longtext: 5tne-pdb

content
HEADER    HYDROLASE                               14-OCT-16   5TNE
TITLE     CRYSTAL STRUCTURE OF THE E153Q MUTANT OF THE CFTR INHIBITORY FACTOR
TITLE    2 CIF CONTAINING THE ADDUCTED CIS-STILBENE OXIDE HYDROLYSIS
TITLE    3 INTERMEDIATE
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: CFTR INHIBITORY FACTOR;
COMPND   3 CHAIN: A, B, C, D;
COMPND   4 ENGINEERED: YES;
COMPND   5 MUTATION: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: PSEUDOMONAS AERUGINOSA (STRAIN UCBPP-PA14);
SOURCE   3 ORGANISM_TAXID: 208963;
SOURCE   4 STRAIN: UCBPP-PA14;
SOURCE   5 GENE: PA14_26090;
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: TOP10
KEYWDS    EPOXIDE HYDROLASE, HYDROXYALKYL-ENZYME INTERMEDIATE, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    K.L.HVORECNY,D.R.MADDEN
REVDAT   1   11-OCT-17 5TNE    0
JRNL        AUTH   K.L.HVORECNY,C.D.BAHL,S.KITAMURA,K.S.S.LEE,B.D.HAMMOCK,
JRNL        AUTH 2 C.MORISSEAU,D.R.MADDEN
JRNL        TITL   ACTIVE-SITE FLEXIBILITY AND SUBSTRATE SPECIFICITY IN A
JRNL        TITL 2 BACTERIAL VIRULENCE FACTOR: CRYSTALLOGRAPHIC SNAPSHOTS OF AN
JRNL        TITL 3 EPOXIDE HYDROLASE.
JRNL        REF    STRUCTURE                     V.  25   697 2017
JRNL        REFN                   ISSN 1878-4186
JRNL        PMID   28392259
JRNL        DOI    10.1016/J.STR.2017.03.002
REMARK   2
REMARK   2 RESOLUTION.    1.75 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.10_2155
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : NULL
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.75
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 36.55
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.990
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.9
REMARK   3   NUMBER OF REFLECTIONS             : 122201
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.152
REMARK   3   R VALUE            (WORKING SET) : 0.150
REMARK   3   FREE R VALUE                     : 0.184
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.980
REMARK   3   FREE R VALUE TEST SET COUNT      : 6090
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 36.5618 -  5.4319    0.99     3895   305  0.1565 0.1646
REMARK   3     2  5.4319 -  4.3137    1.00     4115     0  0.1216 0.0000
REMARK   3     3  4.3137 -  3.7690    1.00     3802   304  0.1284 0.1444
REMARK   3     4  3.7690 -  3.4247    1.00     3801   305  0.1331 0.1516
REMARK   3     5  3.4247 -  3.1794    1.00     4093     0  0.1399 0.0000
REMARK   3     6  3.1794 -  2.9920    1.00     3766   305  0.1546 0.1868
REMARK   3     7  2.9920 -  2.8422    1.00     3771   305  0.1582 0.1952
REMARK   3     8  2.8422 -  2.7186    1.00     4087     0  0.1512 0.0000
REMARK   3     9  2.7186 -  2.6139    1.00     3770   303  0.1518 0.1737
REMARK   3    10  2.6139 -  2.5238    1.00     3766   304  0.1530 0.1917
REMARK   3    11  2.5238 -  2.4449    1.00     4103     0  0.1559 0.0000
REMARK   3    12  2.4449 -  2.3750    1.00     3744   305  0.1559 0.1955
REMARK   3    13  2.3750 -  2.3125    1.00     3779   305  0.1479 0.1852
REMARK   3    14  2.3125 -  2.2561    1.00     4060     0  0.1512 0.0000
REMARK   3    15  2.2561 -  2.2048    1.00     3761   305  0.1501 0.1948
REMARK   3    16  2.2048 -  2.1579    1.00     3756   302  0.1553 0.1799
REMARK   3    17  2.1579 -  2.1147    1.00     4069     0  0.1521 0.0000
REMARK   3    18  2.1147 -  2.0748    1.00     3722   305  0.1492 0.2093
REMARK   3    19  2.0748 -  2.0378    1.00     3735   305  0.1541 0.1887
REMARK   3    20  2.0378 -  2.0032    1.00     4110     0  0.1600 0.0000
REMARK   3    21  2.0032 -  1.9709    1.00     3775   304  0.1593 0.1978
REMARK   3    22  1.9709 -  1.9406    1.00     3718   305  0.1609 0.2058
REMARK   3    23  1.9406 -  1.9120    1.00     4031     0  0.1591 0.0000
