
CISPEP   1 GLN A  571    PRO A  572          0        -0.61
CISPEP   2 HIS B   65    PRO B   66          0        -0.71
CISPEP   3 ASN B  162    PRO B  163          0        -1.96
CISPEP   4 ASP B  268    PRO B  269          0         0.51
CISPEP   5 SER B  278    PRO B  279          0        -0.50
CISPEP   6 PRO B  283    PRO B  284          0        -0.36
CISPEP   7 LYS B  468    PRO B  469          0        -2.83
CISPEP   8 GLU B  541    PRO B  542          0         1.88
CISPEP   9 SER B  565    PRO B  566          0         1.93
SITE     1 AC1  5 GLN A 147  LYS A 357  LEU B  89  ASN B  90
SITE     2 AC1  5 THR B  92
SITE     1 AC2  3 ASN B 235  LYS B 627  NAG B1010
SITE     1 AC3  5 ASN B 257  TRP B 296  SER B 643  SER B 651
SITE     2 AC3  5 NAG B1006
SITE     1 AC4  8 GLN B 261  LEU B 287  GLN B 289  ASN B 292
SITE     2 AC4  8 THR B 294  TRP B 296  HIS B 700  ILE B 701
SITE     1 AC5  4 SER B 276  HIS B 277  SER B 278  ASN B 307
SITE     1 AC6  6 ASN B 331  THR B 333  GLN B 335  HIS B 358
SITE     2 AC6  6 PRO B 394  TYR B 518
SITE     1 AC7  3 THR B 412  GLU B 430  ASN B 432
SITE     1 AC8  5 PHE B 576  ASN B 577  GLU B 602  SER B 604
SITE     2 AC8  5 NAG B1007
SITE     1 AC9  4 SER B 647  ASN B 649  LYS B 706  NAG B1001
CRYST1  109.420  184.140   96.470  90.00  90.00  90.00 P 21 21 2     4
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.009139  0.000000  0.000000        0.00000
SCALE2      0.000000  0.005431  0.000000        0.00000
SCALE3      0.000000  0.000000  0.010366        0.00000
TER    4279      LEU A 633
TER    9661      MET B 734
MASTER      602    0   11   31   79    0   14    6 9810    2  180  115
END