REMARK   3    24  1.9120 -  1.8851    1.00     3786   305  0.1661 0.2002
REMARK   3    25  1.8851 -  1.8596    1.00     3731   304  0.1784 0.2325
REMARK   3    26  1.8596 -  1.8355    1.00     4084     0  0.1888 0.0000
REMARK   3    27  1.8355 -  1.8125    1.00     3774   305  0.1876 0.2580
REMARK   3    28  1.8125 -  1.7907    1.00     3725   305  0.1914 0.2385
REMARK   3    29  1.7907 -  1.7699    1.00     3983     0  0.1931 0.0000
REMARK   3    30  1.7699 -  1.7500    1.00     3799   304  0.1922 0.2413
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : NULL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.170
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 18.000
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.006           9928
REMARK   3   ANGLE     :  0.807          13513
REMARK   3   CHIRALITY :  0.053           1391
REMARK   3   PLANARITY :  0.006           1779
REMARK   3   DIHEDRAL  : 14.454           5855
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 4
REMARK   3   TLS GROUP : 1
REMARK   3    SELECTION: (CHAIN A AND RESID 25:321)
REMARK   3    ORIGIN FOR THE GROUP (A):  21.8782  12.1967 -27.2866
REMARK   3    T TENSOR
REMARK   3      T11:   0.0955 T22:   0.1013
REMARK   3      T33:   0.0970 T12:  -0.0025
REMARK   3      T13:   0.0012 T23:  -0.0108
REMARK   3    L TENSOR
REMARK   3      L11:   0.7450 L22:   0.6402
REMARK   3      L33:   0.7303 L12:  -0.0693
REMARK   3      L13:   0.0768 L23:   0.0197
REMARK   3    S TENSOR
REMARK   3      S11:   0.0177 S12:   0.0753 S13:  -0.0799
REMARK   3      S21:  -0.0531 S22:  -0.0240 S23:  -0.0411
REMARK   3      S31:   0.0885 S32:   0.0320 S33:   0.0067
REMARK   3   TLS GROUP : 2
REMARK   3    SELECTION: (CHAIN B AND RESID 25:320)
REMARK   3    ORIGIN FOR THE GROUP (A):  30.9218  51.6794 -15.5563
REMARK   3    T TENSOR
REMARK   3      T11:   0.0945 T22:   0.0941
REMARK   3      T33:   0.1504 T12:  -0.0164
REMARK   3      T13:  -0.0225 T23:  -0.0039
REMARK   3    L TENSOR
REMARK   3      L11:   0.9815 L22:   0.9229
REMARK   3      L33:   0.4853 L12:   0.3269
REMARK   3      L13:   0.0214 L23:   0.1835
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0183 S12:  -0.0026 S13:   0.1332
REMARK   3      S21:   0.0398 S22:   0.0205 S23:  -0.0765
REMARK   3      S31:  -0.0796 S32:   0.0342 S33:  -0.0022
REMARK   3   TLS GROUP : 3
REMARK   3    SELECTION: (CHAIN C AND RESID 25:321)
REMARK   3    ORIGIN FOR THE GROUP (A):  -5.8347  44.9214 -27.0694
REMARK   3    T TENSOR
REMARK   3      T11:   0.1012 T22:   0.0993
REMARK   3      T33:   0.1426 T12:  -0.0015
REMARK   3      T13:  -0.0015 T23:   0.0048
REMARK   3    L TENSOR
REMARK   3      L11:   0.6930 L22:   0.7285
REMARK   3      L33:   0.7016 L12:  -0.0412
REMARK   3      L13:   0.0411 L23:  -0.0376
REMARK   3    S TENSOR
REMARK   3      S11:   0.0145 S12:   0.0328 S13:   0.1217
REMARK   3      S21:  -0.0352 S22:  -0.0339 S23:   0.0664
REMARK   3      S31:  -0.0949 S32:  -0.0244 S33:   0.0198
REMARK   3   TLS GROUP : 4
REMARK   3    SELECTION: (CHAIN D AND RESID 25:320)
REMARK   3    ORIGIN FOR THE GROUP (A): -14.8340   5.3179 -15.6887
REMARK   3    T TENSOR
REMARK   3      T11:   0.0999 T22:   0.1115
REMARK   3      T33:   0.0924 T12:  -0.0231
REMARK   3      T13:   0.0021 T23:   0.0043
REMARK   3    L TENSOR
REMARK   3      L11:   0.8898 L22:   0.8432
REMARK   3      L33:   0.4424 L12:   0.1943
REMARK   3      L13:  -0.0818 L23:  -0.1351
REMARK   3    S TENSOR
REMARK   3      S11:   0.0102 S12:  -0.0437 S13:  -0.0532
REMARK   3      S21:   0.0076 S22:  -0.0070 S23:   0.0825
REMARK   3      S31:   0.0460 S32:  -0.0075 S33:  -0.0034
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 5TNE COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 17-OCT-16.
REMARK 100 THE DEPOSITION ID IS D_1000221150.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 20-APR-16
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : NSLS
REMARK 200  BEAMLINE                       : X6A
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9795
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 270
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS DEC 6, 2010
REMARK 200  DATA SCALING SOFTWARE          : XDS DEC 6, 2010
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 122215
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.750
REMARK 200  RESOLUTION RANGE LOW       (A) : 36.554
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.8
REMARK 200  DATA REDUNDANCY                : 3.940
REMARK 200  R MERGE                    (I) : 0.05700
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 19.6200
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.75
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.80
REMARK 200  COMPLETENESS FOR SHELL     (%) : 99.8
REMARK 200  DATA REDUNDANCY IN SHELL       : 3.91
REMARK 200  R MERGE FOR SHELL          (I) : 0.35700
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 4.530
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHENIX 1.7
REMARK 200 STARTING MODEL: 3KD2
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 45.48
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.26
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: SODIUM ACETATE, PH5 CALCIUM CHLORIDE
REMARK 280  PEG 8000, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 291K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 1 2 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y,-Z
REMARK 290       3555   X+1/2,Y+1/2,Z
REMARK 290       4555   -X+1/2,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   3  1.000000  0.000000  0.000000       83.97200
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       41.84500
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000       83.97200
REMARK 290   SMTRY2   4  0.000000  1.000000  0.000000       41.84500
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 2780 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 21050 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -22.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 2770 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 20880 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -22.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 375
REMARK 375 SPECIAL POSITION
REMARK 375 THE FOLLOWING ATOMS ARE FOUND TO BE WITHIN 0.15 ANGSTROMS
REMARK 375 OF A SYMMETRY RELATED ATOM AND ARE ASSUMED TO BE ON SPECIAL
REMARK 375 POSITIONS.
REMARK 375
REMARK 375 ATOM RES CSSEQI
REMARK 375      HOH D 627  LIES ON A SPECIAL POSITION.
REMARK 375      HOH D 684  LIES ON A SPECIAL POSITION.
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     HIS A   322
REMARK 465     HIS A   323
REMARK 465     HIS A   324
REMARK 465     HIS A   325
REMARK 465     HIS B   321
REMARK 465     HIS B   322
REMARK 465     HIS B   323
REMARK 465     HIS B   324
REMARK 465     HIS B   325
REMARK 465     HIS C   322
REMARK 465     HIS C   323
REMARK 465     HIS C   324
REMARK 465     HIS C   325
REMARK 465     HIS D   321
REMARK 465     HIS D   322
REMARK 465     HIS D   323
REMARK 465     HIS D   324
REMARK 465     HIS D   325
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   O    HOH C   720     O    HOH C   727              2.01
REMARK 500   O    HOH C   730     O    HOH C   750              2.04
REMARK 500   OE2  GLU C   189     O    HOH C   501              2.05
REMARK 500   OE2  GLU D   288     O    HOH D   401              2.07
REMARK 500   O    HOH B   599     O    HOH B   610              2.11
REMARK 500   OE2  GLU B    35     O    HOH B   401              2.16
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS
REMARK 500
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.
REMARK 500
REMARK 500 DISTANCE CUTOFF:
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE
REMARK 500   O    HOH A   705     O    HOH D   606     2555     2.18
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ASP A 129     -130.43     62.01
REMARK 500    ALA A 154      147.64   -177.03
REMARK 500    ALA A 253        0.13    -69.09
REMARK 500    CYS A 303       54.56   -142.11
REMARK 500    THR B  99      -69.03    -92.16
REMARK 500    ASP B 129     -131.93     58.73
REMARK 500    ALA B 154      144.18   -177.60
REMARK 500    ASP C 129     -129.99     61.67
REMARK 500    ALA C 154      149.25   -176.29
REMARK 500    ASP C 184     -179.80    -69.21
REMARK 500    CYS C 303       57.12   -141.47
REMARK 500    THR D  99      -67.77    -93.90
REMARK 500    ASP D 129     -132.08     56.58
REMARK 500    ALA D 154      146.80    179.31
REMARK 500    CYS D 303       53.61   -141.56
REMARK 500    ARG D 319      159.99     66.35
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH A 793        DISTANCE =  6.08 ANGSTROMS
REMARK 525    HOH C 796        DISTANCE =  6.15 ANGSTROMS
REMARK 525    HOH D 684        DISTANCE =  5.87 ANGSTROMS
REMARK 525    HOH D 685        DISTANCE =  6.76 ANGSTROMS
REMARK 600
REMARK 600 HETEROGEN
REMARK 600
REMARK 600 7F6 IS THE BOUND FORM ( COVALENTLY LINKED VIA OD1 ATOM OF ASP 129
REMARK 600 OF CIF) OF CIS-STILBENE EPOXIDE
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue 7F6 A 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Di-peptide 7F6 C 401 and ASP C
REMARK 800  129
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 3KD2   RELATED DB: PDB
REMARK 900 WILD TYPE VERSION OF THE CURRENT SUBMISSION
REMARK 900 RELATED ID: 4DMC   RELATED DB: PDB
REMARK 900 APO VERSION OF SAME PROTEIN AS CURRENT SUBMISSION (CIF WITH E153Q
REMARK 900 MUTATION)
REMARK 900 RELATED ID: 5TND   RELATED DB: PDB
REMARK 900 RELATED ID: 5TNF   RELATED DB: PDB
REMARK 900 RELATED ID: 5TNG   RELATED DB: PDB
REMARK 900 RELATED ID: 5TNH   RELATED DB: PDB
REMARK 900 RELATED ID: 5TNI   RELATED DB: PDB
REMARK 900 RELATED ID: 5TNJ   RELATED DB: PDB
REMARK 900 RELATED ID: 5TNK   RELATED DB: PDB
REMARK 900 RELATED ID: 5TNL   RELATED DB: PDB
REMARK 900 RELATED ID: 5TNM   RELATED DB: PDB
REMARK 900 RELATED ID: 5TNN   RELATED DB: PDB
REMARK 900 RELATED ID: 5TNP   RELATED DB: PDB
REMARK 900 RELATED ID: 5TNQ   RELATED DB: PDB
REMARK 900 RELATED ID: 5TNR   RELATED DB: PDB
REMARK 900 RELATED ID: 5TNS   RELATED DB: PDB
DBREF1 5TNE A   25   325  UNP                  A0A0M3KL26_PSEAB
DBREF2 5TNE A     A0A0M3KL26                          1         301
DBREF1 5TNE B   25   325  UNP                  A0A0M3KL26_PSEAB
DBREF2 5TNE B     A0A0M3KL26                          1         301
DBREF1 5TNE C   25   325  UNP                  A0A0M3KL26_PSEAB
DBREF2 5TNE C     A0A0M3KL26                          1         301
DBREF1 5TNE D   25   325  UNP                  A0A0M3KL26_PSEAB
DBREF2 5TNE D     A0A0M3KL26                          1         301
SEQADV 5TNE GLN A  153  UNP  A0A0M3KL2 GLU   129 ENGINEERED MUTATION
SEQADV 5TNE GLN B  153  UNP  A0A0M3KL2 GLU   129 ENGINEERED MUTATION
SEQADV 5TNE GLN C  153  UNP  A0A0M3KL2 GLU   129 ENGINEERED MUTATION
SEQADV 5TNE GLN D  153  UNP  A0A0M3KL2 GLU   129 ENGINEERED MUTATION
SEQRES   1 A  301  ALA GLU GLU PHE PRO VAL PRO ASN GLY PHE GLU SER ALA
SEQRES   2 A  301  TYR ARG GLU VAL ASP GLY VAL LYS LEU HIS TYR VAL LYS
SEQRES   3 A  301  GLY GLY GLN GLY PRO LEU VAL MET LEU VAL HIS GLY PHE
SEQRES   4 A  301  GLY GLN THR TRP TYR GLU TRP HIS GLN LEU MET PRO GLU
SEQRES   5 A  301  LEU ALA LYS ARG PHE THR VAL ILE ALA PRO ASP LEU PRO
SEQRES   6 A  301  GLY LEU GLY GLN SER GLU PRO PRO LYS THR GLY TYR SER
SEQRES   7 A  301  GLY GLU GLN VAL ALA VAL TYR LEU HIS LYS LEU ALA ARG
SEQRES   8 A  301  GLN PHE SER PRO ASP ARG PRO PHE ASP LEU VAL ALA HIS
SEQRES   9 A  301  ASP ILE GLY ILE TRP ASN THR TYR PRO MET VAL VAL LYS
SEQRES  10 A  301  ASN GLN ALA ASP ILE ALA ARG LEU VAL TYR MET GLN ALA
SEQRES  11 A  301  PRO ILE PRO ASP ALA ARG ILE TYR ARG PHE PRO ALA PHE
SEQRES  12 A  301  THR ALA GLN GLY GLU SER LEU VAL TRP HIS PHE SER PHE
SEQRES  13 A  301  PHE ALA ALA ASP ASP ARG LEU ALA GLU THR LEU ILE ALA
SEQRES  14 A  301  GLY LYS GLU ARG PHE PHE LEU GLU HIS PHE ILE LYS SER
SEQRES  15 A  301  HIS ALA SER ASN THR GLU VAL PHE SER GLU ARG LEU LEU
SEQRES  16 A  301  ASP LEU TYR ALA ARG SER TYR ALA LYS PRO HIS SER LEU
SEQRES  17 A  301  ASN ALA SER PHE GLU TYR TYR ARG ALA LEU ASN GLU SER
SEQRES  18 A  301  VAL ARG GLN ASN ALA GLU LEU ALA LYS THR ARG LEU GLN
SEQRES  19 A  301  MET PRO THR MET THR LEU ALA GLY GLY GLY HIS GLY GLY
SEQRES  20 A  301  MET GLY THR PHE GLN LEU GLU GLN MET LYS ALA TYR ALA
SEQRES  21 A  301  GLU ASP VAL GLU GLY HIS VAL LEU PRO GLY CYS GLY HIS
SEQRES  22 A  301  TRP LEU PRO GLU GLU CYS ALA ALA PRO MET ASN ARG LEU
SEQRES  23 A  301  VAL ILE ASP PHE LEU SER ARG GLY ARG HIS HIS HIS HIS
SEQRES  24 A  301  HIS HIS
SEQRES   1 B  301  ALA GLU GLU PHE PRO VAL PRO ASN GLY PHE GLU SER ALA
SEQRES   2 B  301  TYR ARG GLU VAL ASP GLY VAL LYS LEU HIS TYR VAL LYS
SEQRES   3 B  301  GLY GLY GLN GLY PRO LEU VAL MET LEU VAL HIS GLY PHE
SEQRES   4 B  301  GLY GLN THR TRP TYR GLU TRP HIS GLN LEU MET PRO GLU
SEQRES   5 B  301  LEU ALA LYS ARG PHE THR VAL ILE ALA PRO ASP LEU PRO
SEQRES   6 B  301  GLY LEU GLY GLN SER GLU PRO PRO LYS THR GLY TYR SER
SEQRES   7 B  301  GLY GLU GLN VAL ALA VAL TYR LEU HIS LYS LEU ALA ARG
SEQRES   8 B  301  GLN PHE SER PRO ASP ARG PRO PHE ASP LEU VAL ALA HIS
SEQRES   9 B  301  ASP ILE GLY ILE TRP ASN THR TYR PRO MET VAL VAL LYS
SEQRES  10 B  301  ASN GLN ALA ASP ILE ALA ARG LEU VAL TYR MET GLN ALA
SEQRES  11 B  301  PRO ILE PRO ASP ALA ARG ILE TYR ARG PHE PRO ALA PHE
SEQRES  12 B  301  THR ALA GLN GLY GLU SER LEU VAL TRP HIS PHE SER PHE
SEQRES  13 B  301  PHE ALA ALA ASP ASP ARG LEU ALA GLU THR LEU ILE ALA
SEQRES  14 B  301  GLY LYS GLU ARG PHE PHE LEU GLU HIS PHE ILE LYS SER
SEQRES  15 B  301  HIS ALA SER ASN THR GLU VAL PHE SER GLU ARG LEU LEU
SEQRES  16 B  301  ASP LEU TYR ALA ARG SER TYR ALA LYS PRO HIS SER LEU
SEQRES  17 B  301  ASN ALA SER PHE GLU TYR TYR ARG ALA LEU ASN GLU SER
SEQRES  18 B  301  VAL ARG GLN ASN ALA GLU LEU ALA LYS THR ARG LEU GLN
SEQRES  19 B  301  MET PRO THR MET THR LEU ALA GLY GLY GLY HIS GLY GLY
SEQRES  20 B  301  MET GLY THR PHE GLN LEU GLU GLN MET LYS ALA TYR ALA
SEQRES  21 B  301  GLU ASP VAL GLU GLY HIS VAL LEU PRO GLY CYS GLY HIS
SEQRES  22 B  301  TRP LEU PRO GLU GLU CYS ALA ALA PRO MET ASN ARG LEU
SEQRES  23 B  301  VAL ILE ASP PHE LEU SER ARG GLY ARG HIS HIS HIS HIS
SEQRES  24 B  301  HIS HIS
SEQRES   1 C  301  ALA GLU GLU PHE PRO VAL PRO ASN GLY PHE GLU SER ALA
SEQRES   2 C  301  TYR ARG GLU VAL ASP GLY VAL LYS LEU HIS TYR VAL LYS
SEQRES   3 C  301  GLY GLY GLN GLY PRO LEU VAL MET LEU VAL HIS GLY PHE
SEQRES   4 C  301  GLY GLN THR TRP TYR GLU TRP HIS GLN LEU MET PRO GLU
SEQRES   5 C  301  LEU ALA LYS ARG PHE THR VAL ILE ALA PRO ASP LEU PRO
SEQRES   6 C  301  GLY LEU GLY GLN SER GLU PRO PRO LYS THR GLY TYR SER
SEQRES   7 C  301  GLY GLU GLN VAL ALA VAL TYR LEU HIS LYS LEU ALA ARG
SEQRES   8 C  301  GLN PHE SER PRO ASP ARG PRO PHE ASP LEU VAL ALA HIS
SEQRES   9 C  301  ASP ILE GLY ILE TRP ASN THR TYR PRO MET VAL VAL LYS
SEQRES  10 C  301  ASN GLN ALA ASP ILE ALA ARG LEU VAL TYR MET GLN ALA
SEQRES  11 C  301  PRO ILE PRO ASP ALA ARG ILE TYR ARG PHE PRO ALA PHE
SEQRES  12 C  301  THR ALA GLN GLY GLU SER LEU VAL TRP HIS PHE SER PHE
SEQRES  13 C  301  PHE ALA ALA ASP ASP ARG LEU ALA GLU THR LEU ILE ALA
SEQRES  14 C  301  GLY LYS GLU ARG PHE PHE LEU GLU HIS PHE ILE LYS SER
SEQRES  15 C  301  HIS ALA SER ASN THR GLU VAL PHE SER GLU ARG LEU LEU
SEQRES  16 C  301  ASP LEU TYR ALA ARG SER TYR ALA LYS PRO HIS SER LEU
SEQRES  17 C  301  ASN ALA SER PHE GLU TYR TYR ARG ALA LEU ASN GLU SER
SEQRES  18 C  301  VAL ARG GLN ASN ALA GLU LEU ALA LYS THR ARG LEU GLN
SEQRES  19 C  301  MET PRO THR MET THR LEU ALA GLY GLY GLY HIS GLY GLY
SEQRES  20 C  301  MET GLY THR PHE GLN LEU GLU GLN MET LYS ALA TYR ALA
SEQRES  21 C  301  GLU ASP VAL GLU GLY HIS VAL LEU PRO GLY CYS GLY HIS
SEQRES  22 C  301  TRP LEU PRO GLU GLU CYS ALA ALA PRO MET ASN ARG LEU
SEQRES  23 C  301  VAL ILE ASP PHE LEU SER ARG GLY ARG HIS HIS HIS HIS
SEQRES  24 C  301  HIS HIS
SEQRES   1 D  301  ALA GLU GLU PHE PRO VAL PRO ASN GLY PHE GLU SER ALA
SEQRES   2 D  301  TYR ARG GLU VAL ASP GLY VAL LYS LEU HIS TYR VAL LYS
SEQRES   3 D  301  GLY GLY GLN GLY PRO LEU VAL MET LEU VAL HIS GLY PHE
SEQRES   4 D  301  GLY GLN THR TRP TYR GLU TRP HIS GLN LEU MET PRO GLU
SEQRES   5 D  301  LEU ALA LYS ARG PHE THR VAL ILE ALA PRO ASP LEU PRO
SEQRES   6 D  301  GLY LEU GLY GLN SER GLU PRO PRO LYS THR GLY TYR SER
SEQRES   7 D  301  GLY GLU GLN VAL ALA VAL TYR LEU HIS LYS LEU ALA ARG
SEQRES   8 D  301  GLN PHE SER PRO ASP ARG PRO PHE ASP LEU VAL ALA HIS
SEQRES   9 D  301  ASP ILE GLY ILE TRP ASN THR TYR PRO MET VAL VAL LYS
SEQRES  10 D  301  ASN GLN ALA ASP ILE ALA ARG LEU VAL TYR MET GLN ALA
SEQRES  11 D  301  PRO ILE PRO ASP ALA ARG ILE TYR ARG PHE PRO ALA PHE
SEQRES  12 D  301  THR ALA GLN GLY GLU SER LEU VAL TRP HIS PHE SER PHE
SEQRES  13 D  301  PHE ALA ALA ASP ASP ARG LEU ALA GLU THR LEU ILE ALA
SEQRES  14 D  301  GLY LYS GLU ARG PHE PHE LEU GLU HIS PHE ILE LYS SER
SEQRES  15 D  301  HIS ALA SER ASN THR GLU VAL PHE SER GLU ARG LEU LEU
SEQRES  16 D  301  ASP LEU TYR ALA ARG SER TYR ALA LYS PRO HIS SER LEU
SEQRES  17 D  301  ASN ALA SER PHE GLU TYR TYR ARG ALA LEU ASN GLU SER
SEQRES  18 D  301  VAL ARG GLN ASN ALA GLU LEU ALA LYS THR ARG LEU GLN
SEQRES  19 D  301  MET PRO THR MET THR LEU ALA GLY GLY GLY HIS GLY GLY
SEQRES  20 D  301  MET GLY THR PHE GLN LEU GLU GLN MET LYS ALA TYR ALA
SEQRES  21 D  301  GLU ASP VAL GLU GLY HIS VAL LEU PRO GLY CYS GLY HIS
SEQRES  22 D  301  TRP LEU PRO GLU GLU CYS ALA ALA PRO MET ASN ARG LEU
SEQRES  23 D  301  VAL ILE ASP PHE LEU SER ARG GLY ARG HIS HIS HIS HIS
SEQRES  24 D  301  HIS HIS
HET    7F6  A 401      15
HET    7F6  C 401      15
HETNAM     7F6 (1R,2R)-1,2-DIPHENYLETHANE-1,2-DIOL
HETSYN     7F6 CIS-STILBENE EPOXIDE, BOUND FORM
FORMUL   5  7F6    2(C14 H14 O2)
FORMUL   7  HOH   *1112(H2 O)
HELIX    1 AA1 THR A   66  HIS A   71  5                                   6
HELIX    2 AA2 LEU A   73  ALA A   78  1                                   6
HELIX    3 AA3 SER A  102  SER A  118  1                                  17
HELIX    4 AA4 ASP A  129  ASN A  134  1                                   6
HELIX    5 AA5 THR A  135  ASN A  142  1                                   8
HELIX    6 AA6 ASP A  158  PHE A  164  5                                   7
HELIX    7 AA7 TRP A  176  ALA A  183  1                                   8
HELIX    8 AA8 ARG A  186  ALA A  193  1                                   8
HELIX    9 AA9 LYS A  195  HIS A  207  1                                  13
HELIX   10 AB1 ASN A  210  PHE A  214  5                                   5
HELIX   11 AB2 SER A  215  ALA A  227  1                                  13
HELIX   12 AB3 LYS A  228  ALA A  241  1                                  14
HELIX   13 AB4 ALA A  241  ALA A  253  1                                  13
HELIX   14 AB5 THR A  274  ALA A  284  1                                  11
HELIX   15 AB6 TRP A  298  CYS A  303  1                                   6
HELIX   16 AB7 CYS A  303  ARG A  317  1                                  15
HELIX   17 AB8 THR B   66  HIS B   71  5                                   6
HELIX   18 AB9 GLN B   72  ALA B   78  1                                   7
HELIX   19 AC1 SER B  102  SER B  118  1                                  17
HELIX   20 AC2 ASP B  129  ASN B  134  1                                   6
HELIX   21 AC3 THR B  135  ASN B  142  1                                   8
HELIX   22 AC4 ASP B  158  PHE B  164  5                                   7
HELIX   23 AC5 TRP B  176  ALA B  183  1                                   8
HELIX   24 AC6 ARG B  186  ALA B  193  1                                   8
HELIX   25 AC7 LYS B  195  HIS B  207  1                                  13
HELIX   26 AC8 ASN B  210  PHE B  214  5                                   5
HELIX   27 AC9 SER B  215  LYS B  228  1                                  14
HELIX   28 AD1 LYS B  228  ALA B  241  1                                  14
HELIX   29 AD2 ALA B  241  ALA B  253  1                                  13
HELIX   30 AD3 THR B  274  ALA B  284  1                                  11
HELIX   31 AD4 TRP B  298  CYS B  303  1                                   6
HELIX   32 AD5 CYS B  303  ARG B  317  1                                  15
HELIX   33 AD6 THR C   66  HIS C   71  5                                   6
HELIX   34 AD7 LEU C   73  ALA C   78  1                                   6
HELIX   35 AD8 SER C  102  SER C  118  1                                  17
HELIX   36 AD9 ASP C  129  ASN C  134  1                                   6
HELIX   37 AE1 THR C  135  ASN C  142  1                                   8
HELIX   38 AE2 ASP C  158  PHE C  164  5                                   7
HELIX   39 AE3 VAL C  175  ALA C  183  1                                   9
HELIX   40 AE4 ARG C  186  ALA C  193  1                                   8
HELIX   41 AE5 LYS C  195  HIS C  207  1                                  13
HELIX   42 AE6 ASN C  210  PHE C  214  5                                   5
HELIX   43 AE7 SER C  215  ALA C  227  1                                  13
HELIX   44 AE8 LYS C  228  ALA C  241  1                                  14
HELIX   45 AE9 ALA C  241  ALA C  253  1                                  13
HELIX   46 AF1 THR C  274  ALA C  282  1                                   9
HELIX   47 AF2 TRP C  298  CYS C  303  1                                   6
HELIX   48 AF3 CYS C  303  SER C  316  1                                  14
HELIX   49 AF4 THR D   66  HIS D   71  5                                   6
HELIX   50 AF5 GLN D   72  ALA D   78  1                                   7
HELIX   51 AF6 SER D  102  SER D  118  1                                  17
HELIX   52 AF7 ASP D  129  ASN D  134  1                                   6
HELIX   53 AF8 THR D  135  ASN D  142  1                                   8
HELIX   54 AF9 ASP D  158  PHE D  164  5                                   7
HELIX   55 AG1 TRP D  176  ALA D  183  1                                   8
HELIX   56 AG2 ARG D  186  ALA D  193  1                                   8
HELIX   57 AG3 LYS D  195  HIS D  207  1                                  13
HELIX   58 AG4 ASN D  210  PHE D  214  5                                   5
HELIX   59 AG5 SER D  215  ALA D  227  1                                  13
HELIX   60 AG6 LYS D  228  ALA D  241  1                                  14
HELIX   61 AG7 ALA D  241  ALA D  253  1                                  13
HELIX   62 AG8 THR D  274  ALA D  282  1                                   9
HELIX   63 AG9 TRP D  298  CYS D  303  1                                   6
HELIX   64 AH1 CYS D  303  ARG D  317  1                                  15
SHEET    1 AA1 8 GLU A  35  VAL A  41  0
SHEET    2 AA1 8 VAL A  44  GLY A  52 -1  O  VAL A  44   N  VAL A  41
SHEET    3 AA1 8 THR A  82  PRO A  86 -1  O  VAL A  83   N  GLY A  51
SHEET    4 AA1 8 LEU A  56  VAL A  60  1  N  VAL A  57   O  THR A  82
SHEET    5 AA1 8 PHE A 123  HIS A 128  1  O  VAL A 126   N  VAL A  60
SHEET    6 AA1 8 ILE A 146  MET A 152  1  O  VAL A 150   N  LEU A 125
SHEET    7 AA1 8 THR A 261  GLY A 266  1  O  MET A 262   N  TYR A 151
SHEET    8 AA1 8 VAL A 287  LEU A 292  1  O  LEU A 292   N  ALA A 265
SHEET    1 AA2 8 PHE B  34  VAL B  41  0
SHEET    2 AA2 8 VAL B  44  GLY B  52 -1  O  LEU B  46   N  ARG B  39
SHEET    3 AA2 8 THR B  82  PRO B  86 -1  O  VAL B  83   N  GLY B  51
SHEET    4 AA2 8 LEU B  56  VAL B  60  1  N  VAL B  57   O  THR B  82
SHEET    5 AA2 8 PHE B 123  HIS B 128  1  O  ASP B 124   N  LEU B  56
SHEET    6 AA2 8 ILE B 146  MET B 152  1  O  ALA B 147   N  PHE B 123
SHEET    7 AA2 8 THR B 261  GLY B 266  1  O  MET B 262   N  LEU B 149
SHEET    8 AA2 8 VAL B 287  LEU B 292  1  O  LEU B 292   N  ALA B 265
SHEET    1 AA3 2 PHE B 167  THR B 168  0
SHEET    2 AA3 2 GLY B 171  GLU B 172 -1  O  GLY B 171   N  THR B 168
SHEET    1 AA4 8 GLU C  35  VAL C  41  0
SHEET    2 AA4 8 VAL C  44  GLY C  52 -1  O  VAL C  44   N  VAL C  41
SHEET    3 AA4 8 THR C  82  PRO C  86 -1  O  VAL C  83   N  GLY C  51
SHEET    4 AA4 8 LEU C  56  VAL C  60  1  N  VAL C  57   O  THR C  82
SHEET    5 AA4 8 PHE C 123  HIS C 128  1  O  VAL C 126   N  VAL C  60
SHEET    6 AA4 8 ILE C 146  MET C 152  1  O  VAL C 150   N  ALA C 127
SHEET    7 AA4 8 THR C 261  GLY C 266  1  O  MET C 262   N  TYR C 151
SHEET    8 AA4 8 VAL C 287  LEU C 292  1  O  LEU C 292   N  ALA C 265
SHEET    1 AA5 8 GLU D  35  VAL D  41  0
SHEET    2 AA5 8 VAL D  44  GLY D  52 -1  O  LEU D  46   N  ARG D  39
SHEET    3 AA5 8 THR D  82  PRO D  86 -1  O  VAL D  83   N  GLY D  51
SHEET    4 AA5 8 LEU D  56  VAL D  60  1  N  VAL D  57   O  ILE D  84
SHEET    5 AA5 8 PHE D 123  HIS D 128  1  O  ASP D 124   N  MET D  58
SHEET    6 AA5 8 ILE D 146  MET D 152  1  O  VAL D 150   N  LEU D 125
SHEET    7 AA5 8 THR D 261  GLY D 266  1  O  MET D 262   N  TYR D 151
SHEET    8 AA5 8 VAL D 287  LEU D 292  1  O  LEU D 292   N  ALA D 265
SHEET    1 AA6 2 PHE D 167  THR D 168  0
SHEET    2 AA6 2 GLY D 171  GLU D 172 -1  O  GLY D 171   N  THR D 168
SSBOND   1 CYS A  295    CYS A  303                          1555   1555  2.00
SSBOND   2 CYS B  295    CYS B  303                          1555   1555  2.00
SSBOND   3 CYS C  295    CYS C  303                          1555   1555  2.01
SSBOND   4 CYS D  295    CYS D  303                          1555   1555  1.99
LINK         OD1 ASP A 129                 C2 B7F6 A 401     1555   1555  1.39
LINK         OD1 ASP C 129                 C2 B7F6 C 401     1555   1555  1.39
SITE     1 AC1 12 PHE A  63  ASP A 129  GLN A 153  ALA A 154
SITE     2 AC1 12 LEU A 174  HIS A 177  PHE A 178  PHE A 203
SITE     3 AC1 12 HIS A 207  TYR A 239  MET A 272  HIS A 297
SITE     1 AC2 17 PHE C  63  HIS C 128  ILE C 130  GLY C 131
SITE     2 AC2 17 ILE C 132  MET C 152  GLN C 153  ALA C 154
SITE     3 AC2 17 LEU C 174  HIS C 177  PHE C 178  PHE C 203
SITE     4 AC2 17 HIS C 207  TYR C 239  MET C 272  HIS C 297
SITE     5 AC2 17 HOH C 635
CRYST1  167.944   83.690   89.175  90.00 100.31  90.00 C 1 2 1      16
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.005954  0.000000  0.001083        0.00000
SCALE2      0.000000  0.011949  0.000000        0.00000
SCALE3      0.000000  0.000000  0.011398        0.00000
TER    2415      HIS A 321
TER    4788      HIS B 320
TER    7199      HIS C 321
TER    9581      HIS D 320
MASTER      446    0    2   64   36    0    8    610614    4   40   96
END